Search of human proteins with 27436981

Search of human proteins with 27436981

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
         (647 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27436981 potassium voltage-gated channel, Shal-related subfam...  1299   0.0  
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   828   0.0  
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   815   0.0  
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   803   0.0  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   279   7e-75
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   279   7e-75
gi|88758565 potassium voltage-gated channel, shaker-related subf...   278   1e-74
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   275   9e-74
gi|25952092 potassium voltage-gated channel, shaker-related subf...   274   2e-73
gi|119395748 potassium voltage-gated channel subfamily A member ...   270   4e-72
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   269   7e-72
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   267   3e-71
gi|163792201 Shaw-related voltage-gated potassium channel protei...   267   3e-71
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   266   6e-71
gi|25952087 potassium voltage-gated channel, shaker-related subf...   264   2e-70
gi|88758576 Shaw-related voltage-gated potassium channel protein...   264   2e-70
gi|24497462 Shaw-related voltage-gated potassium channel protein...   264   2e-70
gi|24497464 Shaw-related voltage-gated potassium channel protein...   264   2e-70
gi|24497460 Shaw-related voltage-gated potassium channel protein...   261   1e-69
gi|4504821 potassium voltage-gated channel, shaker-related subfa...   256   6e-68
gi|21217561 Shaw-related voltage-gated potassium channel protein...   251   1e-66
gi|21217563 Shaw-related voltage-gated potassium channel protein...   251   1e-66
gi|24497458 Shaw-related voltage-gated potassium channel protein...   251   1e-66
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    251   2e-66
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   239   8e-63
gi|27436988 potassium voltage-gated channel, subfamily G, member...   236   4e-62
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   235   1e-61
gi|20070166 potassium voltage-gated channel, subfamily F, member...   233   4e-61
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   226   5e-59
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   218   1e-56

>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score = 1299 bits (3361), Expect = 0.0
 Identities = 647/647 (100%), Positives = 647/647 (100%)

Query: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR 60
           MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR
Sbjct: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR 60

Query: 61  YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
           YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF
Sbjct: 61  YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120

Query: 121 YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPH 180
           YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPH
Sbjct: 121 YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPH 180

Query: 181 TSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVL 240
           TSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVL
Sbjct: 181 TSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVL 240

Query: 241 IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVF 300
           IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVF
Sbjct: 241 IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVF 300

Query: 301 RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIP 360
           RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIP
Sbjct: 301 RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIP 360

Query: 361 AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR 420
           AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR
Sbjct: 361 AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR 420

Query: 421 ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHH 480
           ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHH
Sbjct: 421 ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHH 480

Query: 481 LLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRR 540
           LLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRR
Sbjct: 481 LLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRR 540

Query: 541 AIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIIS 600
           AIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIIS
Sbjct: 541 AIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIIS 600

Query: 601 IPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL 647
           IPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL
Sbjct: 601 IPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL 647


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  828 bits (2140), Expect = 0.0
 Identities = 431/640 (67%), Positives = 513/640 (80%), Gaps = 18/640 (2%)

Query: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVV-NVSGRRFETWKNTLD 59
           MAAG+A WLPFARAAA+GW+P+A  P+P  P  +  R  + L+V NVSG RF+TW++TL+
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLE 60

Query: 60  RYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELA 119
           RYPDTLLGSSE++FFY  ++ +YFFDRDPD+FRH+LNFYRTG+LH PR ECI A+DEELA
Sbjct: 61  RYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELA 120

Query: 120 FYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENP 179
           F+GL+PE++GDCC EEY+DR++ENAERL +D + + AG+  ALP  ++ RQR+WRAFENP
Sbjct: 121 FFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGES-ALPTMTA-RQRVWRAFENP 178

Query: 180 HTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACV 239
           HTST ALVFYYVTGFFIAVSVIANVVET+PC GS+    +E PCGER+  AFFC+DTACV
Sbjct: 179 HTSTMALVFYYVTGFFIAVSVIANVVETVPC-GSSPGHIKELPCGERYAVAFFCLDTACV 237

Query: 240 LIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRV 299
           +IFT EYLLRL AAPSR RF+RSVMS+IDVVAILPYYIGL++  N+DVSGAFVTLRVFRV
Sbjct: 238 MIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRV 297

Query: 300 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSI 359
           FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG++ + FTSI
Sbjct: 298 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSI 357

Query: 360 PAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 419
           PAAFWYTIVTMTTLGYGDMVP TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ
Sbjct: 358 PAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 417

Query: 420 RADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLED--SGSGEEQALCVRNRSAFEQQ 477
           RADKRRAQ+K RLARIR AKSG+ NA++Q K+NG L +    S +EQA   ++ S+FE Q
Sbjct: 418 RADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQ 477

Query: 478 HHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGR-TSRSTSVSSQPVGPGSLLSSCCPRR 536
           HHHLLHCLEKTT HEF DE  F E+   V+   R +S S S+SSQ      + S+CC RR
Sbjct: 478 HHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQ----GVTSTCCSRR 533

Query: 537 AKRRAIRLANSTASVS-RGSMQELD--MLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRD 593
            K +  R+ N+  S S +GS+QEL    +  + R+    SRSSLNAK  + + LNC+   
Sbjct: 534 HK-KTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPY 592

Query: 594 FVAAIISIPTPPANTPD-ESQPSSPGGGGRAGSTLRNSSL 632
              AIISIPTPP  TP+ + +P SP   G  G+ +R S+L
Sbjct: 593 VTTAIISIPTPPVTTPEGDDRPESPEYSG--GNIVRVSAL 630


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  815 bits (2105), Expect = 0.0
 Identities = 430/659 (65%), Positives = 510/659 (77%), Gaps = 35/659 (5%)

Query: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR 60
           MAAG+A WLPFARAAA+GW+P+A  P+P AP  K  R DE++V+NVSGRRF+TW+ TL+R
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER 60

Query: 61  YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
           YPDTLLGS+EKEFF++ D+ EYFFDRDP++FR VLNFYRTG+LH PR ECI A+D+ELAF
Sbjct: 61  YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF 120

Query: 121 YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDG-PALPAGSSLRQRLWRAFENP 179
           YG++PE++GDCC EEY+DRK+ENAERL +D ++E   +  P+L    S RQ +WRAFENP
Sbjct: 121 YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSL----SFRQTMWRAFENP 176

Query: 180 HTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACV 239
           HTST ALVFYYVTGFFIAVSVI NVVET+PC       S+E PCGER+  AFFC+DTACV
Sbjct: 177 HTSTLALVFYYVTGFFIAVSVITNVVETVPC--GTVPGSKELPCGERYSVAFFCLDTACV 234

Query: 240 LIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRV 299
           +IFT EYLLRLFAAPSR RF+RSVMS+IDVVAI+PYYIGL++  N+DVSGAFVTLRVFRV
Sbjct: 235 MIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRV 294

Query: 300 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSI 359
           FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG++ + FTSI
Sbjct: 295 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSI 354

Query: 360 PAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 419
           PA+FWYTIVTMTTLGYGDMVP TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ
Sbjct: 355 PASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 414

Query: 420 RADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNG----GLEDSGSGEEQALCVRNRSAFE 475
           RADKRRAQ+K RLARIR+AK+G++NA+L  K+NG     LE +G+ EE+ +  +  S  E
Sbjct: 415 RADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHM-GKTTSLIE 473

Query: 476 QQHHHLLHCLEKTTCHEFTDELTFSE-ALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCP 534
            QHHHLLHCLEKTT HEF DE  F +  + +      ++RS S+SS P     L ++CC 
Sbjct: 474 SQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP----GLTTTCCS 529

Query: 535 RRAKRRAIRLANSTASVSR-GSMQELDM--LAGLRRSHAPQSRSSLNAKPHDSLDLNCDS 591
           RR+K +   L NS    +R  SMQEL    + G  +     SRSSLN K  D L  NC +
Sbjct: 530 RRSK-KTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKT 588

Query: 592 RDFVAAIISIPTPPANTPD-ESQ--PSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL 647
                AIISIPTPPA TP+ ES+  P+SPG            +   P +    VK+S+L
Sbjct: 589 SQITTAIISIPTPPALTPEGESRPPPASPG-----------PNTNIPSIASNVVKVSAL 636


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  803 bits (2075), Expect = 0.0
 Identities = 430/678 (63%), Positives = 510/678 (75%), Gaps = 54/678 (7%)

Query: 1   MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDR 60
           MAAG+A WLPFARAAA+GW+P+A  P+P AP  K  R DE++V+NVSGRRF+TW+ TL+R
Sbjct: 1   MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER 60

Query: 61  YPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAF 120
           YPDTLLGS+EKEFF++ D+ EYFFDRDP++FR VLNFYRTG+LH PR ECI A+D+ELAF
Sbjct: 61  YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF 120

Query: 121 YGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDG-PALPAGSSLRQRLWRAFENP 179
           YG++PE++GDCC EEY+DRK+ENAERL +D ++E   +  P+L    S RQ +WRAFENP
Sbjct: 121 YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSL----SFRQTMWRAFENP 176

Query: 180 HTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACV 239
           HTST ALVFYYVTGFFIAVSVI NVVET+PC       S+E PCGER+  AFFC+DTACV
Sbjct: 177 HTSTLALVFYYVTGFFIAVSVITNVVETVPC--GTVPGSKELPCGERYSVAFFCLDTACV 234

Query: 240 LIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRV 299
           +IFT EYLLRLFAAPSR RF+RSVMS+IDVVAI+PYYIGL++  N+DVSGAFVTLRVFRV
Sbjct: 235 MIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRV 294

Query: 300 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSI 359
           FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG++ + FTSI
Sbjct: 295 FRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSI 354

Query: 360 PAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 419
           PA+FWYTIVTMTTLGYGDMVP TIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ
Sbjct: 355 PASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQ 414

Query: 420 RADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNG----GLEDSGSGEEQALCVRNRSAFE 475
           RADKRRAQ+K RLARIR+AK+G++NA+L  K+NG     LE +G+ EE+ +  +  S  E
Sbjct: 415 RADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHM-GKTTSLIE 473

Query: 476 QQHHHLLHCLEKTT-------------------CHEFTDELTFSE-ALGAVSPGGRTSRS 515
            QHHHLLHCLEKTT                    HEF DE  F +  + +      ++RS
Sbjct: 474 SQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRS 533

Query: 516 TSVSSQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSR-GSMQELDM--LAGLRRSHAPQ 572
            S+SS P     L ++CC RR+K +   L NS    +R  SMQEL    + G  +     
Sbjct: 534 PSLSSHP----GLTTTCCSRRSK-KTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTT 588

Query: 573 SRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPD-ESQ--PSSPGGGGRAGSTLRN 629
           SRSSLN K  D L  NC +     AIISIPTPPA TP+ ES+  P+SPG           
Sbjct: 589 SRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPG----------- 637

Query: 630 SSLGTPCLFPETVKISSL 647
            +   P +    VK+S+L
Sbjct: 638 PNTNIPSIASNVVKVSAL 655


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  279 bits (713), Expect = 7e-75
 Identities = 156/418 (37%), Positives = 237/418 (56%), Gaps = 26/418 (6%)

Query: 27  LPPAPG--VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA------- 77
           LPP P   V++      + +NV G   E    TLDR P T LG       +D+       
Sbjct: 16  LPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDD 75

Query: 78  ---DSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLE 134
              D  EYFFDR P  F  +LNFYRTGRLH   + C  +F +EL ++G+    +  CC  
Sbjct: 76  YSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQA 135

Query: 135 EYRDRKKENAERLAEDEEA--EQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVT 192
            Y  +K++  E L  + E   E+ G+       +  R++LW   E P++S AA +   ++
Sbjct: 136 RYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIIS 195

Query: 193 GFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFA 252
             FI +S IA  + T+P      +S  E       PQ    ++  C+  FT EYLLR  +
Sbjct: 196 IMFIVLSTIALSLNTLP----ELQSLDEFGQSTDNPQLAH-VEAVCIAWFTMEYLLRFLS 250

Query: 253 APSRCRFLRSVMSLIDVVAILPYYIGLLVPKND-------DVSGAFVTLRVFRVFRIFKF 305
           +P + +F +  ++ ID++AILPYY+ + + +++       +V       R+ R+ RI K 
Sbjct: 251 SPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKL 310

Query: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWY 365
           +RHS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK  + T F SIPA+FW+
Sbjct: 311 ARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWW 370

Query: 366 TIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 423
             +TMTT+GYGD+ P T+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K
Sbjct: 371 ATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 428


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  279 bits (713), Expect = 7e-75
 Identities = 151/418 (36%), Positives = 239/418 (57%), Gaps = 26/418 (6%)

Query: 27  LPPAPG--VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF----- 74
           LPP P   +++      + +NV G   E    TLDR P T LG     ++ +        
Sbjct: 20  LPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDD 79

Query: 75  YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLE 134
           Y+ +  EYFFDR P  F  +LNFYRTG+LH   + C  +F +EL ++G+    +  CC  
Sbjct: 80  YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139

Query: 135 EYRDRKKENAERLAEDEEAEQAGDGPALP--AGSSLRQRLWRAFENPHTSTAALVFYYVT 192
            Y  +K++  E L  + E  +  +G           R++LW   E P++S AA +   V+
Sbjct: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVS 199

Query: 193 GFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFA 252
             FI +S IA  + T+P     + +       +    A   ++  C+  FT EYLLR  +
Sbjct: 200 ILFIVLSTIALSLNTLP---ELQETDEFGQLNDNRQLAH--VEAVCIAWFTMEYLLRFLS 254

Query: 253 APSRCRFLRSVMSLIDVVAILPYYIGLLVPKND-------DVSGAFVTLRVFRVFRIFKF 305
           +P++ +F +  +++ID++AILPYY+ + + +++       +V       R+ R+ RI K 
Sbjct: 255 SPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKL 314

Query: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWY 365
           +RHS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK  + T FTSIPA+FW+
Sbjct: 315 ARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWW 374

Query: 366 TIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 423
             +TMTT+GYGD+ P T+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K
Sbjct: 375 ATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 432


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  278 bits (711), Expect = 1e-74
 Identities = 181/494 (36%), Positives = 269/494 (54%), Gaps = 65/494 (13%)

Query: 25  QPLPP---APGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSG 80
           +PLPP   A G +   G+ V V+N+SG RFET   TL ++P+TLLG  ++   ++D    
Sbjct: 87  EPLPPSLPAAGEQDCCGERV-VINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRN 145

Query: 81  EYFFDRDPDMFRHVLNFYRTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDR 139
           EYFFDR+   F  +L +Y++G R+  P    I  F EE+ FY L     G+  +E++R  
Sbjct: 146 EYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQL-----GEEAMEKFR-- 198

Query: 140 KKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVS 199
                    EDE   +  + P LP     RQ +W  FE P +S  A     V+   I +S
Sbjct: 199 ---------EDEGFLREEERP-LPRRDFQRQ-VWLLFEYPESSGPARGIAIVSVLVILIS 247

Query: 200 VIANVVETIP----------------CRGSARRSSREQPCGERFPQAFFCMDTACVLIFT 243
           ++   +ET+P                   +   +S  +     F   FF ++T C++ F+
Sbjct: 248 IVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFS 307

Query: 244 GEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGL---LVPKNDDVSGAFV-----TLR 295
            E L+R FA PS+  F R++M+LID+VAI+PY+I L   L  +  +   A        +R
Sbjct: 308 FELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIR 367

Query: 296 VFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTN 355
           + RVFRIFK SRHS+GL+ILG TLK+   ELG L+F L + +I+F++ +++AE     + 
Sbjct: 368 LVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSG 427

Query: 356 FTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIY 415
           F+SIP AFW+ +VTMTT+GYGDM P TI GKI GS+C+++GVL IALPVPVIVSNF+  Y
Sbjct: 428 FSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487

Query: 416 HQNQRADKRRAQQKV--------RLARIRLAKSGTTNAFLQYK--QNGGLEDSG------ 459
           H+    +++     V            +R A+S +T +  +Y   + GG+  S       
Sbjct: 488 HRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPF 547

Query: 460 -SGEEQALCVRNRS 472
            +G   A C  N +
Sbjct: 548 KTGNSTATCTTNNN 561


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  275 bits (703), Expect = 9e-74
 Identities = 160/415 (38%), Positives = 242/415 (58%), Gaps = 51/415 (12%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFY 98
           E +V+N+SG RFET   TL ++P+TLLG  +K   ++D    EYFFDR+   F  +L +Y
Sbjct: 33  ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 92

Query: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK---KENAERLAEDEEAE 154
           ++G RL  P    +  F EE+ FY L     G+  +E +R+ +   KE    L E+E   
Sbjct: 93  QSGGRLRRPVNVPLDIFSEEIRFYEL-----GEEAMEMFREDEGYIKEEERPLPENE--- 144

Query: 155 QAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPC---- 210
                         ++++W  FE P +S  A +   V+   I +S+++  +ET+P     
Sbjct: 145 -------------FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDE 191

Query: 211 ----RGSA------RRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFL 260
                GS         S+        F   FF ++T C++ F+ E+L+R FA PS+  F 
Sbjct: 192 NEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFF 251

Query: 261 RSVMSLIDVVAILPYYIGL---LVPKNDDVS--------GAFVTLRVFRVFRIFKFSRHS 309
            ++M++ID+VAI+PY+I L   L  K +D               +R+ RVFRIFK SRHS
Sbjct: 252 TNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHS 311

Query: 310 QGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVT 369
           +GL+ILG TLK+   ELG L+F L + +I+F++ +++AE    ++ F SIP AFW+ +V+
Sbjct: 312 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVS 371

Query: 370 MTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424
           MTT+GYGDMVP+TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 372 MTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 426


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  274 bits (700), Expect = 2e-73
 Identities = 180/451 (39%), Positives = 250/451 (55%), Gaps = 62/451 (13%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFY 98
           E LV+NV+G RFET   TL R+PDTLLG  + +  FYD    EYFFDR    F  VL +Y
Sbjct: 13  ERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYY 72

Query: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAG 157
           ++G RL  P    +  F EE+AFYGL     G   L            RL EDE      
Sbjct: 73  QSGGRLRRPAHVPLDVFLEEVAFYGL-----GAAALA-----------RLREDEGCPVPP 116

Query: 158 DGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-------- 209
           + P LP  +  RQ LW  FE P +S AA V   V+   I VS++   +ET+P        
Sbjct: 117 ERP-LPRRAFARQ-LWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDG 174

Query: 210 ---------------CRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAP 254
                            GS++      P    F   FF ++T C+  F+ E L+RL   P
Sbjct: 175 TGLAAAAAAGPFPAPLNGSSQMPGN--PPRLPFNDPFFVVETLCICWFSFELLVRLLVCP 232

Query: 255 SRCRFLRSVMSLIDVVAILPYYI--GLLVPKNDDVSGAFVTL------RVFRVFRIFKFS 306
           S+  F ++VM+LID VAILPY++  G  + +   V    ++L      R+ RVFRIFK S
Sbjct: 233 SKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLS 292

Query: 307 RHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYT 366
           RHS+GL+ILG TL++   ELG L+F L + +++F++ +++AE     ++FTSIP +FW+ 
Sbjct: 293 RHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWA 352

Query: 367 IVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRA 426
           +VTMTT+GYGDM P T+ GKI GS+C+++GVL I+LPVPVIVSNFS  YH+     +   
Sbjct: 353 VVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHR-----ETEG 407

Query: 427 QQKVRLARIRLAKSGTTNAFLQYKQNGGLED 457
           ++    + + +   G     L+ K NGGL D
Sbjct: 408 EEAGMFSHVDMQPCGP----LEGKANGGLVD 434


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  270 bits (689), Expect = 4e-72
 Identities = 160/406 (39%), Positives = 241/406 (59%), Gaps = 39/406 (9%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFY 98
           E +V+N+SG RFET   TL ++P+TLLG+ +K   ++D    EYFFDR+   F  +L +Y
Sbjct: 37  ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 96

Query: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAG 157
           ++G RL  P    +  F EE+ FY L     G+  +E++R           EDE   +  
Sbjct: 97  QSGGRLRRPVNVPLDMFSEEIKFYEL-----GEEAMEKFR-----------EDEGFIKEE 140

Query: 158 DGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-------C 210
           + P LP     RQ +W  FE P +S  A V   V+   I +S++   +ET+P        
Sbjct: 141 ERP-LPEKEYQRQ-VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDF 198

Query: 211 RGSARRSSREQPC--GERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLID 268
            G+  R            F   FF ++T C++ F+ E ++R FA PS+  F +++M+ ID
Sbjct: 199 TGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258

Query: 269 VVAILPYYIGL---LVPKNDDVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYT 318
           +VAI+PY+I L   +  +  +  G   T       +R+ RVFRIFK SRHS+GL+ILG T
Sbjct: 259 IVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT 318

Query: 319 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDM 378
           LK+   ELG L+F L + +I+F++ +++AE    +++F+SIP AFW+ +V+MTT+GYGDM
Sbjct: 319 LKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDM 378

Query: 379 VPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424
            P TI GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 379 YPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQ 424


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  269 bits (687), Expect = 7e-72
 Identities = 162/451 (35%), Positives = 260/451 (57%), Gaps = 44/451 (9%)

Query: 28  PPAPG-VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFD 85
           PP P  V  + G++ +++N++G RFET   TL ++P+TLLG  EK   F+D+   EYFFD
Sbjct: 73  PPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFD 132

Query: 86  RDPDMFRHVLNFYRTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENA 144
           R+   F  +L +Y++G ++  P    I  F +E++FY L     G   ++++R+      
Sbjct: 133 RNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYEL-----GSEAMDQFRED----- 182

Query: 145 ERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANV 204
           E   +D E         LP     RQ  W  FE P +S+AA     V+   + +S+    
Sbjct: 183 EGFIKDPET-------LLPTNDIHRQ-FWLLFEYPESSSAARAVAVVSVLVVVISITIFC 234

Query: 205 VETIP----------CRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAP 254
           +ET+P           R      S+       F   FF +++ C++ FT E +LR    P
Sbjct: 235 LETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCP 294

Query: 255 SRCRFLRSVMSLIDVVAILPYYIGLLVP--------KNDDVSGAFVTL-RVFRVFRIFKF 305
           S+  F R++M++ID+++I+PY+  L+             ++S A + + R+ RVFRIFK 
Sbjct: 295 SKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKL 354

Query: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWY 365
           SRHS+GL+ILG TLK+   ELG L+F L + +I+F++ +++AE    +++F+SIP  FW+
Sbjct: 355 SRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWW 414

Query: 366 TIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYH-QNQRADKR 424
            +VTMTT+GYGDM P+T  GKI G++C+++GVL IALPVPVIVSNF+  YH + +  +K+
Sbjct: 415 AVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQ 474

Query: 425 RAQQKV-RLARIRLAKSGTTNAFLQYKQNGG 454
               ++ R+     ++ G+T++    K NGG
Sbjct: 475 NIPGEIERILNSVGSRMGSTDSL--NKTNGG 503


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  267 bits (682), Expect = 3e-71
 Identities = 163/460 (35%), Positives = 246/460 (53%), Gaps = 62/460 (13%)

Query: 37  RGDEV--LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDRDPD 89
           +GDE   +V+NV G R +T+++TL   P T L       +   F YD  + E+FFDR P 
Sbjct: 3   QGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPG 62

Query: 90  MFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKENA---- 144
           +F H+LN+YRTG+LHCP   C   ++EELAF+G+    V  CC   YR  R  E A    
Sbjct: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122

Query: 145 -----ERLAEDEEAEQAGDG-------------------PALPAGSSLR--QRLWRAFEN 178
                +  A+D +A+  GD                       P G   R   R+W  FE+
Sbjct: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182

Query: 179 PHTSTAALVFYYVTGFFIAVSVIANVVETIPCRG---------SARRSSREQPCGERFPQ 229
           P++S  A    + + FFI VS+    +ET              + R  ++ +   E   +
Sbjct: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242

Query: 230 AFFC-MDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPK 283
           AF   ++  CV+ FT E+L+R+   P++  F+++ +++ID VAILP+Y+     GL    
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302

Query: 284 NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATV 343
             DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+
Sbjct: 303 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 362

Query: 344 MFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSL 394
           ++YAE+          +  T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L
Sbjct: 363 IYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCAL 422

Query: 395 SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLAR 434
           +GVL IA+PVPVIV+NF   Y       K   ++K  + R
Sbjct: 423 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  267 bits (682), Expect = 3e-71
 Identities = 163/460 (35%), Positives = 246/460 (53%), Gaps = 62/460 (13%)

Query: 37  RGDEV--LVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFFYDADSGEYFFDRDPD 89
           +GDE   +V+NV G R +T+++TL   P T L       +   F YD  + E+FFDR P 
Sbjct: 3   QGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPG 62

Query: 90  MFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKENA---- 144
           +F H+LN+YRTG+LHCP   C   ++EELAF+G+    V  CC   YR  R  E A    
Sbjct: 63  VFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122

Query: 145 -----ERLAEDEEAEQAGDG-------------------PALPAGSSLR--QRLWRAFEN 178
                +  A+D +A+  GD                       P G   R   R+W  FE+
Sbjct: 123 GGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFED 182

Query: 179 PHTSTAALVFYYVTGFFIAVSVIANVVETIPCRG---------SARRSSREQPCGERFPQ 229
           P++S  A    + + FFI VS+    +ET              + R  ++ +   E   +
Sbjct: 183 PYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETE 242

Query: 230 AFFC-MDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPK 283
           AF   ++  CV+ FT E+L+R+   P++  F+++ +++ID VAILP+Y+     GL    
Sbjct: 243 AFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKA 302

Query: 284 NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATV 343
             DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+
Sbjct: 303 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATM 362

Query: 344 MFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSL 394
           ++YAE+          +  T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L
Sbjct: 363 IYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCAL 422

Query: 395 SGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLAR 434
           +GVL IA+PVPVIV+NF   Y       K   ++K  + R
Sbjct: 423 AGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPR 462


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  266 bits (679), Expect = 6e-71
 Identities = 160/418 (38%), Positives = 238/418 (56%), Gaps = 50/418 (11%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFY 98
           E +V+NVSG RFET   TL ++P+TLLG  EK   ++D    EYFFDR+   F  +L +Y
Sbjct: 176 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY 235

Query: 99  RTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAG 157
           ++G RL  P       F EE+ FY L     G+  L ++R           EDE   +  
Sbjct: 236 QSGGRLKRPVNVPFDIFTEEVKFYQL-----GEEALLKFR-----------EDEGFVREE 279

Query: 158 DGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRS 217
           +  ALP  +  ++++W  FE P +S+ A     V+   I +S++   +ET+P     R  
Sbjct: 280 EDRALPE-NEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDL 338

Query: 218 SREQPCGER-------------------FPQAFFCMDTACVLIFTGEYLLRLFAAPSRCR 258
                 G                     F   FF ++T C++ F+ E+++R FA PS+  
Sbjct: 339 VMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQAL 398

Query: 259 FLRSVMSLIDVVAILPYYIGLLVPKNDDVSG---------AFVTLRVFR---VFRIFKFS 306
           F +++M++ID+V+ILPY+I L         G         +F  LR+ R   VFRIFK S
Sbjct: 399 FFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLS 458

Query: 307 RHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYT 366
           RHS+GL+ILG+TL++   ELG L+F L + +I+F++ +++AE     T+F SIP AFW+ 
Sbjct: 459 RHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWA 518

Query: 367 IVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424
           +VTMTT+GYGDM P T+ GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 519 VVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQ 576


>gi|25952087 potassium voltage-gated channel, shaker-related
           subfamily, member 5 [Homo sapiens]
          Length = 613

 Score =  264 bits (675), Expect = 2e-70
 Identities = 163/420 (38%), Positives = 229/420 (54%), Gaps = 64/420 (15%)

Query: 44  VNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDRDPDMFRHVLNFYRTG- 101
           +N+SG RFET   TL ++P+TLLG   K   ++D    EYFFDR+   F  +L +Y++G 
Sbjct: 124 INISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGG 183

Query: 102 RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPA 161
           RL  P    +  F +E+ FY L     GD  +E +R           EDE   +  + P 
Sbjct: 184 RLRRPVNVSLDVFADEIRFYQL-----GDEAMERFR-----------EDEGFIKEEEKP- 226

Query: 162 LPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQ 221
           LP     RQ +W  FE P +S +A     V+   I +S+I   +ET+P     R   R  
Sbjct: 227 LPRNEFQRQ-VWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHP 285

Query: 222 PCGERFP-----------------------------QAFFCMDTACVLIFTGEYLLRLFA 252
           P   + P                               FF ++T CV+ FT E L+R FA
Sbjct: 286 PAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFA 345

Query: 253 APSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGA---------------FVTLRVF 297
            PS+  F R++M++IDVVAI PY+I L     +   G                   +R+ 
Sbjct: 346 CPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLV 405

Query: 298 RVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFT 357
           RVFRIFK SRHS+GL+ILG TL++   ELG L+F L + +I+F++ +++AE     T+F+
Sbjct: 406 RVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFS 465

Query: 358 SIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 417
           SIP AFW+ +VTMTT+GYGDM P T+ GKI GS+C+++GVL IALPVPVIVSNF+  YH+
Sbjct: 466 SIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHR 525


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  264 bits (675), Expect = 2e-70
 Identities = 166/467 (35%), Positives = 243/467 (52%), Gaps = 71/467 (15%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLL---------GSSEKEFFYDADSG-------EYF 83
           E +++NV G R ET+++TL   P T L         G  E +      SG       E+F
Sbjct: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95

Query: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKE 142
           FDR P +F +VLN+YRTG+LHCP   C   F+EEL F+G+    V  CC   YR  R  E
Sbjct: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAE 155

Query: 143 NAERLAEDEEAEQAGDGPALPAGSSLRQ---------------------------RLWRA 175
            A  + E  +   +G GP+  AG   R+                           R+W  
Sbjct: 156 EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWAL 215

Query: 176 FENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAF---- 231
           FE+P++S AA V  + + FFI VS+    +ET       R  +     G      F    
Sbjct: 216 FEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREV 275

Query: 232 ------FCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLL 280
                   ++  CVL FT E+L+R+   P    F+++++++ID VAILP+Y+     GL 
Sbjct: 276 ETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLS 335

Query: 281 VPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIF 340
                DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IF
Sbjct: 336 SKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 395

Query: 341 ATVMFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391
           AT+++YAE+         G + T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++
Sbjct: 396 ATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGAL 455

Query: 392 CSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQQKVRLARI 435
           C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++
Sbjct: 456 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL 502


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  264 bits (675), Expect = 2e-70
 Identities = 166/467 (35%), Positives = 243/467 (52%), Gaps = 71/467 (15%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLL---------GSSEKEFFYDADSG-------EYF 83
           E +++NV G R ET+++TL   P T L         G  E +      SG       E+F
Sbjct: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95

Query: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKE 142
           FDR P +F +VLN+YRTG+LHCP   C   F+EEL F+G+    V  CC   YR  R  E
Sbjct: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAE 155

Query: 143 NAERLAEDEEAEQAGDGPALPAGSSLRQ---------------------------RLWRA 175
            A  + E  +   +G GP+  AG   R+                           R+W  
Sbjct: 156 EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWAL 215

Query: 176 FENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAF---- 231
           FE+P++S AA V  + + FFI VS+    +ET       R  +     G      F    
Sbjct: 216 FEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREV 275

Query: 232 ------FCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLL 280
                   ++  CVL FT E+L+R+   P    F+++++++ID VAILP+Y+     GL 
Sbjct: 276 ETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLS 335

Query: 281 VPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIF 340
                DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IF
Sbjct: 336 SKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 395

Query: 341 ATVMFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391
           AT+++YAE+         G + T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++
Sbjct: 396 ATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGAL 455

Query: 392 CSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQQKVRLARI 435
           C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++
Sbjct: 456 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL 502


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  264 bits (675), Expect = 2e-70
 Identities = 166/467 (35%), Positives = 243/467 (52%), Gaps = 71/467 (15%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLL---------GSSEKEFFYDADSG-------EYF 83
           E +++NV G R ET+++TL   P T L         G  E +      SG       E+F
Sbjct: 36  EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFF 95

Query: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD-RKKE 142
           FDR P +F +VLN+YRTG+LHCP   C   F+EEL F+G+    V  CC   YR  R  E
Sbjct: 96  FDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAE 155

Query: 143 NAERLAEDEEAEQAGDGPALPAGSSLRQ---------------------------RLWRA 175
            A  + E  +   +G GP+  AG   R+                           R+W  
Sbjct: 156 EALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWAL 215

Query: 176 FENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAF---- 231
           FE+P++S AA V  + + FFI VS+    +ET       R  +     G      F    
Sbjct: 216 FEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREV 275

Query: 232 ------FCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLL 280
                   ++  CVL FT E+L+R+   P    F+++++++ID VAILP+Y+     GL 
Sbjct: 276 ETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLS 335

Query: 281 VPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIF 340
                DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IF
Sbjct: 336 SKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIF 395

Query: 341 ATVMFYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391
           AT+++YAE+         G + T+F +IP  FW+ +VTMTTLGYGDM P T +G + G++
Sbjct: 396 ATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGAL 455

Query: 392 CSLSGVLVIALPVPVIVSNFSRIYH---QNQRADKRRAQQKVRLARI 435
           C+L+GVL IA+PVPVIV+NF   Y      Q+  K+R +   R A++
Sbjct: 456 CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL 502


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  261 bits (668), Expect = 1e-69
 Identities = 171/482 (35%), Positives = 244/482 (50%), Gaps = 93/482 (19%)

Query: 25  QPLPPAPGVKASR-----GDE-VLVVNVSGRRFETWKNTLDRYPDT-LLGSSEKE----F 73
           +P P  P     R     GD   +V+NV G R ET+++TL   P T L G +E E    F
Sbjct: 67  EPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF 126

Query: 74  FYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCL 133
            YD  + E+FFDR P +F +VLN+YRTG+LHCP   C   F+EEL F+G+    V  CC 
Sbjct: 127 DYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCW 186

Query: 134 EEYRDRKKE----------------NAERLAE------DEEA------------------ 153
             YR  +                  NA   A       D+EA                  
Sbjct: 187 MTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLC 246

Query: 154 -EQAGDGPALPAGSS----------LRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIA 202
            + AG G   P G +           + R+W  FE+P++S AA    + + FFI +S+  
Sbjct: 247 FQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITT 306

Query: 203 NVVETIPCRGSARRSSREQPCGERFPQA---------------FFCMDTACVLIFTGEYL 247
             +ET    G    S++        P A                  ++  CV+ FT E+L
Sbjct: 307 FCLETH--EGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFL 364

Query: 248 LRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKNDDVSGAFVTLRVFRVFRI 302
           +R+   P +  FL+S +++ID VAILP+Y+     GL      DV G    +R  R+ RI
Sbjct: 365 MRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRI 424

Query: 303 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK---------GTNK 353
           FK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT+++YAE+         G+N 
Sbjct: 425 FKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNH 484

Query: 354 TNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSR 413
           T F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L+GVL IA+PVPVIV+NF  
Sbjct: 485 TYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGM 544

Query: 414 IY 415
            Y
Sbjct: 545 YY 546


>gi|4504821 potassium voltage-gated channel, shaker-related
           subfamily, member 6 [Homo sapiens]
          Length = 529

 Score =  256 bits (653), Expect = 6e-68
 Identities = 171/462 (37%), Positives = 236/462 (51%), Gaps = 81/462 (17%)

Query: 28  PPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEF-FYDADSGEYFFDR 86
           P A G       E LV+N+SG RFET   TL  +PDTLLG   +   F+D    EYFFDR
Sbjct: 29  PEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDR 88

Query: 87  DPDMFRHVLNFYRTG-RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAE 145
           +   F  +L +Y++G RL  P    +  F EE+ FY L     GD  L  +R        
Sbjct: 89  NRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQL-----GDEALAAFR-------- 135

Query: 146 RLAEDEEAEQAGDGPALPAGSSLRQR-LWRAFENPHTSTAALVFYYVTGFFIAVSVIANV 204
              EDE     G     P  S   QR +W  FE P +S  A     V+   I +S++   
Sbjct: 136 ---EDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFC 192

Query: 205 VETIP--------------------CRGSARRSSREQPC--------------------- 223
           +ET+P                     RGS      E                        
Sbjct: 193 LETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLS 252

Query: 224 ---GERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGL- 279
              G  F   FF ++T C++ FT E L+R  A PS+  F R++M++ID+VAI PY+I L 
Sbjct: 253 TLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLG 312

Query: 280 --LVPKNDD--VSGA-------------FVTLRVFRVFRIFKFSRHSQGLRILGYTLKSC 322
             LV + +    SG                 +R+ RVFRIFK SRHS+GL+ILG TL++ 
Sbjct: 313 TELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQAS 372

Query: 323 ASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPST 382
             ELG L+F L + +I+F++ +++AE   + + F SIP AFW+ +VTMTT+GYGDM P T
Sbjct: 373 MRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMT 432

Query: 383 IAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKR 424
           + GKI GS+C+++GVL IALPVPVIVSNF+  YH+    +++
Sbjct: 433 VGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQ 474


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  251 bits (642), Expect = 1e-66
 Identities = 151/438 (34%), Positives = 226/438 (51%), Gaps = 46/438 (10%)

Query: 81  EYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140
           E+FFDR P +F +VLN+YRTG+LHCP   C   F+EELAF+G+    V  CC   YR  +
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160

Query: 141 KEN-----------------------AERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFE 177
                                     A+RL  ++ A   G          L+ R+W  FE
Sbjct: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFE 220

Query: 178 NPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERF--------PQ 229
           +P++S AA    + + FFI VS+    +ET       +  +     G             
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP 280

Query: 230 AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKN 284
           A   ++  CV+ FT E+L+R+  +P++  F+++++++ID VAILP+Y+     GL     
Sbjct: 281 ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340

Query: 285 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
            DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 341 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400

Query: 345 FYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLS 395
           +YAE+          +  T F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L+
Sbjct: 401 YYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 460

Query: 396 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGT-TNAFLQYKQNGG 454
           GVL IA+PVPVIV+NF   Y       K   ++K  +     A S T     L    N  
Sbjct: 461 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNST 520

Query: 455 LEDSGSGEEQALCVRNRS 472
             D+  G++  L   NRS
Sbjct: 521 QSDTCLGKDNRLLEHNRS 538



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 3/35 (8%)

Query: 39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSE 70
          +E +++NV G R ET+++TL   P T   LL SSE
Sbjct: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  251 bits (642), Expect = 1e-66
 Identities = 151/438 (34%), Positives = 226/438 (51%), Gaps = 46/438 (10%)

Query: 81  EYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140
           E+FFDR P +F +VLN+YRTG+LHCP   C   F+EELAF+G+    V  CC   YR  +
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160

Query: 141 KEN-----------------------AERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFE 177
                                     A+RL  ++ A   G          L+ R+W  FE
Sbjct: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFE 220

Query: 178 NPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERF--------PQ 229
           +P++S AA    + + FFI VS+    +ET       +  +     G             
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP 280

Query: 230 AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKN 284
           A   ++  CV+ FT E+L+R+  +P++  F+++++++ID VAILP+Y+     GL     
Sbjct: 281 ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340

Query: 285 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
            DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 341 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400

Query: 345 FYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLS 395
           +YAE+          +  T F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L+
Sbjct: 401 YYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 460

Query: 396 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGT-TNAFLQYKQNGG 454
           GVL IA+PVPVIV+NF   Y       K   ++K  +     A S T     L    N  
Sbjct: 461 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNST 520

Query: 455 LEDSGSGEEQALCVRNRS 472
             D+  G++  L   NRS
Sbjct: 521 QSDTCLGKDNRLLEHNRS 538



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 3/35 (8%)

Query: 39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSE 70
          +E +++NV G R ET+++TL   P T   LL SSE
Sbjct: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  251 bits (642), Expect = 1e-66
 Identities = 151/438 (34%), Positives = 226/438 (51%), Gaps = 46/438 (10%)

Query: 81  EYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK 140
           E+FFDR P +F +VLN+YRTG+LHCP   C   F+EELAF+G+    V  CC   YR  +
Sbjct: 101 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHR 160

Query: 141 KEN-----------------------AERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFE 177
                                     A+RL  ++ A   G          L+ R+W  FE
Sbjct: 161 DAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFE 220

Query: 178 NPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERF--------PQ 229
           +P++S AA    + + FFI VS+    +ET       +  +     G             
Sbjct: 221 DPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDP 280

Query: 230 AFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYI-----GLLVPKN 284
           A   ++  CV+ FT E+L+R+  +P++  F+++++++ID VAILP+Y+     GL     
Sbjct: 281 ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAA 340

Query: 285 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVM 344
            DV G    +R  R+ RIFK +RH  GLR+LG+TL++  +E   L+  L + ++IFAT++
Sbjct: 341 KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMI 400

Query: 345 FYAEK---------GTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLS 395
           +YAE+          +  T F +IP  FW+ +VTMTTLGYGDM P T +G + G++C+L+
Sbjct: 401 YYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALA 460

Query: 396 GVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGT-TNAFLQYKQNGG 454
           GVL IA+PVPVIV+NF   Y       K   ++K  +     A S T     L    N  
Sbjct: 461 GVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNST 520

Query: 455 LEDSGSGEEQALCVRNRS 472
             D+  G++  L   NRS
Sbjct: 521 QSDTCLGKDNRLLEHNRS 538



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 3/35 (8%)

Query: 39 DEVLVVNVSGRRFETWKNTLDRYPDT---LLGSSE 70
          +E +++NV G R ET+++TL   P T   LL SSE
Sbjct: 7  NERVILNVGGTRHETYRSTLKTLPGTRLALLASSE 41


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  251 bits (640), Expect = 2e-66
 Identities = 162/450 (36%), Positives = 236/450 (52%), Gaps = 66/450 (14%)

Query: 40  EVLVVNVSGRRFETWKNTLDRYPDTLLGS------------------SEKEFFYDAD--S 79
           +   VNV G RF   +  L  +P T LG                   S  E   DA+   
Sbjct: 39  DCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVD 98

Query: 80  GEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDR 139
            EYFFDR    FR+VL++YRTGRLH   Q C  +F +E+ ++G+    +  CC + Y  R
Sbjct: 99  NEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYF-R 157

Query: 140 KKENAERL-----AEDEEAEQAGD-----GPALPAGSSLRQRLWRAFENPHTSTAALVFY 189
           +KE +E L      ED+E++   +     GP      ++RQ+LW   E P +STAA +F 
Sbjct: 158 RKELSETLDFKKDTEDQESQHESEQDFSQGPC----PTVRQKLWNILEKPGSSTAARIFG 213

Query: 190 YVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLR 249
            ++  F+ VS+I   +       SA  S  +        Q    ++  C+  FTGE++LR
Sbjct: 214 VISIIFVVVSIINMALM------SAELSWLDL-------QLLEILEYVCISWFTGEFVLR 260

Query: 250 LFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVT------------LRVF 297
                 RCRFLR V ++ID++AILP+YI LLV   + +SG+  T            LR+ 
Sbjct: 261 FLCVRDRCRFLRKVPNIIDLLAILPFYITLLV---ESLSGSQTTQELENVGRIVQVLRLL 317

Query: 298 RVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFT 357
           R  R+ K  RHS GLR LG T+  C  E+G LL  L++ I IF+TV ++AE+    T FT
Sbjct: 318 RALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFT 377

Query: 358 SIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 417
           S+P A+W+   +MTT+GYGD+ P T  GKI   +C LSG+LV+ALP+ +I   FS  Y  
Sbjct: 378 SVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYF- 436

Query: 418 NQRADKRRAQQKVRLARIRLAKSGTTNAFL 447
                 + A  + R A  +L K+  T++++
Sbjct: 437 --TLKLKEAAVRQREALKKLTKNIATDSYI 464


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  239 bits (609), Expect = 8e-63
 Identities = 139/420 (33%), Positives = 230/420 (54%), Gaps = 39/420 (9%)

Query: 34  KASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGS-----SEKEFF-----YDADSGEYF 83
           +  + +E++ +NV G +    ++TL R+P T LG      SE+        Y     EY+
Sbjct: 9   RPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYY 68

Query: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
           FDR+P +FR+VLNFY TG+LH   + C+ +F +E+ ++G+    +  CC   Y++RK+EN
Sbjct: 69  FDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEEN 128

Query: 144 AERLAEDEEAEQAGDGPALPAG--------------SSLRQRLWRAFENPHTSTAALVFY 189
            E+  + +  + + D     +                 LR+++W   ENP         Y
Sbjct: 129 HEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPA--------Y 180

Query: 190 YVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLR 249
            ++   IA+S ++ V+ +I        S  +   GE        ++ AC+  FTGE  +R
Sbjct: 181 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR 240

Query: 250 LFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVS------GAFVT-LRVFRVFRI 302
           L AAP + +F ++ +++ID V+I+P+Y  L V   ++ S      G  V  LR+ R+FRI
Sbjct: 241 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI 300

Query: 303 FKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAA 362
            K +RHS GLR LG TL+    E+G LL  L++ I IF+ +++  EK  + ++ TSIP  
Sbjct: 301 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC 360

Query: 363 FWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 422
           +W+  ++MTT+GYGD  P T+AGK+  S C + G+LV+ALP+ +I + FS+ Y + +  D
Sbjct: 361 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID 420


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  236 bits (603), Expect = 4e-62
 Identities = 158/460 (34%), Positives = 232/460 (50%), Gaps = 44/460 (9%)

Query: 8   WLPFARAAAVGWLPLAQQPLP---PAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDT 64
           +LP  +A    +   AQ+  P   P  G +       +++NV G ++     TLD +P T
Sbjct: 28  FLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLT 87

Query: 65  LLGSSEK--EFF--------YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAF 114
            LG  +    F         YD    E+FFDR+P  F  +L F R G+L   R+ C  +F
Sbjct: 88  RLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSF 147

Query: 115 DEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAE------QAGDGPALPAGSSL 168
            EEL ++G+  + +  CC   Y  + +E AE +  +EE +      +  +GPA   G   
Sbjct: 148 QEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLG 207

Query: 169 R--QRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGER 226
           R  +RL    E PH+     VF  ++  F+ V+ +   V T+P   S R    +  C + 
Sbjct: 208 RCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLP---SLREEEEQGHCSQM 264

Query: 227 FPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKN-- 284
               F  +++ CV  F+ E+LLRL  APS+  FLRS ++LID+VAILPYYI LLV     
Sbjct: 265 CHNVFI-VESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAA 323

Query: 285 ------------DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFS 332
                       D V      LR  R+  + + +RHS GL+ LG T + C  E G LL  
Sbjct: 324 GRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLF 383

Query: 333 LTMAIIIFATVMFYAEKG-TNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391
           L +AI +FA +++  E    +   FTSIPA +W+ ++TMTT+GYGDMVP +  G++    
Sbjct: 384 LCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALS 443

Query: 392 CSLSGVLVIALPVPVIVSNFSRIY----HQNQRADKRRAQ 427
             LSG+L++A PV  I   FSR Y     + +R   RRAQ
Sbjct: 444 SILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQ 483


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  235 bits (599), Expect = 1e-61
 Identities = 155/473 (32%), Positives = 236/473 (49%), Gaps = 39/473 (8%)

Query: 25  QPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYP-------------DTLLGSSEK 71
           +P P +PG         +++NV G R       L R P             D LL   + 
Sbjct: 2   EPWPCSPGGGGGTRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDD 61

Query: 72  EFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDC 131
              YD    E+FFDR P  FR ++   R G+L   R  C  AF +ELA++G+    +  C
Sbjct: 62  ---YDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERC 118

Query: 132 CLEEYRDRKKENAE-RLAEDEEAEQAGDGPALPAGSSL---RQRLWRAFENPHTSTAALV 187
           CL   R R++E AE R    E   Q     AL     L   R+RL    +NPH+  A  +
Sbjct: 119 CLRRLRRREEEAAEARAGPTERGAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKL 178

Query: 188 FYYVTGFFIAVSVIANVVETIP-CRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEY 246
           F  V+  F+AV+ +   + T+P  R    R      C     ++ F ++T CV  F+ E+
Sbjct: 179 FACVSVSFVAVTAVGLCLSTMPDIRAEEERGECSPKC-----RSLFVLETVCVAWFSFEF 233

Query: 247 LLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVT---------LRVF 297
           LLR   A S+C FLR+ +++ID++A+LP+Y+ LL+       G  +          LR  
Sbjct: 234 LLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRAL 293

Query: 298 RVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTN-KTNF 356
           RV  + + +RHS GLR LG T++ CA E G LL  L +A+ +FA ++  AE+    + +F
Sbjct: 294 RVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDF 353

Query: 357 TSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYH 416
           +S+PA++W+ +++MTT+GYGDMVP ++ G++      LSG+L++A PV  I   FSR Y 
Sbjct: 354 SSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYS 413

Query: 417 QNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVR 469
           + +   +R A  +  L       +  T    Q   + GL D  +    AL VR
Sbjct: 414 ELKEQQQRAASPEPALQEDSTHSATATEDSSQGPDSAGLADDSA---DALWVR 463


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  233 bits (594), Expect = 4e-61
 Identities = 158/467 (33%), Positives = 238/467 (50%), Gaps = 40/467 (8%)

Query: 29  PAPGVKASRG--DEVLVVNVSGRRFETWKNTLDRYPDT--------LLGSSEKEFF---- 74
           P PG ++S    D  +VVNV G R   + + L +YP+T        L G  +  F     
Sbjct: 10  PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDD 69

Query: 75  YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCC-- 132
           YD    E++FDRDPD F+ V+  Y  G +H  +  C   F  E+ F+ +  + + DCC  
Sbjct: 70  YDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKS 129

Query: 133 -LEEYRDRKKENAER--LAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFY 189
            L E R+  +E A R  L  D+    A +G         ++ +W+  E P +S  A V  
Sbjct: 130 HLSEKREELEEIARRVQLILDDLGVDAAEG----RWRRCQKCVWKFLEKPESSCPARVVA 185

Query: 190 YVTGFFIAVSVIANVVETIPCRG--SARRSSREQPCGERFPQAFFCMDTACVLIFTGEYL 247
            ++   I VS +   + TIP      A  +  E P  E        ++TAC+  FT EYL
Sbjct: 186 VLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLEN-------VETACIGWFTLEYL 238

Query: 248 LRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVP-------KNDDVSGAFVTLRVFRVF 300
           LRLF++P++  F  S M+++DV+AILP+Y+ L +        +  +V  A   LR+ R+ 
Sbjct: 239 LRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIA 298

Query: 301 RIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIP 360
           RIFK +RHS GL+ L Y LK    ELG LL  L + I +F+ + +  E+   +T F SIP
Sbjct: 299 RIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIP 358

Query: 361 AAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQR 420
            +FW+ I+TMTT+GYGD+ P T  GK+  +I  L GV+ IALP+  I++NF R Y+  QR
Sbjct: 359 QSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVR-YYNKQR 417

Query: 421 ADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALC 467
             +  A+ ++ L  +  +  G             L    +G+E   C
Sbjct: 418 VLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSC 464


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  226 bits (576), Expect = 5e-59
 Identities = 148/432 (34%), Positives = 218/432 (50%), Gaps = 43/432 (9%)

Query: 29  PAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF-----YDAD 78
           P  G++  R DE L VNV G R +     L R+P T LG     +SE++       YD  
Sbjct: 39  PDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEA 98

Query: 79  SGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRD 138
           + E++FDR P  F  +L+FYRTG LH   + C+ AF +E  ++GL    +  CC   Y +
Sbjct: 99  AREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLE 158

Query: 139 RKKENAERLAEDEEAEQAGDG---------------PALPAGSSLRQRLWRAFENPHTST 183
           R+        ED +   + D                 A   G  LR+RLW   ENP  S 
Sbjct: 159 RRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGR-LRRRLWLTMENPGYSL 217

Query: 184 AALVFYYVTGFFIAVSVIANVVETIP-------CRGSARRSSREQPCGERFPQAFFCMDT 236
            + +F  V+   +  S+ A  + ++P           A  ++   P G R       ++ 
Sbjct: 218 PSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEY 277

Query: 237 ACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLL--VPKNDDVSGAFVTL 294
            C+  F+ E   RL  APS   F    ++LID+V++LP+Y+ LL  V   D     F  L
Sbjct: 278 FCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHL 337

Query: 295 -------RVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYA 347
                  R+ R+FR+ K +RHS GLR LG TLK    E+G LL  L + + +F+ V + A
Sbjct: 338 GKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTA 397

Query: 348 EKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVI 407
           EK  +   F +IPA +W+  V+MTT+GYGD+VP T+AGK+  S C L G+LV+ALP+ +I
Sbjct: 398 EKEED-VGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456

Query: 408 VSNFSRIYHQNQ 419
            + FS  Y + +
Sbjct: 457 FNKFSHFYRRQK 468


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  218 bits (556), Expect = 1e-56
 Identities = 140/424 (33%), Positives = 226/424 (53%), Gaps = 45/424 (10%)

Query: 34  KASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGS-----SEKEFF-----YDADSGEYF 83
           +A+  D  + +NV G +     +TL R+P+T LG      S +        YD    E++
Sbjct: 11  EANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFY 70

Query: 84  FDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKEN 143
           FDR+P++F +VL+FY TG+LH   + C+ +F +E+ ++G+    +  CC   Y  RK E 
Sbjct: 71  FDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVE- 129

Query: 144 AERLAEDEEAEQAG------------------DGPALPAGSSLRQRLWRAFENPHTSTAA 185
            E+   DE+++Q                    DG  L    + R++LW A +NP  S  +
Sbjct: 130 PEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPL---GNFRRQLWLALDNPGYSVLS 186

Query: 186 LVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGE 245
            VF  ++   +  S+I   + ++P        S+  P GE     F  ++   +  FT E
Sbjct: 187 RVFSILSILVVMGSIITMCLNSLP--DFQIPDSQGNP-GE--DPRFEIVEHFGIAWFTFE 241

Query: 246 YLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLV-------PKNDDVSGAFVTLRVFR 298
            + R   AP   +F ++ ++LID+++I+P+YI L+V       P   ++      LR+ R
Sbjct: 242 LVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMR 301

Query: 299 VFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTS 358
           +FRI K +RHS GLR LG TLK    E+G LL  L++ I IF+ V +  EK  N+    +
Sbjct: 302 IFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENE-GLAT 360

Query: 359 IPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQN 418
           IPA +W+  V+MTT+GYGD+VP T AGK+  S C L+G+LV+ LP+ +I + FS  Y + 
Sbjct: 361 IPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQ 420

Query: 419 QRAD 422
           ++ +
Sbjct: 421 KQLE 424


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,524,338
Number of Sequences: 37866
Number of extensions: 1223653
Number of successful extensions: 5971
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 5302
Number of HSP's gapped (non-prelim): 533
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.