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Search of human proteins with 27436953
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
(1617 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 3212 0.0
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 1883 0.0
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 1861 0.0
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 1771 0.0
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 1182 0.0
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 1182 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 493 e-139
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 279 2e-74
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 279 2e-74
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 276 9e-74
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 270 8e-72
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 270 8e-72
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 267 7e-71
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 259 1e-68
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 257 6e-68
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 107 9e-23
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 107 9e-23
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 107 9e-23
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 88 8e-17
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 88 8e-17
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 82 4e-15
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 82 4e-15
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 82 4e-15
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 82 4e-15
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 82 4e-15
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 82 4e-15
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 82 4e-15
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 82 4e-15
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 82 4e-15
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 80 2e-14
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 3212 bits (8327), Expect = 0.0
Identities = 1617/1617 (100%), Positives = 1617/1617 (100%)
Query: 1 MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA 60
MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA
Sbjct: 1 MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA 60
Query: 61 PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN 120
PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN
Sbjct: 61 PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN 120
Query: 121 LPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQT 180
LPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQT
Sbjct: 121 LPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQT 180
Query: 181 AINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISL 240
AINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISL
Sbjct: 181 AINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISL 240
Query: 241 NVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVI 300
NVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVI
Sbjct: 241 NVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVI 300
Query: 301 FILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILN 360
FILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILN
Sbjct: 301 FILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILN 360
Query: 361 ICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKI 420
ICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKI
Sbjct: 361 ICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKI 420
Query: 421 LPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRI 480
LPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRI
Sbjct: 421 LPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRI 480
Query: 481 RNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTI 540
RNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTI
Sbjct: 481 RNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTI 540
Query: 541 YNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILL 600
YNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILL
Sbjct: 541 YNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILL 600
Query: 601 ELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRER 660
ELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRER
Sbjct: 601 ELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRER 660
Query: 661 RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNP 720
RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNP
Sbjct: 661 RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNP 720
Query: 721 EQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMST 780
EQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMST
Sbjct: 721 EQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMST 780
Query: 781 LNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAM 840
LNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAM
Sbjct: 781 LNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAM 840
Query: 841 ARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLP 900
ARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLP
Sbjct: 841 ARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLP 900
Query: 901 QEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDY 960
QEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDY
Sbjct: 901 QEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDY 960
Query: 961 RFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFL 1020
RFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFL
Sbjct: 961 RFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFL 1020
Query: 1021 FLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIF 1080
FLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIF
Sbjct: 1021 FLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIF 1080
Query: 1081 YIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTI 1140
YIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTI
Sbjct: 1081 YIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTI 1140
Query: 1141 MFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVC 1200
MFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVC
Sbjct: 1141 MFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVC 1200
Query: 1201 FIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERI 1260
FIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERI
Sbjct: 1201 FIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERI 1260
Query: 1261 RTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLG 1320
RTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLG
Sbjct: 1261 RTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLG 1320
Query: 1321 PNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAA 1380
PNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAA
Sbjct: 1321 PNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAA 1380
Query: 1381 VKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPS 1440
VKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPS
Sbjct: 1381 VKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPS 1440
Query: 1441 TGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
TGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHL
Sbjct: 1441 TGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
Query: 1501 KNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTF 1560
KNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTF
Sbjct: 1501 KNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTF 1560
Query: 1561 HKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP 1617
HKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP
Sbjct: 1561 HKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP 1617
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 1884 bits (4879), Expect = 0.0
Identities = 958/1543 (62%), Positives = 1173/1543 (76%), Gaps = 18/1543 (1%)
Query: 90 MNKTALAPLLKGTSVIGAPNKTHMDEILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWK 149
MNK ALA +KG +VIG P++ MD L + +G+IF++TFSY+L F GY P+ K
Sbjct: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60
Query: 150 E--DFSAHCWDGYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITM 207
E +++ HCW +GE C L KYW +GFVA Q AIN AIIE+TTNH VMEEL SV I M
Sbjct: 61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120
Query: 208 KTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSW 267
K PFI+K + NE F L+ FS +YF SLNV +ER K K LM +MGL++SAFWLSW
Sbjct: 121 KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180
Query: 268 GLIYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVL 327
GL Y FIFI+SIF+ ++IT I+ TGFMVIF L+ LYGLSL+AL FLMSVL++K +L
Sbjct: 181 GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240
Query: 328 TNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP 387
L FL T+FWGCLGFTV Y QLP SL W+L++ SPFAFT GM QI LD L+GVIFP
Sbjct: 241 AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300
Query: 388 DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTN 447
DPSGDSY MIATF +L D L YL+ LYF+++LP D SPLFFL SS +HQ T+
Sbjct: 301 DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360
Query: 448 AKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEG 507
++ E EI+ EH SDD FEPV+PEF GKEAIRIRNV KEY GK+GKVEAL+G+ FDIYEG
Sbjct: 361 HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
Query: 508 QITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ 567
QITAILGH+GAGKS+LLNIL+GLSV TEGS TIYN LSE+ D+EEIRK G CPQFN Q
Sbjct: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
Query: 568 FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGI 627
FD LTV+ENL +FAKIKGI KEVEQEV+RI++ELDMQ+IQD +AK LS GQKRKLT GI
Sbjct: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
Query: 628 TILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMS 687
ILGDPQ+LLLDEPT GLDPFSR +VWSLL+E + D +ILFSTQ MDEADILADRKV +S
Sbjct: 541 AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600
Query: 688 NGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT 747
NG+LKCAGSS+FLKR+WG+GYHLSLHRNE+C+ E+ITS I HIPDAKL TE++EKLVY+
Sbjct: 601 NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660
Query: 748 LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTI-EQDF-----EQV 801
LPLE+TN FPDL+SDLDKCSDQG+ Y +S+++LNEVF+ LEG+S I E DF E++
Sbjct: 661 LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720
Query: 802 EMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLV 861
+ R++ +EME S E + AVS LWR Q++A+A LRFLKL+R+ + LL LLLV
Sbjct: 721 HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780
Query: 862 FGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFI 921
GIA P+I+E IMY + E WEF +YFLS Q+P+ P TSLLI+NNT SNIED +
Sbjct: 781 LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840
Query: 922 KSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNII 981
SLK Q+I+LE+DDF NRNG+D SYNGAIIVSG QKDYRFSV CNTK+L+CFP+LM I+
Sbjct: 841 HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900
Query: 982 SNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKK 1041
SN L+ +FN T+ I++ES+ F I L G DGS FL L+ +SP+I M SISDYKK
Sbjct: 901 SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960
Query: 1042 NAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIV 1101
N +SQLWISGL+ SAYWCGQALVD+ + LIL ++LI+Y + + L + +++F LV+
Sbjct: 961 NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQL-SWELMFVLVVC 1019
Query: 1102 TPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVL 1161
G A SL+F Y++SFIFRK RKN+G WSF FF + +I + ++ LI M+
Sbjct: 1020 IIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIF 1079
Query: 1162 VPSYTLLGFKTFLEVRD-QEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELK 1220
+PS+TLLG+ L D + E++ T L IPY Q+++F+FV+RC+E+K
Sbjct: 1080 IPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMK 1139
Query: 1221 CGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIAS 1280
G + M KDPVFRISP+SR+ PNPEEP +EDED+Q ER++ A ALT L+E+PVI AS
Sbjct: 1140 YGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITAS 1199
Query: 1281 CLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPT 1340
CLHKEY KKSCFS RKKKIA RN+SFCV++GE+LGLLG NGAGKS+SI+MI+G TKPT
Sbjct: 1200 CLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPT 1259
Query: 1341 AGEVELKGC--------SSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLA 1392
AG V L+G + L LGYCPQEN LWP LT++EHLE+YAAVKGL K DA L+
Sbjct: 1260 AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS 1319
Query: 1393 IARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMW 1452
I+RLV A KL EQL PV+ L+ GI RKLCFVLS+LGN V+LLDEP TG+DP GQQQMW
Sbjct: 1320 ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMW 1379
Query: 1453 QAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL 1512
Q +QA VKN ERG LLTTH ++EAEA+CDR+A+MVSG LRCIGSIQHLKNK G+DY+LE+
Sbjct: 1380 QILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI 1439
Query: 1513 KVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNL 1572
K+KE +QV +HTEILKLFPQAA QERYSSL+ YKLPV DV+PLS+ F KLEA+K FNL
Sbjct: 1440 KMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNL 1499
Query: 1573 EEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSD 1615
EEYSLSQ TLE+VFLEL KEQE+GN D++IDTT+ WKLLP D
Sbjct: 1500 EEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQED 1542
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 1861 bits (4821), Expect = 0.0
Identities = 950/1627 (58%), Positives = 1202/1627 (73%), Gaps = 24/1627 (1%)
Query: 1 MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQ-FPGM 59
M+ ++ SV QQT ALLCKN LKKWRMKR++LLEW S LL L + LF S++ V P M
Sbjct: 1 MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60
Query: 60 APQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLE 119
+ +LGRVD FN ++ ++ + P S TQ+IMNK A AP LKG +++G P++ MDE+ L
Sbjct: 61 SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120
Query: 120 NLPYAMGIIFNETFSYKLIFFQGYNSPLWKE--DFSAHCWDGYGEFSCTLTKYWNRGFVA 177
A+ +IF +TFSY L F G+ P+ KE D SAHC + C +++W +GFVA
Sbjct: 121 YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180
Query: 178 LQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYF 237
Q AIN AIIEI TNH VME+LMSVT + MK LPF+ + + + FI F ++ FS +Y+
Sbjct: 181 FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240
Query: 238 ISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGF 297
+S+NVT+ER+ +LM MMGL++SAFWLSWGL+YAGFI I++ + +I+ QI+V+TGF
Sbjct: 241 VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300
Query: 298 MVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEW 357
+++F LF LYGLSL+ L FLMSVL+KK LT LVVFLL +FWG LGF Y +LP+ LEW
Sbjct: 301 VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360
Query: 358 ILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYF 417
L + SPFAFT GM Q+I LDY++N D S + Y +IAT ML+ D L+YL+L LYF
Sbjct: 361 TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420
Query: 418 DKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA 477
DKILP SPLFFL S FQH R N V+E E D++ +D FEPV+PEF GKEA
Sbjct: 421 DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480
Query: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
IRI+N+KKEY GK +VEALKG++FDIYEGQITA+LGHSGAGK++LLNIL+GLSVPT GS
Sbjct: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
Query: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR 597
VT+YN LS M D+E I K TG CPQ NVQF LTVKENL LFAKIKGI EVE+EVQR
Sbjct: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600
Query: 598 ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL 657
++ EL+M+NIQD LA++LS GQ RKLTFGI ILGDPQ+LLLDEPT GLDP SR ++W+LL
Sbjct: 601 VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660
Query: 658 RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEI 717
+E ++D VILFSTQ +DEADILADRKV +SNG+LKCAGSS+FLK++WG+GYHLSLH NE
Sbjct: 661 KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720
Query: 718 CNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDIS 777
C+PE ITS + HI DAKL +++EKLVY LPLERTN FP+L+ DLD+CS+QG+ Y +S
Sbjct: 721 CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780
Query: 778 MSTLNEVFMKLEGQSTIEQD------FEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMG 831
++TLNEVF+KLEG+STI++ Q + +D SL E+E SSF E + +S +
Sbjct: 781 ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840
Query: 832 LWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNEL 891
LWR QV A+A++RFLKLK++ K L T+LL+FGI+ P ++E++ Y + WE
Sbjct: 841 LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900
Query: 892 YFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAI 951
YFLSPGQ PQ+P T LL+IN T S I++F+ SL+ QNI +EVD F RNGTD SYNGAI
Sbjct: 901 YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960
Query: 952 IVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWT 1011
IVSG +KD+RFS+ CNTKRL+CFP+L+++ISNGLL +FN ++HI+ + S F H+
Sbjct: 961 IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020
Query: 1012 GLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFIL 1071
G +FF + S +PYI M SI DYKK A SQL ISGLY SAYW GQALVDVS + L
Sbjct: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080
Query: 1072 ILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWS 1131
ILLLM ++ YI + + ++ Q + ++ + GY +SLVF Y+ISFIFR RKNSG+WS
Sbjct: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140
Query: 1132 FYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLG-FKTFLEVRDQEHYREFPEANF 1190
F+F T +N + L +L+P +TL+G F E+ P++
Sbjct: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEIS--------PDSMD 1192
Query: 1191 ELSATD----FLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPE 1246
L A++ +L IPY L+F+F+LRC+E+ C KK MRKDPVFRISP+S PNPE
Sbjct: 1193 YLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPE 1252
Query: 1247 EPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNI 1306
EP E+EDIQ ER+RT A+ DE PVIIASCL KEYAG+KK+CFSKRKKKIA RN+
Sbjct: 1253 EPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNV 1312
Query: 1307 SFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGC--SSVLGHLGYCPQENV 1364
SFCV++GE++GLLG NGAGKS++I+MI+G TKPTAG+V LKG LG LGYCPQEN
Sbjct: 1313 SFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENA 1372
Query: 1365 LWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFV 1424
LWP LT+R+HLEVYAAVKGLRK DA +AI RLV A KL +QL PV+ L+ GI RKLCFV
Sbjct: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
Query: 1425 LSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVA 1484
LS+LGN V+LLDEPSTG+DP GQQQMWQ I+A +NTERG LLTTH +AEAEA+CDRVA
Sbjct: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
Query: 1485 IMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLL 1544
IMVSGRLRCIGSIQHLK+K GKDY+LE+K+K +Q+ +H EIL+LFPQAA QER+SSL+
Sbjct: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLM 1552
Query: 1545 TYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDT 1604
YKLPV DV PLSQ F KLE VK +F+LEEYSLSQ TLE+VFLELSKEQE+G+ +E+ D
Sbjct: 1553 VYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDP 1612
Query: 1605 TMRWKLL 1611
+++WKLL
Sbjct: 1613 SVKWKLL 1619
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 1771 bits (4586), Expect = 0.0
Identities = 932/1628 (57%), Positives = 1149/1628 (70%), Gaps = 61/1628 (3%)
Query: 1 MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA 60
M ++ SV QQT ALLCKNFLKKWRMKRESL+EW S+LL LC+ ++ S + F +
Sbjct: 1 MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL 60
Query: 61 PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN 120
+LGRVD FN S VVYTP++N TQQIMNK A P L G V+G P++ + E
Sbjct: 61 TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY 120
Query: 121 LPYAMGIIFNETFSYKLIFFQGYNSPLWKE--DFSAHCWDGYGEFSCTLTKYWNRGFVAL 178
+ + F T+SY L F G+ P KE D +AHC++ + C ++ +W GFVAL
Sbjct: 121 PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL 180
Query: 179 QTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFI 238
Q AIN AIIEITTNH VMEELMSVT MK FI ++ + ++++ ++ FS +Y+
Sbjct: 181 QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA 240
Query: 239 SLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFM 298
S+NVT+ERK+ K LM MMGL+DSAFWLSWGL+YAGFIFI+++F+ ++I TQ I+++GFM
Sbjct: 241 SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM 300
Query: 299 VIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWI 358
V+F LF LYGLSLVAL FLMS+L+KK+ LT LVVFLLT+FWGCLGFT Y LP+SLEWI
Sbjct: 301 VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI 360
Query: 359 LNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFD 418
L++ SPFAF GM Q++ LDY+LN FP PS S ++AT ML D +YL LA+YF+
Sbjct: 361 LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
Query: 419 KILP--YGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKE 476
KILP YG R PLFFL SS Q Q+T+ +E E+DA+ D FE PEFQGKE
Sbjct: 421 KILPNEYGHRR--PPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKE 478
Query: 477 AIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEG 536
AIRIRNV KEYKGK K+EALK L+FDIYEGQITAILGHSGAGKS+LLNIL+GLSVPT+G
Sbjct: 479 AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKG 538
Query: 537 SVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQ 596
SVTIYN LSEM DLE + K+TGVCPQ NVQFD LTV+ENL LFAKIKGI +EV++E
Sbjct: 539 SVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE-- 596
Query: 597 RILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSL 656
I LLDEPT GLDPFSR QVW+L
Sbjct: 597 --------------------------------------IFLLDEPTAGLDPFSRHQVWNL 618
Query: 657 LRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNE 716
L+ER+ D VILFSTQ MDEADILADRKV +S G+LKCAGSS+FLK++WG+GYHLSL NE
Sbjct: 619 LKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNE 678
Query: 717 ICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDI 776
IC E ITS + HIPDAKL +++ KL+YTLPLERTN FP+L+ DLD D G+ Y +
Sbjct: 679 ICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGV 738
Query: 777 SMSTLNEVFMKLEGQSTI-EQDFE-----QVEMIRDSESLNEMELAHSSFSEMQTAVSDM 830
SM+TLNEVF+KLEG+STI E D Q E D+E L EME SS ++M+ + +
Sbjct: 739 SMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGV 798
Query: 831 GLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNE 890
LWR Q+ A+AR+R LKLK + K LL LLL+ PL+VE M + WE
Sbjct: 799 ALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPH 858
Query: 891 LYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGA 950
LYFL+PGQ P +P T LLIIN T ++I+DFI+S++HQNI LEVD F RNGTD SYNGA
Sbjct: 859 LYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGA 918
Query: 951 IIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLW 1010
I V +K+Y FS+ CN KRL+CFP+LM+I+SNGLL M + HIR E S F +
Sbjct: 919 ITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNP 978
Query: 1011 TGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFI 1070
G F ++ S PYI M SI DYK A+SQL ISGL SAYW GQALVDVS +
Sbjct: 979 IGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYF 1038
Query: 1071 LILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLW 1130
L+ + +YL+ YI N + +L+T + + GY+ SL+F Y+ISFIFRK RKNSG+W
Sbjct: 1039 LVFVFIYLMSYISNFEDMLLTIIHIIQIPCAV-GYSFSLIFMTYVISFIFRKGRKNSGIW 1097
Query: 1131 SFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYRE-FPEAN 1189
SF F+ + + + F+ I L+P T++G L + + F E
Sbjct: 1098 SFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGC---LFLSSHLLFSSLFSEER 1154
Query: 1190 FELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPI 1249
++ FLV IP+ ++F+F LRC+E K GKK MRKDP FRISP+S D NPEEP
Sbjct: 1155 MDVQP--FLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPE 1212
Query: 1250 DEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFC 1309
EDED+Q ER+RTA AL ++ DEKPVIIASCL KEYAG++K CFSKRK KIA RN+SFC
Sbjct: 1213 GEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFC 1272
Query: 1310 VQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS--VLGHLGYCPQENVLWP 1367
V++GE+LGLLG NGAGKS+SI++I+G TKPTAG+V LKG L LGYCPQEN LWP
Sbjct: 1273 VRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWP 1332
Query: 1368 MLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSL 1427
LT+R+HLEVYAAVKGLRK DA +AI RLV A KL +QL PV+ L+ GI RKLCFVLS+
Sbjct: 1333 NLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSI 1392
Query: 1428 LGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMV 1487
LGN V+LLDEPSTG+DP GQQQMWQAI+A +NTERG LLTTH +AEAEA+CDRVAIMV
Sbjct: 1393 LGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMV 1452
Query: 1488 SGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYK 1547
SGRLRCIGSIQHLK+K GKDY+LE+KVK +QV +H EIL+LFPQAA QERYSSL+ YK
Sbjct: 1453 SGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYK 1512
Query: 1548 LPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMR 1607
LPV DV PL+Q F KLE VK +F+LEEYSLSQ TLE+VFLELSKEQE+G+F+E+ D +++
Sbjct: 1513 LPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVK 1572
Query: 1608 WKLLPHSD 1615
WKLLP +
Sbjct: 1573 WKLLPQEE 1580
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1182 bits (3058), Expect = 0.0
Identities = 683/1659 (41%), Positives = 1011/1659 (60%), Gaps = 82/1659 (4%)
Query: 3 MKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMAPQ 62
+++ V++QT+ LL KN+L K R K+ S+ E + + L S N ++ +
Sbjct: 5 IREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNI 64
Query: 63 NLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLP 122
L +DKF S+L++ YTP++N+T IM K + L VI T+ E+L +L
Sbjct: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHL---PDVIITEEYTNEKEMLTSSLS 121
Query: 123 YA---MGIIFNETFSYKLIFFQGYN--SPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVA 177
+G++F ++ SY+L FF S ++ D A C SC +YW+ GF
Sbjct: 122 KPSNFVGVVFKDSMSYELRFFPDMIPVSSIYM-DSRAGC-----SKSCEAAQYWSSGFTV 175
Query: 178 LQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYF 237
LQ +I+ AII++ TN + +EL S A+ M + + + +++ ++ FSP YF
Sbjct: 176 LQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYF 235
Query: 238 ISLNVTKER-KKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTG 296
+++++ E+ KK K +K+MGL D+AFWLSW L+Y IF++S+ + +I T + + +
Sbjct: 236 LAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSS 295
Query: 297 FMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY-EQLPSSL 355
+VIF+LFFLYGLS V +++ L KK+ +V F +T+ +G +G + E P SL
Sbjct: 296 SIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSL 355
Query: 356 EWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLAL 415
W+ + F G+ Q++ L+ G F + + Y +I T ML L+ + Y+LLA+
Sbjct: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAV 415
Query: 416 YFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGK 475
Y D+++P S L+FL S + +R ++ E ++ + EPV+ EF GK
Sbjct: 416 YLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGK 475
Query: 476 EAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTE 535
EAIRI ++K Y+ K VEAL+ L FDIYEGQITA+LGHSG GKS+L+NIL GL P++
Sbjct: 476 EAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535
Query: 536 GSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEV 595
G +IY +SE+ ++ E RK+ G+CPQ ++ FD+LTV+ENLS+ A IKGI + QEV
Sbjct: 536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEV 595
Query: 596 QRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWS 655
Q++LL+LDMQ I+DN AK LS GQKRKL+ GI +LG+P+ILLLDEPT G+DP SR VW+
Sbjct: 596 QKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN 655
Query: 656 LLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN 715
LL+ R+A+ V +FST MDEADILADRK ++S G LKC GSSMFLK +WG+GY LS++ +
Sbjct: 656 LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYID 715
Query: 716 EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYD 775
+ C E ++S + HIP A L +N ++LVY+LP + + F LFS LD S+ GV Y
Sbjct: 716 KYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYG 775
Query: 776 ISMSTLNEVFMKLEGQSTIEQ-DF-----EQVEMIRDSESLNEMELAHSSFSEMQTA-VS 828
+SM+TL +VF+KLE ++ I+Q D+ + +E DS+S +EME + SE + A VS
Sbjct: 776 VSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVS 835
Query: 829 DMGLWRMQVFAMARLRFLKLKRQTK----VLLTLLLVFGIAIFPLIVENIMYAMLNEKID 884
M LW+ Q++ +A+ F LKR++K VLL LL+ F + IF +V ++ N +
Sbjct: 836 TMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVH---HSFKNAVVP 892
Query: 885 WEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDG 944
+ +LYFL PG P + +TSLL+ N+ +S+I D I QNI++ + N +D
Sbjct: 893 IKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM-----INDSDY 947
Query: 945 LS---YNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSP 1001
+S ++ A+ V +KDY F+ V N+ ++ PIL+NIISN L N T+ I+I S+P
Sbjct: 948 VSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTP 1007
Query: 1002 F--PLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWC 1059
F ++ I L + L +++ ++ PY M + ++K A +QL +SGL SAYW
Sbjct: 1008 FFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWI 1067
Query: 1060 GQALVDVSFFILILLLM---YLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMI 1116
GQA+VD+ F +IL+LM L F+ Y + +VF L+ GY S++ F Y+
Sbjct: 1068 GQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLI----GYVPSVILFTYIA 1123
Query: 1117 SFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTM------VLVPSYTLLG- 1169
SF F+K WSF + A+ +IT I F + I T+ +++P Y LLG
Sbjct: 1124 SFTFKKILNTKEFWSFIYSVAALACIAITEITFF-MGYTIATILHYAFCIIIPIYPLLGC 1182
Query: 1170 FKTFLEV------RDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGK 1223
+F+++ ++ + Y + + + PY Q +L++F+L+ E K G
Sbjct: 1183 LISFIKISWKNVRKNVDTYNPWDRLS--------VAVISPYLQCVLWIFLLQYYEKKYGG 1234
Query: 1224 KRMRKDPVFR-ISPQSRDAK-PNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASC 1281
+ +RKDP FR +S +S++ K P P + DEDED++ ER++ + +EKP I+ S
Sbjct: 1235 RSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSN 1294
Query: 1282 LHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA 1341
LHKEY +K S++ KK+A + ISFCV++GEILGLLGPNGAGKS+ I ++ G +PT+
Sbjct: 1295 LHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS 1354
Query: 1342 GEVELKGCSS-------VLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIA 1394
G+V L SS L +GYCPQ N LWP TL+EH E+Y AVKG+ +D + I+
Sbjct: 1355 GQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVIS 1414
Query: 1395 RLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQA 1454
R+ A L E L V+KL AGI RKLCF LS+LGN + LLDEPSTG+DP +Q MW+A
Sbjct: 1415 RITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRA 1474
Query: 1455 IQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV 1514
I+ KN +R +LTTH + EAEA+CDRVAIMVSG+LRCIG++QHLK+K GK Y LE+K+
Sbjct: 1475 IRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKL 1534
Query: 1515 K---ETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFN 1571
K E +V + EI +FP A+ QE +SS+L YK+P DV LSQ+F KLE KH F
Sbjct: 1535 KDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFA 1594
Query: 1572 LEEYSLSQCTLEKVFLELSKEQ-EVGNFDEEIDTTMRWK 1609
+EEYS SQ TLE+VF+EL+KEQ E N +++T+ W+
Sbjct: 1595 IEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE 1633
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1182 bits (3058), Expect = 0.0
Identities = 683/1659 (41%), Positives = 1011/1659 (60%), Gaps = 82/1659 (4%)
Query: 3 MKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMAPQ 62
+++ V++QT+ LL KN+L K R K+ S+ E + + L S N ++ +
Sbjct: 5 IREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNI 64
Query: 63 NLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLP 122
L +DKF S+L++ YTP++N+T IM K + L VI T+ E+L +L
Sbjct: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHL---PDVIITEEYTNEKEMLTSSLS 121
Query: 123 YA---MGIIFNETFSYKLIFFQGYN--SPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVA 177
+G++F ++ SY+L FF S ++ D A C SC +YW+ GF
Sbjct: 122 KPSNFVGVVFKDSMSYELRFFPDMIPVSSIYM-DSRAGC-----SKSCEAAQYWSSGFTV 175
Query: 178 LQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYF 237
LQ +I+ AII++ TN + +EL S A+ M + + + +++ ++ FSP YF
Sbjct: 176 LQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYF 235
Query: 238 ISLNVTKER-KKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTG 296
+++++ E+ KK K +K+MGL D+AFWLSW L+Y IF++S+ + +I T + + +
Sbjct: 236 LAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSS 295
Query: 297 FMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY-EQLPSSL 355
+VIF+LFFLYGLS V +++ L KK+ +V F +T+ +G +G + E P SL
Sbjct: 296 SIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSL 355
Query: 356 EWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLAL 415
W+ + F G+ Q++ L+ G F + + Y +I T ML L+ + Y+LLA+
Sbjct: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAV 415
Query: 416 YFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGK 475
Y D+++P S L+FL S + +R ++ E ++ + EPV+ EF GK
Sbjct: 416 YLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGK 475
Query: 476 EAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTE 535
EAIRI ++K Y+ K VEAL+ L FDIYEGQITA+LGHSG GKS+L+NIL GL P++
Sbjct: 476 EAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535
Query: 536 GSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEV 595
G +IY +SE+ ++ E RK+ G+CPQ ++ FD+LTV+ENLS+ A IKGI + QEV
Sbjct: 536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEV 595
Query: 596 QRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWS 655
Q++LL+LDMQ I+DN AK LS GQKRKL+ GI +LG+P+ILLLDEPT G+DP SR VW+
Sbjct: 596 QKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN 655
Query: 656 LLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN 715
LL+ R+A+ V +FST MDEADILADRK ++S G LKC GSSMFLK +WG+GY LS++ +
Sbjct: 656 LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYID 715
Query: 716 EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYD 775
+ C E ++S + HIP A L +N ++LVY+LP + + F LFS LD S+ GV Y
Sbjct: 716 KYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYG 775
Query: 776 ISMSTLNEVFMKLEGQSTIEQ-DF-----EQVEMIRDSESLNEMELAHSSFSEMQTA-VS 828
+SM+TL +VF+KLE ++ I+Q D+ + +E DS+S +EME + SE + A VS
Sbjct: 776 VSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVS 835
Query: 829 DMGLWRMQVFAMARLRFLKLKRQTK----VLLTLLLVFGIAIFPLIVENIMYAMLNEKID 884
M LW+ Q++ +A+ F LKR++K VLL LL+ F + IF +V ++ N +
Sbjct: 836 TMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVH---HSFKNAVVP 892
Query: 885 WEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDG 944
+ +LYFL PG P + +TSLL+ N+ +S+I D I QNI++ + N +D
Sbjct: 893 IKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM-----INDSDY 947
Query: 945 LS---YNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSP 1001
+S ++ A+ V +KDY F+ V N+ ++ PIL+NIISN L N T+ I+I S+P
Sbjct: 948 VSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTP 1007
Query: 1002 F--PLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWC 1059
F ++ I L + L +++ ++ PY M + ++K A +QL +SGL SAYW
Sbjct: 1008 FFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWI 1067
Query: 1060 GQALVDVSFFILILLLM---YLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMI 1116
GQA+VD+ F +IL+LM L F+ Y + +VF L+ GY S++ F Y+
Sbjct: 1068 GQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLI----GYVPSVILFTYIA 1123
Query: 1117 SFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTM------VLVPSYTLLG- 1169
SF F+K WSF + A+ +IT I F + I T+ +++P Y LLG
Sbjct: 1124 SFTFKKILNTKEFWSFIYSVAALACIAITEITFF-MGYTIATILHYAFCIIIPIYPLLGC 1182
Query: 1170 FKTFLEV------RDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGK 1223
+F+++ ++ + Y + + + PY Q +L++F+L+ E K G
Sbjct: 1183 LISFIKISWKNVRKNVDTYNPWDRLS--------VAVISPYLQCVLWIFLLQYYEKKYGG 1234
Query: 1224 KRMRKDPVFR-ISPQSRDAK-PNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASC 1281
+ +RKDP FR +S +S++ K P P + DEDED++ ER++ + +EKP I+ S
Sbjct: 1235 RSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSN 1294
Query: 1282 LHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA 1341
LHKEY +K S++ KK+A + ISFCV++GEILGLLGPNGAGKS+ I ++ G +PT+
Sbjct: 1295 LHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS 1354
Query: 1342 GEVELKGCSS-------VLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIA 1394
G+V L SS L +GYCPQ N LWP TL+EH E+Y AVKG+ +D + I+
Sbjct: 1355 GQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVIS 1414
Query: 1395 RLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQA 1454
R+ A L E L V+KL AGI RKLCF LS+LGN + LLDEPSTG+DP +Q MW+A
Sbjct: 1415 RITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRA 1474
Query: 1455 IQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV 1514
I+ KN +R +LTTH + EAEA+CDRVAIMVSG+LRCIG++QHLK+K GK Y LE+K+
Sbjct: 1475 IRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKL 1534
Query: 1515 K---ETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFN 1571
K E +V + EI +FP A+ QE +SS+L YK+P DV LSQ+F KLE KH F
Sbjct: 1535 KDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFA 1594
Query: 1572 LEEYSLSQCTLEKVFLELSKEQ-EVGNFDEEIDTTMRWK 1609
+EEYS SQ TLE+VF+EL+KEQ E N +++T+ W+
Sbjct: 1595 IEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE 1633
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 493 bits (1270), Expect = e-139
Identities = 446/1735 (25%), Positives = 814/1735 (46%), Gaps = 188/1735 (10%)
Query: 7 SVYQQTKALLCKNFLKKWRMKRESLLEWGL-----SILLGLCIALFSSSMRNVQ-FPGMA 60
+V +Q LL KN+ + R ++LE L IL+ L + + S ++ N +PG +
Sbjct: 2 AVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQS 61
Query: 61 PQNLGRVDKFN--SSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPN-KTHMDEIL 117
Q L F + + Y P + + + +T L+ V G P+ K D I
Sbjct: 62 IQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIR 121
Query: 118 LENLPYAM--GIIFNETFS-----------YKLIFFQGYNSPLWKEDFSAHCWDGYGEFS 164
+N ++ ++F F+ Y L F + +W + S + G +
Sbjct: 122 YDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHT 181
Query: 165 CTLTK-------------------YWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAI 205
+L Y GF+A+Q A++ AI+E + + +T +
Sbjct: 182 TSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLT-V 240
Query: 206 TMKTLP---FITKNLLHNEMFIL--FFLLHFSPLVYFISLNVTKERKKS-KNLMKMMGLQ 259
T+K P FI L + L LL F+ I+ V +E+++ K M+MMGL
Sbjct: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
Query: 260 DSAFWLSWGLIYAGFIFIISIFVTIIITFT---QIIVMTGFMVIFILFFL--YGLSLVAL 314
W +W L++ F+ I + F+T++ + V++ +L FL + +S ++
Sbjct: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
Query: 315 VFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVF--YEQLPSSLEWILNICSPFAFTTGMI 372
F++S KA + L F F V Y + S + + S A G
Sbjct: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
Query: 373 QIIKLDYNLNGV-----IFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGD 425
I K + G+ + P D + MLLLD ++Y L+ Y + + P +G
Sbjct: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
Query: 426 ERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHP-SDDYFEPVAPEFQGKEAIRIRNVK 484
+ + FF+ S R A E++ D E ++YFE + I+I+++
Sbjct: 481 PQPW--YFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVA--GIKIKHLS 536
Query: 485 KEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKN 544
K ++ + A++ L ++YEGQIT +LGH+GAGK++ L++L GL PT G I
Sbjct: 537 KVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYE 596
Query: 545 LSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDM 604
+S QD+ +IRK G+CPQ ++ FD LTV E+L +A++KG+ ++ +EV+++L + +
Sbjct: 597 IS--QDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGL 654
Query: 605 QNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADH 664
++ ++ ++ LS G +RKL+ GI ++ ++L+LDEPT+G+D SR +W LL+ +++D
Sbjct: 655 EDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDR 714
Query: 665 VILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQIT 724
I+ +T MDEAD+L DR IM+ G L+C GSS+FLK+++G GYH++L + CNPE I+
Sbjct: 715 TIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDIS 774
Query: 725 SFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQ-GVTGYDISMSTLNE 783
+ HH+P+A L++ +L + LP E T+ F LF+ L+K + G+ + S++T+ E
Sbjct: 775 QLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEE 834
Query: 784 VFMKLEGQSTIEQDFEQVEM--------------IRDSESLNEMELAH---SSFSEMQTA 826
VF+++ D + +++ DS M+ + + E +TA
Sbjct: 835 VFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTA 894
Query: 827 V---SDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKI 883
V + + L Q +AM + R+ K++ +LV PL + +N
Sbjct: 895 VKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLV------PLTCVTLALLAINYSS 948
Query: 884 DWEFKNELYFLSPGQLPQE------PRTSLLIINNTESNIEDFIKS--LKHQNILLEVDD 935
+ F + + L+ G+ + P TS L +E +++D +++ + + +L ++++
Sbjct: 949 EL-FDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSE-HLKDALQAEGQEPREVLGDLEE 1006
Query: 936 F-ENRNGTDGLSYNGAIIVSGKQKDYR----FSVVCNTKRLHCFPILMNIISNGLLQMFN 990
F R +G +N +V+ +D + + N + H + ++ N L ++
Sbjct: 1007 FLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLL- 1065
Query: 991 HTQHIRIESSPFPLSHIGLWTGLP---------DGSFFLFLVLCSISPYITMGSISDYKK 1041
H I S FP L D + L + ++ ++ ++S+
Sbjct: 1066 CGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAV 1125
Query: 1042 NAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIV 1101
AK ++SG++ +++W L D+ F++ LL+ ++F +++ + L+++
Sbjct: 1126 QAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLL 1185
Query: 1102 TPGYAASLVFFIYMISFIF---RKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITT 1158
Y +++ +Y+++F F +++ A+ +M +I I L L T
Sbjct: 1186 LL-YGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKT 1244
Query: 1159 M----VLVPSYTL-LGFKTFLEVRDQEHYREFPEA--------------NFELSATDFLV 1199
+ +++P++ L + +F E + Y E NF + +
Sbjct: 1245 LDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVG 1304
Query: 1200 CFIPYFQT-----LLFVFVL------RCMELKCGKKRMRK-DPVFRISPQSRDAKPNPEE 1247
F+ L+ +F++ R + C +R R ++ P
Sbjct: 1305 RFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMP----------- 1353
Query: 1248 PIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNIS 1307
+ ED+D+ ER R S+L P+II + + +R +A +S
Sbjct: 1354 VLPEDQDVADERTRILAPSPDSLL-HTPLIIK---------ELSKVYEQRVPLLAVDRLS 1403
Query: 1308 FCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG--CSSVLG----HLGYCPQ 1361
VQ+GE GLLG NGAGK+++ +M++G T+G+ + G SS +G +GYCPQ
Sbjct: 1404 LAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQ 1463
Query: 1362 ENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKL 1421
+ L +T RE L +YA ++G+ + + + L N V+ + G RKL
Sbjct: 1464 FDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKL 1523
Query: 1422 CFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCD 1481
++L+G V+ LDEPSTG+DP ++ +W + A + + + +++T+H++ E EALC
Sbjct: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECEALCT 1582
Query: 1482 RVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVH---TEILKLFPQAAGQE 1538
R+AIMV G+ +C+GS QHLK+K G Y L KV+ Q + + FP + ++
Sbjct: 1583 RLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLED 1642
Query: 1539 RYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQ 1593
+ ++ Y LP D+ ++ F LE K + +++YS+SQ +LE+VFL + Q
Sbjct: 1643 EHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 279 bits (713), Expect = 2e-74
Identities = 207/707 (29%), Positives = 362/707 (51%), Gaps = 89/707 (12%)
Query: 170 YWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLL 229
Y+ GFV +Q + AII+ H V+E + + M P T++ LF +
Sbjct: 655 YFLYGFVWIQDMMERAIIDTFVGHDVVEP---GSYVQMFPYPCYTRD------DFLFVIE 705
Query: 230 HFSPL------VYFISLN----VTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFI-I 278
H PL VY +++ V ++ + K +MK MGL ++ W++W + GF+ + I
Sbjct: 706 HMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFI--TGFVQLSI 763
Query: 279 SIF-VTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTN----LVVF 333
S+ +T I+ + Q+++ + ++I++ +Y ++ + FL+SVL KA L + ++ F
Sbjct: 764 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 823
Query: 334 L--LTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTG-----MIQIIKLDYNLNGVIF 386
L + + + V ++++ + + I ++ S AF G + ++ + +
Sbjct: 824 LSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQ 883
Query: 387 PDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERH-YSPL---FFLNSSSC 440
GD + ++ +ML++D ++Y +L Y + + P YG R Y PL ++L S
Sbjct: 884 SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRT 943
Query: 441 ------FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKE--------AIRIRNVKKE 486
+ RT + +E A FE E +G E + + + K
Sbjct: 944 EAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEEPTHLPLVVCVDKLTKV 999
Query: 487 YKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLS 546
YK K AL L ++YE Q+ + LGH+GAGK++ ++IL GL PT GS TIY ++
Sbjct: 1000 YK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIR 1057
Query: 547 EMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQN 606
+++EIRK G+CPQ NV FD LTV+E+L ++++K + +E+ +E+ +++ +L++ N
Sbjct: 1058 T--EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSN 1115
Query: 607 IQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVI 666
+ +L + LS G KRKL+ I +G + ++LDEPT G+DP++R +W L+ + + I
Sbjct: 1116 KRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTI 1175
Query: 667 LFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN----------- 715
L ST MDEAD+L DR I+S+G+LKC GS +FLK +G GY L+L +
Sbjct: 1176 LLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPG 1235
Query: 716 -----------EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLE--RTNTFPDLFSD 762
C+ Q++ FI H+ L ++ +L Y LP E + F LF
Sbjct: 1236 LASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQH 1295
Query: 763 LDKCSDQ-GVTGYDISMSTLNEVFMKL--EGQSTIEQDFEQVEMIRD 806
L++ D ++ + + +TL EVF+K+ E QS + + E +D
Sbjct: 1296 LERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD 1342
Score = 216 bits (549), Expect = 2e-55
Identities = 184/670 (27%), Positives = 311/670 (46%), Gaps = 74/670 (11%)
Query: 964 VVCNTKRLHCFPILMNIISNGLLQM-------------FNHTQH-IRIESSPFPLSHIGL 1009
V N K H P +N ++N +L+ T H + S+ L ++
Sbjct: 1730 VFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQ 1789
Query: 1010 WTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQA------- 1062
T + + F+ + + + + +++ AK ++SG YW
Sbjct: 1790 GTDVVI-AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNY 1848
Query: 1063 LVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTP-GYAASLVFFIYMISFIFR 1121
LV + ++IL + L Y + + S + +TP Y AS F + +++F
Sbjct: 1849 LVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1908
Query: 1122 KRRKNSGLWSFYFFFASTIMFSITLINHF-DLSI----LITTMVLVPSYTLLGFKTFLEV 1176
+ F A+ F + L H DL + L + ++ P+Y L +E+
Sbjct: 1909 -----IVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNL--GHGLMEM 1961
Query: 1177 RDQEHYREFPE--ANFELSATDFLVCFIPYFQTLLFV-----FVLRCMELKCGKKRMRKD 1229
E+ E+ F+ + F + + V F+L M C +R+
Sbjct: 1962 AYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIM---CQYNFLRR- 2017
Query: 1230 PVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQ 1289
PQ P +P+++D D+ +ER R + ++ L K Y +
Sbjct: 2018 ------PQRM---PVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSR 2063
Query: 1290 KKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGC 1349
K + +A + V+ GE GLLG NGAGK+S+ +M++G T GE + G
Sbjct: 2064 KIG------RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGH 2117
Query: 1350 S------SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLH 1403
S V LGYCPQ + L+ LT REHL++Y ++G+ D + + +L
Sbjct: 2118 SVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELT 2177
Query: 1404 EQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTE 1463
+ + P + G RKL ++L+G + LDEP+TG+DP ++ +W I ++K T
Sbjct: 2178 KYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TG 2236
Query: 1464 RGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLV 1523
R V+LT+H++ E EALC R+AIMV+GRLRC+GSIQHLKN+ G Y++ ++ K + V V
Sbjct: 2237 RSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDV 2296
Query: 1524 HTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLE 1583
+ FP+A +ER+ + + Y+L ++ L+Q F K+E V +E+YS+SQ TL+
Sbjct: 2297 VRFFNRNFPEAMLKERHHTKVQYQLK-SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLD 2355
Query: 1584 KVFLELSKEQ 1593
VF+ +K+Q
Sbjct: 2356 NVFVNFAKKQ 2365
Score = 188 bits (478), Expect = 3e-47
Identities = 151/632 (23%), Positives = 290/632 (45%), Gaps = 30/632 (4%)
Query: 183 NTAIIEIT-TNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLN 241
N A IT TNHP+ + S++ L ++ + + + F P + + L
Sbjct: 1762 NPAAYGITVTNHPMNKTSASLS------LDYLLQGTDVVIAIFIIVAMSFVPASFVVFL- 1814
Query: 242 VTKERKKSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQIIVMTGFM 298
V ++ K+K+L + G +WL+ W ++ + + + T F
Sbjct: 1815 VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFP 1874
Query: 299 VIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWI 358
+ LF LYG S+ +++ S + + + ++ LF G + +
Sbjct: 1875 AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKD 1934
Query: 359 LNICSPFAFTTGMI-QIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLL----DGLIYLLL 413
L + + + + +I L + L + + + + Y I F + D + L+
Sbjct: 1935 LKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 1994
Query: 414 ALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQ 473
A+ + ++ + + + N Q + K +E ++D A
Sbjct: 1995 AMAVEGVVGF----LLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADN-- 2048
Query: 474 GKEAIRIRNVKKEYKG-KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSV 532
+ ++I N+ K YK K G++ A+ L + G+ +LG +GAGK+S +L G
Sbjct: 2049 --DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDES 2106
Query: 533 PTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVE 592
T G + ++ +++L ++++ G CPQ + FD LT +E+L L+ +++GI K+
Sbjct: 2107 TTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEA 2164
Query: 593 QEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
+ V+ L +L++ D A S G KRKL+ I ++G P + LDEPTTG+DP +R
Sbjct: 2165 RVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRF 2224
Query: 653 VWSLLRER-RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLS 711
+W+L+ + + ++ ++ SM+E + L R IM NGRL+C GS LK R+G GY ++
Sbjct: 2225 LWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMIT 2284
Query: 712 LHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSD-QG 770
+ + + + F + P+A LK + K+ Y L E + +FS +++ S G
Sbjct: 2285 VRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLG 2343
Query: 771 VTGYDISMSTLNEVFMKLEGQSTIEQDFEQVE 802
+ Y +S +TL+ VF+ + + + ++ E
Sbjct: 2344 IEDYSVSQTTLDNVFVNFAKKQSDNLEQQETE 2375
Score = 154 bits (388), Expect = 9e-37
Identities = 104/353 (29%), Positives = 176/353 (49%), Gaps = 34/353 (9%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------C 1349
K KK+A +S + E +++ LG NGAGK++++ +++G+ PT+G + G
Sbjct: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060
Query: 1350 SSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVP 1409
+ +LG CPQ NVL+ LT+ EHL Y+ +K + + + R + +++ +L + +
Sbjct: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
VQ L+ G+ RKL ++ +G S ++LDEP+ G+DP ++ +W I + R +LL+
Sbjct: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI--LKYKPGRTILLS 1178
Query: 1470 THNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILK 1529
TH++ EA+ L DR+AI+ G+L+C GS LK G Y L L + +
Sbjct: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238
Query: 1530 LFPQAAGQERYSSL----------------------LTYKLP--VADVYPLSQTFHKLEA 1565
P A S L L+Y LP A + F LE
Sbjct: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298
Query: 1566 VKHNFNLEEYSLSQCTLEKVFLELSKE-QEVGNFDEEIDTTMRWKLLPHSDEP 1617
+L + L TLE+VFL++S+E Q + N + ++ + R +LP ++ P
Sbjct: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES-RKDVLPGAEGP 1350
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 279 bits (713), Expect = 2e-74
Identities = 207/707 (29%), Positives = 362/707 (51%), Gaps = 89/707 (12%)
Query: 170 YWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLL 229
Y+ GFV +Q + AII+ H V+E + + M P T++ LF +
Sbjct: 685 YFLYGFVWIQDMMERAIIDTFVGHDVVEP---GSYVQMFPYPCYTRD------DFLFVIE 735
Query: 230 HFSPL------VYFISLN----VTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFI-I 278
H PL VY +++ V ++ + K +MK MGL ++ W++W + GF+ + I
Sbjct: 736 HMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFI--TGFVQLSI 793
Query: 279 SIF-VTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTN----LVVF 333
S+ +T I+ + Q+++ + ++I++ +Y ++ + FL+SVL KA L + ++ F
Sbjct: 794 SVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYF 853
Query: 334 L--LTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTG-----MIQIIKLDYNLNGVIF 386
L + + + V ++++ + + I ++ S AF G + ++ + +
Sbjct: 854 LSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQ 913
Query: 387 PDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERH-YSPL---FFLNSSSC 440
GD + ++ +ML++D ++Y +L Y + + P YG R Y PL ++L S
Sbjct: 914 SPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRT 973
Query: 441 ------FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKE--------AIRIRNVKKE 486
+ RT + +E A FE E +G E + + + K
Sbjct: 974 EAWEWSWPWARTPRLSVMEEDQACAMESRRFE----ETRGMEEEPTHLPLVVCVDKLTKV 1029
Query: 487 YKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLS 546
YK K AL L ++YE Q+ + LGH+GAGK++ ++IL GL PT GS TIY ++
Sbjct: 1030 YK--DDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIR 1087
Query: 547 EMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQN 606
+++EIRK G+CPQ NV FD LTV+E+L ++++K + +E+ +E+ +++ +L++ N
Sbjct: 1088 T--EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSN 1145
Query: 607 IQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVI 666
+ +L + LS G KRKL+ I +G + ++LDEPT G+DP++R +W L+ + + I
Sbjct: 1146 KRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTI 1205
Query: 667 LFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN----------- 715
L ST MDEAD+L DR I+S+G+LKC GS +FLK +G GY L+L +
Sbjct: 1206 LLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPG 1265
Query: 716 -----------EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLE--RTNTFPDLFSD 762
C+ Q++ FI H+ L ++ +L Y LP E + F LF
Sbjct: 1266 LASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQH 1325
Query: 763 LDKCSDQ-GVTGYDISMSTLNEVFMKL--EGQSTIEQDFEQVEMIRD 806
L++ D ++ + + +TL EVF+K+ E QS + + E +D
Sbjct: 1326 LERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKD 1372
Score = 216 bits (549), Expect = 2e-55
Identities = 184/670 (27%), Positives = 311/670 (46%), Gaps = 74/670 (11%)
Query: 964 VVCNTKRLHCFPILMNIISNGLLQM-------------FNHTQH-IRIESSPFPLSHIGL 1009
V N K H P +N ++N +L+ T H + S+ L ++
Sbjct: 1760 VFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQ 1819
Query: 1010 WTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQA------- 1062
T + + F+ + + + + +++ AK ++SG YW
Sbjct: 1820 GTDVVI-AIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNY 1878
Query: 1063 LVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTP-GYAASLVFFIYMISFIFR 1121
LV + ++IL + L Y + + S + +TP Y AS F + +++F
Sbjct: 1879 LVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1938
Query: 1122 KRRKNSGLWSFYFFFASTIMFSITLINHF-DLSI----LITTMVLVPSYTLLGFKTFLEV 1176
+ F A+ F + L H DL + L + ++ P+Y L +E+
Sbjct: 1939 -----IVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNL--GHGLMEM 1991
Query: 1177 RDQEHYREFPE--ANFELSATDFLVCFIPYFQTLLFV-----FVLRCMELKCGKKRMRKD 1229
E+ E+ F+ + F + + V F+L M C +R+
Sbjct: 1992 AYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIM---CQYNFLRR- 2047
Query: 1230 PVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQ 1289
PQ P +P+++D D+ +ER R + ++ L K Y +
Sbjct: 2048 ------PQRM---PVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSR 2093
Query: 1290 KKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGC 1349
K + +A + V+ GE GLLG NGAGK+S+ +M++G T GE + G
Sbjct: 2094 KIG------RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGH 2147
Query: 1350 S------SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLH 1403
S V LGYCPQ + L+ LT REHL++Y ++G+ D + + +L
Sbjct: 2148 SVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELT 2207
Query: 1404 EQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTE 1463
+ + P + G RKL ++L+G + LDEP+TG+DP ++ +W I ++K T
Sbjct: 2208 KYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK-TG 2266
Query: 1464 RGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLV 1523
R V+LT+H++ E EALC R+AIMV+GRLRC+GSIQHLKN+ G Y++ ++ K + V V
Sbjct: 2267 RSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDV 2326
Query: 1524 HTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLE 1583
+ FP+A +ER+ + + Y+L ++ L+Q F K+E V +E+YS+SQ TL+
Sbjct: 2327 VRFFNRNFPEAMLKERHHTKVQYQLK-SEHISLAQVFSKMEQVSGVLGIEDYSVSQTTLD 2385
Query: 1584 KVFLELSKEQ 1593
VF+ +K+Q
Sbjct: 2386 NVFVNFAKKQ 2395
Score = 188 bits (478), Expect = 3e-47
Identities = 151/632 (23%), Positives = 290/632 (45%), Gaps = 30/632 (4%)
Query: 183 NTAIIEIT-TNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLN 241
N A IT TNHP+ + S++ L ++ + + + F P + + L
Sbjct: 1792 NPAAYGITVTNHPMNKTSASLS------LDYLLQGTDVVIAIFIIVAMSFVPASFVVFL- 1844
Query: 242 VTKERKKSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQIIVMTGFM 298
V ++ K+K+L + G +WL+ W ++ + + + T F
Sbjct: 1845 VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFP 1904
Query: 299 VIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWI 358
+ LF LYG S+ +++ S + + + ++ LF G + +
Sbjct: 1905 AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKD 1964
Query: 359 LNICSPFAFTTGMI-QIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLL----DGLIYLLL 413
L + + + + +I L + L + + + + Y I F + D + L+
Sbjct: 1965 LKVVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLV 2024
Query: 414 ALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQ 473
A+ + ++ + + + N Q + K +E ++D A
Sbjct: 2025 AMAVEGVVGF----LLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGDADN-- 2078
Query: 474 GKEAIRIRNVKKEYKG-KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSV 532
+ ++I N+ K YK K G++ A+ L + G+ +LG +GAGK+S +L G
Sbjct: 2079 --DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDES 2136
Query: 533 PTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVE 592
T G + ++ +++L ++++ G CPQ + FD LT +E+L L+ +++GI K+
Sbjct: 2137 TTGGEAFVNGHSV--LKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEA 2194
Query: 593 QEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
+ V+ L +L++ D A S G KRKL+ I ++G P + LDEPTTG+DP +R
Sbjct: 2195 RVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRF 2254
Query: 653 VWSLLRER-RADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLS 711
+W+L+ + + ++ ++ SM+E + L R IM NGRL+C GS LK R+G GY ++
Sbjct: 2255 LWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMIT 2314
Query: 712 LHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSD-QG 770
+ + + + F + P+A LK + K+ Y L E + +FS +++ S G
Sbjct: 2315 VRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLG 2373
Query: 771 VTGYDISMSTLNEVFMKLEGQSTIEQDFEQVE 802
+ Y +S +TL+ VF+ + + + ++ E
Sbjct: 2374 IEDYSVSQTTLDNVFVNFAKKQSDNLEQQETE 2405
Score = 154 bits (388), Expect = 9e-37
Identities = 104/353 (29%), Positives = 176/353 (49%), Gaps = 34/353 (9%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------C 1349
K KK+A +S + E +++ LG NGAGK++++ +++G+ PT+G + G
Sbjct: 1031 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090
Query: 1350 SSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVP 1409
+ +LG CPQ NVL+ LT+ EHL Y+ +K + + + R + +++ +L + +
Sbjct: 1091 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1150
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
VQ L+ G+ RKL ++ +G S ++LDEP+ G+DP ++ +W I + R +LL+
Sbjct: 1151 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI--LKYKPGRTILLS 1208
Query: 1470 THNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILK 1529
TH++ EA+ L DR+AI+ G+L+C GS LK G Y L L + +
Sbjct: 1209 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1268
Query: 1530 LFPQAAGQERYSSL----------------------LTYKLP--VADVYPLSQTFHKLEA 1565
P A S L L+Y LP A + F LE
Sbjct: 1269 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1328
Query: 1566 VKHNFNLEEYSLSQCTLEKVFLELSKE-QEVGNFDEEIDTTMRWKLLPHSDEP 1617
+L + L TLE+VFL++S+E Q + N + ++ + R +LP ++ P
Sbjct: 1329 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKES-RKDVLPGAEGP 1380
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 276 bits (707), Expect = 9e-74
Identities = 192/690 (27%), Positives = 336/690 (48%), Gaps = 87/690 (12%)
Query: 174 GFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF------ITKNLLHNEMFILFF 227
GF LQ + AII + T T + M+ +P+ I ++ M +
Sbjct: 592 GFAYLQDVVEQAIIRVLTGTE------KKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMT 645
Query: 228 LLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIIT 287
L + I V ++ + K M++MGL +S W SW + + + + + +I+
Sbjct: 646 LAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILK 705
Query: 288 FTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLV--VFLLTLFWGCLGFT 345
++ + V+F+ ++ + + FL+S L +A L + TL+ +
Sbjct: 706 LGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCV 765
Query: 346 VFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV----IFPDP-SGDSYTMIATF 400
+ + + +L+ ++ SP AF G + GV +F P D + + +
Sbjct: 766 AWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSV 825
Query: 401 SMLLLDGLIYLLLALYFDKILP--YGDERHY-----SPLFFLNSSSCFQHQRTNAKVIEK 453
SM+L D +Y ++ Y + + P YG R + +F S H +N K I +
Sbjct: 826 SMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISE 885
Query: 454 EIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAIL 513
E P+ K + I+N+ K Y+ G A+ GL + YEGQIT+ L
Sbjct: 886 ICMEEEPT-----------HLKLGVSIQNLVKVYR--DGMKVAVDGLALNFYEGQITSFL 932
Query: 514 GHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTV 573
GH+GAGK++ ++IL GL PT G+ I K++ ++ IR+ GVCPQ NV FD+LTV
Sbjct: 933 GHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS--EMSTIRQNLGVCPQHNVLFDMLTV 990
Query: 574 KENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQ-DNLAKHLSEGQKRKLTFGITILGD 632
+E++ +A++KG+ K V+ E++++ L++ + + + + LS G +RKL+ + +G
Sbjct: 991 EEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGG 1050
Query: 633 PQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLK 692
++++LDEPT G+DP+SR +W LL + R I+ ST MDEAD+L DR I+S+G+L
Sbjct: 1051 SKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLC 1110
Query: 693 CAGSSMFLKRRWGLGYHLSLHRNEI----------------------------------- 717
C GSS+FLK + G GY+L+L + ++
Sbjct: 1111 CVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSD 1170
Query: 718 -------CNPEQITSFITHHIPDAKLKTENKEKLVYTLPLE--RTNTFPDLFSDL-DKCS 767
+ I++ I H+ +A+L + +L Y LP E + F +LF ++ D+ S
Sbjct: 1171 HESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLS 1230
Query: 768 DQGVTGYDISMSTLNEVFMKLEGQSTIEQD 797
D G++ Y IS +TL E+F+K+ +S ++ +
Sbjct: 1231 DLGISSYGISETTLEEIFLKVAEESGVDAE 1260
Score = 221 bits (562), Expect = 6e-57
Identities = 201/729 (27%), Positives = 342/729 (46%), Gaps = 88/729 (12%)
Query: 910 INNTES-----NIEDFIKSLKHQNILLE---VDDFENRNGTDGLSYNGAIIVSGKQKDYR 961
++NT++ + D IK +K L + D F N G ++G
Sbjct: 1539 VSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGR---------FMTGLDTKNN 1589
Query: 962 FSVVCNTKRLHCFPILMNIISNGLL----QMFNHTQHIRIESSPFPL-------SHIGLW 1010
V N K H +N+I+N +L Q + H I + PL S + L
Sbjct: 1590 VKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALM 1649
Query: 1011 TGLPDG--SFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSF 1068
T D S + + + + I + AK +ISG+ YW + D+
Sbjct: 1650 TTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCN 1709
Query: 1069 FILILLLMYLIFY-IENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFR-KRRKN 1126
+++ L+ +IF + Y+ T+ V AL+++ G+ S+ +Y SF+F+
Sbjct: 1710 YVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGW--SITPLMYPASFVFKIPSTAY 1767
Query: 1127 SGLWSFYFFFA-----STIMFSITLINHFD-LSILITTMVLVPSYTLLGFKTFLEVRDQ- 1179
L S F +T + + N + ++ ++ ++ L+ + LG V++Q
Sbjct: 1768 VVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQA 1827
Query: 1180 --EHYREFPEANFELSATDFLV---CFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRI 1234
+ F E F + LV F + ++F + ++ + F I
Sbjct: 1828 MADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYR-----------FFI 1876
Query: 1235 SPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILD---EKPVIIASCLHKEYAGQKK 1291
P+ +AK +P DEDED++ ER R ILD + ++ L K Y
Sbjct: 1877 RPRPVNAKLSPLN--DEDEDVRRERQR--------ILDGGGQNDILEIKELTKIY----- 1921
Query: 1292 SCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCS- 1350
+RK+K A I + GE GLLG NGAGKSS+ +M++G T T G+ L S
Sbjct: 1922 ----RRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSI 1977
Query: 1351 -----SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQ 1405
V ++GYCPQ + + +LT REH+E +A ++G+ + + + L +
Sbjct: 1978 LSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKY 2037
Query: 1406 LNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERG 1465
+ G RKL ++L+G PV+ LDEP+TG+DP ++ +W +VVK R
Sbjct: 2038 GEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEG-RS 2096
Query: 1466 VLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHT 1525
V+LT+H++ E EALC R+AIMV+GR RC+GS+QHLKN+ G Y + +++ ++
Sbjct: 2097 VVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQ 2156
Query: 1526 EILKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEK 1584
+ L FP + +E++ ++L Y+LP + + L++ F L K ++E+YS+SQ TL++
Sbjct: 2157 DFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQ 2215
Query: 1585 VFLELSKEQ 1593
VF+ +K+Q
Sbjct: 2216 VFVNFAKDQ 2224
Score = 176 bits (446), Expect = 2e-43
Identities = 166/645 (25%), Positives = 301/645 (46%), Gaps = 80/645 (12%)
Query: 178 LQTAINTAIIEITT-NHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVY 236
LQ N + IT NHP +++T + + +T ++ + F + F P +
Sbjct: 1618 LQKGENPSHYGITAFNHP-----LNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASF 1672
Query: 237 FISLNVTKERKKSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQ--I 291
+ L + + K+K+L + G++ +WLS W + ++ ++ + I I F Q
Sbjct: 1673 VVFL-IQERVSKAKHLQFISGVKPVIYWLSNFVWDM--CNYVVPATLVIIIFICFQQKSY 1729
Query: 292 IVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY--- 348
+ T V+ +L LYG S+ L++ S + K +V+ + LF G G +
Sbjct: 1730 VSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLE 1789
Query: 349 -------EQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVI------FPDPSGDSYT 395
+ L+ + I F G+I ++K + + F P
Sbjct: 1790 LFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLV 1849
Query: 396 MIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEI 455
F+M + +G+++ L+ + ++ Y FF+ + NAK+
Sbjct: 1850 GRNLFAMAV-EGVVFFLITV----LIQYR--------FFIRP------RPVNAKL----- 1885
Query: 456 DAEHPSDDYFEPVAPEFQG-------KEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQ 508
P +D E V E Q + + I+ + K Y+ K + A+ + I G+
Sbjct: 1886 ---SPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRK--RKPAVDRICVGIPPGE 1940
Query: 509 ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQF 568
+LG +GAGKSS +L G + T G + NKN S + ++ E+ + G CPQF+
Sbjct: 1941 CFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL-NKN-SILSNIHEVHQNMGYCPQFDAIT 1998
Query: 569 DILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGIT 628
++LT +E++ FA ++G+ KEV + + + +L + + A + S G KRKL+ +
Sbjct: 1999 ELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMA 2058
Query: 629 ILGDPQILLLDEPTTGLDPFSRDQVW----SLLRERRADHVILFSTQSMDEADILADRKV 684
++G P ++ LDEPTTG+DP +R +W S+++E R+ ++ ++ SM+E + L R
Sbjct: 2059 LIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRS---VVLTSHSMEECEALCTRMA 2115
Query: 685 IMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPE--QITSFITHHIPDAKLKTENKE 742
IM NGR +C GS LK R+G GY + + R NP+ + F P + LK +++
Sbjct: 2116 IMVNGRFRCLGSVQHLKNRFGDGYTIVV-RIAGSNPDLKPVQDFFGLAFPGSVLKEKHRN 2174
Query: 743 KLVYTLPLERTNTFPDLFSDLDKCSDQ-GVTGYDISMSTLNEVFM 786
L Y LP ++ +FS L + + + Y +S +TL++VF+
Sbjct: 2175 MLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
Score = 164 bits (414), Expect = 8e-40
Identities = 165/691 (23%), Positives = 297/691 (42%), Gaps = 95/691 (13%)
Query: 974 FPILMNIISNGLLQMFNHTQH---IRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPY 1030
F L +++ ++++ T+ + ++ P+P ++ + S LF+ L I
Sbjct: 593 FAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSV 652
Query: 1031 --ITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYL 1088
I G + + + K + I GL S W +S I +L+ L+ I + L
Sbjct: 653 AVIIKGIVYEKEARLKETMRIMGLDNSILWFSWF---ISSLIPLLVSAGLLVVILKLGNL 709
Query: 1089 LITSQ--IVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSF-YFFFASTIMFSIT 1145
L S +VF + V +A + ++IS +F + + YF + +
Sbjct: 710 LPYSDPSVVFVFLSV---FAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVA 766
Query: 1146 LINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQ------EHYREFP--EANFELSATDF 1197
++ ++ I +L P G + F +Q ++ E P E F L+ +
Sbjct: 767 WQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVS 826
Query: 1198 LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRIS--PQSRDAKPNPEEPIDEDEDI 1255
++ F + ++ ++ + G R P + + D K +P +I
Sbjct: 827 MMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEI 886
Query: 1256 QTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEI 1315
E T L SI + L K Y + K+A ++ EG+I
Sbjct: 887 CMEEEPTHLKLGVSIQN---------LVKVY---------RDGMKVAVDGLALNFYEGQI 928
Query: 1316 LGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGHLGYCPQENVLWPML 1369
LG NGAGK++++ +++G+ PT+G + G S++ +LG CPQ NVL+ ML
Sbjct: 929 TSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDML 988
Query: 1370 TLREHLEVYAAVKGLRKADARLAIARLVSAFKL-HEQLNVPVQKLTAGITRKLCFVLSLL 1428
T+ EH+ YA +KGL + + + ++ L +L +L+ G+ RKL L+ +
Sbjct: 989 TVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFV 1048
Query: 1429 GNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVS 1488
G S V++LDEP+ G+DP ++ +W+ + + R ++L+TH++ EA+ L DR+AI+
Sbjct: 1049 GGSKVVILDEPTAGVDPYSRRGIWELLLKYRQG--RTIILSTHHMDEADVLGDRIAIISH 1106
Query: 1489 GRLRCIGSIQHLKNKLGKDYILELKVKE-------------------------------- 1516
G+L C+GS LKN+LG Y L L K+
Sbjct: 1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAG 1166
Query: 1517 ----------TSQVTLVHTEILKLFPQAAGQERYSSLLTYKLP--VADVYPLSQTFHKLE 1564
T V+ + I K +A E LTY LP A + FH+++
Sbjct: 1167 LGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEID 1226
Query: 1565 AVKHNFNLEEYSLSQCTLEKVFLELSKEQEV 1595
+ + Y +S+ TLE++FL++++E V
Sbjct: 1227 DRLSDLGISSYGISETTLEEIFLKVAEESGV 1257
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 270 bits (690), Expect = 8e-72
Identities = 204/746 (27%), Positives = 360/746 (48%), Gaps = 64/746 (8%)
Query: 171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLH 230
+ R F+ LQ +I AIIE+ T E + V AI F+ N L + + L +L
Sbjct: 699 YGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPC--FMKDNFLTSVSYSLPIVLM 756
Query: 231 FSPLVY---FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIIT 287
+ +V+ F+ V ++ + MKMMG+ + + +W + GF+ + + + II+
Sbjct: 757 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 816
Query: 288 FTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTL--FWGCLGFT 345
F I+ T ++F+ F Y S++A+ +L+SV + L+ L+ + F+ +
Sbjct: 817 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 876
Query: 346 VFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV----IFPDPSGDSYTMIATFS 401
+L L+ +++ SP AF+ I + + G+ ++ P D T
Sbjct: 877 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 936
Query: 402 MLLL-DGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKV---------- 450
L+L D IY L+A Y + P G +P +F S ++ + A+V
Sbjct: 937 CLILADSFIYFLIAWYVRNVFP-GTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMF 995
Query: 451 ----IEKEIDAEHPSDDYFEPVAPEFQGKEA-IRIRNVKKEYKGKSGKVEALKGLLFDIY 505
++ + P + + PE + + + V K Y G A+ L + Y
Sbjct: 996 TNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY----GSKVAVDNLNLNFY 1051
Query: 506 EGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFN 565
EG IT++LG +GAGK++ +++L GL + G++ +Y K++ DL +RK GVC Q +
Sbjct: 1052 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQHD 1109
Query: 566 VQFDILTVKENLSLFAKIKGIHL--KEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKL 623
V F LT KE+L L+ IK H K++ +EV+R L + + + + LS G KRKL
Sbjct: 1110 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1169
Query: 624 TFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRK 683
+ I ++G ++++LDEP+TG+DP SR +W ++ + + I+ ST +DEA++L+DR
Sbjct: 1170 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1229
Query: 684 VIMSNGRLKCAGSSMFLKRRWGLGYHL--------SLHRNEICNPEQITSFITHHIPDAK 735
+ G L+C GS +LK +G GYHL +L+ N +C+ +T+ I H+P+A
Sbjct: 1230 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1289
Query: 736 LKTENKEKLVYTLP---LERTNTFPDLFSDLDK-CSDQGVTGYDISMSTLNEVFMKL--E 789
LK + +LVY LP + + + L LD D + Y IS +T+ EVF+ L E
Sbjct: 1290 LKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKE 1349
Query: 790 GQSTIEQDFEQVEMIRDSES-------LNEMELAHSSFSEMQTAV-------SDMGLWRM 835
Q E + + S +++ ++ S+F++ + GL
Sbjct: 1350 SQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLK 1409
Query: 836 QVFAMARLRFLKLKRQTKVLLTLLLV 861
++ A+ RF +R K L+ +++
Sbjct: 1410 KIMAILIKRFHHTRRNWKGLIAQVIL 1435
Score = 231 bits (588), Expect = 6e-60
Identities = 189/668 (28%), Positives = 318/668 (47%), Gaps = 77/668 (11%)
Query: 972 HCFPILMNIISNGLLQM----FNHTQH-IRIESSPFPLSHIGLWTGLPD------GSFFL 1020
H P +N ++N LL++ ++ +H I + S P+P G+ D S
Sbjct: 1617 HSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--------GVQDQEQATISSLID 1668
Query: 1021 FLVLCSI--------SPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFI-- 1070
LV SI + ++T + +++ AK ISG+ + YW + D+ F++
Sbjct: 1669 ILVALSILMGYSVTTASFVTY-VVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVP 1727
Query: 1071 ------LILLLMYLIFYIEN-----MQYLLITSQIVFALVIVTPG--YAASLVFFIYMIS 1117
+I + FY EN LL+ F+ + + G + + F Y+
Sbjct: 1728 VAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCV 1787
Query: 1118 FIFRKRRKNSGLWSFYFFFASTIMF-SITLINHFDLSILITTMVLVPSYTLLGFKTFLEV 1176
+F L YF ++ LI+ I + Y L+ V
Sbjct: 1788 NLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSV 1847
Query: 1177 RD--QEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRI 1234
D + + E+P FE++ + + T+ F L E K R+ FR
Sbjct: 1848 LDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL----FFRK 1903
Query: 1235 SPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCF 1294
S + E IDEDED++ ER+R + E ++ CL K Y
Sbjct: 1904 FNSS-----HVRETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ------- 1946
Query: 1295 SKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLG 1354
KK IA NIS + GE GLLG NGAGK++ +M++G P++G + ++ + LG
Sbjct: 1947 LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLG 2006
Query: 1355 HL-------GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLN 1407
H+ GYCPQE+ L ++T+ EHL YA V G+ + D + + +L+ L +
Sbjct: 2007 HVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKD 2066
Query: 1408 VPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL 1467
+ G RKL L+L+G +LLLDEPS+G+DP ++ +W+ I V+N + V+
Sbjct: 2067 RATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVI 2125
Query: 1468 LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEI 1527
LT+H++ E EALC R+AIMV+G+ +CIGS+QH+K++ G+ + +++ +K T+
Sbjct: 2126 LTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKF 2185
Query: 1528 LKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVF 1586
++L FP+ ++++ S+L Y +PV ++ F LE K N+ + +SQ TLE+VF
Sbjct: 2186 MQLHFPKTYLKDQHLSMLEYHVPVT-AGGVANIFDLLETNKTALNITNFLVSQTTLEEVF 2244
Query: 1587 LELSKEQE 1594
+ +K+Q+
Sbjct: 2245 INFAKDQK 2252
Score = 195 bits (495), Expect = 3e-49
Identities = 147/577 (25%), Positives = 284/577 (49%), Gaps = 44/577 (7%)
Query: 237 FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFII----SIFVTIIITFTQII 292
F++ V + + K+K L + G+ + +W++ IY +++ SI + I
Sbjct: 1686 FVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPVAFSIGIIAIFKLPAFY 1744
Query: 293 VMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGC---LGFTVFY- 348
+ +L L+G + + ++L++ L + + + + LF+G + +V Y
Sbjct: 1745 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 1804
Query: 349 -----------EQLPSSLEWILNICSPFAFTTGMIQIIK----LDY-NLNGVIFPDPSGD 392
E + +L+ I I F F G+I++ + LD+ GV +P+ + +
Sbjct: 1805 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFE 1864
Query: 393 SYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIE 452
+ A F L+ G ++ L L ++ L LFF +S + + +
Sbjct: 1865 MNKLGAMFVALVSQGTMFFSLRLLINESLI-----KKLRLFFRKFNSSHVRETIDE---D 1916
Query: 453 KEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAI 512
+++ AE E A EF + +++ + K Y+ K+ A+ + I G+ +
Sbjct: 1917 EDVRAERLR---VESGAAEF---DLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGL 1970
Query: 513 LGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILT 572
LG +GAGK+++ +L G +P+ G++ I NK S + ++ + G CPQ + D++T
Sbjct: 1971 LGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDSHSSLVGYCPQEDALDDLVT 2029
Query: 573 VKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGD 632
V+E+L +A++ GI K++++ V ++L L + +D S G KRKL+ + ++G
Sbjct: 2030 VEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGK 2089
Query: 633 PQILLLDEPTTGLDPFSRDQVWSLLRERRADHV-ILFSTQSMDEADILADRKVIMSNGRL 691
P ILLLDEP++G+DP S+ +W ++ E + ++ ++ SM+E + L R IM NG+
Sbjct: 2090 PSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKF 2149
Query: 692 KCAGSSMFLKRRWGLGYHLSLH-RNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPL 750
+C GS +K R+G G+ + +H +N E +T F+ H P LK ++ L Y +P+
Sbjct: 2150 QCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPV 2209
Query: 751 ERTNTFPDLFSDLD-KCSDQGVTGYDISMSTLNEVFM 786
++F L+ + +T + +S +TL EVF+
Sbjct: 2210 -TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2245
Score = 162 bits (411), Expect = 2e-39
Identities = 106/314 (33%), Positives = 167/314 (53%), Gaps = 21/314 (6%)
Query: 1300 KIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVL 1353
K+A N++ EG I LLGPNGAGK+++I M++G+ +AG + + G +V
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVR 1099
Query: 1354 GHLGYCPQENVLWPMLTLREHLEVYAAVK--GLRKADARLAIARLVSAFKLHEQLNVPVQ 1411
++G C Q +VL+ LT +EHL +Y ++K K + R + L+ + V
Sbjct: 1100 KNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVG 1159
Query: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
L+ G+ RKL ++L+G S V++LDEPSTG+DP ++ +W I T R ++L+TH
Sbjct: 1160 TLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK--NKTARTIILSTH 1217
Query: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQV-------TLVH 1524
+L EAE L DR+A + G LRC GS +LK G Y L L K++ + T+
Sbjct: 1218 HLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAV 1277
Query: 1525 TEILKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKH---NFNLEEYSLSQC 1580
T +++ P+A +E L Y LP L A+ + + N+ Y +S
Sbjct: 1278 TAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDT 1337
Query: 1581 TLEKVFLELSKEQE 1594
T+E+VFL L+KE +
Sbjct: 1338 TVEEVFLNLTKESQ 1351
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 270 bits (690), Expect = 8e-72
Identities = 204/746 (27%), Positives = 360/746 (48%), Gaps = 64/746 (8%)
Query: 171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLH 230
+ R F+ LQ +I AIIE+ T E + V AI F+ N L + + L +L
Sbjct: 1017 YGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPC--FMKDNFLTSVSYSLPIVLM 1074
Query: 231 FSPLVY---FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIIT 287
+ +V+ F+ V ++ + MKMMG+ + + +W + GF+ + + + II+
Sbjct: 1075 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
Query: 288 FTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTL--FWGCLGFT 345
F I+ T ++F+ F Y S++A+ +L+SV + L+ L+ + F+ +
Sbjct: 1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
Query: 346 VFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV----IFPDPSGDSYTMIATFS 401
+L L+ +++ SP AF+ I + + G+ ++ P D T
Sbjct: 1195 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 1254
Query: 402 MLLL-DGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKV---------- 450
L+L D IY L+A Y + P G +P +F S ++ + A+V
Sbjct: 1255 CLILADSFIYFLIAWYVRNVFP-GTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMF 1313
Query: 451 ----IEKEIDAEHPSDDYFEPVAPEFQGKEA-IRIRNVKKEYKGKSGKVEALKGLLFDIY 505
++ + P + + PE + + + V K Y G A+ L + Y
Sbjct: 1314 TNIMMQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIY----GSKVAVDNLNLNFY 1369
Query: 506 EGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFN 565
EG IT++LG +GAGK++ +++L GL + G++ +Y K++ DL +RK GVC Q +
Sbjct: 1370 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQHD 1427
Query: 566 VQFDILTVKENLSLFAKIKGIHL--KEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKL 623
V F LT KE+L L+ IK H K++ +EV+R L + + + + LS G KRKL
Sbjct: 1428 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1487
Query: 624 TFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRK 683
+ I ++G ++++LDEP+TG+DP SR +W ++ + + I+ ST +DEA++L+DR
Sbjct: 1488 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1547
Query: 684 VIMSNGRLKCAGSSMFLKRRWGLGYHL--------SLHRNEICNPEQITSFITHHIPDAK 735
+ G L+C GS +LK +G GYHL +L+ N +C+ +T+ I H+P+A
Sbjct: 1548 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1607
Query: 736 LKTENKEKLVYTLP---LERTNTFPDLFSDLDK-CSDQGVTGYDISMSTLNEVFMKL--E 789
LK + +LVY LP + + + L LD D + Y IS +T+ EVF+ L E
Sbjct: 1608 LKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKE 1667
Query: 790 GQSTIEQDFEQVEMIRDSES-------LNEMELAHSSFSEMQTAV-------SDMGLWRM 835
Q E + + S +++ ++ S+F++ + GL
Sbjct: 1668 SQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLK 1727
Query: 836 QVFAMARLRFLKLKRQTKVLLTLLLV 861
++ A+ RF +R K L+ +++
Sbjct: 1728 KIMAILIKRFHHTRRNWKGLIAQVIL 1753
Score = 231 bits (588), Expect = 6e-60
Identities = 189/668 (28%), Positives = 318/668 (47%), Gaps = 77/668 (11%)
Query: 972 HCFPILMNIISNGLLQM----FNHTQH-IRIESSPFPLSHIGLWTGLPD------GSFFL 1020
H P +N ++N LL++ ++ +H I + S P+P G+ D S
Sbjct: 1935 HSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--------GVQDQEQATISSLID 1986
Query: 1021 FLVLCSI--------SPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFI-- 1070
LV SI + ++T + +++ AK ISG+ + YW + D+ F++
Sbjct: 1987 ILVALSILMGYSVTTASFVTY-VVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVP 2045
Query: 1071 ------LILLLMYLIFYIEN-----MQYLLITSQIVFALVIVTPG--YAASLVFFIYMIS 1117
+I + FY EN LL+ F+ + + G + + F Y+
Sbjct: 2046 VAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCV 2105
Query: 1118 FIFRKRRKNSGLWSFYFFFASTIMF-SITLINHFDLSILITTMVLVPSYTLLGFKTFLEV 1176
+F L YF ++ LI+ I + Y L+ V
Sbjct: 2106 NLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSV 2165
Query: 1177 RD--QEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRI 1234
D + + E+P FE++ + + T+ F L E K R+ FR
Sbjct: 2166 LDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL----FFRK 2221
Query: 1235 SPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCF 1294
S + E IDEDED++ ER+R + E ++ CL K Y
Sbjct: 2222 FNSS-----HVRETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ------- 2264
Query: 1295 SKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLG 1354
KK IA NIS + GE GLLG NGAGK++ +M++G P++G + ++ + LG
Sbjct: 2265 LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLG 2324
Query: 1355 HL-------GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLN 1407
H+ GYCPQE+ L ++T+ EHL YA V G+ + D + + +L+ L +
Sbjct: 2325 HVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKD 2384
Query: 1408 VPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL 1467
+ G RKL L+L+G +LLLDEPS+G+DP ++ +W+ I V+N + V+
Sbjct: 2385 RATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSVI 2443
Query: 1468 LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEI 1527
LT+H++ E EALC R+AIMV+G+ +CIGS+QH+K++ G+ + +++ +K T+
Sbjct: 2444 LTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKF 2503
Query: 1528 LKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVF 1586
++L FP+ ++++ S+L Y +PV ++ F LE K N+ + +SQ TLE+VF
Sbjct: 2504 MQLHFPKTYLKDQHLSMLEYHVPVT-AGGVANIFDLLETNKTALNITNFLVSQTTLEEVF 2562
Query: 1587 LELSKEQE 1594
+ +K+Q+
Sbjct: 2563 INFAKDQK 2570
Score = 195 bits (495), Expect = 3e-49
Identities = 147/577 (25%), Positives = 284/577 (49%), Gaps = 44/577 (7%)
Query: 237 FISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFII----SIFVTIIITFTQII 292
F++ V + + K+K L + G+ + +W++ IY +++ SI + I
Sbjct: 2004 FVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPVAFSIGIIAIFKLPAFY 2062
Query: 293 VMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGC---LGFTVFY- 348
+ +L L+G + + ++L++ L + + + + LF+G + +V Y
Sbjct: 2063 SENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYF 2122
Query: 349 -----------EQLPSSLEWILNICSPFAFTTGMIQIIK----LDY-NLNGVIFPDPSGD 392
E + +L+ I I F F G+I++ + LD+ GV +P+ + +
Sbjct: 2123 LSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFE 2182
Query: 393 SYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIE 452
+ A F L+ G ++ L L ++ L LFF +S + + +
Sbjct: 2183 MNKLGAMFVALVSQGTMFFSLRLLINESLI-----KKLRLFFRKFNSSHVRETIDE---D 2234
Query: 453 KEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAI 512
+++ AE E A EF + +++ + K Y+ K+ A+ + I G+ +
Sbjct: 2235 EDVRAERLR---VESGAAEF---DLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGL 2288
Query: 513 LGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILT 572
LG +GAGK+++ +L G +P+ G++ I NK S + ++ + G CPQ + D++T
Sbjct: 2289 LGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS-LGHVDSHSSLVGYCPQEDALDDLVT 2347
Query: 573 VKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGD 632
V+E+L +A++ GI K++++ V ++L L + +D S G KRKL+ + ++G
Sbjct: 2348 VEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGK 2407
Query: 633 PQILLLDEPTTGLDPFSRDQVWSLLRERRADHV-ILFSTQSMDEADILADRKVIMSNGRL 691
P ILLLDEP++G+DP S+ +W ++ E + ++ ++ SM+E + L R IM NG+
Sbjct: 2408 PSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKF 2467
Query: 692 KCAGSSMFLKRRWGLGYHLSLH-RNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPL 750
+C GS +K R+G G+ + +H +N E +T F+ H P LK ++ L Y +P+
Sbjct: 2468 QCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPV 2527
Query: 751 ERTNTFPDLFSDLD-KCSDQGVTGYDISMSTLNEVFM 786
++F L+ + +T + +S +TL EVF+
Sbjct: 2528 -TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2563
Score = 162 bits (411), Expect = 2e-39
Identities = 106/314 (33%), Positives = 167/314 (53%), Gaps = 21/314 (6%)
Query: 1300 KIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVL 1353
K+A N++ EG I LLGPNGAGK+++I M++G+ +AG + + G +V
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVR 1417
Query: 1354 GHLGYCPQENVLWPMLTLREHLEVYAAVK--GLRKADARLAIARLVSAFKLHEQLNVPVQ 1411
++G C Q +VL+ LT +EHL +Y ++K K + R + L+ + V
Sbjct: 1418 KNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVG 1477
Query: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
L+ G+ RKL ++L+G S V++LDEPSTG+DP ++ +W I T R ++L+TH
Sbjct: 1478 TLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK--NKTARTIILSTH 1535
Query: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQV-------TLVH 1524
+L EAE L DR+A + G LRC GS +LK G Y L L K++ + T+
Sbjct: 1536 HLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAV 1595
Query: 1525 TEILKL-FPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKH---NFNLEEYSLSQC 1580
T +++ P+A +E L Y LP L A+ + + N+ Y +S
Sbjct: 1596 TAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDT 1655
Query: 1581 TLEKVFLELSKEQE 1594
T+E+VFL L+KE +
Sbjct: 1656 TVEEVFLNLTKESQ 1669
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 267 bits (682), Expect = 7e-71
Identities = 183/642 (28%), Positives = 330/642 (51%), Gaps = 76/642 (11%)
Query: 217 LLHNEMFILFFLLHFSPLVYFISLNVT----KERKKSKNLMKMMGLQDSAFWLSWGLIYA 272
++ N F +F +L + +Y +S+ V ++ + K +K G+ ++ W +W L
Sbjct: 649 IILNRCFPIFMVLAW---IYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSF 705
Query: 273 GFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLV- 331
+ + +TI I +I+ + ++F+ + + + L FL+S KA L
Sbjct: 706 SIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACS 765
Query: 332 -VFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPD-- 388
V TL+ + + +++ + L+ +++ SP AF G +++ + G+ + +
Sbjct: 766 GVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIG 825
Query: 389 ---PSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCF---- 441
GD ++ + + M+LLD +Y LLA Y D++ P GD P +FL S +
Sbjct: 826 NSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFP-GDYGTPLPWYFLLQESYWLGGE 884
Query: 442 ----QHQRTNAK---VIEKEIDAEHPS---DDYFEPVAPEFQGKEAIRIRNVKKEYKGKS 491
+ +R K + E+ D EHP D +FE P + + ++N+ K ++
Sbjct: 885 GCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWV--PGVCVKNLVKIFE-PC 941
Query: 492 GKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDL 551
G+ A+ L YE QITA LGH+GAGK++ L+IL GL PT G+V + +++ L
Sbjct: 942 GR-PAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET--SL 998
Query: 552 EEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNL 611
+ +R+ G+CPQ N+ F LTV E++ +A++KG +E + E++ +L + + + ++
Sbjct: 999 DAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEE 1058
Query: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQ 671
A+ LS G +RKL+ I +GD ++++LDEPT+G+DP+SR +W LL + R+ I+ ST
Sbjct: 1059 AQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTH 1118
Query: 672 SMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN---------------- 715
MDEAD+L DR I++ GRL C+G+ +FLK +G G +L+L R
Sbjct: 1119 HMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCS 1178
Query: 716 --------------EICNPEQI--------TSFITHHIPDAKLKTENKEKLVYTLPLE-- 751
+ PEQ+ + HH+P+AKL ++L++ LP +
Sbjct: 1179 CSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNF 1238
Query: 752 RTNTFPDLFSDLDK-CSDQGVTGYDISMSTLNEVFMKLEGQS 792
+ + LF +L++ +D G++ + IS + L E+F+K+ S
Sbjct: 1239 KHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDS 1280
Score = 196 bits (498), Expect = 2e-49
Identities = 121/364 (33%), Positives = 200/364 (54%), Gaps = 29/364 (7%)
Query: 1241 AKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKK 1300
A+P E +DED+D+ ER R T ++ ++ L K Y G
Sbjct: 1907 AEPTKEPIVDEDDDVAEERQRIITGG-----NKTDILRLHELTKIYPGTSSP-------- 1953
Query: 1301 IAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLG 1354
A + V+ GE GLLG NGAGK+++ +M++G T T+G+ + G S V
Sbjct: 1954 -AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQ 2012
Query: 1355 HLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLT 1414
++GYCPQ + + +LT REHL +YA ++G+ + + + L + +
Sbjct: 2013 NMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYS 2072
Query: 1415 AGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLA 1474
G RKL ++L+G P++LLDEP+TG+DP ++ +W I ++++ R V+LT+H++
Sbjct: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVVLTSHSME 2131
Query: 1475 EAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTL-----VHTEILK 1529
E EALC R+AIMV G RC+G+IQHLK+K G YI+ +K+K L V
Sbjct: 2132 ECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQG 2191
Query: 1530 LFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLEL 1589
FP + +ER+ ++L +++ + L++ F L + K + +EEYS++Q TL++VF+
Sbjct: 2192 NFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF 2248
Query: 1590 SKEQ 1593
+K+Q
Sbjct: 2249 AKQQ 2252
Score = 157 bits (398), Expect = 6e-38
Identities = 150/642 (23%), Positives = 295/642 (45%), Gaps = 79/642 (12%)
Query: 195 VMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMK 254
V+ + +++T + + +T ++ + F + F P + + L + + KSK+L
Sbjct: 1656 VISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYL-IQERVNKSKHLQF 1714
Query: 255 MMGLQDSAFWLS---WGL----IYAGFIFIISIFVTI----------IITFTQIIVMTGF 297
+ G+ + +W++ W + + AG + + IF+ + ++++ G+
Sbjct: 1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLV--VGIFIGFQKKAYTSPENLPALVALLLLYGW 1772
Query: 298 MVIFILF---FLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSS 354
VI +++ FL+ + A V L L + ++ + F+L LF F +
Sbjct: 1773 AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFN----AV 1828
Query: 355 LEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDS-----YTMIA-TFSMLLLDGL 408
L +L + F G+I + L + V S + +I ++++G+
Sbjct: 1829 LRKLLIVFPHFCLGRGLIDLA-LSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGV 1887
Query: 409 IYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPV 468
+Y LL L +RH FFL+ + + T +++++ D + +
Sbjct: 1888 VYFLLTLLV--------QRH----FFLSQ---WIAEPTKEPIVDEDDDVAEER----QRI 1928
Query: 469 APEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILN 528
+ +R+ + K Y G S A+ L + G+ +LG +GAGK++ +L
Sbjct: 1929 ITGGNKTDILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLT 1986
Query: 529 GLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHL 588
G + T G T+ K++ + ++ E+ + G CPQF+ ++LT +E+L L+A+++G+
Sbjct: 1987 GDTTVTSGDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPA 2044
Query: 589 KEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPF 648
+E+E+ + L + D LA S G KRKL+ I ++G P ++LLDEPTTG+DP
Sbjct: 2045 EEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQ 2104
Query: 649 SRDQVW----SLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRW 704
+R +W S++RE RA ++ ++ SM+E + L R IM G +C G+ LK ++
Sbjct: 2105 ARRMLWNVIVSIIREGRA---VVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKF 2161
Query: 705 GLGYHLSLHRNEICNPEQ--------ITSFITHHIPDAKLKTENKEKLVYTLPLER-TNT 755
G GY +++ +I +P+ + F + P + + + L + +
Sbjct: 2162 GDGYIVTM---KIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARI 2218
Query: 756 FPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQD 797
F L S D + Y ++ +TL++VF+ Q T D
Sbjct: 2219 FQLLLSHKDSLL---IEEYSVTQTTLDQVFVNFAKQQTESHD 2257
Score = 145 bits (365), Expect = 4e-34
Identities = 98/344 (28%), Positives = 170/344 (49%), Gaps = 62/344 (18%)
Query: 1305 NISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGHLGY 1358
NI+F E +I LG NGAGK++++ +++G+ PT+G V + G +V LG
Sbjct: 950 NITF--YENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGM 1007
Query: 1359 CPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGIT 1418
CPQ N+L+ LT+ EH+ YA +KG + +A+L + ++ LH + N Q L+ G+
Sbjct: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQ 1067
Query: 1419 RKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEA 1478
RKL ++ +G++ V++LDEP++G+DP ++ +W + + + R ++++TH++ EA+
Sbjct: 1068 RKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL--LKYRSGRTIIMSTHHMDEADL 1125
Query: 1479 LCDRVAIMVSGRLRCIGSIQHLKNKLG--------------------------------- 1505
L DR+AI+ GRL C G+ LKN G
Sbjct: 1126 LGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFS 1185
Query: 1506 -----------KDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADV- 1553
+ +L+ V E V L H KL + GQE L + LP +
Sbjct: 1186 TTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLV-ECIGQE-----LIFLLPNKNFK 1239
Query: 1554 -YPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVG 1596
+ F +LE + L + +S LE++FL+++++ + G
Sbjct: 1240 HRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 259 bits (663), Expect = 1e-68
Identities = 217/743 (29%), Positives = 347/743 (46%), Gaps = 82/743 (11%)
Query: 171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLH 230
+N F LQ I AII + T +E A P T +L N + F L+
Sbjct: 3520 YNYVFAPLQDMIERAIILVQTGQEALEPAAQTQAAPY---PCHTSDLFLNNVGFFFPLIM 3576
Query: 231 FSPLVYFISLNVTK----ERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIII 286
+ ++ V K + + + M+MMG+ +L+W L + I S + I++
Sbjct: 3577 MLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVL 3636
Query: 287 TFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKA---VLTNLVVFLLTLFWGCLG 343
+ I + ++F+ +G+S+V L +L+S +A L +V++++ F +
Sbjct: 3637 KTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMIS-FLPYIV 3695
Query: 344 FTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFS-- 401
V + QL + L + S AF G+ I L+ G+ + + TF
Sbjct: 3696 LLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWV 3755
Query: 402 --MLLLDGLIYLLLALYFDKILP--YG---------------------DERHY---SPLF 433
M+L D +Y L Y ++P +G ++R Y S LF
Sbjct: 3756 CWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLF 3815
Query: 434 FLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGK 493
F N + F ++ ++ + E E++ P + + +V KEY+G
Sbjct: 3816 FFNEN--FDNKGSSLQNREGELEGSAPG----------------VTLVSVTKEYEGHKAV 3857
Query: 494 VEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEE 553
V+ L Y QITA+LG +GAGK++++++L GL PT G++ I KNL DL
Sbjct: 3858 VQDLS---LTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQT--DLSR 3912
Query: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHL--KEVEQEVQRILLELDMQNIQDNL 611
+R GVCPQ ++ D LTV+E+L LFA IK KE+ Q+V + L ++D+ Q
Sbjct: 3913 VRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQ 3972
Query: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQ 671
+ LS G KRKL+ GI +G + ++LDEPT+G+DP SR +W +L + R I+F+T
Sbjct: 3973 TRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTH 4032
Query: 672 SMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHR-------NEICNPEQIT 724
+DEA+ L+DR ++ +GRL+C G LK +G G L+L R +++ + +T
Sbjct: 4033 HLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVT 4092
Query: 725 SFITHHIPDAKLKTENKEKLVYTLPLERTNT-FPDLFSDLDKCSDQ-GVTGYDISMSTLN 782
S I +IP A LK + +L YT+P + LF LD+ Q +TGY IS +TL
Sbjct: 4093 SLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLE 4152
Query: 783 EVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSS----FSEMQTAVSDMGLWRMQVF 838
EVF+ L S + + + +SE N H S V + L R QV
Sbjct: 4153 EVFLMLLQDSNKK---SHIALGTESELQNHRPTGHLSGYCGSLARPATVQGVQLLRAQVA 4209
Query: 839 AMARLRFLKLKRQTKVLLTLLLV 861
A+ R + R K L LL+
Sbjct: 4210 AILARRLRRTLRAGKSTLADLLL 4232
Score = 184 bits (466), Expect = 8e-46
Identities = 109/305 (35%), Positives = 172/305 (56%), Gaps = 13/305 (4%)
Query: 1301 IAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGE----------VELKGCS 1350
IA ++IS + +GE GLLG NGAGKS++ +M++G T+G V+L
Sbjct: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAG 4794
Query: 1351 SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPV 1410
+ +GYCPQ++ L +LT EHL Y +++G+ + L+ L + PV
Sbjct: 4795 TAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPV 4854
Query: 1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTT 1470
+ G RKL L+L+G +LLLDEPS+G+DP ++ +WQ I V+ V LT+
Sbjct: 4855 ATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAV-LTS 4913
Query: 1471 HNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV-KETSQVTLVHTEILK 1529
H++ E EALC R+AIMV+G +C+GS QH+KN+ G Y +++ + KE +Q V +
Sbjct: 4914 HSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLKL 4973
Query: 1530 LFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLEL 1589
FP + ++ +LL Y +P L+ F +E K N++ YS++Q TLE+VF+
Sbjct: 4974 YFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINF 5032
Query: 1590 SKEQE 1594
+ EQ+
Sbjct: 5033 ASEQQ 5037
Score = 168 bits (425), Expect = 4e-41
Identities = 155/570 (27%), Positives = 264/570 (46%), Gaps = 70/570 (12%)
Query: 1074 LLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA---SLVFFIYMISF------------ 1118
++ +L +++ENM L I+S + A+V+ T G A + + F++++ F
Sbjct: 3611 VIHFLAWFLENMAVLTISSATL-AIVLKTSGIFAHSNTFIVFLFLLDFGMSVVMLSYLLS 3669
Query: 1119 IFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLG----FKTFL 1174
F + + L + + S + + + L+ H LS + T + + S T G F TFL
Sbjct: 3670 AFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFL 3729
Query: 1175 EVRDQE-HYREFPEANFELSATDFLVCFIPYFQT-LLFVFVLRCMELKCGKKRMRKDPVF 1232
E ++ + +A + T VC++ F + L F+ L G +RK F
Sbjct: 3730 EGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYF 3789
Query: 1233 RISPQSRDAKPNPEEP-----------IDEDEDIQTERIRTATALTTSILDEKPVIIASC 1281
+ + E +E+ D + ++ + P +
Sbjct: 3790 PFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREG---ELEGSAPGVTLVS 3846
Query: 1282 LHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA 1341
+ KEY G K +++S +I LLG NGAGK++ I M++G+ PT+
Sbjct: 3847 VTKEYEGHKA----------VVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTS 3896
Query: 1342 GEVELKG------CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLR--KADARLAI 1393
G + + G S V LG CPQ+++L LT+REHL ++A++K + K + +
Sbjct: 3897 GTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQV 3956
Query: 1394 ARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQ 1453
+ + L + + + L+ G+ RKL ++ +G S ++LDEP++G+DP + +W
Sbjct: 3957 NQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWD 4016
Query: 1454 AIQAVVKNTE-RGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL 1512
+ +K E R ++ TTH+L EAEAL DRVA++ GRLRC G LK G+ L L
Sbjct: 4017 IL---LKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQG--LRL 4071
Query: 1513 KVKETSQVTLVH--------TEILKLF-PQAAGQERYSSLLTYKLPV-ADVYPLSQTFHK 1562
+ V H T ++K++ PQA ++ S LTY +P D L F
Sbjct: 4072 TLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQA 4131
Query: 1563 LEAVKHNFNLEEYSLSQCTLEKVFLELSKE 1592
L+ H +L Y +S TLE+VFL L ++
Sbjct: 4132 LDENLHQLHLTGYGISDTTLEEVFLMLLQD 4161
Score = 156 bits (395), Expect = 1e-37
Identities = 165/679 (24%), Positives = 294/679 (43%), Gaps = 69/679 (10%)
Query: 166 TLTKYW--NRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMF 223
TL K W +GF +L + +N I H IT+ + P+ LL+ +
Sbjct: 4391 TLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPY-GGALLNKDKI 4449
Query: 224 I---------LFFLLHFSPLVYFISLNVTKERK-KSKNLMKMMGLQDSAFWLSWGLIYAG 273
+ L +L FS L I +V ++R +K L + GL +W + +Y
Sbjct: 4450 LESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFT-NFLYDM 4508
Query: 274 FIFIISIF--VTIIITF--TQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTN 329
+++S+ V +I+ F T +L L+G + + ++LMS + + +
Sbjct: 4509 LFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAF 4568
Query: 330 LVVFLLTLFWGCLGFTVFY--------------EQLPSSLEWILNICSPFAFTTGMIQI- 374
+ L +G + + + L+W+ I F G++++
Sbjct: 4569 ISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELC 4628
Query: 375 ---IKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSP 431
IK D N I DSY ++ F M L G I++ LA +L H+
Sbjct: 4629 YNQIKYDLTHNFGI------DSY--VSPFEMNFL-GWIFVQLASQGTVLLLLRVLLHWDL 4679
Query: 432 LFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKS 491
L + S Q ++K + D E FE + + + N+ K Y+
Sbjct: 4680 LRWPRGHSTLQGTVKSSK----DTDVEKEEKRVFEGRT----NGDILVLYNLSKHYRRFF 4731
Query: 492 GKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDL 551
+ A++ + I +G+ +LG +GAGKS+ +LNG T G I + + DL
Sbjct: 4732 QNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTP-MGDAVDL 4790
Query: 552 EEIRK---ITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQ 608
+ G CPQ + ++LT E+L + ++GI + + + ++ L ++
Sbjct: 4791 SSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHA 4850
Query: 609 DNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVW-SLLRERRADHVIL 667
D S G KRKL+ + ++G P ILLLDEP++G+DP S+ +W ++++E R +
Sbjct: 4851 DKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAV 4910
Query: 668 FSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL----HRNEICNPEQI 723
++ SM+E + L R IM NG KC GS +K R+G GY + + N+ C +
Sbjct: 4911 LTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCT---V 4967
Query: 724 TSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSD-QGVTGYDISMSTLN 782
+ + + P + K ++ L Y +P +R DLF ++ + Y I+ +TL
Sbjct: 4968 SDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLE 5026
Query: 783 EVFMKL--EGQSTIEQDFE 799
+VF+ E Q T++ +
Sbjct: 5027 QVFINFASEQQQTLQSTLD 5045
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 257 bits (657), Expect = 6e-68
Identities = 212/797 (26%), Positives = 366/797 (45%), Gaps = 102/797 (12%)
Query: 157 WD-GYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPF--- 212
WD G T +Y GFV LQ + A + V+ + ++ +P+
Sbjct: 484 WDPGPAADPLTDLRYVWGGFVYLQDLVERAAVR------VLSGANPRAGLYLQQMPYPCY 537
Query: 213 ---ITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGL 269
+ +L + + L + + V ++ + ++ M+ MGL + WL W L
Sbjct: 538 VDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFL 597
Query: 270 IYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLT- 328
G + + + +++ I+ + V+F+ + ++ V FL+S +A L
Sbjct: 598 SCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAA 657
Query: 329 ---NLVVFLLTL-FWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGV 384
L F L L + C+ + ++LP+ ++ SP AF G + L+ G
Sbjct: 658 ACGGLAYFSLYLPYVLCVAWR---DRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGA 714
Query: 385 IFPD----PSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGDERHYSPLFFLNSS 438
+ + P+ D +++ +LLLD +Y L Y + + P YG ++ F S
Sbjct: 715 QWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWN-FPFRRSY 773
Query: 439 SCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALK 498
C + +D + ++ ++P + +R+++K + G AL+
Sbjct: 774 WCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSP------GVSVRSLEKRFPGSPQP--ALR 825
Query: 499 GLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKIT 558
GL D Y+G ITA LGH+GAGK++ L+IL+GL P+ GS I ++ + IR
Sbjct: 826 GLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS--SMAAIRPHL 883
Query: 559 GVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEG 618
GVCPQ+NV FD+LTV E++ + ++KG+ V E R+L ++ + + Q +HLS G
Sbjct: 884 GVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGG 943
Query: 619 QKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADI 678
+RKL+ I +G Q+++LDEPT G+DP SR +W LL + R ++ ST +DEA++
Sbjct: 944 MQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAEL 1003
Query: 679 LADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHR-------NEICNPE---------- 721
L DR +++ GRL C GS +FL+R G GY+L+L + NE + +
Sbjct: 1004 LGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQE 1063
Query: 722 -------------QITSFITHHIPDAKLKTENKEKLVYTLPLERTN--TFPDLFSDLD-K 765
Q+ + + H +P A+L E +LV LP + +F LF +LD +
Sbjct: 1064 KKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTR 1123
Query: 766 CSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFE-------------------QVEMIRD 806
++ +TGY IS ++L E+F+K+ + + D E +++M
Sbjct: 1124 LAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQ 1183
Query: 807 SESLNEMELAHSSFSEMQTA-------VSDMGLWRMQVFAMARLRFLKLKRQ-----TKV 854
+L E A S+ Q + V L R Q+ A+ RFL +R ++
Sbjct: 1184 ETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQI 1243
Query: 855 LLTLLLVFGIAIFPLIV 871
+L L V +F LIV
Sbjct: 1244 VLPALFVGLALVFSLIV 1260
Score = 210 bits (534), Expect = 1e-53
Identities = 192/687 (27%), Positives = 300/687 (43%), Gaps = 102/687 (14%)
Query: 967 NTKRLHCFPILMNIISNGLLQMF------NHTQHIRIESSPFPLSHIGLWTG-LPDGSFF 1019
N K H +N SN +L+ H I + P L+ L G L S
Sbjct: 1476 NNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVD 1535
Query: 1020 LFLVLCSISPY------ITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILIL 1073
+ + +C + T+ I + AK + GL + YW G L D+ +++
Sbjct: 1536 VLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPA 1595
Query: 1074 LLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFY 1133
++ LIF + Q + + AL+++ Y S+ +Y SF +
Sbjct: 1596 CIVVLIF-LAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASF--------------F 1640
Query: 1134 FFFASTIMFSITLINHF---------------------DLSILITTMVLVPSYTLLGFKT 1172
F ST +T IN F ++S ++ + L+ + LG
Sbjct: 1641 FSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGL 1700
Query: 1173 FLEVRDQEHYREFPEAN---------FELSATDFLVCFIPYFQTLLFVFVLRCMELKCGK 1223
VR+Q F +E+ + L I LLF +L+ +
Sbjct: 1701 IDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQ 1760
Query: 1224 KRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLH 1283
R+R P+ +EDED+ ER R T + V++ L
Sbjct: 1761 PRVRSLPLLG----------------EEDEDVARERERVVQGAT-----QGDVLVLRNLT 1799
Query: 1284 KEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGE 1343
K Y GQ+ A + + GE GLLG NGAGK+S+ RM++G T + GE
Sbjct: 1800 KVYRGQRMP---------AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGE 1850
Query: 1344 VELKGCSSV----LGHL--GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLV 1397
L G S HL GYCPQ + ++ +LT REHLE+ A ++G+ +A +
Sbjct: 1851 AVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGL 1910
Query: 1398 SAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
+ L + P + G RKL L+L+G+ V+ LDEP+TG+DP+ ++ +W ++ A
Sbjct: 1911 ARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLA 1970
Query: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV--- 1514
VV+ R V+LT+H++ E EALC R+AIMV+GR RC+GS QHLK + + L L+V
Sbjct: 1971 VVRE-GRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAA 2029
Query: 1515 KETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEE 1574
+ V E FP A +E + L ++LP L++ F +L +E+
Sbjct: 2030 RSQPAAAFVAAE----FPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
Query: 1575 YSLSQCTLEKVFLELSKEQEVGNFDEE 1601
+S+SQ LE+VFL SK+Q EE
Sbjct: 2086 FSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
Score = 171 bits (434), Expect = 4e-42
Identities = 158/636 (24%), Positives = 280/636 (44%), Gaps = 60/636 (9%)
Query: 190 TTNHPV--MEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERK 247
T NHP+ +E +S A+ ++ + + F + F P + + L + +
Sbjct: 1512 TLNHPLNLTKEQLSEGALMASSVDVLVS-------ICVVFAMSFVPASFTLVL-IEERVT 1563
Query: 248 KSKNLMKMMGLQDSAFWLS---WGLIYAGFIFIISIFVTIIITFTQ--IIVMTGFMVIFI 302
++K+L M GL + +WL W + ++ I V I + F Q + + +
Sbjct: 1564 RAKHLQLMGGLSPTLYWLGNFLWDM--CNYLVPACIVVLIFLAFQQRAYVAPANLPALLL 1621
Query: 303 LFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY----------EQLP 352
L LYG S+ L++ S +V+ + LF G G + +++
Sbjct: 1622 LLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVS 1681
Query: 353 SSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLL 412
L+ + I F G+I +++ + + GD S L + + L
Sbjct: 1682 RILKQVFLIFPHFCLGRGLIDMVRNQAMADAF---ERLGDRQFQ----SPLRWEVVGKNL 1734
Query: 413 LALYFDKILPYGDERHYSPLFFL------NSSSCFQHQRTNAKVIEKEIDAEHPSDDYFE 466
LA+ PLF L + S R + + E D E + +
Sbjct: 1735 LAMVIQ-----------GPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEED-EDVARERER 1782
Query: 467 PVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNI 526
V QG + + +RN+ K Y+G+ ++ A+ L I G+ +LG +GAGK+S +
Sbjct: 1783 VVQGATQG-DVLVLRNLTKVYRGQ--RMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRM 1839
Query: 527 LNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGI 586
+ G ++ + G + +++ + G CPQ + F++LT +E+L L A+++G+
Sbjct: 1840 VTGDTLASRGEAVLAGHSVAREPSAAHLSM--GYCPQSDAIFELLTGREHLELLARLRGV 1897
Query: 587 HLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLD 646
+V Q L L + D A S G KRKL + ++GDP ++ LDEPTTG+D
Sbjct: 1898 PEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMD 1957
Query: 647 PFSRDQVW-SLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWG 705
P +R +W SLL R ++ ++ SM+E + L R IM NGR +C GS LK R+
Sbjct: 1958 PSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFA 2017
Query: 706 LGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLD- 764
G+ L+L R + +F+ P A+L+ + +L + LP +F +L
Sbjct: 2018 AGHTLTL-RVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAV 2076
Query: 765 KCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQ 800
++ GV + +S + L EVF+ ++D E+
Sbjct: 2077 HGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEE 2112
Score = 148 bits (373), Expect = 5e-35
Identities = 113/363 (31%), Positives = 177/363 (48%), Gaps = 55/363 (15%)
Query: 1302 AARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGH 1355
A R +S +G I LG NGAGK++++ ++SG+ P+ G + G +++ H
Sbjct: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882
Query: 1356 LGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTA 1415
LG CPQ NVL+ MLT+ EH+ Y +KGL A RL+ L + +V + L+
Sbjct: 883 LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942
Query: 1416 GITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTE-RGVLLTTHNLA 1474
G+ RKL ++ +G S V++LDEP+ G+DP ++ +W+ + +K E R ++L+TH+L
Sbjct: 943 GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL---LKYREGRTLILSTHHLD 999
Query: 1475 EAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL---------------------- 1512
EAE L DRVA++ GRL C GS L+ LG Y L L
Sbjct: 1000 EAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVD 1059
Query: 1513 ---KVKETSQVTLVHT-EILKL----FPQAAGQERYSSLLTYKLPVADVY--PLSQTFHK 1562
+ K SQ + V T ++L L P A E L LP + + F +
Sbjct: 1060 TRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRE 1119
Query: 1563 LEAVKHNFNLEEYSLSQCTLEKVFLELSKE------QEVGNFDEE-------IDTTMRWK 1609
L+ L Y +S +LE++FL++ +E E G+ + +D T+R K
Sbjct: 1120 LDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLK 1179
Query: 1610 LLP 1612
+ P
Sbjct: 1180 MPP 1182
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 107 bits (267), Expect = 9e-23
Identities = 52/164 (31%), Positives = 96/164 (58%), Gaps = 1/164 (0%)
Query: 1369 LTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLL 1428
+T +E + +YA + G+ + L + + +++ +L + + G R+L ++L+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1429 GNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVS 1488
G S V+ LDEPSTG+DP ++ +W + + + + +++T+H++ E +ALC +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1489 GRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFP 1532
G+ C+GS QHLK+K G YIL++KVK ++ + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 88.6 bits (218), Expect = 4e-17
Identities = 45/143 (31%), Positives = 82/143 (57%), Gaps = 1/143 (0%)
Query: 571 LTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITIL 630
+T +E + ++A+I G+ ++ V + L L++++ L SEG KR+L+ I ++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFSTQSMDEADILADRKVIMSNG 689
G ++ LDEP+TG+DP +R +W+++ + R + I+ ++ SM+E D L IM G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 RLKCAGSSMFLKRRWGLGYHLSL 712
+ C GS LK ++G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 107 bits (267), Expect = 9e-23
Identities = 52/164 (31%), Positives = 96/164 (58%), Gaps = 1/164 (0%)
Query: 1369 LTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLL 1428
+T +E + +YA + G+ + L + + +++ +L + + G R+L ++L+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1429 GNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVS 1488
G S V+ LDEPSTG+DP ++ +W + + + + +++T+H++ E +ALC +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1489 GRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFP 1532
G+ C+GS QHLK+K G YIL++KVK ++ + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 88.6 bits (218), Expect = 4e-17
Identities = 45/143 (31%), Positives = 82/143 (57%), Gaps = 1/143 (0%)
Query: 571 LTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITIL 630
+T +E + ++A+I G+ ++ V + L L++++ L SEG KR+L+ I ++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFSTQSMDEADILADRKVIMSNG 689
G ++ LDEP+TG+DP +R +W+++ + R + I+ ++ SM+E D L IM G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 RLKCAGSSMFLKRRWGLGYHLSL 712
+ C GS LK ++G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 107 bits (267), Expect = 9e-23
Identities = 52/164 (31%), Positives = 96/164 (58%), Gaps = 1/164 (0%)
Query: 1369 LTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLL 1428
+T +E + +YA + G+ + L + + +++ +L + + G R+L ++L+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1429 GNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVS 1488
G S V+ LDEPSTG+DP ++ +W + + + + +++T+H++ E +ALC +AIMV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1489 GRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFP 1532
G+ C+GS QHLK+K G YIL++KVK ++ + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 88.6 bits (218), Expect = 4e-17
Identities = 45/143 (31%), Positives = 82/143 (57%), Gaps = 1/143 (0%)
Query: 571 LTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITIL 630
+T +E + ++A+I G+ ++ V + L L++++ L SEG KR+L+ I ++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFSTQSMDEADILADRKVIMSNG 689
G ++ LDEP+TG+DP +R +W+++ + R + I+ ++ SM+E D L IM G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 RLKCAGSSMFLKRRWGLGYHLSL 712
+ C GS LK ++G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 87.8 bits (216), Expect = 8e-17
Identities = 78/265 (29%), Positives = 127/265 (47%), Gaps = 17/265 (6%)
Query: 437 SSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEA 496
S F + R A I K ID + D Y + K + RNV Y + +V+
Sbjct: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRK-EVKI 409
Query: 497 LKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRK 556
LKGL + GQ A++G+SG GKS+ + ++ L PTEG V++ +++ + ++ +R+
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTI-NVRFLRE 468
Query: 557 ITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-------ILLELDMQNIQD 609
I GV Q V F T+ EN+ + + + E+E+ V+ + L +
Sbjct: 469 IIGVVSQEPVLF-ATTIAENIRYGR--ENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVG 525
Query: 610 NLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRADHVI 666
LS GQK+++ ++ +P+ILLLDE T+ LD S V L R+ R VI
Sbjct: 526 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585
Query: 667 LFSTQSMDEADILA--DRKVIMSNG 689
++ AD++A D VI+ G
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKG 610
Score = 79.0 bits (193), Expect = 4e-14
Identities = 58/227 (25%), Positives = 112/227 (49%), Gaps = 16/227 (7%)
Query: 494 VEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEE 553
+ L+GL ++ +GQ A++G SG GKS+++ +L P G V + K + + +++
Sbjct: 1050 IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRL-NVQW 1108
Query: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLA- 612
+R G+ Q + FD ++ EN++ + + +E+ + + + ++++ + +
Sbjct: 1109 LRAHLGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167
Query: 613 ------KHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRAD 663
LS GQK+++ ++ P ILLLDE T+ LD S V L RE R
Sbjct: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227
Query: 664 HVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
VI ++ AD++ V+ NGR+K G+ L + G+ + +
Sbjct: 1228 IVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 53.5 bits (127), Expect = 2e-06
Identities = 48/217 (22%), Positives = 103/217 (47%), Gaps = 20/217 (9%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG-------CSSVLGHL 1356
+ +S V++G+ L L+G +G GKS+ ++++ P AG+V L G + HL
Sbjct: 1054 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL 1113
Query: 1357 GYCPQENVLWPM-----LTLREHLEVYA---AVKGLRKADARLAIARLVSAFKLHEQLNV 1408
G QE +L+ + ++ V + V+ ++A+ I L + K ++
Sbjct: 1114 GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPN--KYSTKVGD 1171
Query: 1409 PVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLL 1468
+L+ G +++ +L+ +LLLDE ++ +D ++ + +A+ + R ++
Sbjct: 1172 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREG--RTCIV 1229
Query: 1469 TTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ + D + + +GR++ G+ Q L + G
Sbjct: 1230 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1265
Score = 51.6 bits (122), Expect = 6e-06
Identities = 44/194 (22%), Positives = 90/194 (46%), Gaps = 17/194 (8%)
Query: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG----- 1348
+ RK+ + ++ VQ G+ + L+G +G GKS++++++ + PT G V + G
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 1349 --CSSVLGHLGYCPQENVLWPMLTL------REHLEVYAAVKGLRKADARLAIARLVSAF 1400
+ +G QE VL+ RE++ + K +++A+A I +L
Sbjct: 461 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKL--PH 518
Query: 1401 KLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVK 1460
K + +L+ G +++ +L+ N +LLLDE ++ +D + + A+ K
Sbjct: 519 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARK 578
Query: 1461 NTERGVLLTTHNLA 1474
R ++ H L+
Sbjct: 579 G--RTTIVIAHRLS 590
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 87.8 bits (216), Expect = 8e-17
Identities = 79/300 (26%), Positives = 144/300 (48%), Gaps = 26/300 (8%)
Query: 497 LKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTE---GSVTIYNKNLSEMQDLEE 553
++ L F + GQ+ AI+G SG G++SLL+++ G + G + I + S +
Sbjct: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP----QL 143
Query: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIK---GIHLKEVEQEVQRILLELDMQNIQDN 610
+RK Q N LTV+E L+ A+++ + ++ V+ ++ EL ++ D
Sbjct: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
Query: 611 -----LAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPF-SRDQVWSLLRERRADH 664
+ LS G++R+++ G+ +L +P IL+LDEPT+GLD F + + V +L R + +
Sbjct: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
Query: 665 VILFST-QSMDEADILADRKVIMSNGRLKCAGSSMFLKRRW-GLGYHLSLHRNEICNPEQ 722
++L S Q + L D ++M++G G++ + + + +GY + N
Sbjct: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVD 323
Query: 723 ITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLF-------SDLDKCSDQGVTGYD 775
+TS I + +L T K + + L LE+ D D D C + VT D
Sbjct: 324 LTS-IDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLD 382
Score = 73.6 bits (179), Expect = 1e-12
Identities = 59/217 (27%), Positives = 113/217 (52%), Gaps = 17/217 (7%)
Query: 1300 KIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGIT---KPTAGEVELKGCSS----V 1352
++ +N+SF V+ G++L ++G +G G++S + +I+G K +G++ + G S V
Sbjct: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
Query: 1353 LGHLGYCPQENVLWPMLTLREHLEVYAAVKGLR---KADARLAIARLVSAFKLHEQL--- 1406
+ + Q N L P LT+RE L A ++ R +A + +++ +L +
Sbjct: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
Query: 1407 --NVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTER 1464
N+ V+ L+ G R++ + LL N +L+LDEP++G+D + + + + K R
Sbjct: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKG-NR 263
Query: 1465 GVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
VL++ H ++ L D V +M SG +G+ QH+
Sbjct: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM 300
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 146
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 147 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 206
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 207 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 266
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 267 ICTIHQPSAKLFELFDQLYVLSQGQ 291
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 150
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 151 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 210
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 211 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 269
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 270 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 301
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 127
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 128 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 187
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 188 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 247
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 248 ICTIHQPSAKLFELFDQLYVLSQGQ 272
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 131
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 132 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 191
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 192 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 250
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 251 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 282
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 151
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 152 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 211
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 212 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 271
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 272 ICTIHQPSAKLFELFDQLYVLSQGQ 296
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 155
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 156 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 215
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 216 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 274
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 275 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 306
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 160
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 161 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 220
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 221 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 280
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 281 ICTIHQPSAKLFELFDQLYVLSQGQ 305
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 164
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 165 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 224
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 225 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 283
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 284 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 315
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 149
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 150 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 209
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 210 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 269
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 270 ICTIHQPSAKLFELFDQLYVLSQGQ 294
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 153
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 154 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 213
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 214 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 272
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 304
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 82.0 bits (201), Expect = 4e-15
Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)
Query: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548
K G LKG+ G++ AI+G SGAGKS+L+NIL G +G+V I
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 149
Query: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607
+DL RK++ Q ++ LTV+E + + A +K E +E V+ IL L + +
Sbjct: 150 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 209
Query: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667
+ LS GQ+++L + ++ +P ++ DEPT+GLD S QV SL++ +
Sbjct: 210 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 269
Query: 668 FSTQSMDEADI--LADRKVIMSNGR 690
T A + L D+ ++S G+
Sbjct: 270 ICTIHQPSAKLFELFDQLYVLSQGQ 294
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)
Query: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354
K+ K + IS GE++ ++GP+GAGKS+ + +++G + G V + G L
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 153
Query: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409
Y Q+++L P LT++E + V A +K K + R + + +++A L N
Sbjct: 154 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 213
Query: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469
L+ G ++L L L+ N PV+ DEP++G+D Q+ ++ + + R ++ T
Sbjct: 214 TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 272
Query: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
H A+ L D++ ++ G+ G + +L
Sbjct: 273 IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 304
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 82.0 bits (201), Expect = 4e-15
Identities = 77/278 (27%), Positives = 128/278 (46%), Gaps = 15/278 (5%)
Query: 441 FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGL 500
F + R A VI ID D + E K + +V Y ++ V+ LKGL
Sbjct: 357 FANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRAN-VKILKGL 415
Query: 501 LFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGV 560
+ GQ A++G SG GKS+ + ++ L P EG++ I +++ ++ +R+I GV
Sbjct: 416 NLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF-NVNYLREIIGV 474
Query: 561 CPQFNVQFDILTVKENLSL-FAKIKGIHLKEVEQEVQRILLELDMQNIQDNL----AKHL 615
Q V F T+ EN+ + +K+ +E + + D L L
Sbjct: 475 VSQEPVLFS-TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
Query: 616 SEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRADHVILFSTQS 672
S GQK+++ ++ +P+ILLLDE T+ LD S +V + L RE R VI +
Sbjct: 534 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLST 593
Query: 673 MDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
+ AD++A +G + GS L ++ G+ + L
Sbjct: 594 VRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 72.8 bits (177), Expect = 3e-12
Identities = 61/233 (26%), Positives = 111/233 (47%), Gaps = 21/233 (9%)
Query: 494 VEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTI-YNKNLSEMQDLE 552
V L+GL ++ +GQ A++G SG GKS+++ +L P G+V + + L + Q+ +
Sbjct: 1049 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAK 1108
Query: 553 E-----IRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNI 607
+ +R G+ Q + FD ++ EN++ + + E+ + + ++ +
Sbjct: 1109 KLNVQWLRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
Query: 608 Q-------DNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL--- 657
+ LS GQK+++ ++ PQILLLDE T+ LD S V L
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA 1227
Query: 658 RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
RE R VI ++ AD++ V+ NGR+K G+ L + G+ + +
Sbjct: 1228 REGRTCIVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 48.5 bits (114), Expect = 5e-05
Identities = 47/215 (21%), Positives = 96/215 (44%), Gaps = 18/215 (8%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG-------CSSVLGHL 1356
+ ++ VQ G+ + L+G +G GKS+++++I + P G + + G + + +
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 1357 GYCPQENVLWPMLTL------REHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPV 1410
G QE VL+ R ++ + K +++A+A I +L K +
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQ--KFDTLVGERG 530
Query: 1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTT 1470
+L+ G +++ +L+ N +LLLDE ++ +D + ++ A+ + R ++
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG--RTTIVIA 588
Query: 1471 HNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ D +A G + GS L K G
Sbjct: 589 HRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKEG 622
Score = 45.1 bits (105), Expect = 6e-04
Identities = 46/224 (20%), Positives = 100/224 (44%), Gaps = 27/224 (12%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVL---------- 1353
+ +S V++G+ L L+G +G GKS+ ++++ P AG V + +L
Sbjct: 1053 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNV 1112
Query: 1354 ----GHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVP 1409
LG QE +L+ ++ E++ Y + D ++ A+ + E L
Sbjct: 1113 QWLRAQLGIVSQEPILFDC-SIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1170
Query: 1410 VQ--------KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKN 1461
+ +L+ G +++ +L+ +LLLDE ++ +D ++ + +A+ +
Sbjct: 1171 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG 1230
Query: 1462 TERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
R ++ H L+ + D + + +GR++ G+ Q L + G
Sbjct: 1231 --RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1271
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 82.0 bits (201), Expect = 4e-15
Identities = 77/278 (27%), Positives = 128/278 (46%), Gaps = 15/278 (5%)
Query: 441 FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGL 500
F + R A VI ID D + E K + +V Y ++ V+ LKGL
Sbjct: 357 FANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRAN-VKILKGL 415
Query: 501 LFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGV 560
+ GQ A++G SG GKS+ + ++ L P EG++ I +++ ++ +R+I GV
Sbjct: 416 NLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF-NVNYLREIIGV 474
Query: 561 CPQFNVQFDILTVKENLSL-FAKIKGIHLKEVEQEVQRILLELDMQNIQDNL----AKHL 615
Q V F T+ EN+ + +K+ +E + + D L L
Sbjct: 475 VSQEPVLFS-TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
Query: 616 SEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRADHVILFSTQS 672
S GQK+++ ++ +P+ILLLDE T+ LD S +V + L RE R VI +
Sbjct: 534 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLST 593
Query: 673 MDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
+ AD++A +G + GS L ++ G+ + L
Sbjct: 594 VRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 80.1 bits (196), Expect = 2e-14
Identities = 79/319 (24%), Positives = 148/319 (46%), Gaps = 35/319 (10%)
Query: 414 ALYFDKILPYGDERHYSPLFF----LNSSSCFQHQRTNAKV--------IEKEIDAEHPS 461
++Y +K+ YG R +S + F L +S F AK+ E++ + S
Sbjct: 917 SMYVEKL--YGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYS 974
Query: 462 DDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKS 521
++ +P +F+G I V Y ++ V L+GL ++ +GQ A++G SG GKS
Sbjct: 975 EEGLKP--DKFEGN--ITFNEVVFNYPTRAN-VPVLQGLSLEVKKGQTLALVGSSGCGKS 1029
Query: 522 SLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFA 581
+++ +L P G+V + + ++ +++ +R G+ Q + FD ++ EN++
Sbjct: 1030 TVVQLLERFYDPLAGTVLLDGQEAKKL-NVQWLRAQLGIVSQEPILFD-CSIAENIAYGD 1087
Query: 582 KIKGIHLKEVEQEVQRILLELDMQNIQ-------DNLAKHLSEGQKRKLTFGITILGDPQ 634
+ + E+ + + ++ + + LS GQK+++ ++ PQ
Sbjct: 1088 NSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQ 1147
Query: 635 ILLLDEPTTGLDPFSRDQVWSLL---RERRADHVILFSTQSMDEADILADRKVIMSNGRL 691
ILLLDE T+ LD S V L RE R VI ++ AD++ V+ NGR+
Sbjct: 1148 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLI----VVFQNGRV 1203
Query: 692 KCAGSSMFLKRRWGLGYHL 710
K G+ L + G+ + +
Sbjct: 1204 KEHGTHQQLLAQKGIYFSM 1222
Score = 51.2 bits (121), Expect = 8e-06
Identities = 47/217 (21%), Positives = 101/217 (46%), Gaps = 20/217 (9%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
+ +S V++G+ L L+G +G GKS+ ++++ P AG V L G + + L
Sbjct: 1006 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQL 1065
Query: 1357 GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQ----- 1411
G QE +L+ ++ E++ Y + D ++ A+ + E L +
Sbjct: 1066 GIVSQEPILFD-CSIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1123
Query: 1412 ---KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLL 1468
+L+ G +++ +L+ +LLLDE ++ +D ++ + +A+ + R ++
Sbjct: 1124 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG--RTCIV 1181
Query: 1469 TTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ + D + + +GR++ G+ Q L + G
Sbjct: 1182 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1217
Score = 48.5 bits (114), Expect = 5e-05
Identities = 47/215 (21%), Positives = 96/215 (44%), Gaps = 18/215 (8%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG-------CSSVLGHL 1356
+ ++ VQ G+ + L+G +G GKS+++++I + P G + + G + + +
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 1357 GYCPQENVLWPMLTL------REHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPV 1410
G QE VL+ R ++ + K +++A+A I +L K +
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQ--KFDTLVGERG 530
Query: 1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTT 1470
+L+ G +++ +L+ N +LLLDE ++ +D + ++ A+ + R ++
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG--RTTIVIA 588
Query: 1471 HNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ D +A G + GS L K G
Sbjct: 589 HRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKEG 622
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 82.0 bits (201), Expect = 4e-15
Identities = 77/278 (27%), Positives = 128/278 (46%), Gaps = 15/278 (5%)
Query: 441 FQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGL 500
F + R A VI ID D + E K + +V Y ++ V+ LKGL
Sbjct: 357 FANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRAN-VKILKGL 415
Query: 501 LFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGV 560
+ GQ A++G SG GKS+ + ++ L P EG++ I +++ ++ +R+I GV
Sbjct: 416 NLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF-NVNYLREIIGV 474
Query: 561 CPQFNVQFDILTVKENLSL-FAKIKGIHLKEVEQEVQRILLELDMQNIQDNL----AKHL 615
Q V F T+ EN+ + +K+ +E + + D L L
Sbjct: 475 VSQEPVLFS-TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQL 533
Query: 616 SEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRADHVILFSTQS 672
S GQK+++ ++ +P+ILLLDE T+ LD S +V + L RE R VI +
Sbjct: 534 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLST 593
Query: 673 MDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
+ AD++A +G + GS L ++ G+ + L
Sbjct: 594 VRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 75.9 bits (185), Expect = 3e-13
Identities = 59/227 (25%), Positives = 110/227 (48%), Gaps = 16/227 (7%)
Query: 494 VEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEE 553
V L+GL ++ +GQ A++G SG GKS+++ +L P G+V + + ++ +++
Sbjct: 1049 VPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKL-NVQW 1107
Query: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQ----- 608
+R G+ Q + FD ++ EN++ + + E+ + + ++ +
Sbjct: 1108 LRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1166
Query: 609 --DNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL---RERRAD 663
+ LS GQK+++ ++ PQILLLDE T+ LD S V L RE R
Sbjct: 1167 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1226
Query: 664 HVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHL 710
VI ++ AD++ V+ NGR+K G+ L + G+ + +
Sbjct: 1227 IVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 51.2 bits (121), Expect = 8e-06
Identities = 47/217 (21%), Positives = 101/217 (46%), Gaps = 20/217 (9%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
+ +S V++G+ L L+G +G GKS+ ++++ P AG V L G + + L
Sbjct: 1053 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQL 1112
Query: 1357 GYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQ----- 1411
G QE +L+ ++ E++ Y + D ++ A+ + E L +
Sbjct: 1113 GIVSQEPILFD-CSIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1170
Query: 1412 ---KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLL 1468
+L+ G +++ +L+ +LLLDE ++ +D ++ + +A+ + R ++
Sbjct: 1171 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREG--RTCIV 1228
Query: 1469 TTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ + D + + +GR++ G+ Q L + G
Sbjct: 1229 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1264
Score = 48.5 bits (114), Expect = 5e-05
Identities = 47/215 (21%), Positives = 96/215 (44%), Gaps = 18/215 (8%)
Query: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG-------CSSVLGHL 1356
+ ++ VQ G+ + L+G +G GKS+++++I + P G + + G + + +
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 1357 GYCPQENVLWPMLTL------REHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPV 1410
G QE VL+ R ++ + K +++A+A I +L K +
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQ--KFDTLVGERG 530
Query: 1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTT 1470
+L+ G +++ +L+ N +LLLDE ++ +D + ++ A+ + R ++
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG--RTTIVIA 588
Query: 1471 HNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLG 1505
H L+ D +A G + GS L K G
Sbjct: 589 HRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKEG 622
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 80.1 bits (196), Expect = 2e-14
Identities = 64/214 (29%), Positives = 109/214 (50%), Gaps = 16/214 (7%)
Query: 495 EALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL---SVPTEGSVTIYNKNLSEMQDL 551
+ LK + + GQI ILG SG+GK++LL+ ++G + G V + + L
Sbjct: 67 QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---- 122
Query: 552 EEIRKITGVCPQFNVQFDILTVKENLSLFA--KIKGIHLKEVEQEVQRILLELDMQNIQD 609
E+ + Q + LTV+E L A I+ + +++V+ ++ EL + ++ D
Sbjct: 123 EQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVAD 182
Query: 610 NLAKH-----LSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRE--RRA 662
L + +S G++R+++ +L DP+++L DEPTTGLD + +Q+ LL E RR
Sbjct: 183 RLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRN 242
Query: 663 DHVILFSTQSMDEADILADRKVIMSNGRLKCAGS 696
V+L Q E L D+ I+S G L G+
Sbjct: 243 RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Score = 58.9 bits (141), Expect = 4e-08
Identities = 61/222 (27%), Positives = 109/222 (49%), Gaps = 21/222 (9%)
Query: 1292 SCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA---GEVELKG 1348
SC + ++I +++S V+ G+I+ +LG +G+GK++ + +SG GEV + G
Sbjct: 59 SCRQQWTRQIL-KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNG 117
Query: 1349 CS----SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARL------AIARLVS 1398
+ Y Q + L LT+RE L Y A+ +R+ + A+ +S
Sbjct: 118 RALRREQFQDCFSYVLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELS 176
Query: 1399 AFKLHEQL--NVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGID-PTGQQQMWQAI 1455
+ ++L N + ++ G R++ LL + V+L DEP+TG+D T Q + +
Sbjct: 177 LSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLV 236
Query: 1456 QAVVKNTERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGS 1496
+ +N R V+LT H +E L D++AI+ G L G+
Sbjct: 237 ELARRN--RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,081,345
Number of Sequences: 37866
Number of extensions: 2431574
Number of successful extensions: 7166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 6428
Number of HSP's gapped (non-prelim): 370
length of query: 1617
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1501
effective length of database: 13,855,062
effective search space: 20796448062
effective search space used: 20796448062
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.