Search of human proteins with 122891862

Search of human proteins with 122891862

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
         (1274 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]           2566   0.0  
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                1856   0.0  
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...   133   9e-31
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...   133   9e-31
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]             132   3e-30
gi|29788755 SET binding factor 2 [Homo sapiens]                       105   4e-22
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]            104   6e-22
gi|239735519 SET binding factor 1 [Homo sapiens]                      100   1e-20
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               85   4e-16
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    80   1e-14
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    80   1e-14
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...    80   1e-14
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]    79   2e-14
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]    79   2e-14
gi|209863002 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862998 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862994 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|18860873 MAP-kinase activating death domain-containing protei...    77   1e-13
gi|209862987 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862983 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862979 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862975 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862971 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209571517 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             76   2e-13
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...    75   4e-13
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...    71   6e-12
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]             67   1e-10
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              66   2e-10
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap...    66   2e-10

>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score = 2566 bits (6650), Expect = 0.0
 Identities = 1274/1274 (100%), Positives = 1274/1274 (100%)

Query: 1    MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVL 60
            MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVL
Sbjct: 1    MSGSCAAPGPGSGSSPAACRFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVL 60

Query: 61   AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY 120
            AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY
Sbjct: 61   AHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFY 120

Query: 121  EEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYD 180
            EEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYD
Sbjct: 121  EEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYD 180

Query: 181  ISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP 240
            ISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP
Sbjct: 181  ISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPP 240

Query: 241  PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYS 300
            PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYS
Sbjct: 241  PGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYS 300

Query: 301  QDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLE 360
            QDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLE
Sbjct: 301  QDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLE 360

Query: 361  LPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL 420
            LPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL
Sbjct: 361  LPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTSKL 420

Query: 421  KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEK 480
            KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEK
Sbjct: 421  KNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRTGVAVEKMDLSASLGEK 480

Query: 481  DKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQN 540
            DKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQN
Sbjct: 481  DKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQN 540

Query: 541  FDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN 600
            FDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN
Sbjct: 541  FDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYN 600

Query: 601  VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQS 660
            VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQS
Sbjct: 601  VRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFPKLQS 660

Query: 661  DVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKL 720
            DVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKL
Sbjct: 661  DVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREKYMQEARSLGKNLRQPKL 720

Query: 721  SDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS 780
            SDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS
Sbjct: 721  SDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIAS 780

Query: 781  LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLP 840
            LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLP
Sbjct: 781  LCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQEHLAESPVALGPERRKSDSGVMLP 840

Query: 841  TLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRY 900
            TLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRY
Sbjct: 841  TLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRY 900

Query: 901  AFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC 960
            AFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC
Sbjct: 901  AFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSNPWIC 960

Query: 961  VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGH 1020
            VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGH
Sbjct: 961  VSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGH 1020

Query: 1021 TYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSL 1080
            TYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSL
Sbjct: 1021 TYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQKSPTTARRLSITSL 1080

Query: 1081 TGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK 1140
            TGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK
Sbjct: 1081 TGKNNKPNAGQIQEGIGEAVNNIVKHFHKPEKERGSLTVLLCGENGLVAALEQVFHHGFK 1140

Query: 1141 SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIG 1200
            SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIG
Sbjct: 1141 SARIFHKNVFIWDFIEKVVAYFETTDQILDNEDDVLIQKSSCKTFCHYVNAINTAPRNIG 1200

Query: 1201 KDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDF 1260
            KDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDF
Sbjct: 1201 KDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQTIQDF 1260

Query: 1261 TIVLEGSLIKGVDV 1274
            TIVLEGSLIKGVDV
Sbjct: 1261 TIVLEGSLIKGVDV 1274


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score = 1856 bits (4807), Expect = 0.0
 Identities = 918/1299 (70%), Positives = 1077/1299 (82%), Gaps = 47/1299 (3%)

Query: 9    GPGSGSSPAACRFAHYFVLCGIDADSGLEPDELA------------------------GE 44
            G G G   A  RFA YFV+CG+D ++GLEPDEL+                        GE
Sbjct: 3    GGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGE 62

Query: 45   NFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFII 104
            NF+Q+PLRRTFKSKVLA YP+N+EWNPFDQDAV MLCMPKGL+F+TQ D ++PQFH+FII
Sbjct: 63   NFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFII 122

Query: 105  TREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDE 164
            TREDGSRT+GF LTFYEEVTSKQIC+AMQTLY MHNAE Y  ++A  +   D   SS+++
Sbjct: 123  TREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAE-YDVLHAPPADDRDQ--SSMED 179

Query: 165  GDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLP 224
            G+ T + KLQR+NSYDISRDTLYVSK ICLITP+ FM+AC+  L QL++AVTS QPPPLP
Sbjct: 180  GEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLP 239

Query: 225  LESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLV 284
            LESYI+N+LYEVPLPPPGRSLKF GVY P+ICQRP  +ELPL D+P++E FELLG+EN+ 
Sbjct: 240  LESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVF 299

Query: 285  QVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPY 344
            Q+FTC LLE QILLYSQ YQRLMTVAE IT L+FPFQWQHVYVPILPASLLHFLDAPVPY
Sbjct: 300  QLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPY 359

Query: 345  LMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFG 404
            LMGL S    DRSKLELPQEANLCFVDIDNHFIELPE+ PQFPNK++F+QE+SE+L+ FG
Sbjct: 360  LMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFG 419

Query: 405  IPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRT 464
            IPPEG+LHCSES SKLK +   +LV+DK+NGN+  + +  YELLK NETIARLQAL KRT
Sbjct: 420  IPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRT 479

Query: 465  GVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQT 524
            GV++EK+++       +KDLK+ C+E ELR YQLN+Q+REVFANRFTQMFADYE FVIQ 
Sbjct: 480  GVSLEKLEVRED-PSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQP 538

Query: 525  AQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIM-SQWEEKD 583
            +QD ESW TNREQMQNFDKASFLSDQPEPYLPFLSRF+ETQMFA+FIDNKIM    ++KD
Sbjct: 539  SQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKD 598

Query: 584  PLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDM 643
            P+LRVFD+R+DKIRL NVR PTLRTS+YQKC+T+ EA ++IE RL K+DHTAIHPHLLDM
Sbjct: 599  PVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDM 658

Query: 644  KIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQ-RRKERLRQHSEHVGLDNDLRE 702
            KIGQGKYE GFFPKLQSDVL+TGP S N+W  R+A AQ RRK+R +QH+EH+ LDND RE
Sbjct: 659  KIGQGKYEPGFFPKLQSDVLSTGPAS-NKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQRE 717

Query: 703  KYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVEL 762
            KY+QEAR++G  +RQPKLS+LSP+VIAQTN KFVEGLLKECR KTKRMLVEKMG EAVEL
Sbjct: 718  KYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVEL 777

Query: 763  GHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQ---EHL 819
            GHGE NITG+EENTLIASLCDLLERIWSHGLQVKQGKSALWSHL+ +QD  +++     L
Sbjct: 778  GHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSL 837

Query: 820  AESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLL 879
            + S + L  ERRKSD+  ++P LR+SLIQDMRHIQN+ EIKTDVG+ARAW+RLS+EKKLL
Sbjct: 838  STSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLL 897

Query: 880  SQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYR 939
            S+HLKQLLS+  LTKKLYKRYAFLRC++E+EQFLYHLLS NAVDYFCFT+VFTTI+IPY 
Sbjct: 898  SRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYH 957

Query: 940  SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDN 999
             +I+P KKL  ++ T+NPWIC+SGELG+T +MQIP+N+LEMTFECQNLGKLTTVQIGHDN
Sbjct: 958  ILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDN 1017

Query: 1000 SGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQ 1059
            SGL AKWLV+ VMVRNEITGHTY+FPCGRWLGKG+DDGSLERIL+GEL+TS  + D  + 
Sbjct: 1018 SGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVD-ERP 1076

Query: 1060 CRTPPQQKSPTTARRLSITSLTGKNNKP--NAGQIQEGIGEAVNNIVKHFHKPEKERGSL 1117
            CRTPP Q+SP+  RRL   S    NNKP  N GQIQE IGEAVN IVKHFHKPEKERGSL
Sbjct: 1077 CRTPPLQQSPSVIRRLVTIS---PNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSL 1133

Query: 1118 TVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFIEKVVAYFETTD--QILDNEDDV 1175
            T+LLCGE GLV+ALEQ F HGFKS R+F KNVFIWDF+EK   Y+ET +  +++  E+  
Sbjct: 1134 TLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFLEKAQTYYETLEKNEVVPEEN-- 1190

Query: 1176 LIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMY 1235
                +  + FC +V AIN  PRNIGKDGKFQ+LVCLG RD LL  WI LLA+CP    MY
Sbjct: 1191 --WHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMY 1248

Query: 1236 EESALLRDRMTVNSLIRILQTIQDFTIVLEGSLIKGVDV 1274
            E+ AL++D   VNSLIR+LQT+Q+F I LE SL+KG+D+
Sbjct: 1249 EDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI 1287


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
           sapiens]
          Length = 1906

 Score =  133 bits (335), Expect = 9e-31
 Identities = 128/550 (23%), Positives = 226/550 (41%), Gaps = 111/550 (20%)

Query: 54  TFKSKVLAHYPQNIEWNPFD-QDAVNMLCMPKGLSFRTQTDNKD---PQFHSFIITREDG 109
           ++K+ ++  YPQ  ++  F   ++V + C+P G +      N     P F +F++T    
Sbjct: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265

Query: 110 SRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTS 169
            + YG  + FYE  + + +    + L  + +A+  S                        
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSD----------------------- 302

Query: 170 LLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYI 229
                       S  T++ +K ICL++  PF  A +KFL  LY+   S  P  LP+E +I
Sbjct: 303 ------------SSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHI 349

Query: 230 HNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
            + +++VP P P R   L     ++ +I  +P  S LPLS        + LG EN V + 
Sbjct: 350 SHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLL 409

Query: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
              + E +IL++S     L +V E + +++FPF W   YVP+ P +L   L AP P+++G
Sbjct: 410 VFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVG 469

Query: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPP 407
                                   ID+ + +L +     P  V  +   +  + Q G   
Sbjct: 470 ------------------------IDSRYFDLYDP----PPDVSCVDVDTNTISQIG--- 498

Query: 408 EGSLHCSESTSKLKNMVLKDLVNDK-KNGNVCTNNISMYELLKGNETIARLQALAKRTGV 466
                        KN+  K L     KN     NN+        ++ +A+LQ   +  G+
Sbjct: 499 -----------DKKNVAWKILPKKPCKNLMNTLNNL--------HQQLAKLQQRPRDDGL 539

Query: 467 AVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQ 526
               MDL+ +  + +   +LH          ++++++E F      +   Y +++    Q
Sbjct: 540 ----MDLAINDYDFNSGKRLH---------MIDLEIQEAFLFFMASILKGYRSYLRPITQ 586

Query: 527 DMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLL 586
                 T+   +  F   +FL  +   +  F +   +TQMF  FI+    S   +KD  L
Sbjct: 587 APSETATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE--CSFVSDKDASL 642

Query: 587 RVFDTRIDKI 596
             FD  +DK+
Sbjct: 643 AFFDDCVDKV 652


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
           sapiens]
          Length = 1863

 Score =  133 bits (335), Expect = 9e-31
 Identities = 128/550 (23%), Positives = 226/550 (41%), Gaps = 111/550 (20%)

Query: 54  TFKSKVLAHYPQNIEWNPFD-QDAVNMLCMPKGLSFRTQTDNKD---PQFHSFIITREDG 109
           ++K+ ++  YPQ  ++  F   ++V + C+P G +      N     P F +F++T    
Sbjct: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265

Query: 110 SRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTS 169
            + YG  + FYE  + + +    + L  + +A+  S                        
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSD----------------------- 302

Query: 170 LLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYI 229
                       S  T++ +K ICL++  PF  A +KFL  LY+   S  P  LP+E +I
Sbjct: 303 ------------SSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHI 349

Query: 230 HNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
            + +++VP P P R   L     ++ +I  +P  S LPLS        + LG EN V + 
Sbjct: 350 SHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLL 409

Query: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
              + E +IL++S     L +V E + +++FPF W   YVP+ P +L   L AP P+++G
Sbjct: 410 VFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVG 469

Query: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPP 407
                                   ID+ + +L +     P  V  +   +  + Q G   
Sbjct: 470 ------------------------IDSRYFDLYDP----PPDVSCVDVDTNTISQIG--- 498

Query: 408 EGSLHCSESTSKLKNMVLKDLVNDK-KNGNVCTNNISMYELLKGNETIARLQALAKRTGV 466
                        KN+  K L     KN     NN+        ++ +A+LQ   +  G+
Sbjct: 499 -----------DKKNVAWKILPKKPCKNLMNTLNNL--------HQQLAKLQQRPRDDGL 539

Query: 467 AVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQ 526
               MDL+ +  + +   +LH          ++++++E F      +   Y +++    Q
Sbjct: 540 ----MDLAINDYDFNSGKRLH---------MIDLEIQEAFLFFMASILKGYRSYLRPITQ 586

Query: 527 DMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLL 586
                 T+   +  F   +FL  +   +  F +   +TQMF  FI+    S   +KD  L
Sbjct: 587 APSETATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE--CSFVSDKDASL 642

Query: 587 RVFDTRIDKI 596
             FD  +DK+
Sbjct: 643 AFFDDCVDKV 652


>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score =  132 bits (331), Expect = 3e-30
 Identities = 144/616 (23%), Positives = 245/616 (39%), Gaps = 138/616 (22%)

Query: 97  PQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMD 156
           P F +F++T     + YG  + FYE   S+++ +  Q ++                    
Sbjct: 17  PVFSTFVLTGSSAKKVYGAAIQFYEPY-SRELLSEKQLMH-------------------- 55

Query: 157 SLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVT 216
                         L L       +   ++  +K ICL++  PF +A +KFL+ +YK   
Sbjct: 56  --------------LGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSV 101

Query: 217 SQQPPPLPLESYIHNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREA 274
           S  P PLP+E +I + +  +P P P R   L    V++ +I  +P  + LPLS       
Sbjct: 102 SG-PHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTL 160

Query: 275 FELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASL 334
              LG EN   +   VLLE +ILL+S     L  VAE +  ++FPFQWQ  Y+P+ P SL
Sbjct: 161 LMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSL 220

Query: 335 LHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQ 394
              L AP+P+++G+ S+       L  P +  +C +D+D + + + +E            
Sbjct: 221 AAVLSAPLPFIVGVDSR----YFDLHDPPQDVVC-IDLDTNMLYVSDE------------ 263

Query: 395 ELSEVLVQFGIPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETI 454
                                     KNM  K L         C N +S  + L      
Sbjct: 264 -------------------------KKNMNWKQLPK-----KPCKNLLSTLKKL-----Y 288

Query: 455 ARLQALAKRT--GVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQ 512
            +L ++ ++T  G A++   + A    + K              QL ++++E F      
Sbjct: 289 PQLSSVHQKTQEGSAIDMTPIEADFSWQKKMT------------QLEMEIQEAFLRFMAS 336

Query: 513 MFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFID 572
           +   Y  ++    +   +  T  + +  FD+  FL  +   Y  F +   +TQ+F  FI+
Sbjct: 337 ILKGYRTYLRPITEAPSNKATAADSL--FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIE 394

Query: 573 NKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMD 632
               S   +KD  L  FD  I+K+       P   T    K     +   + + RL+++D
Sbjct: 395 E--CSFVSDKDTGLAFFDDCIEKL------FPDKGTEKTDKV----DFDSAEDTRLIELD 442

Query: 633 HTAIHPHLL----------DMKIGQGKYEQGFFPKLQSDV----------LATGPTSNNR 672
            +    H +          D K    KY   +FP+L   +           +  PT N+ 
Sbjct: 443 DSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSI 502

Query: 673 WVSRSATAQRRKERLR 688
             S    A+R K+ ++
Sbjct: 503 TKSPPLMAKRTKQEIK 518


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score =  105 bits (261), Expect = 4e-22
 Identities = 93/366 (25%), Positives = 159/366 (43%), Gaps = 68/366 (18%)

Query: 20  RFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVLAHYPQNIEWN--PFDQDAV 77
           R A YF++ G D +   +P   +GE             K++  +PQ  +W+  PF Q  +
Sbjct: 3   RLADYFIVVGYDHE---KPG--SGEGL----------GKIIQRFPQK-DWDDTPFPQ-GI 45

Query: 78  NMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQ 137
            + C P G  ++   + K P F   ++T  D  R Y   LTFYE   + Q          
Sbjct: 46  ELFCQPGG--WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQ---------- 93

Query: 138 MHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITP 197
                                      G     ++ +   S  I    ++  KS+ L++ 
Sbjct: 94  ---------------------------GTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSR 126

Query: 198 LPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFY--GVYEPVI 255
           L + +  +  L  +Y          + LES I N L    +P  G S K +  G  +  +
Sbjct: 127 LYYPEIFRACLGLIYTVYVDSLN--VSLESLIAN-LCACLVPAAGGSQKLFSLGAGDRQL 183

Query: 256 CQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITT 315
            Q P    LP++   +   F+ LG++N++ +F  VL E ++L +S  +QRL      + +
Sbjct: 184 IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALES 243

Query: 316 LLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           L+FP ++ + Y+PILPA LL  L +P P+++G+ S   TD  +L      ++   D+D  
Sbjct: 244 LMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHEL-----LDVIIADLDGG 298

Query: 376 FIELPE 381
            I++PE
Sbjct: 299 TIKIPE 304


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score =  104 bits (259), Expect = 6e-22
 Identities = 84/334 (25%), Positives = 148/334 (44%), Gaps = 46/334 (13%)

Query: 55  FKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFR---TQTDNKDPQFHSFIITREDGSR 111
           +++++L  YP+         ++V + C+P G +      QT    P F +F++T   G +
Sbjct: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270

Query: 112 TYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLL 171
            YG  L FYE     ++                    +        L S+++ G      
Sbjct: 271 VYGAALQFYEAFPRARL--------------------SERQARALGLLSAVERGRA---- 306

Query: 172 KLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHN 231
                    +    +   ++I +++  P   A + FL  LY+   S  P  LPLE++I +
Sbjct: 307 ---------LGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSG-PHRLPLEAHISH 356

Query: 232 ILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTC 289
            ++ VP P P R   L     Y+ ++  +P  S LPLS     +  + LG E  + +   
Sbjct: 357 FIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLA 416

Query: 290 VLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQ 349
           VL E ++L++S     L +V E + +++FP  WQ  Y+P+ P  L   L APVP+++G+ 
Sbjct: 417 VLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIH 476

Query: 350 SKEGTDRSKLEL-PQEANLCFVDIDNHFIELPEE 382
           S      S  +L    A++  VD+D + +   EE
Sbjct: 477 S------SYFDLHDPPADVICVDLDTNTLFQTEE 504


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  100 bits (248), Expect = 1e-20
 Identities = 88/358 (24%), Positives = 150/358 (41%), Gaps = 44/358 (12%)

Query: 56  KSKVLAHYPQNIEW--NPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTY 113
           + ++L  +P+  +W  NPF Q  + + C P G  ++   +   P F   ++T  +  R Y
Sbjct: 24  QGQILQRFPEK-DWEDNPFPQ-GIELFCQPSG--WQLCPERNPPTFFVAVLTDINSERHY 79

Query: 114 GFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKL 173
              LTF+E     Q  T ++   +                         DEG  T L   
Sbjct: 80  CACLTFWEPAEPSQETTRVEDATEREEEG--------------------DEGGQTHLSPT 119

Query: 174 QRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNIL 233
               S       L+  K++ L++ L   +  +  L  +Y      +   + LE+ I N+L
Sbjct: 120 APAPSAQ-----LFAPKTLVLVSRLDHTEVFRNSLGLIY--AIHVEGLNVCLENVIGNLL 172

Query: 234 -YEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLL 292
              VPL    +     G  +  + Q P    LP+S   +   F  LG+ N++ +F   L 
Sbjct: 173 TCTVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALT 232

Query: 293 EMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKE 352
           E ++L  S+ YQRL     G+  LLFP ++   YVPILPA LL  L  P P+++G+ +  
Sbjct: 233 EHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAF 292

Query: 353 GTDRSKLELPQEANLCFVDIDNHFIELPE--EFPQFPNKVDFIQELSEVLVQFGIPPE 408
             +  +L      ++   D+D   + +PE    P  P     +Q  +  ++   + PE
Sbjct: 293 QAETQEL-----LDVIVADLDGGTVTIPECVHIPPLPEP---LQSQTHSVLSMVLDPE 342


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 75/304 (24%), Positives = 119/304 (39%), Gaps = 67/304 (22%)

Query: 80  LCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMH 139
           LC P G+   T+   K+   H  ++T   G+RTYG V  +Y  +  +         Y  +
Sbjct: 45  LCFPGGVCVATEP--KEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDE---------YCFY 93

Query: 140 NAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLP 199
           N + +        C +                         +SR   Y S   CL   L 
Sbjct: 94  NGKTHREC---PGCFVPFAVCV-------------------VSRFPYYNSLKDCLSCLLA 131

Query: 200 FMQACKKFLIQLY------KAVTSQQPPPLPLESYIHNILYEVPLPP---PGRSLKFYGV 250
            ++ CK F +  +      K      PPP PL    +    ++ LP    P   +    +
Sbjct: 132 LLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDL 191

Query: 251 YEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVA 310
           + P++C RP                     E ++Q+ TC+L E +I+ +S D+  L  V 
Sbjct: 192 HLPLLCFRP---------------------EKVLQILTCILTEQRIVFFSSDWALLTLVT 230

Query: 311 EGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFV 370
           E     L+P QWQH +VPIL   +L F+ AP  +LMG       + SK    +   L  +
Sbjct: 231 ECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSK----EADGLVLI 286

Query: 371 DIDN 374
           +ID+
Sbjct: 287 NIDH 290


>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo
           sapiens]
          Length = 1137

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 8/163 (4%)

Query: 233 LYEVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
           L E P P PG+++K          E +  +RP  S L   D+     F  L +  L+++F
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890

Query: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
             +LLE +++  +     L + +  +  LL+PF WQH ++P+LPAS++  +  P P+L+G
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950

Query: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKV 390
           L S       +L + +EA +  +  D    ++ +E    P K+
Sbjct: 951 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKL 992



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 26/98 (26%), Positives = 46/98 (46%), Gaps = 13/98 (13%)

Query: 498  LNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPF 557
            LN  + EVF   F +    Y  F+ Q+ +   ++     Q + F K    S   +    F
Sbjct: 1022 LNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAF-----QREAFRK----SVASKSIRRF 1072

Query: 558  LSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDK 595
            L  F+E+QMFA FI ++ + +   K     +F+ R+++
Sbjct: 1073 LEVFMESQMFAGFIQDRELRKCRAKG----LFEQRVEQ 1106


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo
           sapiens]
          Length = 1137

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 8/163 (4%)

Query: 233 LYEVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
           L E P P PG+++K          E +  +RP  S L   D+     F  L +  L+++F
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890

Query: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
             +LLE +++  +     L + +  +  LL+PF WQH ++P+LPAS++  +  P P+L+G
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950

Query: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKV 390
           L S       +L + +EA +  +  D    ++ +E    P K+
Sbjct: 951 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKL 992



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 26/98 (26%), Positives = 46/98 (46%), Gaps = 13/98 (13%)

Query: 498  LNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPF 557
            LN  + EVF   F +    Y  F+ Q+ +   ++     Q + F K    S   +    F
Sbjct: 1022 LNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAF-----QREAFRK----SVASKSIRRF 1072

Query: 558  LSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDK 595
            L  F+E+QMFA FI ++ + +   K     +F+ R+++
Sbjct: 1073 LEVFMESQMFAGFIQDRELRKCRAKG----LFEQRVEQ 1106


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
           sapiens]
          Length = 717

 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 8/163 (4%)

Query: 233 LYEVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
           L E P P PG+++K          E +  +RP  S L   D+     F  L +  L+++F
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 470

Query: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
             +LLE +++  +     L + +  +  LL+PF WQH ++P+LPAS++  +  P P+L+G
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530

Query: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKV 390
           L S       +L + +EA +  +  D    ++ +E    P K+
Sbjct: 531 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKL 572



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 26/98 (26%), Positives = 46/98 (46%), Gaps = 13/98 (13%)

Query: 498 LNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPF 557
           LN  + EVF   F +    Y  F+ Q+ +   ++     Q + F K    S   +    F
Sbjct: 602 LNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAF-----QREAFRK----SVASKSIRRF 652

Query: 558 LSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDK 595
           L  F+E+QMFA FI ++ + +   K     +F+ R+++
Sbjct: 653 LEVFMESQMFAGFIQDRELRKCRAKG----LFEQRVEQ 686


>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
          Length = 559

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 61/240 (25%), Positives = 109/240 (45%), Gaps = 13/240 (5%)

Query: 155 MDSLA-SSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYK 213
           +DSL  S + +  T  L  +     +   R +       C+++ LP+ +   K L  L  
Sbjct: 59  VDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILAD 118

Query: 214 AVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPL--SDYPL 271
             T +Q       + +   L+++P+P PG S+    V+       P   ELP    +  L
Sbjct: 119 YTTKRQENQW---NELLETLHKLPIPDPGVSVHL-SVHSYFTV--PDTRELPSIPENRNL 172

Query: 272 REAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILP 331
            E F  + + N++ ++  +L E +IL+       L     G   +L+P  WQHVY+P+LP
Sbjct: 173 TEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLP 232

Query: 332 ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELP-EEFPQFPNKV 390
             LL +  AP+PYL+G+          + L    ++  +++D + +E P ++    PN V
Sbjct: 233 PHLLDYCCAPMPYLIGIHLSLMEKVRNMALD---DVVILNVDTNTLETPFDDLQSLPNDV 289


>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
          Length = 1009

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 61/240 (25%), Positives = 109/240 (45%), Gaps = 13/240 (5%)

Query: 155 MDSLA-SSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYK 213
           +DSL  S + +  T  L  +     +   R +       C+++ LP+ +   K L  L  
Sbjct: 59  VDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILAD 118

Query: 214 AVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPL--SDYPL 271
             T +Q       + +   L+++P+P PG S+    V+       P   ELP    +  L
Sbjct: 119 YTTKRQENQW---NELLETLHKLPIPDPGVSVHL-SVHSYFTV--PDTRELPSIPENRNL 172

Query: 272 REAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILP 331
            E F  + + N++ ++  +L E +IL+       L     G   +L+P  WQHVY+P+LP
Sbjct: 173 TEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLP 232

Query: 332 ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELP-EEFPQFPNKV 390
             LL +  AP+PYL+G+          + L    ++  +++D + +E P ++    PN V
Sbjct: 233 PHLLDYCCAPMPYLIGIHLSLMEKVRNMALD---DVVILNVDTNTLETPFDDLQSLPNDV 289


>gi|209863002 MAP-kinase activating death domain-containing protein
           isoform j [Homo sapiens]
          Length = 1541

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862998 MAP-kinase activating death domain-containing protein
           isoform i [Homo sapiens]
          Length = 1544

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862994 MAP-kinase activating death domain-containing protein
           isoform d [Homo sapiens]
          Length = 1647

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|18860873 MAP-kinase activating death domain-containing protein
           isoform g [Homo sapiens]
          Length = 1581

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862987 MAP-kinase activating death domain-containing protein
           isoform f [Homo sapiens]
          Length = 1479

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862983 MAP-kinase activating death domain-containing protein
           isoform e [Homo sapiens]
          Length = 1608

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862979 MAP-kinase activating death domain-containing protein
           isoform c [Homo sapiens]
          Length = 1545

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862975 MAP-kinase activating death domain-containing protein
           isoform b [Homo sapiens]
          Length = 1565

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209862971 MAP-kinase activating death domain-containing protein
           isoform a [Homo sapiens]
          Length = 1588

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|209571517 MAP-kinase activating death domain-containing protein
           isoform h [Homo sapiens]
          Length = 1587

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344

Query: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402

Query: 376 FIELPEEFPQFP 387
            +  P      P
Sbjct: 403 RVIAPTNAEVLP 414


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 17/220 (7%)

Query: 193 CLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVY- 251
           C+++ L       K L ++ K    ++  P  +  ++ +++ E P P PGR++       
Sbjct: 535 CMVSRLGCFNLFSKILDEVEKR---REMSPALVYPFMRSVM-EAPFPAPGRTITVKSYLP 590

Query: 252 ----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLM 307
               E +   RP  S L   D+     F+ L + +L++V   +LLE +++  +     L 
Sbjct: 591 GAGDESIELCRPLDSRLEHVDFKC--LFKCLSVCHLIRVCASLLLERRVIFVANSLSTLS 648

Query: 308 TVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANL 367
                +   L+PF WQH Y+P+LPAS++  + +P P+L+G+ S        L + +E  +
Sbjct: 649 KCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPI-EEVLI 707

Query: 368 CFVDIDNHFIELPEEFPQFPNK-----VDFIQELSEVLVQ 402
             +  D    E+ +E    P K     +  ++E +E+L Q
Sbjct: 708 VDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQ 747


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
           sapiens]
          Length = 755

 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 53/198 (26%), Positives = 94/198 (47%), Gaps = 25/198 (12%)

Query: 192 ICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNIL---YEVPLP----PPGRS 244
           +C+++ LP+ +   K L  L   +  +      LE+ ++  L   Y  P+P    P   S
Sbjct: 95  LCILSYLPWFEVYYKLLNTLADYLAKE------LENDLNETLRSLYNHPVPKANTPVNLS 148

Query: 245 LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQ 304
           +  Y +   V      P    L++Y     F  + + N++Q++  +L E +I++ S    
Sbjct: 149 VHSYFIAPDVTGLPTIPESRNLTEY-----FVAVDVNNMLQLYASMLHERRIVIISSKLS 203

Query: 305 RLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSK--EGTDRSKLELP 362
            L     G   LL+P  WQH+Y+P+LP  LL +  AP+PYL+G+ S   E      LE  
Sbjct: 204 TLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLE-- 261

Query: 363 QEANLCFVDIDNHFIELP 380
              ++  +++D + +E P
Sbjct: 262 ---DVVMLNVDTNTLESP 276


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
           sapiens]
          Length = 426

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 36/112 (32%), Positives = 61/112 (54%), Gaps = 7/112 (6%)

Query: 271 LREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPIL 330
           L E F  + + N++Q++  +L E +I++ S     L     G   LL+P  WQH+Y+P+L
Sbjct: 190 LTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 249

Query: 331 PASLLHFLDAPVPYLMGLQSK--EGTDRSKLELPQEANLCFVDIDNHFIELP 380
           P  LL +  AP+PYL+G+ S   E      LE     ++  +++D + +E P
Sbjct: 250 PPHLLDYCCAPMPYLIGIHSSLIERVKNKSLE-----DVVMLNVDTNTLESP 296


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 46/167 (27%), Positives = 79/167 (47%), Gaps = 10/167 (5%)

Query: 235 EVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTC 289
           E P P  G+++           E +   RP  S L   D+     F  L + +LV VF  
Sbjct: 704 EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVFAS 761

Query: 290 VLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQ 349
           +LLE +++  +     L      +  L++PF WQH Y+P+LP +++  + +P P+L+GL 
Sbjct: 762 LLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLL 821

Query: 350 SKEGTDRSKLELPQEANLCFVDIDNHFI-ELPEEFPQFPNKVDFIQE 395
           S   +     ELP E  L    +++ F+ ++ +E    P K+    E
Sbjct: 822 S--SSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 69/304 (22%), Positives = 108/304 (35%), Gaps = 82/304 (26%)

Query: 76  AVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTL 135
           A+ + C P G  + + T+     F SF++T  DGSR  G+                 + L
Sbjct: 99  AIPLFCFPDGNEWASLTEYPRETF-SFVLTNVDGSRKIGYC----------------RRL 141

Query: 136 YQMHNAEHYSSVYASSSC--SMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSIC 193
                      VY   SC       +  LDE +            + IS   +Y      
Sbjct: 142 LPAGPGPRLPKVYCIISCIGCFGLFSKILDEVE----------KRHQISMAVIY------ 185

Query: 194 LITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVY-- 251
                PFMQ                              L E   P PG+++        
Sbjct: 186 -----PFMQG-----------------------------LREAAFPAPGKTVTLKSFIPD 211

Query: 252 ---EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMT 308
              E +   RP  S L   D+        L  E ++Q+F   +LE +I+  ++    L  
Sbjct: 212 SGTEFISLTRPLDSHLEHVDFS--SLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQ 269

Query: 309 VAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQE---- 364
                  LL+PF W H Y+P++P SLL  +  P P+++G+Q +    +  ++ P E    
Sbjct: 270 CIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMR--FQQEVMDSPMEEVLL 327

Query: 365 ANLC 368
            NLC
Sbjct: 328 VNLC 331


>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sapiens]
          Length = 1114

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 46/122 (37%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 940  SVIIPIKKLSNAIITSNPWICVSGELGDTGVM----------QIPKNLLEM-TFECQNLG 988
            SV I      NA   +N +I + G   DTG+           +  ++ +E+ T E  +LG
Sbjct: 67   SVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLG 126

Query: 989  KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILI-GEL 1047
             L  V++GHDN+G    W VD V V     G    FPCGRWL K  DDGS+ R L   EL
Sbjct: 127  DLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAEL 186

Query: 1048 MT 1049
             T
Sbjct: 187  QT 188



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 47/152 (30%), Positives = 72/152 (47%), Gaps = 22/152 (14%)

Query: 958  WICVSGELGDTGVMQIPK-----NLLEM----TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
            +I + G+LGDTG   + K     N  E     TF  E  +LG +  +++ HDNS   A W
Sbjct: 370  YITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADW 429

Query: 1007 LVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQCRTPPQQ 1066
             V+ V + N+     + F CGRWL    +DG LER+   +  T     D    C +P   
Sbjct: 430  YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTG----DRSSNCSSPADF 485

Query: 1067 KSPTTARRLS---ITSLTGKNNKPNAGQIQEG 1095
                 + +++   I+++TG    P A  +QEG
Sbjct: 486  WEIALSSKMADVDISTVTG----PMADYVQEG 513



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 31/113 (27%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 940  SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQN-----------LG 988
            +V +    +  A   +N +I + GE GD+G + + ++     FE  N           LG
Sbjct: 777  TVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLG 836

Query: 989  KLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLER 1041
             L  +++ HDN G+   W +  V V++     T+ F C  WL K   DG   R
Sbjct: 837  HLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 889



 Score = 38.1 bits (87), Expect = 0.054
 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 5/75 (6%)

Query: 975  KNLLEMTFECQNLGKLTT-VQIGHDNSGLLAKWLVDCVMVRNEIT----GHTYRFPCGRW 1029
            K+      E +++G++   ++IGH+N+G+   W    V +R  +       T  FPC RW
Sbjct: 246  KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRW 305

Query: 1030 LGKGIDDGSLERILI 1044
            L    DD    R L+
Sbjct: 306  LATSEDDKKTIRELV 320



 Score = 35.8 bits (81), Expect = 0.27
 Identities = 16/57 (28%), Positives = 28/57 (49%)

Query: 986  NLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERI 1042
            ++G +  +++GHD +   + WLV+ + +     G  Y   C  WL K   DG   R+
Sbjct: 576  DVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRV 632



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 3/32 (9%)

Query: 1013 VRNEITGHTYRFPCGRWLGKGIDDGSLERILI 1044
            + NEIT   Y FPC RWL    DDG L R L+
Sbjct: 1    MNNEIT---YYFPCQRWLAVEEDDGQLSRELL 29



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 16/114 (14%)

Query: 955  SNPWICVSGELGDTGVMQIPKNLLEM------TF--ECQNLGKLTTVQIGHDNSGLLAKW 1006
            SN ++ + G  G T  MQ+ K           TF  E  ++   T ++I  D  G   +W
Sbjct: 665  SNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 724

Query: 1007 LVDCVMVRNEITGHTYRFPCGRWLG--KGIDDGSLERILIGELMTSASDEDLVK 1058
             ++ ++++N  TG    F  G WL   KG      ++ L+ E+     +E++++
Sbjct: 725  FLERILLKNMNTGDLTMFYYGDWLSQRKG------KKTLVCEMCAVIDEEEMME 772


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,820,749
Number of Sequences: 37866
Number of extensions: 2241750
Number of successful extensions: 5956
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5762
Number of HSP's gapped (non-prelim): 191
length of query: 1274
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1160
effective length of database: 13,930,794
effective search space: 16159721040
effective search space used: 16159721040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.