Search of human proteins with 30425563

Search of human proteins with 30425563

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
         (420 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                862   0.0  
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                352   3e-97
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]             305   5e-83
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         138   1e-32
gi|194440719 chondroadherin-like [Homo sapiens]                       136   3e-32
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         130   2e-30
gi|88702793 slit-like 2 [Homo sapiens]                                127   2e-29
gi|12007646 nyctalopin precursor [Homo sapiens]                       126   3e-29
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               124   2e-28
gi|225579152 insulin-like growth factor binding protein, acid la...   121   1e-27
gi|4826772 insulin-like growth factor binding protein, acid labi...   121   1e-27
gi|51317373 netrin-G1 ligand [Homo sapiens]                           121   1e-27
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           121   1e-27
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                   120   2e-27
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   119   4e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   119   4e-27
gi|5729718 trophoblast glycoprotein [Homo sapiens]                    118   9e-27
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]             117   1e-26
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]             117   1e-26
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]      117   2e-26
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   116   3e-26
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   116   3e-26
gi|198041768 synleurin [Homo sapiens]                                 113   4e-25
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   112   6e-25
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   112   6e-25
gi|153251229 chondroadherin precursor [Homo sapiens]                  108   9e-24
gi|157694513 leucine-rich repeat-containing G protein-coupled re...   108   1e-23
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...   107   3e-23
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   107   3e-23
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]        106   3e-23

>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  862 bits (2226), Expect = 0.0
 Identities = 420/420 (100%), Positives = 420/420 (100%)

Query: 1   MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPP 60
           MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPP
Sbjct: 1   MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPP 60

Query: 61  STQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           STQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR
Sbjct: 61  STQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
           SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN
Sbjct: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240
           LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240

Query: 241 SLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLR 300
           SLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLR
Sbjct: 241 SLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLR 300

Query: 301 ALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQ 360
           ALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQ
Sbjct: 301 ALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQ 360

Query: 361 GGDAPTEDDYWGGYGGEDQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCLLLLVPHHL 420
           GGDAPTEDDYWGGYGGEDQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCLLLLVPHHL
Sbjct: 361 GGDAPTEDDYWGGYGGEDQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCLLLLVPHHL 420


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score =  352 bits (904), Expect = 3e-97
 Identities = 176/300 (58%), Positives = 217/300 (72%), Gaps = 2/300 (0%)

Query: 17  LLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLR 76
           LLL+   LPL    CP  C CY +P TVSCQA+NF+++P  +P  ++R+FLQNN I  L+
Sbjct: 12  LLLVAAELPLGG-GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQ 70

Query: 77  PGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSL 136
           PG F   ++TLW++SNN++ I+P TF     LEELDLGDNR LR+L P+TFQGL +L +L
Sbjct: 71  PGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHAL 130

Query: 137 HLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTE 196
           +LY+C LS+LP  +F GL SLQYLYLQ+N + +LQDD+F DL NLSHLFLHGN+L  L  
Sbjct: 131 YLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGP 190

Query: 197 HVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFL 256
             FRGL +LDRLLLH N+LQ VH  AF  L RLT L+LFNNSL+ L GE LA L +LEFL
Sbjct: 191 GTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFL 250

Query: 257 RLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACP-PAAP 315
           RLN NPW C CRAR LW W QR R SSS V C +P  R G+DL+ LR  DF+ C  PA+P
Sbjct: 251 RLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASP 310


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score =  305 bits (781), Expect = 5e-83
 Identities = 175/358 (48%), Positives = 216/358 (60%), Gaps = 13/358 (3%)

Query: 18  LLMLLALPLAAPSCPMLCTCYSSPP-TVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLR 76
           +L L A  +AAP CP  C CY+ P  T SC      +VP+ +P ++QR+FL  N I  + 
Sbjct: 15  VLWLQAWQVAAP-CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVP 73

Query: 77  PGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQ 134
             +F +  NL  LWL SN L+ I    F  L  LE+LDL DN  LRS++P TF GL RL 
Sbjct: 74  AASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLH 133

Query: 135 SLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLL 194
           +LHL RC L  L   +FRGL +LQYLYLQ+N+L  L DD F DL NL+HLFLHGNR+  +
Sbjct: 134 TLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSV 193

Query: 195 TEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLE 254
            E  FRGL SLDRLLLH NR+  VH  AFR L RL  LYLF N+L++LP EALA L +L+
Sbjct: 194 PERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQ 253

Query: 255 FLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACPPA- 313
           +LRLN NPW CDCRARPLWAW Q+ R SSS+V C+ P    GRDL+ L   D Q C  A 
Sbjct: 254 YLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVAT 313

Query: 314 APTRPGSRARGNSSSNHLYGVAEAGAPPA--DPSTLYRDLPAEDSRGRQG----GDAP 365
            P  P     G ++     G+ +   P A    S L    PA      +G    GD+P
Sbjct: 314 GPYHP--IWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSP 369


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  138 bits (347), Expect = 1e-32
 Identities = 118/373 (31%), Positives = 152/373 (40%), Gaps = 60/373 (16%)

Query: 13  ASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLI 72
           A A L L+LL LPL A  CP  C CYS+  TV C A     VPL +PP TQ LFLQ+   
Sbjct: 5   APALLPLLLLLLPLRAAGCPAACRCYSA--TVECGALRLRVVPLGIPPGTQTLFLQD--- 59

Query: 73  RTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLER 132
                              NN++ + PG    L AL  L L  N  LR+LE   F+   R
Sbjct: 60  -------------------NNIARLEPGALAPLAALRRLYL-HNNSLRALEAGAFRAQPR 99

Query: 133 LQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLR 192
           L  L L   +L  L    F GL  L+ LYL  N L  L D  F  L  L  L L  N + 
Sbjct: 100 LLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIE 159

Query: 193 LLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPS 252
           LL +    GL SL  L L  N+L  + R A + L+ L +                     
Sbjct: 160 LLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQV--------------------- 198

Query: 253 LEFLRLNANPWACDCRARPLWAWFQ---RARVSSSD--VTCATPPERQGRDLRALREADF 307
              LRL  NPW CDC    L AW +   +  ++S D  + CA PP    + L  +  +  
Sbjct: 199 ---LRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSL 255

Query: 308 QACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTE 367
              PP+   +P      N   +       +G P   P   +R +P +   GR    A  E
Sbjct: 256 ICIPPSVHVQP-LELTANLGEDLRVACQASGYP--QPLVTWRKVP-QPREGRPRAQAQLE 311

Query: 368 DDY--WGGYGGED 378
                 GG+   D
Sbjct: 312 GGLLGLGGHSASD 324


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  136 bits (343), Expect = 3e-32
 Identities = 129/396 (32%), Positives = 162/396 (40%), Gaps = 66/396 (16%)

Query: 2   LPGLRRLLQAPASACLLLMLLALPL---AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSL 58
           + G R     P    LL++LL  P    AA  CP  C C +S   V+C+  N + VP ++
Sbjct: 1   MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAI 60

Query: 59  PPSTQRLFLQNNLIRTLRPGTFGS--------------------------NLLTLWLFSN 92
           P  TQRL LQ NL++ +    F                             LL L L SN
Sbjct: 61  PELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120

Query: 93  NLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFR 152
           +L  +       L +L  L+L  N  L  L P TF  L  L +L+L    L  LP   F+
Sbjct: 121 HLRELPQEALDGLGSLRRLELEGNA-LEELRPGTFGALGALATLNLAHNALVYLPAMAFQ 179

Query: 153 GLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVF---RGLGSLD--- 206
           GL+ +++L L  N+L  L  +  A L  L  L LH N L+ L   V    RGL  L+   
Sbjct: 180 GLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGH 239

Query: 207 ------------------RLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALA 248
                              LLL G  LQ +   AF    RL  L L  N L +LP   L 
Sbjct: 240 NPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP--PLQ 297

Query: 249 DLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQ 308
               L  LRL  NP  C C+ARPL  W  RARV  SD  C  P   +G  L ALR  D +
Sbjct: 298 GPGQLRRLRLQGNPLWCGCQARPLLEWLARARV-RSDGACQGPRRLRGEALDALRPWDLR 356

Query: 309 ACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADP 344
                    PG  A+          VA   APP  P
Sbjct: 357 C--------PGDAAQEEEELEE-RAVAGPRAPPRGP 383



 Score =  109 bits (272), Expect = 5e-24
 Identities = 100/337 (29%), Positives = 142/337 (42%), Gaps = 57/337 (16%)

Query: 27  AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NL 84
           A   CP  C C       SC+     +VP   P  TQ L L+ N   ++    F    +L
Sbjct: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451

Query: 85  LTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLS 144
           ++L L    ++ +  G    L  L  L L DN+ L  L     +G  RL  L+L R +  
Sbjct: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQ-LAGLSAAALEGAPRLGYLYLERNRFL 510

Query: 145 SLPGNIFRGLVSLQYLYLQENSL------------------------------------- 167
            +PG   R L SL  L+LQ+N++                                     
Sbjct: 511 QVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARE 570

Query: 168 ---LHLQDDLFAD--------LANLSHLFLHGNRLRLLTEHVFRGLG-SLDRLLLHGNRL 215
              LHL  +   +        L  L  L L GN LR L +  F+ +G SL  L L+ + L
Sbjct: 571 LEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGL 630

Query: 216 QGVHRAAFRGLSR-LTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWA 274
           + +   AF GL   L  L+L  N L +LP  AL  L  LE + L++NP+ CDC+  PL  
Sbjct: 631 EQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHR 688

Query: 275 WFQRARVSSSDVTCATPPERQGRDLRALREADFQACP 311
           W     +     TCATPP  +G+ ++A   A F+ CP
Sbjct: 689 WLTGLNLRVG-ATCATPPNARGQRVKA-AAAVFEDCP 723


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  130 bits (328), Expect = 2e-30
 Identities = 104/320 (32%), Positives = 150/320 (46%), Gaps = 32/320 (10%)

Query: 28  APSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NLL 85
           A SCP+ C+C +    V C   + + VP S+P +T+ L LQ N I+ +R  TF    +L 
Sbjct: 54  ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113

Query: 86  TLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSS 145
            L L  N +  I  G F  L +L  L+L DNR L ++    F+ L +L+ L L    + S
Sbjct: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR-LTTVPTQAFEYLSKLRELWLRNNPIES 172

Query: 146 LPGNIFRGLVSLQYLYLQE-NSLLHLQDDLFADLANLSHLFL------------------ 186
           +P   F  + SL+ L L E   L ++ +  F  L NL +L L                  
Sbjct: 173 IPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLE 232

Query: 187 ----HGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASL 242
                GNRL L+    F+GL SL +L L   ++  + R AF  L  L  L L +N+L SL
Sbjct: 233 ELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSL 292

Query: 243 PGEALADLPSLEFLRLNANPWACDCRARPLW-AWFQRARVSSSDVTCA---TPPERQGRD 298
           P +    L  LE + LN NPW C+C    LW +W+ +  V S+   CA    P   +GR 
Sbjct: 293 PHDLFTPLHRLERVHLNHNPWHCNCDV--LWLSWWLKETVPSNTTCCARCHAPAGLKGRY 350

Query: 299 LRALREADFQACPPAAPTRP 318
           +  L ++ F    P     P
Sbjct: 351 IGELDQSHFTCYAPVIVEPP 370


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score =  127 bits (318), Expect = 2e-29
 Identities = 124/384 (32%), Positives = 161/384 (41%), Gaps = 62/384 (16%)

Query: 18  LLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRP 77
           LL+LLAL      CP  C C S P TV C A   ++VP  +PP T  L++  N I  L  
Sbjct: 11  LLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDA 69

Query: 78  GTFG--------------------------SNLLTLWLFSNNLSTIYPGTFRHLQALEEL 111
           G+F                           +NL  L L +N L  I   TFR L+ LE L
Sbjct: 70  GSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERL 129

Query: 112 DLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQ 171
            LG NR +R ++P  F  L+RL  L L   +L +LP      L  L  L L  NSLL L+
Sbjct: 130 YLGKNR-IRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHNSLLALE 185

Query: 172 DDLFADLANLSHLFLHGNRLRLLTEHVF-----------------------RGLGSLDRL 208
             +  D AN+  L L G  L+ L E +F                       RGL  L RL
Sbjct: 186 PGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRL 244

Query: 209 LLHGN-RLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDC 267
            L GN R+  +      GL+ L  L + N SL +LPG+     P L  L    NP+ C C
Sbjct: 245 RLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVC 304

Query: 268 RARPLWAWFQRARV---SSSDVTCATPPERQGRDLRALREADFQACPPAAPTR--PGSRA 322
                  W + + V   S  +  C  PP+  GR L  L  ADF  CP    T   P +R 
Sbjct: 305 PLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF-GCPATTTTATVPTTRP 363

Query: 323 RGNSSSNHLYGVAEAGAPPADPST 346
                +     +A     P +P+T
Sbjct: 364 VVREPTALSSSLAPTWLSPTEPAT 387


>gi|12007646 nyctalopin precursor [Homo sapiens]
          Length = 481

 Score =  126 bits (317), Expect = 3e-29
 Identities = 120/369 (32%), Positives = 146/369 (39%), Gaps = 88/369 (23%)

Query: 17  LLLMLLALPLAAPS----------CPMLCTCYSSPP--TVSCQANNFSSVPLSLPPSTQR 64
           L+L+L A+ L  PS          CP  C C +     +V C       VP  LP     
Sbjct: 7   LVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVS 66

Query: 65  LFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
           + L  N +R L    FG+  +L  L L  NNLS I PG F+ L  L EL L  N  LR L
Sbjct: 67  IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126

Query: 123 EPDTFQGLERLQSLHLYRCQLSSLP----------------GNIFR-------------- 152
              TF  L RL+ L L  C+L S+P                 N+FR              
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTH 186

Query: 153 -----------------GLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLT 195
                            GL  L+ L LQ N +  +    F D   L HL L+ N L  L 
Sbjct: 187 AHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELP 246

Query: 196 EHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEF 255
              FRGL  L  L L GN L  V RA F  L+ L +LYL  NS+A +   A  +L  L  
Sbjct: 247 ADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLA 306

Query: 256 LRLNA------------------------NPWACDCRARPLWAWFQ-RARVSSSDVTCAT 290
           L LN                         NPW CDCR   L  W +   RV  +DV CA+
Sbjct: 307 LHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRV--TDVPCAS 364

Query: 291 PPERQGRDL 299
           P    G DL
Sbjct: 365 PGSVAGLDL 373



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 42/120 (35%), Positives = 47/120 (39%), Gaps = 26/120 (21%)

Query: 186 LHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNS-LASLPG 244
           L  N LR L E  F  L SL RL L  N L  +   AF+GL RL  L L +N  L  L  
Sbjct: 69  LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHA 128

Query: 245 EALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALRE 304
              A L  L  L L A      CR   +                   PER   +L ALRE
Sbjct: 129 RTFAALSRLRRLDLAA------CRLFSV-------------------PERLLAELPALRE 163


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  124 bits (310), Expect = 2e-28
 Identities = 107/308 (34%), Positives = 134/308 (43%), Gaps = 10/308 (3%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           S  +L L  N +  L    F    NLL L L SN +  +    F  L  L  L+L  N  
Sbjct: 156 SLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANEL 215

Query: 119 LRSLE-PDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
             SL    TF  L  L SL L    L  L   IF+ L  L  L L+ N L HL  + F  
Sbjct: 216 QPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWG 275

Query: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
           L  L  L L GNRL  L   +   L SL+ L L GN L  +H A F  L RL  L L NN
Sbjct: 276 LEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNN 335

Query: 238 SLASLPGEALADLPSLEFLRLNANPWACDCRARPL--WA--WFQRARVSSSDVTCATPPE 293
           +L++L G+  A  P+L  L L+ N W CDCR R L  W   W  + R+ +  V C  PP 
Sbjct: 336 ALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPA 395

Query: 294 RQGRDLRALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPA 353
            +G+ L  L +   Q    A P+   S               E   PPA    L  +LP 
Sbjct: 396 LRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAG---LAEELPP 452

Query: 354 EDSRGRQG 361
           +    +QG
Sbjct: 453 QPQLQQQG 460



 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 96/285 (33%), Positives = 121/285 (42%), Gaps = 54/285 (18%)

Query: 9   LQAPASACLLLML---LALP-LAAPSCPMLCTCYSSPPTVSCQANNFSSVPL--SLPPST 62
           ++A  +  LLL++   LALP LA P CP  C C   P  + C       VP   SLP   
Sbjct: 1   MEAARALRLLLVVCGCLALPPLAEPVCPERCDC-QHPQHLLCTNRGLRVVPKTSSLPSP- 58

Query: 63  QRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
                               ++LT  L  N ++ I    F  L  L  LDL  N+ +RSL
Sbjct: 59  -------------------HDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQ-IRSL 98

Query: 123 EPDTFQGLERLQSLHLYRCQLSSL-PGNI-----------------------FRGLVSLQ 158
            P TF+ L RL+ L+L    L +L PG +                       F GL SL 
Sbjct: 99  HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158

Query: 159 YLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV 218
            L L  N+L  L D +FA L NL +L L  NR+R L ++ F  LG L  L L  N LQ  
Sbjct: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218

Query: 219 --HRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
             H A F  L  L+ L L  N+L  L       LP L  L L  N
Sbjct: 219 LRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGN 263


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score =  121 bits (304), Expect = 1e-27
 Identities = 87/237 (36%), Positives = 114/237 (48%), Gaps = 27/237 (11%)

Query: 29  PSCPMLCTCY----SSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNL 84
           P+CP  C C     +   +V C + N + +P  +P  TQ                     
Sbjct: 77  PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQ--------------------- 115

Query: 85  LTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLS 144
             LWL  NNLS++ P  F++L +L  L+L   + L SLEP    GLE L  LHL R QL 
Sbjct: 116 -ALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQ-LGSLEPQALLGLENLCHLHLERNQLR 173

Query: 145 SLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGS 204
           SL    F    +L  L L  N L  L+D LF  L +L  L L  N L +L +  FRGLGS
Sbjct: 174 SLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 233

Query: 205 LDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
           L  L+L GNRL  +  A F GL+ L  L L  N+L ++       LP L+ L L+ N
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 290



 Score =  113 bits (283), Expect = 3e-25
 Identities = 96/290 (33%), Positives = 129/290 (44%), Gaps = 43/290 (14%)

Query: 63  QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           + L L +N IR L   +F     L  L L  N L  +  G F  L  +  ++L  N  LR
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 413

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
           +L    F+GL +L SLHL    L  +  + F GL  L+ L+L++N L+ +++     LA 
Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240
           L  L L  N+L  L   +F+GLG L+ LLL  NRL  +   A   L R   L + +N L 
Sbjct: 474 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 533

Query: 241 SLPGEALADL--------------------PSLEFLRLNANPWACDCRARPLWAW----- 275
           +LP   LA L                    P LE L L  NPW C C  + L  +     
Sbjct: 534 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNP 593

Query: 276 -----FQRARVSSSD----------VTCATPPERQGRDLRALREADFQAC 310
                F +A     D          +TCA+PPE  G DLR L EA F  C
Sbjct: 594 SAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643



 Score =  101 bits (251), Expect = 1e-21
 Identities = 74/204 (36%), Positives = 99/204 (48%), Gaps = 3/204 (1%)

Query: 60  PSTQRLFLQNNLIRTLRPGTFGSNLLTLWL--FSNNLSTIYPGTFRHLQALEELDLGDNR 117
           P  Q+L+L  NLI  + PG F       WL    N ++ +   TF  L  L  L L  N 
Sbjct: 280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 339

Query: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
            + SL P TF+ L  L+ L L   ++  L    F GL  L+ L L  N L  ++   F  
Sbjct: 340 -IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398

Query: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
           L N++ + L GN LR L E VFRGLG L  L L G+ L  +    F GLS L  L+L +N
Sbjct: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458

Query: 238 SLASLPGEALADLPSLEFLRLNAN 261
            L  +  ++L  L  L  L L +N
Sbjct: 459 GLVGIEEQSLWGLAELLELDLTSN 482



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 74/213 (34%), Positives = 104/213 (48%), Gaps = 6/213 (2%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           S + L L  N +  L+P  F   + L  L L  N L  I    F  L  L++L L D   
Sbjct: 233 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYL-DRNL 291

Query: 119 LRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADL 178
           + ++ P  F GL+ L+ L L   +++ L  + F GL+ L+ L L  N++  L+   F DL
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351

Query: 179 ANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNS 238
             L  L L  NR+R L E  F GLG L+ L L  N+LQ V   AF GL+ + ++ L  N 
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411

Query: 239 LASLPGEALADLPSLEFLRLNANPWACDCRARP 271
           L +LP +    L  L  L L     +C  R RP
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEG---SCLGRIRP 441



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 3/122 (2%)

Query: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
           L+ LP  +  G    Q L+L  N+L  +    F +L++L  L L G +L  L      GL
Sbjct: 103 LTRLPDGVPGGT---QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL 159

Query: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANP 262
            +L  L L  N+L+ +    F     L  L L NN L+ L       L SL  L L  N 
Sbjct: 160 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 219

Query: 263 WA 264
            A
Sbjct: 220 LA 221


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score =  121 bits (304), Expect = 1e-27
 Identities = 87/237 (36%), Positives = 114/237 (48%), Gaps = 27/237 (11%)

Query: 29  PSCPMLCTCY----SSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNL 84
           P+CP  C C     +   +V C + N + +P  +P  TQ                     
Sbjct: 39  PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQ--------------------- 77

Query: 85  LTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLS 144
             LWL  NNLS++ P  F++L +L  L+L   + L SLEP    GLE L  LHL R QL 
Sbjct: 78  -ALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQ-LGSLEPQALLGLENLCHLHLERNQLR 135

Query: 145 SLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGS 204
           SL    F    +L  L L  N L  L+D LF  L +L  L L  N L +L +  FRGLGS
Sbjct: 136 SLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 195

Query: 205 LDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
           L  L+L GNRL  +  A F GL+ L  L L  N+L ++       LP L+ L L+ N
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 252



 Score =  113 bits (283), Expect = 3e-25
 Identities = 96/290 (33%), Positives = 129/290 (44%), Gaps = 43/290 (14%)

Query: 63  QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           + L L +N IR L   +F     L  L L  N L  +  G F  L  +  ++L  N  LR
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 375

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
           +L    F+GL +L SLHL    L  +  + F GL  L+ L+L++N L+ +++     LA 
Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240
           L  L L  N+L  L   +F+GLG L+ LLL  NRL  +   A   L R   L + +N L 
Sbjct: 436 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 495

Query: 241 SLPGEALADL--------------------PSLEFLRLNANPWACDCRARPLWAW----- 275
           +LP   LA L                    P LE L L  NPW C C  + L  +     
Sbjct: 496 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNP 555

Query: 276 -----FQRARVSSSD----------VTCATPPERQGRDLRALREADFQAC 310
                F +A     D          +TCA+PPE  G DLR L EA F  C
Sbjct: 556 SAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605



 Score =  101 bits (251), Expect = 1e-21
 Identities = 74/204 (36%), Positives = 99/204 (48%), Gaps = 3/204 (1%)

Query: 60  PSTQRLFLQNNLIRTLRPGTFGSNLLTLWL--FSNNLSTIYPGTFRHLQALEELDLGDNR 117
           P  Q+L+L  NLI  + PG F       WL    N ++ +   TF  L  L  L L  N 
Sbjct: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 301

Query: 118 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD 177
            + SL P TF+ L  L+ L L   ++  L    F GL  L+ L L  N L  ++   F  
Sbjct: 302 -IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360

Query: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
           L N++ + L GN LR L E VFRGLG L  L L G+ L  +    F GLS L  L+L +N
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420

Query: 238 SLASLPGEALADLPSLEFLRLNAN 261
            L  +  ++L  L  L  L L +N
Sbjct: 421 GLVGIEEQSLWGLAELLELDLTSN 444



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 74/213 (34%), Positives = 104/213 (48%), Gaps = 6/213 (2%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           S + L L  N +  L+P  F   + L  L L  N L  I    F  L  L++L L D   
Sbjct: 195 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYL-DRNL 253

Query: 119 LRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADL 178
           + ++ P  F GL+ L+ L L   +++ L  + F GL+ L+ L L  N++  L+   F DL
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313

Query: 179 ANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNS 238
             L  L L  NR+R L E  F GLG L+ L L  N+LQ V   AF GL+ + ++ L  N 
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373

Query: 239 LASLPGEALADLPSLEFLRLNANPWACDCRARP 271
           L +LP +    L  L  L L     +C  R RP
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEG---SCLGRIRP 403



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 3/122 (2%)

Query: 143 LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
           L+ LP  +  G    Q L+L  N+L  +    F +L++L  L L G +L  L      GL
Sbjct: 65  LTRLPDGVPGGT---QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGL 121

Query: 203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANP 262
            +L  L L  N+L+ +    F     L  L L NN L+ L       L SL  L L  N 
Sbjct: 122 ENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS 181

Query: 263 WA 264
            A
Sbjct: 182 LA 183


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  121 bits (304), Expect = 1e-27
 Identities = 106/340 (31%), Positives = 154/340 (45%), Gaps = 43/340 (12%)

Query: 17  LLLMLLALPLA-------APSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQN 69
           LL++LLAL L        A +CP +C+C +    V C   N   VP  +  +T+ L L  
Sbjct: 26  LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHE 85

Query: 70  NLI------------------------RTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFR 103
           N I                        RT+  G F   +NL TL LF N L+TI  G F 
Sbjct: 86  NQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFV 145

Query: 104 HLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQ-LSSLPGNIFRGLVSLQYLYL 162
           +L  L+EL L +N  + S+    F  +  L+ L L   + LS +    F GL +L+YL L
Sbjct: 146 YLSKLKELWLRNNP-IESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNL 204

Query: 163 QENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAA 222
              +L  + +     L  L  L L GN L  +    F+GL  L +L +  +++Q + R A
Sbjct: 205 AMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNA 262

Query: 223 FRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLW-AWFQRARV 281
           F  L  L  + L +N+L  LP +    L  LE + L+ NPW C+C    LW +W+ +   
Sbjct: 263 FDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDI--LWLSWWIKDMA 320

Query: 282 SSSDVTCA---TPPERQGRDLRALREADFQACPPAAPTRP 318
            S+   CA   TPP  +GR +  L +  F    P     P
Sbjct: 321 PSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  121 bits (303), Expect = 1e-27
 Identities = 100/326 (30%), Positives = 147/326 (45%), Gaps = 33/326 (10%)

Query: 17  LLLMLLALPLAAP-SCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTL 75
           L   + A   A P +CP +C+C +    V C     S VP  +P +T+ L L  N I+ +
Sbjct: 31  LCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90

Query: 76  RPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERL 133
           +  TF    +L  L L  N++  I  G F  L +L  L+L DN  L  +    F+ L +L
Sbjct: 91  QADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDN-WLTVIPSGAFEYLSKL 149

Query: 134 QSLHLYRCQLSSLPGNIFRGLVSLQYLYLQE-NSLLHLQDDLFADLANLSHLFL------ 186
           + L L    + S+P   F  + SL  L L E   L ++ +  F  L NL +L L      
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIK 209

Query: 187 ----------------HGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLT 230
                            GN    +    F GL SL +L +  +++  + R AF GL+ L 
Sbjct: 210 DMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLV 269

Query: 231 ILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLW-AWFQRARVSSSDVTCA 289
            L L +N+L+SLP +    L  L  L L+ NPW CDC    LW AW+ R  + ++   C 
Sbjct: 270 ELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDI--LWLAWWLREYIPTNSTCCG 327

Query: 290 ---TPPERQGRDLRALREADFQACPP 312
               P   +GR L  + +A FQ   P
Sbjct: 328 RCHAPMHMRGRYLVEVDQASFQCSAP 353


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score =  120 bits (302), Expect = 2e-27
 Identities = 101/278 (36%), Positives = 132/278 (47%), Gaps = 11/278 (3%)

Query: 57  SLPPSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLG 114
           SL   T+  F +N+ IR++ PG F    NL +L L  N+L+ +    F H   L  L L 
Sbjct: 216 SLGALTELQFHRNH-IRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLF 274

Query: 115 DNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLH-LQDD 173
           +N  L  L    F  +  LQ L L R QL +LP   FR L  L+YL +  +  L  L   
Sbjct: 275 ENP-LAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQG 333

Query: 174 LFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILY 233
            F  L  L  L LH N L  L + + RGLG L ++ L  NRL+ + RA FR LS L  + 
Sbjct: 334 AFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQ 393

Query: 234 LFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQR--ARVSSSD-VTCAT 290
           L +N L +LPG+    LP L  + L  N W CDC   P   W ++    V   +   CA 
Sbjct: 394 LDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAG 453

Query: 291 PPERQGRDLRALREADFQACPPAAPTRPGSRARGNSSS 328
           P    G  L AL   D + CP   P  P  R   +SSS
Sbjct: 454 PGAHAGLPLWALPGGDAE-CP--GPRGPPPRPAADSSS 488



 Score =  102 bits (254), Expect = 6e-22
 Identities = 76/220 (34%), Positives = 106/220 (48%), Gaps = 8/220 (3%)

Query: 47  QANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRH 104
           Q+ +FS + +      QRL + ++ I  + PGTF     L TL L  N ++ +       
Sbjct: 66  QSQSFSGMTV-----LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120

Query: 105 LQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQE 164
           +  LE+L L D+  LR ++ + FQ L  LQ L L + QL  LP ++F  L +L+ L L  
Sbjct: 121 MVLLEQLFL-DHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSG 179

Query: 165 NSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFR 224
           N+L HL   L    A L  L LH NRL  L   +   LG+L  L  H N ++ +   AF 
Sbjct: 180 NNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFD 239

Query: 225 GLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWA 264
            L  L+ L L  N LA LP        +L  L L  NP A
Sbjct: 240 RLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLA 279



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 69/202 (34%), Positives = 91/202 (45%), Gaps = 4/202 (1%)

Query: 63  QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           Q L L  N +  L    F +  NL  L L  NNL+ +  G       LE L L  NR L 
Sbjct: 149 QELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR-LV 207

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
           SL+      L  L  L  +R  + S+    F  L +L  L L  N L  L   LF    N
Sbjct: 208 SLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHN 267

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTIL-YLFNNSL 239
           L+ L L  N L  L   +F  +G L  L L+  +L+ +  AAFR LSRL  L    +  L
Sbjct: 268 LTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRL 327

Query: 240 ASLPGEALADLPSLEFLRLNAN 261
           ++LP  A   L  L+ L L++N
Sbjct: 328 SALPQGAFQGLGELQVLALHSN 349



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 45/140 (32%), Positives = 70/140 (50%)

Query: 122 LEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANL 181
           L+  +F G+  LQ L +    +S++    F  L+ L+ L L  N + HL   L   +  L
Sbjct: 65  LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124

Query: 182 SHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLAS 241
             LFL  N LR + +++F+ L +L  L L+ N+L  +  + F  L  L +L L  N+L  
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184

Query: 242 LPGEALADLPSLEFLRLNAN 261
           LP   L     LE L L++N
Sbjct: 185 LPKGLLGAQAKLERLLLHSN 204



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 27/82 (32%), Positives = 39/82 (47%)

Query: 180 NLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
           NL+H+ L G    +L    F G+  L RL++  + +  V    F  L +L  L L  N +
Sbjct: 51  NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110

Query: 240 ASLPGEALADLPSLEFLRLNAN 261
             LPG  L  +  LE L L+ N
Sbjct: 111 THLPGALLDKMVLLEQLFLDHN 132


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  119 bits (299), Expect = 4e-27
 Identities = 87/242 (35%), Positives = 116/242 (47%), Gaps = 6/242 (2%)

Query: 63  QRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           Q L LQ N I  L PG F +N  L  L+L +N++S + P  F  L  L  L L  N  L+
Sbjct: 230 QELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS-LK 288

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
            L    F  +  L+ L LY   +SSLP N+F  L  LQ L L  N +  +    F  L  
Sbjct: 289 ELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTE 348

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240
           L  L LH N L+ L  +VFR L +L  + L  NRL+ +    F  ++ L  + L NN L 
Sbjct: 349 LRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 408

Query: 241 SLPGEALADLPSLEFLRLNANPWACDCRARPL--WAWFQRARVSSSDV-TCATPPERQGR 297
           +LP      L  L  LRL  NPW CD    PL  W    + R+ +  V  C +P   +G+
Sbjct: 409 NLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 468

Query: 298 DL 299
            L
Sbjct: 469 SL 470



 Score =  116 bits (290), Expect = 4e-26
 Identities = 80/223 (35%), Positives = 115/223 (51%), Gaps = 6/223 (2%)

Query: 44  VSCQANNFSSVPLSL---PPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIY 98
           +S   N    +P+ L     S + L L +N +  ++P  F   SNL  L L  N+L  I 
Sbjct: 112 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171

Query: 99  PGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQ 158
            G F HL  L +L+LG N  L  + P  FQ L  LQ L LY  +L+ +P   F GLV+LQ
Sbjct: 172 DGAFDHLVGLTKLNLGKNS-LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQ 230

Query: 159 YLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV 218
            L LQ+N +  L   LF +  NL  L+L  N +  L   +F  L  L+RL L GN L+ +
Sbjct: 231 ELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL 290

Query: 219 HRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
               F  +  L  L+L++N ++SLP    ++L  L+ L L+ N
Sbjct: 291 SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333



 Score =  100 bits (250), Expect = 2e-21
 Identities = 78/238 (32%), Positives = 103/238 (43%), Gaps = 28/238 (11%)

Query: 26  LAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SN 83
           LA   CP  CTC S    V C      +VP  LP +   L + N  I  L    F   S 
Sbjct: 26  LAYHGCPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISA 84

Query: 84  LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQL 143
           L+ L +  N LS I PG FR+L +L  L L +N+                         L
Sbjct: 85  LIALRIEKNELSRITPGAFRNLGSLRYLSLANNK-------------------------L 119

Query: 144 SSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLG 203
             LP  +F+GL SL+ L L  N LL +Q   F+  +NL  L LHGN L  + +  F  L 
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179

Query: 204 SLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
            L +L L  N L  +    F+ L  L +L L+ N L  +P      L +L+ L L  N
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 237


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  119 bits (299), Expect = 4e-27
 Identities = 87/242 (35%), Positives = 116/242 (47%), Gaps = 6/242 (2%)

Query: 63  QRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
           Q L LQ N I  L PG F +N  L  L+L +N++S + P  F  L  L  L L  N  L+
Sbjct: 224 QELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS-LK 282

Query: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
            L    F  +  L+ L LY   +SSLP N+F  L  LQ L L  N +  +    F  L  
Sbjct: 283 ELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTE 342

Query: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLA 240
           L  L LH N L+ L  +VFR L +L  + L  NRL+ +    F  ++ L  + L NN L 
Sbjct: 343 LRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLE 402

Query: 241 SLPGEALADLPSLEFLRLNANPWACDCRARPL--WAWFQRARVSSSDV-TCATPPERQGR 297
           +LP      L  L  LRL  NPW CD    PL  W    + R+ +  V  C +P   +G+
Sbjct: 403 NLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 462

Query: 298 DL 299
            L
Sbjct: 463 SL 464



 Score =  116 bits (290), Expect = 4e-26
 Identities = 80/223 (35%), Positives = 115/223 (51%), Gaps = 6/223 (2%)

Query: 44  VSCQANNFSSVPLSL---PPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIY 98
           +S   N    +P+ L     S + L L +N +  ++P  F   SNL  L L  N+L  I 
Sbjct: 106 LSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165

Query: 99  PGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQ 158
            G F HL  L +L+LG N  L  + P  FQ L  LQ L LY  +L+ +P   F GLV+LQ
Sbjct: 166 DGAFDHLVGLTKLNLGKNS-LTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQ 224

Query: 159 YLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV 218
            L LQ+N +  L   LF +  NL  L+L  N +  L   +F  L  L+RL L GN L+ +
Sbjct: 225 ELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKEL 284

Query: 219 HRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
               F  +  L  L+L++N ++SLP    ++L  L+ L L+ N
Sbjct: 285 SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327



 Score =  100 bits (250), Expect = 2e-21
 Identities = 78/238 (32%), Positives = 103/238 (43%), Gaps = 28/238 (11%)

Query: 26  LAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SN 83
           LA   CP  CTC S    V C      +VP  LP +   L + N  I  L    F   S 
Sbjct: 20  LAYHGCPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISA 78

Query: 84  LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQL 143
           L+ L +  N LS I PG FR+L +L  L L +N+                         L
Sbjct: 79  LIALRIEKNELSRITPGAFRNLGSLRYLSLANNK-------------------------L 113

Query: 144 SSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLG 203
             LP  +F+GL SL+ L L  N LL +Q   F+  +NL  L LHGN L  + +  F  L 
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173

Query: 204 SLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
            L +L L  N L  +    F+ L  L +L L+ N L  +P      L +L+ L L  N
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 231


>gi|5729718 trophoblast glycoprotein [Homo sapiens]
          Length = 420

 Score =  118 bits (296), Expect = 9e-27
 Identities = 102/320 (31%), Positives = 128/320 (40%), Gaps = 51/320 (15%)

Query: 23  ALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG- 81
           A P     CP LC C  +  TV C   N + VP  LP   + LFL  N +  L  G F  
Sbjct: 54  AQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFAR 113

Query: 82  ----SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQG-------- 129
               + L  L L  + L  +  G F HL +L +LDL  N  L  L P  F G        
Sbjct: 114 RPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHN-PLADLSPFAFSGSNASVSAP 172

Query: 130 --LERLQSLHLY----RCQLSSLPGNIF------RGLVSLQYLYLQENSLLHLQDDLFAD 177
             L  L   H+       Q  S  G +       R L  L+ L L  N  L+L  D+ A 
Sbjct: 173 SPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQ 232

Query: 178 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN 237
           L +L HL L  N L  LT   FR L  L+ L L  N L+ +H                N 
Sbjct: 233 LPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLH----------------NG 276

Query: 238 SLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARV--SSSDVTCATPPERQ 295
           +LA L G     LP +    L+ NPW CDC    +  W +   V      +TCA P + +
Sbjct: 277 TLAELQG-----LPHIRVF-LDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMR 330

Query: 296 GRDLRALREADFQACPPAAP 315
            R L  L  AD   C P  P
Sbjct: 331 NRVLLELNSADLD-CDPILP 349


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  117 bits (294), Expect = 1e-26
 Identities = 95/275 (34%), Positives = 125/275 (45%), Gaps = 23/275 (8%)

Query: 7   RLLQAPASACLLLMLLALPLAAP------SCPMLCTC-----------YSSPPTVSCQAN 49
           RLL AP    LL  +     A P       CP  C C           Y    TV C   
Sbjct: 2   RLLVAPL---LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDL 58

Query: 50  NFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQA 107
             ++VP +LP  TQ L LQ+N I  +     G  +NL  L L  N+ S      F  L  
Sbjct: 59  FLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQ 118

Query: 108 LEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSL 167
           L  L L +N+ L  LE  +F GL  LQ L+L   QL  +    F GL +L  L+L  N L
Sbjct: 119 LLSLHLEENQ-LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177

Query: 168 LHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLS 227
             +    F  L NL  L + GN++  + +  FR L +L  L+L G  L+ +   A  GL 
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQ 237

Query: 228 RLTILYLFNNSLASLPGEALADLPSLEFLRLNANP 262
            L  L  ++N LA +P  AL  +P L+FL LN NP
Sbjct: 238 SLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 93/309 (30%), Positives = 138/309 (44%), Gaps = 33/309 (10%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR- 117
           S Q L+L +N +  + P  F   SNLL L L SN L  I    F  L  LE L +G N+ 
Sbjct: 142 SLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKV 201

Query: 118 ----------------------HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLV 155
                                 +LR +     +GL+ L+SL  Y  QL+ +P      + 
Sbjct: 202 DAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVP 261

Query: 156 SLQYLYLQENSLLHLQDDLFADLANLSHLFLHG-NRLRLLTEHVFRGLGSLDRLLLHGN- 213
            L++L L +N L  +    FA++ +L  L L+    L  + +     L  L +L +  N 
Sbjct: 262 GLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP 321

Query: 214 RLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLW 273
           RL  +H  AF  L ++  L L NN+L++L  + +  LP+L+ + L+ NP  CDC  R   
Sbjct: 322 RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN 381

Query: 274 AWFQRAR-VSSSDVTCATPPERQGRDLRAL--READFQACPPAAP-TRPGSR--ARGNSS 327
           A   R R +      CA PP+ Q   +R +  RE      P  +P + P S   A G S 
Sbjct: 382 ATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESM 441

Query: 328 SNHLYGVAE 336
             H   +AE
Sbjct: 442 VLHCRALAE 450


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score =  117 bits (294), Expect = 1e-26
 Identities = 95/275 (34%), Positives = 125/275 (45%), Gaps = 23/275 (8%)

Query: 7   RLLQAPASACLLLMLLALPLAAP------SCPMLCTC-----------YSSPPTVSCQAN 49
           RLL AP    LL  +     A P       CP  C C           Y    TV C   
Sbjct: 2   RLLVAPL---LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDL 58

Query: 50  NFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQA 107
             ++VP +LP  TQ L LQ+N I  +     G  +NL  L L  N+ S      F  L  
Sbjct: 59  FLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQ 118

Query: 108 LEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSL 167
           L  L L +N+ L  LE  +F GL  LQ L+L   QL  +    F GL +L  L+L  N L
Sbjct: 119 LLSLHLEENQ-LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLL 177

Query: 168 LHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLS 227
             +    F  L NL  L + GN++  + +  FR L +L  L+L G  L+ +   A  GL 
Sbjct: 178 RAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQ 237

Query: 228 RLTILYLFNNSLASLPGEALADLPSLEFLRLNANP 262
            L  L  ++N LA +P  AL  +P L+FL LN NP
Sbjct: 238 SLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNP 272



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 93/309 (30%), Positives = 138/309 (44%), Gaps = 33/309 (10%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR- 117
           S Q L+L +N +  + P  F   SNLL L L SN L  I    F  L  LE L +G N+ 
Sbjct: 142 SLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKV 201

Query: 118 ----------------------HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLV 155
                                 +LR +     +GL+ L+SL  Y  QL+ +P      + 
Sbjct: 202 DAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVP 261

Query: 156 SLQYLYLQENSLLHLQDDLFADLANLSHLFLHG-NRLRLLTEHVFRGLGSLDRLLLHGN- 213
            L++L L +N L  +    FA++ +L  L L+    L  + +     L  L +L +  N 
Sbjct: 262 GLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNP 321

Query: 214 RLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLW 273
           RL  +H  AF  L ++  L L NN+L++L  + +  LP+L+ + L+ NP  CDC  R   
Sbjct: 322 RLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWAN 381

Query: 274 AWFQRAR-VSSSDVTCATPPERQGRDLRAL--READFQACPPAAP-TRPGSR--ARGNSS 327
           A   R R +      CA PP+ Q   +R +  RE      P  +P + P S   A G S 
Sbjct: 382 ATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESM 441

Query: 328 SNHLYGVAE 336
             H   +AE
Sbjct: 442 VLHCRALAE 450


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score =  117 bits (293), Expect = 2e-26
 Identities = 94/321 (29%), Positives = 134/321 (41%), Gaps = 72/321 (22%)

Query: 16  CLLLMLLALPLAAP----SCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNL 71
           CLL+    + L A     +CP  C CY  P  V C     +S+P S+PP+          
Sbjct: 10  CLLVSFAVICLVATPGGKACPRRCACYM-PTEVHCTFRYLTSIPDSIPPN---------- 58

Query: 72  IRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLE 131
                                               +E ++LG N  +R +E D F GL 
Sbjct: 59  ------------------------------------VERINLGYNSLVRLMETD-FSGLT 81

Query: 132 RLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRL 191
           +L+ L L+   + ++P   F  L +LQ L +  N +  LQ D F  L +L+ L +  N +
Sbjct: 82  KLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNI 141

Query: 192 RLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTI--------LYLFNNSLASLP 243
             +   VF GL  L  + L GN+L  +H   F  LS L I        LYL +N L SLP
Sbjct: 142 EFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLP 201

Query: 244 GEALADLPSLEFLRLNANPWACDCRARPLWAWFQ---------RARVSSSD---VTCATP 291
            E ++ +P L+ L L+ NPW CDC  + L  W Q         + R  SS      C  P
Sbjct: 202 QEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPSSAQQCPLCMNP 261

Query: 292 PERQGRDLRALREADFQACPP 312
              +G+ L  +  A FQ   P
Sbjct: 262 RTSKGKPLAMVSAAAFQCAKP 282


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  116 bits (291), Expect = 3e-26
 Identities = 101/344 (29%), Positives = 144/344 (41%), Gaps = 55/344 (15%)

Query: 9   LQAPASACLLLM---LLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRL 65
           L AP  A +  M   L  LP    +CP  C C        C +  F SVP +    +  L
Sbjct: 9   LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKL--LFYCDSQGFHSVPNATDKGSLGL 66

Query: 66  FLQNNLIRTLRPGTFGSNLLTLWLF--SNNLSTIYPGTFRHLQALEELDLGDNR------ 117
            L++N I  L    F S     WL    N +ST+    F+ L  L+EL L  N+      
Sbjct: 67  SLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPN 126

Query: 118 -----------------HLRSLEPDTFQGLERLQSLHL-------------YRCQ----- 142
                             L SL P+ F GL +LQ+LHL             + C+     
Sbjct: 127 TTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFL 186

Query: 143 ------LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTE 196
                 L SL  N F GL+ L+ L+L+ N L  +    F  L++L  LFL  N++  LT 
Sbjct: 187 DLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTC 246

Query: 197 HVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFL 256
            +    G+L++L L GN ++ +    F  +  L IL + NN L SL  + L  L SL  +
Sbjct: 247 GMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTV 306

Query: 257 RLNANPWACDCRARPLWAWFQRARVS-SSDVTCATPPERQGRDL 299
            L+ N W C  R   L +W    +      + C +P   QG D+
Sbjct: 307 GLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDI 350


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  116 bits (291), Expect = 3e-26
 Identities = 91/255 (35%), Positives = 118/255 (46%), Gaps = 6/255 (2%)

Query: 61  STQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           S Q L L NN +  L  G FG   +L  L+L SNN+S + P  F  L  LE L L  N  
Sbjct: 194 SLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA- 252

Query: 119 LRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADL 178
           +  L    F  L  L  L L    L  LP  +F     L  L L  N L  + +  FA L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312

Query: 179 ANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNS 238
           +NL  L L  N +  L   +FR L  L +L L  N L  +H A F+ LS+L +L L  N 
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372

Query: 239 LASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQR--ARVSSSDVTCATPPERQG 296
           L +LP        +L  L L+ NPW CDC    L+ W Q+   R+ +    CA P   +G
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKG 432

Query: 297 RDLRALREADFQACP 311
           + + AL E     CP
Sbjct: 433 QVVPALNEKQL-VCP 446



 Score =  112 bits (279), Expect = 8e-25
 Identities = 91/275 (33%), Positives = 120/275 (43%), Gaps = 27/275 (9%)

Query: 12  PASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNL 71
           P +  L   LL L   A  CPM C C+     V C     ++VPL +PP T+ +      
Sbjct: 3   PGAWLLWTSLLLLARPAQPCPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVETS 60

Query: 72  IRTLRPGTFGSNL-LTLWLFSNN-LSTIYPGTFRHLQALEELDLGDNRHLR--------- 120
             TL    FGSN  LT  +F N  L    P  F  L  LE+L++  +  L          
Sbjct: 61  FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120

Query: 121 --------------SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENS 166
                         +L    FQ L  L+SLHL   QL +LP  +F+ L  L+ L L +N 
Sbjct: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180

Query: 167 LLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGL 226
           L  L ++LF  L +L  L L  N L  L + VF  LGSL  L L  N +  +    F  L
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240

Query: 227 SRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
             L  L+L  N++  LP    A L +L FL L  N
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWN 275


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  113 bits (282), Expect = 4e-25
 Identities = 92/287 (32%), Positives = 127/287 (44%), Gaps = 53/287 (18%)

Query: 65  LFLQNNLIRTLRPGTFGS--NLLTLWLF------------------------SNNLSTIY 98
           LFL NN I+ L PG F    NL  L+L                          N L+ + 
Sbjct: 113 LFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLG 172

Query: 99  PGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQ 158
            GTF  + AL  LDL +N  LR  E   FQ LE L  L+L    L+ +P N F  L SL+
Sbjct: 173 SGTFVGMVALRILDLSNNNILRISESG-FQHLENLACLYLGSNNLTKVPSNAFEVLKSLR 231

Query: 159 YLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV 218
            L L  N +  +Q   F  LANL +L L  +R+R +T   F G+ +L  L+L  N L+ +
Sbjct: 232 RLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENL 291

Query: 219 HRAAFRGL-------------------------SRLTILYLFNNSLASLPGEALADLPSL 253
           +   F  L                         + L IL L  N+L +L    L  L SL
Sbjct: 292 NSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSL 351

Query: 254 EFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLR 300
             L+ N+NPW C+C+   L  W   + + + ++ C  PP  +GR LR
Sbjct: 352 IHLQANSNPWECNCKLLGLRDWLASSAI-TLNIYCQNPPSMRGRALR 397



 Score =  108 bits (270), Expect = 9e-24
 Identities = 88/287 (30%), Positives = 139/287 (48%), Gaps = 35/287 (12%)

Query: 2   LPGLRRLLQAPASACLLLMLLALP-LAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPP 60
           LP LR  L      C LL+LL    L   S   LCT       ++C+    SS+P + P 
Sbjct: 8   LPCLRLFLVV---TCYLLLLLHKEILGCSSVCQLCTGRQ----INCRNLGLSSIPKNFPE 60

Query: 61  STQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           ST  L+L  N I  +         +L+ L+L ++N+  +YP  F  L+ L  L L +N  
Sbjct: 61  STVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNN-F 119

Query: 119 LRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQ--------------- 163
           ++ L+P  F+GL  L++L+L   Q+S +P  +F  LVS+QYL LQ               
Sbjct: 120 IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGM 179

Query: 164 ---------ENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNR 214
                     N++L + +  F  L NL+ L+L  N L  +  + F  L SL RL L  N 
Sbjct: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239

Query: 215 LQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
           ++ +   AF+GL+ L  L L N+ + ++  +  + + +L+ L L+ N
Sbjct: 240 IEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHN 286


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  112 bits (280), Expect = 6e-25
 Identities = 82/249 (32%), Positives = 122/249 (48%), Gaps = 7/249 (2%)

Query: 65  LFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
           L +Q N +  L  G F   SN+  L L  NNL+ I  G    L  L+EL L  N  +  +
Sbjct: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA-INRI 302

Query: 123 EPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLS 182
            PD ++  ++L  L L    LS L  + F GL  L  L++  N + ++ D  F  L++L 
Sbjct: 303 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLK 362

Query: 183 HLFLHGNRLRLLTEHV---FRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
            L L  N +    E +   F GL  L RL+L GNR++ + + AF GL  L  L L +N++
Sbjct: 363 TLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAI 422

Query: 240 ASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSS-SDVTCATPPERQGRD 298
            SL G A + +  L+ L LN +   CDC+ + L  W       S  + +CA P   +GR 
Sbjct: 423 MSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRS 482

Query: 299 LRALREADF 307
           + A+    F
Sbjct: 483 IFAVSPDGF 491


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  112 bits (280), Expect = 6e-25
 Identities = 82/249 (32%), Positives = 122/249 (48%), Gaps = 7/249 (2%)

Query: 65  LFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSL 122
           L +Q N +  L  G F   SN+  L L  NNL+ I  G    L  L+EL L  N  +  +
Sbjct: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA-INRI 242

Query: 123 EPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLS 182
            PD ++  ++L  L L    LS L  + F GL  L  L++  N + ++ D  F  L++L 
Sbjct: 243 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLK 302

Query: 183 HLFLHGNRLRLLTEHV---FRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
            L L  N +    E +   F GL  L RL+L GNR++ + + AF GL  L  L L +N++
Sbjct: 303 TLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAI 362

Query: 240 ASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSS-SDVTCATPPERQGRD 298
            SL G A + +  L+ L LN +   CDC+ + L  W       S  + +CA P   +GR 
Sbjct: 363 MSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRS 422

Query: 299 LRALREADF 307
           + A+    F
Sbjct: 423 IFAVSPDGF 431


>gi|153251229 chondroadherin precursor [Homo sapiens]
          Length = 359

 Score =  108 bits (270), Expect = 9e-24
 Identities = 100/342 (29%), Positives = 142/342 (41%), Gaps = 59/342 (17%)

Query: 20  MLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGT 79
           +L  L  A  +CP  C C+S    V C       +P  +   T+ L LQ N    L   +
Sbjct: 12  LLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPVLAANS 70

Query: 80  FGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLH 137
           F +  NL++L L    +  +  G FR L+ L  L L  N  +R L    F  L  L  L+
Sbjct: 71  FRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHN-DIRVLRAGAFDDLTELTYLY 129

Query: 138 LYRCQLSSLPGNI------------------------FRGLVSLQYLYLQENSLLHLQDD 173
           L   +++ LP  +                        F+G   L++LYL EN+L  LQ  
Sbjct: 130 LDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPG 189

Query: 174 LFADLANLS------------------------HLFLHGNRLRLLTEHVFRGLGS-LDRL 208
              D+ NL+                         L L  N L+ + ++ F+  G  L+ L
Sbjct: 190 ALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETL 249

Query: 209 LLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCR 268
            L    L+     AF G++ L  ++L NN L  LP     D  SLE L L  NPW C C+
Sbjct: 250 WLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFPFD--SLETLALTNNPWKCTCQ 307

Query: 269 ARPLWAWFQRARVSSSDVTCATPPERQG---RDLRALREADF 307
            R L  W + A+ S  D TCA+P + +G   RD  A R   F
Sbjct: 308 LRGLRRWLE-AKASRPDATCASPAKFKGQHIRDTDAFRSCKF 348


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score =  108 bits (269), Expect = 1e-23
 Identities = 85/255 (33%), Positives = 127/255 (49%), Gaps = 14/255 (5%)

Query: 18  LLMLLALPL---------AAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQ 68
           LL  LAL L         A P C   C+C      V C     ++VP  L   TQ L + 
Sbjct: 7   LLCFLALGLLGSAGPSGAAPPLCAAPCSC-DGDRRVDCSGKGLTAVPEGLSAFTQALDIS 65

Query: 69  NNLIRTLRPGTFGSN--LLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDT 126
            N I  L    F +   L  L L  N+LS I+P     L+ L+ L L +N+ L+++  + 
Sbjct: 66  MNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ-LKTVPSEA 124

Query: 127 FQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFL 186
            +GL  LQSL L    ++S+P + F GLV L++L+L +NSL  +     ++L  L  L L
Sbjct: 125 IRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTL 184

Query: 187 HGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEA 246
             N++  + +  F  L SL  L LH N+++ + +  F GL  L  L L  N+L   P +A
Sbjct: 185 ALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP-QA 243

Query: 247 LADLPSLEFLRLNAN 261
           +  LPSL+ L  ++N
Sbjct: 244 IKALPSLKELGFHSN 258



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 67/269 (24%), Positives = 107/269 (39%), Gaps = 37/269 (13%)

Query: 43  TVSCQANNFSSVPLSLP--PSTQRLFLQNNLIRTLRPGTFGSN--LLTLWLFSNNLSTIY 98
           T+    NN    P ++   PS + L   +N I  +  G F  N  L T+ L+ N LS + 
Sbjct: 229 TLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVG 288

Query: 99  PGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNI-------- 150
              F +L  L  L +     ++     T  G   L+SL L   ++SS+P N+        
Sbjct: 289 NSAFHNLSDLHSLVIRGASMVQQFPNLT--GTVHLESLTLTGTKISSIPNNLCQEQKMLR 346

Query: 151 --------------FRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTE 196
                         F G  +L+ + LQ N +  +++  F  L +L  L L  N +  +  
Sbjct: 347 TLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHS 406

Query: 197 HVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFL 256
             F  LG +  L +  N L         GL++L ++  F         EALA    +  L
Sbjct: 407 RAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLK------EALAAKDFVN-L 459

Query: 257 RLNANPWACDCRARPLWAWFQRARVSSSD 285
           R  + P+A  C A   W     A +++ D
Sbjct: 460 RSLSVPYAYQCCA--FWGCDSYANLNTED 486


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score =  107 bits (266), Expect = 3e-23
 Identities = 111/388 (28%), Positives = 144/388 (37%), Gaps = 103/388 (26%)

Query: 18  LLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRP 77
           LL+L A P  A  CP  C C      V+C     ++VP  +P  T+ L L  N IR L P
Sbjct: 12  LLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNP 71

Query: 78  GTFGS--------------------------NLLTLWLFSNNLSTIYPGTFRHLQALEEL 111
           G   +                           L  L L  N L  I PG F  L  L  L
Sbjct: 72  GDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLL 131

Query: 112 DLGDNR-------------HLRSLEPD----------TFQGLERLQSLHLYRCQLSSLPG 148
           DL +N+              LR LE             F GL  L+ L L RC L++L G
Sbjct: 132 DLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSG 191

Query: 149 NIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHG-------------------- 188
                L SL  L L+  ++  L+D  F  L  L HL +                      
Sbjct: 192 ESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSL 251

Query: 189 ----------------------------NRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHR 220
                                       N +  +    FR L  L  L L G  L  V  
Sbjct: 252 SVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEP 311

Query: 221 AAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRAR 280
            AF GL ++ +L L NN L++L       + +LE LR++ NP ACDCR   LW   QR +
Sbjct: 312 QAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL--LWI-VQRRK 368

Query: 281 VSSSD---VTCATPPERQGRDLRALREA 305
             + D     CATP E +G  LR L ++
Sbjct: 369 TLNFDGRLPACATPAEVRGDALRNLPDS 396


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  107 bits (266), Expect = 3e-23
 Identities = 82/253 (32%), Positives = 126/253 (49%), Gaps = 8/253 (3%)

Query: 61  STQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRH 118
           S + L +Q N I  L+ G F   +N+  L L  NNL+ +  G    L+ L++L +  N  
Sbjct: 240 SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA- 298

Query: 119 LRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADL 178
           +  + PD ++  +RL  L L   QL+ L  + F GL  L+ L L +N + H+ D +F  L
Sbjct: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358

Query: 179 ANLSHLFLHGNRLRLLTE---HVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLF 235
           +NL  L L  N +    E     F GL SL +L+L GN+++ + + AF GL  L  L L 
Sbjct: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418

Query: 236 NNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSS-DVTCATPPER 294
           NN++ S+   A +    L+ L LN +   CDC  + L  W        S +V+CA P   
Sbjct: 419 NNAIMSIQENAFSQ-THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWL 477

Query: 295 QGRDLRALREADF 307
            G+ +  +   DF
Sbjct: 478 AGQSILNVDLKDF 490



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 68/230 (29%), Positives = 106/230 (46%), Gaps = 9/230 (3%)

Query: 33  MLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSN 92
           +L   ++  P ++ QA  F        P+ + L L +N+I  ++  +F    L     SN
Sbjct: 124 LLSLVHNIIPEINAQALQFY-------PALESLDLSSNIISEIKTSSFPRMQLKYLNLSN 176

Query: 93  N-LSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIF 151
           N ++T+  G F +L +   L +  NR+  S+ P     L  LQ L L R ++  + G  F
Sbjct: 177 NRITTLEAGCFDNLSS-SLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTF 235

Query: 152 RGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLH 211
           +GL SL+ L +Q N +  L+D  F  L N+  L L  N L  + +    GL  L +L + 
Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS 295

Query: 212 GNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
            N ++ +   A+    RL+ L L  N L  L   A   L  LE L L  N
Sbjct: 296 QNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDN 345


>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
          Length = 347

 Score =  106 bits (265), Expect = 3e-23
 Identities = 100/325 (30%), Positives = 142/325 (43%), Gaps = 39/325 (12%)

Query: 17  LLLMLLALPLAAPSCPMLCTCYSSP--PTVSCQANNFSSVPLSLPPST------------ 62
           LLL+L A        P  C  + S    ++SCQ    + +P  LP  T            
Sbjct: 25  LLLLLAASAWGVTLSPKDCQVFRSDHGSSISCQPP--AEIPGYLPADTVHLAVEFFNLTH 82

Query: 63  ------------QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQAL 108
                       Q L L +N + +L P        L  L L  N L+ + PG F+    L
Sbjct: 83  LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142

Query: 109 EELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLL 168
           + L L +N+ L  LE     GL+ L  L L   +L  LP  +      L+ L L EN L 
Sbjct: 143 DTLVLKENQ-LEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLE 201

Query: 169 HLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSR 228
            L  DL      L  L L GN+L++L + +      L  L L+GN+L  V   AF+GL +
Sbjct: 202 TLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQ 261

Query: 229 LTILYLFNNSLASLPGEALADL--PSLEF---LRLNANPWACDCRARPLWAWFQRAR--- 280
           L +L L NNSLAS+P    A L  P+ +      ++ NPW CD     L+ W Q  +   
Sbjct: 262 LDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFDISGNPWICDQNLSDLYRWLQAQKDKM 321

Query: 281 VSSSDVTCATPPERQGRDLRALREA 305
            S +D  CA P   +G+ L A+ ++
Sbjct: 322 FSQNDTRCAGPEAVKGQTLLAVAKS 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,292,615
Number of Sequences: 37866
Number of extensions: 1003500
Number of successful extensions: 6175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 3633
Number of HSP's gapped (non-prelim): 963
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.