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Search of human proteins with 28461129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo
sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo sa... 898 0.0
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 69 8e-12
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 69 1e-11
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 68 2e-11
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 67 2e-11
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 67 2e-11
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 66 6e-11
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 66 6e-11
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 64 2e-10
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 64 4e-10
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 62 8e-10
gi|16975496 cortactin binding protein 2 [Homo sapiens] 62 8e-10
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 62 1e-09
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 62 1e-09
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 61 2e-09
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 61 2e-09
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 61 2e-09
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 61 2e-09
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 61 2e-09
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 61 2e-09
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 61 2e-09
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 60 3e-09
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 60 3e-09
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 60 3e-09
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 60 3e-09
gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa... 60 5e-09
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens] 60 5e-09
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 60 5e-09
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 60 5e-09
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 60 5e-09
>gi|28461129 ankyrin repeat and MYND domain containing 2 [Homo
sapiens]
Length = 441
Score = 898 bits (2321), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLD 60
MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLD
Sbjct: 1 MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLD 60
Query: 61 MCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
MCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA
Sbjct: 61 MCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
Query: 121 AFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVM 180
AFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVM
Sbjct: 121 AFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVM 180
Query: 181 LVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCINFLKDGE 240
LVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCINFLKDGE
Sbjct: 181 LVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCINFLKDGE 240
Query: 241 NKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTA 300
NKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTA
Sbjct: 241 NKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTA 300
Query: 301 FSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNL 360
FSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNL
Sbjct: 301 FSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNL 360
Query: 361 KDIYEKQQLEAAKEKRQEENHGKLDVNSNCVNEEQPEAEVGISQKDSNPEDSGEGKKESL 420
KDIYEKQQLEAAKEKRQEENHGKLDVNSNCVNEEQPEAEVGISQKDSNPEDSGEGKKESL
Sbjct: 361 KDIYEKQQLEAAKEKRQEENHGKLDVNSNCVNEEQPEAEVGISQKDSNPEDSGEGKKESL 420
Query: 421 ESEAELEGLQDAPAGPQVSEE 441
ESEAELEGLQDAPAGPQVSEE
Sbjct: 421 ESEAELEGLQDAPAGPQVSEE 441
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 68.9 bits (167), Expect = 8e-12
Identities = 46/122 (37%), Positives = 63/122 (51%), Gaps = 4/122 (3%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKG-KLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
L +K V+ +D+NGMTPLM AAY+ +D +LLL VN H TAL +A L+
Sbjct: 176 LIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLA 235
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFFPRERLDYYTKPQGL 150
GN + ++LEAGA D N G +A +A Q V +IN+ + Y P L
Sbjct: 236 GNTTVISLLLEAGANVDAQNIKGESALDLAK---QRKNVWMINHLQEARQAKGYDNPSFL 292
Query: 151 DK 152
K
Sbjct: 293 RK 294
Score = 37.0 bits (84), Expect = 0.036
Identities = 23/75 (30%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETD 107
TPL A +G L M L+++GAD + E G + + AA G+ I ++ G + D
Sbjct: 126 TPLHWATRQGHLSMVVQLMKYGADPSLIDGE-GCSCIHLAAQFGHTSIVAYLIAKGQDVD 184
Query: 108 VVNSVGRTAAQMAAF 122
+++ G T AA+
Sbjct: 185 MMDQNGMTPLMWAAY 199
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 68.6 bits (166), Expect = 1e-11
Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGA 70
+ +++LLE + +G V L S K+ R LD NG +P AA KG + +LL +GA
Sbjct: 19 RHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGA 78
Query: 71 DVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVT 130
D+N ++E G TAL A +S V+L+ GA D V++ R+ AA G V
Sbjct: 79 DIN-SKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVL 137
Query: 131 II 132
++
Sbjct: 138 LL 139
Score = 37.4 bits (85), Expect = 0.027
Identities = 22/62 (35%), Positives = 33/62 (53%), Gaps = 1/62 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L + RVN D+N + L+ A KG ++ +LLL HGAD G+ AL +A +
Sbjct: 172 LLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGA-VDSTGHDALHYALHTQ 230
Query: 92 NK 93
+K
Sbjct: 231 DK 232
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 67.8 bits (164), Expect = 2e-11
Identities = 38/99 (38%), Positives = 53/99 (53%), Gaps = 1/99 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL +K +N D+ L AAY G LD+ LL+ HGA+V C + + GYT L
Sbjct: 129 EMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC-KDKKGYTPLHA 187
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQ 125
AA +G ++ +L G E D +N G TA +A + GQ
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Score = 52.4 bits (124), Expect = 8e-07
Identities = 38/104 (36%), Positives = 52/104 (50%), Gaps = 5/104 (4%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LLSS NV D G T L HAA G ++M LLL GA++N + AL +AA
Sbjct: 104 LLSSVNVS----DRGGRTALHHAALNGHVEMVNLLLAKGANINAFD-KKDRRALHWAAYM 158
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
G+ D+ +++ GAE + G T AA GQ + V + N
Sbjct: 159 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
Score = 50.4 bits (119), Expect = 3e-06
Identities = 33/95 (34%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
V+C D+ G TPL AA+ ++ +LLLRH A VN + G TALM AA +G +
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS-GKTALMMAAENGQAGAVDI 865
Query: 99 ML-EAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++ A A+ V + T +A G C +I
Sbjct: 866 LVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 1/109 (0%)
Query: 26 QEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALM 85
+EA +L + VN D+N TPL AA + ++++ + VN G TAL
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALH 120
Query: 86 FAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
AAL+G+ ++ ++L GA + + R A AA++G D V ++ N
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Score = 47.4 bits (111), Expect = 3e-05
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 15/153 (9%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
++C+D++G TPL AA G + L GAD H L AAL+ + D
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADT-AKCGIHSMFPLHLAALNAHSDCCRK 365
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPP 158
+L +G E D + GRT AA G +C+ ++ + D++ K DK +
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQS----SGADFHKK----DKCGRT-- 415
Query: 159 KLAGPLHKIITTTNLHPVKIVMLVNENPLLTEE 191
PLH + H ++ ++ N T++
Sbjct: 416 ----PLHYAAANCHFHCIETLVTTGANVNETDD 444
Score = 42.4 bits (98), Expect = 9e-04
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 26 QEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVN--CHQHEHGYTA 83
+E +L + V + C D G TPL +AA +G LL+ C + GYT
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Query: 84 LMFAALSGNKDITWVMLE 101
L +A +GN++ V+LE
Sbjct: 751 LHWACYNGNENCIEVLLE 768
Score = 40.8 bits (94), Expect = 0.002
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 3/94 (3%)
Query: 43 DENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTA--LMFAALSGNKDITWVML 100
D+ G + +AA G +LLL + + + G T L AA +G+ V+L
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562
Query: 101 EAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
++ + D+ + GRTA +AAF G +CV + N
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN 596
Score = 38.5 bits (88), Expect = 0.012
Identities = 35/142 (24%), Positives = 53/142 (37%), Gaps = 36/142 (25%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGAD--------------- 71
+A +L V ++ DE G T L AA+KG + + L+ GA
Sbjct: 556 QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
Query: 72 --VNCH-------------------QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVN 110
+N H + G T LM A G+ D ++LE A D V+
Sbjct: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVD 675
Query: 111 SVGRTAAQMAAFVGQHDCVTII 132
+G TA G +CV ++
Sbjct: 676 ILGCTALHRGIMTGHEECVQML 697
Score = 38.1 bits (87), Expect = 0.016
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L K VN LD TPL AA+ G ++ +LL+ GA VN + T L A S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNA-KDNMWLTPLHRAVAS 59
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+++ V+++ A+ + + +T +AA C +I
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 37.7 bits (86), Expect = 0.021
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 1/103 (0%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L S ++ D+ G T L AA G ++ KLL GAD + + + G T L +AA +
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH-KKDKCGRTPLHYAAANC 424
Query: 92 NKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
+ ++ GA + + GRTA AA TI+ N
Sbjct: 425 HFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Score = 37.4 bits (85), Expect = 0.027
Identities = 29/86 (33%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
V+ D G TPLM A G +D LLL A+V+ G TAL ++G+++ +
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT-VDILGCTALHRGIMTGHEECVQM 696
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVG 124
+LE +S GRT AA G
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYAAARG 722
Score = 36.6 bits (83), Expect = 0.047
Identities = 26/95 (27%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L + V ++ ++ G T L A Y G+ + L+ +GA+VN + +G+T L FAA S
Sbjct: 200 LLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAAAST 258
Query: 92 NKDITW-VMLEAGAETDVVNSVGRTAAQMAAFVGQ 125
+ + +++ GA+ ++ + G++ M A G+
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Score = 36.6 bits (83), Expect = 0.047
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 5/93 (5%)
Query: 45 NGMTPLMHAAYKGKLDMCKLLLRHGAD---VNCHQHEHGYTALMFAALSGNKDITWVMLE 101
N TPL H A C LL D V+C + G T L AA + + + ++L
Sbjct: 778 NPFTPL-HCAIINDHGNCASLLLGAIDSSIVSCRD-DKGRTPLRAAAFADHVECLQLLLR 835
Query: 102 AGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
A + V++ G+TA MAA GQ V I+ N
Sbjct: 836 HSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Score = 30.8 bits (68), Expect = 2.6
Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 1/74 (1%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L G E LL S + D+ G TPL +AA + L+ GA+VN
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN-ET 442
Query: 77 HEHGYTALMFAALS 90
+ G TAL +AA S
Sbjct: 443 DDWGRTALHYAAAS 456
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 67.4 bits (163), Expect = 2e-11
Identities = 41/105 (39%), Positives = 57/105 (54%), Gaps = 2/105 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL +K +N D+ PL AA+ G L++ KLL+ GAD+ C + GY L
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK-GYGLLHT 212
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTI 131
AA SG ++ +L GAE D N+ G TA +A ++GQ D V I
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ-DAVAI 256
Score = 53.1 bits (126), Expect = 5e-07
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 3/109 (2%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
EA L+ V ++ D G T L A +G + ++L HGA + + +T L
Sbjct: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHA 658
Query: 87 AALSGNKDITWVMLEAGAE---TDVVNSVGRTAAQMAAFVGQHDCVTII 132
AA SG+ D +++++G TDV+++ G+T +A G DCV ++
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 52.4 bits (124), Expect = 8e-07
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 2/87 (2%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHG--ADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
TPL AA G D LL+ G AD+ +G T LM A ++G+ D ++LE G+
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
D + GRTA A G DC+ +
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAAL 740
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/110 (32%), Positives = 59/110 (53%), Gaps = 2/110 (1%)
Query: 12 EEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGAD 71
++ L++ I V+E +LLS K +N LD+ TPL AAY G + + +LLL GA+
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKE-NINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66
Query: 72 VNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
VN + T L AA S N+ + ++L A+ + + + +T +AA
Sbjct: 67 VNA-KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA 115
Score = 49.7 bits (117), Expect = 5e-06
Identities = 34/95 (35%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
VN D G TPL AA+ + ++LL+H A+VN H G TALM AA +G
Sbjct: 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-GRTALMTAAENGQTAAVEF 909
Query: 99 MLEAG-AETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+L G A+ V++ TA +A G C +I
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944
Score = 47.8 bits (112), Expect = 2e-05
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMC-KLLLRHGADVNCHQHEHGYTALMFAALS 90
L + VN ++ G TPL AA +C +LL+ +GADVN +Q + G + L AA+
Sbjct: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVN-YQSKEGKSPLHMAAIH 316
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
G + ++++ G+E D + G T +AA G
Sbjct: 317 GRFTRSQILIQNGSEIDCADKFGNTPLHVAARYG 350
Score = 45.1 bits (105), Expect = 1e-04
Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL ++ + C D G L AA G++++ K LLR GA+++ + G TAL A
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID-EPNAFGNTALHIACYL 249
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
G + ++ AGA + N G T +AA
Sbjct: 250 GQDAVAIELVNAGANVNQPNDKGFTPLHVAA 280
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 1/98 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + VN + G +PL AA G+ ++L+++G++++C + G T L AA
Sbjct: 291 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC-ADKFGNTPLHVAARY 349
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDC 128
G++ + ++ GA+T +A G DC
Sbjct: 350 GHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Score = 37.0 bits (84), Expect = 0.036
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 6/109 (5%)
Query: 18 EVIGKGTVQEAGTLLSSKNVR-----VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADV 72
+++ G + + LS+++V +N D G T L AA G ++ LLL GAD+
Sbjct: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADL 449
Query: 73 NCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
+ + G T L +AA +G+ ++ AGA + + G + AA
Sbjct: 450 R-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497
Score = 36.6 bits (83), Expect = 0.047
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 42 LDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
+D G TPLM A G +D LLL G+ + G TAL A++G +D +L+
Sbjct: 684 MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA-ADLRGRTALHRGAVTGCEDCLAALLD 742
Query: 102 AGAETDVVNSVGRTAAQMAAFVG 124
A + GRT +A+ G
Sbjct: 743 HDAFVLCRDFKGRTPIHLASACG 765
Score = 34.7 bits (78), Expect = 0.18
Identities = 33/134 (24%), Positives = 47/134 (35%), Gaps = 32/134 (23%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQH------------- 77
LL VN D +TPL AA + LLL H ADVN
Sbjct: 59 LLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118
Query: 78 -------------------EHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQ 118
G +AL A SG+ + ++L GA +V + R
Sbjct: 119 ATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLH 178
Query: 119 MAAFVGQHDCVTII 132
AAF+G + + ++
Sbjct: 179 WAAFLGHLEVLKLL 192
Score = 34.7 bits (78), Expect = 0.18
Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 42 LDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
+D +G +P+ A+Y G D +LLL H + + +T L A ++ N+D T ML
Sbjct: 787 VDYSGYSPMHWASYTGHEDCLELLLEHSP--FSYLEGNPFTPLHCAVIN-NQDSTTEMLL 843
Query: 102 AGAETDVVNS---VGRTAAQMAAF 122
+VNS GRT AAF
Sbjct: 844 GALGAKIVNSRDAKGRTPLHAAAF 867
Score = 34.3 bits (77), Expect = 0.23
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 18/104 (17%)
Query: 47 MTPLMHAAYKGKLDMCKLLLRHG---ADVNCHQHEH--------------GYTALMFAAL 89
M PL A G D C+ LL G + V+ +EH G T L AA
Sbjct: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAAS 432
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDC-VTII 132
GN + ++L +GA+ + GRT AA G + C VT++
Sbjct: 433 GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
Score = 32.0 bits (71), Expect = 1.1
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 5/93 (5%)
Query: 43 DENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHG---YTALMFAALSGNKDITWVM 99
D G T + +AA G +LLL NC + + L AA +G+ + +
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLE--MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
Query: 100 LEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
E DV + GRTA +A G +CV ++
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 67.4 bits (163), Expect = 2e-11
Identities = 39/100 (39%), Positives = 59/100 (59%), Gaps = 1/100 (1%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
+LL + V+ D++GMTPL+ AAY+G +D+ LLL GADV+ H +G T L+ AA
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAAS 790
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G+ + +L GA D ++S GRT +A+ G + V
Sbjct: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVV 830
Score = 60.8 bits (146), Expect = 2e-09
Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 1/105 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L + + VN D + L AA++G + + +LL+ HGA V+ H G TAL AA
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD-HTCNQGATALCIAAQE 1055
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNF 135
G+ D+ V+LE GA+ + + GRTA ++AA G + ++ +
Sbjct: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Score = 60.5 bits (145), Expect = 3e-09
Identities = 46/160 (28%), Positives = 67/160 (41%), Gaps = 34/160 (21%)
Query: 4 IKKGELTQEEKELLEVIGKGTVQEAGTL--LSSKNVRVNCLDENGMTPLMHAAYKGKLDM 61
+K G E + I + ++ ++ L VN D NG T L +AAY G LD+
Sbjct: 501 VKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDV 560
Query: 62 CKLLLRHGAD-----------------------VNC---------HQHEHGYTALMFAAL 89
LL+ GAD VNC H + G+TAL AA
Sbjct: 561 VNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAW 620
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G+ ++ +L AG + D ++ RTA + AA+ G D V
Sbjct: 621 GGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
Score = 58.9 bits (141), Expect = 9e-09
Identities = 38/95 (40%), Positives = 56/95 (58%), Gaps = 1/95 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E + L V+V+C D + T L AA+ G D+ LL+HGA+VN +E G TAL+
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE-GRTALIA 683
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
AA G+++I +L+ GAE + + GRTA +AA
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/91 (36%), Positives = 51/91 (56%), Gaps = 1/91 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
+N D++G T L AA+ G ++ LL G V+C + TAL AA G++DI
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD-SRTALRAAAWGGHEDIVLN 662
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
+L+ GAE + ++ GRTA AA++G + V
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYMGHREIV 693
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/106 (33%), Positives = 52/106 (49%), Gaps = 6/106 (5%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAY-----KGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
L VN D +G T L AA KG + LL+ GA+V+ H + G T L+
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLV 754
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
AA G+ D+ ++LE GA+ D ++ GRT AA +G V +
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 50.1 bits (118), Expect = 4e-06
Identities = 34/111 (30%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
+G V+ TLL + + N D+ G TPL AA++G +C+ L+ GA N ++ G
Sbjct: 824 QGNVEVVRTLLD-RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND-GR 881
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+ A+ G+ D ++LE + D GR A ++AA G D V ++
Sbjct: 882 IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 49.7 bits (117), Expect = 5e-06
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 45 NGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGA 104
+G L AA +G D+ +LL HGADVNC + G L AL + LE GA
Sbjct: 912 DGRNALRVAALEGHRDIVELLFSHGADVNCKDAD-GRPTLYILALENQLTMAEYFLENGA 970
Query: 105 ETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+ ++ GRTA ++ + G + V ++
Sbjct: 971 NVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL S VNC D +G L A + +L M + L +GA+V E G TAL +
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAE-GRTALHVSCWQ 989
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+ ++ V++ A+ + ++ R+A Q AA+ G V ++
Sbjct: 990 GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Score = 42.4 bits (98), Expect = 9e-04
Identities = 33/124 (26%), Positives = 62/124 (50%), Gaps = 15/124 (12%)
Query: 9 LTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRH 68
L +E+E+L+++ K AG ++S++ R +C+ + + D + LL +
Sbjct: 489 LIPKEQEVLQLLVK-----AGAHVNSEDDRTSCIVRQALE---------REDSIRTLLDN 534
Query: 69 GADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDC 128
GA VN +G T L AA SG+ D+ +++ GA+ ++ ++ G T +AA G
Sbjct: 535 GASVN-QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKV 593
Query: 129 VTII 132
V +
Sbjct: 594 VNCL 597
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 66.2 bits (160), Expect = 6e-11
Identities = 39/110 (35%), Positives = 59/110 (53%), Gaps = 1/110 (0%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
KG + LLS+ + VNC D+ G TP++ A +D+ KLLL G+D+N +E
Sbjct: 849 KGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEEN- 907
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTI 131
L +AA SG DI ++L A + VN G + +AA ++DCV +
Sbjct: 908 ICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVL 957
Score = 44.3 bits (103), Expect = 2e-04
Identities = 27/87 (31%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVN-CHQHEHGYTALMFAALSGNKDITWVMLEA 102
+N +PL AA G +D+C +L++ GA+++ C + + T LM AA + + + +++A
Sbjct: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR--TPLMEAAENNHLEAVKYLIKA 828
Query: 103 GAETDVVNSVGRTAAQMAAFVGQHDCV 129
GA D ++ G T +AA G ++ V
Sbjct: 829 GALVDPKDAEGSTCLHLAAKKGHYEVV 855
Score = 35.4 bits (80), Expect = 0.10
Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 50 LMHAAYKGKLDMCKLLLRHGADVNCH-QHEHGYTALMFAALSGNKDITWVMLEAGAETDV 108
L +A +G+L L+L G D N +H++ + L AA +G+ DI ++++AGA D
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 109 VNSVGRTAAQMAA 121
+ RT AA
Sbjct: 802 CSEDQRTPLMEAA 814
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 66.2 bits (160), Expect = 6e-11
Identities = 42/108 (38%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
+G + LL+S V V+C D +G T LM AAY G +D + L+ GAD+N Q E G
Sbjct: 22 RGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL-QRESGT 80
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
TAL FAA G+ D+ + GA T+ G TA A+ G V
Sbjct: 81 TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
Score = 54.7 bits (130), Expect = 2e-07
Identities = 57/198 (28%), Positives = 83/198 (41%), Gaps = 24/198 (12%)
Query: 16 LLEVIGKGTVQEAGTLLS-SKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNC 74
LL G +Q TLL N+ D G T L AA G LD+ +LLL GA VN
Sbjct: 116 LLAASQYGHMQVVETLLKHGANIHDQLYD--GATALFLAAQGGYLDVIRLLLASGAKVN- 172
Query: 75 HQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
+ G L A+ G+ ++ VML GA+ D + G TA AA G +D + +
Sbjct: 173 QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK 232
Query: 135 FFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVMLVNENPLLTEE--- 191
F P G+ K LH + + N+ V +++ +P L +
Sbjct: 233 FSP---------TLGILKNG------TSALHAAVLSGNIKTVALLLEAGADPSLRNKANE 277
Query: 192 --AALNKCYRVMDLICEK 207
A L K R++ L+ K
Sbjct: 278 LPAELTKNERILRLLRSK 295
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/93 (37%), Positives = 49/93 (52%), Gaps = 6/93 (6%)
Query: 48 TPLMHAAY----KGKLDMCKLLLRHG-ADVNCHQHEHGYTALMFAALSGNKDITWVMLEA 102
TPL +AA+ +G L + KLLL G DV+C HG T LM AA +G+ D ++
Sbjct: 10 TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRD-SHGTTLLMVAAYAGHIDCVRELVLQ 68
Query: 103 GAETDVVNSVGRTAAQMAAFVGQHDCVTIINNF 135
GA+ ++ G TA AA G +D V + F
Sbjct: 69 GADINLQRESGTTALFFAAQQGHNDVVRFLFGF 101
Score = 43.9 bits (102), Expect = 3e-04
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
++G T L+ A+ G + + + LL+HGA+++ ++ G TAL AA G D+ ++L +G
Sbjct: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYD-GATALFLAAQGGYLDVIRLLLASG 168
Query: 104 AETDVVNSVGRTAAQMAAFVGQHDCVTII 132
A+ + G +A+ +G + V ++
Sbjct: 169 AKVNQPRQDGTAPLWIASQMGHSEVVRVM 197
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 64.3 bits (155), Expect = 2e-10
Identities = 38/103 (36%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL S+N N MTP+M+AA G + LL+ HGA+VN Q E+GYTAL +AA
Sbjct: 134 LLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT-QDENGYTALTWAARQ 192
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIIN 133
G+K+I +LE GA + G+ +++A H+ +++
Sbjct: 193 GHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLS 235
Score = 30.0 bits (66), Expect = 4.4
Identities = 16/48 (33%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 57 GKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGA 104
G + + + LL G V+ + ++G+T LM+AA N ++ V+L+ GA
Sbjct: 57 GDVSLVQELLDSGISVDSN-FQYGWTPLMYAASVANAELVRVLLDRGA 103
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 63.5 bits (153), Expect = 4e-10
Identities = 40/121 (33%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Query: 10 TQEEK---ELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLL 66
T EEK ++ + G Q + VN ++ +G TPLM AA G+L + +LL+
Sbjct: 287 TDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLV 346
Query: 67 RHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
ADV+ HG+TALM A GNK+I +L GA+ + G TA + +
Sbjct: 347 ERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDP 406
Query: 127 D 127
D
Sbjct: 407 D 407
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/115 (34%), Positives = 60/115 (52%), Gaps = 4/115 (3%)
Query: 18 EVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQH 77
EV G G AG + V V+C DE G T L AA G + + LLR GA VN H
Sbjct: 53 EVAGPGAAA-AGAV--GAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNH 109
Query: 78 EHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+G++ALM AA G+ + ++L+ GA+ + N +G + +A+ G V ++
Sbjct: 110 -YGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLL 163
Score = 46.6 bits (109), Expect = 5e-05
Identities = 29/76 (38%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L + VN + G + LM AA G + + LLL HGADVN Q+ G + L A+ G
Sbjct: 97 LLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGG 155
Query: 92 NKDITWVMLEAGAETD 107
+ + ++LEAGA D
Sbjct: 156 HLGVVKLLLEAGAFVD 171
Score = 43.9 bits (102), Expect = 3e-04
Identities = 27/87 (31%), Positives = 45/87 (51%)
Query: 47 MTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAET 106
+T LM A G + +LL+ GAD N G++ LM AAL+G + ++E GA
Sbjct: 192 ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
Query: 107 DVVNSVGRTAAQMAAFVGQHDCVTIIN 133
D ++ + +TA ++A D V ++
Sbjct: 252 DHLSVLEKTAFEVALDCKHRDLVDYLD 278
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 62.4 bits (150), Expect = 8e-10
Identities = 41/114 (35%), Positives = 59/114 (51%), Gaps = 2/114 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + VN D+ G TPLM AA +G L LL GA + E G TAL +A L
Sbjct: 1085 LLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKE-GLTALSWACLK 1143
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVT-IINNFFPRERLDY 143
G+ + +++ GA TD + GRT +AAF G + V ++++ E +DY
Sbjct: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDY 1197
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 2/91 (2%)
Query: 35 KNVRVNCLDEN-GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNK 93
+ ++N D G T L AA +GKL++C+LLL GA V + G L G+
Sbjct: 1022 ERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAV-AQPNRRGAVPLFSTVRQGHW 1080
Query: 94 DITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
I ++L GA+ ++ + GRT MAA G
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEG 1111
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/75 (33%), Positives = 41/75 (54%), Gaps = 1/75 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL V+ E+G+TPL +AA G L + LL + A V+ H ++G AL+
Sbjct: 899 EMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVH 957
Query: 87 AALSGNKDITWVMLE 101
AAL G+ ++ +++
Sbjct: 958 AALRGHLEVVKFLIQ 972
Score = 37.4 bits (85), Expect = 0.027
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 16/111 (14%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLR-----HGADVNCHQHEHG-YTAL 84
LL K +V+ LD+NG L+HAA +G L++ K L++ G + H AL
Sbjct: 936 LLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQAL 995
Query: 85 MFAALSGNKDITWVML------EAGAETDVVNSV----GRTAAQMAAFVGQ 125
+ AA G +I +L E E +NS G TA AA G+
Sbjct: 996 IAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 62.4 bits (150), Expect = 8e-10
Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL S +VN D+NG TPL AA +G + +LL+ + A++N H + G T L A +
Sbjct: 762 LLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANIN-HAADGGQTPLYLACKN 820
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
GNK+ ++LEAG V + G T A G D + ++
Sbjct: 821 GNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL 862
Score = 47.0 bits (110), Expect = 3e-05
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 15/165 (9%)
Query: 16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCH 75
L + +G V LL+ + + +N E+G + L AA G D +LLL A VN
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA- 772
Query: 76 QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNF 135
++G+T L AA G+ + +++ A + G+T +A G +C+ ++
Sbjct: 773 ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL--- 829
Query: 136 FPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVM 180
G ++ K P+H + T N+ +K++M
Sbjct: 830 ----------LEAGTNRSVKTTDGWT-PVHAAVDTGNVDSLKLLM 863
Score = 33.1 bits (74), Expect = 0.52
Identities = 29/109 (26%), Positives = 46/109 (42%), Gaps = 10/109 (9%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
EAGT S K +G TP+ A G +D KLL+ H + + +
Sbjct: 831 EAGTNRSVKTT-------DGWTPVHAAVDTGNVDSLKLLMYHRIPAHGNSFNEEESESSV 883
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGR---TAAQMAAFVGQHDCVTII 132
L G ++ + + D++N R TAA +AA G +C+ I+
Sbjct: 884 FDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKNCLEIL 932
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 61.6 bits (148), Expect = 1e-09
Identities = 38/103 (36%), Positives = 58/103 (56%), Gaps = 2/103 (1%)
Query: 19 VIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHE 78
++ +G+V++ LL+ + V V+C +G TPL+ AA + D+C LLL HGAD N E
Sbjct: 369 LVAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN-RVDE 426
Query: 79 HGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
G+ L FAA +G+ ++L+ GA D G T +AA
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469
Score = 57.8 bits (138), Expect = 2e-08
Identities = 38/113 (33%), Positives = 62/113 (54%), Gaps = 2/113 (1%)
Query: 20 IGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEH 79
+ +G V+ LL S V + LD++G PL AA +GK +CK+LLR+GA + H+
Sbjct: 535 VERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ- 592
Query: 80 GYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+T L AA G+ +I ++ E+ A + +V T +AA G+ V+ +
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/120 (30%), Positives = 60/120 (50%), Gaps = 6/120 (5%)
Query: 7 GELTQE-EKELLEVIGKGTVQEAGTLLSSKNVRVN----CLDENGMTPLMHAAYKGKLDM 61
GE+ ++ +EL++ ++ A L KN+ C+ EN +TPL +G ++
Sbjct: 318 GEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQ 377
Query: 62 CKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
+LLL H DV+C Q GYT L+ AA D+ ++L GA+ + V+ G AA
Sbjct: 378 VRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAA 436
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/104 (29%), Positives = 55/104 (52%), Gaps = 1/104 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + N +DE+G PL AA G +LLL HGA V+ + E G+T L AA +
Sbjct: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQN 471
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
+++ +++ A+ ++ + G+T +AA+ G V ++ +
Sbjct: 472 NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/81 (37%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 40 NCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVM 99
N +++G TPL A + LL H A+V+ +++ G+T AAL GN I V+
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA-RNKVGWTPAHLAALKGNTAILKVL 711
Query: 100 LEAGAETDVVNSVGRTAAQMA 120
+EAGA+ DV + V T Q+A
Sbjct: 712 VEAGAQLDVQDGVSCTPLQLA 732
Score = 42.0 bits (97), Expect = 0.001
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 1/110 (0%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L + + + LL S+ N + G TPL AAY G + + KLL GA+++ Q
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA-Q 523
Query: 77 HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
+ T L A G +L++GA D ++ G AA G++
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 61.6 bits (148), Expect = 1e-09
Identities = 36/110 (32%), Positives = 56/110 (50%), Gaps = 8/110 (7%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL S+ +N D+ + AAY G +++ KLL+ HGA+V C + + YT L AA S
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC-KDKKSYTPLHAAASS 216
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH-------DCVTIIN 133
G + +L+ G + + N+ G T +A + GQ DC I+N
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 2/112 (1%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G + T++ S V ++C D+NG TPL AA G + L+ GAD + HG
Sbjct: 317 GRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITSGADT-AKRGIHGMF 374
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
L AALSG D +L +G + D + GRT AA G +C+ ++ N
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 2/84 (2%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCH--QHEHGYTALMFAALSGNKDITWVMLEAGAE 105
TP+ AA G + +LL+ + N Q +G T LM + L+G+ D + +L GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCV 129
D + GRTA A G +CV
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECV 702
Score = 46.6 bits (109), Expect = 5e-05
Identities = 30/86 (34%), Positives = 48/86 (55%), Gaps = 1/86 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
V+ D NG TPLM + G D LL GA+V+ + + G TAL A++G+++
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA-KDKWGRTALHRGAVTGHEECVDA 704
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVG 124
+L+ GA+ + +S GRT ++A G
Sbjct: 705 LLQHGAKCLLRDSRGRTPIHLSAACG 730
Score = 45.8 bits (107), Expect = 8e-05
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL S V C D+ TPL AA G + + K LL G D+N + +G T L
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
A +G + +++ GA + N G T AA
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA 280
Score = 45.4 bits (106), Expect = 1e-04
Identities = 32/107 (29%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Query: 26 QEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALM 85
+EA +L + VN D+N TPL AA + + L+ ++VN G TAL
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA-GRTALH 145
Query: 86 FAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
AA SG+ ++ ++L GA + + R A AA++G + V ++
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/102 (30%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL RVN D +TPL A + ++LL+H ADVN + ++ T L AA +
Sbjct: 59 LLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA-RDKNWQTPLHIAAAN 117
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++ + +V + GRTA AAF G + V ++
Sbjct: 118 KAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159
Score = 43.9 bits (102), Expect = 3e-04
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKD-ITW 97
VN D G TPL AA+ ++ +LLL H A VN G T LM AA +G + +
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN-SVDSTGKTPLMMAAENGQTNTVEM 874
Query: 98 VMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++ A AE + ++ TA +A G +I
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
Score = 43.5 bits (101), Expect = 4e-04
Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 45 NGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGA 104
+GM PL AA G D C+ LL G D++ + G T L AA GN + ++L GA
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD-DFGRTCLHAAAAGGNLECLNLLLNTGA 429
Query: 105 ETDVVNSVGRTAAQMAAFVGQHDCV 129
+ + + GR+ AA + C+
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCL 454
Score = 43.1 bits (100), Expect = 5e-04
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL S N +VN +D G TPLM AA G+ + ++L+ + Q TAL A
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G++ ++LE + +++N+ A Q V + +T++
Sbjct: 901 GHETSALLILEKITDRNLINAT-NAALQTPLHVAARNGLTMV 941
Score = 42.4 bits (98), Expect = 9e-04
Identities = 31/87 (35%), Positives = 45/87 (51%), Gaps = 2/87 (2%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMC-KLLLRHGADVNCHQHEHGYTALMFAALSGNKDITW 97
VN +E G TPL AA +C +LL+ +GADVN + + G T L AL G +
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM-KSKDGKTPLHMTALHGRFSRSQ 323
Query: 98 VMLEAGAETDVVNSVGRTAAQMAAFVG 124
++++GA D + G T +AA G
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYG 350
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 2/111 (1%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGA 70
+++ L++ I G E L+ K VN D TPL AAY G ++ +LL+ GA
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKKE-DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 71 DVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
VN + T L A S +++ V+L+ A+ + + +T +AA
Sbjct: 66 RVNA-KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAA 115
Score = 38.1 bits (87), Expect = 0.016
Identities = 38/149 (25%), Positives = 58/149 (38%), Gaps = 47/149 (31%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMC-KLLLRHGADVNCHQHEHGYTALMFAALS 90
L VN LDE G TPL +AA C + LLR+ A+ + GY A+ ++A
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQ-GYNAVHYSAAY 515
Query: 91 GNK------------DITW---------------------------------VMLEAGAE 105
G++ D+ V++++ +
Sbjct: 516 GHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD 575
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
DV NS GRT +AAF G +CV ++ N
Sbjct: 576 LDVRNSSGRTPLDLAAFKGHVECVDVLIN 604
Score = 37.7 bits (86), Expect = 0.021
Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L S ++ D+ G T L AA G L+ LLL GAD N + + G + L +AA +
Sbjct: 391 LLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANC 449
Query: 92 NKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
N + ++ +GA + ++ G T AA
Sbjct: 450 NYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Score = 33.1 bits (74), Expect = 0.52
Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 3/62 (4%)
Query: 43 DENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ---HEHGYTALMFAALSGNKDITWVM 99
D G TP+ +A G + + LL+ A ++ + HGYTAL +A +G++ ++
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 100 LE 101
LE
Sbjct: 776 LE 777
Score = 31.6 bits (70), Expect = 1.5
Identities = 24/89 (26%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 45 NGMTPLMHAAYKGKLDMCKLLLRH-GADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
N +PL A ++L+ GA + G T L AA + + + ++L
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN 846
Query: 104 AETDVVNSVGRTAAQMAAFVGQHDCVTII 132
A+ + V+S G+T MAA GQ + V ++
Sbjct: 847 AQVNSVDSTGKTPLMMAAENGQTNTVEML 875
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G ++ LLS+ V VN D G TP++ AA +++ ++LL GADV +E
Sbjct: 728 GNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI- 786
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTI 131
L +A+ +G+ I V+L A + VN G T +AA HDCV +
Sbjct: 787 CLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/125 (27%), Positives = 60/125 (48%), Gaps = 3/125 (2%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG- 69
Q+ L+E + ++ A ++ V +E+G T L HAA G L+M LLL G
Sbjct: 683 QQRTPLMEAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQ 741
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
DVN Q G+T +++AA + ++ ++L GA+ + ++ A+F G
Sbjct: 742 VDVNA-QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIA 800
Query: 130 TIINN 134
++ N
Sbjct: 801 EVLLN 805
Score = 42.4 bits (98), Expect = 9e-04
Identities = 31/129 (24%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Query: 5 KKGELTQEEKELLEVIGKGTVQEAGT-LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCK 63
++ +L ++L + +G +Q+ LL + + ++ TPL AA KG +++C
Sbjct: 609 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 668
Query: 64 LLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFV 123
+LL+ GA++N + T LM A ++ + ++ M++ G G T AA +
Sbjct: 669 VLLQAGANINAVDKQQ-RTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKI 727
Query: 124 GQHDCVTII 132
G + V+++
Sbjct: 728 GNLEMVSLL 736
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G ++ LLS+ V VN D G TP++ AA +++ ++LL GADV +E
Sbjct: 762 GNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI- 820
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTI 131
L +A+ +G+ I V+L A + VN G T +AA HDCV +
Sbjct: 821 CLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/125 (27%), Positives = 60/125 (48%), Gaps = 3/125 (2%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG- 69
Q+ L+E + ++ A ++ V +E+G T L HAA G L+M LLL G
Sbjct: 717 QQRTPLMEAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQ 775
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
DVN Q G+T +++AA + ++ ++L GA+ + ++ A+F G
Sbjct: 776 VDVNA-QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIA 834
Query: 130 TIINN 134
++ N
Sbjct: 835 EVLLN 839
Score = 42.4 bits (98), Expect = 9e-04
Identities = 31/129 (24%), Positives = 64/129 (49%), Gaps = 2/129 (1%)
Query: 5 KKGELTQEEKELLEVIGKGTVQEAGT-LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCK 63
++ +L ++L + +G +Q+ LL + + ++ TPL AA KG +++C
Sbjct: 643 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 702
Query: 64 LLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFV 123
+LL+ GA++N + T LM A ++ + ++ M++ G G T AA +
Sbjct: 703 VLLQAGANINAVDKQQ-RTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKI 761
Query: 124 GQHDCVTII 132
G + V+++
Sbjct: 762 GNLEMVSLL 770
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/102 (32%), Positives = 54/102 (52%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L ++ + +ENG TPLM AA G +++ ++LL HGA +N H +E +AL A
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+ D+ +LEAGA+ + TA A G + ++
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/126 (35%), Positives = 60/126 (47%), Gaps = 2/126 (1%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENG-MTPLMHAAYKGKLDMCKLLL 66
E T+E + LL + E +L + + V G +TPLM A+ G LD+ KLLL
Sbjct: 233 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 67 RHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
H ADVN Q G TAL +A G DI V+L GA + N G T AA G
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 127 DCVTII 132
+ ++
Sbjct: 352 EVARVL 357
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/82 (32%), Positives = 44/82 (53%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL + + +++ G TPLM AA +G +M LLL GA++N E TAL
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 87 AALSGNKDITWVMLEAGAETDV 108
A G ++ +++AGA+ ++
Sbjct: 512 ACCGGFSEVADFLIKAGADIEL 533
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 16 LLEVIGKGTVQEAGTLL---SSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADV 72
L+E G V+ A LL + N N E+ +T A YKG LDM + LL GAD
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL---ACYKGHLDMVRFLLEAGADQ 398
Query: 73 NCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
H+ + +TALM A + G+ ++ ++L++GA+ ++ + +AA G + ++
Sbjct: 399 E-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 47.0 bits (110), Expect = 3e-05
Identities = 26/60 (43%), Positives = 39/60 (65%), Gaps = 1/60 (1%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETD 107
TPLM A+ +G L++ K LL GA+V+ G TAL +A +G+ D+ V+L+AGA+ D
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHA-TTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCH 75
L+E G V+ A LL S +VN ++ +PL AA G +++ LL+ GA++
Sbjct: 409 LMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE-E 466
Query: 76 QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
++ GYT LM AA G++++ ++L GA + + A A G
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/102 (32%), Positives = 54/102 (52%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L ++ + +ENG TPLM AA G +++ ++LL HGA +N H +E +AL A
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+ D+ +LEAGA+ + TA A G + ++
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 413
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/126 (35%), Positives = 60/126 (47%), Gaps = 2/126 (1%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENG-MTPLMHAAYKGKLDMCKLLL 66
E T+E + LL + E +L + + V G +TPLM A+ G LD+ KLLL
Sbjct: 222 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 281
Query: 67 RHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
H ADVN Q G TAL +A G DI V+L GA + N G T AA G
Sbjct: 282 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
Query: 127 DCVTII 132
+ ++
Sbjct: 341 EVARVL 346
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/82 (32%), Positives = 44/82 (53%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL + + +++ G TPLM AA +G +M LLL GA++N E TAL
Sbjct: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
Query: 87 AALSGNKDITWVMLEAGAETDV 108
A G ++ +++AGA+ ++
Sbjct: 501 ACCGGFSEVADFLIKAGADIEL 522
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 16 LLEVIGKGTVQEAGTLL---SSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADV 72
L+E G V+ A LL + N N E+ +T A YKG LDM + LL GAD
Sbjct: 331 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL---ACYKGHLDMVRFLLEAGADQ 387
Query: 73 NCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
H+ + +TALM A + G+ ++ ++L++GA+ ++ + +AA G + ++
Sbjct: 388 E-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446
Score = 47.0 bits (110), Expect = 3e-05
Identities = 26/60 (43%), Positives = 39/60 (65%), Gaps = 1/60 (1%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETD 107
TPLM A+ +G L++ K LL GA+V+ G TAL +A +G+ D+ V+L+AGA+ D
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHA-TTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCH 75
L+E G V+ A LL S +VN ++ +PL AA G +++ LL+ GA++
Sbjct: 398 LMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE-E 455
Query: 76 QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
++ GYT LM AA G++++ ++L GA + + A A G
Sbjct: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/102 (32%), Positives = 54/102 (52%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L ++ + +ENG TPLM AA G +++ ++LL HGA +N H +E +AL A
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+ D+ +LEAGA+ + TA A G + ++
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/126 (35%), Positives = 60/126 (47%), Gaps = 2/126 (1%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENG-MTPLMHAAYKGKLDMCKLLL 66
E T+E + LL + E +L + + V G +TPLM A+ G LD+ KLLL
Sbjct: 233 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 67 RHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
H ADVN Q G TAL +A G DI V+L GA + N G T AA G
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 127 DCVTII 132
+ ++
Sbjct: 352 EVARVL 357
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/81 (40%), Positives = 48/81 (59%), Gaps = 2/81 (2%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETD 107
TPLM A+ +G L++ K LL GA+V+ G TAL +A +G+ D+ V+L+AGA+ +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLE 595
Query: 108 VVNSVGRTAAQMAAFVGQHDC 128
+ GRT AA G H C
Sbjct: 596 HESEGGRTPLMKAARAG-HLC 615
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/82 (32%), Positives = 44/82 (53%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL + + +++ G TPLM AA +G +M LLL GA++N E TAL
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 87 AALSGNKDITWVMLEAGAETDV 108
A G ++ +++AGA+ ++
Sbjct: 512 ACCGGFSEVADFLIKAGADIEL 533
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/107 (33%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY-TALM 85
E +LL + V + G+TPLM AA G ++ ++LL GADVN TAL
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 86 FAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
AA G+ +++ GA DV N G T +A+ G D V ++
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 16 LLEVIGKGTVQEAGTLL---SSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADV 72
L+E G V+ A LL + N N E+ +T A YKG LDM + LL GAD
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL---ACYKGHLDMVRFLLEAGADQ 398
Query: 73 NCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
H+ + +TALM A + G+ ++ ++L++GA+ ++ + +AA G + ++
Sbjct: 399 E-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/112 (25%), Positives = 54/112 (48%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G +E ++L +++ ++ D+ G TPL+ AA G + + ++LL G D+ T
Sbjct: 1065 GGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
L A G +++ ++L GA + N T +AA G + + I+ N
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 46.6 bits (109), Expect = 5e-05
Identities = 33/118 (27%), Positives = 61/118 (51%), Gaps = 2/118 (1%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L + G QE LL ++ + + TPL AA G +++ K+LL GA++N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 77 -HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGR-TAAQMAAFVGQHDCVTII 132
+ G + LM AA++G+ ++L+ G++ + R TA +A F G+ + V+++
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCH 75
L+E G V+ A LL S +VN ++ +PL AA G +++ LL+ GA++
Sbjct: 409 LMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE-E 466
Query: 76 QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
++ GYT LM AA G++++ ++L GA + + A A G
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Score = 43.1 bits (100), Expect = 5e-04
Identities = 26/79 (32%), Positives = 38/79 (48%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G++PLM AA G + KLLL G+D+N + TAL A G ++ ++L+ A
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 106 TDVVNSVGRTAAQMAAFVG 124
+ G T AA G
Sbjct: 1250 VEHRAKTGLTPLMEAASGG 1268
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/92 (29%), Positives = 43/92 (46%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
E G TPLM AA G L + L+ GA+VN + +T + A G+ + ++L G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 104 AETDVVNSVGRTAAQMAAFVGQHDCVTIINNF 135
A+ G T AA G + V+ + ++
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 32.3 bits (72), Expect = 0.88
Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 1/71 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + ++ ++ G TPL A+ G D+ +LL++ GADV+ + T LM A
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK-ITPLMSAFRK 1368
Query: 91 GNKDITWVMLE 101
G+ + +++
Sbjct: 1369 GHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/102 (32%), Positives = 54/102 (52%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L ++ + +ENG TPLM AA G +++ ++LL HGA +N H +E +AL A
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G+ D+ +LEAGA+ + TA A G + ++
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/126 (35%), Positives = 60/126 (47%), Gaps = 2/126 (1%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENG-MTPLMHAAYKGKLDMCKLLL 66
E T+E + LL + E +L + + V G +TPLM A+ G LD+ KLLL
Sbjct: 233 EHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
Query: 67 RHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQH 126
H ADVN Q G TAL +A G DI V+L GA + N G T AA G
Sbjct: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 127 DCVTII 132
+ ++
Sbjct: 352 EVARVL 357
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/81 (40%), Positives = 48/81 (59%), Gaps = 2/81 (2%)
Query: 48 TPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETD 107
TPLM A+ +G L++ K LL GA+V+ G TAL +A +G+ D+ V+L+AGA+ +
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLE 595
Query: 108 VVNSVGRTAAQMAAFVGQHDC 128
+ GRT AA G H C
Sbjct: 596 HESEGGRTPLMKAARAG-HLC 615
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/82 (32%), Positives = 44/82 (53%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL + + +++ G TPLM AA +G +M LLL GA++N E TAL
Sbjct: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
Query: 87 AALSGNKDITWVMLEAGAETDV 108
A G ++ +++AGA+ ++
Sbjct: 512 ACCGGFSEVADFLIKAGADIEL 533
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/107 (33%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY-TALM 85
E +LL + V + G+TPLM AA G ++ ++LL GADVN TAL
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 86 FAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
AA G+ +++ GA DV N G T +A+ G D V ++
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 7/120 (5%)
Query: 16 LLEVIGKGTVQEAGTLL---SSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADV 72
L+E G V+ A LL + N N E+ +T A YKG LDM + LL GAD
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTL---ACYKGHLDMVRFLLEAGADQ 398
Query: 73 NCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
H+ + +TALM A + G+ ++ ++L++GA+ ++ + +AA G + ++
Sbjct: 399 E-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/112 (25%), Positives = 54/112 (48%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G +E ++L +++ ++ D+ G TPL+ AA G + + ++LL G D+ T
Sbjct: 1065 GGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINN 134
L A G +++ ++L GA + N T +AA G + + I+ N
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 46.6 bits (109), Expect = 5e-05
Identities = 33/118 (27%), Positives = 61/118 (51%), Gaps = 2/118 (1%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L + G QE LL ++ + + TPL AA G +++ K+LL GA++N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 77 -HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGR-TAAQMAAFVGQHDCVTII 132
+ G + LM AA++G+ ++L+ G++ + R TA +A F G+ + V+++
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 16 LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCH 75
L+E G V+ A LL S +VN ++ +PL AA G +++ LL+ GA++
Sbjct: 409 LMEACMDGHVEVARLLLDS-GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE-E 466
Query: 76 QHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVG 124
++ GYT LM AA G++++ ++L GA + + A A G
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
Score = 43.1 bits (100), Expect = 5e-04
Identities = 26/79 (32%), Positives = 38/79 (48%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G++PLM AA G + KLLL G+D+N + TAL A G ++ ++L+ A
Sbjct: 1190 GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
Query: 106 TDVVNSVGRTAAQMAAFVG 124
+ G T AA G
Sbjct: 1250 VEHRAKTGLTPLMEAASGG 1268
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/92 (29%), Positives = 43/92 (46%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
E G TPLM AA G L + L+ GA+VN + +T + A G+ + ++L G
Sbjct: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
Query: 104 AETDVVNSVGRTAAQMAAFVGQHDCVTIINNF 135
A+ G T AA G + V+ + ++
Sbjct: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Score = 32.3 bits (72), Expect = 0.88
Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 1/71 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + ++ ++ G TPL A+ G D+ +LL++ GADV+ + T LM A
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK-ITPLMSAFRK 1368
Query: 91 GNKDITWVMLE 101
G+ + +++
Sbjct: 1369 GHVKVVQYLVK 1379
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 60.8 bits (146), Expect = 2e-09
Identities = 35/89 (39%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L V D+ G+ PL +A G ++ LLLRHGAD N + YT L AA+ G
Sbjct: 77 LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDN-WNYTPLHEAAIKG 135
Query: 92 NKDITWVMLEAGAETDVVNSVGRTAAQMA 120
D+ V+L+ GAE + N+ GRTA +A
Sbjct: 136 KIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 48.9 bits (115), Expect = 9e-06
Identities = 36/125 (28%), Positives = 56/125 (44%), Gaps = 4/125 (3%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E L VN D+ G+ PL +AA G +D+ LL+++ A VN + +T L
Sbjct: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATD-KWAFTPLHE 751
Query: 87 AALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFFPRERLDYYTK 146
AA G + ++L GA+ + N G+T + V D ++ P L K
Sbjct: 752 AAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL---VSADDVSALLTAAMPPSALPSCYK 808
Query: 147 PQGLD 151
PQ L+
Sbjct: 809 PQVLN 813
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 5/120 (4%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGM--TPLMHAAYKGKLDMCKLL 65
+L + + LL+ KG + L S NV NC D G TPL AA L++ + L
Sbjct: 641 DLLRGDAALLDAAKKGCLARVKKLSSPDNV--NCRDTQGRHSTPLHLAAGYNNLEVAEYL 698
Query: 66 LRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQ 125
L+HGADVN Q + G L AA G+ D+ ++++ A + + T AA G+
Sbjct: 699 LQHGADVNA-QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 6 KGELTQEEK--ELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCK 63
K LT E K ELLE G ++ LL+ NV + D TPL AA ++ + +
Sbjct: 169 KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQ 228
Query: 64 LLLRHGADVNCHQHEHGYTALMFAALS-GNKDITWVMLEAGA 104
LLL+HGADV H + G + A S G+ ++T ++++ GA
Sbjct: 229 LLLQHGADV--HAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLR 67
E T+E L V + + ++ +VN LD G T L AAY G L C+LLL
Sbjct: 395 EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
Query: 68 HGADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
+G D N + G+TAL GN+++ ++ E
Sbjct: 455 YGCDPNIISLQ-GFTALQM----GNENVQQLLQE 483
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/123 (24%), Positives = 63/123 (51%), Gaps = 1/123 (0%)
Query: 10 TQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG 69
++ +++LLE G V+ L + ++V ++ TPL AA ++ + + LL+HG
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
ADV+ + + G L A G+ ++ ++++ GA +V + T AA G+++
Sbjct: 550 ADVHA-KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608
Query: 130 TII 132
++
Sbjct: 609 KLL 611
Score = 43.1 bits (100), Expect = 5e-04
Identities = 23/45 (51%), Positives = 26/45 (57%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGAD 71
E LL VN D TPL AA KGK ++CKLLL+HGAD
Sbjct: 573 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617
Score = 41.2 bits (95), Expect = 0.002
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 1/77 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
V+ D+ G+ PL +A G ++ +LL++HGA VN +T L AA G +I +
Sbjct: 552 VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK-FTPLHEAAAKGKYEICKL 610
Query: 99 MLEAGAETDVVNSVGRT 115
+L+ GA+ N G T
Sbjct: 611 LLQHGADPTKKNRDGNT 627
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMF 86
E LL N D TPL AA KGK+D+C +LL+HGA+ ++ G TAL
Sbjct: 105 EVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTI-RNTDGRTALDL 163
Query: 87 AALSGNKDIT 96
A S +T
Sbjct: 164 ADPSAKAVLT 173
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL K +N + +TPL A+ K D+ +++++H A VN + G T+L AA
Sbjct: 385 LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDN-LGQTSLHRAAYC 443
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQM 119
G+ ++L G + ++++ G TA QM
Sbjct: 444 GHLQTCRLLLSYGCDPNIISLQGFTALQM 472
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 27 EAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGAD---VNCH 75
E LL VN +D TPL AA K ++++C LLL +GAD +NCH
Sbjct: 258 EVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCH 309
Score = 38.9 bits (89), Expect = 0.009
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 1/90 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL V+ D+ + PL +A G ++ +LL++HGA VN +T L AA
Sbjct: 229 LLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA-MDLWQFTPLHEAASK 287
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
++ ++L GA+ ++N ++A +A
Sbjct: 288 NRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 38.9 bits (89), Expect = 0.009
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 1/70 (1%)
Query: 55 YKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGR 114
Y + +C+LLLR GA++N E T L A+ + D+ V+++ A+ + ++++G+
Sbjct: 376 YPKRKQICELLLRKGANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ 434
Query: 115 TAAQMAAFVG 124
T+ AA+ G
Sbjct: 435 TSLHRAAYCG 444
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 60.5 bits (145), Expect = 3e-09
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 1/99 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + VN D+ G TPLM AA +G L + LL GA ++ E G +AL +A L
Sbjct: 1122 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKE-GLSALSWACLK 1180
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G++ + ++E GA D + GRT +AAF G + V
Sbjct: 1181 GHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1219
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/87 (36%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G T L AA +GKL++C+LLL HGA V+ + G L AA G+ I ++LE G +
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRGVPPLFCAARQGHWQIVRLLLERGCD 1129
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
++ + GRT +AA G V +
Sbjct: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFL 1156
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/75 (36%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 26 QEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALM 85
+E TLL ++ ENGMT L +AA G + + LL + G V+ H + G AL+
Sbjct: 940 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALV 998
Query: 86 FAALSGNKDITWVML 100
+AL G+ DI +L
Sbjct: 999 HSALRGHGDILQYLL 1013
Score = 35.0 bits (79), Expect = 0.14
Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L NV N L ++ G ++ LLL GA ++ E+G TAL +AA +
Sbjct: 912 ILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLD-GTSENGMTALCYAAAA 970
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHD 127
G+ + ++ + G D ++ G+ A +A G D
Sbjct: 971 GHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGD 1007
Score = 33.9 bits (76), Expect = 0.30
Identities = 34/109 (31%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLL---------RHGADVNCHQHEHGY 81
LL+ K VRV+ LD+ G L+H+A +G D+ + LL + G H +
Sbjct: 978 LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQAL 1037
Query: 82 TALMFAALSGNKDITWVMLEAGAETDV-VNSV----GRTAAQMAAFVGQ 125
TA AA G+ + +L E +V VN G TA AA G+
Sbjct: 1038 TA---AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083
Score = 29.3 bits (64), Expect = 7.5
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L + ++ D+NG TPL AA+ G + L+ GA + H G L A
Sbjct: 1189 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE-HVDHSGMRPLDRAIGCR 1247
Query: 92 NKDITWVMLEAGAE 105
N + +L GA+
Sbjct: 1248 NTSVVVALLRKGAK 1261
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 60.5 bits (145), Expect = 3e-09
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 1/99 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + VN D+ G TPLM AA +G L + LL GA ++ E G +AL +A L
Sbjct: 1130 LLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKE-GLSALSWACLK 1188
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G++ + ++E GA D + GRT +AAF G + V
Sbjct: 1189 GHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETV 1227
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/87 (36%), Positives = 47/87 (54%), Gaps = 1/87 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G T L AA +GKL++C+LLL HGA V+ + G L AA G+ I ++LE G +
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVS-RTNRRGVPPLFCAARQGHWQIVRLLLERGCD 1137
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
++ + GRT +AA G V +
Sbjct: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFL 1164
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/75 (36%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 26 QEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALM 85
+E TLL ++ ENGMT L +AA G + + LL + G V+ H + G AL+
Sbjct: 948 EEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALV 1006
Query: 86 FAALSGNKDITWVML 100
+AL G+ DI +L
Sbjct: 1007 HSALRGHGDILQYLL 1021
Score = 35.0 bits (79), Expect = 0.14
Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
+L NV N L ++ G ++ LLL GA ++ E+G TAL +AA +
Sbjct: 920 ILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLD-GTSENGMTALCYAAAA 978
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHD 127
G+ + ++ + G D ++ G+ A +A G D
Sbjct: 979 GHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGD 1015
Score = 33.9 bits (76), Expect = 0.30
Identities = 34/109 (31%), Positives = 49/109 (44%), Gaps = 17/109 (15%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLL---------RHGADVNCHQHEHGY 81
LL+ K VRV+ LD+ G L+H+A +G D+ + LL + G H +
Sbjct: 986 LLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQAL 1045
Query: 82 TALMFAALSGNKDITWVMLEAGAETDV-VNSV----GRTAAQMAAFVGQ 125
TA AA G+ + +L E +V VN G TA AA G+
Sbjct: 1046 TA---AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091
Score = 29.3 bits (64), Expect = 7.5
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 32 LSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSG 91
L + ++ D+NG TPL AA+ G + L+ GA + H G L A
Sbjct: 1197 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE-HVDHSGMRPLDRAIGCR 1255
Query: 92 NKDITWVMLEAGAE 105
N + +L GA+
Sbjct: 1256 NTSVVVALLRKGAK 1269
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 60.5 bits (145), Expect = 3e-09
Identities = 41/136 (30%), Positives = 65/136 (47%), Gaps = 4/136 (2%)
Query: 3 HIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMC 62
H ++ QEE ++ + G V +L + N D NG T L +A +GK
Sbjct: 5 HCRRNPELQEELQIQAAVAAGDVHTVRKMLE-QGYSPNGRDANGWTLLHFSAARGKERCV 63
Query: 63 KLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSV---GRTAAQM 119
++ L HGAD G+TAL +AA+ G I +MLE+ +D++N+ G T +
Sbjct: 64 RVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHV 123
Query: 120 AAFVGQHDCVTIINNF 135
AA G+ V ++ F
Sbjct: 124 AAHYGRDSFVRLLLEF 139
Score = 38.1 bits (87), Expect = 0.016
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
+NG L +A K C++ L+ GAD N + E G T L +AL + ++ G
Sbjct: 179 QNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYG 237
Query: 104 AETDVVNSVGRT 115
A+T+ N G+T
Sbjct: 238 ADTNTRNYEGQT 249
Score = 37.7 bits (86), Expect = 0.021
Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL V+ L + G TPL A + + K+LL H A+++ ++G+ L +A +
Sbjct: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI---QNGF-LLRYAVIK 190
Query: 91 GNKDITWVMLEAGAETDVVN-SVGRTAAQMAAFVGQHDCVTIINNF 135
N + L+ GA+T++ G+T ++A C ++ N+
Sbjct: 191 SNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNY 236
Score = 33.9 bits (76), Expect = 0.30
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
+N +G TPL AA+ G+ +LLL A+V+ + G T L A + +
Sbjct: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVD-PLSDKGTTPLQLAIIRERSSCVKI 168
Query: 99 MLEAGAETDVVN 110
+L+ A D+ N
Sbjct: 169 LLDHNANIDIQN 180
Score = 28.9 bits (63), Expect = 9.7
Identities = 14/49 (28%), Positives = 26/49 (53%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGN 92
E+G TPL +A + + ++L +GAD N +E + ++SG+
Sbjct: 212 EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGS 260
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 60.5 bits (145), Expect = 3e-09
Identities = 41/136 (30%), Positives = 65/136 (47%), Gaps = 4/136 (2%)
Query: 3 HIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMC 62
H ++ QEE ++ + G V +L + N D NG T L +A +GK
Sbjct: 5 HCRRNPELQEELQIQAAVAAGDVHTVRKMLE-QGYSPNGRDANGWTLLHFSAARGKERCV 63
Query: 63 KLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSV---GRTAAQM 119
++ L HGAD G+TAL +AA+ G I +MLE+ +D++N+ G T +
Sbjct: 64 RVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHV 123
Query: 120 AAFVGQHDCVTIINNF 135
AA G+ V ++ F
Sbjct: 124 AAHYGRDSFVRLLLEF 139
Score = 38.1 bits (87), Expect = 0.016
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAG 103
+NG L +A K C++ L+ GAD N + E G T L +AL + ++ G
Sbjct: 179 QNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYG 237
Query: 104 AETDVVNSVGRT 115
A+T+ N G+T
Sbjct: 238 ADTNTRNYEGQT 249
Score = 37.7 bits (86), Expect = 0.021
Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL V+ L + G TPL A + + K+LL H A+++ ++G+ L +A +
Sbjct: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI---QNGF-LLRYAVIK 190
Query: 91 GNKDITWVMLEAGAETDVVN-SVGRTAAQMAAFVGQHDCVTIINNF 135
N + L+ GA+T++ G+T ++A C ++ N+
Sbjct: 191 SNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNY 236
Score = 33.9 bits (76), Expect = 0.30
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
+N +G TPL AA+ G+ +LLL A+V+ + G T L A + +
Sbjct: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVD-PLSDKGTTPLQLAIIRERSSCVKI 168
Query: 99 MLEAGAETDVVN 110
+L+ A D+ N
Sbjct: 169 LLDHNANIDIQN 180
Score = 28.9 bits (63), Expect = 9.7
Identities = 14/49 (28%), Positives = 26/49 (53%)
Query: 44 ENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGN 92
E+G TPL +A + + ++L +GAD N +E + ++SG+
Sbjct: 212 EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGS 260
>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
Length = 282
Score = 59.7 bits (143), Expect = 5e-09
Identities = 32/97 (32%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 9 LTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRH 68
+ +E+K + + + + + SKNV VN DE G L A +G ++ +LL+H
Sbjct: 155 IREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQH 214
Query: 69 GADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
AD+NC +E G TAL +A+ DI ++L++GA+
Sbjct: 215 RADINCQDNE-GQTALHYASACEFLDIVELLLQSGAD 250
>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
Length = 860
Score = 59.7 bits (143), Expect = 5e-09
Identities = 41/115 (35%), Positives = 60/115 (52%), Gaps = 4/115 (3%)
Query: 9 LTQEEKE---LLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLL 65
L QE+ L+ + G + LL +K +VN +NG T L+HAA K L +L
Sbjct: 594 LDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAIL 653
Query: 66 LRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
L GA VN Q +G TALM A GN DI +++E GA+ ++++ +A A
Sbjct: 654 LEAGAFVNV-QQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALHFA 707
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/102 (37%), Positives = 56/102 (54%), Gaps = 1/102 (0%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
L S++ ++ D +GMT +M AA G+ D+ +LL+ GA VN Q ++G TAL+ AA
Sbjct: 586 LNSNEEYNLDQEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQ-KNGTTALIHAAEK 644
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++LEAGA +V S G TA A G D V ++
Sbjct: 645 NFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLV 686
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 59.7 bits (143), Expect = 5e-09
Identities = 37/99 (37%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL K N NG TPL A K ++ + +LL+++GA + E G T + AA
Sbjct: 362 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFM 420
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G+ +I ++L+ GA DV N G TA MAA GQ + V
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 459
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 1/116 (0%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L V K + LL + + +NG+TPL AA+ + LLL GA +
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 77 HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++GYT L AA I +L GAET++V G T +A+ G D VT++
Sbjct: 606 -KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 52.0 bits (123), Expect = 1e-06
Identities = 31/103 (30%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL K ++ ++G+T L AA + K+++ +L +HGAD + H + GYT L+ A
Sbjct: 658 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KLGYTPLIVACH 716
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
GN + +L+ GA + G T AA G + ++
Sbjct: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/100 (34%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL ++ V+ NG+TPL A+ +G +M KLLL G ++ + G T L AA
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-GLTPLHCAAR 287
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
SG+ + ++LE GA G + MAA +CV
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327
Score = 50.4 bits (119), Expect = 3e-06
Identities = 30/79 (37%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G TPL+ A + G + M LL+ GA+VN + ++GYT L AA G+ I V+L+ GA+
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Query: 106 TDVVNSVGRTAAQMAAFVG 124
+ + G TA +A +G
Sbjct: 766 PNATTANGNTALAIAKRLG 784
Score = 48.9 bits (115), Expect = 9e-06
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G VQE L + V+ + G T L A+ G+ ++ K+L++ GA++N Q ++G+T
Sbjct: 57 GLVQE----LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA-QSQNGFT 111
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
L AA + D+ +LE GA G T +A G + V I+
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 39 VNCLDENG----------MTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAA 88
V CL NG TPL A+ GK ++ +LLL+H A + +GYT L +A
Sbjct: 459 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISA 517
Query: 89 LSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G D+ V+LEAGA + G T +AA G D ++
Sbjct: 518 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
VN E+G TPL AA+ G +++ LLL GA V+ +G T L A+ GN ++ +
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKL 263
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+L+ G + D G T AA G V ++
Sbjct: 264 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/111 (29%), Positives = 54/111 (48%), Gaps = 2/111 (1%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
K +Q A TLL+ N + + G+TPL A+ +G DM LLL GA+++ + G
Sbjct: 618 KNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM-STKSGL 675
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
T+L AA ++ ++ + GA+ D +G T +A G V +
Sbjct: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 1/111 (0%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGA 70
+EE+ L + + E LL + NG TPL +A +G++D+ +LL GA
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 71 DVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
+ + G+T L AA G+ D+ ++L+ A D G T +AA
Sbjct: 534 -AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Score = 43.1 bits (100), Expect = 5e-04
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Query: 10 TQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG 69
T++ L + E +L + +N +NG TPL AA + +D+ K LL +G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
A+ + E G+T L A G+ ++LE
Sbjct: 133 ANQST-ATEDGFTPLAVALQQGHNQAVAILLE 163
Score = 42.7 bits (99), Expect = 7e-04
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 51 MHAAYKGKLDMCKLLLRHGADVN-CHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVV 109
+ AA G LD L+ G D+N C+Q+ G AL AA G+ + +L G+ D
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQN--GLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 110 NSVGRTAAQMAAFVGQHDCVTII 132
G TA +A+ GQ + V ++
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVL 95
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G T L AA G++++ + LLR+GA V+ E T L A+ G +I ++L+ A
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAH 501
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
D + G T ++A GQ D +++
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVL 528
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G V+ LL + VN +NG TPL AA +G + +LL+HGA N +G T
Sbjct: 718 GNVKMVNFLLK-QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNT 775
Query: 83 ALMFAALSG 91
AL A G
Sbjct: 776 ALAIAKRLG 784
Score = 30.4 bits (67), Expect = 3.3
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + + +NG++PL AA ++ K LL+H A V+ ++ TAL AA
Sbjct: 296 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHC 354
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
G+ +T ++L+ A + G T +A
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIA 384
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 59.7 bits (143), Expect = 5e-09
Identities = 37/99 (37%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL K N NG TPL A K ++ + +LL+++GA + E G T + AA
Sbjct: 383 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFM 441
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G+ +I ++L+ GA DV N G TA MAA GQ + V
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 1/116 (0%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L V K + LL + + +NG+TPL AA+ + LLL GA +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 77 HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++GYT L AA I +L GAET++V G T +A+ G D VT++
Sbjct: 627 -KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 52.0 bits (123), Expect = 1e-06
Identities = 31/103 (30%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL K ++ ++G+T L AA + K+++ +L +HGAD + H + GYT L+ A
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KLGYTPLIVACH 737
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
GN + +L+ GA + G T AA G + ++
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/100 (34%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL ++ V+ NG+TPL A+ +G +M KLLL G ++ + G T L AA
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-GLTPLHCAAR 308
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
SG+ + ++LE GA G + MAA +CV
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Score = 50.4 bits (119), Expect = 3e-06
Identities = 30/79 (37%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G TPL+ A + G + M LL+ GA+VN + ++GYT L AA G+ I V+L+ GA+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 106 TDVVNSVGRTAAQMAAFVG 124
+ + G TA +A +G
Sbjct: 787 PNATTANGNTALAIAKRLG 805
Score = 48.9 bits (115), Expect = 9e-06
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G VQE L + V+ + G T L A+ G+ ++ K+L++ GA++N Q ++G+T
Sbjct: 78 GLVQE----LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA-QSQNGFT 132
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
L AA + D+ +LE GA G T +A G + V I+
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 39 VNCLDENG----------MTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAA 88
V CL NG TPL A+ GK ++ +LLL+H A + +GYT L +A
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISA 538
Query: 89 LSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G D+ V+LEAGA + G T +AA G D ++
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
VN E+G TPL AA+ G +++ LLL GA V+ +G T L A+ GN ++ +
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKL 284
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+L+ G + D G T AA G V ++
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/111 (29%), Positives = 54/111 (48%), Gaps = 2/111 (1%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
K +Q A TLL+ N + + G+TPL A+ +G DM LLL GA+++ + G
Sbjct: 639 KNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM-STKSGL 696
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
T+L AA ++ ++ + GA+ D +G T +A G V +
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 1/111 (0%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGA 70
+EE+ L + + E LL + NG TPL +A +G++D+ +LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 71 DVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
+ + G+T L AA G+ D+ ++L+ A D G T +AA
Sbjct: 555 -AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Score = 43.1 bits (100), Expect = 5e-04
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Query: 10 TQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG 69
T++ L + E +L + +N +NG TPL AA + +D+ K LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
A+ + E G+T L A G+ ++LE
Sbjct: 154 ANQST-ATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 42.7 bits (99), Expect = 7e-04
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 51 MHAAYKGKLDMCKLLLRHGADVN-CHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVV 109
+ AA G LD L+ G D+N C+Q+ G AL AA G+ + +L G+ D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQN--GLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 110 NSVGRTAAQMAAFVGQHDCVTII 132
G TA +A+ GQ + V ++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVL 116
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G T L AA G++++ + LLR+GA V+ E T L A+ G +I ++L+ A
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
D + G T ++A GQ D +++
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVL 549
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G V+ LL + VN +NG TPL AA +G + +LL+HGA N +G T
Sbjct: 739 GNVKMVNFLLK-QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNT 796
Query: 83 ALMFAALSG 91
AL A G
Sbjct: 797 ALAIAKRLG 805
Score = 30.4 bits (67), Expect = 3.3
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + + +NG++PL AA ++ K LL+H A V+ ++ TAL AA
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHC 375
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
G+ +T ++L+ A + G T +A
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIA 405
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 59.7 bits (143), Expect = 5e-09
Identities = 37/99 (37%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL K N NG TPL A K ++ + +LL+++GA + E G T + AA
Sbjct: 383 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFM 441
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
G+ +I ++L+ GA DV N G TA MAA GQ + V
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Score = 54.7 bits (130), Expect = 2e-07
Identities = 37/116 (31%), Positives = 54/116 (46%), Gaps = 1/116 (0%)
Query: 17 LEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQ 76
L V K + LL + + +NG+TPL AA+ + LLL GA +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 77 HEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
++GYT L AA I +L GAET++V G T +A+ G D VT++
Sbjct: 627 -KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 52.0 bits (123), Expect = 1e-06
Identities = 31/103 (30%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL K ++ ++G+T L AA + K+++ +L +HGAD + H + GYT L+ A
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT-KLGYTPLIVACH 737
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
GN + +L+ GA + G T AA G + ++
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 50.8 bits (120), Expect = 2e-06
Identities = 34/100 (34%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Query: 30 TLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAAL 89
TLL ++ V+ NG+TPL A+ +G +M KLLL G ++ + G T L AA
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-GLTPLHCAAR 308
Query: 90 SGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCV 129
SG+ + ++LE GA G + MAA +CV
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Score = 50.4 bits (119), Expect = 3e-06
Identities = 30/79 (37%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G TPL+ A + G + M LL+ GA+VN + ++GYT L AA G+ I V+L+ GA+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 106 TDVVNSVGRTAAQMAAFVG 124
+ + G TA +A +G
Sbjct: 787 PNATTANGNTALAIAKRLG 805
Score = 48.9 bits (115), Expect = 9e-06
Identities = 33/110 (30%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G VQE L + V+ + G T L A+ G+ ++ K+L++ GA++N Q ++G+T
Sbjct: 78 GLVQE----LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA-QSQNGFT 132
Query: 83 ALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
L AA + D+ +LE GA G T +A G + V I+
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 48.1 bits (113), Expect = 2e-05
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 39 VNCLDENG----------MTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAA 88
V CL NG TPL A+ GK ++ +LLL+H A + +GYT L +A
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISA 538
Query: 89 LSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
G D+ V+LEAGA + G T +AA G D ++
Sbjct: 539 REGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
Query: 39 VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWV 98
VN E+G TPL AA+ G +++ LLL GA V+ +G T L A+ GN ++ +
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKL 284
Query: 99 MLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
+L+ G + D G T AA G V ++
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/111 (29%), Positives = 54/111 (48%), Gaps = 2/111 (1%)
Query: 22 KGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGY 81
K +Q A TLL+ N + + G+TPL A+ +G DM LLL GA+++ + G
Sbjct: 639 KNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM-STKSGL 696
Query: 82 TALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTII 132
T+L AA ++ ++ + GA+ D +G T +A G V +
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 1/111 (0%)
Query: 11 QEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGA 70
+EE+ L + + E LL + NG TPL +A +G++D+ +LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 71 DVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAA 121
+ + G+T L AA G+ D+ ++L+ A D G T +AA
Sbjct: 555 -AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Score = 43.1 bits (100), Expect = 5e-04
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Query: 10 TQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHG 69
T++ L + E +L + +N +NG TPL AA + +D+ K LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 70 ADVNCHQHEHGYTALMFAALSGNKDITWVMLE 101
A+ + E G+T L A G+ ++LE
Sbjct: 154 ANQST-ATEDGFTPLAVALQQGHNQAVAILLE 184
Score = 42.7 bits (99), Expect = 7e-04
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)
Query: 51 MHAAYKGKLDMCKLLLRHGADVN-CHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVV 109
+ AA G LD L+ G D+N C+Q+ G AL AA G+ + +L G+ D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQN--GLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 110 NSVGRTAAQMAAFVGQHDCVTII 132
G TA +A+ GQ + V ++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVL 116
Score = 40.8 bits (94), Expect = 0.002
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 46 GMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAE 105
G T L AA G++++ + LLR+GA V+ E T L A+ G +I ++L+ A
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 106 TDVVNSVGRTAAQMAAFVGQHDCVTII 132
D + G T ++A GQ D +++
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVL 549
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 23 GTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYT 82
G V+ LL + VN +NG TPL AA +G + +LL+HGA N +G T
Sbjct: 739 GNVKMVNFLLK-QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA-TTANGNT 796
Query: 83 ALMFAALSG 91
AL A G
Sbjct: 797 ALAIAKRLG 805
Score = 30.4 bits (67), Expect = 3.3
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 1/90 (1%)
Query: 31 LLSSKNVRVNCLDENGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALS 90
LL + + +NG++PL AA ++ K LL+H A V+ ++ TAL AA
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHC 375
Query: 91 GNKDITWVMLEAGAETDVVNSVGRTAAQMA 120
G+ +T ++L+ A + G T +A
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,147,565
Number of Sequences: 37866
Number of extensions: 787076
Number of successful extensions: 5622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 3507
Number of HSP's gapped (non-prelim): 1675
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.