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Search of human proteins with 254039650
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
(730 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 1466 0.0
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 1466 0.0
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 1453 0.0
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 496 e-140
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 496 e-140
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 271 2e-72
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 271 2e-72
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 263 4e-70
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens] 260 4e-69
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens] 260 4e-69
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 259 6e-69
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens] 259 6e-69
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens] 254 2e-67
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens] 251 2e-66
gi|14249614 synaptotagmin-like 1 [Homo sapiens] 234 2e-61
gi|110227631 synaptotagmin-like 3 [Homo sapiens] 221 2e-57
gi|92859638 synaptotagmin V [Homo sapiens] 129 1e-29
gi|211059429 synaptotagmin II [Homo sapiens] 124 4e-28
gi|31543670 synaptotagmin II [Homo sapiens] 124 4e-28
gi|6005997 double C2-like domains, beta [Homo sapiens] 117 3e-26
gi|209447073 synaptotagmin I [Homo sapiens] 116 6e-26
gi|5032139 synaptotagmin I [Homo sapiens] 116 6e-26
gi|209447070 synaptotagmin I [Homo sapiens] 116 6e-26
gi|38570146 synaptotagmin VII [Homo sapiens] 112 9e-25
gi|47078261 double C2-like domains, alpha [Homo sapiens] 108 1e-23
gi|238550198 synaptotagmin III [Homo sapiens] 108 2e-23
gi|238550196 synaptotagmin III [Homo sapiens] 108 2e-23
gi|14150054 synaptotagmin III [Homo sapiens] 108 2e-23
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 105 1e-22
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 105 1e-22
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 1466 bits (3795), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA
Sbjct: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
Query: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF
Sbjct: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
Query: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND
Sbjct: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
Query: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS
Sbjct: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
Query: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET
Sbjct: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
Query: 361 EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT
Sbjct: 361 EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
Query: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT 480
GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT
Sbjct: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT 480
Query: 481 ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG 540
ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG
Sbjct: 481 ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG 540
Query: 541 LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT 600
LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT
Sbjct: 541 LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT 600
Query: 601 AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL 660
AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL
Sbjct: 601 AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL 660
Query: 661 TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM 720
TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM
Sbjct: 661 TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM 720
Query: 721 LRSSMGKCRL 730
LRSSMGKCRL
Sbjct: 721 LRSSMGKCRL 730
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 1466 bits (3795), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA
Sbjct: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
Query: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF
Sbjct: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
Query: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND
Sbjct: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
Query: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS
Sbjct: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
Query: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET
Sbjct: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
Query: 361 EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT
Sbjct: 361 EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
Query: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT 480
GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT
Sbjct: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT 480
Query: 481 ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG 540
ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG
Sbjct: 481 ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG 540
Query: 541 LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT 600
LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT
Sbjct: 541 LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT 600
Query: 601 AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL 660
AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL
Sbjct: 601 AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL 660
Query: 661 TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM 720
TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM
Sbjct: 661 TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM 720
Query: 721 LRSSMGKCRL 730
LRSSMGKCRL
Sbjct: 721 LRSSMGKCRL 730
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 1453 bits (3762), Expect = 0.0
Identities = 730/752 (97%), Positives = 730/752 (97%), Gaps = 22/752 (2%)
Query: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA
Sbjct: 1 MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA 60
Query: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF
Sbjct: 61 SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF 120
Query: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG 180
Query: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND
Sbjct: 181 PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND 240
Query: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS
Sbjct: 241 QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS 300
Query: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET
Sbjct: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET 360
Query: 361 EESIDALVSSQLSTNTHRLASGLS----------------------TTSLNSMMSVYSET 398
EESIDALVSSQLSTNTHRLASGLS TTSLNSMMSVYSET
Sbjct: 361 EESIDALVSSQLSTNTHRLASGLSTSSQAGSDRKWTYLNVPDADSDTTSLNSMMSVYSET 420
Query: 399 GDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRN 458
GDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRN
Sbjct: 421 GDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRN 480
Query: 459 NKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWN 518
NKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWN
Sbjct: 481 NKRKTKIRTGTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWN 540
Query: 519 FENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKK 578
FENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKK
Sbjct: 541 FENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKK 600
Query: 579 KESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQ 638
KESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQ
Sbjct: 601 KESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQ 660
Query: 639 WNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQG 698
WNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQG
Sbjct: 661 WNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQG 720
Query: 699 EEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL 730
EEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL
Sbjct: 721 EEQRLWQKMANNPGTPFEGVLMLRSSMGKCRL 752
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 496 bits (1277), Expect = e-140
Identities = 296/732 (40%), Positives = 420/732 (57%), Gaps = 70/732 (9%)
Query: 5 SEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGK--TQQEASR 62
SE ++LSFL + EK++IL VL+RDE ++K ++KRIR+LKNELLE KR+ K +Q + R
Sbjct: 2 SELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR 61
Query: 63 VCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFE 122
C C +LG + + + C+ C+ VCR+CR+ NG+W+C VC K +L+ TG+WF++
Sbjct: 62 TCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYD 121
Query: 123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQT-RQDAEKSDTSPVAGKKASHDGP 181
+K RF G++++R S LR P + ++ Q+ + D P G+K +
Sbjct: 122 QKVNRFAYRT--GSEIIRMS-LRHKPAVSKRETVGQSLLHQTQMGDIWP--GRKIIQERQ 176
Query: 182 KRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ 241
K L PK +G+S +L+ + + S +D ST D D+
Sbjct: 177 KEPSVLFE-----------VPKLKSGKS-ALEAESESLDSFT----ADSDSTSRRDSLDK 220
Query: 242 EPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSH 301
+G+ P + AP ++ + G +N + + E ++ T+
Sbjct: 221 ------------SGLFPEWKKMSAPKSQVEKET---QPGGQNVVFVDEGEMIFKKNTRKI 265
Query: 302 RRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETE 361
R S+ ++S +DL ++ RSKSVPG EE E
Sbjct: 266 LR---------------PSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEE 310
Query: 362 ESIDALVS-SQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
E ID LV + + SG S +++ SMMS+YSE GD+GN+ V+G I + Y +T
Sbjct: 311 EDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQT 370
Query: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKY 479
L + VK C LA DE K+R++ YVK+YLLPDKSR KRKT I+ T NP ++ETL+Y
Sbjct: 371 QSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY 430
Query: 480 TISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDI 539
I + L RTLQ SVWH+ RFGRN+FLGE EI DSW + D L K+
Sbjct: 431 EIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 540 GL-QYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKN 598
GL +KGEL V L+YIP +KT G +K+S GG L+V+IKEAKN
Sbjct: 491 GLPSHKGELVVSLKYIP-------------ASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
Query: 599 LTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCL 658
LTA K+GGTSDSFVKGYLLP +KA+K KT V+KK++NP +NHTF+++G+ +D++++CL
Sbjct: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
Query: 659 ELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGV 718
ELT+WD+E +SN FLGGVRL G+G+S+G+ VDWMDS GEE LWQKM PG+ EG
Sbjct: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGT 657
Query: 719 LMLRSSMGKCRL 730
L LRSSM K +L
Sbjct: 658 LQLRSSMAKQKL 669
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 496 bits (1277), Expect = e-140
Identities = 296/732 (40%), Positives = 420/732 (57%), Gaps = 70/732 (9%)
Query: 5 SEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGK--TQQEASR 62
SE ++LSFL + EK++IL VL+RDE ++K ++KRIR+LKNELLE KR+ K +Q + R
Sbjct: 2 SELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR 61
Query: 63 VCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFE 122
C C +LG + + + C+ C+ VCR+CR+ NG+W+C VC K +L+ TG+WF++
Sbjct: 62 TCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYD 121
Query: 123 EKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQT-RQDAEKSDTSPVAGKKASHDGP 181
+K RF G++++R S LR P + ++ Q+ + D P G+K +
Sbjct: 122 QKVNRFAYRT--GSEIIRMS-LRHKPAVSKRETVGQSLLHQTQMGDIWP--GRKIIQERQ 176
Query: 182 KRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQ 241
K L PK +G+S +L+ + + S +D ST D D+
Sbjct: 177 KEPSVLFE-----------VPKLKSGKS-ALEAESESLDSFT----ADSDSTSRRDSLDK 220
Query: 242 EPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSH 301
+G+ P + AP ++ + G +N + + E ++ T+
Sbjct: 221 ------------SGLFPEWKKMSAPKSQVEKET---QPGGQNVVFVDEGEMIFKKNTRKI 265
Query: 302 RRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETE 361
R S+ ++S +DL ++ RSKSVPG EE E
Sbjct: 266 LR---------------PSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEE 310
Query: 362 ESIDALVS-SQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT 420
E ID LV + + SG S +++ SMMS+YSE GD+GN+ V+G I + Y +T
Sbjct: 311 EDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQT 370
Query: 421 GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKY 479
L + VK C LA DE K+R++ YVK+YLLPDKSR KRKT I+ T NP ++ETL+Y
Sbjct: 371 QSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY 430
Query: 480 TISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDI 539
I + L RTLQ SVWH+ RFGRN+FLGE EI DSW + D L K+
Sbjct: 431 EIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 540 GL-QYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKN 598
GL +KGEL V L+YIP +KT G +K+S GG L+V+IKEAKN
Sbjct: 491 GLPSHKGELVVSLKYIP-------------ASKTPVGGDRKKSKGGEGGELQVWIKEAKN 537
Query: 599 LTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCL 658
LTA K+GGTSDSFVKGYLLP +KA+K KT V+KK++NP +NHTF+++G+ +D++++CL
Sbjct: 538 LTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCL 597
Query: 659 ELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGV 718
ELT+WD+E +SN FLGGVRL G+G+S+G+ VDWMDS GEE LWQKM PG+ EG
Sbjct: 598 ELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGT 657
Query: 719 LMLRSSMGKCRL 730
L LRSSM K +L
Sbjct: 658 LQLRSSMAKQKL 669
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 271 bits (692), Expect = 2e-72
Identities = 202/622 (32%), Positives = 314/622 (50%), Gaps = 80/622 (12%)
Query: 130 QVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAE-----KSDTSPVAGKKASHDGPKRK 184
+ +VL +D ++ + + EE QS + Q + +S +SP K +H
Sbjct: 356 EFSVLESDRLKNG-MEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSG 414
Query: 185 GFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPG 244
F ++ S E++T + +S+++ P + SS+L E
Sbjct: 415 SFPINGLHS--HSEVLTARP---------------QSMENSPTINEPKDKSSELTRLESV 457
Query: 245 -PRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFEN--SMDLAAIE-GTSQELTKS 300
PR+P S+ V P P S+R R+ G E S L +E ++++
Sbjct: 458 LPRSPADELSHCVEPEPSQVPGGSSR------DRQQGSEEEPSPVLKTLERSAARKMPSK 511
Query: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSE-----DTVSIRSKSVPGALDKD 355
+ S S + + RS D+S T+ D + SKSVP L +
Sbjct: 512 SLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDE 571
Query: 356 SLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM----MSVYSETGDYGNVK 405
S ++ E + S QLS ++ L+S TSL+S+ MSVYS GD+GN++
Sbjct: 572 S-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLE 628
Query: 406 VSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI 465
V G I I Y L++FV C++LA D KKQR+D YVK+YLLPDK + K+KT +
Sbjct: 629 VKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLV 688
Query: 466 RTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTD 524
T NP +NE L+Y I L+T+ L LS+WH D F RNSFLGEVE+ ++W+++N +
Sbjct: 689 VKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQN 748
Query: 525 E---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKE 580
+ W+ L+ K AP + + +GE+ + L+Y+ PE + G K
Sbjct: 749 KQLRWYPLKRKT--APVALEAENRGEMKLALQYV---------PEPVPGKK--------- 788
Query: 581 SPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWN 640
+ + G + +++KE +L ++ G +SFVK +LPD S+ ++ KT + K+ NP +N
Sbjct: 789 --LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFN 845
Query: 641 HTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEE 700
HT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+G S+G VDWMDS EE
Sbjct: 846 HTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEE 904
Query: 701 QRLWQKMANNPGTPFEGVLMLR 722
LW+KM N+P T E L LR
Sbjct: 905 VALWEKMVNSPNTWIEATLPLR 926
Score = 41.2 bits (95), Expect = 0.003
Identities = 23/56 (41%), Positives = 36/56 (64%), Gaps = 3/56 (5%)
Query: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNEL---LEAKRRSGKTQQEA 60
I+LSFL + E+E I+ VL+RD LK+ E++R+R L ++ + K SG+ EA
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEA 57
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/263 (21%), Positives = 112/263 (42%), Gaps = 32/263 (12%)
Query: 111 QLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSP 170
QL+ ++G+WF+E KAKR + + G D++R S+ ++ P QS+++ A++S +
Sbjct: 45 QLKNMSGQWFYEAKAKRHRD-KIHGADIIRASMRKKRPQIAAEQSKDR-ENGAKESWVNN 102
Query: 171 VAGKKASHDGPKRKGFLLSKFRSAT----RGEIITPKTDTGRSYSLDLDGQHFRSLK-SP 225
V K + P+ G + A ++ P + +D+ ++ R SP
Sbjct: 103 V--NKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSV-----IDMSQENTRKPNVSP 155
Query: 226 PGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSM 285
+ SS L + +T NG RT S+E S
Sbjct: 156 EKQRKNPFNSSKLPEGHSSQQTKNEQSKNG-------------RTGLFQTSKEDELSESK 202
Query: 286 DLAAIEGTS-QELTKSHRR---NTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTV 341
+ + + TS Q+L KS + ++G+ A + ++L+ ++ + + T
Sbjct: 203 EKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTD 262
Query: 342 SIRSKSVP-GALDKDSLEETEES 363
S++++ P G L ++S + +S
Sbjct: 263 SLKARGAPRGILKRNSSSSSTDS 285
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 271 bits (692), Expect = 2e-72
Identities = 202/622 (32%), Positives = 314/622 (50%), Gaps = 80/622 (12%)
Query: 130 QVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAE-----KSDTSPVAGKKASHDGPKRK 184
+ +VL +D ++ + + EE QS + Q + +S +SP K +H
Sbjct: 355 EFSVLESDRLKNG-MEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSG 413
Query: 185 GFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPG 244
F ++ S E++T + +S+++ P + SS+L E
Sbjct: 414 SFPINGLHS--HSEVLTARP---------------QSMENSPTINEPKDKSSELTRLESV 456
Query: 245 -PRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFEN--SMDLAAIE-GTSQELTKS 300
PR+P S+ V P P S+R R+ G E S L +E ++++
Sbjct: 457 LPRSPADELSHCVEPEPSQVPGGSSR------DRQQGSEEEPSPVLKTLERSAARKMPSK 510
Query: 301 HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSE-----DTVSIRSKSVPGALDKD 355
+ S S + + RS D+S T+ D + SKSVP L +
Sbjct: 511 SLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDE 570
Query: 356 SLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM----MSVYSETGDYGNVK 405
S ++ E + S QLS ++ L+S TSL+S+ MSVYS GD+GN++
Sbjct: 571 S-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLE 627
Query: 406 VSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI 465
V G I I Y L++FV C++LA D KKQR+D YVK+YLLPDK + K+KT +
Sbjct: 628 VKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLV 687
Query: 466 RTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTD 524
T NP +NE L+Y I L+T+ L LS+WH D F RNSFLGEVE+ ++W+++N +
Sbjct: 688 VKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQN 747
Query: 525 E---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKE 580
+ W+ L+ K AP + + +GE+ + L+Y+ PE + G K
Sbjct: 748 KQLRWYPLKRKT--APVALEAENRGEMKLALQYV---------PEPVPGKK--------- 787
Query: 581 SPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWN 640
+ + G + +++KE +L ++ G +SFVK +LPD S+ ++ KT + K+ NP +N
Sbjct: 788 --LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFN 844
Query: 641 HTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEE 700
HT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+G S+G VDWMDS EE
Sbjct: 845 HTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEE 903
Query: 701 QRLWQKMANNPGTPFEGVLMLR 722
LW+KM N+P T E L LR
Sbjct: 904 VALWEKMVNSPNTWIEATLPLR 925
Score = 43.1 bits (100), Expect = 0.001
Identities = 55/262 (20%), Positives = 111/262 (42%), Gaps = 31/262 (11%)
Query: 111 QLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSP 170
QL+ ++G+WF+E KAKR + + G D++R S+ ++ P QS+++ A++S +
Sbjct: 45 QLKNMSGQWFYEAKAKRHRD-KIHGADIIRASMRKKRPQIAAEQSKDR-ENGAKESWVNN 102
Query: 171 VAGKKASHDGPKRKGFLLSKFRSAT----RGEIITPKTDTGRSYSLDLDGQHFRSLKSPP 226
V K + P+ G + A ++ P + +D+ ++ R P
Sbjct: 103 V--NKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSV-----IDMSQENTRKPNVSP 155
Query: 227 GSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMD 286
+ SS L + +T NG RT S+E S +
Sbjct: 156 EKRKNPFNSSKLPEGHSSQQTKNEQSKNG-------------RTGLFQTSKEDELSESKE 202
Query: 287 LAAIEGTS-QELTKSHRR---NTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVS 342
+ + TS Q+L KS + ++G+ A + ++L+ ++ + + T S
Sbjct: 203 KSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDS 262
Query: 343 IRSKSVP-GALDKDSLEETEES 363
++++ P G L ++S + +S
Sbjct: 263 LKARGAPRGILKRNSSSSSTDS 284
Score = 41.2 bits (95), Expect = 0.003
Identities = 23/56 (41%), Positives = 36/56 (64%), Gaps = 3/56 (5%)
Query: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNEL---LEAKRRSGKTQQEA 60
I+LSFL + E+E I+ VL+RD LK+ E++R+R L ++ + K SG+ EA
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEA 57
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 263 bits (672), Expect = 4e-70
Identities = 191/605 (31%), Positives = 295/605 (48%), Gaps = 70/605 (11%)
Query: 130 QVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAE-----KSDTSPVAGKKASHDGPKRK 184
+ +VL +D ++ + + EE QS + Q + +S +SP K +H
Sbjct: 355 EFSVLESDRLKNG-MEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSG 413
Query: 185 GFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPG 244
F ++ S E++T + +S+++ P + SS+L E
Sbjct: 414 SFPINGLHS--HSEVLTARP---------------QSMENSPTINEPKDKSSELTRLESV 456
Query: 245 -PRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRR 303
PR+P S+ V P P S+R R+ G E E S L R
Sbjct: 457 LPRSPADELSHCVEPEPSQVPGGSSR------DRQQGSE--------EEPSPVLKTLERS 502
Query: 304 NTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPG-ALDKDSLEETEE 362
PS ++ S S + E +ED K V + + S T+
Sbjct: 503 AARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEKPDQKPVTNECVPRISTVPTQP 562
Query: 363 SIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKTGG 422
+L + + + L S+MSVYS GD+GN++V G I I Y
Sbjct: 563 DNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKE 620
Query: 423 LYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTI 481
L++FV C++LA D KKQR+D YVK+YLLPDK + K+KT + T NP +NE L+Y I
Sbjct: 621 LHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKI 680
Query: 482 SHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDE---WFVLQPKVEFAP- 537
L+T+ L LS+WH D F RNSFLGEVE+ ++W+++N ++ W+ L+ K AP
Sbjct: 681 EKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKT--APV 738
Query: 538 DIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAK 597
+ + +GE+ + L+Y+ PE + G K + + G + +++KE
Sbjct: 739 ALEAENRGEMKLALQYV---------PEPVPGKK-----------LPTTGEVHIWVKECL 778
Query: 598 NLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVC 657
+L ++ G +SFVK +LPD S+ ++ KT + K+ NP +NHT ++ G P+D+ C
Sbjct: 779 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 837
Query: 658 LELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEG 717
+ELT+WD +N FLGG+R+ G+G S+G VDWMDS EE LW+KM N+P T E
Sbjct: 838 VELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEA 896
Query: 718 VLMLR 722
L LR
Sbjct: 897 TLPLR 901
Score = 43.1 bits (100), Expect = 0.001
Identities = 55/262 (20%), Positives = 111/262 (42%), Gaps = 31/262 (11%)
Query: 111 QLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSP 170
QL+ ++G+WF+E KAKR + + G D++R S+ ++ P QS+++ A++S +
Sbjct: 45 QLKNMSGQWFYEAKAKRHRD-KIHGADIIRASMRKKRPQIAAEQSKDR-ENGAKESWVNN 102
Query: 171 VAGKKASHDGPKRKGFLLSKFRSAT----RGEIITPKTDTGRSYSLDLDGQHFRSLKSPP 226
V K + P+ G + A ++ P + +D+ ++ R P
Sbjct: 103 V--NKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSV-----IDMSQENTRKPNVSP 155
Query: 227 GSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMD 286
+ SS L + +T NG RT S+E S +
Sbjct: 156 EKRKNPFNSSKLPEGHSSQQTKNEQSKNG-------------RTGLFQTSKEDELSESKE 202
Query: 287 LAAIEGTS-QELTKSHRR---NTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVS 342
+ + TS Q+L KS + ++G+ A + ++L+ ++ + + T S
Sbjct: 203 KSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDS 262
Query: 343 IRSKSVP-GALDKDSLEETEES 363
++++ P G L ++S + +S
Sbjct: 263 LKARGAPRGILKRNSSSSSTDS 284
Score = 41.2 bits (95), Expect = 0.003
Identities = 23/56 (41%), Positives = 36/56 (64%), Gaps = 3/56 (5%)
Query: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNEL---LEAKRRSGKTQQEA 60
I+LSFL + E+E I+ VL+RD LK+ E++R+R L ++ + K SG+ EA
Sbjct: 2 IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEA 57
>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
Length = 1256
Score = 260 bits (664), Expect = 4e-69
Identities = 157/399 (39%), Positives = 232/399 (58%), Gaps = 42/399 (10%)
Query: 339 DTVSIRSKSVPGALDKDSLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM- 391
D + SKSVP L +S ++ E + S QLS ++ L+S TSL+S+
Sbjct: 876 DKLKRMSKSVPAFLQDES-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVS 934
Query: 392 ---MSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVK 448
MSVYS GD+GN++V G I I Y L++FV C++LA D KKQR+D YVK
Sbjct: 935 GSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 992
Query: 449 SYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFL 507
+YLLPDK + K+KT + T NP +NE L+Y I L+T+ L LS+WH D F RNSFL
Sbjct: 993 AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFL 1052
Query: 508 GEVEIPFDSWNFENPTDE---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLP 563
GEVE+ ++W+++N ++ W+ L+ K AP + + +GE+ + L+Y+
Sbjct: 1053 GEVELDLETWDWDNKQNKQLRWYPLKRKT--APVALEAENRGEMKLALQYV--------- 1101
Query: 564 PEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKA 623
PE + G K + + G + +++KE +L ++ G +SFVK +LPD S+
Sbjct: 1102 PEPVPGKK-----------LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRK 1149
Query: 624 TKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGS 683
++ KT + K+ NP +NHT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+
Sbjct: 1150 SRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGT 1208
Query: 684 GVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLR 722
G S+G VDWMDS EE LW+KM N+P T E L LR
Sbjct: 1209 GKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1247
>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
Length = 1272
Score = 260 bits (664), Expect = 4e-69
Identities = 157/399 (39%), Positives = 232/399 (58%), Gaps = 42/399 (10%)
Query: 339 DTVSIRSKSVPGALDKDSLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM- 391
D + SKSVP L +S ++ E + S QLS ++ L+S TSL+S+
Sbjct: 892 DKLKRMSKSVPAFLQDES-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVS 950
Query: 392 ---MSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVK 448
MSVYS GD+GN++V G I I Y L++FV C++LA D KKQR+D YVK
Sbjct: 951 GSVMSVYS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVK 1008
Query: 449 SYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFL 507
+YLLPDK + K+KT + T NP +NE L+Y I L+T+ L LS+WH D F RNSFL
Sbjct: 1009 AYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFL 1068
Query: 508 GEVEIPFDSWNFENPTDE---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLP 563
GEVE+ ++W+++N ++ W+ L+ K AP + + +GE+ + L+Y+
Sbjct: 1069 GEVELDLETWDWDNKQNKQLRWYPLKRKT--APVALEAENRGEMKLALQYV--------- 1117
Query: 564 PEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKA 623
PE + G K + + G + +++KE +L ++ G +SFVK +LPD S+
Sbjct: 1118 PEPVPGKK-----------LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRK 1165
Query: 624 TKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGS 683
++ KT + K+ NP +NHT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+
Sbjct: 1166 SRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGT 1224
Query: 684 GVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLR 722
G S+G VDWMDS EE LW+KM N+P T E L LR
Sbjct: 1225 GKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 1263
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 259 bits (662), Expect = 6e-69
Identities = 156/393 (39%), Positives = 230/393 (58%), Gaps = 42/393 (10%)
Query: 345 SKSVPGALDKDSLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM----MSV 394
SKSVP L +S ++ E + S QLS ++ L+S TSL+S+ MSV
Sbjct: 2 SKSVPAFLQDES-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSV 60
Query: 395 YSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPD 454
YS GD+GN++V G I I Y L++FV C++LA D KKQR+D YVK+YLLPD
Sbjct: 61 YS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPD 118
Query: 455 KSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIP 513
K + K+KT + T NP +NE L+Y I L+T+ L LS+WH D F RNSFLGEVE+
Sbjct: 119 KGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELD 178
Query: 514 FDSWNFENPTDE---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPPEQLQG 569
++W+++N ++ W+ L+ K AP + + +GE+ + L+Y+ PE + G
Sbjct: 179 LETWDWDNKQNKQLRWYPLKRKT--APVALEAENRGEMKLALQYV---------PEPVPG 227
Query: 570 NKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTL 629
K + + G + +++KE +L ++ G +SFVK +LPD S+ ++ KT
Sbjct: 228 KK-----------LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTR 275
Query: 630 VIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGK 689
+ K+ NP +NHT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+G S+G
Sbjct: 276 AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGT 334
Query: 690 NVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLR 722
VDWMDS EE LW+KM N+P T E L LR
Sbjct: 335 EVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 367
>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
Length = 376
Score = 259 bits (662), Expect = 6e-69
Identities = 156/393 (39%), Positives = 230/393 (58%), Gaps = 42/393 (10%)
Query: 345 SKSVPGALDKDSLEETEESIDALVSSQLS------TNTHRLASGLSTTSLNSM----MSV 394
SKSVP L +S ++ E + S QLS ++ L+S TSL+S+ MSV
Sbjct: 2 SKSVPAFLQDES-DDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSV 60
Query: 395 YSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPD 454
YS GD+GN++V G I I Y L++FV C++LA D KKQR+D YVK+YLLPD
Sbjct: 61 YS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPD 118
Query: 455 KSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIP 513
K + K+KT + T NP +NE L+Y I L+T+ L LS+WH D F RNSFLGEVE+
Sbjct: 119 KGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELD 178
Query: 514 FDSWNFENPTDE---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPPEQLQG 569
++W+++N ++ W+ L+ K AP + + +GE+ + L+Y+ PE + G
Sbjct: 179 LETWDWDNKQNKQLRWYPLKRKT--APVALEAENRGEMKLALQYV---------PEPVPG 227
Query: 570 NKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTL 629
K + + G + +++KE +L ++ G +SFVK +LPD S+ ++ KT
Sbjct: 228 KK-----------LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTR 275
Query: 630 VIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGK 689
+ K+ NP +NHT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+G S+G
Sbjct: 276 AVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGT 334
Query: 690 NVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLR 722
VDWMDS EE LW+KM N+P T E L LR
Sbjct: 335 EVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 367
>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
Length = 365
Score = 254 bits (650), Expect = 2e-67
Identities = 147/379 (38%), Positives = 222/379 (58%), Gaps = 35/379 (9%)
Query: 353 DKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSM----MSVYSETGDYGNVKVSG 408
D+++ +E S + ++ L+S TSL+S+ MSVYS GD+GN++V G
Sbjct: 4 DRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYS--GDFGNLEVKG 61
Query: 409 EILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTG 468
I I Y L++FV C++LA D KKQR+D YVK+YLLPDK + K+KT +
Sbjct: 62 NIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKK 121
Query: 469 T-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDE-- 525
T NP +NE L+Y I L+T+ L LS+WH D F RNSFLGEVE+ ++W+++N ++
Sbjct: 122 TLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQL 181
Query: 526 -WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPV 583
W+ L+ K AP + + +GE+ + L+Y+ PE + G K +
Sbjct: 182 RWYPLKRKT--APVALEAENRGEMKLALQYV---------PEPVPGKK-----------L 219
Query: 584 ISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTF 643
+ G + +++KE +L ++ G +SFVK +LPD S+ ++ KT + K+ NP +NHT
Sbjct: 220 PTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTM 278
Query: 644 MFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRL 703
++ G P+D+ C+ELT+WD +N FLGG+R+ G+G S+G VDWMDS EE L
Sbjct: 279 VYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVAL 337
Query: 704 WQKMANNPGTPFEGVLMLR 722
W+KM N+P T E L LR
Sbjct: 338 WEKMVNSPNTWIEATLPLR 356
>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
Length = 336
Score = 251 bits (641), Expect = 2e-66
Identities = 139/338 (41%), Positives = 205/338 (60%), Gaps = 31/338 (9%)
Query: 390 SMMSVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKS 449
S+MSVYS GD+GN++V G I I Y L++FV C++LA D KKQR+D YVK+
Sbjct: 16 SVMSVYS--GDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKA 73
Query: 450 YLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLG 508
YLLPDK + K+KT + T NP +NE L+Y I L+T+ L LS+WH D F RNSFLG
Sbjct: 74 YLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLG 133
Query: 509 EVEIPFDSWNFENPTDE---WFVLQPKVEFAP-DIGLQYKGELTVVLRYIPPEENLMLPP 564
EVE+ ++W+++N ++ W+ L+ K AP + + +GE+ + L+Y+ P
Sbjct: 134 EVELDLETWDWDNKQNKQLRWYPLKRKT--APVALEAENRGEMKLALQYV---------P 182
Query: 565 EQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKAT 624
E + G K + + G + +++KE +L ++ G +SFVK +LPD S+ +
Sbjct: 183 EPVPGKK-----------LPTTGEVHIWVKECLDLPLLR-GSHLNSFVKCTILPDTSRKS 230
Query: 625 KHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSG 684
+ KT + K+ NP +NHT ++ G P+D+ C+ELT+WD +N FLGG+R+ G+G
Sbjct: 231 RQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTG 289
Query: 685 VSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLR 722
S+G VDWMDS EE LW+KM N+P T E L LR
Sbjct: 290 KSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLR 327
>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
Length = 550
Score = 234 bits (597), Expect = 2e-61
Identities = 139/353 (39%), Positives = 211/353 (59%), Gaps = 36/353 (10%)
Query: 379 LASGLSTTSLNSMM---SVYSETGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAI 435
L+S S +SLNS S S +GD V+V G + + Y L + V C+ LA
Sbjct: 224 LSSSSSVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAA 283
Query: 436 GDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT-GTNPEFNETLKYTISHTQLETRTLQLS 494
+++R+D YVKSYLLPDK +KRKT ++ NP FNETL+Y++ +L+ R L LS
Sbjct: 284 A--RRRRSDPYVKSYLLPDKQ--SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLS 339
Query: 495 VWHYDRFGRNSFLGEVEIPFDSWNF-ENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRY 553
VWH + GRN FLGEVE+P D+W++ PT W LQP+V +PD L +G L + L+Y
Sbjct: 340 VWHRESLGRNIFLGEVEVPLDTWDWGSEPT--WLPLQPRVPPSPD-DLPSRGLLALSLKY 396
Query: 554 IPP-EENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFV 612
+P E LPP G L ++KEA++L +++ G+ D++V
Sbjct: 397 VPAGSEGAGLPP---------------------SGELHFWVKEARDLLPLRA-GSLDTYV 434
Query: 613 KGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNI 672
+ ++LPDDS+A++ +T V+++S++P +NHT ++ G P D++ C EL++WD A +N
Sbjct: 435 QCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGAL-ANR 493
Query: 673 FLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLMLRSSM 725
LGG RL+ G+G S+G V WMDS EE++LWQ + P +G+L LR+++
Sbjct: 494 QLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPLRTNL 546
Score = 39.7 bits (91), Expect = 0.010
Identities = 40/182 (21%), Positives = 81/182 (44%), Gaps = 21/182 (11%)
Query: 86 LRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILR 145
LR E RV+ + +V D QL+I+TG+WF E +++R + G+D+VR S+ R
Sbjct: 55 LRQLEEGRVS----KLRASVADP-GQLKILTGDWFQEARSQRHHNAH-FGSDLVRASMRR 108
Query: 146 -RSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKT 204
+S ++ ++ + A K + + P+ + L + ++ E +
Sbjct: 109 KKSTRGDQAPGHDREAEAAVKEKEEGPEPRLTIDEAPQER---LRETEASDPEEASQAQE 165
Query: 205 DTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPGTQSSP 264
D G+ Q + ++ P + S G +QEP P+ ++ ++ + + +P
Sbjct: 166 DPGQG------DQQVCAEEADPELEPASGG-----EQEPRPQQAQTKAASQILENGEEAP 214
Query: 265 AP 266
P
Sbjct: 215 GP 216
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/36 (47%), Positives = 28/36 (77%)
Query: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLK 43
++LSFL + E+E I GVL+RD L+++E+ R+ KL+
Sbjct: 32 LDLSFLTEEEQEAIAGVLQRDARLRQLEEGRVSKLR 67
>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
Length = 542
Score = 221 bits (563), Expect = 2e-57
Identities = 144/387 (37%), Positives = 209/387 (54%), Gaps = 26/387 (6%)
Query: 344 RSKSVPGALDKDSLEETEESIDALVSSQLSTNTHR----LASGLSTTSLNSMMSVYSETG 399
R S P L + E+ + S + ++ Q ++ + G SL S+ S +E G
Sbjct: 172 RKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMG 231
Query: 400 DYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNN 459
++ N V+GEI I YC+KT L I +K C+NLA G+EKK++ + YVK+YLLPD+S
Sbjct: 232 NFDNANVTGEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQG 291
Query: 460 KRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWN 518
KRKT ++ T +P F ETLKY ++ QL TR LQ+SVWH R FLGEV IP +W+
Sbjct: 292 KRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWD 351
Query: 519 FENPTDE---WFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKK 575
FE+ T + W L+ K E D Q GELTV + + P P +LQ +
Sbjct: 352 FEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVLPSR-----PRKLQ-----EA 401
Query: 576 GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 635
+ + P + G + V + AKNL V+ GT +SFVKG L D + + K+ V++K
Sbjct: 402 QEGTDQPSLHGQLCLV-VLGAKNL-PVRPDGTLNSFVKGCLTLPDQQKLRLKSPVLRKQA 459
Query: 636 NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSN-IFLGGVRLNSGSGVSHGKNVDWM 694
PQW H+F+FSG+ P ++ LELT+WD+ F N LGG RL S + G
Sbjct: 460 CPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGG----- 514
Query: 695 DSQGEEQRLWQKMANNPGTPFEGVLML 721
D+ + WQK+ ++P + L+L
Sbjct: 515 DACSLSKLQWQKVLSSPNLWTDMTLVL 541
Score = 102 bits (254), Expect = 1e-21
Identities = 72/237 (30%), Positives = 110/237 (46%), Gaps = 27/237 (11%)
Query: 8 INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQ--QEASRVCV 65
I+LS L + E+E IL VL RD+ ++ E++R RKLK L + + K + + C
Sbjct: 5 IDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEHKEKCCA 64
Query: 66 HCHRNLGLIFDRGDPCQACSLRVCRECRV-AGPNGSWKCTVCDKIAQLRIITGEWFFEEK 124
C + LG + RG C+ CS RVC +CRV +WKCTVC + ++I TGEWF+EE+
Sbjct: 65 RCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEER 124
Query: 125 AKRF----KQVNVLG------------------TDVVRQSILRRSPGAEEVQSQ--EQTR 160
AK+F K V G V +S RSPG + +
Sbjct: 125 AKKFPTGGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRKVSAPDILKPLN 184
Query: 161 QDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQ 217
Q+ K T+P+ ++ P FR + I + T+ G + ++ G+
Sbjct: 185 QEDPKCSTNPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGE 241
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 129 bits (323), Expect = 1e-29
Identities = 91/307 (29%), Positives = 136/307 (44%), Gaps = 49/307 (15%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G + + Y +++G L + + LA D +D YV+ YLLPDK R + K +T
Sbjct: 110 GRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGS-SDPYVRVYLLPDKRRRYETKVHRQT 168
Query: 468 GTNPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWF 527
NP F ET + + + +L R L ++V+ +DRF RN +GEV +P S + P W
Sbjct: 169 -LNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWR 227
Query: 528 VLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGG 587
LQ AP + G++ LRY+P + G
Sbjct: 228 ELQA----APREEQEKLGDICFSLRYVP-----------------------------TAG 254
Query: 588 ILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSG 647
L V + EAKNL + GG SD +VK +LL K K KT + K ++NP +N F F
Sbjct: 255 KLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFE- 313
Query: 648 IHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKM 707
+ ++ V +ELT+ D + N +G V + + +G G R W M
Sbjct: 314 VPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAG-------------GAGLRHWADM 360
Query: 708 ANNPGTP 714
NP P
Sbjct: 361 LANPRRP 367
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 124 bits (310), Expect = 4e-28
Identities = 89/308 (28%), Positives = 146/308 (47%), Gaps = 51/308 (16%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G++ + Y ++ L + V L D +D YVK +LLPDK + K +TK+
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALD-MGGTSDPYVKVFLLPDKKK--KYETKVHR 197
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEW 526
T NP FNET + + + +L +TL ++++ +DRF ++ +GEV++P ++ + P +EW
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
Query: 527 FVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISG 586
LQ + P + G++ LRY+P +
Sbjct: 258 RDLQGGEKEEP----EKLGDICTSLRYVP-----------------------------TA 284
Query: 587 GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFS 646
G L V I EAKNL + GG SD +VK +L+ + + K KT V KK++NP +N +F F
Sbjct: 285 GKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE 344
Query: 647 GIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 706
I + I+ V + +T+ D + N +G + + S ++ G E R W
Sbjct: 345 -IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGS-------------NATGTELRHWSD 390
Query: 707 MANNPGTP 714
M NP P
Sbjct: 391 MLANPRRP 398
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 124 bits (310), Expect = 4e-28
Identities = 89/308 (28%), Positives = 146/308 (47%), Gaps = 51/308 (16%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G++ + Y ++ L + V L D +D YVK +LLPDK + K +TK+
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALD-MGGTSDPYVKVFLLPDKKK--KYETKVHR 197
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEW 526
T NP FNET + + + +L +TL ++++ +DRF ++ +GEV++P ++ + P +EW
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
Query: 527 FVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISG 586
LQ + P + G++ LRY+P +
Sbjct: 258 RDLQGGEKEEP----EKLGDICTSLRYVP-----------------------------TA 284
Query: 587 GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFS 646
G L V I EAKNL + GG SD +VK +L+ + + K KT V KK++NP +N +F F
Sbjct: 285 GKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE 344
Query: 647 GIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 706
I + I+ V + +T+ D + N +G + + S ++ G E R W
Sbjct: 345 -IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGS-------------NATGTELRHWSD 390
Query: 707 MANNPGTP 714
M NP P
Sbjct: 391 MLANPRRP 398
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 117 bits (294), Expect = 3e-26
Identities = 81/241 (33%), Positives = 120/241 (49%), Gaps = 36/241 (14%)
Query: 444 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
D YVK +LLP S+ NK +TK +R NP +NETL Y I+ + +TL++SV D+F
Sbjct: 163 DPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKF 222
Query: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPK---VEFAPDIGLQYKGELTVVLRYIPPEE 558
N F+GE +P N T + + K V+ D L+ +G + + L+Y ++
Sbjct: 223 RHNEFIGETRVPLKKLK-PNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQ 281
Query: 559 NLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
L+ V I +L A+ + G SD +VK YL P
Sbjct: 282 GLL-----------------------------VGIVRCAHLAAMDANGYSDPYVKTYLRP 312
Query: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
D K +KHKT V KK++NP++N F + I D+ LE+T+WD + SN F+GGV
Sbjct: 313 DVDKKSKHKTAVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDYDIGKSNDFIGGVV 371
Query: 679 L 679
L
Sbjct: 372 L 372
Score = 76.6 bits (187), Expect = 7e-14
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 2/104 (1%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G IL+ + Y + GL + + C +LA D +D YVK+YL PD + +K KT ++
Sbjct: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY-SDPYVKTYLRPDVDKKSKHKTAVKK 326
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEV 510
T NPEFNE Y I H L ++L+++VW YD N F+G V
Sbjct: 327 KTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGV 370
Score = 65.9 bits (159), Expect = 1e-10
Identities = 32/91 (35%), Positives = 52/91 (57%)
Query: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
L I +AK L + G +D +VK +LLP SKA K +T ++ ++NP WN T + GI
Sbjct: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
Query: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
+D+ L +++ D++ F N F+G R+
Sbjct: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 116 bits (291), Expect = 6e-26
Identities = 86/308 (27%), Positives = 144/308 (46%), Gaps = 51/308 (16%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G++ + Y ++ L + + L D +D YVK +LLPDK + K +TK+
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKK--KFETKVHR 200
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEW 526
T NP FNE + + +++L +TL ++V+ +DRF ++ +GE ++P ++ +F + T+EW
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260
Query: 527 FVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISG 586
LQ A + G++ LRY+P +
Sbjct: 261 RDLQS----AEKEEQEKLGDICFSLRYVP-----------------------------TA 287
Query: 587 GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFS 646
G L V I EAKNL + GG SD +VK +L+ + + K KT + K ++NP +N +F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 647 GIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 706
+ + I+ V + +T+ D + N +G V + +S G E R W
Sbjct: 348 -VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSD 393
Query: 707 MANNPGTP 714
M NP P
Sbjct: 394 MLANPRRP 401
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 116 bits (291), Expect = 6e-26
Identities = 86/308 (27%), Positives = 144/308 (46%), Gaps = 51/308 (16%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G++ + Y ++ L + + L D +D YVK +LLPDK + K +TK+
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKK--KFETKVHR 200
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEW 526
T NP FNE + + +++L +TL ++V+ +DRF ++ +GE ++P ++ +F + T+EW
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260
Query: 527 FVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISG 586
LQ A + G++ LRY+P +
Sbjct: 261 RDLQS----AEKEEQEKLGDICFSLRYVP-----------------------------TA 287
Query: 587 GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFS 646
G L V I EAKNL + GG SD +VK +L+ + + K KT + K ++NP +N +F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 647 GIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 706
+ + I+ V + +T+ D + N +G V + +S G E R W
Sbjct: 348 -VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSD 393
Query: 707 MANNPGTP 714
M NP P
Sbjct: 394 MLANPRRP 401
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 116 bits (291), Expect = 6e-26
Identities = 86/308 (27%), Positives = 144/308 (46%), Gaps = 51/308 (16%)
Query: 408 GEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRT 467
G++ + Y ++ L + + L D +D YVK +LLPDK + K +TK+
Sbjct: 144 GKLQYSLDYDFQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKK--KFETKVHR 200
Query: 468 GT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEW 526
T NP FNE + + +++L +TL ++V+ +DRF ++ +GE ++P ++ +F + T+EW
Sbjct: 201 KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260
Query: 527 FVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISG 586
LQ A + G++ LRY+P +
Sbjct: 261 RDLQS----AEKEEQEKLGDICFSLRYVP-----------------------------TA 287
Query: 587 GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFS 646
G L V I EAKNL + GG SD +VK +L+ + + K KT + K ++NP +N +F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 647 GIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 706
+ + I+ V + +T+ D + N +G V + +S G E R W
Sbjct: 348 -VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVG-------------YNSTGAELRHWSD 393
Query: 707 MANNPGTP 714
M NP P
Sbjct: 394 MLANPRRP 401
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 112 bits (281), Expect = 9e-25
Identities = 98/355 (27%), Positives = 155/355 (43%), Gaps = 48/355 (13%)
Query: 342 SIRSKSVPGALDKDSLEETEESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDY 401
++ + VPG D + E S +S + L S + S S E
Sbjct: 79 AVNTAPVPGQTPHDESDRRTEP-----RSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSR 133
Query: 402 GNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKR 461
N+ G I + Y ++ L + + + L D +D +VK YLLPDK +
Sbjct: 134 ENL---GRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGT-SDPFVKIYLLPDKKHKLET 189
Query: 462 KTKIRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFE 520
K K R NP +NET + + ++ R L L V YDRF RN +GEV IP + +
Sbjct: 190 KVK-RKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLT 248
Query: 521 NPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKE 580
W L+P + G +GEL + L Y P +++
Sbjct: 249 QMQTFWKDLKPCSD-----GSGSRGELLLSLCYNPSANSII------------------- 284
Query: 581 SPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWN 640
V I +A+NL A+ GGTSD +VK +L+ D + K KT+ +K+++NP +N
Sbjct: 285 ----------VNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFN 334
Query: 641 HTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMD 695
+F F I + ++ + +T+ DK+ S N +G + L+ SG K+ W D
Sbjct: 335 ESFAFD-IPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKH--WKD 386
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 108 bits (271), Expect = 1e-23
Identities = 87/278 (31%), Positives = 129/278 (46%), Gaps = 27/278 (9%)
Query: 444 DAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
D YVK +LLP + NK KTK + T NP +NE L Y+ I+ + + L+++V D+
Sbjct: 126 DPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL 185
Query: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 561
N F+GE+ +P L+ +V A ++ LR I +
Sbjct: 186 SHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASP------SSMSAALRGISCYLKEL 239
Query: 562 LPPEQLQGNKTFKKGKKKESPVISG---GILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
EQ QG ++G+ S S G+L V I +L A+ G SD +VK YL P
Sbjct: 240 EQAEQGQGLLE-ERGRILLSLSYSSRRRGLL-VGILRCAHLAAMDVNGYSDPYVKTYLRP 297
Query: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
D K +KHKT V KK++NP++N F + I + LE+T+WD + SN F+GGV
Sbjct: 298 DVDKKSKHKTCVKKKTLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGGVS 356
Query: 679 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 716
L G ++GE ++ W P E
Sbjct: 357 LGPG-------------ARGEARKHWSDCLQQPDAALE 381
Score = 80.1 bits (196), Expect = 7e-15
Identities = 45/112 (40%), Positives = 65/112 (58%), Gaps = 2/112 (1%)
Query: 402 GNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKR 461
G ++ G ILL +SY + GL + + C +LA D +D YVK+YL PD + +K
Sbjct: 247 GLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGY-SDPYVKTYLRPDVDKKSKH 305
Query: 462 KTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEI 512
KT ++ T NPEFNE Y I + L T+TL+++VW YD N F+G V +
Sbjct: 306 KTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
Score = 63.5 bits (153), Expect = 6e-10
Identities = 33/91 (36%), Positives = 49/91 (53%)
Query: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
L I AK L + G +D +VK +LLP KA K KT + ++NP WN +SGI
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
Query: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
DI + L + + D++ S N F+G +R+
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRV 196
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 108 bits (269), Expect = 2e-23
Identities = 89/322 (27%), Positives = 137/322 (42%), Gaps = 53/322 (16%)
Query: 398 TGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSR 457
+G+ G G I + Y Y + L + + +L D +D YVK YLLPD R
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGF-SDPYVKIYLLPD--R 347
Query: 458 NNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDS 516
K +TK+ T NP FNET ++++ +L R L SV+ +DRF R+ +G+V +
Sbjct: 348 KKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLL 407
Query: 517 WNFENPTDE--WFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFK 574
E P D W + D+ GEL L Y+P
Sbjct: 408 ELAEQPPDRPLWRDIVEGGSEKADL-----GELNFSLCYLP------------------- 443
Query: 575 KGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKS 634
+ G L V I +A NL A+ G SD +VK L+ + + K KT + K +
Sbjct: 444 ----------TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 635 VNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWM 694
+NP +N +F + P+ ++NV L + + D + N +G R+ + HG+
Sbjct: 494 LNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGR----- 547
Query: 695 DSQGEEQRLWQKMANNPGTPFE 716
W +M NP P E
Sbjct: 548 -------EHWAEMLANPRKPVE 562
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 108 bits (269), Expect = 2e-23
Identities = 89/322 (27%), Positives = 137/322 (42%), Gaps = 53/322 (16%)
Query: 398 TGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSR 457
+G+ G G I + Y Y + L + + +L D +D YVK YLLPD R
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGF-SDPYVKIYLLPD--R 347
Query: 458 NNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDS 516
K +TK+ T NP FNET ++++ +L R L SV+ +DRF R+ +G+V +
Sbjct: 348 KKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLL 407
Query: 517 WNFENPTDE--WFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFK 574
E P D W + D+ GEL L Y+P
Sbjct: 408 ELAEQPPDRPLWRDIVEGGSEKADL-----GELNFSLCYLP------------------- 443
Query: 575 KGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKS 634
+ G L V I +A NL A+ G SD +VK L+ + + K KT + K +
Sbjct: 444 ----------TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 635 VNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWM 694
+NP +N +F + P+ ++NV L + + D + N +G R+ + HG+
Sbjct: 494 LNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGR----- 547
Query: 695 DSQGEEQRLWQKMANNPGTPFE 716
W +M NP P E
Sbjct: 548 -------EHWAEMLANPRKPVE 562
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 108 bits (269), Expect = 2e-23
Identities = 89/322 (27%), Positives = 137/322 (42%), Gaps = 53/322 (16%)
Query: 398 TGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSR 457
+G+ G G I + Y Y + L + + +L D +D YVK YLLPD R
Sbjct: 291 SGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGF-SDPYVKIYLLPD--R 347
Query: 458 NNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDS 516
K +TK+ T NP FNET ++++ +L R L SV+ +DRF R+ +G+V +
Sbjct: 348 KKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLL 407
Query: 517 WNFENPTDE--WFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFK 574
E P D W + D+ GEL L Y+P
Sbjct: 408 ELAEQPPDRPLWRDIVEGGSEKADL-----GELNFSLCYLP------------------- 443
Query: 575 KGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKS 634
+ G L V I +A NL A+ G SD +VK L+ + + K KT + K +
Sbjct: 444 ----------TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 635 VNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWM 694
+NP +N +F + P+ ++NV L + + D + N +G R+ + HG+
Sbjct: 494 LNPTYNEALVFD-VAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGR----- 547
Query: 695 DSQGEEQRLWQKMANNPGTPFE 716
W +M NP P E
Sbjct: 548 -------EHWAEMLANPRKPVE 562
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 105 bits (262), Expect = 1e-22
Identities = 86/278 (30%), Positives = 136/278 (48%), Gaps = 31/278 (11%)
Query: 444 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
D YVK +LLP S++NK +TK +R NP +NETL Y I+ ++ +TL++SV D+F
Sbjct: 429 DPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF 488
Query: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 561
G N F+GE N + + +V I ++ G EE +
Sbjct: 489 GHNEFIGETRFSLKKLK-PNQRKNFNICLERV-----IPMKRAGTTGSARGMALYEEEQV 542
Query: 562 LPPEQLQGNKTFKKGKKKESPVIS---GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
++ ++GK S + S GG++ V I +L A+ + G SD FVK +L P
Sbjct: 543 ERVGDIE-----ERGKILVSLMYSTQQGGLI-VGIIRCVHLAAMDANGYSDPFVKLWLKP 596
Query: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
D K KHKT + KK++NP++N F F I D+ L++++WD + SN ++GG +
Sbjct: 597 DMGKKAKHKTQIKKKTLNPEFNEEF-FYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQ 655
Query: 679 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 716
L G+S ++GE + W + N E
Sbjct: 656 L----GIS---------AKGERLKHWYECLKNKDKKIE 680
Score = 78.6 bits (192), Expect = 2e-14
Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 4/131 (3%)
Query: 385 TTSLNSMMSVYSE--TGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQR 442
TT M++Y E G+++ G+IL+ + Y + GGL + + C +LA D
Sbjct: 527 TTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGY- 585
Query: 443 TDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRF 501
+D +VK +L PD + K KT+I+ T NPEFNE Y I H+ L ++L +SVW YD
Sbjct: 586 SDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIG 645
Query: 502 GRNSFLGEVEI 512
N ++G ++
Sbjct: 646 KSNDYIGGCQL 656
Score = 67.4 bits (163), Expect = 4e-11
Identities = 32/92 (34%), Positives = 55/92 (59%)
Query: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
L+ I +AK L + S G +D +VK +LLP SK+ K +T ++ + NP WN T ++ GI
Sbjct: 409 LQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGI 468
Query: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRLN 680
+D++ L +++ D++ F N F+G R +
Sbjct: 469 TDEDMQRKTLRISVCDEDKFGHNEFIGETRFS 500
Score = 63.2 bits (152), Expect = 8e-10
Identities = 66/275 (24%), Positives = 109/275 (39%), Gaps = 33/275 (12%)
Query: 13 LLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLG 72
L D EKE+I V+ R E ++++E +RI +L + L ++ + C+ C LG
Sbjct: 50 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRK---NVAGDGVNRCILCGEQLG 106
Query: 73 LIFDRGDPCQACSLRVCRECRVAGPN---GSWKCTVCDKIAQLRIITGEWFFEEKAKRFK 129
++ C+ C VC +C V N W C +C + ++ +G WFF+ K+
Sbjct: 107 MLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQ-- 164
Query: 130 QVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRK----- 184
VL + + + P E + EQ + + +P G GP +K
Sbjct: 165 ---VLPQPMPIKKTKPQQP-VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDP 220
Query: 185 ------GFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDL 238
G R A+ + + D S S D G S +SP G R ++ +
Sbjct: 221 ASAPGRGNYGPPVRRASEARMSSSSRD---SESWDHSGGAGDSSRSPAGLRRANSVQASR 277
Query: 239 ----NDQEPGPRTPKSSRSNGVTPGTQSSPAPSTR 269
+ Q P P P G G++ P P+ R
Sbjct: 278 PAPGSVQSPAPPQPGQP---GTPGGSRPGPGPAGR 309
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 105 bits (262), Expect = 1e-22
Identities = 86/278 (30%), Positives = 136/278 (48%), Gaps = 31/278 (11%)
Query: 444 DAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRF 501
D YVK +LLP S++NK +TK +R NP +NETL Y I+ ++ +TL++SV D+F
Sbjct: 425 DPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF 484
Query: 502 GRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEENLM 561
G N F+GE N + + +V I ++ G EE +
Sbjct: 485 GHNEFIGETRFSLKKLK-PNQRKNFNICLERV-----IPMKRAGTTGSARGMALYEEEQV 538
Query: 562 LPPEQLQGNKTFKKGKKKESPVIS---GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLP 618
++ ++GK S + S GG++ V I +L A+ + G SD FVK +L P
Sbjct: 539 ERVGDIE-----ERGKILVSLMYSTQQGGLI-VGIIRCVHLAAMDANGYSDPFVKLWLKP 592
Query: 619 DDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVR 678
D K KHKT + KK++NP++N F F I D+ L++++WD + SN ++GG +
Sbjct: 593 DMGKKAKHKTQIKKKTLNPEFNEEF-FYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQ 651
Query: 679 LNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFE 716
L G+S ++GE + W + N E
Sbjct: 652 L----GIS---------AKGERLKHWYECLKNKDKKIE 676
Score = 78.6 bits (192), Expect = 2e-14
Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 4/131 (3%)
Query: 385 TTSLNSMMSVYSE--TGDYGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQR 442
TT M++Y E G+++ G+IL+ + Y + GGL + + C +LA D
Sbjct: 523 TTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGY- 581
Query: 443 TDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRF 501
+D +VK +L PD + K KT+I+ T NPEFNE Y I H+ L ++L +SVW YD
Sbjct: 582 SDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIG 641
Query: 502 GRNSFLGEVEI 512
N ++G ++
Sbjct: 642 KSNDYIGGCQL 652
Score = 67.4 bits (163), Expect = 4e-11
Identities = 32/92 (34%), Positives = 55/92 (59%)
Query: 589 LEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGI 648
L+ I +AK L + S G +D +VK +LLP SK+ K +T ++ + NP WN T ++ GI
Sbjct: 405 LQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGI 464
Query: 649 HPQDIKNVCLELTIWDKEAFSSNIFLGGVRLN 680
+D++ L +++ D++ F N F+G R +
Sbjct: 465 TDEDMQRKTLRISVCDEDKFGHNEFIGETRFS 496
Score = 63.2 bits (152), Expect = 8e-10
Identities = 66/275 (24%), Positives = 109/275 (39%), Gaps = 33/275 (12%)
Query: 13 LLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRVCVHCHRNLG 72
L D EKE+I V+ R E ++++E +RI +L + L ++ + C+ C LG
Sbjct: 46 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRK---NVAGDGVNRCILCGEQLG 102
Query: 73 LIFDRGDPCQACSLRVCRECRVAGPN---GSWKCTVCDKIAQLRIITGEWFFEEKAKRFK 129
++ C+ C VC +C V N W C +C + ++ +G WFF+ K+
Sbjct: 103 MLGSACVVCEDCKKNVCTKCGVETNNRLHSVWLCKICIEQREVWKRSGAWFFKGFPKQ-- 160
Query: 130 QVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDGPKRK----- 184
VL + + + P E + EQ + + +P G GP +K
Sbjct: 161 ---VLPQPMPIKKTKPQQP-VSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPDP 216
Query: 185 ------GFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDL 238
G R A+ + + D S S D G S +SP G R ++ +
Sbjct: 217 ASAPGRGNYGPPVRRASEARMSSSSRD---SESWDHSGGAGDSSRSPAGLRRANSVQASR 273
Query: 239 ----NDQEPGPRTPKSSRSNGVTPGTQSSPAPSTR 269
+ Q P P P G G++ P P+ R
Sbjct: 274 PAPGSVQSPAPPQPGQP---GTPGGSRPGPGPAGR 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,958,719
Number of Sequences: 37866
Number of extensions: 1402545
Number of successful extensions: 5941
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 5063
Number of HSP's gapped (non-prelim): 887
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.