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Search of human proteins with 253970456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
(755 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 1538 0.0
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 1538 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 122 2e-27
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 87 4e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 87 4e-17
gi|217330641 IWS1 homolog [Homo sapiens] 87 6e-17
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 87 7e-17
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 86 2e-16
gi|24415404 MDN1, midasin homolog [Homo sapiens] 79 2e-14
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 79 2e-14
gi|16445033 ACRC protein [Homo sapiens] 78 3e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 77 8e-14
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 77 8e-14
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 77 8e-14
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 76 1e-13
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 76 1e-13
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 76 1e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 76 1e-13
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 75 3e-13
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 75 3e-13
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 74 7e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 74 7e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 73 9e-13
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 73 9e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 73 1e-12
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 1e-12
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 1e-12
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 72 1e-12
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 72 2e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 71 3e-12
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 1538 bits (3981), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF 60
MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF
Sbjct: 1 MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF 60
Query: 61 PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA 120
PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA
Sbjct: 61 PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA 120
Query: 121 ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL 180
ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL
Sbjct: 121 ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL 180
Query: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL
Sbjct: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
Query: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ
Sbjct: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
Query: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR
Sbjct: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
Query: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM 420
EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM
Sbjct: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM 420
Query: 421 AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC 480
AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC 480
Query: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540
SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE
Sbjct: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540
Query: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS
Sbjct: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
Query: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660
EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD
Sbjct: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660
Query: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI 755
SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI 755
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 1538 bits (3981), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF 60
MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF
Sbjct: 1 MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWF 60
Query: 61 PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA 120
PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA
Sbjct: 61 PKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKA 120
Query: 121 ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL 180
ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL
Sbjct: 121 ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNL 180
Query: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL
Sbjct: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
Query: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ
Sbjct: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
Query: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR
Sbjct: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
Query: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM 420
EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM
Sbjct: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGM 420
Query: 421 AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC 480
AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSC 480
Query: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540
SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE
Sbjct: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540
Query: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS
Sbjct: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
Query: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660
EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD
Sbjct: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660
Query: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI 755
SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI 755
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 122 bits (305), Expect = 2e-27
Identities = 106/361 (29%), Positives = 158/361 (43%), Gaps = 26/361 (7%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
EE RE EE G E G ER R E + +E
Sbjct: 741 EEGDREEEEEKEG-----EGKEEGEG-----EEVEGEREKEEGERKKEERAGKEEKGEEE 790
Query: 416 TATGMAFEEPIDEKKFEKTE----DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC 471
G EE + + EK E +GGE EEG E +E E E EEG E+E EG
Sbjct: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE 850
Query: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESE------DDL 525
+ G EG ++E EEG EE + E ++ + + E G +E E ++
Sbjct: 851 EEEG-EGK-GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG 908
Query: 526 NKESEEEVGPTKESEE-DDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH 584
E EEE G K EE ++ E E +E+ E + EDG EE G + +EEG +
Sbjct: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
Query: 585 ENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDE 644
E + E E + E E E +G E+ +EEG E E+ E E EE+ +V + E
Sbjct: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
Query: 645 KEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNE 704
+ + E +E+G E +++ +EG+ +E + +E+E+ +GK E +E+ D
Sbjct: 1029 EGEGEGEEEEGEEEGEEREKEGEGEE---NRRNREEEEEEEGKYQETGEEENERQDGEEY 1085
Query: 705 K 705
K
Sbjct: 1086 K 1086
Score = 114 bits (285), Expect = 3e-25
Identities = 113/419 (26%), Positives = 187/419 (44%), Gaps = 47/419 (11%)
Query: 349 GTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPST 408
G +Q EE RE+ E+ +G E + L + +R G + + E
Sbjct: 665 GAEHWQDEE--REKGEKDKGRGEMERPGEGEKELAEKEEWK--KRDGEEQEQKEREQGHQ 720
Query: 409 SKMNAQ-----ETATGMAFEEPIDEKKFEKTE----DGGEFEEGASENNAKESSPEKEAE 459
+ N + E G EE D ++ E+ E + GE EE E +E +KE
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780
Query: 460 EGCPEKESEEGCPKRGFEGSCSQK--ESEEGNPVRGSEEDSPKKESKKKTLKNDCEEN-- 515
G EK EEG G E + E EEG V G E + K E +++ + + EE
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
Query: 516 --------GLAKESEDDLNKESEEEVGPTK------ESEEDDSEKESDEDCSEKQSEDGS 561
G +E E +E EE G + E EE++ E E +E+ + E+
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 562 EREFEENGLEKDLDEEG---SEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSER 618
E E EE G + +EEG E+E E + E EE + E + E +G E+ + EG E
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE 960
Query: 619 EFDEDSDE------KEEEEDTYEKVFDDESDEKEDEEYADEKGL-----EAADKKAEEGD 667
E + + +E +E E + E+ + E +E+E EE +E+G E ++ EEG+
Sbjct: 961 EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020
Query: 668 ADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDS--NEKLFDEEEDSSEKLFDDSDER 724
+ ++ E + E E+ +G+E + EK E +++ N + +EEE ++ ++ +ER
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079
Score = 111 bits (278), Expect = 2e-24
Identities = 95/330 (28%), Positives = 162/330 (49%), Gaps = 19/330 (5%)
Query: 414 QETATGMAFEEPIDEKKFEKTEDGGEFE---EGASENNAKESSPEKEAEEGCPEKESEEG 470
+E ++G + + +K EK + GE E EG E KE +++ EE +KE E+G
Sbjct: 660 EEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ-EQKEREQG 718
Query: 471 CPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESE 530
K E + +E E G EE+ ++E ++K + + +E G +E E + KE
Sbjct: 719 HQK---ERNQEMEEGGEEEHGEGEEEEGDREEEEEK--EGEGKEEGEGEEVEGEREKEEG 773
Query: 531 EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENG-LEKDLDEEGS---EKELHEN 586
E + +E+ E+E D+ E++ +G E EE G +E EEG E+E E
Sbjct: 774 ERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG 833
Query: 587 VLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKE 646
++E E + E E E++ E +EEG E E +E+ +E E E + E+ + E +E+
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE--EEEGEGEGEEEG 891
Query: 647 DEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKL 706
+ E +E+G E ++ EG+ +E+ E ++E E+ +G+ E+ E ED +
Sbjct: 892 EGEGEEEEG-EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEG-- 948
Query: 707 FDEEEDSSEKLFDDSDERGTLGGFGSVEEG 736
+EEE E ++ + G G G EEG
Sbjct: 949 -EEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
Score = 111 bits (277), Expect = 3e-24
Identities = 93/302 (30%), Positives = 146/302 (48%), Gaps = 18/302 (5%)
Query: 427 DEKKFEKTEDGGEFEEGA---SENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQK 483
+E + E+ E E EEG E KE E+E ++G E+E EG RG +
Sbjct: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG---RG-------E 806
Query: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDD 543
E EEG V G E + K E +++ + + EE E E+ +E E E +E EE +
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Query: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFE 603
E+E +E E + E+G E E EE G + +EEG + E + E EE + + E
Sbjct: 867 GEEEGEEGEGEGEEEEG-EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
Query: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663
++G + +EEG E E ++ E EEEE +E ++E E E EE + +G E +
Sbjct: 926 EEGEGEGEEEEG-EGEGEDGEGEGEEEEGEWEG--EEEEGEGEGEEEGEGEGEEGEGEGE 982
Query: 664 EEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
EE E EE +++ +E+ +G+E E E E++ E + EE E ++ +E
Sbjct: 983 EEEGEGEGEEEEGEEEGEEEGEGEE-EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 724 RG 725
G
Sbjct: 1042 EG 1043
Score = 104 bits (259), Expect = 3e-22
Identities = 97/378 (25%), Positives = 164/378 (43%), Gaps = 44/378 (11%)
Query: 376 PEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTE 435
PE G S E+ + + H K + + + + + E K +
Sbjct: 587 PEEKEGAEDSKGNGIEEQEVEANEENVKVHGGR-KEKTEILSDDLTDKAEVSEGKAKSVG 645
Query: 436 DGGEFEEGASENNAKESSP------EKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGN 489
+ + EG + +E S ++E E+G EK+ G +R EG E EE
Sbjct: 646 EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG--EKDKGRGEMERPGEGEKELAEKEEWK 703
Query: 490 PVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEK--- 546
G E++ ++E + +N E G +E + E EEE G +E EE + E
Sbjct: 704 KRDGEEQEQKEREQGHQKERNQEMEEGGEEE-----HGEGEEEEGDREEEEEKEGEGKEE 758
Query: 547 -ESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
E +E E++ E+G ++ E G E+ +EEG ++ + E E E
Sbjct: 759 GEGEEVEGEREKEEGERKKEERAGKEEKGEEEG--------------DQGEGEEEETEGR 804
Query: 606 GSEKVLDEEGSE---REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK 662
G EK EEG E E +E E+EEEE+ E ++ E+E+ E +E+G +++
Sbjct: 805 GEEK---EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEE 861
Query: 663 AEEGDADEKLFEESDDKEDEDADGKEVE----DADEKLFEDDDSNEKLFDEEEDSSEKLF 718
EEG+ +E+ E + E+E+ +G+ E + +E+ E + E + EE+ E
Sbjct: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
Query: 719 DDSDERGTLGGFGSVEEG 736
++ E G G G EEG
Sbjct: 922 EEEGEEGE--GEGEEEEG 937
Score = 102 bits (254), Expect = 1e-21
Identities = 128/532 (24%), Positives = 219/532 (41%), Gaps = 50/532 (9%)
Query: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
+GDG C E A DE+ +G K + + +++ + K+ + +++KK+
Sbjct: 654 RGDGTC----EEGSSGAEHWQDEEREKGEK---DKGRGEMERPGEGEKELAEKEEWKKRD 706
Query: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
+Q+Q ER G + R++ + H E++ D E K G+
Sbjct: 707 GEEQEQ----KEREQGHQKERNQEMEEGGEEEHGEGEEEEG--------DREEEEEKEGE 754
Query: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
++ +G R+ EE + + G+ G + Q + + EET
Sbjct: 755 GKE------EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG-----EGEEEETEG 803
Query: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSAS--ERAGPSRARHFSEHPSTSKMNAQETAT 418
EE+ G E E +G R + E G + +E
Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
Query: 419 GMAFEEPIDEKKFEKTEDGGEFE---EGASENNAKESSPEKEAEEGCPEKESEEGCPKRG 475
EE +E + E E+ GE E EG E +E E E EEG E E EEG K
Sbjct: 864 EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGE-EEGEGEGEEEEGEGKGE 922
Query: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
EG + E EE E+ + E ++ + + EE E E++ E EE G
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG--EGEGEEEGEGEGEEGEG- 979
Query: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
E EE++ E E +E+ E++ E+ E E E G E + +EEG E ++ E E
Sbjct: 980 --EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG-EGEEEEEGEV----EGEVEGEEGEG 1032
Query: 596 DSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKG 655
+ E E E++G E+ ++EG E + +E+EEEE Y++ ++E++ ++ EEY
Sbjct: 1033 EGEEEEGEEEGEER--EKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSK 1090
Query: 656 LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
++ + K + +K + E V+ ++L ++ S K F
Sbjct: 1091 IKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ--SKRLLKNGPSGSKKF 1140
Score = 72.8 bits (177), Expect = 1e-12
Identities = 92/361 (25%), Positives = 147/361 (40%), Gaps = 59/361 (16%)
Query: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEG-- 443
DS E + + +H S Q T AF + +E + + ++G E +G
Sbjct: 543 DSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD--EEVEIPEEKEGAEDSKGNG 600
Query: 444 -------ASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEE 496
A+E N K KE E + +++ G S E+E+G RG
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVG--EAEDGPEGRGD-- 656
Query: 497 DSPKKESKKKTLKNDCEENGLAKES-EDDLNKESEEEVGPTKESEEDDSEKESDEDCSEK 555
CEE E +D+ ++ E++ G + + EKE E E
Sbjct: 657 -------------GTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK-EEW 702
Query: 556 QSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEG 615
+ DG E+E +E E+G +KE ++ E+EE E +G E EEG
Sbjct: 703 KKRDGEEQEQKER-------EQGHQKERNQ-----EMEEGGEEE---HGEGEE----EEG 743
Query: 616 SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEE 675
E E+ E E +E+ + + E EKE+ E E+ +K EEGD E EE
Sbjct: 744 DREE--EEEKEGEGKEEGEGEEVEGER-EKEEGERKKEERAGKEEKGEEEGDQGEGEEEE 800
Query: 676 SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEE 735
++ + +E +G EVE + ++ E+ +EEE E+ + +E G G EE
Sbjct: 801 TEGRGEEKEEGGEVEGGE----VEEGKGEREEEEEEGEGEEEEGEGEEE---EGEGEEEE 853
Query: 736 G 736
G
Sbjct: 854 G 854
Score = 35.8 bits (81), Expect = 0.15
Identities = 44/209 (21%), Positives = 85/209 (40%), Gaps = 32/209 (15%)
Query: 561 SEREFEENGL-EKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK--------VL 611
SER +E+ L E+DL + E + +LD+ +E + +NS + E ++
Sbjct: 451 SERNLQESVLSEQDL----MQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIM 506
Query: 612 DEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEK 671
+E+ +K++++ T ++ D + + D+ E+ E + KA + +
Sbjct: 507 SLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566
Query: 672 LFEESDDKEDEDADGKEVEDADEKLFEDD--------------DSNEKLFDEEEDSSEKL 717
+F E +EVE +EK +D + N K+ ++ +E L
Sbjct: 567 IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEIL 626
Query: 718 FDDSDER-----GTLGGFGSVEEGPLSTG 741
DD ++ G G E+GP G
Sbjct: 627 SDDLTDKAEVSEGKAKSVGEAEDGPEGRG 655
Score = 31.2 bits (69), Expect = 3.7
Identities = 53/232 (22%), Positives = 81/232 (34%), Gaps = 29/232 (12%)
Query: 512 CEENGLAKE--SEDDLNKESEEEV---GPTKESEEDDSEKESDEDCSEKQSEDGSEREFE 566
C E L + SE DL + E + TKE+E D+S + E E
Sbjct: 450 CSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSS--TVESLGETTDILNMTHIMS 507
Query: 567 ENGLEKDL-----DEEGSEKELHENVLDKELEENDS--ENSEFEDDGSEKVLDEEGSERE 619
N EK L ++ ++ + E D L END E E + K + S+
Sbjct: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI 567
Query: 620 F------------DED---SDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAE 664
F DE+ +EKE ED+ +++ E +E G + +
Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS 627
Query: 665 EGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
+ D+ E K +A+ D E E DEE + EK
Sbjct: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 87.4 bits (215), Expect = 4e-17
Identities = 62/350 (17%), Positives = 127/350 (36%), Gaps = 15/350 (4%)
Query: 374 NAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEK 433
N+ +++ SDS +S + S + S +S N+ +++ + D
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD------ 987
Query: 434 TEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRG 493
+ D + + + +N+ +SS ++ + +S S +S + +
Sbjct: 988 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047
Query: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
S + S S + +D ++ + +S D + + + S + +S +
Sbjct: 1048 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSD 1107
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
S D S+ N + + S+ N D +DS S D S+
Sbjct: 1108 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS----SDSSESSDSSDSSDSSDSS 1163
Query: 614 EGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLF 673
+ S+ DS + D+ + D SD + + +D +++D +D
Sbjct: 1164 DSSDSSDSSDSSDSSNSSDSSDS--SDSSDSSDSSDSSDSS--DSSDSSDSSDSSDSSDS 1219
Query: 674 EESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
+S D D +D E D+ + D SN + DSS+ D +DE
Sbjct: 1220 SDSSDSSDS-SDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268
Score = 85.5 bits (210), Expect = 2e-16
Identities = 74/336 (22%), Positives = 125/336 (37%), Gaps = 27/336 (8%)
Query: 436 DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGN--PVRG 493
D +F++ + + + SS E + ES+ RG S + + GN +G
Sbjct: 451 DSYDFDDKSMQGDDPNSSDESNGNDDA-NSESDNNSSSRGDASYNSDESKDNGNGSDSKG 509
Query: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
+E+D +S + N+ + NG DD N +S+ G + S+ D S+ + D S
Sbjct: 510 AEDD----DSDSTSDTNNSDSNGNGNNGNDD-NDKSDSGKGKSDSSDSDSSDSSNSSDSS 564
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGS---EKELHENVLDKELEENDSENSEFEDDGSEKV 610
+ D S+ + D D S + N D + +DS +S D S+
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS-DSSDSSDSSDSSDSSDSK 623
Query: 611 LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKED------------EEYADEKGLEA 658
D SE + DSD K + D+ D SD + + +D
Sbjct: 624 SDSSKSESD-SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD 682
Query: 659 ADKKAEEGDADE--KLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
+ ++ D+ + E SD + D+D + D+ D DS+ + +S
Sbjct: 683 SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD 742
Query: 717 LFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDD 752
D SD + S + S S SSD D
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778
Score = 84.0 bits (206), Expect = 5e-16
Identities = 66/372 (17%), Positives = 130/372 (34%), Gaps = 11/372 (2%)
Query: 385 SDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFE--EPIDEKKFEKTEDGGEFEE 442
SDS +S+ S S SK ++ ++ + + + + D + D + +
Sbjct: 614 SDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSD 673
Query: 443 GASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKE 502
+ +++ +SS ++ + S E S S S+ N + S +
Sbjct: 674 SSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSD 733
Query: 503 SKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE 562
S + +D ++ + S D + +S + + S+ DS SD S ++ +
Sbjct: 734 SSDSSNSSDSSDSSDSSNSSD--SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS 791
Query: 563 REFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDE 622
+ ++ D + ++ +DS NS D S + S+
Sbjct: 792 SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851
Query: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKED- 681
DSD + + D SD + +D + ++ D+ +S D +
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Query: 682 -EDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLST 740
+ +D D+ E D+SN DSS DS + + + S+
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS-----DSSDSSNSSDSSNSSDSSNSS 966
Query: 741 GSSFILSSDDDD 752
SS SSD D
Sbjct: 967 DSSDSNSSDSSD 978
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/402 (17%), Positives = 141/402 (35%), Gaps = 30/402 (7%)
Query: 379 NRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA-------QETATGMAFEEPIDEKKF 431
++ ++ D S+ E G A S++ S+S+ +A ++ G + D+
Sbjct: 457 DKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDS- 515
Query: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV 491
+ T D + + NN + + + ++ +G + + S +S+ +
Sbjct: 516 DSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSN 575
Query: 492 RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDED 551
S+ DS +S + +D ++ + +S D + + + +S+ D S+ ESD
Sbjct: 576 SSSDSDSSDSDSSDSS-DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634
Query: 552 CSEKQSE--DGSEREFEENGLEKDLDEEGSEKELHENV-----------------LDKEL 592
S+ +S+ D + + +N D + + ++ D
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694
Query: 593 EENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
N SE+S+ D D S DSD + + D SD + +D
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 653 EKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEED 712
+ ++ D+ + + D D+ + D SN + D
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 713 SSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
SS+ D S+ + S + S S SSD D D
Sbjct: 815 SSDS--DSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/371 (15%), Positives = 132/371 (35%), Gaps = 3/371 (0%)
Query: 385 SDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGA 444
SDS ++S+ + S + + S+ ++ ++ + + D + D + + +
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSS 614
Query: 445 SENNAKES-SPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKES 503
+++ +S S ++E + +S+ S +S + + S + S +S
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS 674
Query: 504 KKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSER 563
+ +D + + +S D N + + +S+ DS S+ + S+ S + S+
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS 734
Query: 564 EFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDED 623
N + + S + D + S++S+ D + +
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS 794
Query: 624 SDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED 683
SD + + D SD + + ++D +D +S D D D
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 684 ADGK-EVEDADEKLFEDDDSNEKLFDEEEDSSEKL-FDDSDERGTLGGFGSVEEGPLSTG 741
+ + + ++ + D SN + DS+E DS + S + S
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 742 SSFILSSDDDD 752
S SSD +
Sbjct: 915 SDSSNSSDSSE 925
Score = 80.1 bits (196), Expect = 7e-15
Identities = 61/314 (19%), Positives = 112/314 (35%), Gaps = 11/314 (3%)
Query: 445 SENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESK 504
S+++ +SS +++ S+ + S S S+ + SE DS +SK
Sbjct: 580 SDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK 639
Query: 505 KKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSER- 563
+ ++ ++ +S D N + + + +S + S +S S D S
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699
Query: 564 EFEENGLEKDLDEEGSEKELHENVLDKEL----EENDSENSEFEDDGSEKVLDEEGSERE 619
E ++ D D S + N D + + +DS NS D S+ + S+
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 759
Query: 620 FDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDK 679
+S + + D+ D SD + D + + D+ + SD
Sbjct: 760 DSSNSSDSSDSSDS-----SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS-DSSDSS 813
Query: 680 EDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLS 739
+ D+D D+ D SN + DSS+ DS R + S
Sbjct: 814 DSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 740 TGSSFILSSDDDDD 753
+ SS S D ++
Sbjct: 874 SNSSDSSDSSDSNE 887
Score = 78.6 bits (192), Expect = 2e-14
Identities = 70/386 (18%), Positives = 135/386 (34%), Gaps = 21/386 (5%)
Query: 374 NAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS-KMNAQETATGMAFEEPIDEKKFE 432
N+ +++ SDS +S+ + S + S+ ++S ++ +++ D
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 433 KTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVR 492
+ D + + +N+ +SS ++ + S+ + S S S+ +
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESD-ED 551
GS+ DS + +D + + +S D N + + ES +S SD +
Sbjct: 850 GSDSDSSNR--------SDSSNSSDSSDSSDSSNSSDSSDSSDSNESS--NSSDSSDSSN 899
Query: 552 CSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDK-----ELEENDSENSEFEDDG 606
S+ S D S + E S + N D + +DS NS +
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959
Query: 607 SEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEG 666
S+ + S+ + SD + + D SD + +D + +
Sbjct: 960 SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSS 1019
Query: 667 DADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGT 726
D+ + + +D + D+ + D SN + DSS D SD +
Sbjct: 1020 DSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS----DSSDSSDS 1075
Query: 727 LGGFGSVEEGPLSTGSSFILSSDDDD 752
S E S S+ SSD D
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSD 1101
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/381 (16%), Positives = 130/381 (34%), Gaps = 19/381 (4%)
Query: 374 NAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS-KMNAQETATGMAFEEPIDEKKFE 432
N+ +++ SDS ++S + S + S+ S+S N+ +++ +
Sbjct: 646 NSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS 705
Query: 433 KTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVR 492
+ D + S N+ S + + S + S +S + +
Sbjct: 706 DSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
Query: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDC 552
S + S +S + +D ++ + +S D N + +S D S+ +S
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS-DSSDSDSSNSS 824
Query: 553 SEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLD 612
S D S+ + + +GS+ + +DS NS D S+
Sbjct: 825 DSSNSSDSSDSSNSSDSSDSSDSSDGSDSD--------SSNRSDSSNSSDSSDSSDSSNS 876
Query: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672
+ S+ DS+E D+ +S D + +D + + D+ E
Sbjct: 877 SDSSD---SSDSNESSNSSDS------SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 673 FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGS 732
+ + ++ + D+ + D SN DSS+ DS +
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987
Query: 733 VEEGPLSTGSSFILSSDDDDD 753
+ S+ SS +S D D
Sbjct: 988 SSDSSDSSDSSDSSNSSDSSD 1008
Score = 76.6 bits (187), Expect = 8e-14
Identities = 72/381 (18%), Positives = 126/381 (33%), Gaps = 21/381 (5%)
Query: 385 SDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGA 444
SDS S+ S S S S ++ + + + + D K E + + +
Sbjct: 583 SDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDS 642
Query: 445 SENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESK 504
S++N+ +SS ++ + S + S S +S + S + S ES
Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS 702
Query: 505 KKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQ-SEDGSER 563
+ +D + + +S D N S + D S D S+ S D S+
Sbjct: 703 DSSDSSDSDSS----DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 564 EFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN-SEFEDDG----------SEKVLD 612
N + + S+ N D NDS N S+ D S D
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDS----NDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGD-ADEK 671
S+ DS + D+ +S + D +D + ++ D +D
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874
Query: 672 LFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFG 731
+S D D + + +D D DS++ + S D S+ +
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934
Query: 732 SVEEGPLSTGSSFILSSDDDD 752
S + S S SS+ D
Sbjct: 935 SSDSSNSSDSSDSSDSSNSSD 955
Score = 70.1 bits (170), Expect = 7e-12
Identities = 78/333 (23%), Positives = 127/333 (38%), Gaps = 25/333 (7%)
Query: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV 491
E ++G +E N K+SS + +EG + ++ G + EG
Sbjct: 253 EDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKED 312
Query: 492 RGSEEDSPKKESKKKTLKNDCEENGLAK-ESEDDLNKESEEEVGP--TKESEEDDSEKES 548
+E D K ++ E+NG + E LN + V TKESE K
Sbjct: 313 PHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQ 372
Query: 549 DEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSE 608
D+ K G+ +E G +E +K H +L K + E E G +
Sbjct: 373 DKGIEIKGPSSGNRNITKEVGKG---NEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQK 429
Query: 609 KVLDEEGSE-REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEK------GLEAADK 661
E G++ + SD + D+Y+ FDD+S + +D +DE E+ +
Sbjct: 430 ---SEPGNKVGHSNTGSDSNSDGYDSYD--FDDKSMQGDDPNSSDESNGNDDANSESDNN 484
Query: 662 KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDS 721
+ GDA E D+ D+ G E +D+D D+N + + DD+
Sbjct: 485 SSSRGDASYNSDESKDNGNGSDSKGAEDDDSD----STSDTNN---SDSNGNGNNGNDDN 537
Query: 722 DERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
D+ + G + S S+ SSD D D
Sbjct: 538 DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSD 570
Score = 67.8 bits (164), Expect = 4e-11
Identities = 78/392 (19%), Positives = 150/392 (38%), Gaps = 33/392 (8%)
Query: 373 LNAPEANRGLRRSDSVSASERAGPSRARHFS-EHPSTSKMN-AQETATGMAFEEPIDEKK 430
LN E+ R R S + G S+ + + PS+ N +E G +E K
Sbjct: 347 LNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKG-------NEGK 399
Query: 431 FEKTEDGGEFEEGASENNAKE---SSPEKEAEEGCPEKESEEGCPKR--GFEGSCSQKES 485
+K + G +G + + P +++E G S G G++ +S
Sbjct: 400 EDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKS 459
Query: 486 EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSE 545
+G+ S+E + ++ ++ N + S++ + + + +K +E+DDS+
Sbjct: 460 MQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSD---SKGAEDDDSD 516
Query: 546 KESDEDCSEKQSE-----DGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
SD + S+ D +++ G D + S+ + D ++DS +S
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSS--DSDSSDS 574
Query: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660
D D S+ DSD + + D SD + + +D K +++
Sbjct: 575 NSSSDS-----DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS-DSSK 628
Query: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
+++ D+D K + SD + +D + D+ D S+ D + SS +
Sbjct: 629 SESDSSDSDSK-SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS--DSSDSSSSSDSSN 685
Query: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDD 752
S + + E S+ SS SSD D
Sbjct: 686 SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD 717
Score = 60.1 bits (144), Expect = 7e-09
Identities = 77/328 (23%), Positives = 138/328 (42%), Gaps = 28/328 (8%)
Query: 436 DGGEFEEGASENNAKESSPEKEAEEGCPEK---ESEEGCPKRGFEGSCSQKESEEGNPVR 492
+G E N+ + + E E G E ++ +G P G+ + ++ +EG+
Sbjct: 207 EGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPS----GNGADEDEDEGSGDD 262
Query: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDC 552
EE K+S + + +++G + + + + S+ + E +ED E D D
Sbjct: 263 EDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDP-HNEVDGDK 321
Query: 553 SEKQSEDGSEREFEENGLEKDLDEEG---SEKELHENVLDKELEENDSENSEFEDDGSEK 609
+ K SE+ S E+NG ++ D + E + EN + KE E + S+ D G E
Sbjct: 322 TSK-SEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQ--DKGIEI 378
Query: 610 VLDEEGSEREFDEDSDEKEEEEDTYEK-VFDDESDEKEDEEYADEKGLEAADKKAEEGDA 668
G+ E E +ED + + + + K E + +E +K+E G+
Sbjct: 379 KGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN---IEGPGQKSEPGNK 435
Query: 669 DEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDE---EEDSSEKLFDDSDERG 725
S+ D ++DG + D D+K + DD N DE +D++ + ++S RG
Sbjct: 436 ----VGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSS--DESNGNDDANSESDNNSSSRG 489
Query: 726 TLGGFGSVEEGPLSTGSSFILSSDDDDD 753
+ S E GS + DDD D
Sbjct: 490 D-ASYNSDESKDNGNGSDSKGAEDDDSD 516
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 87.4 bits (215), Expect = 4e-17
Identities = 103/454 (22%), Positives = 194/454 (42%), Gaps = 47/454 (10%)
Query: 338 GGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGL--RRSDSVSASERAG 395
G Q + + WDG+ + E+ S++ +ER R + + E++ L R+ + + G
Sbjct: 152 GKAQKSNKKWDGSEED--EDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG 209
Query: 396 PSRARHFSEHPSTSKMN--AQETATGMAFEEPI---DEKKFEKTEDGGEFEEGASENNAK 450
P+ + ++ K+ AQ+ A E ++ K K ++ E E G + + +
Sbjct: 210 PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269
Query: 451 ESSPEKEAEEGC-----------PEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSP 499
+ S K EE P E + P + + K+ ++ +G +E+
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE 329
Query: 500 KKESK---KKTLKNDCEENGLAKESEDDLNKESEEEVG-----PTKESEEDDSEKESDED 551
K++ K K T+K E KE E+ +E EE + K EE+ E+E E
Sbjct: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
Query: 552 CSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS-----EFEDDG 606
+K+ E + E L K E + E +L + E S++S +D
Sbjct: 390 KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDK 449
Query: 607 SEKVLDEEGSEREFDEDSD----EKEEEEDTYEKVFDDESDEKEDEEYADEKGLE----- 657
K + ++ +E E + + E+ EK E E+EE ++ GL+
Sbjct: 450 KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAM 509
Query: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
A+D++ E+ + ++ E ++ E+E+ + +E E+ +E E+++ E E ++ EK+
Sbjct: 510 ASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKV 569
Query: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDD 751
D+ D TL S E +S+ S + SDDD
Sbjct: 570 SDEKDSGKTLDKKPSKE---MSSDSEY--DSDDD 598
Score = 73.9 bits (180), Expect = 5e-13
Identities = 92/338 (27%), Positives = 149/338 (44%), Gaps = 58/338 (17%)
Query: 415 ETATGMAFEEPIDEKKFEKTEDGGEFEEGASENN---------AKESSPEKEAEEGCPEK 465
ET T + D+KK +K + GE EE E A + + K EE +K
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQK 359
Query: 466 ESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENG-LAKESEDD 524
EE KR E +KE E R +E +K+ K+K K ++ G L +S+ +
Sbjct: 360 REEEERIKRLEELEAKRKEEE-----RLEQEKRERKKQKEKERKERLKKEGKLLTKSQRE 414
Query: 525 LNKESEEEVG---------PTKES-------EEDDSEKESDEDCSEKQSEDGSER----E 564
+E + P+K+S ED K+ + K+ + E E
Sbjct: 415 ARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVE 474
Query: 565 FEENGL-EKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSER--EFD 621
E G+ EK+ E E E+ D L++ ++ S D+ +EKV EG++ E
Sbjct: 475 VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMAS---DEETEKV---EGNKVHIEVK 528
Query: 622 EDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGD-ADEKLFEESDDKE 680
E+ +E+EEEE+ E+ D+ES+E+E+EE + + EGD DEK+ +E D +
Sbjct: 529 ENPEEEEEEEEEEEE--DEESEEEEEEE---------GESEGSEGDEEDEKVSDEKDSGK 577
Query: 681 DEDADGKEVEDADEKLFEDDD--SNEKLFDEEEDSSEK 716
D + +D + DDD E+ +D+ + EK
Sbjct: 578 TLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615
Score = 73.6 bits (179), Expect = 7e-13
Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 24/316 (7%)
Query: 375 APEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKT 434
A + N G ++ + + + + PS + + A + A EE +K+ E+
Sbjct: 305 AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364
Query: 435 EDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV--- 491
E A + EK + EKE +E K G + SQ+E+
Sbjct: 365 RIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424
Query: 492 ----RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKE 547
+G E S KK+ + D + + ++ E ES E + E+ EKE
Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE 484
Query: 548 SDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGS 607
E + E+ +E ++ DEE + E N + E++EN E
Sbjct: 485 ETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE--GNKVHIEVKENPEEE-------- 534
Query: 608 EKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGD 667
+EE E E DE+S+E+EEEE E DE DEK +E K L DKK +
Sbjct: 535 ----EEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTL---DKKPSKEM 587
Query: 668 ADEKLFEESDDKEDED 683
+ + ++ DD+ E+
Sbjct: 588 SSDSEYDSDDDRTKEE 603
Score = 65.5 bits (158), Expect = 2e-10
Identities = 83/332 (25%), Positives = 150/332 (45%), Gaps = 34/332 (10%)
Query: 403 SEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC 462
+E TSK ++ G ++ D+ E+ ED ++ S+ AK P+ E G
Sbjct: 87 NEEEFTSKDKKKKGQKGK--KQSFDDNDSEELED----KDSKSKKTAK---PKVEMYSGS 137
Query: 463 PEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPK-KESKKKTLKNDCEENGLAKES 521
+ + PK+ +G +QK +++ + GSEED K+ K+++ N E+G ES
Sbjct: 138 DDDDDFNKLPKKA-KGK-AQKSNKKWD---GSEEDEDNSKKIKERSRINSSGESG--DES 190
Query: 522 EDDLN------KESEEEVGPTKES-EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDL 574
++ L K + + GP ES EDD + ++K++E ERE ++ EK
Sbjct: 191 DEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEK-KERERKKRDEEKAK 249
Query: 575 DEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEG-----SEREFDEDSDEKEE 629
+ EKE E + ++ +S+ E+ KV + G E+ + E +
Sbjct: 250 LRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309
Query: 630 EEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEV 689
E D +K + EKE++E +KG A KA + + EE K +E+ K +
Sbjct: 310 EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRL 369
Query: 690 EDADEKLFEDD----DSNEKLFDEEEDSSEKL 717
E+ + K E++ + E+ +E++ E+L
Sbjct: 370 EELEAKRKEEERLEQEKRERKKQKEKERKERL 401
Score = 62.4 bits (150), Expect = 2e-09
Identities = 63/272 (23%), Positives = 119/272 (43%), Gaps = 35/272 (12%)
Query: 461 GCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
G +K E K + E E + E K + KK+ K D +E+ + KE
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
Query: 521 SEDDLNKESE--------EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEK 572
E +L+ E++ V PT+ +EE+ + K+ +K+ + G ++ F++N E+
Sbjct: 62 LE-ELSLEAQGIKADRETVAVKPTENNEEEFTSKD-----KKKKGQKGKKQSFDDNDSEE 115
Query: 573 DLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEED 632
D++ K+ + ++ S+ +DD ++ +G ++ ++ D EE+ED
Sbjct: 116 LEDKDSKSKKTAKPKVEM------YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDED 169
Query: 633 TYEKVFD-------DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDAD 685
+K+ + ES ++ DE KG + ++K + G E ED+DA
Sbjct: 170 NSKKIKERSRINSSGESGDESDEFLQSRKG-QKKNQKNKPGPNIE------SGNEDDDAS 222
Query: 686 GKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
K ++ +K E + K DEE+ KL
Sbjct: 223 FK-IKTVAQKKAEKKERERKKRDEEKAKLRKL 253
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/179 (26%), Positives = 87/179 (48%), Gaps = 18/179 (10%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRG---FEGSCSQKES 485
++ E E E A+ ++ PEKE E E EE G +E S +E+
Sbjct: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515
Query: 486 E--EGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE-ED 542
E EGN V +++P++E +++ +E ED+ ++E EEE G ++ SE ++
Sbjct: 516 EKVEGNKVHIEVKENPEEEEEEEE-----------EEEEDEESEEEEEEEGESEGSEGDE 564
Query: 543 DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSE 601
+ EK SDE S K + +E + E D D++ +++E + + +E+ E+S+
Sbjct: 565 EDEKVSDEKDSGKTLDKKPSKEMSSDS-EYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 87.0 bits (214), Expect = 6e-17
Identities = 85/327 (25%), Positives = 141/327 (43%), Gaps = 32/327 (9%)
Query: 406 PSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEK 465
P S ++E A + +E + D E + A +S E+ + +
Sbjct: 219 PQVSDSESEEPPRHQASDSENEELPKPRISDSES--EDPPRHQASDSENEELPKPRISDS 276
Query: 466 ESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDL 525
ESE+ P R + S S+ E V SE + P+K + D + ES+DD
Sbjct: 277 ESED--PPRN-QASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDS 333
Query: 526 NKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE-EGSEKELH 584
++E++ G E + D +S D + S D E E ++ ++ D DE EG E+++
Sbjct: 334 DRENK---GEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVA 390
Query: 585 ENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDE 644
+ K +DSE+ E +V+ + D DSD ++ EK +S+E
Sbjct: 391 KR---KAAVLSDSEDEEKASAKKSRVVSDAD-----DSDSDAVSDKSGKREKTIASDSEE 442
Query: 645 KEDEEYADEKGLEAA--DKKAEEGDADEKL----FEESDDKEDEDADGKEVEDADEKLFE 698
+ +E +D+K E +E G+ +E L F ES D+E+E+ G ED +E
Sbjct: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE---- 498
Query: 699 DDDSNEKLFDEEEDSSEKLFDDSDERG 725
+ E E EDS DD+ +RG
Sbjct: 499 --EKGETQVKEAEDSDS---DDNIKRG 520
Score = 85.9 bits (211), Expect = 1e-16
Identities = 76/336 (22%), Positives = 135/336 (40%), Gaps = 36/336 (10%)
Query: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPV 491
++ + G + E+ +E ++ + E + E+G PK G+ V
Sbjct: 21 DERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK--------------GHHV 66
Query: 492 RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDED 551
SE D P + +D E L ++ + D E E + ED ++ SD +
Sbjct: 67 TDSENDEPLNLN-----ASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSE 121
Query: 552 CSEKQSEDGSEREFEE--NGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK 609
E + GS+ E EE NG D + E K + +EL+++ + +SE ED +
Sbjct: 122 SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQ 181
Query: 610 VLDEEGSEREFDEDSD------------EKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
+ D E E + SD + E EE +V D ES+E + +D + E
Sbjct: 182 ISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEE 241
Query: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
+ + ++++ ++ D E+E+ + D++ ED N+ E E+ +
Sbjct: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSES---EDPPRNQASDSENEELPKPR 298
Query: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDD 753
DS+ G G S E ++ SDDD D
Sbjct: 299 VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSD 334
Score = 79.0 bits (193), Expect = 2e-14
Identities = 99/406 (24%), Positives = 165/406 (40%), Gaps = 42/406 (10%)
Query: 377 EANRGLRRSDSVSA---SERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEK 433
E R L SDS + + A S +HP+ S +E A + ++ +
Sbjct: 123 EETRKLPGSDSENEELLNGHASDSENEDVGKHPA-SDSEIEELQKSPASDSETEDALKPQ 181
Query: 434 TEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRG 493
D E EE + A +S E+ + + ESEE PK S ESEE P R
Sbjct: 182 ISDS-ESEE-PPRHQASDSENEEPPKPRMSDSESEE-LPKP----QVSDSESEE--PPRH 232
Query: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
DS +E K + + E+ ++ D N+E + ESE+ + SD +
Sbjct: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENE 292
Query: 554 E--KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE-ENDSENSEFEDDGSEKV 610
E K SE E + G D + E + + + D + + EN E++E ++D
Sbjct: 293 ELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHS- 351
Query: 611 LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEE----- 665
+ +R+ SD +EEE + D++ E E+E+ A K +D + EE
Sbjct: 352 --DSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK 409
Query: 666 -----GDADEKLFEESDDK----------EDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
DAD+ + DK + E+ GKE+ D + + S+ + +EE
Sbjct: 410 KSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEE 469
Query: 711 EDSSEKLFDDS--DERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
E+ +F +S +E GF E+ G + + ++D D D
Sbjct: 470 ENLIADIFGESGDEEEEEFTGFNQ-EDLEEEKGETQVKEAEDSDSD 514
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 25/197 (12%)
Query: 528 ESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENV 587
+ ++ G T +E DS + ++D +E+ S GS+ +E+ + E S++E +
Sbjct: 9 DQSDDGGATPVQDERDSGSDGEDDVNEQHS--GSDT----GSVERHSENETSDRE---DG 59
Query: 588 LDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESD-EKE 646
L K DSEN E L+ S+ E +E +K+ + ++ E+ SD E E
Sbjct: 60 LPKGHHVTDSENDE--------PLNLNASDSESEELHRQKDSDSESEERAEPPASDSENE 111
Query: 647 D--EEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED-----ADGKEVEDADEKLFED 699
D + +D + E + + +E L + D E+ED A E+E+ + D
Sbjct: 112 DVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASD 171
Query: 700 DDSNEKLFDEEEDSSEK 716
++ + L + DS +
Sbjct: 172 SETEDALKPQISDSESE 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 41/149 (27%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 596 DSE--NSEFEDDGSEK-VLDEEGSEREFDEDSDEKEEEEDT--YEKVFDDESDEKEDEEY 650
DSE + + DDG V DE S + ++D +E+ DT E+ ++E+ ++ED
Sbjct: 2 DSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDRED--- 58
Query: 651 ADEKGLEAADKKAEEG---DADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
KG D + +E +A + EE ++D D++ +E + E++D N+
Sbjct: 59 GLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGS 118
Query: 708 DEEEDSSEKL-FDDSDERGTLGGFGSVEE 735
D E + + KL DS+ L G S E
Sbjct: 119 DSESEETRKLPGSDSENEELLNGHASDSE 147
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 86.7 bits (213), Expect = 7e-17
Identities = 135/617 (21%), Positives = 250/617 (40%), Gaps = 97/617 (15%)
Query: 158 IIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAK 217
I++ + + E K+K+ K ++ + K + +K E E K DE ++ K +
Sbjct: 672 ILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFK--DEKSLKRIKDTNKDIS 729
Query: 218 FQLKGEYDASKKKKKCKDYKKKLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDF 277
+ E D S K +K + K+K ++K ++ ER+ S+ R ++ ++
Sbjct: 730 RSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKK-KSKDRPSKLEKKNDLKEDKIS 788
Query: 278 EDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFRDPEEADYCIQTLD-GRW 336
++ + E +E L+ E R+ FD + + F + E+ + + RW
Sbjct: 789 KEKEKIFKEDKEKLKKE----KVYREDSAFDEYCN---KNQFLENEDTKFSLSDDQRDRW 841
Query: 337 FGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVS------- 389
F D + D++ E++ W++ P + +SDSV+
Sbjct: 842 FSDLS------DSSFDFKGEDS----------WDS----PVTDYRDMKSDSVAKLILETV 881
Query: 390 ---ASERAGPSRARHFSEH-------------PSTSKMNAQETATGMAFEEPIDEKKFEK 433
+ ER SRAR ++ S+ ++T + + EK ++
Sbjct: 882 KEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKR 941
Query: 434 TEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQK-ESEEGNPVR 492
E E G +A ES E+ PE+ E + G E K + + G +
Sbjct: 942 RESA---EAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLE 998
Query: 493 GSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDC 552
E P +E +KK +G KE ++ E +E K S++D SEK E C
Sbjct: 999 PWERHHPAREKEKK--------DGPDKERKEKTKPERYKE----KSSDKDKSEKSILEKC 1046
Query: 553 SEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLD 612
+ + D +E +++ EK D G +KE ++ + ++ + +D SEK D
Sbjct: 1047 QKDKEFDKCFKE-KKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDD 1105
Query: 613 EEGSEREF---DEDSDEKEEEEDTY-----------EKVFDDESDEKED--EEYADEKGL 656
++G E+ + D +DE E++ D+ + D EKE+ E YA ++
Sbjct: 1106 KKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHR 1165
Query: 657 EAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFE------DDDSNEKLFDEE 710
+++DK+ E D++ + D+ DA D EK+FE D +S EK D +
Sbjct: 1166 KSSDKQHPERQKDKEPRDRRKDRGAADAG----RDKKEKVFEKHKEKKDKESTEKYKDRK 1221
Query: 711 EDSSEKLFDDSDERGTL 727
+ +S D + L
Sbjct: 1222 DRASVDSTQDKKNKQKL 1238
Score = 72.0 bits (175), Expect = 2e-12
Identities = 130/623 (20%), Positives = 249/623 (39%), Gaps = 87/623 (13%)
Query: 98 EEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFG 157
E +EK+P+ R E+RK +S +DR + + D+ D+ + K
Sbjct: 745 ERSLKEKSPKEEKLRLYKEERKKKS------KDRPSKLEKKN---DLKEDKISKEKEK-- 793
Query: 158 IIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAK 217
I ++ + + K K+Y+++ + +L+ E + +L +D+ + + +
Sbjct: 794 -IFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLS---DDQRDRWFSDLSDSS 849
Query: 218 FQLKGEYDASKKKKKCKDYKK----KLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFH 273
F KGE +D K KL ++ + D + RR SR R +R +
Sbjct: 850 FDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRR--DSRAREKR-----DYRE 902
Query: 274 PMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFRDPEEA-DYCIQTL 332
P + D L++ E + + K + L ++ + RD ++A + C +
Sbjct: 903 PFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERR 962
Query: 333 DGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASE 392
DGR + EE RE + F + + + G + E
Sbjct: 963 DGR-----------------AKPEEAHREELKECGCESGFKDKSDGDFG----KGLEPWE 1001
Query: 393 RAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKES 452
R P+R + + P + E+ E+ EK+ D + E+ E K+
Sbjct: 1002 RHHPAREKEKKDGPDKERK-----------EKTKPERYKEKSSDKDKSEKSILEKCQKDK 1050
Query: 453 SPEKEAEEGCPEKESEEGCPKRGFEGSCS----QKESEEGNPVRGSEEDSPKKESKKKTL 508
+K +E KE + + E S +++ E+ P SE+ S KK+ KK
Sbjct: 1051 EFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKE 1110
Query: 509 KNDCEENGLAKESEDDLNK--ESEEEVGPTKESEEDDSEKESDED-----------CSEK 555
K+ + ESEDD + S ++G + D +E +E S+K
Sbjct: 1111 KSWYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDK 1170
Query: 556 QSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEG 615
Q + +++ E KD + ++ E V +K E+ D E++E D ++ +
Sbjct: 1171 QHPE-RQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDST 1229
Query: 616 SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEE 675
+++ + EK E++ E + EK D+E++ E+ K + DA++ L E
Sbjct: 1230 QDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKER------KSSRSADAEKSLLE- 1282
Query: 676 SDDKEDEDADGKEVEDADEKLFE 698
K +E+A + ED+++K+ E
Sbjct: 1283 ---KLEEEALHEYREDSNDKISE 1302
Score = 58.5 bits (140), Expect = 2e-08
Identities = 84/369 (22%), Positives = 146/369 (39%), Gaps = 52/369 (14%)
Query: 376 PEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTE 435
PE ++ + S+ S H E S+ +A+++ EE + E + + +
Sbjct: 1239 PEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSND 1298
Query: 436 DGGEFEEGASENNAKESS--------------PEKEAEEGC-PEKESEEGCPKRGFEGSC 480
E + + +E +K E C PEK E+ +R S
Sbjct: 1299 KISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEK---ERHRHSSS 1355
Query: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKES----EDDLNKESEEEVGPT 536
S K+S + E + K++++KK D +E G K+S +D L ++
Sbjct: 1356 SSKKSHD-------RERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNM 1408
Query: 537 KESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEND 596
K ED+ +K + +EK+ ++ SERE +EK+L GS N+L KE ++ +
Sbjct: 1409 KADIEDELDKTIELFSTEKKDKNDSERE-PSKKIEKELKPYGSSA---INIL-KEKKKRE 1463
Query: 597 SENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGL 656
EK DE+ R+ D + ++ D++ D+ D
Sbjct: 1464 KHR--------EKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDK---DSPPR 1512
Query: 657 EAADKKAEEGD--ADEKLFEE-SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDS 713
DK +EG D KL E+ D E E D ++ + ++K+ D +K +
Sbjct: 1513 VLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKK----DARP 1568
Query: 714 SEKLFDDSD 722
EKL D D
Sbjct: 1569 REKLLGDGD 1577
Score = 55.5 bits (132), Expect = 2e-07
Identities = 94/424 (22%), Positives = 155/424 (36%), Gaps = 83/424 (19%)
Query: 385 SDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGA 444
S SA+++ PS ++H T + D + T + EG+
Sbjct: 525 SHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGS 584
Query: 445 SENNAK----------------ESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
S + K + SP + EG K +EG + + K E+G
Sbjct: 585 SVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKG 644
Query: 489 NPVRGSE----------EDSPKKESKKKTLKNDCE-ENGLA--KESEDDLNKESE----- 530
E EDS +K K L+ND EN L K D KE +
Sbjct: 645 QCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMK 704
Query: 531 ---------------------EEVGPTKESEEDDSEK-ESDEDCSEKQSEDGSEREFEEN 568
+++ + E+D S K E + EK ++ R ++E
Sbjct: 705 LEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEE 764
Query: 569 GLEKDLDEEGS---EKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSD 625
+K D + +L E+ + KE E+ E+ E EKV E+ + FDE +
Sbjct: 765 RKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLK--KEKVYREDSA---FDEYCN 819
Query: 626 EKE--EEEDTYEKVFDDE--------SDEKEDEEYADEKGLEAADKKAEEGDADEKLFEE 675
+ + E EDT + DD+ SD D + D D + + D+ KL E
Sbjct: 820 KNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILE 879
Query: 676 S---DDKE-DEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFG 731
+ D KE D+ +E D E F D D + +SEK + +++ ++ G+
Sbjct: 880 TVKEDSKERRRDSRAREKRDYREPFFRKKDR-----DYLDKNSEKRKEQTEKHKSVPGYL 934
Query: 732 SVEE 735
S ++
Sbjct: 935 SEKD 938
Score = 49.3 bits (116), Expect = 1e-05
Identities = 71/359 (19%), Positives = 140/359 (38%), Gaps = 45/359 (12%)
Query: 387 SVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEG--- 443
S ++ G ++ + ++ + + +++ G F+ + +T+ E EEG
Sbjct: 1100 SEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMG-EASDLPRTDGLQEKEEGREA 1158
Query: 444 -ASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKE 502
AS+ + K S +K+ E +KE + RG + K+ + E+ KK+
Sbjct: 1159 YASDRHRKSS--DKQHPERQKDKEPRDRRKDRGAADAGRDKKEKV------FEKHKEKKD 1210
Query: 503 SKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE 562
+ D ++ ++D NK+ E K + ED ++ + E ++ S++
Sbjct: 1211 KESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKE--R 1268
Query: 563 REFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK------------- 609
+ EK L E+ E+ LHE D + ++ + F D G E
Sbjct: 1269 KSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEP 1328
Query: 610 ----------VLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAA 659
L E+ E+E S ++ E+ +++++KE E E G
Sbjct: 1329 PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGG---- 1384
Query: 660 DKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEK-LFDEEEDSSEKL 717
++ EK F E+D ++ED +K E + +K D E + S+K+
Sbjct: 1385 --SRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKI 1441
Score = 35.8 bits (81), Expect = 0.15
Identities = 57/271 (21%), Positives = 106/271 (39%), Gaps = 21/271 (7%)
Query: 488 GNPVRGSEE-DSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPT--KESEEDDS 544
GNP + + + ++P K + T+ N G SE+ + SEEE P+ S D +
Sbjct: 258 GNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGN 317
Query: 545 EKESDEDCSEKQSEDGSEREFEENGLEKDLD-EEGSEKELHENVLDKELEENDSENSEFE 603
+S+ + K E + ++ + + +E E++ V DK L + D E
Sbjct: 318 NTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRK---E 374
Query: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663
+ + + + + +++ ++ ++ D SDE ED G E A
Sbjct: 375 TKSNSFISIPKMEVKSYTKNNTIAPKKAS--HRILSDTSDE-EDASVTVGTG-EKLRLSA 430
Query: 664 EEGDADEKLFEESDDKEDEDADG------KEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
K E S+ K+ ++ + KE + + + + D F E SE
Sbjct: 431 HTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDK----FCSSESESESS 486
Query: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSS 748
D+R +LG G ++ PL + SS
Sbjct: 487 ESGEDDRDSLGSSGCLKGSPLVLKDPSLFSS 517
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/326 (23%), Positives = 148/326 (45%), Gaps = 37/326 (11%)
Query: 439 EFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKE-------SEEGNPV 491
E E S++ + S ++ A G SE +RG G S KE E +
Sbjct: 15 EAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHH 74
Query: 492 RGSEEDSPKKESKKKTL-KNDCEENGLA-------KESEDDLNKESEEEVGPTKESEEDD 543
GS+ S + +++ + ++D E+N + E+ +D E G + SE +
Sbjct: 75 SGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEG 134
Query: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE---GSEKELHENVLDKELEEN--DSE 598
SEK +D EK + + ++ ++ DEE GS+++ +N D E +N D E
Sbjct: 135 SEKAHSDD--EKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEE 192
Query: 599 NSEFEDDGSEKVLDEE--GSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGL 656
+ DD +++ +EE S+ E SD +E+++ SD++E + +DE+ +
Sbjct: 193 RPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQN---------SDDEEQPQLSDEEKM 243
Query: 657 EAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
+ +D + + +E + ++++D ++ D+++++ N D E DS +
Sbjct: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
Query: 717 LFDDSDERGTLGGFGSVEEGPLSTGS 742
+ D GT+ FG ++ +S+GS
Sbjct: 304 V--PKDNSGTMDLFGGADD--ISSGS 325
Score = 80.1 bits (196), Expect = 7e-15
Identities = 70/299 (23%), Positives = 129/299 (43%), Gaps = 18/299 (6%)
Query: 464 EKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKK-----ESKKKTLKNDCEENGLA 518
+ E+E G + Q+ + G+ GSE D ++ S K+ +D E+ G +
Sbjct: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGAS 72
Query: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE--REFEENGLEKDLDE 576
S D SE ++ SE D E D D S+ GSE + E+ G D
Sbjct: 73 HHSGSD--NHSERSDNRSEASERSDHE---DNDPSDVDQHSGSEAPNDDEDEGHRSDGGS 127
Query: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
SE E E + + + S+ DD EK+ + + ER D D+ + +D EK
Sbjct: 128 HHSEAEGSEKAHSDDEKWGREDKSDQSDD--EKIQNSDDEERAQGSDEDKLQNSDDD-EK 184
Query: 637 VFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-K 695
+ +D++E + +D++ + ++++ D + + ++DD++ D ++ + +DE K
Sbjct: 185 M--QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242
Query: 696 LFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
+ DD + DEE S+ + + + G S +E + I S + D D
Sbjct: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSD 301
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/291 (24%), Positives = 123/291 (42%), Gaps = 45/291 (15%)
Query: 478 GSCSQKESEEGNPVRGSEEDSPKKE----SKKKTLKNDCEENG-LAKESEDDLNKESEEE 532
GS + E+E + GS+ DS ++ S ++D +E G + S +L + E+
Sbjct: 9 GSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSED 68
Query: 533 VGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEE-GSEKELHENVLDKE 591
G + S D+ + SD + SER E+ D+D+ GSE
Sbjct: 69 EGASHHSGSDNHSERSDN------RSEASERSDHEDNDPSDVDQHSGSEAP--------- 113
Query: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
ND E+ DG + EGSE+ +D E D+SD+ +DE+
Sbjct: 114 ---NDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGRE----------DKSDQSDDEKIQ 160
Query: 652 ---DEKGLEAADK-KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
DE+ + +D+ K + D DEK+ D++ + +D + + ++E+ DD
Sbjct: 161 NSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVAS 220
Query: 708 DEEEDSSEKLFDDSDERGTLGG----FGSVEEGPLSTGSSFILSSDDDDDD 754
D ++ EK D +E+ L S +E P ++ S D+++ D
Sbjct: 221 DNDD---EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQD 268
Score = 65.9 bits (159), Expect = 1e-10
Identities = 84/376 (22%), Positives = 149/376 (39%), Gaps = 49/376 (13%)
Query: 370 EAFLNAPEANRGLRRSDSVSASERA-GPSRARHFSEHPSTSKMNAQETATGMAFEEPIDE 428
E F + E S S + SER+ S A S+H + + + E P D+
Sbjct: 60 ELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---EAPNDD 116
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
+ DGG A + S EK E ++ +E + S++
Sbjct: 117 EDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKI-----------QNSDDE 165
Query: 489 NPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKES 548
+GS+ED + + ++N +E + S+D+ + SEEE K + +D+ S
Sbjct: 166 ERAQGSDEDKLQNSDDDEKMQNTDDEER-PQLSDDERQQLSEEE----KANSDDERPVAS 220
Query: 549 DEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK--ELHENVLDKELEENDSENSEFEDDG 606
D D ++ S+D + + + ++ D+E + E H + D+E +++ SE++ D
Sbjct: 221 DNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSE 280
Query: 607 SE----KVLDEEGSEREFDEDSDEKEEEEDTYEKV--FDDESDEKEDEEY-------ADE 653
E K + S+ E D D++ ++ T + DD S + E+ DE
Sbjct: 281 DEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 340
Query: 654 KGLEAADKKAEEGDADEKLFEESDDKEDEDADGK------------EVEDADEKLFEDDD 701
GL + EE E E K + D E D + +ED+
Sbjct: 341 NGLP--QDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEF 398
Query: 702 SNEKLFDEEEDSSEKL 717
+E++ DEE + KL
Sbjct: 399 EDEEMLDEEGRTRLKL 414
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/360 (18%), Positives = 136/360 (37%), Gaps = 24/360 (6%)
Query: 357 ETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQET 416
++ ER++ G ++ + A G S S S + G S PS ++ ++
Sbjct: 13 DSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSG------QPSNKELFGDDS 66
Query: 417 ATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGF 476
A + E++++ E E + + S ++ + P + +EG G
Sbjct: 67 EDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGG 126
Query: 477 EGSCSQKESEEGNP--VRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVG 534
+ SE+ + + ED + +K +D EE + + N + +E++
Sbjct: 127 SHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM- 185
Query: 535 PTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEE 594
++ +D+ + +D ++ SE+ +E + D D+E + E + +
Sbjct: 186 ---QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEE-----QPQL 237
Query: 595 NDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDE-SDEKEDEEYADE 653
+D E + DD + DEE R D++ ++ + E +DE K A +
Sbjct: 238 SDEEKMQNSDDERPQASDEE--HRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
Query: 654 KGLEAADKKAEEGDADEKLFEESDD----KEDEDADGKEVEDADEKLFEDDDSNEKLFDE 709
++ + ++ LF +DD + ED + DE D E+ E
Sbjct: 296 SEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPE 355
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/339 (20%), Positives = 133/339 (39%), Gaps = 49/339 (14%)
Query: 401 HFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFE--EGASENNAKESSPEKEA 458
H SE + K ++ + G E+ D+ EK ++ + E +G+ E+ + S +++
Sbjct: 128 HHSEAEGSEKAHSDDEKWGR--EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKM 185
Query: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
+ E+ + +R + S++ PV +D + ++ + EE
Sbjct: 186 QNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK--M 243
Query: 519 KESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEG 578
+ S+D+ + S+EE + + EE D + ES SED R +N + D + +
Sbjct: 244 QNSDDERPQASDEEHRHSDDEEEQDHKSESARG---SDSEDEVLRMKRKNAIASDSEADS 300
Query: 579 SEKELHENVLDKEL---EENDSENSEFEDDGSE--KVLDEEGSEREFDEDSDEKEEE--- 630
+ +N +L ++ S S+ ED + +DE G ++ E+ E
Sbjct: 301 DTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEV 360
Query: 631 ----------EDTY-----------EKVFDDE--SDEKEDEEYADEKGLEAADKKAEEGD 667
D Y + FD + DE EDEE DE+G K E
Sbjct: 361 EIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVE--- 417
Query: 668 ADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKL 706
+ D +G E+++++ ++ + D + L
Sbjct: 418 ------NTIRWRIRRDEEGNEIKESNARIVKWSDGSMSL 450
Score = 36.6 bits (83), Expect = 0.088
Identities = 42/174 (24%), Positives = 71/174 (40%), Gaps = 25/174 (14%)
Query: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTK-- 537
CS+ + P+ G + + + E KK + + + +ES+ +E + + G +
Sbjct: 512 CSKTQKIRILPMAGRDPECQRTEMIKK--EEERLRASIRRESQQRRMREKQHQRGLSASY 569
Query: 538 -ESEEDDSEKESDEDCSE---KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELE 593
E + D E+E +E S K G RE D DE GSE++ + +L +
Sbjct: 570 LEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDE-GSEEDKAQRLLKAKKL 628
Query: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKED 647
+D E E G K ED D+ ++ Y V DE +E +D
Sbjct: 629 TSDEEG---EPSGKRKA-----------EDDDKANKKHKKY--VISDEEEEDDD 666
Score = 35.4 bits (80), Expect = 0.20
Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 5/101 (4%)
Query: 448 NAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE--EGNPVRGSEEDSPKK--ES 503
+A P++ EE E+ K ++G ++ + + GSEED ++ ++
Sbjct: 566 SASYLEPDRYDEEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKA 625
Query: 504 KKKTLKNDCEENGLAKESEDD-LNKESEEEVGPTKESEEDD 543
KK T + E +G K +DD NK+ ++ V +E E+DD
Sbjct: 626 KKLTSDEEGEPSGKRKAEDDDKANKKHKKYVISDEEEEDDD 666
Score = 34.7 bits (78), Expect = 0.34
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 23/134 (17%)
Query: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSEF--EDDGSEKVL-----------D 612
EE L + E ++ + E + L + E + E++G E +
Sbjct: 539 EEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGGI 598
Query: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672
E R + DSDE EE+ + K + +DE+G + +KAE+ D K
Sbjct: 599 REERARIYSSDSDEGSEEDKAQRLL-------KAKKLTSDEEGEPSGKRKAEDDDKANKK 651
Query: 673 FEE---SDDKEDED 683
++ SD++E++D
Sbjct: 652 HKKYVISDEEEEDD 665
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 79.0 bits (193), Expect = 2e-14
Identities = 90/356 (25%), Positives = 153/356 (42%), Gaps = 61/356 (17%)
Query: 438 GEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEED 497
GE + S+ E E ++G EK+ E+ K +G + E E G D
Sbjct: 4683 GEGMKDVSDQIGNEEQVEDTFQKG-QEKDKEDPDSKSDIKGEDNAIEMSED--FDGKMHD 4739
Query: 498 SPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQS 557
+E ++ K+D E L K DLN E +++ ++D+ E E +ED +++
Sbjct: 4740 GELEEQEEDDEKSDSEGGDLDKHM-GDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEET 4798
Query: 558 EDGSEREFEENGLEKD-LDEEGSEKELHENVLDKELEENDSENSEFEDDGS--EKVLDEE 614
G + E E + D LD S K+ + DK+ E+ ++E DDG E ++E+
Sbjct: 4799 GPGMDEEDSELVAKDDNLDSGNSNKDKSQQ--DKKEEKEEAE----ADDGGQGEDKINEQ 4852
Query: 615 GSEREFDE---------------------------DSDEKEEEEDTYEKVFDDESDEKED 647
ER++DE DS++K EDT D+E E+E+
Sbjct: 4853 IDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDT-----DNEEGEEEN 4907
Query: 648 ----EEYADEKGLEAADKKAEEGDADEKLFEESDDK---EDEDADGKEVED--ADEKLFE 698
+E +E G EA ++ E D +E + ++ ED+ A+G+E D AD++ +
Sbjct: 4908 PLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGD 4967
Query: 699 DDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
E+ +E++ S E+ ++DE G E GP G + +D D
Sbjct: 4968 AAQHPEEHSEEQQQSVEEKDKEADEEGG-------ENGPADQGFQPQEEEEREDSD 5016
Score = 67.8 bits (164), Expect = 4e-11
Identities = 86/352 (24%), Positives = 155/352 (44%), Gaps = 59/352 (16%)
Query: 384 RSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEG 443
+ D S S+ G A SE KM+ E + +E DEK +GG+ ++
Sbjct: 4711 KEDPDSKSDIKGEDNAIEMSED-FDGKMHDGE----LEEQEEDDEKS---DSEGGDLDKH 4762
Query: 444 ASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSP--KK 501
+ N +E+ E G ++E +E EE N +EE P +
Sbjct: 4763 MGDLNGEEADKLDERLWGDDDEEEDE---------------EEEDNK---TEETGPGMDE 4804
Query: 502 ESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGS 561
E + K+D ++G + + + +K+ E+E E+E DD + D K +E
Sbjct: 4805 EDSELVAKDDNLDSGNSNKDKSQQDKKEEKE-----EAEADDGGQGED-----KINEQID 4854
Query: 562 EREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFED-DGSEKVLDEEGSE--- 617
ER+++EN ++ G+++++ E + L+ D N + ED +G E +EEG E
Sbjct: 4855 ERDYDENEVD---PYHGNQEKVPE---PEALDLPDDLNLDSEDKNGGEDTDNEEGEEENP 4908
Query: 618 ---REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADE----KGLEAADKKAEEGDADE 670
+E E++ + EE E ++ +E EE E +G E D A++ D D
Sbjct: 4909 LEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDA 4968
Query: 671 KLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
E +E + + ++ ++ADE+ E+ +++ +EE+ E DSD
Sbjct: 4969 AQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE----DSD 5016
Score = 66.2 bits (160), Expect = 1e-10
Identities = 94/444 (21%), Positives = 169/444 (38%), Gaps = 54/444 (12%)
Query: 348 DGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPS 407
D +D + E+ + E E G E +SDS G +H +
Sbjct: 4715 DSKSDIKGEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDS------EGGDLDKHMGDLNG 4768
Query: 408 TSKMNAQETATGMAFEEPIDEKKFEKTEDGG------EFEEGASENNAKESSPEKEAEEG 461
E G EE +E++ KTE+ G + E A ++N + K+ +
Sbjct: 4769 EEADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQ 4828
Query: 462 CPEKESEEGCPKRGFEGSCSQKES--------EEGNPVRGSEEDSPKKESKKKTLKNDCE 513
++E EE G +G E E +P G++E P+ E+ L +D
Sbjct: 4829 DKKEEKEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALD--LPDDLN 4886
Query: 514 ENGLAKESEDDLNKESEEEVGPTK----------------ESEEDDSEKESDEDCSEKQS 557
+ K +D + E EE P + E+E D +E +S ++ E S
Sbjct: 4887 LDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPS 4946
Query: 558 EDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEG-- 615
ED EE D D++G + E +++ + + ++ E +++G E ++G
Sbjct: 4947 EDDKAEGEEEMDTGAD-DQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQ 5005
Query: 616 -SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFE 674
E E EDSD +E+ + E+ + E + + +E A E+ E+
Sbjct: 5006 PQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEE--H 5063
Query: 675 ESDDKEDEDADGKE----VEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDER-----G 725
S + A+G E + A +K + + K + D +E+ D +ER
Sbjct: 5064 GSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQAD-NERSMGDHNERVHKRLR 5122
Query: 726 TLGGFGSVEEGPLSTGSSFILSSD 749
T+ E+GP + + +D
Sbjct: 5123 TVDTDSHAEQGPAQQPQAQVEDAD 5146
Score = 60.5 bits (145), Expect = 6e-09
Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 8/281 (2%)
Query: 477 EGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPT 536
EG+ + E G G + + D + G K+ ED +K +
Sbjct: 4667 EGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNA 4726
Query: 537 KESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEK---DLDEEGSEKELHENVLDKELE 593
E ED K D + E+Q ED + + E L+K DL+ E ++K L E + + E
Sbjct: 4727 IEMSEDFDGKMHDGEL-EEQEEDDEKSDSEGGDLDKHMGDLNGEEADK-LDERLWGDDDE 4784
Query: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADE 653
E D E + + + + +DEE SE +D+ + +K D+ +EKE+ E D
Sbjct: 4785 EEDEEEEDNKTEETGPGMDEEDSELVAKDDN--LDSGNSNKDKSQQDKKEEKEEAEADDG 4842
Query: 654 -KGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEED 712
+G + +++ +E D DE + +++ + + ++ D+ + +D N + E+
Sbjct: 4843 GQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEE 4902
Query: 713 SSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDD 753
E+ + E+ G + E G T + S + ++
Sbjct: 4903 GEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEE 4943
Score = 56.2 bits (134), Expect = 1e-07
Identities = 56/252 (22%), Positives = 117/252 (46%), Gaps = 41/252 (16%)
Query: 477 EGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPT 536
+G C KE E + G+ E +D E G+ E + K+ +++G
Sbjct: 4652 KGFCLPKEFMEDSAGEGATEF------------HDYEGGGIG---EGEGMKDVSDQIG-N 4695
Query: 537 KESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEND 596
+E ED +K ++D + S+ S+ + E+N +E D +G ++H+ L+++ E+++
Sbjct: 4696 EEQVEDTFQKGQEKDKEDPDSK--SDIKGEDNAIEMSEDFDG---KMHDGELEEQEEDDE 4750
Query: 597 SENSEFED----------DGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKE 646
+SE D + ++K+ + + + +ED +E ED + DE++
Sbjct: 4751 KSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEE----EDNKTEETGPGMDEED 4806
Query: 647 DEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDA-DGKEVEDADEKLFEDDDSNEK 705
E A + L++ + ++ D+K ++KE+ +A DG + ED + ++ D +E
Sbjct: 4807 SELVAKDDNLDSGNSNKDKSQQDKK-----EEKEEAEADDGGQGEDKINEQIDERDYDEN 4861
Query: 706 LFDEEEDSSEKL 717
D + EK+
Sbjct: 4862 EVDPYHGNQEKV 4873
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/335 (20%), Positives = 136/335 (40%), Gaps = 55/335 (16%)
Query: 396 PSRARHFSEHPSTSKMNAQETATGMAFEE-PIDEKKFEKTED---GGEFEEGASENNAKE 451
P A H +E ++ + E+ + EE P ++ K E E+ G + ++G + + +E
Sbjct: 4915 PEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEE 4974
Query: 452 SSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKND 511
S E++ +KE++E + G Q + EE +EE P+ +K+
Sbjct: 4975 HSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHAS-- 5032
Query: 512 CEENGLAKESEDDLNKESEEEVGPTKESEEDDSE-------------------------- 545
C + G+ E+ N ++ E G E E+ E
Sbjct: 5033 CGQTGV----ENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQK 5088
Query: 546 --KESDEDCSEKQSEDGSEREFEENGLEK-------DLD---EEGSEKELHENVLDKELE 593
+++ + K + +ER ++ D D E+G ++ V D +
Sbjct: 5089 HTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAF 5148
Query: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADE 653
E+ + S+ D + V +E +++ +DS + +EEE+ + + D E E+E+ + AD
Sbjct: 5149 EHIKQGSDAYDAQTYDVASKE--QQQSAKDSGKDQEEEEIEDTLMDTE--EQEEFKAADV 5204
Query: 654 KGLEAADKKAEEG---DADEKLFEESDDKEDEDAD 685
+ L+ + K+ DE E K +ED D
Sbjct: 5205 EQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQD 5239
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 78.6 bits (192), Expect = 2e-14
Identities = 91/358 (25%), Positives = 152/358 (42%), Gaps = 31/358 (8%)
Query: 373 LNAPEANRGLR-RSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKF 431
+ APEA + S+ V A E G ++ P + + A E A G A E D +
Sbjct: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE-AEGEAQPESEDVETP 1893
Query: 432 EKTEDGGEFEEGASENNA-KESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNP 490
E + EGA A KE+ PE E+ E E E E+ G E +E+EE
Sbjct: 1894 EAEWEVQPESEGAEAPEAEKEAQPETESVEAL-ETEGEDEPESEGAEA----QEAEEA-- 1946
Query: 491 VRGSEEDSPKKESKKKTLKNDCEENGLAKESED----DLNKESEEEVGPTKESEEDDSEK 546
++E + + + + +++ E ESED ++ E++E G + ED
Sbjct: 1947 ---AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAP 2003
Query: 547 ESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK-----ELHENVLDKELEENDSENSE 601
E++ + E + E + E +G+E EG E E + D + E + E E
Sbjct: 2004 EAEGEMQEAEEE----AQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
Query: 602 FEDDGSE---KVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEA 658
E++ E +V + EG ED D +E E + + E+ E E E E G+EA
Sbjct: 2060 AEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE-GIEA 2118
Query: 659 ADKKAEEGDADEKL-FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
+ + E E + E++ + +++G E +DA+ + + + E EEE E
Sbjct: 2119 PETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176
Score = 77.4 bits (189), Expect = 5e-14
Identities = 94/378 (24%), Positives = 156/378 (41%), Gaps = 25/378 (6%)
Query: 377 EANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKK--FEKT 434
E ++ L R E G + A+ K + ET+ G E E + E+
Sbjct: 1747 EGSQRLNRDKDPKLGEAEGDAMAQE-----REGKTHNSETSAGSELGEAEQEGEGISERG 1801
Query: 435 EDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGS 494
E GG+ G +N E++ + + G + + EG EG +Q ESE G +
Sbjct: 1802 ETGGQ-GSGHEDNLQGEAAAGGDQDPG--QSDGAEGIEAPEAEGE-AQPESE-GVEAPEA 1856
Query: 495 EEDSPKKESKKKTLKNDCE----ENGLAKESEDDLNKESEEEVGPTKE-SEEDDSEKESD 549
E D+ + E + + D E E ESED E+E EV P E +E ++EKE+
Sbjct: 1857 EGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQ 1916
Query: 550 EDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK 609
E +S + E E E+ + + + +E+ E + E E+ E E++ +
Sbjct: 1917 ---PETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPE 1973
Query: 610 VLDEEGSEREFDEDSDEKE---EEEDTYEKVFDDESDEKEDEEYADEKGLEAADK-KAEE 665
D E E E + E E E ED + E E E+E + G+EA K + EE
Sbjct: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033
Query: 666 GDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERG 725
E ++++ ++DG E +A+E+ E + ++ E SE + D + G
Sbjct: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV-DAQEAEG 2092
Query: 726 TLGGFGSVEEGPLSTGSS 743
E P + G +
Sbjct: 2093 EAQPESEGVEAPEAEGEA 2110
Score = 67.8 bits (164), Expect = 4e-11
Identities = 80/361 (22%), Positives = 139/361 (38%), Gaps = 27/361 (7%)
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA 413
+ E +E + EA E +++ A E A + + E A
Sbjct: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
Query: 414 QETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA--EEGCPEKESEEGC 471
+E A + + E + E E GE + + + A E+ E + EE PE + E
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ 2026
Query: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEE 531
PK EG +Q+ E G + + + E G +E+E + + ESE+
Sbjct: 2027 PKS--EGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
Query: 532 EVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKE 591
+++E + E + + + E +G ++ E G+E + EG + E + E
Sbjct: 2085 -----VDAQEAEGEAQPESEGVEAPEAEGEAQKAE--GIEAP-ETEGEAQPESEGIEAPE 2136
Query: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
E SE + D EG + E + +E EE+ ++ E+ E E E
Sbjct: 2137 AEGEAQPESE-----GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQP 2191
Query: 652 DEKGLEAADKKAEEGDADEKL-------FEESDDKEDEDADGKEVEDADEKLFEDDDSNE 704
+ +G+EA + EG+A +L EE E E + E E + E + E
Sbjct: 2192 ESEGIEAPE---AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGE 2248
Query: 705 K 705
K
Sbjct: 2249 K 2249
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/356 (23%), Positives = 144/356 (40%), Gaps = 36/356 (10%)
Query: 348 DGTTDYQVEETSREREERLRGWEAFLNAPEANRGLR-RSDSVSASERAGPSRARHFSEHP 406
+G + EE ++E E + + + + EA + S+ V A E ++ P
Sbjct: 1936 EGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQP 1995
Query: 407 STSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKE 466
+ + A E A G E E++ + DG E + + A+E E + EG + E
Sbjct: 1996 ESEDVEAPE-AEGEMQEA---EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
Query: 467 SEEGCPKRGFEGSCSQKESEE--GNPVRGSEEDSPKKE---SKKKTLKNDCEENGL-AKE 520
S+ G E +++E++E G E P+ E +++ + E G+ A E
Sbjct: 2052 SD------GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE 2105
Query: 521 SEDDLNK-------ESEEEVGPTK---ESEEDDSEKESDEDCSEKQSEDGSEREFEENGL 570
+E + K E+E E P E+ E + E + + + E Q +G E + E G+
Sbjct: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEG-EAQPESEGI 2164
Query: 571 EKDLDEEGSEKELHENVLDKELE---ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEK 627
E EE ++ EL E V E E + +SE E + E + EG E E+ +
Sbjct: 2165 EAQEAEEEAQPEL-EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP 2223
Query: 628 EEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED 683
E E + + E E E ++KG + GD + ES ED
Sbjct: 2224 EPEGVETPEAEGEAQPESEGETQGEKKG----SPQVSLGDGQSEEASESSSPVPED 2275
Score = 50.1 bits (118), Expect = 8e-06
Identities = 52/158 (32%), Positives = 73/158 (46%), Gaps = 19/158 (12%)
Query: 423 EEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQ 482
EE + ++ ++TE G+ EE A +E+ E EEG +E +EG P+ G +G +
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG-PEGGLQGEALE 1391
Query: 483 KE-SEEGNPVRG-------SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVG 534
+ EEG P G SE SP + ++ EE G A S + E EE
Sbjct: 1392 EGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEE-- 1449
Query: 535 PTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEK 572
PT E E+D SE+QS GS+ E GLEK
Sbjct: 1450 PT---EPPSHLSETDPSASERQS--GSQL---EPGLEK 1479
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/182 (23%), Positives = 81/182 (44%), Gaps = 12/182 (6%)
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSERE--------FEENGLEK 572
+ED+ ++SEE+ + E +E E+ +++++G+E E EE E+
Sbjct: 1272 NEDEAERDSEEQ--RASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEE 1329
Query: 573 DLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEED 632
L EEG + E + + +E +++ E E+ G E L EEG + E ++ E + +
Sbjct: 1330 GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEG-LQEEGVQLEEVKEGPEGGLQGE 1388
Query: 633 TYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDA 692
E+ +E +E + E EA+ + D+ + EE + A+ E
Sbjct: 1389 ALEEGLKEEGLPEEGSVHGQELS-EASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGT 1447
Query: 693 DE 694
+E
Sbjct: 1448 EE 1449
Score = 47.4 bits (111), Expect = 5e-05
Identities = 41/182 (22%), Positives = 81/182 (44%), Gaps = 8/182 (4%)
Query: 552 CSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN------DSENSEFEDD 605
C+ +ED +ER+ EE +L E+ +E + E V +E +E E + E+
Sbjct: 1267 CACATNEDEAERDSEEQRASSNL-EQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEET 1325
Query: 606 GSEKVLDEEGSE-REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAE 664
+E+ L EEG + E E E ++EE+ + ++ E EE + ++ +
Sbjct: 1326 KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL 1385
Query: 665 EGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDER 724
+G+A E+ +E E+ G+E+ +A + ++ + +EE + +
Sbjct: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAE 1445
Query: 725 GT 726
GT
Sbjct: 1446 GT 1447
Score = 46.6 bits (109), Expect = 9e-05
Identities = 55/252 (21%), Positives = 96/252 (38%), Gaps = 21/252 (8%)
Query: 454 PEKEAEEGCPEKESEEGCPKRGFEGS----CSQKESEEGNPVRGSEEDSPKKESKKKTLK 509
P+ E + E+++ C F + C+ E E R SEE ++
Sbjct: 1239 PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAE---RDSEEQRASSNLEQLAEN 1295
Query: 510 NDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENG 569
EE L + E + +EE +E++ ++ +E E + +G ++ EE
Sbjct: 1296 TVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQ 1355
Query: 570 LEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEE 629
LE +++E G E E V +E++E + + E+ L EEG E E E
Sbjct: 1356 LE-EIEETGGEGLQEEGVQLEEVKE--GPEGGLQGEALEEGLKEEGLPEEGSVHGQELSE 1412
Query: 630 EEDTYEKVFDDESDEKEDEEYADEKGLEAADKK------AEEGDADEKLFEESDDKEDED 683
D + +++D +E G +A + EE E+D E
Sbjct: 1413 ASSP-----DGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASER 1467
Query: 684 ADGKEVEDADEK 695
G ++E EK
Sbjct: 1468 QSGSQLEPGLEK 1479
Score = 42.7 bits (99), Expect = 0.001
Identities = 54/213 (25%), Positives = 92/213 (43%), Gaps = 30/213 (14%)
Query: 514 ENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSE---REFEENGL 570
+ G E LN++ + ++G E+E D +E + ++ GSE E E G+
Sbjct: 1741 DEGEDGEGSQRLNRDKDPKLG---EAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGI 1797
Query: 571 EKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEE 630
+ E G + HE+ L E ++ + DG+E + E +E E +S+ E
Sbjct: 1798 S-ERGETGGQGSGHEDNLQGEAAAGGDQDPG-QSDGAEGIEAPE-AEGEAQPESEGVEAP 1854
Query: 631 EDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDA------ 684
E E D +E E A E+ D +A E + + + ES+D E +A
Sbjct: 1855 EA--------EGDAQEAEGEAQP---ESEDVEAPEAEGEAQ--PESEDVETPEAEWEVQP 1901
Query: 685 --DGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
+G E +A+++ + +S E L E ED E
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPE 1934
Score = 32.0 bits (71), Expect = 2.2
Identities = 43/228 (18%), Positives = 83/228 (36%), Gaps = 8/228 (3%)
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA 413
+ ++ E + G EA EA L + V A E G ++ ++ A
Sbjct: 2149 EAQDAEGEAQPESEGIEAQEAEEEAQPEL---EGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
Query: 414 QETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPK 473
Q G+ E P E++ + +G E E E + + ++G P+ +G +
Sbjct: 2206 QPELEGV--EAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSE 2263
Query: 474 RGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEV 533
E S S + P D+P + +T + + + D E++ +
Sbjct: 2264 EASESS-SPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD--SENDHVL 2320
Query: 534 GPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEK 581
G T+ + + E + + + S E EE L E+G+ +
Sbjct: 2321 GDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASE 2368
Score = 31.6 bits (70), Expect = 2.8
Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 14/93 (15%)
Query: 408 TSKMNAQETATGMAFEEP---IDEKKFEKTEDGGEF------EEGAS-ENNAKESSPEKE 457
++++ A+ A G E+P ID E GG EEGAS +++A S E
Sbjct: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGS 545
Query: 458 AEEGCPEKESEEGCPKRGFEGSCSQKESEEGNP 490
+E G +GCP + + Q+ SE G+P
Sbjct: 546 SEWG----GRPQGCPGKARAETSQQEASEGGDP 574
Score = 30.8 bits (68), Expect = 4.9
Identities = 31/124 (25%), Positives = 49/124 (39%), Gaps = 27/124 (21%)
Query: 616 SEREFDEDSDEKEEE---EDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672
+E E + DS+E+ E E +E +E +E + +GL+ + EE +E L
Sbjct: 1272 NEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 673 FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGS 732
EE G ++E+ E E E +E E++ GG G
Sbjct: 1332 QEE----------GVQLEETKETEGEGQQEEEAQLEEIEET--------------GGEGL 1367
Query: 733 VEEG 736
EEG
Sbjct: 1368 QEEG 1371
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 78.2 bits (191), Expect = 3e-14
Identities = 80/363 (22%), Positives = 158/363 (43%), Gaps = 45/363 (12%)
Query: 389 SASERAGPSRARHFSEHPSTSKMNAQE-----TATGMAFEEPIDEKKFEKTEDGGEFEEG 443
S+ + +G S AR + ++ +N Q + + +A P + D EE
Sbjct: 28 SSDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQASSVVVIDSDSDEEC 87
Query: 444 ASENNAK----ESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSP 499
+ K E + + E+ E C K + + P S + + GN + +++S
Sbjct: 88 HTHEEKKAKLLEINSDDESPECCHVKPAIQEPP---IVISDDDNDDDNGNDLEVPDDNSD 144
Query: 500 KKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEE-DDSEKESD--EDCSEKQ 556
E+ ++N E+ DD + +SE + +SE DD+ +SD +D S+
Sbjct: 145 DSEAP--------DDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDS 196
Query: 557 SEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSE--KVLDEE 614
S+D S+ ++N + D+ ++ S+ D ++ ++ S++S+ DD S+ + D+
Sbjct: 197 SDDNSDDSSDDNSDDSDVPDDKSD--------DSDVPDDSSDDSDVPDDSSDDSEAPDDS 248
Query: 615 GSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKG--LEAADKKAEEGDADEKL 672
+ E +DS + E D + D +D E +D+ EA+D +++ +A +
Sbjct: 249 SDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDK 308
Query: 673 FEESDDKEDEDADGKEVEDADEKL-----FEDDDSNEKLFDEEEDSSE-----KLFDDSD 722
++SD ED+ D +D + L ED + ++ +EE+ E D SD
Sbjct: 309 SDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSSD 368
Query: 723 ERG 725
+ G
Sbjct: 369 DAG 371
Score = 72.4 bits (176), Expect = 1e-12
Identities = 62/244 (25%), Positives = 109/244 (44%), Gaps = 26/244 (10%)
Query: 525 LNKESEEEVGPTKESE----EDDSEKESDEDCSEKQS--------EDGSEREFEENGLEK 572
++ +S+EE +E + E +S+ ES E C K + D + N LE
Sbjct: 79 IDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNGNDLEV 138
Query: 573 DLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEED 632
D + +N D E +++S++SE DD S+ D E D++SD+ + +D
Sbjct: 139 PDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSD---DSEAP----DDNSDDSDVPDD 191
Query: 633 TYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDA 692
+ DD SD+ D+ D + D K+++ D + ++SD +D D + +D+
Sbjct: 192 NSDDSSDDNSDDSSDDNSDDS---DVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDS 248
Query: 693 DEKLFEDDDSNE--KLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDD 750
+ DDS++ + D+ D SE D SD+ + S ++ S SS + D
Sbjct: 249 SDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDD--SEASDDSSDDSEASDDSSDDSEAPD 306
Query: 751 DDDD 754
D D
Sbjct: 307 DKSD 310
Score = 63.9 bits (154), Expect = 5e-10
Identities = 61/296 (20%), Positives = 123/296 (41%), Gaps = 18/296 (6%)
Query: 423 EEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEG-CPEKESEEG-CPKRGFEGSC 480
E PI + +D G E +N+ +P+ +++ P+ S++ P + S
Sbjct: 118 EPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSE 177
Query: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLN-KESEEEVGPTKES 539
+ ++ + + V D ++ + ++ +++ + + DD + + + +
Sbjct: 178 APDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDD 237
Query: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
DDSE D + +D S+ E D + ++ D E ++ S++
Sbjct: 238 SSDDSEAPDDSSDDSEAPDDSSDDS------EAPDDSSDDSEAPDDSSDDSEASDDSSDD 291
Query: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKE----DEEYADEKG 655
SE DD S+ D E + + D DSD E++ D + V DD SD+ E E+ +E
Sbjct: 292 SEASDDSSD---DSEAPDDKSD-DSDVPEDKSDDSD-VPDDNSDDLEVPVPAEDLCNEGQ 346
Query: 656 LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEE 711
+ + +++ E A + SDD ++D + + + S KL EEE
Sbjct: 347 IASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEE 402
Score = 59.7 bits (143), Expect = 1e-08
Identities = 49/260 (18%), Positives = 104/260 (40%), Gaps = 8/260 (3%)
Query: 432 EKTEDGGEFEEGASENNAKESSPEKEAEEG-CPEKESEEGCPKRGFEGSCSQKESEEGNP 490
E +D + E +N+ +P+ +++ P+ S++ + S + +
Sbjct: 157 EAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPD 216
Query: 491 VRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDE 550
+ + D P S + +D ++ E+ DD + +SE + +SE D + D
Sbjct: 217 DKSDDSDVPDDSSDDSDVPDDSSDDS---EAPDDSSDDSEAPDDSSDDSEAPDDSSD-DS 272
Query: 551 DCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKV 610
+ + S+D + + E D + + D ++ E+ S++S+ DD S+ +
Sbjct: 273 EAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDL 332
Query: 611 ---LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGD 667
+ E E SDE+E E D SD+ +++ + +D +A
Sbjct: 333 EVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEV 392
Query: 668 ADEKLFEESDDKEDEDADGK 687
++ KL E + + GK
Sbjct: 393 SERKLPTEEEPAPVVEQSGK 412
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/266 (18%), Positives = 106/266 (39%), Gaps = 15/266 (5%)
Query: 373 LNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFE 432
L P+ N + ++ + P SE P + +++ + D+ +
Sbjct: 136 LEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNSDD 195
Query: 433 KTEDGGEFEEGASENNAKESS--PEKEAEEGCPEKESEEG-CPKRGFEGSCSQKESEEGN 489
++D + +S++N+ +S +K + P+ S++ P + S + +S + +
Sbjct: 196 SSDDNSD---DSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDS 252
Query: 490 PVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESD 549
D + +++ E+ DD + +SE + +SE D +K D
Sbjct: 253 EAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPD-DKSDD 311
Query: 550 EDCSEKQSEDGSEREFEENGLE-----KDLDEEGSEKELHENVLDKELEENDSENSEFED 604
D E +S+D + + LE +DL EG E +++ + ++S D
Sbjct: 312 SDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSS---D 368
Query: 605 DGSEKVLDEEGSEREFDEDSDEKEEE 630
D E+ L E S+ D +++ + E
Sbjct: 369 DAGEQDLGENLSKPPSDPEANPEVSE 394
Score = 37.0 bits (84), Expect = 0.068
Identities = 48/224 (21%), Positives = 91/224 (40%), Gaps = 25/224 (11%)
Query: 545 EKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFED 604
E E DEDC + S+ + + + K +L+ + D+ S
Sbjct: 13 EPEEDEDCYILNVQSSSDDTSGSSVARR------APKRQASCILNVQSRSGDTSGSSVAR 66
Query: 605 DGSEKVLDEEGSEREFDEDSDEK-EEEEDTYEKVFDDESDEKEDEEYADEKGLEAA---- 659
++ + S D DSDE+ E+ K+ + SD++ E + ++
Sbjct: 67 RAPKR---QASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVI 123
Query: 660 ---DKKAEEGDADEKLFEESDDKE--DEDADGKEVED--ADEKLFEDDDSNE-KLFDEEE 711
D + G+ E + SDD E D+++D E D +D+ DD+S++ + D+
Sbjct: 124 SDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNS 183
Query: 712 DSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI 755
D S+ D+SD+ S ++ ++ S + DD D+
Sbjct: 184 DDSDVPDDNSDDSSDDNSDDSSDD---NSDDSDVPDDKSDDSDV 224
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 76.6 bits (187), Expect = 8e-14
Identities = 126/626 (20%), Positives = 232/626 (37%), Gaps = 110/626 (17%)
Query: 118 RKAESGWFHVEEDRN----TNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLY 173
RK G E D N T V+V + + QL++K G+++ K
Sbjct: 68 RKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVL--------SWKRV 119
Query: 174 KDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKC 233
+ G L+ G C Y + ES AL+LL + +I KL V+V
Sbjct: 120 QGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKV------------------ 161
Query: 234 KDYKKKLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRV 293
D K K + + W+ +++A R E V N+ E L
Sbjct: 162 -DAKTKAQLDE----WKAKKKASNGNARPETVT------------------NDDEEALDE 198
Query: 294 ECSKFGQIRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDY 353
E + Q+ K G V R+ ++ A + + +D
Sbjct: 199 ETKRRDQMIK---------GAIEVLIREYSS----------------ELNAPSQE--SDS 231
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSR---ARHFSEHPSTSK 410
+ +E++E + + F AP L + ++A E R +R S+ T K
Sbjct: 232 HPRKKKKEKKEDI--FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHK 289
Query: 411 MNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEG 470
+E + I++++ E+ + E +E E+E E+ + +
Sbjct: 290 KLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
Query: 471 CPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESE 530
R E + + + R D K S+ + D E +E E + +E E
Sbjct: 350 DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERE---RERERERERERE 406
Query: 531 EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDK 590
E +E E + + E ++ E+ E +E LE+ L E+ E E + +
Sbjct: 407 REREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREK--EAAYQERLKNW 464
Query: 591 ELEENDS-----ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTY----------- 634
E+ E + +E E++ ++ E +EF ED D+ ++ Y
Sbjct: 465 EIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRD 524
Query: 635 -EKVFD-DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD--KEDEDADGKEVE 690
EK + DE D K ++E +E + + DA+ + E+ + ++ + E E
Sbjct: 525 REKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESE 584
Query: 691 DADEKLFEDDDSNEKLFDEEEDSSEK 716
+ +E+ E ++ E+ +EEE+ +K
Sbjct: 585 EEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 73.2 bits (178), Expect = 9e-13
Identities = 73/322 (22%), Positives = 139/322 (43%), Gaps = 33/322 (10%)
Query: 430 KFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGN 489
KF T E E+G E +E EKE E E+E E +R E ++ +E
Sbjct: 283 KFRDTHKKLEEEKGKKEKERQEI--EKERRERERERERERERREREREREREREREKEKE 340
Query: 490 PVRGSEEDSPKKESKKKTLKNDCE-ENGLAKESEDDLNKESEEEVGPTKESEEDDSEKES 548
R E D + +K++ D E + +E D NK+ +++ E + +
Sbjct: 341 RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE 400
Query: 549 DEDCSEKQSEDGSEREFE-----ENGLEKDLDEEGSEKELHE-NVLDKELEENDSENSEF 602
E E++ E ERE E E +K D E E++ +E L+++L E + + +
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKE---AAY 457
Query: 603 EDDGSEKVLDEEGSEREFDEDSDEKEE-------EEDTYEKVFDDESDEKEDEEY----A 651
++ + E RE++++++ +EE E ++ +D D+++D +Y A
Sbjct: 458 QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517
Query: 652 DEKGLEAADKKAEEGDADEKLFEE----------SDDKEDEDADGKEVEDADEKLFEDDD 701
+K L +K+ E + D K +E ++ D DA+ + +E E+ +
Sbjct: 518 LQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQI 577
Query: 702 SNEKLFDEEEDSSEKLFDDSDE 723
E +EEE+ ++ + +E
Sbjct: 578 KQEPESEEEEEEKQEKEEKREE 599
Score = 64.3 bits (155), Expect = 4e-10
Identities = 62/302 (20%), Positives = 122/302 (40%), Gaps = 30/302 (9%)
Query: 436 DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSE 495
D + ++ AS NA+ + + EE E+ +G ++ S E N
Sbjct: 170 DEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQES 229
Query: 496 EDSPKKESKKKT------------------LKNDCEENGLAKESEDDLNKESEEEVGPTK 537
+ P+K+ K+K K D + ++ D +++E + K
Sbjct: 230 DSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHK 289
Query: 538 ESEEDDSEKESDEDCSEKQSEDGS-EREFEENGLEKDLDEEGSEKELHENVLDKELE-EN 595
+ EE+ +KE + EK+ + ERE E E++ + E + E ++E E +
Sbjct: 290 KLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
Query: 596 DSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKG 655
D + ++ D ++ E +R+ + SD ++ + EK D E + + + E E+
Sbjct: 350 DRDRTKERDRDRDR---ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERE 406
Query: 656 LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
E ++ E + + + E D K D + D +E +E KL ++E E
Sbjct: 407 REREREREREREREREREREKDKKRDREED-------EEDAYERRKLERKLREKEAAYQE 459
Query: 716 KL 717
+L
Sbjct: 460 RL 461
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/234 (22%), Positives = 97/234 (41%), Gaps = 22/234 (9%)
Query: 495 EEDSPKKESKKKTLKNDCEENGLAKESEDDLN---KESEEEVGPTKESE-EDDSEKESDE 550
EE+ KKE +++ ++ + E +E E + +E E E KE E E + E++ D
Sbjct: 292 EEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDR 351
Query: 551 DCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKV 610
D ++++ D + E+ D E D+E E E E
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE------- 404
Query: 611 LDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADE 670
ERE + + + + E E E+ D + D +EDEE A E+ + +E E
Sbjct: 405 -----REREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQE 459
Query: 671 KLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDER 724
+L K E + K+ + +++ +++ ++ E + E L D D+R
Sbjct: 460 RL------KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
Score = 43.5 bits (101), Expect = 7e-04
Identities = 50/231 (21%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 502 ESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGS 561
++KKK + + + E+ L++E++ K + E + S E + Q D
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 562 EREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE----EGSE 617
R+ ++ E + ++ KE D E E+D + + E +
Sbjct: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKE----DINAIEMEEDKRDLISREISKFRDTH 288
Query: 618 REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD 677
++ +E+ +KE+E EK E E+E E + + E ++ E + +++ E +
Sbjct: 289 KKLEEEKGKKEKERQEIEK----ERRERERERERERERREREREREREREREKEKERERE 344
Query: 678 DKEDEDADGKEVEDADEKLFED-DDSNEKLFDEEED---SSEKLFDDSDER 724
+ D D D + D D D D E+ D +D S EK D ER
Sbjct: 345 RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 76.6 bits (187), Expect = 8e-14
Identities = 78/298 (26%), Positives = 128/298 (42%), Gaps = 29/298 (9%)
Query: 427 DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESE-----EGCPKRGFEGSCS 481
DEK+ EK EG KE E E + E++ + E +R S
Sbjct: 68 DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 127
Query: 482 QKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES-E 540
++E + + E K ++K + E A+E + +E+ EV +
Sbjct: 128 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE--REARREVSAHHRTMR 185
Query: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
ED S+K S ER FE K + EE ++ E L +L+ D +S
Sbjct: 186 EDYSDKVKASHWSRSPPRPPRER-FELGDGRKPVKEE----KMEERDLLSDLQ--DISDS 238
Query: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFDDESDEKEDEEYADEKGLEAA 659
E + +E E GS E +E+ +E+EEEE T E+ ++E +E+E+EE EA+
Sbjct: 239 ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEAS 298
Query: 660 DKKAEEGDADEKLFEESDDKEDE-----------DADGKEVEDADEKLFEDDDSNEKL 706
++ AEE E+ E +++E+E D D E E+A+E++ E + L
Sbjct: 299 EQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSAL 354
Score = 67.8 bits (164), Expect = 4e-11
Identities = 71/331 (21%), Positives = 141/331 (42%), Gaps = 25/331 (7%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEG-----CPKRGFEGSCSQK 483
++ + ED GE ++ + ++ S +++ EK E+ + G +K
Sbjct: 34 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK 93
Query: 484 ESEEGNPVRGSEE-DSPKKESKKKTLKNDCEENGLAKESE-DDLNKESEEEVGPTKESEE 541
E E R EE D ++E +++ + E+ + + L ++ E E ++ +E
Sbjct: 94 EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE 153
Query: 542 DDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSE 601
+KE + E++ E + RE + + + E+ S+K + + + E E
Sbjct: 154 QREQKERERRAEERRKEREARREVSAH--HRTMREDYSDK-VKASHWSRSPPRPPRERFE 210
Query: 602 FEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADK 661
DG + V +E+ ER+ D + + E K ES E ++E+ E ++
Sbjct: 211 L-GDGRKPVKEEKMEERDLLSDLQDISDSE---RKTSSAESSSAESGSGSEEEEEEEEEE 266
Query: 662 KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSS------- 714
+ E ++E EE +++E+E+ G E+A E+ E+ E DEE ++
Sbjct: 267 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 326
Query: 715 EKLFD----DSDERGTLGGFGSVEEGPLSTG 741
E FD +S+E G G+ + L+ G
Sbjct: 327 ESRFDRDSGESEEAEEEVGEGTPQSSALTEG 357
Score = 67.0 bits (162), Expect = 6e-11
Identities = 68/275 (24%), Positives = 116/275 (42%), Gaps = 9/275 (3%)
Query: 340 RQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAP-EANRGLRRSDSVSASERAGPSR 398
R+ + + +G +V+E RE E R R E A E R RR + S R
Sbjct: 75 RRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRL 134
Query: 399 ARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
+ + KM Q+ E+ E++ E+ E S ++ +
Sbjct: 135 EQLERKRERERKMREQQKEQR---EQKERERRAEERRKEREARREVSAHHRTMREDYSDK 191
Query: 459 EEGCPEKESEEGCPKRGFEGSCSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEE 514
+ S P+ FE +K E E + +D E K + ++ E
Sbjct: 192 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 251
Query: 515 NGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDL 574
+G E E++ +E EEE ++ESEE++ E+E +E+ + SE+ SE+ EE E+
Sbjct: 252 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 311
Query: 575 DEEGSEKELHENVLDKELEENDS-ENSEFEDDGSE 608
++E E E H V+ + + DS E+ E E++ E
Sbjct: 312 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 346
Score = 63.5 bits (153), Expect = 7e-10
Identities = 73/292 (25%), Positives = 112/292 (38%), Gaps = 22/292 (7%)
Query: 388 VSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTEDGGEFEEGASE 446
V ER R RH E + ++ MA E E+ + E+ E E E E
Sbjct: 90 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 149
Query: 447 NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG---------NPVRGSEED 497
KE +KE E E+ E + + +E +P R E
Sbjct: 150 QQ-KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 208
Query: 498 SPKKESKKKTLKNDCEENGLAKESEDDLNKE----SEEEVGPTKESEEDDSEKESDEDCS 553
+ +K + EE L + +D + E S E S ++ E+E +E+
Sbjct: 209 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 268
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGS-EKELHENVLDKELEENDSENSEFEDDGSEKVLD 612
E + + SE E EE E++ +E GS +E E ++ EE SE+ E E++ V+
Sbjct: 269 EGSTSEESEEEEEEE--EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 326
Query: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAE 664
E FD DS E EE E+ + S E + D L + K E
Sbjct: 327 ES----RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 374
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 76.6 bits (187), Expect = 8e-14
Identities = 78/298 (26%), Positives = 128/298 (42%), Gaps = 29/298 (9%)
Query: 427 DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESE-----EGCPKRGFEGSCS 481
DEK+ EK EG KE E E + E++ + E +R S
Sbjct: 102 DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 161
Query: 482 QKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES-E 540
++E + + E K ++K + E A+E + +E+ EV +
Sbjct: 162 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE--REARREVSAHHRTMR 219
Query: 541 EDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENS 600
ED S+K S ER FE K + EE ++ E L +L+ D +S
Sbjct: 220 EDYSDKVKASHWSRSPPRPPRER-FELGDGRKPVKEE----KMEERDLLSDLQ--DISDS 272
Query: 601 EFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFDDESDEKEDEEYADEKGLEAA 659
E + +E E GS E +E+ +E+EEEE T E+ ++E +E+E+EE EA+
Sbjct: 273 ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEAS 332
Query: 660 DKKAEEGDADEKLFEESDDKEDE-----------DADGKEVEDADEKLFEDDDSNEKL 706
++ AEE E+ E +++E+E D D E E+A+E++ E + L
Sbjct: 333 EQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSAL 388
Score = 67.8 bits (164), Expect = 4e-11
Identities = 71/331 (21%), Positives = 141/331 (42%), Gaps = 25/331 (7%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEG-----CPKRGFEGSCSQK 483
++ + ED GE ++ + ++ S +++ EK E+ + G +K
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK 127
Query: 484 ESEEGNPVRGSEE-DSPKKESKKKTLKNDCEENGLAKESE-DDLNKESEEEVGPTKESEE 541
E E R EE D ++E +++ + E+ + + L ++ E E ++ +E
Sbjct: 128 EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE 187
Query: 542 DDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSE 601
+KE + E++ E + RE + + + E+ S+K + + + E E
Sbjct: 188 QREQKERERRAEERRKEREARREVSAH--HRTMREDYSDK-VKASHWSRSPPRPPRERFE 244
Query: 602 FEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADK 661
DG + V +E+ ER+ D + + E K ES E ++E+ E ++
Sbjct: 245 L-GDGRKPVKEEKMEERDLLSDLQDISDSE---RKTSSAESSSAESGSGSEEEEEEEEEE 300
Query: 662 KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSS------- 714
+ E ++E EE +++E+E+ G E+A E+ E+ E DEE ++
Sbjct: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
Query: 715 EKLFD----DSDERGTLGGFGSVEEGPLSTG 741
E FD +S+E G G+ + L+ G
Sbjct: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEG 391
Score = 67.0 bits (162), Expect = 6e-11
Identities = 68/275 (24%), Positives = 116/275 (42%), Gaps = 9/275 (3%)
Query: 340 RQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAP-EANRGLRRSDSVSASERAGPSR 398
R+ + + +G +V+E RE E R R E A E R RR + S R
Sbjct: 109 RRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRL 168
Query: 399 ARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
+ + KM Q+ E+ E++ E+ E S ++ +
Sbjct: 169 EQLERKRERERKMREQQKEQR---EQKERERRAEERRKEREARREVSAHHRTMREDYSDK 225
Query: 459 EEGCPEKESEEGCPKRGFEGSCSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEE 514
+ S P+ FE +K E E + +D E K + ++ E
Sbjct: 226 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 285
Query: 515 NGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDL 574
+G E E++ +E EEE ++ESEE++ E+E +E+ + SE+ SE+ EE E+
Sbjct: 286 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 345
Query: 575 DEEGSEKELHENVLDKELEENDS-ENSEFEDDGSE 608
++E E E H V+ + + DS E+ E E++ E
Sbjct: 346 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 380
Score = 63.5 bits (153), Expect = 7e-10
Identities = 73/292 (25%), Positives = 112/292 (38%), Gaps = 22/292 (7%)
Query: 388 VSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTEDGGEFEEGASE 446
V ER R RH E + ++ MA E E+ + E+ E E E E
Sbjct: 124 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 183
Query: 447 NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG---------NPVRGSEED 497
KE +KE E E+ E + + +E +P R E
Sbjct: 184 QQ-KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 242
Query: 498 SPKKESKKKTLKNDCEENGLAKESEDDLNKE----SEEEVGPTKESEEDDSEKESDEDCS 553
+ +K + EE L + +D + E S E S ++ E+E +E+
Sbjct: 243 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 302
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGS-EKELHENVLDKELEENDSENSEFEDDGSEKVLD 612
E + + SE E EE E++ +E GS +E E ++ EE SE+ E E++ V+
Sbjct: 303 EGSTSEESEEEEEEE--EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
Query: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAE 664
E FD DS E EE E+ + S E + D L + K E
Sbjct: 361 ES----RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQE 408
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 76.3 bits (186), Expect = 1e-13
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 198
Query: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 199 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 258
Query: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 259 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 318
Query: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 319 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 377
Query: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 378 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 437
Query: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 438 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 486
Query: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
+ T+ + + G D DD+D
Sbjct: 487 ESRKLTVDAYHNKPIG------------DQDDND 508
Score = 66.6 bits (161), Expect = 8e-11
Identities = 81/367 (22%), Positives = 145/367 (39%), Gaps = 72/367 (19%)
Query: 419 GMAFEEPIDEKKFEKTEDGGEF------------EEGASENNAKESSPEKEAEEGCPEKE 466
G++ P+ + ++ED E+ E S +K SS E+ E+ +
Sbjct: 12 GLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ 71
Query: 467 SEEGCPKR----------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKK 505
SEEG GF S + E + G+ G ++ P ++E
Sbjct: 72 SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGN 131
Query: 506 KTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDE 550
L +D + + + SE+ + + T ES E D+ E ES+E
Sbjct: 132 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 191
Query: 551 DC----SEKQSEDGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSE 601
S+ +S G E ++ G++ D E G+ + + KE EN SE +
Sbjct: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQAN 250
Query: 602 FEDDGSEKVLDEEG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGL 656
+D G ++L+ R +ED + ++ +T E+V D ++ + GL
Sbjct: 251 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL 306
Query: 657 EAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSE 715
+ ++ +GD+ E E +E ++ DG E + E L ++S+E +EE SE
Sbjct: 307 -SQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSE 362
Query: 716 KLFDDSD 722
D+ D
Sbjct: 363 SRGDNPD 369
Score = 66.2 bits (160), Expect = 1e-10
Identities = 81/378 (21%), Positives = 141/378 (37%), Gaps = 31/378 (8%)
Query: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 136 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 195
Query: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 196 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 255
Query: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
E S + K + E ++ N + + DS + + + T + +
Sbjct: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 315
Query: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 316 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 374
Query: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
Query: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
E + +D+SD +D + E K + E D K E K
Sbjct: 435 SHSSSAESQSEESHSEEDDSDS-QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTV 493
Query: 683 DA-DGKEVEDADEKLFED 699
DA K + D D+ +D
Sbjct: 494 DAYHNKPIGDQDDNDCQD 511
Score = 56.2 bits (134), Expect = 1e-07
Identities = 62/228 (27%), Positives = 93/228 (40%), Gaps = 21/228 (9%)
Query: 520 ESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE--- 576
ESED + PT E +S + S E+ +ED S+ E GL D +
Sbjct: 26 ESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIY 85
Query: 577 ---EGSEKELHENVLDKELEENDSENSEFEDDGS---EKVLDEEGSER-EFDEDSDEK-E 628
G + + DK+ +E+DS + F DD S K E G+ R DEDSD+ +
Sbjct: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
Query: 629 EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKE 688
E++ + D D + D + + D K E GD+ +ES+ +E G +
Sbjct: 146 ASEESAPQGQDSAQDTTSESRELDNE--DRVDSKPEGGDST----QESESEEHWVGGGSD 199
Query: 689 VEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEG 736
E + E DD + D E SE+ + R G S E G
Sbjct: 200 GESSHGDGSELDDEGMQSDDPESIRSER----GNSRMNSAGMKSKESG 243
Score = 53.5 bits (127), Expect = 7e-07
Identities = 63/351 (17%), Positives = 124/351 (35%), Gaps = 20/351 (5%)
Query: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
D P+G S + EE W GG + ++ E + E +R
Sbjct: 175 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
Query: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 225 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 282
Query: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 283 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 342
Query: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
Query: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
+ D ES E E + GL+ S+ E + D ++ S +
Sbjct: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 462
Query: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEY 650
E + K EE + + E K + + K D+ D + Y
Sbjct: 463 KEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513
Score = 36.2 bits (82), Expect = 0.12
Identities = 39/157 (24%), Positives = 62/157 (39%), Gaps = 10/157 (6%)
Query: 598 ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
+N+E ED K + + + + + E+ +D SD + EE GL
Sbjct: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE-----GLG 77
Query: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
+ D + A F S K +D D E + D+ F DDDS D +E + +L
Sbjct: 78 SDDHQYIYRLAGG--FSRSTGKGGDDKDDDEDDSGDDT-FGDDDSGPGPKDRQEGGNSRL 134
Query: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
D D T+ S E P S+ +S+ + D
Sbjct: 135 GSDEDSDDTIQ--ASEESAPQGQDSAQDTTSESRELD 169
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 76.3 bits (186), Expect = 1e-13
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 126 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 182
Query: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 183 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 242
Query: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 243 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 302
Query: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 303 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 361
Query: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 362 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 421
Query: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 422 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 470
Query: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
+ T+ + + G D DD+D
Sbjct: 471 ESRKLTVDAYHNKPIG------------DQDDND 492
Score = 66.2 bits (160), Expect = 1e-10
Identities = 81/378 (21%), Positives = 141/378 (37%), Gaps = 31/378 (8%)
Query: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 120 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 179
Query: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 180 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 239
Query: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
E S + K + E ++ N + + DS + + + T + +
Sbjct: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 299
Query: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 300 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 358
Query: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 359 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
Query: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
E + +D+SD +D + E K + E D K E K
Sbjct: 419 SHSSSAESQSEESHSEEDDSDS-QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTV 477
Query: 683 DA-DGKEVEDADEKLFED 699
DA K + D D+ +D
Sbjct: 478 DAYHNKPIGDQDDNDCQD 495
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/355 (21%), Positives = 143/355 (40%), Gaps = 64/355 (18%)
Query: 419 GMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKR---- 474
G++ P+ + ++ED E++ + A+ +P E+ +SEEG
Sbjct: 12 GLSCALPVTRYQNNESEDSEEWKG----HLAQAPTPPLANEDPSDSTQSEEGLGSDDHQY 67
Query: 475 ------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKKKTLKNDCEENGL 517
GF S + E + G+ G ++ P ++E L +D + +
Sbjct: 68 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDT 127
Query: 518 AKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDEDC----SEKQSE 558
+ SE+ + + T ES E D+ E ES+E S+ +S
Sbjct: 128 IQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS 187
Query: 559 DGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
G E ++ G++ D E G+ + + KE EN SE + +D G ++L+
Sbjct: 188 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQANTQDSGGSQLLEH 246
Query: 614 EG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDA 668
R +ED + ++ +T E+V D ++ + GL + ++ +GD+
Sbjct: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL-SQPRRDSKGDS 301
Query: 669 DEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
E E +E ++ DG E + E L ++S+E +EE SE D+ D
Sbjct: 302 QEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSESRGDNPD 353
Score = 53.5 bits (127), Expect = 7e-07
Identities = 63/351 (17%), Positives = 124/351 (35%), Gaps = 20/351 (5%)
Query: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
D P+G S + EE W GG + ++ E + E +R
Sbjct: 159 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 208
Query: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 209 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 266
Query: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 267 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 326
Query: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 327 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 386
Query: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
+ D ES E E + GL+ S+ E + D ++ S +
Sbjct: 387 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 446
Query: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEY 650
E + K EE + + E K + + K D+ D + Y
Sbjct: 447 KEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 497
Score = 33.9 bits (76), Expect = 0.57
Identities = 36/139 (25%), Positives = 58/139 (41%), Gaps = 19/139 (13%)
Query: 622 EDSDEKE---EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK---AEEGDADEKLFEE 675
EDS+E + + T +D SD + EE GL + D + G +
Sbjct: 28 EDSEEWKGHLAQAPTPPLANEDPSDSTQSEE-----GLGSDDHQYIYRLAGGFSRSTGKG 82
Query: 676 SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEE 735
DDK+D++ +D+ + F DDDS D +E + +L D D T+ S E
Sbjct: 83 GDDKDDDE------DDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ--ASEES 134
Query: 736 GPLSTGSSFILSSDDDDDD 754
P S+ +S+ + D
Sbjct: 135 APQGQDSAQDTTSESRELD 153
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 75.9 bits (185), Expect = 1e-13
Identities = 78/296 (26%), Positives = 126/296 (42%), Gaps = 27/296 (9%)
Query: 427 DEKKFEKTEDGGEFEEGASENNAKESSPEKEA---EEGCPEKESEEGCPKRGFEGSCSQK 483
DEK+ EK EG KE E+ EE + E +R S++
Sbjct: 102 DEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 161
Query: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES-EED 542
E + + E K ++K + E A+E + +E+ EV + ED
Sbjct: 162 ERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE--REARREVSAHHRTMRED 219
Query: 543 DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEF 602
S+K S ER FE K + EE ++ E L +L+ D +SE
Sbjct: 220 YSDKVKASHWSRSPPRPPRER-FELGDGRKPVKEE----KMEERDLLSDLQ--DISDSER 272
Query: 603 EDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFDDESDEKEDEEYADEKGLEAADK 661
+ +E E GS E +E+ +E+EEEE T E+ ++E +E+E+EE EA+++
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332
Query: 662 KAEEGDADEKLFEESDDKEDE-----------DADGKEVEDADEKLFEDDDSNEKL 706
AEE E+ E +++E+E D D E E+A+E++ E + L
Sbjct: 333 SAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSAL 386
Score = 67.0 bits (162), Expect = 6e-11
Identities = 67/329 (20%), Positives = 141/329 (42%), Gaps = 23/329 (6%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEE-----GCPKRGFEGSCSQK 483
++ + ED GE ++ + ++ S +++ EK E+ + G ++
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKER 127
Query: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDD 543
E E R ++ + ++ ++K + E + ++ + L ++ E E ++ +E
Sbjct: 128 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 187
Query: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFE 603
+KE + E++ E + RE + + + E+ S+K + + + E E
Sbjct: 188 EQKERERRAEERRKEREARREVSAH--HRTMREDYSDK-VKASHWSRSPPRPPRERFEL- 243
Query: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663
DG + V +E+ ER+ D + + E K ES E ++E+ E +++
Sbjct: 244 GDGRKPVKEEKMEERDLLSDLQDISDSE---RKTSSAESSSAESGSGSEEEEEEEEEEEE 300
Query: 664 EEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSS-------EK 716
E ++E EE +++E+E+ G E+A E+ E+ E DEE ++ E
Sbjct: 301 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360
Query: 717 LFD----DSDERGTLGGFGSVEEGPLSTG 741
FD +S+E G G+ + L+ G
Sbjct: 361 RFDRDSGESEEAEEEVGEGTPQSSALTEG 389
Score = 65.5 bits (158), Expect = 2e-10
Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 38/254 (14%)
Query: 392 ERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTEDGGEFEEGASENNAK 450
ER R RH E + ++ MA E E+ + E+ E E E E K
Sbjct: 126 EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQ-K 184
Query: 451 ESSPEKEAEEGCPEKESEEGC-------------------------------PKRGFEGS 479
E +KE E E+ E P+ FE
Sbjct: 185 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 244
Query: 480 CSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
+K E E + +D E K + ++ E+G E E++ +E EEE
Sbjct: 245 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 304
Query: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
++ESEE++ E+E +E+ + SE+ SE+ EE E+ ++E E E H V+ + +
Sbjct: 305 SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDR 364
Query: 596 DS-ENSEFEDDGSE 608
DS E+ E E++ E
Sbjct: 365 DSGESEEAEEEVGE 378
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 75.9 bits (185), Expect = 1e-13
Identities = 86/408 (21%), Positives = 179/408 (43%), Gaps = 44/408 (10%)
Query: 351 TDYQVEETSREREERLRGWEAF-----LNAPEANRGLRRSDSVSASERAGPSRARHFSEH 405
TD +++E + + +E+L+ E+ LN E R L R+ + ++ E
Sbjct: 276 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 335
Query: 406 PSTS-KMNAQ--ETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC 462
S S K+ AQ E + +EK + + E E+EE E K E++ E
Sbjct: 336 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 395
Query: 463 PEKESEEGCPKRGFEGSCSQKES--EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
+ +E E Q+E E+ +R EE +KE K + L+ E +E
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 455
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSE 580
E+ ++ EE++ ++ +E +++ E+ +Q E E+E + E+ + E+
Sbjct: 456 QEE--KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 581 KELHENVLDKELEENDSENSEFED---------DGSEKVLDEEGS-----EREFDEDSDE 626
+E + +E+ + + E E+ + EK+ +E E+ D++
Sbjct: 514 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 627 KEEEEDTY---EKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDED 683
+E+EE + EK+ + E +E EE E+ +++ + G+ +EK+ E+ + ++++
Sbjct: 574 REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 684 A-----------DGKEVEDADEKLFEDD----DSNEKLFDEEEDSSEK 716
K++ + +EK+ E + + EK++++EE E+
Sbjct: 634 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681
Score = 68.2 bits (165), Expect = 3e-11
Identities = 84/369 (22%), Positives = 160/369 (43%), Gaps = 28/369 (7%)
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA 413
Q EE +EE+++ WE + E R E+ R + KM
Sbjct: 358 QQEEKMWRQEEKIQEWEEKIQEQEEKI---REQEEKIREQEEKMRRQEEMMWEKEEKMRR 414
Query: 414 QETATGMAFEEPI--DEKKFEKTEDGGEFEEGASENNA-KESSPEKEAEEGCPEKESEEG 470
QE E+ +E +EK E E EE E +E +++ EE E+E +
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 471 CPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESE 530
+ + +E EE +R EE ++E K + EE K E + E
Sbjct: 475 QEAKMWRQEEKIREQEE--KIREQEEKMWRQEEKIHEQEKIREEE---KRQEQEEMWRQE 529
Query: 531 EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDK 590
E++ +E EE +KE + EK + + +E EK D+E +E E V +
Sbjct: 530 EKI---REQEEIWRQKEKIHEQEEKIRKQEEKMWRQE---EKMHDQEEKIREQEEKVWRQ 583
Query: 591 ELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEY 650
E + + E E + EK+ ++E +E +E E+EE+ E ++ E+E++
Sbjct: 584 EEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQE----EKMQEQEEKMR 637
Query: 651 ADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
E+ + +KK E +EK+ E+ + ++++ +++ + +EK+ E ++ ++ ++
Sbjct: 638 RQEEKIREQEKKIRE--QEEKIREQEEMMQEQE---EKMWEQEEKMCEQEEKMQEQEEKM 692
Query: 711 EDSSEKLFD 719
EK+++
Sbjct: 693 RRQEEKMWE 701
Score = 50.8 bits (120), Expect = 5e-06
Identities = 81/323 (25%), Positives = 134/323 (41%), Gaps = 34/323 (10%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
EE E+EE++R E + E + + + E+ + E + QE
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKE-EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 416 TATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPK-- 473
M +E EK E+ E E EE K EK EE +++ E +
Sbjct: 475 QEAKMWRQE---EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531
Query: 474 -RGFEGSCSQKES--EEGNPVRGSEEDSPKKESKKKTLKNDCEENG--------LAKESE 522
R E QKE E+ +R EE ++E K + E +E E
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE 591
Query: 523 DDLNKESE---EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGS 579
+ + ++ E E+ T+E EE E+E ++ C +Q E E+E + E+ + E+
Sbjct: 592 EKIREQEEKIREQEEMTQEQEEKMGEQE-EKMC--EQEEKMQEQEEKMRRQEEKIREQ-- 646
Query: 580 EKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEE-EDTYEKVF 638
EK++ +E EE E E + EK+ ++E E +E E+EE+ EK++
Sbjct: 647 EKKI------REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 700
Query: 639 DDESDEKEDEEYADE--KGLEAA 659
+ E ++ EE E + LEAA
Sbjct: 701 EQEVRLRQQEEKMQEHQEHLEAA 723
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 74.7 bits (182), Expect = 3e-13
Identities = 71/208 (34%), Positives = 110/208 (52%), Gaps = 33/208 (15%)
Query: 502 ESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESD---EDCSEKQSE 558
E K++ +++ E+ G KE+ K EE+ KE EED +E++ + ED EK E
Sbjct: 99 EVKEENIEDATEKGGEKKEAVAAEVKNEEED---QKEDEEDQNEEKGEAGKEDKDEKGEE 155
Query: 559 DGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSER 618
DG E ++NG EK E+ EKE D + E+ N E DG EK DE+ E
Sbjct: 156 DGKE---DKNGNEKG--EDAKEKE------DGKKGEDGKGNGE---DGKEKGEDEK--EE 199
Query: 619 EFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD 678
E +++ + +E ED EK D+ + K+ + DEK E D K +EG +E+ +E +D
Sbjct: 200 EDRKETGDGKENEDGKEK--GDKKEGKDVKVKEDEK--EREDGKEDEGGNEEEAGKEKED 255
Query: 679 -KEDEDADGKEVEDADEKLFEDDDSNEK 705
KE+E +GKE ++++ EDD E+
Sbjct: 256 LKEEE--EGKE----EDEIKEDDGKKEE 277
Score = 73.2 bits (178), Expect = 9e-13
Identities = 76/267 (28%), Positives = 119/267 (44%), Gaps = 35/267 (13%)
Query: 389 SASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENN 448
++S R +++ E+ TS ET EE +E K + E ASE
Sbjct: 39 TSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENA--KNGEAKITEAPASEKE 96
Query: 449 ---AKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVR----GSEEDSPKK 501
KE + E E+G +KE+ K E QKE EE G E+ K
Sbjct: 97 IVEVKEENIEDATEKGGEKKEAVAAEVKNEEE---DQKEDEEDQNEEKGEAGKEDKDEKG 153
Query: 502 ESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGS 561
E K KN E+ AKE ED K+ E+ G ++ +E +++ +ED K++ DG
Sbjct: 154 EEDGKEDKNGNEKGEDAKEKED--GKKGEDGKGNGEDGKEKGEDEKEEED--RKETGDGK 209
Query: 562 EREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFD 621
E E +G EK +EG + ++ E+ ++E DG E DE G+E E
Sbjct: 210 ENE---DGKEKGDKKEGKDVKVKEDEKERE-------------DGKE---DEGGNEEEAG 250
Query: 622 EDSDEKEEEEDTYEKVFDDESDEKEDE 648
++ ++ +EEE+ E+ E D K++E
Sbjct: 251 KEKEDLKEEEEGKEEDEIKEDDGKKEE 277
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/206 (29%), Positives = 106/206 (51%), Gaps = 18/206 (8%)
Query: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEEN---GLEKDLDEEGSEKELHENVLDKEL 592
TK +++ S + +E + E E ++ EN G K + SEKE+ E V ++ +
Sbjct: 47 TKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVE-VKEENI 105
Query: 593 EENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
E+ + E ++ + +V +EE ++E +ED +E++ E +K E D KED+ +
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKN-GN 164
Query: 653 EKGLEAAD----KKAEEGDADEKLFEE--SDDKEDED----ADGKEVEDADEKLFEDDDS 702
EKG +A + KK E+G + + +E D+KE+ED DGKE ED EK + +
Sbjct: 165 EKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGK 224
Query: 703 NEKLFDEE---EDSSEKLFDDSDERG 725
+ K+ ++E ED E + +E G
Sbjct: 225 DVKVKEDEKEREDGKEDEGGNEEEAG 250
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/259 (27%), Positives = 117/259 (45%), Gaps = 29/259 (11%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKES--- 485
+K + D E S E+ E EE E+ + + E S+KE
Sbjct: 43 RKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDY--NENAKNGEAKITEAPASEKEIVEV 100
Query: 486 EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSE 545
+E N +E+ KKE+ +KN+ E+ KE E+D N+E E E+ D +
Sbjct: 101 KEENIEDATEKGGEKKEAVAAEVKNEEEDQ---KEDEEDQNEEKGEA-----GKEDKDEK 152
Query: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFE-- 603
E D + +E G + + +E+G +K D +G+ ++ E D++ EE+ E + +
Sbjct: 153 GEEDGKEDKNGNEKGEDAKEKEDG-KKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKEN 211
Query: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663
+DG EK +EG + + ED E+E D + DE +EE E G E D K
Sbjct: 212 EDGKEKGDKKEGKDVKVKEDEKERE----------DGKEDEGGNEE---EAGKEKEDLKE 258
Query: 664 EEGDADEKLFEESDDKEDE 682
EE +E +E D K++E
Sbjct: 259 EEEGKEEDEIKEDDGKKEE 277
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 34/278 (12%)
Query: 472 PKRGFEGSCSQKESEEGNPVRGSE-------EDSPKKES---KKKTLKNDCEEN------ 515
PKR G ++ + R S E PK+ S K KT + EEN
Sbjct: 2 PKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQ 61
Query: 516 --------GLAKESEDDLNKESEEEV--GPTKESEEDDSEKESDEDCSEKQSEDGSEREF 565
+ +E ++ K E ++ P E E + ++E+ ED +EK G E++
Sbjct: 62 AVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEK----GGEKKE 117
Query: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSD 625
K+ +E+ E E +N E + D + ED +K +E+G + + ED
Sbjct: 118 AVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGK 177
Query: 626 EKEEEEDTYEKVFDDESDEKEDEEYADE-KGLEAADKKAEEGDADEKLFEESDDKEDEDA 684
+ E+ + E + DEKE+E+ + G E D K E+GD E + + E E
Sbjct: 178 KGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGK-EKGDKKEGKDVKVKEDEKERE 236
Query: 685 DGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
DGKE E +E+ E E L +EEE E + D
Sbjct: 237 DGKEDEGGNEE--EAGKEKEDLKEEEEGKEEDEIKEDD 272
Score = 62.8 bits (151), Expect = 1e-09
Identities = 56/195 (28%), Positives = 95/195 (48%), Gaps = 21/195 (10%)
Query: 555 KQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEE 614
K++ + + + + +E+++D S + + E + +EE+ +EN++ +G K+ +
Sbjct: 37 KRTSSSRKMKTKSDMMEENIDT--SAQAVAETKQEAVVEEDYNENAK---NGEAKITEAP 91
Query: 615 GSEREFDE-------DSDEK--EEEEDTYEKVFDDESDEKEDEE-YADEK---GLEAADK 661
SE+E E D+ EK E++E +V ++E D+KEDEE +EK G E D+
Sbjct: 92 ASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDE 151
Query: 662 KAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDS 721
K EE ++K E + E DGK+ ED +D EK DE+E+ K D
Sbjct: 152 KGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKG---NGEDGKEKGEDEKEEEDRKETGDG 208
Query: 722 DERGTLGGFGSVEEG 736
E G +EG
Sbjct: 209 KENEDGKEKGDKKEG 223
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 10/137 (7%)
Query: 428 EKKFEKTEDGGEFEEGASEN--NAKESSPEKEAEEGCPEKES--EEGCPKRGFEGSCSQK 483
E K EK E+ G+ ++ +E +AKE K+ E+G E E+G ++ E +K
Sbjct: 147 EDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEE---DRK 203
Query: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEE-- 541
E+ +G +E KKE K +K D +E KE E +E+ +E KE EE
Sbjct: 204 ETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGK 263
Query: 542 -DDSEKESDEDCSEKQS 557
+D KE D E QS
Sbjct: 264 EEDEIKEDDGKKEEPQS 280
Score = 43.5 bits (101), Expect = 7e-04
Identities = 46/184 (25%), Positives = 72/184 (39%), Gaps = 12/184 (6%)
Query: 355 VEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQ 414
+E+ + + E+ A + E ++ D AG E N
Sbjct: 105 IEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGN 164
Query: 415 ETATGMAFEEPIDEKKFEKTEDGGEF-----EEGASENNAKESSPEKEAEEGCPEKESEE 469
E G +E D KK E + GE E+ E + KE+ KE E+G + + +E
Sbjct: 165 EK--GEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKE 222
Query: 470 GCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKES 529
G + E +KE E+G G E+ KE K+ LK + E + EDD KE
Sbjct: 223 GKDVKVKE---DEKEREDGKEDEGGNEEEAGKE--KEDLKEEEEGKEEDEIKEDDGKKEE 277
Query: 530 EEEV 533
+ +
Sbjct: 278 PQSI 281
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 74.7 bits (182), Expect = 3e-13
Identities = 83/310 (26%), Positives = 137/310 (44%), Gaps = 23/310 (7%)
Query: 417 ATGMAFEEPIDEKKFEKTED-GGEFEEGASE--NNAKESSPEKEAEEGCPEKESEEGCPK 473
A G A E + ED +FEE +E + K+ P+ E E E++ +E P
Sbjct: 816 AIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIED--EEKLKETEP- 872
Query: 474 RGFEGSCSQKESE-EGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEE 532
E QKE E P +E E + + + E + K+ DD+ K +E
Sbjct: 873 --VEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEG 930
Query: 533 VGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKEL 592
G + SE D E++++ + +E+ EDG E ++E S K + + ++
Sbjct: 931 AGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKR 990
Query: 593 EENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
E S + E+D E + E+G + +E++DE+++ ED E+ ++ E E ED A
Sbjct: 991 ESVASGDDRAEEDMDEAI--EKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMA- 1047
Query: 653 EKGLEAADKKAEEGDADEKL-FEESDDKE-DEDADGKEVEDA--DEKLFEDDDSNEKLFD 708
DK AE G A+E+ F + K+ + G+E + DE L +S D
Sbjct: 1048 -----VVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASD 1102
Query: 709 EE--EDSSEK 716
EE ED E+
Sbjct: 1103 EENREDQPEE 1112
Score = 50.4 bits (119), Expect = 6e-06
Identities = 88/434 (20%), Positives = 164/434 (37%), Gaps = 72/434 (16%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
E S+E ++ A A + + +V + P + E P ++
Sbjct: 606 EVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED 665
Query: 416 TATGMAFEEPIDEK-KFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKES-----EE 469
E+P E+ K E ++ + E+ + K+ +P KE ++ ++E EE
Sbjct: 666 KTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Query: 470 GCPKRGFEG--SCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDD--L 525
PK+ + ++K S + + PK K++++K D G KE +
Sbjct: 726 KEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVI 785
Query: 526 NKESEEE------------------------VGPTKESEEDDSEKESDEDCSEKQSEDGS 561
KE + +GP KE E + S S ED ++ E +
Sbjct: 786 KKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKA 845
Query: 562 EREFEENGLEKDLDEEGSEKELHEN------VLDKELE------------------ENDS 597
E ++ L+ E++L E V+ KE E E +
Sbjct: 846 EEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGEC 905
Query: 598 ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
E + E + EK ++ + E + E+ E YE+ + E E+ +E+ + +
Sbjct: 906 EQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVS 965
Query: 658 AA------DKKAEEGDADEKLFEE------SDDKEDEDADGKEVEDADEKLFEDDDSNEK 705
A+ D+++ + +AD + E+ DD+ +ED D + E+ E+ D +K
Sbjct: 966 ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025
Query: 706 LFD--EEEDSSEKL 717
D EEE EK+
Sbjct: 1026 AEDAREEEYEPEKM 1039
Score = 41.2 bits (95), Expect = 0.004
Identities = 47/196 (23%), Positives = 86/196 (43%), Gaps = 24/196 (12%)
Query: 482 QKESEEGNPVR---GSEEDSPKKESKKKTL-KNDCEENGLAKESEDDLNKESEEEVGPTK 537
+KES+E P E PK ESK+K + K D K S + S+EE P K
Sbjct: 558 RKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVK 617
Query: 538 ESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKEL--EEN 595
+ +EKQ+ D + +E ++K+ + +K+ + KE+ +E+
Sbjct: 618 ------------AEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED 665
Query: 596 DSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEE------EEDTYEKVFDDESDEKEDEE 649
+ + E E+V E E + +E + K+E ++ ++V +E E + EE
Sbjct: 666 KTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Query: 650 YADEKGLEAADKKAEE 665
+K ++ K A++
Sbjct: 726 KEPKKEIKKLPKDAKK 741
Score = 39.3 bits (90), Expect = 0.014
Identities = 84/368 (22%), Positives = 144/368 (39%), Gaps = 56/368 (15%)
Query: 404 EHPSTSKMNAQETATGMAFEEPIDEKKFE--KTEDGGEFEEGASENNAKESSPEKEAEEG 461
E P +K+N E + +E + KK + KTE E E +KE +AE
Sbjct: 564 ETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTE--KEVPSKEEPSPVKAEVA 621
Query: 462 CPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKES 521
EK++ + PK E + +KE++ + E++ PKKE KK E
Sbjct: 622 --EKQATDVKPKAAKEKTV-KKETKVKPEDKKEEKEKPKKEVAKK-------------ED 665
Query: 522 EDDLNKESEEEVGPTKESEEDDSEKE-SDEDCSEKQSEDGSEREFEENGLE------KDL 574
+ + KE + P KE + + +KE E+ E + E E +E E K++
Sbjct: 666 KTPIKKEEK----PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEV 721
Query: 575 DEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTY 634
+E E + L K+ +++ + SE + + K + E + + +E
Sbjct: 722 KKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGK 781
Query: 635 EKVFDDESDEKEDEEYADEKGLE----------AADKKAEEGDADEKLFEESDD--KEDE 682
KV E E A G AA A+E +A+ L +D K+ E
Sbjct: 782 IKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE 841
Query: 683 DADGKEVE------------DADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDER-GTLGG 729
+ +EV+ + +EKL E + + +E + ++ + DE T G
Sbjct: 842 ELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG 901
Query: 730 FGSVEEGP 737
G E+ P
Sbjct: 902 EGECEQTP 909
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 73.6 bits (179), Expect = 7e-13
Identities = 82/328 (25%), Positives = 142/328 (43%), Gaps = 13/328 (3%)
Query: 414 QETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC-- 471
+E A M E+ ++ E+ + E E A ++ K ++PE + EEG EKE EEG
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG--EKEEEEGQEE 535
Query: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEE 531
+ EG+ S + E G+ GS E K+E +++ + + E G E++++ E +
Sbjct: 536 EEEEDEGAKSDQAEEGGSEKEGSSE---KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592
Query: 532 EVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKE 591
E TKE D++ E E + E + + + ++E+G V +E
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV--EE 650
Query: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
++ S E+ G V E+ EE + +V E E+E++E
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 652 DEKGLEAADKKAEE-GDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
+ E +KK E+ D EK ES KE+ A+ + + + E + E ++
Sbjct: 711 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ 770
Query: 711 EDSSEKLFDD--SDERGT-LGGFGSVEE 735
E EK + S+E G+ G GS +E
Sbjct: 771 EKEKEKAGGEGGSEEEGSDKGAKGSRKE 798
Score = 69.7 bits (169), Expect = 9e-12
Identities = 91/355 (25%), Positives = 140/355 (39%), Gaps = 65/355 (18%)
Query: 423 EEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQ 482
EE I+E K E ++ E EE + + + KE ++ E++ EE
Sbjct: 454 EEIIEETKVE--DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE------------- 498
Query: 483 KESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEED 542
E+EE EE + KK K T EE G +E E +E E+E + ++EE
Sbjct: 499 PEAEE-------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 551
Query: 543 DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSE---- 598
SEKE + E + E+G E E E G E + EE +E E V KE D++
Sbjct: 552 GSEKEGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 599 --------NSEFEDDGSEKV----LDEEGSE-------REFDEDSDEKEEEEDTYEKVFD 639
S E+ G V ++E+G E + K E+ +
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 670
Query: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKE---DEDADGKE--VEDADE 694
E++ + + +E A KAE G ++K EE + KE +E + KE +D E
Sbjct: 671 KSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE 730
Query: 695 KLFEDDDSNEKLFDE------------EEDSSE--KLFDDSDERGTLGGFGSVEE 735
K + E+ E E+++ E K E+ GG G EE
Sbjct: 731 KKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE 785
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 7/198 (3%)
Query: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
S+ PK E+ K +++ E + + +D E EE + E ++E E
Sbjct: 434 SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 493
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
EK+ E +E EE K + + E+ E +KE EE E E ++ +E
Sbjct: 494 EKEEEPEAE---EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 614 EGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLF 673
GSE+E + +E E+EE E + E E ++E+ +EK E A K EE AD K+
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK--EELVADAKV- 607
Query: 674 EESDDKEDEDADGKEVED 691
E +K VE+
Sbjct: 608 -EKPEKAKSPVPKSPVEE 624
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/361 (21%), Positives = 140/361 (38%), Gaps = 20/361 (5%)
Query: 345 QAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSE 404
+A T+ E++E E A E ++S + + E
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 405 HPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPE 464
+ E A EE EK+ ++ GE EEG +E A+ E + E+ E
Sbjct: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 465 KESEEGCPKRGFEGSCSQKESEEGNPVRGSEED---------SPKKESKKKTL-KNDCEE 514
K E + + +K + +PV S + SP +E K + K+ EE
Sbjct: 591 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 650
Query: 515 NGLAKESEDDLNKESEEEV--GPTKESEEDDSEKESDEDCSEK-QSEDGSEREFEENGLE 571
G + + + ++ + V P +E + K E+ K + G ++E EE ++
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 572 KDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE 631
+ EE EK+ + K++ E S +++ +V+ S + E ++E +
Sbjct: 711 EAPKEEKVEKKEEK---PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 767
Query: 632 DTYEKVFDDESDEKEDEEYADEKGLEAADKK--AEEGDADEKLFEESDDKEDEDADGKEV 689
EK + E EE +KG + + K+ A G+ + K EE + + E G+E
Sbjct: 768 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK--EEVEQETKEKGSGREE 825
Query: 690 E 690
E
Sbjct: 826 E 826
Score = 60.1 bits (144), Expect = 7e-09
Identities = 64/264 (24%), Positives = 111/264 (42%), Gaps = 40/264 (15%)
Query: 410 KMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEE 469
K +E + P++EK E+G S +S E++A+ P+ EE
Sbjct: 632 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP--VSKSPVEEKAKSPVPKSPVEE 689
Query: 470 GCPKRGFEGSCSQKESEEGNPVRG-------SEEDSPKKESKKKTLKNDCEENGLA---- 518
K G QKE EE +E+ PK +KK ++ +E +A
Sbjct: 690 AKSKAEV-GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 748
Query: 519 --KESEDDLNKESEEEVGPT---KESEEDDSEKESDEDCSEKQSEDGSEREFEENG---- 569
K + L KE++EE P KE E+ E S+E+ S+K ++ + + NG
Sbjct: 749 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG 808
Query: 570 ---LEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSD- 625
+E++ E+GS +E + V+ L+ + ++ + D EKV+ + E+ E D
Sbjct: 809 KEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 868
Query: 626 -------------EKEEEEDTYEK 636
+ EE E+T+E+
Sbjct: 869 ATKYITKSVTVTQKVEEHEETFEE 892
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/150 (25%), Positives = 74/150 (49%), Gaps = 15/150 (10%)
Query: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
E + ++ +++ +EE E+ + E + + + EE + +E + EE+E
Sbjct: 442 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE----- 496
Query: 637 VFDDESDEKEDEEYADEKG---LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDAD 693
E E E+EE A +K A + K EEG+ +E EE ++E+E+ +G + + A+
Sbjct: 497 ----EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEGAKSDQAE 549
Query: 694 EKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
E E + S+EK E+E+ + + +E
Sbjct: 550 EGGSEKEGSSEKEEGEQEEGETEAEAEGEE 579
Score = 38.5 bits (88), Expect = 0.023
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 630 EEDTYEKVFDDESDEKED------EEYA---DEKGLEAADKKAEEGDADEKLFEESDDKE 680
EE E +DE E E+ EE A E+ EAA++K EE +A+E+ E + K
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE--EVAAKKS 511
Query: 681 DEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGT-LGGFGSVEEGPLS 739
A EV++ + + E++ E +EEED K D ++E G+ G EEG
Sbjct: 512 PVKATAPEVKEEEGEKEEEEGQEE---EEEEDEGAK-SDQAEEGGSEKEGSSEKEEGEQE 567
Query: 740 TGSS 743
G +
Sbjct: 568 EGET 571
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 73.6 bits (179), Expect = 7e-13
Identities = 82/328 (25%), Positives = 142/328 (43%), Gaps = 13/328 (3%)
Query: 414 QETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC-- 471
+E A M E+ ++ E+ + E E A ++ K ++PE + EEG EKE EEG
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG--EKEEEEGQEE 159
Query: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEE 531
+ EG+ S + E G+ GS E K+E +++ + + E G E++++ E +
Sbjct: 160 EEEEDEGAKSDQAEEGGSEKEGSSE---KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 216
Query: 532 EVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKE 591
E TKE D++ E E + E + + + ++E+G V +E
Sbjct: 217 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV--EE 274
Query: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
++ S E+ G V E+ EE + +V E E+E++E
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334
Query: 652 DEKGLEAADKKAEE-GDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEE 710
+ E +KK E+ D EK ES KE+ A+ + + + E + E ++
Sbjct: 335 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ 394
Query: 711 EDSSEKLFDD--SDERGT-LGGFGSVEE 735
E EK + S+E G+ G GS +E
Sbjct: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRKE 422
Score = 69.7 bits (169), Expect = 9e-12
Identities = 91/355 (25%), Positives = 140/355 (39%), Gaps = 65/355 (18%)
Query: 423 EEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQ 482
EE I+E K E ++ E EE + + + KE ++ E++ EE
Sbjct: 78 EEIIEETKVE--DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE------------- 122
Query: 483 KESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEED 542
E+EE EE + KK K T EE G +E E +E E+E + ++EE
Sbjct: 123 PEAEE-------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
Query: 543 DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSE---- 598
SEKE + E + E+G E E E G E + EE +E E V KE D++
Sbjct: 176 GSEKEGSSEKEEGEQEEG-ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 599 --------NSEFEDDGSEKV----LDEEGSE-------REFDEDSDEKEEEEDTYEKVFD 639
S E+ G V ++E+G E + K E+ +
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 294
Query: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKE---DEDADGKE--VEDADE 694
E++ + + +E A KAE G ++K EE + KE +E + KE +D E
Sbjct: 295 KSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE 354
Query: 695 KLFEDDDSNEKLFDE------------EEDSSE--KLFDDSDERGTLGGFGSVEE 735
K + E+ E E+++ E K E+ GG G EE
Sbjct: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE 409
Score = 67.8 bits (164), Expect = 4e-11
Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 7/198 (3%)
Query: 494 SEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCS 553
S+ PK E+ K +++ E + + +D E EE + E ++E E
Sbjct: 58 SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 117
Query: 554 EKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
EK+ E +E EE K + + E+ E +KE EE E E ++ +E
Sbjct: 118 EKEEEPEAE---EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 614 EGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLF 673
GSE+E + +E E+EE E + E E ++E+ +EK E A K EE AD K+
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK--EELVADAKV- 231
Query: 674 EESDDKEDEDADGKEVED 691
E +K VE+
Sbjct: 232 -EKPEKAKSPVPKSPVEE 248
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/361 (21%), Positives = 140/361 (38%), Gaps = 20/361 (5%)
Query: 345 QAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSE 404
+A T+ E++E E A E ++S + + E
Sbjct: 95 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
Query: 405 HPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPE 464
+ E A EE EK+ ++ GE EEG +E A+ E + E+ E
Sbjct: 155 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
Query: 465 KESEEGCPKRGFEGSCSQKESEEGNPVRGSEED---------SPKKESKKKTL-KNDCEE 514
K E + + +K + +PV S + SP +E K + K+ EE
Sbjct: 215 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 274
Query: 515 NGLAKESEDDLNKESEEEV--GPTKESEEDDSEKESDEDCSEK-QSEDGSEREFEENGLE 571
G + + + ++ + V P +E + K E+ K + G ++E EE ++
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334
Query: 572 KDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE 631
+ EE EK+ + K++ E S +++ +V+ S + E ++E +
Sbjct: 335 EAPKEEKVEKKEEK---PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
Query: 632 DTYEKVFDDESDEKEDEEYADEKGLEAADKK--AEEGDADEKLFEESDDKEDEDADGKEV 689
EK + E EE +KG + + K+ A G+ + K EE + + E G+E
Sbjct: 392 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK--EEVEQETKEKGSGREE 449
Query: 690 E 690
E
Sbjct: 450 E 450
Score = 60.1 bits (144), Expect = 7e-09
Identities = 64/264 (24%), Positives = 111/264 (42%), Gaps = 40/264 (15%)
Query: 410 KMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEE 469
K +E + P++EK E+G S +S E++A+ P+ EE
Sbjct: 256 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP--VSKSPVEEKAKSPVPKSPVEE 313
Query: 470 GCPKRGFEGSCSQKESEEGNPVRG-------SEEDSPKKESKKKTLKNDCEENGLA---- 518
K G QKE EE +E+ PK +KK ++ +E +A
Sbjct: 314 AKSKAEV-GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 372
Query: 519 --KESEDDLNKESEEEVGPT---KESEEDDSEKESDEDCSEKQSEDGSEREFEENG---- 569
K + L KE++EE P KE E+ E S+E+ S+K ++ + + NG
Sbjct: 373 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG 432
Query: 570 ---LEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSD- 625
+E++ E+GS +E + V+ L+ + ++ + D EKV+ + E+ E D
Sbjct: 433 KEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 492
Query: 626 -------------EKEEEEDTYEK 636
+ EE E+T+E+
Sbjct: 493 ATKYITKSVTVTQKVEEHEETFEE 516
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/150 (25%), Positives = 74/150 (49%), Gaps = 15/150 (10%)
Query: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
E + ++ +++ +EE E+ + E + + + EE + +E + EE+E
Sbjct: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE----- 120
Query: 637 VFDDESDEKEDEEYADEKG---LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDAD 693
E E E+EE A +K A + K EEG+ +E EE ++E+E+ +G + + A+
Sbjct: 121 ----EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEGAKSDQAE 173
Query: 694 EKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
E E + S+EK E+E+ + + +E
Sbjct: 174 EGGSEKEGSSEKEEGEQEEGETEAEAEGEE 203
Score = 38.5 bits (88), Expect = 0.023
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 16/124 (12%)
Query: 630 EEDTYEKVFDDESDEKED------EEYA---DEKGLEAADKKAEEGDADEKLFEESDDKE 680
EE E +DE E E+ EE A E+ EAA++K EE +A+E+ E + K
Sbjct: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE--EVAAKKS 135
Query: 681 DEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGT-LGGFGSVEEGPLS 739
A EV++ + + E++ E +EEED K D ++E G+ G EEG
Sbjct: 136 PVKATAPEVKEEEGEKEEEEGQEE---EEEEDEGAK-SDQAEEGGSEKEGSSEKEEGEQE 191
Query: 740 TGSS 743
G +
Sbjct: 192 EGET 195
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 73.2 bits (178), Expect = 9e-13
Identities = 117/567 (20%), Positives = 243/567 (42%), Gaps = 58/567 (10%)
Query: 189 LKRESVELALKL-LDEDE-------IRGYKLHVEVAKFQLKG------EYDASKKKKKCK 234
LK+++ EL KL L E E ++ K +E AKF L + + +++++ +
Sbjct: 223 LKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 282
Query: 235 DYKKKLSMQQKQLDWRPERRA----GPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIRED 290
+ +KK+ Q++++ WR E R G R + E++ + + E L E ++
Sbjct: 283 EQEKKIRKQEEKM-WRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-----LREQEKE 336
Query: 291 LRVECSKFGQIRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGT 350
LR E + + + + R+ EE + + + W +Q+ Q
Sbjct: 337 LR-EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW--RQEERLWEQEKQMREQEQKMR 393
Query: 351 TD----YQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHP 406
++ +E RE+EER+R E E R ++ R + +
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 407 STSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEK--EAEEGCPE 464
K +E T EE + ++ EE E KE ++ E +E E
Sbjct: 454 EREKKMREEEETMREQEEKMQKQ-----------EENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 465 KESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDD 524
+E + ++ +E ++ EE + G E+ ++E ++ E+ ++ E
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEE---MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 525 LNKESEEEVGPTKESEE---DDSEKESDED-CSEKQSEDGSEREFEENGLEKDLDEEGSE 580
+ + E T+E E+ D EK +E+ E++ + E E EK ++E
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 581 KELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDD 640
+E E + ++E + + E +E + EK+ ++E E ++KE+ + +EK+ +
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQE--EKMWEQEEKMWEQQRLPEQKEKLWE-HEKMQEQ 676
Query: 641 ESDEKEDEEYADEKGLEAADKKAEEGDAD-EKLFEESDDKEDEDADGKEVEDADEKLFED 699
E ++++E+ +++ +E ++ E+ D EK+ EE +E E +E E E+ +
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 700 DDSNEKLFDEEE---DSSEKLFDDSDE 723
+ EK+ ++EE + EK+++ ++
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEK 763
Score = 73.2 bits (178), Expect = 9e-13
Identities = 80/374 (21%), Positives = 165/374 (44%), Gaps = 27/374 (7%)
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA 413
Q EE RERE+++R E + E + + E+ + + +
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506
Query: 414 QETATGMAFEEPIDEKKFEKTED-----GGEFEEGASENNAKESSPEKEAEEGCPEKESE 468
QE EE I E++ EK D G E + E ++ E EE ++E +
Sbjct: 507 QEQ------EEKIWEQE-EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 469 EGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKE 528
+ E ++E + + E+ +E +KK EE + +E E+ + +E
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR----EEEEMMREQEEKM-QE 614
Query: 529 SEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVL 588
EE++ +E + EK +++ + E+ + E+ ++ L E+ + HE +
Sbjct: 615 QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 674
Query: 589 DKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDE 648
++E + + E +E + EK E+ + E E+E + +K+ ++E +E E
Sbjct: 675 EQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 649 EYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDD--DSNEKL 706
E E+ + +++ E + +EK++E+ E++ + + + + EKL+E + EK+
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQ----EEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Query: 707 FDEEE---DSSEKL 717
+++EE D EK+
Sbjct: 790 WEQEEKMRDQEEKM 803
Score = 69.3 bits (168), Expect = 1e-11
Identities = 110/551 (19%), Positives = 230/551 (41%), Gaps = 57/551 (10%)
Query: 203 EDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKLSMQQKQLDWRPERRAGPS-RMR 261
E E+R + + K + E ++++K + ++K+ Q++++ WR E R +
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM-WRQEERLWEQEKQM 385
Query: 262 HERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFRD 321
E+ +++ M +D+ L E E +R + + Q+ K+ + + RD
Sbjct: 386 REQEQKMRDQEERMWEQDERL--REKEERMREQEKMWEQVEKMREEKKMQEQEKKT--RD 441
Query: 322 PEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRG-----WEAFLNAP 376
EE + + R R+ EET RE+EE+++ WE
Sbjct: 442 QEEKMQEEERIREREKKMRE-------------EEETMREQEEKMQKQEENMWEQEEKEW 488
Query: 377 EANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTED 436
+ R + + + E+ + + + K+ QE G + EK E+ +
Sbjct: 489 QQQRLPEQKEKLWEQEKMQEQEEKIWEQE---EKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 437 GGEFEEGASENNAKESSPEKEAEEGCPEKES-----EEGCPKRGFEGSCSQKESEEGNPV 491
E EE + K E+ E+ E+E EE + +K EE +
Sbjct: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
Query: 492 RGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES--------EEDD 543
R EE ++E K + + E + +++ E EE++ +E E+ +
Sbjct: 606 REQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKE 665
Query: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGS----EKELHENVLDKELEENDSEN 599
E ++ +++ ++ E+ +E+ +EK E+ ++++ E +E E+ E
Sbjct: 666 KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
Query: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEE-----EEDTYEKVFDDESDEK--EDEEYAD 652
E + EK+ ++E +E +E+ E+EE EE +E+ E EK E E+ +
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
Query: 653 EKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVE--DADEKLFEDDD----SNEKL 706
++ + ++K + + + EE ++E G+E + +EK++ ++ EK+
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKM 845
Query: 707 FDEEEDSSEKL 717
+ +EE EK+
Sbjct: 846 WGQEEKMEEKM 856
Score = 60.5 bits (145), Expect = 6e-09
Identities = 76/346 (21%), Positives = 138/346 (39%), Gaps = 36/346 (10%)
Query: 345 QAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSE 404
+ WD + EE RERE+++R E + E + E+
Sbjct: 577 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE------ 630
Query: 405 HPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAE-EGCP 463
KM QE EK +E+ E E EE E EK E E
Sbjct: 631 ----EKMQEQE------------EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 674
Query: 464 EKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESED 523
E+E + ++ +E +K+++E +E ++ES ++ K EE + +E E+
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 524 DLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKEL 583
+ +E EE E+E + E++ + E+ +E+ L + ++ +++
Sbjct: 735 KM-----------QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783
Query: 584 HENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFDDES 642
E E EE + E EK+ +E R +E +EE+ EK++ E
Sbjct: 784 QEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 843
Query: 643 DEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKE 688
EE +EK ++ ++K E + + EE +++E G+E
Sbjct: 844 KMWGQEEKMEEK-MQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Score = 48.1 bits (113), Expect = 3e-05
Identities = 79/381 (20%), Positives = 155/381 (40%), Gaps = 29/381 (7%)
Query: 347 WDGTTDYQVEETSREREERLRGWEAFLNAPEA----NRGLRRSDSVSASERAGPSRARHF 402
W+ + EE E+EE++R E + + + D + E + +
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 403 --SEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEE 460
E K QE T E+ +E++ + E EE ++ ++E +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
Query: 461 GCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
EK E+ + E ++E + E E K+K +++ K
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE-------KM 673
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFE-------ENGLEKD 573
E + +E EE++ ++ E+ E+E EK E+ S RE E E E++
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 574 LDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFD-EDSDEKEEEED 632
+ E+++ E ++E+ E + + E E+ E+ E E+ ++ E E+E+ +
Sbjct: 734 EKMQEQEEKMQEQ--EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
Query: 633 TYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLF--EESDDKEDEDADGKEVE 690
EK+ D E + EE + + ++ + +EK++ EE ++E G+E E
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQE-E 850
Query: 691 DADEKLFEDDDSNEKLFDEEE 711
+EK+ EK+ ++EE
Sbjct: 851 KMEEKM---QGQEEKMREQEE 868
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/219 (19%), Positives = 103/219 (47%), Gaps = 13/219 (5%)
Query: 504 KKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSER 563
++ L + N + E N E +E++ P ESE+ + + E + +
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKL-PLAESEKSEIQLNVKELKRKLERAKFLLP 263
Query: 564 EFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFED------DGSEKVLDEEGSE 617
+ + N L++++ + E E + K+ E+ + + + EK+ +E
Sbjct: 264 QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL 323
Query: 618 REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD 677
RE +++ E+E+E +++ + E +E EE E+ + +++ + +E+L+E+
Sbjct: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
Query: 678 DKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
+++ +++ D +E+++E D E+L ++EE E+
Sbjct: 384 QMREQE---QKMRDQEERMWEQD---ERLREKEERMREQ 416
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 73.2 bits (178), Expect = 9e-13
Identities = 75/345 (21%), Positives = 156/345 (45%), Gaps = 35/345 (10%)
Query: 399 ARHFSEHPSTSKMNAQETATGMAFEEPIDEKK--FEKTEDGGEFEEGASENNAKESSPEK 456
A+ S+ S +A++ + + D+KK +K + + E G S++ K++ +K
Sbjct: 292 AKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDK 351
Query: 457 EAEEGCPEKESEEGCPKRGF--EGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEE 514
+ + +K+ + P+ G ++ N + S+ D KK++KK T D E
Sbjct: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
Query: 515 NGLAKESEDDLNKESEEEVGPTKESEEDDSEK-ESDEDCSEKQSEDGSEREFEENGLEKD 573
+KES+ D K+ ++ K+S ++D E ++D SE + + ++ E+ G +KD
Sbjct: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDAD---SEPKGDSKKGKKDEKKG-KKD 467
Query: 574 LDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDT 633
++ +K+ +N E+ E+D E + + EK +GS+++ +D+ +
Sbjct: 468 SKKDDKKKDAKKNAESTEM-ESDLELKKDKKHSKEK----KGSKKDIKKDARK------- 515
Query: 634 YEKVFDDESDEKEDEEYADEKGLEAADK-KAEEGDADEKLFEESDDKEDEDADGKEVEDA 692
D ES + E +E + + G + + K K + +++E L++ K+ +++DG
Sbjct: 516 -----DTESTDAEFDE-SSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSK 569
Query: 693 DEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGP 737
E L E S + F++ E+ + G E P
Sbjct: 570 MEGL-------ESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKP 607
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/278 (21%), Positives = 126/278 (45%), Gaps = 19/278 (6%)
Query: 445 SENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESK 504
S+NN+K S + +K++++ K ++S++ + + KK+ K
Sbjct: 269 SQNNSKNYSLKYTKYT---KKDTKKNAKK---SSDAESEDSKDAKKDSKKVKKNVKKDDK 322
Query: 505 KKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDE--DCSEKQSEDGSE 562
KK +K D E D K+++++ K+ ++DD +K++ + + ++ +S D +
Sbjct: 323 KKDVKKDTESTDAESGDSKDERKDTKKD---KKKLKKDDKKKDTKKYPESTDTESGDAKD 379
Query: 563 REFEENGLEKDLDEEGSEKELHENVL----DKELEENDSENSEFEDDGSEKVLDEEGSER 618
+ L+K + +K+ + + ELE +S+ E +D K D + S +
Sbjct: 380 ARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT-DNKKSVK 438
Query: 619 EFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD 678
+E +D E + +K DE K+D + D+K + A K AE + + L + D
Sbjct: 439 NDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK--KDAKKNAESTEMESDLELKKDK 496
Query: 679 KEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
K ++ G + +D + +D +S + FDE + K
Sbjct: 497 KHSKEKKGSK-KDIKKDARKDTESTDAEFDESSKTGFK 533
Score = 63.9 bits (154), Expect = 5e-10
Identities = 67/300 (22%), Positives = 137/300 (45%), Gaps = 28/300 (9%)
Query: 427 DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE 486
D KK K E E+ +AK+ S K+ ++ + + ++ K +S+
Sbjct: 287 DTKKNAKKSSDAESEDS---KDAKKDS--KKVKKNVKKDDKKKDVKKDTESTDAESGDSK 341
Query: 487 EGNPVRGSEEDSPKKESKKKTLKNDCE----ENGLAKESEDDLNKESEEEVGPTKESEED 542
+ ++ KK+ KKK K E E+G AK++ +D K S+ D
Sbjct: 342 DERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLK-------KASKND 394
Query: 543 DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEF 602
D +K++ + SE SE E +E+ ++ D++ S+ + ++V K EE+ +SE
Sbjct: 395 DKKKDAKKITFSTDSE--SELESKESQKDEKKDKKDSKTDNKKSV--KNDEESTDADSEP 450
Query: 603 EDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK 662
+ D + DE+ +++ +D +K+ +++ + + + K+D++++ EK D K
Sbjct: 451 KGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIK 510
Query: 663 AEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
D + ES D E +++ + + + D +S E L+ + ++K D+SD
Sbjct: 511 -----KDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLY---KPGAKKKIDESD 562
Score = 63.2 bits (152), Expect = 9e-10
Identities = 72/374 (19%), Positives = 157/374 (41%), Gaps = 75/374 (20%)
Query: 409 SKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESE 468
SK AT ++ ++EK + E + + EN ++S K + E PE ++
Sbjct: 131 SKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHEN--EQSKKSKSSSETNPESQNS 188
Query: 469 EGCPKRGFEGSCSQKESEEGNPVRGSE------EDSPKKESKKKTLKND-----CEENGL 517
+ K +CSQK+ ++ + + +++PKK+ K+ ND C EN L
Sbjct: 189 KTVSK-----NCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSL 243
Query: 518 -------AKESEDDL------------NKESEEEVGPTKESEEDDSEKESDEDCSEKQSE 558
+S+D+ N + TK +++D K++ + S+ +SE
Sbjct: 244 NVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDT--KKNAKKSSDAESE 301
Query: 559 DGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVL---DEEG 615
D + + + ++K++ ++ +K++ ++ + E DS++ + +K L D++
Sbjct: 302 DSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKK 361
Query: 616 SEREFDEDSDEK---------------------EEEEDTYEKVFDDESD------EKEDE 648
+++ E +D + ++++D + F +S+ E + +
Sbjct: 362 DTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKD 421
Query: 649 EYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFD 708
E D+K + +KK+ + D EES D + E + DEK + D +
Sbjct: 422 EKKDKKDSKTDNKKSVKND------EESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKK 475
Query: 709 EEEDSSEKLFDDSD 722
+ + ++E +SD
Sbjct: 476 DAKKNAESTEMESD 489
Score = 53.9 bits (128), Expect = 5e-07
Identities = 56/247 (22%), Positives = 105/247 (42%), Gaps = 26/247 (10%)
Query: 483 KESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKES-EDDLNKESEEEVGPTKESEE 541
K+ + G P+ KK+SKKK N +K+ E+ +++E + P K S E
Sbjct: 119 KDEKGGTPL--------KKDSKKKG--GSYATNPESKQIVEEKTKRQNEADKTPLKSSHE 168
Query: 542 DDSEKESDEDCSEKQSEDGSEREFEENGLEKDL-DEEGSEKELHENVLDKELEENDSENS 600
++ K+S + SE E + + +N +KD D + S+K E + K + D + S
Sbjct: 169 NEQSKKS-KSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRS 227
Query: 601 EFEDDGSEKVLDEEGSEREF---DEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
+ +D ++ E +F SD++ D + + + + + +Y +
Sbjct: 228 KTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKD 287
Query: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
+ DA ES+D +D D K+V +K + DD + + + E + +
Sbjct: 288 TKKNAKKSSDA------ESEDSKDAKKDSKKV----KKNVKKDDKKKDVKKDTESTDAES 337
Query: 718 FDDSDER 724
D DER
Sbjct: 338 GDSKDER 344
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 72.8 bits (177), Expect = 1e-12
Identities = 80/365 (21%), Positives = 148/365 (40%), Gaps = 31/365 (8%)
Query: 354 QVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNA 413
Q EE +EE+++ WE + E R E+ R + KM
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKI---REQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 414 QETATGMAFEEP--IDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC 471
QE E+ ++E +EK E E EE E EK EE EK E+
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE---EKIREQ-- 408
Query: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEE 531
+++ +E R E+ ++E ++ K + E E +E +
Sbjct: 409 ---------EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459
Query: 532 EVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKE 591
E EE E+E EK E R+ EE ++ E+++ E
Sbjct: 460 EQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ----- 514
Query: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
EE E + EK+ ++E RE +E E+EE+ E+ ++ + EE
Sbjct: 515 -EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 652 DEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEE 711
E+ + ++K + + +EK++E+ + +++ + +++ +EK++E + EK+ ++EE
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIREQE---EMMQEQEEKMWEQE---EKMCEQEE 627
Query: 712 DSSEK 716
E+
Sbjct: 628 KMQEQ 632
Score = 72.0 bits (175), Expect = 2e-12
Identities = 85/409 (20%), Positives = 181/409 (44%), Gaps = 38/409 (9%)
Query: 351 TDYQVEETSREREERLRGWEAF-----LNAPEANRGLRRSDSVSASERAGPSRARHFSEH 405
TD +++E + + +E+L+ E+ LN E R L R+ + ++ E
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274
Query: 406 PSTS-KMNAQ--ETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC 462
S S K+ AQ E + +EK + + E E+EE E K E++ E
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 463 PEKESEEGCPKRGFEGSCSQKES--EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
+ +E E Q+E E+ +R EE +KE K + L+ E +E
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIRE 394
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSE 580
E+ ++ EE++ ++ +E +++ E+ +Q E E+E + E+ + E+
Sbjct: 395 QEE--KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 581 KELHENVLDKELEENDSENSEFED--------DGSEKVLDEEGS-----EREFDEDSDEK 627
+E + +E+ + + E E+ EK+ +E E+ D++ +
Sbjct: 453 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIR 512
Query: 628 EEEEDTY---EKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD------- 677
E+EE + EK+ + E +E EE E+ +++ + G+ +EK+ E+
Sbjct: 513 EQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEK 572
Query: 678 --DKEDEDADGKE-VEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
++E++ + KE + + +EK++E ++ + + ++ EK+++ ++
Sbjct: 573 IREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/318 (22%), Positives = 135/318 (42%), Gaps = 48/318 (15%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
++ + ED GE ++ + ++ S +++ EK E+ +KE E
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKK------HARVKEKEREHE 121
Query: 489 NPVRGSEE-DSPKKESKKKTLKNDCEENGLAKESE-DDLNKESEEEVGPTKESEEDDSEK 546
R EE D ++E +++ + E+ + + L ++ E E ++ +E +K
Sbjct: 122 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 181
Query: 547 ESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH-------------------ENV 587
E + E++ E + RE + D K H + V
Sbjct: 182 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 241
Query: 588 LDKELEENDS-------ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFD 639
++++EE D +SE + +E E GS E +E+ +E+EEEE T E+ +
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 301
Query: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE-----------DADGKE 688
+E +E+E+EE EA+++ AEE E+ E +++E+E D D E
Sbjct: 302 EEEEEEEEEEETGSNSEEASEQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGE 359
Query: 689 VEDADEKLFEDDDSNEKL 706
E+A+E++ E + L
Sbjct: 360 SEEAEEEVGEGTPQSSAL 377
Score = 67.0 bits (162), Expect = 6e-11
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 38/269 (14%)
Query: 377 EANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTE 435
+ R ++ V ER R RH E + ++ MA E E+ + E+ E
Sbjct: 102 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 161
Query: 436 DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC------------------------ 471
E E E KE +KE E E+ E
Sbjct: 162 RKRERERKMREQQ-KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 220
Query: 472 -------PKRGFEGSCSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
P+ FE +K E E + +D E K + ++ E+G E
Sbjct: 221 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 280
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSE 580
E++ +E EEE ++ESEE++ E+E +E+ + SE+ SE+ EE E+ ++E E
Sbjct: 281 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340
Query: 581 KELHENVLDKELEENDS-ENSEFEDDGSE 608
E H V+ + + DS E+ E E++ E
Sbjct: 341 NENHLLVVPESRFDRDSGESEEAEEEVGE 369
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 72.4 bits (176), Expect = 1e-12
Identities = 70/321 (21%), Positives = 139/321 (43%), Gaps = 45/321 (14%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEG---CPKRGFEGSCSQKES 485
++ + ED GE ++ + ++ S +++ EK E+ ++ E ++
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 486 EEGNPVRGSEEDSPKKESKKKTLKNDCEENG--LAKESEDDLNKESEEEVGPTKESEEDD 543
EE + R E ++E ++ + + +G L ++ + L ++ E E ++ +E
Sbjct: 128 EEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQR 187
Query: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH------------------- 584
+KE + E++ E + RE + D K H
Sbjct: 188 EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGR 247
Query: 585 ENVLDKELEENDS-------ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEK 636
+ V ++++EE D +SE + +E E GS E +E+ +E+EEEE T E+
Sbjct: 248 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 307
Query: 637 VFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE-----------DAD 685
++E +E+E+EE EA+++ AEE E+ E +++E+E D D
Sbjct: 308 SEEEEEEEEEEEEETGSNSEEASEQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRD 365
Query: 686 GKEVEDADEKLFEDDDSNEKL 706
E E+A+E++ E + L
Sbjct: 366 SGESEEAEEEVGEGTPQSSAL 386
Score = 60.5 bits (145), Expect = 6e-09
Identities = 74/312 (23%), Positives = 116/312 (37%), Gaps = 31/312 (9%)
Query: 377 EANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK------- 429
+ R ++ V ER R RH E + ++ MA E E+
Sbjct: 102 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCL 161
Query: 430 ---KFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE 486
+ E+ E E E E KE +KE E E+ E + + +E
Sbjct: 162 FRDRLEQLERKRERERKMREQQ-KEQREQKERERRAEERRKEREARREVSAHHRTMREDY 220
Query: 487 EG---------NPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKE----SEEEV 533
+P R E + +K + EE L + +D + E S E
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESS 280
Query: 534 GPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGS-EKELHENVLDKEL 592
S ++ E+E +E+ E + + SE E EE E++ +E GS +E E ++
Sbjct: 281 SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE--EEEEEETGSNSEEASEQSAEEVS 338
Query: 593 EENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
EE SE+ E E++ V+ E FD DS E EE E+ + S E + D
Sbjct: 339 EEEMSEDEERENENHLLVVPES----RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 394
Query: 653 EKGLEAADKKAE 664
L + K E
Sbjct: 395 SPALSPIELKQE 406
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/202 (22%), Positives = 84/202 (41%), Gaps = 16/202 (7%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
++ RE++ER R E EA R + + + +A H+S P E
Sbjct: 183 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 242
Query: 416 TATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRG 475
G +P+ E+K E+ + + ++ + S+ AE G +E EE +
Sbjct: 243 LGDG---RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 299
Query: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEE--- 532
EGS S++ EE EE+ ++E + + + E + SE++++++ E E
Sbjct: 300 EEGSTSEESEEE-------EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 352
Query: 533 ---VGPTKESEEDDSEKESDED 551
V P + D E E E+
Sbjct: 353 HLLVVPESRFDRDSGESEEAEE 374
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/318 (22%), Positives = 135/318 (42%), Gaps = 48/318 (15%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
++ + ED GE ++ + ++ S +++ EK E+ +KE E
Sbjct: 34 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKK------HARVKEKEREHE 87
Query: 489 NPVRGSEE-DSPKKESKKKTLKNDCEENGLAKESE-DDLNKESEEEVGPTKESEEDDSEK 546
R EE D ++E +++ + E+ + + L ++ E E ++ +E +K
Sbjct: 88 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 147
Query: 547 ESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH-------------------ENV 587
E + E++ E + RE + D K H + V
Sbjct: 148 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 207
Query: 588 LDKELEENDS-------ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFD 639
++++EE D +SE + +E E GS E +E+ +E+EEEE T E+ +
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 267
Query: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE-----------DADGKE 688
+E +E+E+EE EA+++ AEE E+ E +++E+E D D E
Sbjct: 268 EEEEEEEEEEETGSNSEEASEQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGE 325
Query: 689 VEDADEKLFEDDDSNEKL 706
E+A+E++ E + L
Sbjct: 326 SEEAEEEVGEGTPQSSAL 343
Score = 67.0 bits (162), Expect = 6e-11
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 38/269 (14%)
Query: 377 EANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTE 435
+ R ++ V ER R RH E + ++ MA E E+ + E+ E
Sbjct: 68 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 127
Query: 436 DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC------------------------ 471
E E E KE +KE E E+ E
Sbjct: 128 RKRERERKMREQQ-KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 186
Query: 472 -------PKRGFEGSCSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKE 520
P+ FE +K E E + +D E K + ++ E+G E
Sbjct: 187 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 246
Query: 521 SEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSE 580
E++ +E EEE ++ESEE++ E+E +E+ + SE+ SE+ EE E+ ++E E
Sbjct: 247 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 306
Query: 581 KELHENVLDKELEENDS-ENSEFEDDGSE 608
E H V+ + + DS E+ E E++ E
Sbjct: 307 NENHLLVVPESRFDRDSGESEEAEEEVGE 335
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 72.0 bits (175), Expect = 2e-12
Identities = 68/316 (21%), Positives = 136/316 (43%), Gaps = 45/316 (14%)
Query: 429 KKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEG 488
++ + ED GE ++ + ++ S +++ EK E+ R ++E E
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHAR-----VKEREHERR 122
Query: 489 NPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKES 548
R ++ + ++ ++K + E + ++ + L ++ E E ++ +E +KE
Sbjct: 123 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 182
Query: 549 DEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH-------------------ENVLD 589
+ E++ E + RE + D K H + V +
Sbjct: 183 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 242
Query: 590 KELEENDS-------ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEE-DTYEKVFDDE 641
+++EE D +SE + +E E GS E +E+ +E+EEEE T E+ ++E
Sbjct: 243 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 302
Query: 642 SDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE-----------DADGKEVE 690
+E+E+EE EA+++ AEE E+ E +++E+E D D E E
Sbjct: 303 EEEEEEEEETGSNSEEASEQSAEE--VSEEEMSEDEERENENHLLVVPESRFDRDSGESE 360
Query: 691 DADEKLFEDDDSNEKL 706
+A+E++ E + L
Sbjct: 361 EAEEEVGEGTPQSSAL 376
Score = 68.2 bits (165), Expect = 3e-11
Identities = 88/376 (23%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 423 EEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQ 482
+E + EKK K E EE A K S + E E + C + S +
Sbjct: 14 DEILQEKKRRK-----EQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYR 68
Query: 483 KESEEGNPVRGSEEDS-----PKKESKKKTLKNDCEE-------NGLAKESEDDLNKESE 530
+E + RG E+DS P++ S+K+ + + +E + KE E + K
Sbjct: 69 REDSMED--RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHR 126
Query: 531 EEVGPTK---------ESEEDDSEKESD----------------EDCSEKQSEDGSEREF 565
EE + E + S +E D E E++ + ER
Sbjct: 127 EEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRA 186
Query: 566 EENGLEKDLDEEGS--EKELHENVLDKELEENDSEN------SEFE-DDGSEKVLDEEGS 616
EE E++ E S + + E+ DK + S + FE DG + V +E+
Sbjct: 187 EERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME 246
Query: 617 EREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEES 676
ER+ D + + E K ES E ++E+ E +++ E ++E EE
Sbjct: 247 ERDLLSDLQDISDSE---RKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 303
Query: 677 DDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSS-------EKLFD----DSDERG 725
+++E+E+ G E+A E+ E+ E DEE ++ E FD +S+E
Sbjct: 304 EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 363
Query: 726 TLGGFGSVEEGPLSTG 741
G G+ + L+ G
Sbjct: 364 EEVGEGTPQSSALTEG 379
Score = 65.5 bits (158), Expect = 2e-10
Identities = 64/254 (25%), Positives = 102/254 (40%), Gaps = 38/254 (14%)
Query: 392 ERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEK-KFEKTEDGGEFEEGASENNAK 450
ER R RH E + ++ MA E E+ + E+ E E E E K
Sbjct: 116 EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQ-K 174
Query: 451 ESSPEKEAEEGCPEKESEEGC-------------------------------PKRGFEGS 479
E +KE E E+ E P+ FE
Sbjct: 175 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 234
Query: 480 CSQK----ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
+K E E + +D E K + ++ E+G E E++ +E EEE
Sbjct: 235 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 294
Query: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
++ESEE++ E+E +E+ + SE+ SE+ EE E+ ++E E E H V+ + +
Sbjct: 295 SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDR 354
Query: 596 DS-ENSEFEDDGSE 608
DS E+ E E++ E
Sbjct: 355 DSGESEEAEEEVGE 368
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/202 (22%), Positives = 84/202 (41%), Gaps = 16/202 (7%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
++ RE++ER R E EA R + + + +A H+S P E
Sbjct: 173 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 232
Query: 416 TATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRG 475
G +P+ E+K E+ + + ++ + S+ AE G +E EE +
Sbjct: 233 LGDG---RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 289
Query: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEE--- 532
EGS S++ EE EE+ ++E + + + E + SE++++++ E E
Sbjct: 290 EEGSTSEESEEE-------EEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 342
Query: 533 ---VGPTKESEEDDSEKESDED 551
V P + D E E E+
Sbjct: 343 HLLVVPESRFDRDSGESEEAEE 364
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 71.2 bits (173), Expect = 3e-12
Identities = 85/402 (21%), Positives = 176/402 (43%), Gaps = 32/402 (7%)
Query: 351 TDYQVEETSREREERLRGWEAF-----LNAPEANRGLRRSDSVSASERAGPSRARHFSEH 405
TD +++E + + +E+L+ E+ LN E R L R+ + ++ E
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274
Query: 406 PSTS-KMNAQ--ETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC 462
S S K+ AQ E + +EK + + E E+EE E K E++ E
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 463 PEKESEEGCPKRGFEGSCSQKES--EEGNPVRGSEEDSPKKESKKKTLKNDC-EENGLAK 519
+ +E E Q+E E+ +R EE +KE K + + E+ +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 520 ESEDDLNKESEEEVGPTKESEED---DSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE 576
E E+ ++++ + K EE+ + EK +++ + E+ RE EE E++
Sbjct: 395 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-KIREQEEKIREQEKKM 453
Query: 577 EGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEK 636
E+++HE +E E+ + + + EK+ ++E R+ ++ +++E+ EK
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQE--EKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Query: 637 VFDDESDEKEDEEYADE------------KGLEAADKKAEEGDADEKLFEESDDKEDED- 683
V+ E +E EE E + E ++ E+ EK++EE +E ED
Sbjct: 512 VWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571
Query: 684 --ADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
+++ + +EK++ ++ + ++ ++ EK++ ++
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK 613
Score = 69.3 bits (168), Expect = 1e-11
Identities = 92/380 (24%), Positives = 166/380 (43%), Gaps = 31/380 (8%)
Query: 345 QAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSE 404
Q W+ Q EE RE+EE++R E +RR + + E+ R +
Sbjct: 310 QEWEEKIQEQ-EEKIREQEEKIR---------EQEEKMRRQEEMMW-EKEEKMRRQEEMM 358
Query: 405 HPSTSKMNAQETATGMAFEEPI--DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC 462
KM QE E+ +E +EK E E EE E EK EE
Sbjct: 359 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE-- 416
Query: 463 PEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESE 522
EK E+ KR + + ++ E+ +R EE +E +KK + + + + K E
Sbjct: 417 -EKIREQ--EKRQEQEAKMWRQEEK---IREQEEKI--REQEKKMWRQEEKIHEQEKIRE 468
Query: 523 DDLNKESEE---EVGPTKESEEDDSEKESDEDCSEK--QSEDGSEREFEENGLEKDLDEE 577
++ +E EE + E EE +KE + EK + E+ R+ E+ +++ E
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 578 GSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV 637
EK + +E EE E + + EK+ +EE + + D+ ++E+ + EKV
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQ--EKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586
Query: 638 FDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD-KEDEDADGKEVEDADEKL 696
+ E +E EE E+ + ++ + + +EK+ E+ + +E E+ ++ E E+
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQE 646
Query: 697 FEDDDSNEKLFDEEEDSSEK 716
+ + EK+ ++EE E+
Sbjct: 647 EKMGEQEEKMCEQEEKMQEQ 666
Score = 62.8 bits (151), Expect = 1e-09
Identities = 86/401 (21%), Positives = 165/401 (41%), Gaps = 52/401 (12%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
EE RE+EE++R E + E +RR + + E+ R + KM QE
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEK--MRRQEEMMW-EKEEKMRRQEEMMWEKEEKMRRQE 383
Query: 416 TATGMAFEE--PIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGC----------P 463
E+ ++EK E+ + + E+ E +E +E E
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 443
Query: 464 EKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESED 523
EK E+ E ++E R +E+ ++E K + + E E+
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 524 DLNKESE----------EEVGPTKESEE-----DDSEKESDEDCSEKQSEDGSEREFEEN 568
+ K+ E E+ +E EE ++ +E +E E++ E+ +EE
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE- 562
Query: 569 GLEKDLDEEGSEKELHENVLDKE-----LEENDSENSEFEDDGSEKVLDEEGSEREFDED 623
EK ++E E + ++E EE E E + EK+ +E RE +E
Sbjct: 563 --EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEE- 619
Query: 624 SDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD----DK 679
+ +E+E EK+ + E +E EE E+ + +++ + + +EK+ E+ + +
Sbjct: 620 --KIQEQE---EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 680 EDEDADGKEVEDADEKLFEDD----DSNEKLFDEEEDSSEK 716
E K++ + +EK+ E + + EK++++EE E+
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 715
Score = 62.0 bits (149), Expect = 2e-09
Identities = 82/377 (21%), Positives = 169/377 (44%), Gaps = 37/377 (9%)
Query: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
EE E+EE++R E ++ E R + + E+ R E +KM QE
Sbjct: 383 EEMMWEKEEKIRELEEKMHEQEKIR--EQEEKRQEEEKIREQEKRQEQE----AKMWRQE 436
Query: 416 TATGMAFEEPI--DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPK 473
EE I EKK + E+ +E E ++ E +E ++ E K
Sbjct: 437 EKIREQ-EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 474 RGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEE-- 531
+K E+ +R EE ++E K + + E +++ +E EE
Sbjct: 496 --------EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 532 -EVGPTKESEE--DDSEKESDEDCSEKQSEDGSERE---FEENGLEKDLDEEGSEKELHE 585
E E E+ ++ +++ ED +Q E E+E + + ++ +E+ E+E
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607
Query: 586 NVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEE-EDTYEKVFDDESDE 644
++++ E + + E E EK+ ++E RE +E + E+EE+ + EK+ + E
Sbjct: 608 WKQEEKIREQEEKIQEQE----EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 663
Query: 645 KEDEE--YADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDS 702
+E EE + E+ + +KK E +EK+ E+ + ++++ +++ + +EK+ E ++
Sbjct: 664 QEQEETMWRQEEKIREQEKKIRE--QEEKIREQEEMMQEQE---EKMWEQEEKMCEQEEK 718
Query: 703 NEKLFDEEEDSSEKLFD 719
++ ++ EK+++
Sbjct: 719 MQEQEEKMRRQEEKMWE 735
Score = 57.8 bits (138), Expect = 4e-08
Identities = 79/383 (20%), Positives = 159/383 (41%), Gaps = 40/383 (10%)
Query: 353 YQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPST---- 408
++ EE RE EE++ E E + + + E+ A+ + +
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQ---EEEKIREQEKRQEQEAKMWRQEEKIREQE 443
Query: 409 SKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESE 468
K+ QE E+ +++K + E E EE + +E E+E EK E
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ---EEKIHEQEEIWRQKEKMHE 500
Query: 469 EGCPKRGFEGSCSQKES---EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESE--- 522
+ R E ++E E+ +R EE ++E K + + E E E
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 523 -DDLNKESEEEVGPTKESEEDDSEK---------ESDEDCSEKQSEDGSEREFEENGLEK 572
++ +E E+++ +E + EK E +E E++ + + E EK
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 573 DLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEED 632
++E +E E + +E EE E E + EK+ ++E +E +E +E
Sbjct: 621 IQEQEEKIREQEEKI--REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE---- 674
Query: 633 TYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDA 692
EK+ + E +E EE E+ +++ + + +EK+ E+ + ++++ +++
Sbjct: 675 --EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE---EKMRRQ 729
Query: 693 DEKLFEDDDSNEKLFDEEEDSSE 715
+EK++E + +L +EE E
Sbjct: 730 EEKMWEQE---VRLRQQEEKMQE 749
Score = 35.8 bits (81), Expect = 0.15
Identities = 57/251 (22%), Positives = 105/251 (41%), Gaps = 21/251 (8%)
Query: 353 YQVEETSREREERLRG-----WEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPS 407
++ EE RE+EE++R W E R + + E+ R E
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQE--- 569
Query: 408 TSKMNAQETATGMAFEEPI---DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPE 464
KM QE EE + +EK E+ E E EE + K E++ +E E
Sbjct: 570 -DKMWRQEEKIREQ-EEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ-EE 626
Query: 465 KESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDD 524
K E+ R E ++E + G E K + +++T+ E+ +E E
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK---IREQEKK 683
Query: 525 LNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH 584
+ +E EE++ +E EE E+E E++ + E+ E+ + +E+ E+E+
Sbjct: 684 I-REQEEKI---REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Query: 585 ENVLDKELEEN 595
+++++E+
Sbjct: 740 LRQQEEKMQEH 750
Score = 32.0 bits (71), Expect = 2.2
Identities = 48/259 (18%), Positives = 104/259 (40%), Gaps = 28/259 (10%)
Query: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
F G Q S + ++ + ++ L + N + E + N + +E++
Sbjct: 173 FAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL-Q 231
Query: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
ESE+ + + E K+ + ++ + L+ + D G E + L ++EEN
Sbjct: 232 LVESEKSEIQLNVKE---LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 596 DSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADE-- 653
+ N EK+ +E +E++E E+EE+ +E EE E
Sbjct: 289 ELWN-RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI-------------REQEEKIREQE 334
Query: 654 ----KGLEAADKKAEEGDADEKLFEESDDK----EDEDADGKEVEDADEKLFEDDDSNEK 705
+ E +K E+ E++ E ++K E+ + +E E++ + + +
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 706 LFDEEEDSSEKLFDDSDER 724
+E+ EK+ + ++R
Sbjct: 395 ELEEKMHEQEKIREQEEKR 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.128 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,551,416
Number of Sequences: 37866
Number of extensions: 1928211
Number of successful extensions: 51481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 750
Number of HSP's successfully gapped in prelim test: 1313
Number of HSP's that attempted gapping in prelim test: 10392
Number of HSP's gapped (non-prelim): 14570
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.