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Search of human proteins with 26190616
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26190616 kelch domain containing 1 [Homo sapiens]
(406 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26190616 kelch domain containing 1 [Homo sapiens] 880 0.0
gi|7657301 kelch domain containing 2 [Homo sapiens] 348 6e-96
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 86 6e-17
gi|7019405 host cell factor C2 [Homo sapiens] 83 5e-16
gi|98986457 host cell factor 1 [Homo sapiens] 79 6e-15
gi|62955044 F-box protein 42 [Homo sapiens] 77 3e-14
gi|16945972 kelch domain containing 3 [Homo sapiens] 74 2e-13
gi|44917619 kelch domain containing 10 [Homo sapiens] 69 1e-11
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 61 2e-09
gi|21314675 kelch domain containing 4 [Homo sapiens] 57 3e-08
gi|46410931 attractin-like 1 [Homo sapiens] 48 2e-05
gi|11056006 kelch-like 12 [Homo sapiens] 45 2e-04
gi|55741643 kelch-like 14 [Homo sapiens] 45 2e-04
gi|31881798 muskelin 1, intracellular mediator containing kelch ... 42 8e-04
gi|223890246 muskelin 1, intracellular mediator containing kelch... 42 8e-04
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 42 0.001
gi|8922640 kelch domain containing 8A [Homo sapiens] 41 0.002
gi|24308181 kelch-like 9 [Homo sapiens] 39 0.011
gi|158508542 kelch-like 33 [Homo sapiens] 38 0.019
gi|55925604 kelch-like 18 [Homo sapiens] 38 0.019
gi|24432026 kelch-like [Homo sapiens] 38 0.019
gi|148664248 kelch domain containing 6 [Homo sapiens] 38 0.019
gi|27734909 kelch domain containing 8B [Homo sapiens] 38 0.019
gi|45643138 kelch-like 13 [Homo sapiens] 37 0.025
gi|14780904 kelch-like 1 protein [Homo sapiens] 37 0.025
gi|40255071 kelch-like 23 [Homo sapiens] 37 0.025
gi|21450863 attractin isoform 2 [Homo sapiens] 37 0.042
gi|21450861 attractin isoform 1 [Homo sapiens] 37 0.042
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 37 0.042
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 37 0.042
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 880 bits (2274), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 1 MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHL 60
MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHL
Sbjct: 1 MADSQLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHL 60
Query: 61 MEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQP 120
MEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQP
Sbjct: 61 MEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQP 120
Query: 121 PTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKT 180
PTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKT
Sbjct: 121 PTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKT 180
Query: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI 240
QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI
Sbjct: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI 240
Query: 241 NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL 300
NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL
Sbjct: 241 NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL 300
Query: 301 WHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLES 360
WHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLES
Sbjct: 301 WHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLES 360
Query: 361 QISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN 406
QISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN
Sbjct: 361 QISLLPPKLLQQVLKKITFWAAANHREEQRVQKEETENKYQWISSN 406
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 348 bits (892), Expect = 6e-96
Identities = 173/374 (46%), Positives = 235/374 (62%), Gaps = 9/374 (2%)
Query: 5 QLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDN---EVYLPNDEIWTYDIDSGLWRMHLM 61
+L C AE RSGH AV DG ++VWGGY S + + YLP +E+W Y++++G W+
Sbjct: 25 ELACPAE-RSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINT 83
Query: 62 EGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPP 121
EG++P SMSGSC C++ LY+FGG+ +G +N+ Y ++ R+ D WE+I D +G PP
Sbjct: 84 EGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERI-DCQGIPP 142
Query: 122 TPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDAS-WEEQIFWGWHNDVHIFDTKT 180
+ +DKL WVYK++LI+FGGYG ++ F+ + S W GW++ VHI DT+T
Sbjct: 143 SSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTET 202
Query: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI 240
TW QP I G P PRAAH CA +GN+G++FGGR RMNDLHYLNLDTW W+ I
Sbjct: 203 FTWSQP-ITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIP- 260
Query: 241 NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL 300
G P RSWH+LTP++ D LFL GG + D PLSD W + ++ N W Q H +PRL
Sbjct: 261 QGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRL 320
Query: 301 WHTACLGKENEIMVFGGSKDDLLALD-TGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLE 359
WHTAC E E++VFGG ++LL H N++LIF QP SL+R L+ + ML
Sbjct: 321 WHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLA 380
Query: 360 SQISLLPPKLLQQV 373
+ + LP LL V
Sbjct: 381 NSWNCLPKHLLHSV 394
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 85.9 bits (211), Expect = 6e-17
Identities = 61/224 (27%), Positives = 97/224 (43%), Gaps = 22/224 (9%)
Query: 13 RSGHCAVVDGNFLYVWGGYVS-IEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSG 71
R H AVV G+ ++V+GGY I N ++++ Y +G W +EG LP + S
Sbjct: 118 RYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSA 177
Query: 72 SCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWV 131
+ KL+IF GYD N ++ + L+ R+ T WE++ G+ P V
Sbjct: 178 HGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELT-CWEEVAQ-SGEIPPSCCNFPVAV 235
Query: 132 YKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGG 191
+D++ F G + + F+ D +W T+ + ++G
Sbjct: 236 CRDKMFVFSGQSGAKITNNLFQFEFKDKTW------------------TRIPTEHLLRGS 277
Query: 192 -VPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTW 234
PPQ R HT Y+FGG T N+LH ++D TW
Sbjct: 278 PPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTW 321
Score = 56.2 bits (134), Expect = 5e-08
Identities = 72/268 (26%), Positives = 113/268 (42%), Gaps = 37/268 (13%)
Query: 81 LYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFG 140
+Y+FGG + K N L LR + W + G PP PR S VY + FG
Sbjct: 80 IYVFGGDNGKTMLNDL----LRFDVKDCSWCRAFT-TGTPPAPRYHHSAVVYGSSMFVFG 134
Query: 141 GYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAH 200
GY D++ S + ND+ + T W + +I+G + P R+AH
Sbjct: 135 GY----------TGDIYSNSNLKN-----KNDLFEYKFATGQWTEWKIEGRL-PVARSAH 178
Query: 201 TCAVLGNKGYIFGGRVLQTRMNDLHYLNL---DTWTWSGRITINGESPKHRSWHTLTPIA 257
V +K +IF G R+ND+ + L + W + +GE P + +
Sbjct: 179 GATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWE-EVAQSGEIPP-SCCNFPVAVC 236
Query: 258 DDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQL--THL-----PKTRPRLWHTACLGKEN 310
DK+F+ G S I ++ + W ++ HL P + R HT + +
Sbjct: 237 RDKMFVFSGQSGAKI-TNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHT-MVAFDR 294
Query: 311 EIMVFGGSKDDLLALDTGHCNDLLIFQT 338
+ VFGG+ D+ L + HC D + FQT
Sbjct: 295 HLYVFGGAADNTLPNEL-HCYD-VDFQT 320
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/229 (24%), Positives = 83/229 (36%), Gaps = 36/229 (15%)
Query: 99 VNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHD 158
+N + + W ++ + R K + YKD + FGG + FDV D
Sbjct: 43 LNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKD 102
Query: 159 ASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQ 218
SW F T G PP PR H+ V G+ ++FGG
Sbjct: 103 CSW-----------CRAFTT------------GTPPAPRYHHSAVVYGSSMFVFGGYTGD 139
Query: 219 -------TRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADN 271
NDL T W+ I G P RS H T + DKL++ G N
Sbjct: 140 IYSNSNLKNKNDLFEYKFATGQWT-EWKIEGRLPVARSAHGAT-VYSDKLWIFAGYDG-N 196
Query: 272 IPLSDGW---IHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
L+D W + + CW+++ + P + +++ VF G
Sbjct: 197 ARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSG 245
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 82.8 bits (203), Expect = 5e-16
Identities = 90/360 (25%), Positives = 139/360 (38%), Gaps = 91/360 (25%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
V R GH AV + ++GG NE DE+ Y+ + W + + G++P
Sbjct: 19 VPRARHGHRAVAIRELMIIFGG-----GNEGIA--DELHVYNTATNQWFLPAVRGDIPPG 71
Query: 69 MSGSCGACINGKLYIFGGYDDKG-YSNRLYFVNLRTRDETYIWEKITDF---EGQPPTPR 124
+ C ++ +FGG + G YSN LY + ++W+K+ G PP PR
Sbjct: 72 CAAHGFVCDGTRILVFGGMVEYGRYSNELY----ELQASRWLWKKVKPHPPPSGLPPCPR 127
Query: 125 DKLSCWVYKDRLIYFGGYGCRRHSE-------LQDCFDVH-------------------- 157
S +Y ++ FGG L D +++
Sbjct: 128 LGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGVVP 187
Query: 158 ---------------DASWEEQIFWGW----HNDVHIFDTKTQTWFQPEIKGGVPPQPRA 198
S + +F G +D+ D +T +W +PE KG V P PR+
Sbjct: 188 SPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTV-PLPRS 246
Query: 199 AHTCAVLGNKGYIFGGRV------LQTRMND--------LHYLNLDTWTWSGRITINGES 244
HT +V+GNK YIFGG V +T +D YLNLDT W+ ++ + E
Sbjct: 247 LHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDSQED 306
Query: 245 -----PKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTN-CWKQLTHLPKTRP 298
P+ R+ H I F G DG+ + + C K L +L +P
Sbjct: 307 KKNSRPRPRAGHCAVAIGTRLYFWSG---------RDGYKKALNSQVCCKDLWYLDTEKP 357
Score = 57.0 bits (136), Expect = 3e-08
Identities = 63/243 (25%), Positives = 98/243 (40%), Gaps = 51/243 (20%)
Query: 110 WEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGW 169
W +++ F G P R ++ +I FGG G
Sbjct: 9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGN-----------------------EGI 45
Query: 170 HNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR-MNDLHYLN 228
+++H+++T T WF P ++G +PP AAH G + +FGG V R N+L+ L
Sbjct: 46 ADELHVYNTATNQWFLPAVRGDIPP-GCAAHGFVCDGTRILVFGGMVEYGRYSNELYELQ 104
Query: 229 LDTWTW---SGRITINGESPKHRSWHTLTPIADDKLFLCGGL------SADNIP--LSDG 277
W W +G P R H+ + + +K +L GGL S +N+P L+D
Sbjct: 105 ASRWLWKKVKPHPPPSGLPPCPRLGHSFS-LYGNKCYLFGGLANESEDSNNNVPRYLNDF 163
Query: 278 WIHNVTTNCWKQLTHLPKTR-----PRLWHTACL-----GKENEIMVFGG----SKDDLL 323
+ + +P T+ PR HTA + ++ VFGG DDL
Sbjct: 164 YELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLW 223
Query: 324 ALD 326
LD
Sbjct: 224 QLD 226
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 79.3 bits (194), Expect = 6e-15
Identities = 89/342 (26%), Positives = 146/342 (42%), Gaps = 64/342 (18%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
V R GH AV + V+GG NE + DE+ Y+ + W + + G++P
Sbjct: 29 VPRPRHGHRAVAIKELIVVFGG-----GNEGIV--DELHVYNTATNQWFIPAVRGDIPPG 81
Query: 69 MSGSCGACINGKLYIFGGYDDKG-YSNRLYFVNLRTRDETYIWEKI---TDFEGQPPTPR 124
+ C +L +FGG + G YSN LY + + W+++ T G PP PR
Sbjct: 82 CAAYGFVCDGTRLLVFGGMVEYGKYSNDLY----ELQASRWEWKRLKAKTPKNGPPPCPR 137
Query: 125 DKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTK----T 180
S + ++ FGG +D+ + + ND++I + +
Sbjct: 138 LGHSFSLVGNKCYLFGGL-------------ANDSEDPKNNIPRYLNDLYILELRPGSGV 184
Query: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKG------YIFGGRVLQTRMNDLHYLNLDTWTW 234
W P I GV P PR +HT V K I+GG + R+ DL L++DT TW
Sbjct: 185 VAWDIP-ITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGG-MSGCRLGDLWTLDIDTLTW 242
Query: 235 SGRITINGESPKHRSWHTLTPIADDKLFLCGG---LSADNIPLSDGWIHNVTTNCWKQLT 291
+ + +++G +P RS H+ T I +K+++ GG L D++ ++ H C L
Sbjct: 243 N-KPSLSGVAPLPRSLHSATTIG-NKMYVFGGWVPLVMDDVKVA---THEKEWKCTNTL- 296
Query: 292 HLPKTRPRLWHTACLGKEN---EIMVFGGSKDDLLALDTGHC 330
ACL + E ++ +D++ GHC
Sbjct: 297 ------------ACLNLDTMAWETILMDTLEDNIPRARAGHC 326
Score = 76.6 bits (187), Expect = 4e-14
Identities = 84/318 (26%), Positives = 120/318 (37%), Gaps = 79/318 (24%)
Query: 19 VVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCG---- 74
V DG L V+GG V ND Y++ + W ++ + P + C
Sbjct: 88 VCDGTRLLVFGGMVEYGKYS----ND---LYELQASRWEWKRLKAKTPKNGPPPCPRLGH 140
Query: 75 --ACINGKLYIFGGY-----DDKG----YSNRLYFVNLRTRDETYIWEKITDFEGQPPTP 123
+ + K Y+FGG D K Y N LY + LR W+ I G P P
Sbjct: 141 SFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWD-IPITYGVLPPP 199
Query: 124 RDKLSCWVY------KDRLIYFGGY-GCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIF 176
R+ + VY K +L+ +GG GCR D+
Sbjct: 200 RESHTAVVYTEKDNKKSKLVIYGGMSGCRL------------------------GDLWTL 235
Query: 177 DTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR--------------MN 222
D T TW +P + G V P PR+ H+ +GNK Y+FGG V N
Sbjct: 236 DIDTLTWNKPSLSG-VAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTN 294
Query: 223 DLHYLNLDTWTWSGRI--TINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIH 280
L LNLDT W + T+ P+ R+ H I + +L++ G W +
Sbjct: 295 TLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAI-NTRLYIWSGRDG----YRKAWNN 349
Query: 281 NVTTNCWKQLTHLPKTRP 298
V C K L +L +P
Sbjct: 350 QV---CCKDLWYLETEKP 364
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/278 (27%), Positives = 108/278 (38%), Gaps = 55/278 (19%)
Query: 63 GELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPT 122
G +P G I + +FGG ++G + L+ N T W I G P
Sbjct: 27 GPVPRPRHGHRAVAIKELIVVFGG-GNEGIVDELHVYNTATNQ----WF-IPAVRGDIPP 80
Query: 123 PRDKLSCWVYKDRLIYFGG---YGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTK 179
RL+ FGG YG ++S D +++ + WE W K
Sbjct: 81 GCAAYGFVCDGTRLLVFGGMVEYG--KYSN--DLYELQASRWE------WKR----LKAK 126
Query: 180 TQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV---------LQTRMNDLHYLNL- 229
T K G PP PR H+ +++GNK Y+FGG + +NDL+ L L
Sbjct: 127 TP-------KNGPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELR 179
Query: 230 ---DTWTWSGRITINGESPKHRSWHTLTPIAD-----DKLFLCGGLSADNIPLSDGWIHN 281
W IT G P R HT + KL + GG+S L D W +
Sbjct: 180 PGSGVVAWDIPITY-GVLPPPRESHTAVVYTEKDNKKSKLVIYGGMS--GCRLGDLWTLD 236
Query: 282 VTTNCW-KQLTHLPKTRPRLWHTA-CLGKENEIMVFGG 317
+ T W K PR H+A +G N++ VFGG
Sbjct: 237 IDTLTWNKPSLSGVAPLPRSLHSATTIG--NKMYVFGG 272
Score = 28.9 bits (63), Expect = 8.7
Identities = 10/22 (45%), Positives = 13/22 (59%)
Query: 9 VAEERSGHCAVVDGNFLYVWGG 30
+ R+GHCAV LY+W G
Sbjct: 318 IPRARAGHCAVAINTRLYIWSG 339
>gi|62955044 F-box protein 42 [Homo sapiens]
Length = 717
Score = 77.0 bits (188), Expect = 3e-14
Identities = 68/252 (26%), Positives = 117/252 (46%), Gaps = 33/252 (13%)
Query: 66 PASMSGSCGACI---NGKLYIFGGYDDKGYS---NRLYFVNLRTRDETYIWEKITDFEGQ 119
P + S AC N +Y+FGG + N L+ ++L +++ W + G
Sbjct: 115 PITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKE----WIRPLA-SGS 169
Query: 120 PPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTK 179
P+P+ + VYKD L+ FGG+ R S + +H E+ F +++H + +
Sbjct: 170 YPSPKAGATLVVYKDLLVLFGGW--TRPSP----YPLHQP---ERFF----DEIHTY-SP 215
Query: 180 TQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRM-NDLHYLNLDTWTWSGRI 238
++ W+ + PP P A H+ V+ +K +FGG + +M ND+ L+L+ W WS +
Sbjct: 216 SKNWWNCIVTTHGPP-PMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWS-KP 273
Query: 239 TINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWK----QLTHLP 294
I+G SP R + I D + + GG N D W+ ++ + W ++ +
Sbjct: 274 NISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEE 333
Query: 295 KTRPRLW-HTAC 305
P LW H AC
Sbjct: 334 HGAPELWCHPAC 345
Score = 52.0 bits (123), Expect = 1e-06
Identities = 53/235 (22%), Positives = 84/235 (35%), Gaps = 36/235 (15%)
Query: 25 LYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACINGKLYIF 84
+YV+GG N + +++W D++S W L G P+ +G+ L +F
Sbjct: 133 MYVFGGCTQSSCNAAF---NDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLF 189
Query: 85 GGYDDKG----YSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFG 140
GG+ + +F + T + W PP SC V D++I FG
Sbjct: 190 GGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSC-VIDDKMIVFG 248
Query: 141 G-YGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAA 199
G G R+ S NDV + D + W +P I G P PR
Sbjct: 249 GSLGSRQMS----------------------NDVWVLDLEQWAWSKPNI-SGPSPHPRGG 285
Query: 200 HTCAVLGNKGYIF----GGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSW 250
+ V+ + + GG + L +++ W W N E W
Sbjct: 286 QSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELW 340
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 74.3 bits (181), Expect = 2e-13
Identities = 72/261 (27%), Positives = 115/261 (44%), Gaps = 32/261 (12%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R GH V+ + + +WGG N+ + ++ +D+++ W + G +P + G
Sbjct: 77 RYGHSTVLIDDTVLLWGGR-----NDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGH 131
Query: 73 CGACINGKL-YIFGGYDDKG--YSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSC 129
AC+ GK+ YIFGGY+ + +SN ++ ++ T T I K G P RD S
Sbjct: 132 -SACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTK-----GSPARWRDFHSA 185
Query: 130 WVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIK 189
+ + FGG D F ++ E + N + +FDT+T+ W
Sbjct: 186 TMLGSHMYVFGGRA--------DRFGPFHSNNEI-----YCNRIRVFDTRTEAWLDCP-P 231
Query: 190 GGVPPQPRAAHTCAVLGNKGYIFGG--RVLQTRMNDLHYLNLDTWTWSGRITINGESPKH 247
V P+ R +H+ + YIFGG L +DL N ++TW +I G+ P
Sbjct: 232 TPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWK-KIEPKGKGPCP 290
Query: 248 RSWHTLTPIADDKLFLCGGLS 268
R I DK+ L GG S
Sbjct: 291 RR-RQCCCIVGDKIVLFGGTS 310
Score = 68.9 bits (167), Expect = 8e-12
Identities = 86/328 (26%), Positives = 136/328 (41%), Gaps = 54/328 (16%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWR-----MHLMEGE--- 64
R H AV G+ +Y +GGY S ED E L ++ ++ S W + G+
Sbjct: 14 RVNHAAVAVGHRVYSFGGYCSGEDYET-LRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPV 72
Query: 65 LPASMSGSCGACINGKLYIFGGYDD-KGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTP 123
+P G I+ + ++GG +D +G N LY ++ T + +++ G P
Sbjct: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNT--HKWFTPRVS---GTVPGA 127
Query: 124 RDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTW 183
RD S V + FGGY + DCF ND+H DT T TW
Sbjct: 128 RDGHSACVLGKIMYIFGGY-----EQQADCFS---------------NDIHKLDTSTMTW 167
Query: 184 FQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV---------LQTRMNDLHYLNLDTWTW 234
KG P + R H+ +LG+ Y+FGGR + N + + T W
Sbjct: 168 TLICTKGS-PARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW 226
Query: 235 SGRITINGESPKHRSWHTLTPIADDKLFLCGGLSAD-NIPLSDGWIHNVTTNCWKQLTHL 293
P+ R H+ + +L++ GG +A N D W N + WK++
Sbjct: 227 LD-CPPTPVLPEGRRSHSAFGY-NGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIE-- 282
Query: 294 PKTR---PRLWHTACLGKENEIMVFGGS 318
PK + PR C+ ++I++FGG+
Sbjct: 283 PKGKGPCPRRRQCCCI-VGDKIVLFGGT 309
Score = 66.2 bits (160), Expect = 5e-11
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 27/185 (14%)
Query: 10 AEERSGHCAVVDGNFLYVWGGYVSI-----EDNEVYLPNDEIWTYDIDSGLWRMHLMEGE 64
A R H A + G+ +YV+GG +NE+Y + I +D + W
Sbjct: 177 ARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYC--NRIRVFDTRTEAWLDCPPTPV 234
Query: 65 LPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPR 124
LP NG+LYIFGGY+ + NR + + ++ W+KI +G+ P PR
Sbjct: 235 LPEGRRSHSAFGYNGELYIFGGYNAR--LNRHFHDLWKFNPVSFTWKKIEP-KGKGPCPR 291
Query: 125 DKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWF 184
+ C + D+++ FGG L D FD+ D H+D+HI D F
Sbjct: 292 RRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLID-----------HSDLHILD------F 334
Query: 185 QPEIK 189
P +K
Sbjct: 335 SPSLK 339
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 68.6 bits (166), Expect = 1e-11
Identities = 78/322 (24%), Positives = 116/322 (36%), Gaps = 97/322 (30%)
Query: 13 RSGHCAVVDGNFLYVWGGY------VSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELP 66
RSGH V D LYV+GGY DNE Y E+W Y +G+W +G +P
Sbjct: 92 RSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMP 151
Query: 67 ---ASMS--------------------------------------------------GSC 73
ASMS G
Sbjct: 152 RELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQA 211
Query: 74 GACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYK 133
A ING LY+FGG YS L+ ++L TR+ T + + LSC + +
Sbjct: 212 MAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQL-------------KPNNLSCDLPE 258
Query: 134 DRLIYFGGYGCRRHSELQDCFDVH----DASWEEQIFWGWHNDVHIFDTKTQTW----FQ 185
+R RH D ++ SW N +H ++ +T W +
Sbjct: 259 ERY---------RHEIAHDGQRIYILGGGTSWTAYSL----NKIHAYNLETNAWEEIATK 305
Query: 186 PEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESP 245
P K G P R H+C + N +I GG + + D+ LNL T+ W + + P
Sbjct: 306 PHEKIGF-PAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW---VKLPATMP 361
Query: 246 KHRSWHTLTPIADDKLFLCGGL 267
+ +H +++ GG+
Sbjct: 362 EPVYFHCAAVTPAGCMYIHGGV 383
Score = 66.2 bits (160), Expect = 5e-11
Identities = 67/281 (23%), Positives = 113/281 (40%), Gaps = 37/281 (13%)
Query: 66 PASMSGSCGACINGKLYIFGG----YDDKGYSNR----LYFVNLRTRDETYIWEKITDFE 117
P + SG N LY+FGG YD+ G + L+ R T +W ++ +
Sbjct: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQM-GTD 147
Query: 118 GQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFD 177
G P +S ++ + L+ FGG G F + NDVH+ +
Sbjct: 148 GYMPRELASMSLVLHGNNLLVFGGTGIP--------FGESNG-----------NDVHVCN 188
Query: 178 TKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDT--WTWS 235
K + W +G P + A++ Y+FGG DLH L+L+T WT
Sbjct: 189 VKYKRWALLSCRGKKPSR-IYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQL 247
Query: 236 GRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPK 295
++ + P+ R H + L GG S L+ +N+ TN W+++ P
Sbjct: 248 KPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPH 307
Query: 296 TR-----PRLWHTACLGKENEIMVFGGSKDDLLALDTGHCN 331
+ R H +C+ +N++ + GG +++ D N
Sbjct: 308 EKIGFPAARRCH-SCVQIKNDVFICGGYNGEVILGDIWKLN 347
Score = 31.6 bits (70), Expect = 1.3
Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 14/108 (12%)
Query: 11 EERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLW-----RMHLMEGEL 65
EER H DG +Y+ GG S + ++I Y++++ W + H G
Sbjct: 258 EERYRHEIAHDGQRIYILGGGTSWTAYSL----NKIHAYNLETNAWEEIATKPHEKIGFP 313
Query: 66 PASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKI 113
A SC I ++I GGY+ + ++ +NL +T+ W K+
Sbjct: 314 AARRCHSC-VQIKNDVFICGGYNGEVILGDIWKLNL----QTFQWVKL 356
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/154 (29%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 168 GWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTC-AVLGNKGYIFGG---RVLQTRMND 223
G N + + + +T+TW PE+ PP PR HT A +GN+ Y+FGG +
Sbjct: 111 GNRNCLQVLNPETRTWTTPEVTSP-PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTK 169
Query: 224 LHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVT 283
LH + +T TWS T+ G P R H + A KLF+ GGL+ D D +++
Sbjct: 170 LHVFDANTLTWSQPETL-GNPPSPRHGHVMV-AAGTKLFIHGGLAGDRF-YDDLHCIDIS 226
Query: 284 TNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
W++L + + + +FGG
Sbjct: 227 DMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGG 260
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/225 (23%), Positives = 88/225 (39%), Gaps = 41/225 (18%)
Query: 45 EIWTYDIDSGLWRMHLMEGELPASMSGS-CGACINGKLYIFGGYDDKGYSNRLYFVNLRT 103
++ T D+ W + +G LP S +C ++++FGG + G N L +N T
Sbjct: 64 DVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPET 123
Query: 104 RDETYIWEKITDFEGQPPTPRD-KLSCWVYKDRLIYFGGYGCRRHSELQDC----FDVHD 158
R T+ ++T PP+PR S ++L FGG G R +QD FD +
Sbjct: 124 R--TWTTPEVTS---PPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANT 177
Query: 159 ASWEEQIFWG----------------------------WHNDVHIFDTKTQTWFQPEIKG 190
+W + G +++D+H D W Q
Sbjct: 178 LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW-QKLNPT 236
Query: 191 GVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
G P AAH+ +G YIFGG ++ ++ + + W+
Sbjct: 237 GAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWT 281
Score = 52.0 bits (123), Expect = 1e-06
Identities = 43/166 (25%), Positives = 69/166 (41%), Gaps = 6/166 (3%)
Query: 171 NDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLD 230
+DVH D W KG +P A+ + ++ ++FGG N L LN +
Sbjct: 63 SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPE 122
Query: 231 TWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIH--NVTTNCWK 288
T TW+ + P R++HT + ++L++ GG P+ D +H + T W
Sbjct: 123 TRTWT-TPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWS 181
Query: 289 QLTHLPK-TRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDL 333
Q L PR H + ++ + GG D D HC D+
Sbjct: 182 QPETLGNPPSPRHGH-VMVAAGTKLFIHGGLAGDRF-YDDLHCIDI 225
Score = 35.8 bits (81), Expect = 0.071
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 6/85 (7%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R GH V G L++ GG + + Y D++ DI W+ G PA +
Sbjct: 193 RHGHVMVAAGTKLFIHGG---LAGDRFY---DDLHCIDISDMKWQKLNPTGAAPAGCAAH 246
Query: 73 CGACINGKLYIFGGYDDKGYSNRLY 97
+ +YIFGG G + +Y
Sbjct: 247 SAVAMGKHVYIFGGMTPAGALDTMY 271
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 57.0 bits (136), Expect = 3e-08
Identities = 47/191 (24%), Positives = 84/191 (43%), Gaps = 31/191 (16%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
RSGH V L ++GG+ E Y+ ++++ +++D+ W G P SG
Sbjct: 177 RSGHRMVAWKRQLILFGGFH--ESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSG- 233
Query: 73 CGACIN--GKLYIFGGYD--------DKG--YSNRLYFVNLRTRDETYIWEKITDFEGQP 120
C + G + ++GGY DKG +S+ R++ ++W ++ G
Sbjct: 234 CQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNP-SGVK 292
Query: 121 PTPRDKLSCWVYKD-RLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTK 179
PTPR S + + + ++FGG V D EE + + ND++ +D
Sbjct: 293 PTPRSGFSVAMAPNHQTLFFGG--------------VCDEEEEESLSGEFFNDLYFYDAT 338
Query: 180 TQTWFQPEIKG 190
WF+ ++KG
Sbjct: 339 RNRWFEGQLKG 349
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/243 (24%), Positives = 97/243 (39%), Gaps = 40/243 (16%)
Query: 13 RSGHCAVV---DGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASM 69
R H AVV G L+V+GG + + E + ++W + + W G P+
Sbjct: 119 RCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG-PSGR 177
Query: 70 SGSCGACINGKLYIFGGYD----DKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRD 125
SG +L +FGG+ D Y N +Y NL +T+ W K++ G PTPR
Sbjct: 178 SGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNL----DTFTWSKLSP-SGTGPTPRS 232
Query: 126 KLSCWVY-KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIF---DTKTQ 181
V + ++ +GGY +R + DV + H+D+ + D +
Sbjct: 233 GCQMSVTPQGGIVVYGGYSKQRVKK-----DVDKGT--------RHSDMFLLKPEDGRED 279
Query: 182 TWFQPEIK-GGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR---------MNDLHYLNLDT 231
W + GV P PR+ + A+ N +F G V NDL++ +
Sbjct: 280 KWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATR 339
Query: 232 WTW 234
W
Sbjct: 340 NRW 342
Score = 48.1 bits (113), Expect = 1e-05
Identities = 56/210 (26%), Positives = 83/210 (39%), Gaps = 48/210 (22%)
Query: 80 KLYIFGGYDDKGYS----NRLYFVNLRTRDETYIWEKITDFEGQPP---------TPRDK 126
+L +FGG G N LY N TR +T W K+ D PP P+
Sbjct: 77 ELILFGGEYFNGQKTFLYNELYVYN--TRKDT--WTKV-DIPSPPPRRCAHQAVVVPQGG 131
Query: 127 LSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQP 186
WV FGG + E Q + + D+ + T+TW Q
Sbjct: 132 GQLWV-------FGGEFASPNGE--------------QFYH--YKDLWVLHLATKTWEQV 168
Query: 187 EIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTR----MNDLHYLNLDTWTWSGRITING 242
+ GG P R+ H + +FGG TR ND++ NLDT+TWS +++ +G
Sbjct: 169 KSTGG--PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWS-KLSPSG 225
Query: 243 ESPKHRSWHTLTPIADDKLFLCGGLSADNI 272
P RS ++ + + GG S +
Sbjct: 226 TGPTPRSGCQMSVTPQGGIVVYGGYSKQRV 255
Score = 46.2 bits (108), Expect = 5e-05
Identities = 55/237 (23%), Positives = 94/237 (39%), Gaps = 54/237 (22%)
Query: 79 GKLYIFGGY------DDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132
G+L++FGG + + L+ ++L T+ WE++ G ++ W
Sbjct: 132 GQLWVFGGEFASPNGEQFYHYKDLWVLHLATKT----WEQVKSTGGPSGRSGHRMVAW-- 185
Query: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGV 192
K +LI FGG+ H +D ++NDV+ F+ T TW + G
Sbjct: 186 KRQLILFGGF----HESTRDYI--------------YYNDVYAFNLDTFTWSKLS-PSGT 226
Query: 193 PPQPRAAHTCAVLGNKG-YIFGGRVLQ---------TRMNDLHYL-----NLDTWTWSGR 237
P PR+ +V G ++GG Q TR +D+ L D W W+ R
Sbjct: 227 GPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWT-R 285
Query: 238 ITINGESPKHRSWHTLTPIADDKLFLCGGL-------SADNIPLSDGWIHNVTTNCW 287
+ +G P RS ++ + + GG+ S +D + ++ T N W
Sbjct: 286 MNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 47.8 bits (112), Expect = 2e-05
Identities = 76/351 (21%), Positives = 137/351 (39%), Gaps = 70/351 (19%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R+ H AV+ G F++V GGY Y + Y+++S +W + P G
Sbjct: 305 RASHKAVLHGKFMWVIGGYTFN-----YSSFQMVLNYNLESSIWNVGT-PSRGPLQRYGH 358
Query: 73 CGACINGKLYIFGGY---DDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSC 129
A ++++GG +D ++ L+ N+ ++
Sbjct: 359 SLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQS------------------------ 394
Query: 130 WVYKDRLIYFGG--YGCRRHS----ELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTW 183
W K + G Y HS EL V + +G+ + + + + TW
Sbjct: 395 WSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTW 454
Query: 184 FQPEIKGGVPPQPRAAHTCAV--LGNKGYIFGG-RVLQTR----MNDLHYLNLDTWTWSG 236
PE KG + Q HT + Y+ GG + L ++DL+ ++T TW
Sbjct: 455 LVPETKGAI-VQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTW-- 511
Query: 237 RITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG--------WIHNVTTNCWK 288
TI ES R H+ + + + + GG + ++ LS+G +++ + WK
Sbjct: 512 --TILKESGFARYLHSAV-LINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWK 568
Query: 289 QL--THLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQ 337
L +L + R H+A + + +FGG LL ND+L+++
Sbjct: 569 ILPKPNLHRDVNRFGHSAVV-INGSMYIFGGFSSVLL-------NDILVYK 611
Score = 35.4 bits (80), Expect = 0.093
Identities = 27/116 (23%), Positives = 47/116 (40%), Gaps = 14/116 (12%)
Query: 183 WFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQ-TRMNDLHYLNLDTWTWSGRITIN 241
W P +K P RA+H + G ++ GG + + NL++ W+ +
Sbjct: 291 WILPNVKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSSFQMVLNYNLESSIWN--VGTP 348
Query: 242 GESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG------WIHNVTTNCWKQLT 291
P R H+L + + +F+ GG I +DG W+ N+ + W T
Sbjct: 349 SRGPLQRYGHSLA-LYQENIFMYGG----RIETNDGNVTDELWVFNIHSQSWSTKT 399
Score = 31.2 bits (69), Expect = 1.8
Identities = 43/211 (20%), Positives = 79/211 (37%), Gaps = 34/211 (16%)
Query: 12 ERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSG 71
+R GH + ++++GG + D V DE+W ++I S W + P +
Sbjct: 354 QRYGHSLALYQENIFMYGGRIETNDGNV---TDELWVFNIHSQSW-----STKTPTVLG- 404
Query: 72 SCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYI----WEKITDFEGQPPTPRDKL 127
+G+ Y G+ + + L +RD I + I +
Sbjct: 405 ------HGQQYAVEGHS-------AHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISS 451
Query: 128 SCWVYKDR--LIYFGGYG-CRRHSELQDCFDVHDA-SWEEQIFWGWHNDVHIFDTKTQTW 183
+ W+ + I GGYG + E+ VH +G +D++ ++ T+TW
Sbjct: 452 NTWLVPETKGAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTW 511
Query: 184 FQPEIKGGVPPQPRAAHTCAVLGNKGYIFGG 214
+ G R H+ ++ IFGG
Sbjct: 512 TILKESGFA----RYLHSAVLINGAMLIFGG 538
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 44.7 bits (104), Expect = 2e-04
Identities = 38/150 (25%), Positives = 58/150 (38%), Gaps = 17/150 (11%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R G VV +Y GGY + + + YD +G W + SG+
Sbjct: 416 REGAGLVVASGVIYCLGGYDGLNIL------NSVEKYDPHTGHWTNVT---PMATKRSGA 466
Query: 73 CGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132
A +N +Y+ GG+D + + + N+RT W +T TPR + V
Sbjct: 467 GVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDS----WTTVTSM----TTPRCYVGATVL 518
Query: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWE 162
+ RL GY +C+D SWE
Sbjct: 519 RGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
Score = 35.8 bits (81), Expect = 0.071
Identities = 31/143 (21%), Positives = 53/143 (37%), Gaps = 23/143 (16%)
Query: 22 GNFLYVWGGYVSIEDN---EVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACIN 78
G+ +YV GG+ + E Y PN + W+ M G++ + G+ +
Sbjct: 378 GDMIYVSGGFDGSRRHTSMERYDPNIDQWS------------MLGDMQTAREGAGLVVAS 425
Query: 79 GKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIY 138
G +Y GGYD N + + T W +T T R + D +
Sbjct: 426 GVIYCLGGYDGLNILNSVE----KYDPHTGHWTNVTPM----ATKRSGAGVALLNDHIYV 477
Query: 139 FGGYGCRRHSELQDCFDVHDASW 161
GG+ H + +++ SW
Sbjct: 478 VGGFDGTAHLSSVEAYNIRTDSW 500
Score = 29.6 bits (65), Expect = 5.1
Identities = 65/327 (19%), Positives = 112/327 (34%), Gaps = 81/327 (24%)
Query: 25 LYVWGGYVS----IEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACINGK 80
L V GG+ S I+ E Y P + W++ R ++ AS+S ++ +
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYV------ASVS------LHDR 330
Query: 81 LYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFG 140
+Y+ GGYD + + + ++ T DE +W + R D + G
Sbjct: 331 IYVIGGYDGRSRLSSVECLDY-TADEDGVWYSVAPMN----VRRGLAGATTLGDMIYVSG 385
Query: 141 GY-GCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAA 199
G+ G RRH+ ++ +D W G R
Sbjct: 386 GFDGSRRHTSMER-----------------------YDPNIDQWSML----GDMQTAREG 418
Query: 200 HTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIA-- 257
V Y GG + L+ LN ++ P W +TP+A
Sbjct: 419 AGLVVASGVIYCLGG------YDGLNILN----------SVEKYDPHTGHWTNVTPMATK 462
Query: 258 ---------DDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGK 308
+D +++ GG LS +N+ T+ W +T + R + T G+
Sbjct: 463 RSGAGVALLNDHIYVVGGFDG-TAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGR 521
Query: 309 ENEIMVFGGSKDDLLALDTGHCNDLLI 335
I + G+ L + C D +I
Sbjct: 522 LYAIAGYDGNS----LLSSIECYDPII 544
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/266 (24%), Positives = 99/266 (37%), Gaps = 64/266 (24%)
Query: 16 HCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGA 75
HC V NFL+V GG N + N + YD W E AS A
Sbjct: 365 HCVVEVENFLFVLGGEDQWNPNGKHSTNF-VSRYDPRFNSWIQLPPMQERRASFY----A 419
Query: 76 C-INGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKD 134
C ++ LY+ GG ++ GY + + NL T + Y+ P P + V+
Sbjct: 420 CRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYV--------SSLPQPLAAHAGAVHNG 471
Query: 135 RLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPP 194
++ GG VH+ E + W ++ +D W + +
Sbjct: 472 KIYISGG--------------VHNG---EYVPW-----LYCYDPVMDVWARKQDMN---- 505
Query: 195 QPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTL- 253
RA HT AV+ ++ Y GG L+ + +LD + + PK W+ L
Sbjct: 506 TKRAIHTLAVMNDRLYAIGGNHLK------GFSHLDV------MLVECYDPKGDQWNILQ 553
Query: 254 TPI-----------ADDKLFLCGGLS 268
TPI DD ++L GG S
Sbjct: 554 TPILEGRSGPGCAVLDDSIYLVGGYS 579
Score = 43.1 bits (100), Expect = 4e-04
Identities = 57/214 (26%), Positives = 82/214 (38%), Gaps = 46/214 (21%)
Query: 5 QLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGE 64
QL + E R+ A LYV GG + YL + E Y++++ WR
Sbjct: 406 QLPPMQERRASFYACRLDKHLYVIGG----RNETGYLSSVEC--YNLETNEWRY---VSS 456
Query: 65 LPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPR 124
LP ++ GA NGK+YI GG + Y LY + +W + D T R
Sbjct: 457 LPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYD----PVMDVWARKQDMN----TKR 508
Query: 125 DKLSCWVYKDRLIYFGGYGCRRHSELQ----DCFDVHDASWEEQIFWGWHNDVHIFDTKT 180
+ V DRL GG + S L +C+D W +I T
Sbjct: 509 AIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQW------------NILQT-- 554
Query: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGG 214
P ++G R+ CAVL + Y+ GG
Sbjct: 555 -----PILEG------RSGPGCAVLDDSIYLVGG 577
Score = 32.7 bits (73), Expect = 0.60
Identities = 39/161 (24%), Positives = 62/161 (38%), Gaps = 36/161 (22%)
Query: 171 NDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLD 230
N V +D + +TW I P A H + N ++ GG D
Sbjct: 340 NLVQYYDDEKKTWKILTIM----PYNSAHHCVVEVENFLFVLGGE--------------D 381
Query: 231 TWTWSGRITINGES---PKHRSWHTLTPIA-----------DDKLFLCGGLSADNIPLSD 276
W +G+ + N S P+ SW L P+ D L++ GG + LS
Sbjct: 382 QWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGY-LSS 440
Query: 277 GWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
+N+ TN W+ ++ LP +P H + +I + GG
Sbjct: 441 VECYNLETNEWRYVSSLP--QPLAAHAGAV-HNGKIYISGG 478
>gi|31881798 muskelin 1, intracellular mediator containing kelch
motifs isoform 2 [Homo sapiens]
Length = 735
Score = 42.4 bits (98), Expect = 8e-04
Identities = 73/311 (23%), Positives = 121/311 (38%), Gaps = 59/311 (18%)
Query: 13 RSGHCAVVD--GNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMS 70
R GH V+D +Y++GG+ +D + W Y + W + E S
Sbjct: 271 RGGHQMVIDVQTETVYLFGGWDGTQDLA------DFWAYSVKENQWTCISRDTEKENGPS 324
Query: 71 G-SCGA-CIN---GKLYIFGGYDDKGYSNRLYFVN--LRTRDETYIWEKITD---FEGQP 120
SC CI+ ++Y G Y D N + R +T W +++ +G P
Sbjct: 325 ARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGP 384
Query: 121 PTPRDKLSCWVYKDRLIY-FGGYGCRRHSELQDCF-DVHDASWEEQIFWGWHNDVHIFDT 178
D C + +IY FGG + C V D+ E F G + F+
Sbjct: 385 KLVFDHQMCMDSEKHMIYTFGG-------RILTCNGSVDDSRASEPQFSG----LFAFNC 433
Query: 179 KTQTW--FQPEIKGGVPP--QPRAAHTCAVLGNKG---YIFGGRVLQTRMNDLHYLNLD- 230
+ QTW + + P Q R H C + +K Y+FGG+ +T +ND ++D
Sbjct: 434 QCQTWKLLREDSCNAGPEDIQSRIGH-CMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDS 492
Query: 231 ---------TWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG---- 277
T SG + + G + + T+ P ++ + + GLS D +
Sbjct: 493 DHVDIISDGTKKDSGMVPMTGFTQR----ATIDPELNE-IHVLSGLSKDKEKREENVRNS 547
Query: 278 -WIHNVTTNCW 287
WI+++ N W
Sbjct: 548 FWIYDIVRNSW 558
>gi|223890246 muskelin 1, intracellular mediator containing kelch
motifs isoform 1 [Homo sapiens]
Length = 712
Score = 42.4 bits (98), Expect = 8e-04
Identities = 73/311 (23%), Positives = 121/311 (38%), Gaps = 59/311 (18%)
Query: 13 RSGHCAVVD--GNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMS 70
R GH V+D +Y++GG+ +D + W Y + W + E S
Sbjct: 248 RGGHQMVIDVQTETVYLFGGWDGTQDLA------DFWAYSVKENQWTCISRDTEKENGPS 301
Query: 71 G-SCGA-CIN---GKLYIFGGYDDKGYSNRLYFVN--LRTRDETYIWEKITD---FEGQP 120
SC CI+ ++Y G Y D N + R +T W +++ +G P
Sbjct: 302 ARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGP 361
Query: 121 PTPRDKLSCWVYKDRLIY-FGGYGCRRHSELQDCF-DVHDASWEEQIFWGWHNDVHIFDT 178
D C + +IY FGG + C V D+ E F G + F+
Sbjct: 362 KLVFDHQMCMDSEKHMIYTFGG-------RILTCNGSVDDSRASEPQFSG----LFAFNC 410
Query: 179 KTQTW--FQPEIKGGVPP--QPRAAHTCAVLGNKG---YIFGGRVLQTRMNDLHYLNLD- 230
+ QTW + + P Q R H C + +K Y+FGG+ +T +ND ++D
Sbjct: 411 QCQTWKLLREDSCNAGPEDIQSRIGH-CMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDS 469
Query: 231 ---------TWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG---- 277
T SG + + G + + T+ P ++ + + GLS D +
Sbjct: 470 DHVDIISDGTKKDSGMVPMTGFTQR----ATIDPELNE-IHVLSGLSKDKEKREENVRNS 524
Query: 278 -WIHNVTTNCW 287
WI+++ N W
Sbjct: 525 FWIYDIVRNSW 535
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 41.6 bits (96), Expect = 0.001
Identities = 62/278 (22%), Positives = 100/278 (35%), Gaps = 45/278 (16%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYD-IDSGLWRM---HLMEGELPAS 68
R H AV L + GG ++ + L ND +W + + G W + P
Sbjct: 279 RHSHVAVAWAGSLVLMGGELA----DGSLTND-VWAFSPLGRGHWELLAPPASSSSGPPG 333
Query: 69 MSGSCGACINGK-LYIFGGYDDKG-YSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDK 126
++G A ++ LY+ GG +S+ L+ L + Y WE++ G+PP
Sbjct: 334 LAGHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGGY-WEQVIPAGGRPPAATGH 392
Query: 127 LSCWVYKDR-LIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQ 185
+ R L+ GG+ R S + V N +F W
Sbjct: 393 SMVFHAPSRALLVHGGH---RPSTARFSVRV--------------NSTELFHVDRHVWTT 435
Query: 186 PEIKGGVP-PQPRAAHTCAVLGNKGYIFGGRVLQTRMND--------LHYLNLDTWTWSG 236
+ + G+ P+ RA HT +VLGN ++GG V + ++L W
Sbjct: 436 LKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQWVSGA 495
Query: 237 RITING------ESPKHRSWHTLTPIADDKLFLCGGLS 268
+ G P R H + L + GG S
Sbjct: 496 ELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYS 533
Score = 36.2 bits (82), Expect = 0.055
Identities = 25/86 (29%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 210 YIFGGRVL-QTRMNDLHYLNLDTWTWSGRIT---INGESPKHRSWHTLT--PIADDKLFL 263
++FGG L Q + +L+ ++ W+ + G P RS+H P ++L
Sbjct: 1457 WMFGGLGLPQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYL 1516
Query: 264 CGGLSADNIPLSDGWIHNVTTNCWKQ 289
GGL+A + D W+ N+TT W+Q
Sbjct: 1517 LGGLTAGGVT-RDFWVLNLTTLQWRQ 1541
Score = 35.0 bits (79), Expect = 0.12
Identities = 28/85 (32%), Positives = 33/85 (38%), Gaps = 3/85 (3%)
Query: 190 GGVPPQPRAAHTCA-VLGNKG--YIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPK 246
GG P PR+ H A V +G Y+ GG D LNL T W
Sbjct: 1492 GGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFWVLNLTTLQWRQEKAPQTVELP 1551
Query: 247 HRSWHTLTPIADDKLFLCGGLSADN 271
+ HTLT L L GG S +N
Sbjct: 1552 AVAGHTLTARRGLSLLLVGGYSPEN 1576
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/155 (25%), Positives = 56/155 (36%), Gaps = 34/155 (21%)
Query: 12 ERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGEL------ 65
ER+ H A V GN++ V+GG V E D I+ Y + W + EL
Sbjct: 447 ERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQW---VSGAELAPPGTP 503
Query: 66 ------PASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQ 119
P+ A + G + + G GYS R R + + K+ F Q
Sbjct: 504 EGRAAPPSGRYSHVAAVLGGSVLLVAG----GYSG-------RPRGDLMAY-KVPPFVFQ 551
Query: 120 PPTPRDKLS-CWVYKDRLIYFGGYGCRRHSELQDC 153
P P L C +Y D + C R E C
Sbjct: 552 APAPDYHLDYCSMYTDHSV------CSRDPECSWC 580
Score = 30.0 bits (66), Expect = 3.9
Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 7/116 (6%)
Query: 166 FWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGY--IFGGRVLQTRMND 223
F G D+H+++ + W+ R A L G +FGG+ L + D
Sbjct: 197 FLGRACDLHLWENQGAGWWHNVSARDPAFSARIGAAGAFLSPPGLLAVFGGQDLNNALGD 256
Query: 224 LHYLNLDTWTWSGRITINGESPKHRSWHTLTPIA-DDKLFLCGGLSADNIPLSDGW 278
L N TW SP + H+ +A L L GG AD +D W
Sbjct: 257 LVLYNFSANTWESW----DLSPAPAARHSHVAVAWAGSLVLMGGELADGSLTNDVW 308
Score = 29.6 bits (65), Expect = 5.1
Identities = 14/48 (29%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 171 NDVHIFDTKTQTWFQPEIKG----GVPPQPRAAHTCAVLGNKGYIFGG 214
+DV ++ W P++ G P + AH A +G++ YI GG
Sbjct: 1744 SDVLLYQVNCNAWLLPDLTRSASVGPPMEESVAHAVAAVGSRLYISGG 1791
>gi|8922640 kelch domain containing 8A [Homo sapiens]
Length = 350
Score = 41.2 bits (95), Expect = 0.002
Identities = 44/216 (20%), Positives = 83/216 (38%), Gaps = 43/216 (19%)
Query: 79 GKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIY 138
G++Y GG DD G + V D+ W + PT R ++ R++
Sbjct: 31 GQVYAIGGCDDNGVPMDCFEVYSPEADQ---WTALPRL----PTARAGVAVTALGKRIMV 83
Query: 139 FGGYGCRRHS-ELQDCFDVHDASWEEQIFWGW--------------------------HN 171
GG G + ++ + +++ + W+++ HN
Sbjct: 84 IGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGISVTAKDYRVYAAGGMGLDLRPHN 143
Query: 172 DVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDT 231
+ +D W + P PR A T + G+K Y+ GGR + +N +++T
Sbjct: 144 HLQHYDMLKDMW----VSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIET 199
Query: 232 WTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGL 267
+W+ I P R++ + + D+ L+ GGL
Sbjct: 200 RSWTKFPNI----PYKRAFSSFVTL-DNHLYSLGGL 230
Score = 29.6 bits (65), Expect = 5.1
Identities = 33/152 (21%), Positives = 59/152 (38%), Gaps = 21/152 (13%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R+G G + V GG + N+ LP + Y+ID G W+ M E +S +
Sbjct: 69 RAGVAVTALGKRIMVIGG---VGTNQ--LPLKVVEMYNIDEGKWKKRSMLREAAMGISVT 123
Query: 73 CGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFE---GQPPTPRDKLSC 129
+ ++Y GG ++LR + ++ + D PTPR +
Sbjct: 124 AK---DYRVYAAGGMG----------LDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATS 170
Query: 130 WVYKDRLIYFGGYGCRRHSELQDCFDVHDASW 161
++ ++ GG + + FD+ SW
Sbjct: 171 FLRGSKIYVLGGRQSKYAVNAFEVFDIETRSW 202
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 38.5 bits (88), Expect = 0.011
Identities = 59/266 (22%), Positives = 93/266 (34%), Gaps = 52/266 (19%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R H V GNFLYV GG S D + D ++ +D W + L +
Sbjct: 337 RYQHGIAVIGNFLYVVGGQ-SNYDTKGKTAVDTVFRFDPRYNKW---MQVASLNEKRTFF 392
Query: 73 CGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132
+ + G LY GG G + N R + +Y+ + G T VY
Sbjct: 393 HLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGT--------VY 444
Query: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGV 192
+ GG HD + N++ FD T W Q V
Sbjct: 445 GGLMYISGGI-------------THDT---------FQNELMCFDPDTDKWMQKAPMTTV 482
Query: 193 PPQPRAAHTCAVLGNKGYIFGGRVLQTRMN-------DLHYLNLDTWTWSGRITINGESP 245
R H +G+K Y+ GG + + + + LD WT + + G+S
Sbjct: 483 ----RGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAM-LRGQS- 536
Query: 246 KHRSWHTLTPIADDKLFLCGGLSADN 271
+ ++K+++ GG S +N
Sbjct: 537 -----DVGVAVFENKIYVVGGYSWNN 557
Score = 33.1 bits (74), Expect = 0.46
Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 9/86 (10%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
++E GH V G +Y+ GG ++ + +E+ +D D+ W + + +
Sbjct: 432 MSEPHYGHAGTVYGGLMYISGGIT----HDTF--QNELMCFDPDTDKW---MQKAPMTTV 482
Query: 69 MSGSCGACINGKLYIFGGYDDKGYSN 94
C + KLY+ GG +G S+
Sbjct: 483 RGLHCMCTVGDKLYVIGGNHFRGTSD 508
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 37.7 bits (86), Expect = 0.019
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 15/84 (17%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDN---EVYLPNDEIWTYDIDSGLWRMHLMEGELPASM 69
R+GH G LYV GG ED E Y + WT HL LP+
Sbjct: 328 RAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWT----------HL--APLPSPH 375
Query: 70 SGSCGACINGKLYIFGGYDDKGYS 93
G+ A + G+L + GGY + Y+
Sbjct: 376 VGAASAVLQGELLVLGGYSHRTYA 399
Score = 32.3 bits (72), Expect = 0.79
Identities = 66/269 (24%), Positives = 101/269 (37%), Gaps = 65/269 (24%)
Query: 67 ASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDK 126
AS++GS +LY+ GG D +SN L LR WE++ P +
Sbjct: 187 ASLAGS-------ELYVCGGQDFYSHSNTLAST-LRWEPSQEDWEEMA-----PLSQARS 233
Query: 127 LSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQP 186
L V D +Y G G HNDV + +T + P
Sbjct: 234 LFSLVALDGKLYALG--------------------------GRHNDVALDSVET---YNP 264
Query: 187 EIKGGVP----PQPRAAHTCAVLGNKGYIFG--GRVLQTRMNDLHYLNLDTWTWSGRITI 240
E+ P P P AH A+L + Y+ G G Q + +HY ++
Sbjct: 265 ELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHY--------DPKLEK 316
Query: 241 NGE--SPK--HRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKT 296
G SP R+ H + + +L++ GGL LS + + T+ W L LP
Sbjct: 317 PGTFLSPMGVPRAGHVMAALG-GRLYVAGGLGETEDLLSFE-AYELRTDSWTHLAPLPS- 373
Query: 297 RPRLWHTACLGKENEIMVFGGSKDDLLAL 325
P + + + + E++V GG AL
Sbjct: 374 -PHVGAASAV-LQGELLVLGGYSHRTYAL 400
Score = 32.0 bits (71), Expect = 1.0
Identities = 39/142 (27%), Positives = 53/142 (37%), Gaps = 16/142 (11%)
Query: 20 VDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACING 79
+DG LY GG N+V L D + TY+ + +WR LPA A + G
Sbjct: 240 LDGK-LYALGG----RHNDVAL--DSVETYNPELNVWRP---APALPAPCFAHAAAILEG 289
Query: 80 KLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYF 139
+LY+ GG G Y +L D EK F PR RL
Sbjct: 290 QLYVSGGCGGTGQ----YLASLMHYDPKL--EKPGTFLSPMGVPRAGHVMAALGGRLYVA 343
Query: 140 GGYGCRRHSELQDCFDVHDASW 161
GG G + +++ SW
Sbjct: 344 GGLGETEDLLSFEAYELRTDSW 365
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 37.7 bits (86), Expect = 0.019
Identities = 34/147 (23%), Positives = 58/147 (39%), Gaps = 24/147 (16%)
Query: 18 AVVDGNFLYVWGGY---VSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCG 74
AVV+G LY GGY + + E Y P + WT G + + S
Sbjct: 332 AVVNG-LLYAIGGYDGQLRLSTVEAYNPETDTWT------------RVGSMNSKRSAMGT 378
Query: 75 ACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKD 134
++G++Y+ GGYD + + + ET W +T R V++
Sbjct: 379 VVLDGQIYVCGGYDGNSSLSSVETYS----PETDKWTVVTSMSSN----RSAAGVTVFEG 430
Query: 135 RLIYFGGYGCRRHSELQDCFDVHDASW 161
R+ GG+ + + ++ H A+W
Sbjct: 431 RIYVSGGHDGLQIFSSVEHYNHHTATW 457
Score = 33.9 bits (76), Expect = 0.27
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 9/115 (7%)
Query: 203 AVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLF 262
AV+ Y GG Q R++ + N +T TW+ + + K + T+ + D +++
Sbjct: 332 AVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWT---RVGSMNSKRSAMGTV--VLDGQIY 386
Query: 263 LCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
+CGG N LS ++ T+ W +T + R T E I V GG
Sbjct: 387 VCGGYDG-NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF---EGRIYVSGG 437
Score = 30.8 bits (68), Expect = 2.3
Identities = 47/234 (20%), Positives = 81/234 (34%), Gaps = 40/234 (17%)
Query: 75 ACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKD 134
A +NG LY GGYD + + + N ET W ++ G + R + V
Sbjct: 332 AVVNGLLYAIGGYDGQLRLSTVEAYN----PETDTWTRV----GSMNSKRSAMGTVVLDG 383
Query: 135 RLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPP 194
++ GGY +S L + V + +T W
Sbjct: 384 QIYVCGGYD--GNSSL--------------------SSVETYSPETDKWTVVTSMS---- 417
Query: 195 QPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLT 254
R+A V + Y+ GG + + + N T TW + + +H +
Sbjct: 418 SNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGA----- 472
Query: 255 PIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGK 308
K+F+CGG LS +++ + W + + R R+ A G+
Sbjct: 473 ASLGSKMFVCGGYDGSGF-LSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGR 525
Score = 28.9 bits (63), Expect = 8.7
Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 11/83 (13%)
Query: 12 ERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSG 71
+R H A G+ ++V GGY D +L E+++ D + + S+
Sbjct: 466 KRCRHGAASLGSKMFVCGGY----DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVA 521
Query: 72 SCGACINGKLYIFGGYDDKGYSN 94
SCG +LY GGYD G SN
Sbjct: 522 SCG-----RLYAVGGYD--GQSN 537
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 37.7 bits (86), Expect = 0.019
Identities = 37/136 (27%), Positives = 58/136 (42%), Gaps = 23/136 (16%)
Query: 169 WHNDVHI---FDTKTQTWFQPEIKGGVPPQPRA--AHTCAVLGNKGYIFGGRVLQTRMND 223
+HND++ +D T +W V P R AH A L K YI GR + + +
Sbjct: 409 YHNDLNAVERYDPATNSWAY------VAPLKREVYAHAGATLEGKMYITCGRRGEDYLKE 462
Query: 224 LHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNV- 282
H + + TW + P R+WH + + +KL++ GG + D D +H V
Sbjct: 463 THCYDPGSNTWH----TLADGPVRRAWHGMATLL-NKLYVIGGSNNDAGYRRD--VHQVA 515
Query: 283 ----TTNCWKQLTHLP 294
T+ W + LP
Sbjct: 516 CYSCTSGQWSSVCPLP 531
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 37.7 bits (86), Expect = 0.019
Identities = 36/171 (21%), Positives = 67/171 (39%), Gaps = 24/171 (14%)
Query: 8 CVAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPA 67
C AE R + N LYV GG + I++ YL + + Y ++ W+ LP
Sbjct: 370 CTAEFRELYALGSIHNDLYVIGGQMKIKNQ--YLITNCVDKYSVERDNWKR---VSPLPL 424
Query: 68 SMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPT----- 122
++ +N KLY+ GG+ + ++L + + K+ ++
Sbjct: 425 QLACHAVVTVNNKLYVIGGWTPQ--------MDLPDEEPDRLSNKLLQYDPSQDQWSVRA 476
Query: 123 ----PRDKLSCWVYKDRLIYFGGYGC--RRHSELQDCFDVHDASWEEQIFW 167
+ + S V + GG GC + +++ C DV + + FW
Sbjct: 477 PMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFW 527
>gi|27734909 kelch domain containing 8B [Homo sapiens]
Length = 354
Score = 37.7 bits (86), Expect = 0.019
Identities = 32/135 (23%), Positives = 51/135 (37%), Gaps = 19/135 (14%)
Query: 194 PQPRAAHTCAVLGNKGYIFGG-RVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHT 252
P RA VLG + + GG +Q+ + + +D W R T+ +
Sbjct: 66 PTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATL-----PQAAMGV 120
Query: 253 LTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKE--- 309
T D ++ GG+ D P + ++ +CW L +P T C G
Sbjct: 121 ATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMP--------TPCYGASTFL 172
Query: 310 --NEIMVFGGSKDDL 322
N+I V GG + L
Sbjct: 173 HGNKIYVLGGRQGKL 187
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 37.4 bits (85), Expect = 0.025
Identities = 60/266 (22%), Positives = 93/266 (34%), Gaps = 52/266 (19%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R H V GNFLYV GG S D + D ++ +D W + L +
Sbjct: 379 RYQHGIAVIGNFLYVVGGQ-SNYDTKGKTAVDTVFRFDPRYNKW---MQVASLNEKRTFF 434
Query: 73 CGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132
+ + G LY GG + G + N RT + TY+ + G T VY
Sbjct: 435 HLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT--------VY 486
Query: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGV 192
+ GG HD + ++ FD T W Q V
Sbjct: 487 GGVMYISGGI-------------THDT---------FQKELMCFDPDTDKWIQKAPMTTV 524
Query: 193 PPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLN-------LDTWTWSGRITINGESP 245
R H +G + Y+ GG + + L+ LD WT + + G+S
Sbjct: 525 ----RGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAM-LRGQS- 578
Query: 246 KHRSWHTLTPIADDKLFLCGGLSADN 271
+ ++K+++ GG S +N
Sbjct: 579 -----DVGVAVFENKIYVVGGYSWNN 599
Score = 30.4 bits (67), Expect = 3.0
Identities = 19/86 (22%), Positives = 37/86 (43%), Gaps = 9/86 (10%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
++E GH V G +Y+ GG ++ + E+ +D D+ W + + +
Sbjct: 474 MSEPHYGHAGTVYGGVMYISGGIT----HDTF--QKELMCFDPDTDKW---IQKAPMTTV 524
Query: 69 MSGSCGACINGKLYIFGGYDDKGYSN 94
C + +LY+ GG +G S+
Sbjct: 525 RGLHCMCTVGERLYVIGGNHFRGTSD 550
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 37.4 bits (85), Expect = 0.025
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 18 AVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASM-SGSCGAC 76
A DG FLY GG+ + N D + YD + W M P SM + G C
Sbjct: 643 ATCDG-FLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTM-----VAPLSMPRDAVGVC 696
Query: 77 ING-KLYIFGGYDDKGYSNRLYFVNLRTRDET 107
+ G +LY GGYD + Y N + + +T + T
Sbjct: 697 LLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
Score = 32.7 bits (73), Expect = 0.60
Identities = 28/112 (25%), Positives = 44/112 (39%), Gaps = 17/112 (15%)
Query: 176 FDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
+D +T W Q + G R AV+ +K ++ GGR +N + N T TW
Sbjct: 479 YDLRTNLWIQAGMMNG----RRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTW- 533
Query: 236 GRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCW 287
T+ HR +T + + ++ GG DGW + T W
Sbjct: 534 ---TVLPPMSTHRHGLGVT-VLEGPIYAVGG--------HDGWSYLNTVERW 573
Score = 32.3 bits (72), Expect = 0.79
Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 6/91 (6%)
Query: 75 ACINGKLYIFGGYDD--KGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVY 132
A +G LY GG+D + +RL R +T W + PRD + +
Sbjct: 643 ATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLS----MPRDAVGVCLL 698
Query: 133 KDRLIYFGGYGCRRHSELQDCFDVHDASWEE 163
DRL GGY + + + +D W +
Sbjct: 699 GDRLYAVGGYDGQTYLNTMESYDPQTNEWTQ 729
Score = 32.0 bits (71), Expect = 1.0
Identities = 49/201 (24%), Positives = 71/201 (35%), Gaps = 36/201 (17%)
Query: 47 WTYDIDSGLWRMHLMEGELPASMS---GSCG-ACINGKLYIFGGYDDKGYSNRLYFVNLR 102
W+Y W + ASMS + G A +NGKLY GG D + + + +
Sbjct: 564 WSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYD-- 621
Query: 103 TRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWE 162
P T + + + K R GG G HDA
Sbjct: 622 -----------------PHTNKWNMCAPMCKRR----GGVGVATCDGFLYAVGGHDAPAS 660
Query: 163 EQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPP--QPRAAHTCAVLGNKGYIFGGRVLQTR 220
+ V +D KT TW V P PR A +LG++ Y GG QT
Sbjct: 661 NHCS-RLLDYVERYDPKTDTWTM------VAPLSMPRDAVGVCLLGDRLYAVGGYDGQTY 713
Query: 221 MNDLHYLNLDTWTWSGRITIN 241
+N + + T W+ ++N
Sbjct: 714 LNTMESYDPQTNEWTQMASLN 734
Score = 31.2 bits (69), Expect = 1.8
Identities = 44/190 (23%), Positives = 69/190 (36%), Gaps = 43/190 (22%)
Query: 49 YDIDSGLWRMHLMEGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETY 108
YD+ + LW + G + A I+ KL++ GG D N + N +T+ T
Sbjct: 479 YDLRTNLW---IQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
Query: 109 IWEKITDFEGQPP--TPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIF 166
+ PP T R L V + + GG HD
Sbjct: 536 L----------PPMSTHRHGLGVTVLEGPIYAVGG---------------HDG------- 563
Query: 167 WGWHNDVHIFDTKTQTW-FQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLH 225
W + N V +D ++Q W F + R+ A L K Y GGR + ++ +
Sbjct: 564 WSYLNTVERWDPQSQQWTFVASMS-----IARSTVGVAALNGKLYSVGGRDGSSCLSSME 618
Query: 226 YLNLDTWTWS 235
Y + T W+
Sbjct: 619 YYDPHTNKWN 628
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 37.4 bits (85), Expect = 0.025
Identities = 37/153 (24%), Positives = 63/153 (41%), Gaps = 29/153 (18%)
Query: 16 HCAVVDGNFLYVWGGY---VSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
HCAV G +Y GGY E+ E Y P E W + ++++G G+
Sbjct: 362 HCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKW-------IPIANMIKG------VGN 408
Query: 73 CGACI-NGKLYIFGGYDDKGYSNRLYFVNLRT-RDETYIWEKITDFEGQPPTPRDKLSCW 130
AC+ + +Y+ GG+ GY + +++ + W IT P P L
Sbjct: 409 ATACVLHDVIYVIGGH--CGYRGSCTYDKVQSYNSDINEWSLIT----SSPHPEYGLCSV 462
Query: 131 VYKDRLIYFGGYGCRRHSELQDCFDVHDASWEE 163
++++L GG + + +C+D W E
Sbjct: 463 PFENKLYLVGG-----QTTITECYDPEQNEWRE 490
Score = 30.4 bits (67), Expect = 3.0
Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Query: 273 PLSDGWIHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGGSK-DDLLALDT 327
PLS+ I + TN W Q +P + CLG I V GG + D++ ALDT
Sbjct: 285 PLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGP--NIYVTGGYRTDNIEALDT 338
Score = 30.0 bits (66), Expect = 3.9
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 5/48 (10%)
Query: 169 WH--NDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGG 214
WH ++VHI+D T W Q +P R ++ LG Y+ GG
Sbjct: 283 WHPLSEVHIWDPLTNVWIQ---GAEIPDYTRESYGVTCLGPNIYVTGG 327
>gi|21450863 attractin isoform 2 [Homo sapiens]
Length = 1272
Score = 36.6 bits (83), Expect = 0.042
Identities = 76/357 (21%), Positives = 135/357 (37%), Gaps = 57/357 (15%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R+ H AVV+GN ++V GGY+ + + + YD+ S W G
Sbjct: 341 RASHKAVVNGNIMWVVGGYMFNHSD-----YNMVLAYDLASREWLPLNRSVNNVVVRYGH 395
Query: 73 CGACINGKLYIFGGYDDK--GYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCW 130
A K+Y++GG D +N L ++ W +T P +++ +
Sbjct: 396 SLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNES----WVLLT------PKAKEQYAVV 445
Query: 131 VYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWF-----Q 185
+ ++ L++ V + +G+ ++V +D TW
Sbjct: 446 GHSAHIV-----------TLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQG 494
Query: 186 PEIKGGVPPQPRAAH-TCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGES 244
++GG H T A+ + GY +DL+ ++DT W TI +S
Sbjct: 495 ALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMW----TILKDS 550
Query: 245 PKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG--------WIHNVTTNCWKQLTH--LP 294
R HT I + + GG + ++ +S G +++ + W L L
Sbjct: 551 RFFRYLHTAV-IVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLH 609
Query: 295 KTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCI 351
R H+A L + + VFGG LL +D+L+F ++ RS C+
Sbjct: 610 HDVNRFGHSAVL-HNSTMYVFGGFNSLLL-------SDILVFTSEQCDAHRSEAACL 658
>gi|21450861 attractin isoform 1 [Homo sapiens]
Length = 1429
Score = 36.6 bits (83), Expect = 0.042
Identities = 76/357 (21%), Positives = 135/357 (37%), Gaps = 57/357 (15%)
Query: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
R+ H AVV+GN ++V GGY+ + + + YD+ S W G
Sbjct: 341 RASHKAVVNGNIMWVVGGYMFNHSD-----YNMVLAYDLASREWLPLNRSVNNVVVRYGH 395
Query: 73 CGACINGKLYIFGGYDDK--GYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCW 130
A K+Y++GG D +N L ++ W +T P +++ +
Sbjct: 396 SLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNES----WVLLT------PKAKEQYAVV 445
Query: 131 VYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWF-----Q 185
+ ++ L++ V + +G+ ++V +D TW
Sbjct: 446 GHSAHIV-----------TLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQG 494
Query: 186 PEIKGGVPPQPRAAH-TCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGES 244
++GG H T A+ + GY +DL+ ++DT W TI +S
Sbjct: 495 ALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMW----TILKDS 550
Query: 245 PKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG--------WIHNVTTNCWKQLTH--LP 294
R HT I + + GG + ++ +S G +++ + W L L
Sbjct: 551 RFFRYLHTAV-IVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLH 609
Query: 295 KTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLIFQTQPYSLLRSCLDCI 351
R H+A L + + VFGG LL +D+L+F ++ RS C+
Sbjct: 610 HDVNRFGHSAVL-HNSTMYVFGGFNSLLL-------SDILVFTSEQCDAHRSEAACL 658
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 36.6 bits (83), Expect = 0.042
Identities = 30/105 (28%), Positives = 46/105 (43%), Gaps = 11/105 (10%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
+++ R G LY GG+ + N +D + YD + +W AS
Sbjct: 595 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA-------VAS 647
Query: 69 MSGS---CGACING-KLYIFGGYDDKGYSNRLYFVNLRTRDETYI 109
MS S G C+ G KLY GGYD + Y N + + +T + T +
Sbjct: 648 MSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 692
Score = 33.9 bits (76), Expect = 0.27
Identities = 34/146 (23%), Positives = 52/146 (35%), Gaps = 22/146 (15%)
Query: 18 AVVDGNFLYVWG--GYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGA 75
AV+D V G G ++ E Y P + W+ + + G A
Sbjct: 464 AVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWS------------VMPPMSTHRHGLGVA 511
Query: 76 CINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDR 135
+ G +Y GG+D Y N + + + R W +F TPR + V +
Sbjct: 512 VLEGPMYAVGGHDGWSYLNTVERWDPQARQ----W----NFVATMSTPRSTVGVAVLSGK 563
Query: 136 LIYFGGYGCRRHSELQDCFDVHDASW 161
L GG + +CFD H W
Sbjct: 564 LYAVGGRDGSSCLKSVECFDPHTNKW 589
Score = 30.4 bits (67), Expect = 3.0
Identities = 37/154 (24%), Positives = 56/154 (36%), Gaps = 28/154 (18%)
Query: 18 AVVDGNFLYVWG--GYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMS---GS 72
AV+ G V G G ++ E + P+ WT L A MS G
Sbjct: 558 AVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWT----------------LCAQMSKRRGG 601
Query: 73 CGACI-NGKLYIFGGYDD--KGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSC 129
G NG LY GG+D ++RL R +T +W + RD +
Sbjct: 602 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS----ISRDAVGV 657
Query: 130 WVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEE 163
+ D+L GGY + + + +D W +
Sbjct: 658 CLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 691
Score = 29.3 bits (64), Expect = 6.7
Identities = 30/113 (26%), Positives = 42/113 (37%), Gaps = 19/113 (16%)
Query: 176 FDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
+D +T W G R AVL +K Y+ GGR +N + N T TWS
Sbjct: 441 YDLRTNMWTPVANMNG----RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWS 496
Query: 236 GRITINGESPKHRSWHTL-TPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCW 287
+ HR H L + + ++ GG DGW + T W
Sbjct: 497 ----VMPPMSTHR--HGLGVAVLEGPMYAVGG--------HDGWSYLNTVERW 535
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 36.6 bits (83), Expect = 0.042
Identities = 30/105 (28%), Positives = 46/105 (43%), Gaps = 11/105 (10%)
Query: 9 VAEERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPAS 68
+++ R G LY GG+ + N +D + YD + +W AS
Sbjct: 580 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA-------VAS 632
Query: 69 MSGS---CGACING-KLYIFGGYDDKGYSNRLYFVNLRTRDETYI 109
MS S G C+ G KLY GGYD + Y N + + +T + T +
Sbjct: 633 MSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 677
Score = 33.9 bits (76), Expect = 0.27
Identities = 34/146 (23%), Positives = 52/146 (35%), Gaps = 22/146 (15%)
Query: 18 AVVDGNFLYVWG--GYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGA 75
AV+D V G G ++ E Y P + W+ + + G A
Sbjct: 449 AVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWS------------VMPPMSTHRHGLGVA 496
Query: 76 CINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDR 135
+ G +Y GG+D Y N + + + R W +F TPR + V +
Sbjct: 497 VLEGPMYAVGGHDGWSYLNTVERWDPQARQ----W----NFVATMSTPRSTVGVAVLSGK 548
Query: 136 LIYFGGYGCRRHSELQDCFDVHDASW 161
L GG + +CFD H W
Sbjct: 549 LYAVGGRDGSSCLKSVECFDPHTNKW 574
Score = 30.4 bits (67), Expect = 3.0
Identities = 37/154 (24%), Positives = 56/154 (36%), Gaps = 28/154 (18%)
Query: 18 AVVDGNFLYVWG--GYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMS---GS 72
AV+ G V G G ++ E + P+ WT L A MS G
Sbjct: 543 AVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWT----------------LCAQMSKRRGG 586
Query: 73 CGACI-NGKLYIFGGYDD--KGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSC 129
G NG LY GG+D ++RL R +T +W + RD +
Sbjct: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS----ISRDAVGV 642
Query: 130 WVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEE 163
+ D+L GGY + + + +D W +
Sbjct: 643 CLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 676
Score = 29.3 bits (64), Expect = 6.7
Identities = 30/113 (26%), Positives = 42/113 (37%), Gaps = 19/113 (16%)
Query: 176 FDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
+D +T W G R AVL +K Y+ GGR +N + N T TWS
Sbjct: 426 YDLRTNMWTPVANMNG----RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWS 481
Query: 236 GRITINGESPKHRSWHTL-TPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCW 287
+ HR H L + + ++ GG DGW + T W
Sbjct: 482 ----VMPPMSTHR--HGLGVAVLEGPMYAVGG--------HDGWSYLNTVERW 520
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.467
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,212,552
Number of Sequences: 37866
Number of extensions: 874735
Number of successful extensions: 1966
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 1673
Number of HSP's gapped (non-prelim): 263
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.