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Search of human proteins with 27734721
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
(829 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 1670 0.0
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 1556 0.0
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 1094 0.0
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 1078 0.0
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 1012 0.0
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 935 0.0
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 736 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 226 5e-59
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 226 5e-59
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 226 5e-59
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 226 5e-59
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 224 3e-58
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 224 3e-58
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 224 3e-58
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 218 2e-56
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 218 2e-56
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 214 3e-55
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 214 3e-55
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 214 3e-55
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 214 3e-55
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 191 2e-48
gi|4826894 phosphodiesterase 1C [Homo sapiens] 179 7e-45
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 173 7e-43
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 173 7e-43
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 173 7e-43
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 171 2e-42
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 171 2e-42
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 171 2e-42
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 171 2e-42
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 171 2e-42
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 1670 bits (4325), Expect = 0.0
Identities = 829/829 (100%), Positives = 829/829 (100%)
Query: 1 MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG 60
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG
Sbjct: 1 MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG 60
Query: 61 KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF 120
KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF
Sbjct: 61 KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF 120
Query: 121 LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF 180
LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF
Sbjct: 121 LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF 180
Query: 181 TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA 240
TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA
Sbjct: 181 TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA 240
Query: 241 NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI 300
NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI
Sbjct: 241 NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI 300
Query: 301 QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL 360
QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL
Sbjct: 301 QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL 360
Query: 361 DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE 420
DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE
Sbjct: 361 DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE 420
Query: 421 ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS 480
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS
Sbjct: 421 ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS 480
Query: 481 LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS 540
LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS
Sbjct: 481 LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS 540
Query: 541 WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 600
WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH
Sbjct: 541 WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 600
Query: 601 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG 660
PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG
Sbjct: 601 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG 660
Query: 661 IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM 720
IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM
Sbjct: 661 IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM 720
Query: 721 LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS 780
LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS
Sbjct: 721 LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS 780
Query: 781 FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
Sbjct: 781 FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 1556 bits (4030), Expect = 0.0
Identities = 783/829 (94%), Positives = 783/829 (94%), Gaps = 46/829 (5%)
Query: 1 MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG 60
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG
Sbjct: 1 MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG 60
Query: 61 KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF 120
KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF
Sbjct: 61 KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF 120
Query: 121 LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF 180
LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF
Sbjct: 121 LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF 180
Query: 181 TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA 240
TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQ
Sbjct: 181 TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQ-- 238
Query: 241 NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI 300
EWQGIYYAKKKNGDNI
Sbjct: 239 --------------------------------------------EWQGIYYAKKKNGDNI 254
Query: 301 QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL 360
QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL
Sbjct: 255 QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL 314
Query: 361 DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE 420
DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE
Sbjct: 315 DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE 374
Query: 421 ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS 480
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS
Sbjct: 375 ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS 434
Query: 481 LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS 540
LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS
Sbjct: 435 LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS 494
Query: 541 WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 600
WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH
Sbjct: 495 WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 554
Query: 601 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG 660
PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG
Sbjct: 555 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG 614
Query: 661 IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM 720
IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM
Sbjct: 615 IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM 674
Query: 721 LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS 780
LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS
Sbjct: 675 LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS 734
Query: 781 FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
Sbjct: 735 FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 783
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 1094 bits (2829), Expect = 0.0
Identities = 553/889 (62%), Positives = 681/889 (76%), Gaps = 65/889 (7%)
Query: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
+EL GS K+V+ A+V
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFET 246
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQY NPAFE
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER 300
Query: 247 TMGYQSGELIGKELGEVPINEK-KADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVK 305
MGY GEL+GKEL ++P ++K +ADLLDTIN+CI+ GKEWQG+YYA++K+GD+IQQ+VK
Sbjct: 301 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK 360
Query: 306 IIPVIGQGGKIRHYVSIIRVC---NGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDV 362
I PVIGQGGKIRH+VS+ ++C + N + KI ++ T+ + ++K+RRK S+DV
Sbjct: 361 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV 420
Query: 363 KAVASRATEVSS--QRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE 420
K+++SR ++ S RR+ SMARIHSMTIEAPITKVINIINAAQE+SP+ V EALDRVLE
Sbjct: 421 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE 480
Query: 421 ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS 480
ILRTTELYSPQ G KD+DPH +DLVGGLM+DGLRRLSGNEYV TKN S++ PI+
Sbjct: 481 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVF-TKNVHQSHSHLAMPIT 539
Query: 481 LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS 540
++DVPP I++ ++NEE WDF+IFELEA TH RPL+YLGLK+F+RFG+CEFL+CSE+TLR+
Sbjct: 540 INDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRA 599
Query: 541 WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH 600
W Q+IEANYHSSN YHNSTH+ADVLHATA+FL KER+K +LD +DEVAALIAAT+HDVDH
Sbjct: 600 WFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDH 659
Query: 601 PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG 660
PGRTNSFLCNAGSELA+LYNDTAVLESHH ALAFQLT D KCNIFKN++RN YRTLRQ
Sbjct: 660 PGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQA 719
Query: 661 IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM 720
IIDMVLATEMTKHFEHVNKFVNSINKP+A E + + N N PEN+ LIKRM
Sbjct: 720 IIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN----FPENQILIKRM 775
Query: 721 LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS 780
+IKCADV+NPCRPL CIEWA RISEEYF+QTDEEK+QGLPVVMPVFDRNTCSIPKSQIS
Sbjct: 776 MIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQIS 835
Query: 781 FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
FIDYFITDMFDAWDAF LP LMQHL +N+K+WK LD++K ++LR P +
Sbjct: 836 FIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSD 884
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 1078 bits (2788), Expect = 0.0
Identities = 546/869 (62%), Positives = 671/869 (77%), Gaps = 45/869 (5%)
Query: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 50 --------LLESELRDGS--GKKVAVADVQFGPMRFH-----------QDQLQVLLVFTK 88
+EL GS G A G R ++VLL+F K
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKVLLIFAK 120
Query: 89 EDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIR 148
ED+Q +GF AC++AG++C + + ++ L CFLDKHH+II+IDHR + DAEA+CRSIR
Sbjct: 121 EDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIR 180
Query: 149 SSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVR 206
++ SE+TVI+ VV RV D EE SV+P + AGF RR++EN +I+ACYNEL+Q+E GEVR
Sbjct: 181 ATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVR 240
Query: 207 SQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPIN 266
SQ KLRACNSVFTAL++ +AIEITS+D IQY NPAFE MGY GEL+GKEL ++P +
Sbjct: 241 SQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKS 300
Query: 267 EK-KADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRV 325
+K +ADLLDTIN+CI+ GKEWQG+YYA++K+GD+IQQ+VKI PVIGQGGKIRH+VS+ ++
Sbjct: 301 DKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKL 360
Query: 326 C---NGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSS--QRRHSS 380
C + N + KI ++ T+ + ++K+RRK S+DVK+++SR ++ S RR+ S
Sbjct: 361 CCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPS 420
Query: 381 MARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPH 440
MARIHSMTIEAPITKVINIINAAQE+SP+ V EALDRVLEILRTTELYSPQ G KD+DPH
Sbjct: 421 MARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPH 480
Query: 441 ANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDF 500
+DLVGGLM+DGLRRLSGNEYV TKN S++ PI+++DVPP I++ ++NEE WDF
Sbjct: 481 TSDLVGGLMTDGLRRLSGNEYVF-TKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF 539
Query: 501 DIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTH 560
+IFELEA TH RPL+YLGLK+F+RFG+CEFL+CSE+TLR+W Q+IEANYHSSN YHNSTH
Sbjct: 540 NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH 599
Query: 561 SADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYN 620
+ADVLHATA+FL KER+K +LD +DEVAALIAAT+HDVDHPGRTNSFLCNAGSELA+LYN
Sbjct: 600 AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 659
Query: 621 DTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKF 680
DTAVLESHH ALAFQLT D KCNIFKN++RN YRTLRQ IIDMVLATEMTKHFEHVNKF
Sbjct: 660 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 719
Query: 681 VNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEW 740
VNSINKP+A E + + N N PEN+ LIKRM+IKCADV+NPCRPL CIEW
Sbjct: 720 VNSINKPMAAEIEGSDCECNPAGKN----FPENQILIKRMMIKCADVANPCRPLDLCIEW 775
Query: 741 AARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLP 800
A RISEEYF+QTDEEK+QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAF LP
Sbjct: 776 AGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 835
Query: 801 DLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
LMQHL +N+K+WK LD++K ++LR P +
Sbjct: 836 ALMQHLADNYKHWKTLDDLKCKSLRLPSD 864
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 1012 bits (2616), Expect = 0.0
Identities = 523/888 (58%), Positives = 643/888 (72%), Gaps = 110/888 (12%)
Query: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
+EL GS K+V+ A+V
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFET 246
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQ
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ-------- 292
Query: 247 TMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKI 306
EWQG+YYA++K+GD+IQQ+VKI
Sbjct: 293 --------------------------------------EWQGVYYARRKSGDSIQQHVKI 314
Query: 307 IPVIGQGGKIRHYVSIIRVC---NGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVK 363
PVIGQGGKIRH+VS+ ++C + N + KI ++ T+ + ++K+RRK S+DVK
Sbjct: 315 TPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVK 374
Query: 364 AVASRATEVSS--QRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEI 421
+++SR ++ S RR+ SMARIHSMTIEAPITKVINIINAAQE+SP+ V EALDRVLEI
Sbjct: 375 SISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEI 434
Query: 422 LRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISL 481
LRTTELYSPQ G KD+DPH +DLVGGLM+DGLRRLSGNEYV TKN S++ PI++
Sbjct: 435 LRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVF-TKNVHQSHSHLAMPITI 493
Query: 482 DDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSW 541
+DVPP I++ ++NEE WDF+IFELEA TH RPL+YLGLK+F+RFG+CEFL+CSE+TLR+W
Sbjct: 494 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW 553
Query: 542 LQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHP 601
Q+IEANYHSSN YHNSTH+ADVLHATA+FL KER+K +LD +DEVAALIAAT+HDVDHP
Sbjct: 554 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP 613
Query: 602 GRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGI 661
GRTNSFLCNAGSELA+LYNDTAVLESHH ALAFQLT D KCNIFKN++RN YRTLRQ I
Sbjct: 614 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI 673
Query: 662 IDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRML 721
IDMVLATEMTKHFEHVNKFVNSINKP+A E + + N N PEN+ LIKRM+
Sbjct: 674 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN----FPENQILIKRMM 729
Query: 722 IKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISF 781
IKCADV+NPCRPL CIEWA RISEEYF+QTDEEK+QGLPVVMPVFDRNTCSIPKSQISF
Sbjct: 730 IKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISF 789
Query: 782 IDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
IDYFITDMFDAWDAF LP LMQHL +N+K+WK LD++K ++LR P +
Sbjct: 790 IDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSD 837
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 935 bits (2416), Expect = 0.0
Identities = 489/884 (55%), Positives = 613/884 (69%), Gaps = 110/884 (12%)
Query: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
+EL GS K+V+ A+V
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFET 246
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQY NPAFE
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER 300
Query: 247 TMGYQSGELIGKELGEVPINEK-KADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVK 305
MGY GEL+GKEL ++P ++K +ADLLDTIN+CI+ GKEWQG+YYA++K+GD+IQQ+VK
Sbjct: 301 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK 360
Query: 306 IIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAV 365
I PVIGQGGKIRH+VS+ ++C + ++I + + D+ ++QT H R K
Sbjct: 361 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHK-IHRDSGDNSQTEPHSFRYKN------- 412
Query: 366 ASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTT 425
RR S+ + I++ +P + I
Sbjct: 413 ----------RRKESID--------------VKSISSRGSDAPSLQNRRYPSMARI---- 444
Query: 426 ELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVP 485
H+ + + DGLRRLSGNEYV TKN S++ PI+++DVP
Sbjct: 445 --------------HSMTIEAPITKDGLRRLSGNEYVF-TKNVHQSHSHLAMPITINDVP 489
Query: 486 PRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQII 545
P I++ ++NEE WDF+IFELEA TH RPL+YLGLK+F+RFG+CEFL+CSE+TLR+W Q+I
Sbjct: 490 PCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVI 549
Query: 546 EANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTN 605
EANYHSSN YHNSTH+ADVLHATA+FL KER+K +LD +DEVAALIAAT+HDVDHPGRTN
Sbjct: 550 EANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTN 609
Query: 606 SFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMV 665
SFLCNAGSELA+LYNDTAVLESHH ALAFQLT D KCNIFKN++RN YRTLRQ IIDMV
Sbjct: 610 SFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMV 669
Query: 666 LATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCA 725
LATEMTKHFEHVNKFVNSINKP+A E + + N N PEN+ LIKRM+IKCA
Sbjct: 670 LATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKN----FPENQILIKRMMIKCA 725
Query: 726 DVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYF 785
DV+NPCRPL CIEWA RISEEYF+QTDEEK+QGLPVVMPVFDRNTCSIPKSQISFIDYF
Sbjct: 726 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF 785
Query: 786 ITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
ITDMFDAWDAF LP LMQHL +N+K+WK LD++K ++LR P +
Sbjct: 786 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSD 829
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 736 bits (1899), Expect = 0.0
Identities = 360/498 (72%), Positives = 422/498 (84%), Gaps = 7/498 (1%)
Query: 334 KISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSS--QRRHSSMARIHSMTIEA 391
KI ++ T+ + ++K+RRK S+DVK+++SR ++ S RR+ SMARIHSMTIEA
Sbjct: 295 KIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEA 354
Query: 392 PITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSD 451
PITKVINIINAAQE+SP+ V EALDRVLEILRTTELYSPQ G KD+DPH +DLVGGLM+D
Sbjct: 355 PITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTD 414
Query: 452 GLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHN 511
GLRRLSGNEYV TKN S++ PI+++DVPP I++ ++NEE WDF+IFELEA TH
Sbjct: 415 GLRRLSGNEYVF-TKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHK 473
Query: 512 RPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYF 571
RPL+YLGLK+F+RFG+CEFL+CSE+TLR+W Q+IEANYHSSN YHNSTH+ADVLHATA+F
Sbjct: 474 RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFF 533
Query: 572 LSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAA 631
L KER+K +LD +DEVAALIAAT+HDVDHPGRTNSFLCNAGSELA+LYNDTAVLESHH A
Sbjct: 534 LGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTA 593
Query: 632 LAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATL 691
LAFQLT D KCNIFKN++RN YRTLRQ IIDMVLATEMTKHFEHVNKFVNSINKP+A
Sbjct: 594 LAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAE 653
Query: 692 EENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQ 751
E + + N N PEN+ LIKRM+IKCADV+NPCRPL CIEWA RISEEYF+Q
Sbjct: 654 IEGSDCECNPAGKN----FPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQ 709
Query: 752 TDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFK 811
TDEEK+QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAF LP LMQHL +N+K
Sbjct: 710 TDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYK 769
Query: 812 YWKGLDEMKLRNLRPPPE 829
+WK LD++K ++LR P +
Sbjct: 770 HWKTLDDLKCKSLRLPSD 787
Score = 236 bits (601), Expect = 8e-62
Identities = 132/292 (45%), Positives = 178/292 (60%), Gaps = 54/292 (18%)
Query: 1 MGCAPSIHISERLV-----AEDAPSPAAPPLSSGGPRLP------QGQKTAALPRTRGAG 49
MGCAPSIH+S+ V ++++ SP S GP P Q A+P +R +G
Sbjct: 1 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG 60
Query: 50 --------LLESELRDGSG---------------------------------KKVAVADV 68
+EL GS K+V+ A+V
Sbjct: 61 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV 120
Query: 69 QFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDII 128
+ GPMR QD +QVLL+F KED+Q +GF AC++AG++C + + ++ L CFLDKHH+II
Sbjct: 121 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII 180
Query: 129 IIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRV--DREELSVMPFISAGFTRRYVE 186
+IDHR + DAEA+CRSIR++ SE+TVI+ VV RV D EE SV+P + AGF RR++E
Sbjct: 181 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME 240
Query: 187 NPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQ 238
N +I+ACYNEL+Q+E GEVRSQ KLRACNSVFTAL++ +AIEITS+D IQ
Sbjct: 241 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQ 292
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 226 bits (577), Expect = 5e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 458 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 517 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 565
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 566 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 624
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
+++ W V D D++ L++N +++ +
Sbjct: 625 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 226 bits (577), Expect = 5e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 443 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 502 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 550
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 551 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 609
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
+++ W V D D++ L++N +++ +
Sbjct: 610 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 226 bits (577), Expect = 5e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 286 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 345 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 393
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 394 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 452
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
+++ W V D D++ L++N +++ +
Sbjct: 453 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 226 bits (577), Expect = 5e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 397
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 398 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 457
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 458 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 516
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 517 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 565
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 566 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 624
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
+++ W V D D++ L++N +++ +
Sbjct: 625 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
Query: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
Query: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 387
Query: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 388 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 436
Query: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 437 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 495
Query: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
DY +++ W V D DL+ L++N ++++
Sbjct: 496 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
Query: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
Query: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 461
Query: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 462 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 510
Query: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 511 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 569
Query: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
DY +++ W V D DL+ L++N ++++
Sbjct: 570 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
Query: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
Query: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 493
Query: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 494 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 542
Query: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 601
Query: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
DY +++ W V D DL+ L++N ++++
Sbjct: 602 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 218 bits (555), Expect = 2e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 394 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 453
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 454 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 513
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 514 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 572
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 573 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 621
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 622 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 680
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
+++ W V D D++ L++N ++++
Sbjct: 681 PLWETWADLVHPDAQDILDTLEDNREWYQ 709
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 218 bits (555), Expect = 2e-56
Identities = 113/329 (34%), Positives = 194/329 (58%), Gaps = 15/329 (4%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +E+ W +F + + NRPL + +F + + TL ++L +E
Sbjct: 258 LAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLED 317
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHN+ H+ADV+ +T LS ++ ++ +AA+ A+ IHDVDHPG +N F
Sbjct: 318 HYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF 377
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND++VLE+HH A+ F+L ++ C+IF+N+ + ++LR+ +ID+VLA
Sbjct: 378 LINTNSELALMYNDSSVLENHHLAVGFKLLQ-EENCDIFQNLTKKQRQSLRKMVIDIVLA 436
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + + ++ CAD+
Sbjct: 437 TDMSKHM-----------NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADL 485
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PLQ +W RI EE+F Q D E+++G+ + P+ D++ S+ KSQ+ FIDY +
Sbjct: 486 SNPTKPLQLYRQWTDRIMEEFFRQGDRERERGME-ISPMCDKHNASVEKSQVGFIDYIVH 544
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
+++ W V D D++ L++N ++++
Sbjct: 545 PLWETWADLVHPDAQDILDTLEDNREWYQ 573
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 304 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 363
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 364 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 423
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 424 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 482
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 483 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 531
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 532 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 590
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 591 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 631
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 339 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 398
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 399 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 458
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 459 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 517
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 518 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 566
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 567 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 625
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 626 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 666
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 365 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 424
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 425 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 484
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 485 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 543
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 544 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 592
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 593 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 651
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 652 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 692
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 214 bits (545), Expect = 3e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 126 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 185
Query: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 186 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 245
Query: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 246 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 304
Query: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 305 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 353
Query: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 354 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 412
Query: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 413 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 453
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 191 bits (485), Expect = 2e-48
Identities = 114/366 (31%), Positives = 190/366 (51%), Gaps = 24/366 (6%)
Query: 454 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 513
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 84 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 143
Query: 514 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 573
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 144 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 203
Query: 574 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 633
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 204 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 263
Query: 634 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 693
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 264 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 320
Query: 694 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 753
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 321 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 363
Query: 754 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDL---PDLMQHLDNNF 810
EK+ L V P+ DR+T SI QI F+ Y + +F W F + ++ H+ N
Sbjct: 364 IEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNK 422
Query: 811 KYWKGL 816
WKGL
Sbjct: 423 ASWKGL 428
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 179 bits (455), Expect = 7e-45
Identities = 96/307 (31%), Positives = 161/307 (52%), Gaps = 24/307 (7%)
Query: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544
PP + A+++ + W FD+F L A+ + L ++ ++ R+ + S L S+++
Sbjct: 156 PPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEA 215
Query: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603
+E Y NPYHN H+ADV Y L K + L ++ A + +A IHD +H G
Sbjct: 216 LEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGT 275
Query: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663
TN+F S+ AILYND +VLE+HH + A++L D++ NI N+ ++D+R R +I+
Sbjct: 276 TNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIE 335
Query: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723
MV+AT+M+ HF+ + ++ +P E + + ++ ML T
Sbjct: 336 MVMATDMSCHFQQIKAMKTALQQP--------EAIEKPKALSLMLHT------------- 374
Query: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783
AD+S+P + W + EE+F Q D E + GLP P+ DR + + +SQ+ FID
Sbjct: 375 -ADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP-FSPLCDRKSTMVAQSQVGFID 432
Query: 784 YFITDMF 790
+ + F
Sbjct: 433 FIVEPTF 439
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 173 bits (438), Expect = 7e-43
Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)
Query: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544
P + +++ + W FD+F L A+ L ++ ++F R+ + S L ++ +
Sbjct: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
Query: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603
+E Y NPYHN H+ADV Y + I L ++ +A + AA IHD +H G
Sbjct: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
Query: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663
TN+F S++AILYND +VLE+HH + A++L +++ NI N+ ++D+R LR +I+
Sbjct: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
Query: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723
MVL+T+M+ HF+ + NS+ +P +R +++
Sbjct: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
Query: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783
AD+S+P + + W + EE+F Q D+E + GLP P+ DR + + +SQI FID
Sbjct: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
Query: 784 YFITDMF 790
+ + F
Sbjct: 423 FIVEPTF 429
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 173 bits (438), Expect = 7e-43
Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)
Query: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544
P + +++ + W FD+F L A+ L ++ ++F R+ + S L ++ +
Sbjct: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
Query: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603
+E Y NPYHN H+ADV Y + I L ++ +A + AA IHD +H G
Sbjct: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
Query: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663
TN+F S++AILYND +VLE+HH + A++L +++ NI N+ ++D+R LR +I+
Sbjct: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
Query: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723
MVL+T+M+ HF+ + NS+ +P +R +++
Sbjct: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
Query: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783
AD+S+P + + W + EE+F Q D+E + GLP P+ DR + + +SQI FID
Sbjct: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
Query: 784 YFITDMF 790
+ + F
Sbjct: 423 FIVEPTF 429
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 173 bits (438), Expect = 7e-43
Identities = 104/331 (31%), Positives = 173/331 (52%), Gaps = 21/331 (6%)
Query: 454 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 513
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 110 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 169
Query: 514 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 573
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 170 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 229
Query: 574 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 633
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 230 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 289
Query: 634 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 693
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 290 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 346
Query: 694 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 753
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 347 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 389
Query: 754 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 784
EK+ L V P+ DR+T SI QI Y
Sbjct: 390 IEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (434), Expect = 2e-42
Identities = 95/274 (34%), Positives = 151/274 (55%), Gaps = 28/274 (10%)
Query: 521 MFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHATAYFLSKERI 577
M+ G+ + TLR WL + NY + NP+HN H A ++++ + S +
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCS---L 126
Query: 578 KETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLT 637
+E D + + AA HD+DHPG N++ NA +ELA+ YND + LE+HH A+AFQ+
Sbjct: 127 QEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI- 185
Query: 638 TGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGET 697
+ +CNIF N+ + ++ +RQG+I ++LAT+M +H E ++ F
Sbjct: 186 LAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF----------------- 228
Query: 698 DKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQ 757
+++ N E+ TL+K +LIKC D+SN RP++ W + EEYF Q+D EK
Sbjct: 229 --KEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS 286
Query: 758 QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
+GLPV P DR+ + +QI FI + + MF+
Sbjct: 287 EGLPVA-PFMDRDKVTKATAQIGFIKFVLIPMFE 319
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (434), Expect = 2e-42
Identities = 95/274 (34%), Positives = 151/274 (55%), Gaps = 28/274 (10%)
Query: 521 MFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHATAYFLSKERI 577
M+ G+ + TLR WL + NY + NP+HN H A ++++ + S +
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCS---L 126
Query: 578 KETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLT 637
+E D + + AA HD+DHPG N++ NA +ELA+ YND + LE+HH A+AFQ+
Sbjct: 127 QEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI- 185
Query: 638 TGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGET 697
+ +CNIF N+ + ++ +RQG+I ++LAT+M +H E ++ F
Sbjct: 186 LAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF----------------- 228
Query: 698 DKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQ 757
+++ N E+ TL+K +LIKC D+SN RP++ W + EEYF Q+D EK
Sbjct: 229 --KEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS 286
Query: 758 QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
+GLPV P DR+ + +QI FI + + MF+
Sbjct: 287 EGLPVA-PFMDRDKVTKATAQIGFIKFVLIPMFE 319
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 171 bits (434), Expect = 2e-42
Identities = 95/274 (34%), Positives = 151/274 (55%), Gaps = 28/274 (10%)
Query: 521 MFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHATAYFLSKERI 577
M+ G+ + TLR WL + NY + NP+HN H A ++++ + S +
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCS---L 307
Query: 578 KETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLT 637
+E D + + AA HD+DHPG N++ NA +ELA+ YND + LE+HH A+AFQ+
Sbjct: 308 QEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI- 366
Query: 638 TGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGET 697
+ +CNIF N+ + ++ +RQG+I ++LAT+M +H E ++ F
Sbjct: 367 LAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF----------------- 409
Query: 698 DKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQ 757
+++ N E+ TL+K +LIKC D+SN RP++ W + EEYF Q+D EK
Sbjct: 410 --KEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS 467
Query: 758 QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
+GLPV P DR+ + +QI FI + + MF+
Sbjct: 468 EGLPVA-PFMDRDKVTKATAQIGFIKFVLIPMFE 500
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 171 bits (434), Expect = 2e-42
Identities = 95/274 (34%), Positives = 151/274 (55%), Gaps = 28/274 (10%)
Query: 521 MFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHATAYFLSKERI 577
M+ G+ + TLR WL + NY + NP+HN H A ++++ + S +
Sbjct: 237 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCS---L 292
Query: 578 KETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLT 637
+E D + + AA HD+DHPG N++ NA +ELA+ YND + LE+HH A+AFQ+
Sbjct: 293 QEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI- 351
Query: 638 TGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGET 697
+ +CNIF N+ + ++ +RQG+I ++LAT+M +H E ++ F
Sbjct: 352 LAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF----------------- 394
Query: 698 DKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQ 757
+++ N E+ TL+K +LIKC D+SN RP++ W + EEYF Q+D EK
Sbjct: 395 --KEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS 452
Query: 758 QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
+GLPV P DR+ + +QI FI + + MF+
Sbjct: 453 EGLPVA-PFMDRDKVTKATAQIGFIKFVLIPMFE 485
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 171 bits (434), Expect = 2e-42
Identities = 95/274 (34%), Positives = 151/274 (55%), Gaps = 28/274 (10%)
Query: 521 MFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHS---ADVLHATAYFLSKERI 577
M+ G+ + TLR WL + NY + NP+HN H A ++++ + S +
Sbjct: 211 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCS---L 266
Query: 578 KETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLT 637
+E D + + AA HD+DHPG N++ NA +ELA+ YND + LE+HH A+AFQ+
Sbjct: 267 QEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI- 325
Query: 638 TGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGET 697
+ +CNIF N+ + ++ +RQG+I ++LAT+M +H E ++ F
Sbjct: 326 LAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSF----------------- 368
Query: 698 DKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQ 757
+++ N E+ TL+K +LIKC D+SN RP++ W + EEYF Q+D EK
Sbjct: 369 --KEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS 426
Query: 758 QGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
+GLPV P DR+ + +QI FI + + MF+
Sbjct: 427 EGLPVA-PFMDRDKVTKATAQIGFIKFVLIPMFE 459
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,898,511
Number of Sequences: 37866
Number of extensions: 1358662
Number of successful extensions: 4541
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 4230
Number of HSP's gapped (non-prelim): 106
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.