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Search of human proteins with 121114283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121114283 polo-like kinase 4 [Homo sapiens]
(970 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121114283 polo-like kinase 4 [Homo sapiens] 1960 0.0
gi|41872374 polo-like kinase 3 [Homo sapiens] 228 2e-59
gi|93004081 polo-like kinase 2 [Homo sapiens] 219 7e-57
gi|21359873 polo-like kinase 1 [Homo sapiens] 205 2e-52
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 199 1e-50
gi|83776600 aurora kinase B [Homo sapiens] 191 4e-48
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 182 1e-45
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 182 1e-45
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 182 1e-45
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 179 1e-44
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 168 2e-41
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 167 3e-41
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 167 4e-41
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 167 4e-41
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 167 4e-41
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 167 4e-41
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 167 4e-41
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 166 7e-41
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 166 7e-41
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 166 7e-41
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 166 7e-41
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 166 7e-41
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 166 1e-40
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 166 1e-40
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 165 2e-40
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 1960 bits (5077), Expect = 0.0
Identities = 970/970 (100%), Positives = 970/970 (100%)
Query: 1 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE 60
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
Sbjct: 1 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE 60
Query: 61 VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI 120
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
Sbjct: 61 VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI 120
Query: 121 ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP 180
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
Sbjct: 121 ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP 180
Query: 181 EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD 240
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
Sbjct: 181 EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD 240
Query: 241 LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST 300
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
Sbjct: 241 LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST 300
Query: 301 SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV 360
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
Sbjct: 301 SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV 360
Query: 361 IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY 420
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY
Sbjct: 361 IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY 420
Query: 421 SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF 480
SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF
Sbjct: 421 SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF 480
Query: 481 GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ 540
GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ
Sbjct: 481 GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ 540
Query: 541 NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK 600
NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK
Sbjct: 541 NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK 600
Query: 601 PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA 660
PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA
Sbjct: 601 PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA 660
Query: 661 DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG 720
DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG
Sbjct: 661 DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG 720
Query: 721 ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL 780
ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL
Sbjct: 721 ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL 780
Query: 781 ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH 840
ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH
Sbjct: 781 ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH 840
Query: 841 SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT 900
SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT
Sbjct: 841 SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT 900
Query: 901 QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL 960
QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL
Sbjct: 901 QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL 960
Query: 961 MFSNPTPNFH 970
MFSNPTPNFH
Sbjct: 961 MFSNPTPNFH 970
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 228 bits (582), Expect = 2e-59
Identities = 106/253 (41%), Positives = 159/253 (62%), Gaps = 1/253 (0%)
Query: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
G LLGKG FA Y A TG A+K+I + + K +++ NE+++H L+H I+
Sbjct: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
Query: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
++FED++ +Y+ LE+C + K R E E R+++ QI++G+ YLH GILH
Sbjct: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEPEVRYYLRQILSGLKYLHQRGILH 183
Query: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
RDL L N +T NM +K+ DFGLA +L+ P ++ T+CGTPNY++PE+ R HG E+DV
Sbjct: 184 RDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADV 243
Query: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
WSLGC+ YTLL G PPF+T +K T + Y +P+ LS+ A+ L+ +LR +P DR
Sbjct: 244 WSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRP 303
Query: 255 SLSSVLDHPFMSR 267
S+ +L H F ++
Sbjct: 304 SIDQILRHDFFTK 316
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 219 bits (559), Expect = 7e-57
Identities = 104/250 (41%), Positives = 150/250 (60%), Gaps = 1/250 (0%)
Query: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
G +LGKG FA Y + A K+I + K +++ E+++H L H +++
Sbjct: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
Query: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
Y+YFED +Y++LE C M LK R K +E E R+++ QI++G+ YLH ILH
Sbjct: 145 FYHYFEDKENIYILLEYCSRRSMAHILKAR-KVLTEPEVRYYLRQIVSGLKYLHEQEILH 203
Query: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
RDL L N + M +K+ DFGLA +L+ + T+CGTPNY+SPE+ + HG ESD+
Sbjct: 204 RDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDI 263
Query: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
W+LGC+ YT+L+GRPPF+T +K T + A Y MPS L AK LI +L +NP DR
Sbjct: 264 WALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRP 323
Query: 255 SLSSVLDHPF 264
SL ++ H F
Sbjct: 324 SLDDIIRHDF 333
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 205 bits (521), Expect = 2e-52
Identities = 95/252 (37%), Positives = 155/252 (61%), Gaps = 1/252 (0%)
Query: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
G LGKG FA + T A K++ K + K +++ E+ IH L H ++
Sbjct: 56 GRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVG 115
Query: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
+ +FED+++V++VLE+C + K R K +E EAR+++ QI+ G YLH + ++H
Sbjct: 116 FHGFFEDNDFVFVVLELCRRRSLLELHKRR-KALTEPEARYYLRQIVLGCQYLHRNRVIH 174
Query: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
RDL L NL L ++ +KI DFGLAT+++ E+ TLCGTPNYI+PE+ ++ H E DV
Sbjct: 175 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDV 234
Query: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
WS+GC+ YTLL+G+PPF+T +K T ++ +Y +P ++ A LI ++L+ +P R
Sbjct: 235 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARP 294
Query: 255 SLSSVLDHPFMS 266
+++ +L+ F +
Sbjct: 295 TINELLNDEFFT 306
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 199 bits (505), Expect = 1e-50
Identities = 100/265 (37%), Positives = 158/265 (59%), Gaps = 3/265 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
+EDF++G LGKG F VY A + +A+K++ K + KAG+ +++ EV+I L+
Sbjct: 130 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LY YF D+ VYL+LE G + R L+ ++ F E ++ ++ + Y H
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ-KLSKFDEQRTATYITELANALSYCH 248
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
S ++HRD+ NLLL +KIADFG + P + TLCGT +Y+ PE+ H
Sbjct: 249 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMH 306
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+WSLG + Y L+G+PPF+ +T + T ++ ++ P F++ A+DLI +LL+
Sbjct: 307 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 366
Query: 249 NPADRLSLSSVLDHPFMSRNSSTKS 273
NP+ R L VL+HP+++ NSS S
Sbjct: 367 NPSQRPMLREVLEHPWITANSSKPS 391
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 191 bits (484), Expect = 4e-48
Identities = 96/261 (36%), Positives = 151/261 (57%), Gaps = 3/261 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I+DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L
Sbjct: 74 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 133
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LYNYF D +YL+LE GE+ + L+ F E M ++ ++Y H
Sbjct: 134 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCT-FDEQRTATIMEELADALMYCH 192
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
++HRD+ NLLL +KIADFG + P + T+CGT +Y+ PE+ H
Sbjct: 193 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMH 250
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+W +G + Y LL+G PPF++ + T ++V D + P+ + + A+DLI +LLR
Sbjct: 251 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH 310
Query: 249 NPADRLSLSSVLDHPFMSRNS 269
NP++RL L+ V HP++ NS
Sbjct: 311 NPSERLPLAQVSAHPWVRANS 331
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 182 bits (462), Expect = 1e-45
Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
++DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L+
Sbjct: 6 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 65
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LYNYF D+ VYL+LE GE+ + L+ K E + ++ + Y H
Sbjct: 66 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 124
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
++HRD+ NLLL +KIADFG + + P + T+CGT +Y+ PE+ +
Sbjct: 125 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 182
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+W +G + Y LL+G PPF++ + T +++ D P + + A+DLI +LLR
Sbjct: 183 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 242
Query: 249 NPADRLSLSSVLDHPFMSRNS 269
P +RL L+ +L HP++ +S
Sbjct: 243 QPLERLPLAQILKHPWVQAHS 263
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 182 bits (462), Expect = 1e-45
Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
++DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L+
Sbjct: 21 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LYNYF D+ VYL+LE GE+ + L+ K E + ++ + Y H
Sbjct: 81 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 139
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
++HRD+ NLLL +KIADFG + + P + T+CGT +Y+ PE+ +
Sbjct: 140 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 197
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+W +G + Y LL+G PPF++ + T +++ D P + + A+DLI +LLR
Sbjct: 198 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 257
Query: 249 NPADRLSLSSVLDHPFMSRNS 269
P +RL L+ +L HP++ +S
Sbjct: 258 QPLERLPLAQILKHPWVQAHS 278
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 182 bits (462), Expect = 1e-45
Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
++DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L+
Sbjct: 40 VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 99
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+IL LYNYF D+ VYL+LE GE+ + L+ K E + ++ + Y H
Sbjct: 100 HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 158
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
++HRD+ NLLL +KIADFG + + P + T+CGT +Y+ PE+ +
Sbjct: 159 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 216
Query: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
+ D+W +G + Y LL+G PPF++ + T +++ D P + + A+DLI +LLR
Sbjct: 217 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 276
Query: 249 NPADRLSLSSVLDHPFMSRNS 269
P +RL L+ +L HP++ +S
Sbjct: 277 QPLERLPLAQILKHPWVQAHS 297
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 179 bits (454), Expect = 1e-44
Identities = 139/483 (28%), Positives = 227/483 (46%), Gaps = 43/483 (8%)
Query: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71
+++ LGKG++ V RA +G VAIK I K + + ++ E++I L HP
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 131
I+ +Y FE+ + + +++E GE+ Y+ R + SE E RHF QI++ + Y H +G
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISER-RRLSERETRHFFRQIVSAVHYCHKNG 173
Query: 132 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIAT-RSAHGL 190
++HRDL L N+LL N NIKIADFGL + L + T CG+P Y SPEI R G
Sbjct: 174 VVHRDLKLENILLDDNCNIKIADFGL-SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGP 232
Query: 191 ESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNP 250
E D W+LG + YTL+ G PFD KN + ++ +Y P+ S +A+ LI +L NP
Sbjct: 233 EVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNP 291
Query: 251 ADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDS--------IDSGHATISTAITASSSTSI 302
R ++ + +H +++ + D + DS ID H ST + A + +
Sbjct: 292 DRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHR--STGLQADTEAKM 349
Query: 303 SGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQ 362
G + + + + K+K DF+ SG Q+ ++
Sbjct: 350 KG----LAKPTTSEVMLERQRSLKKSKKENDFAQSG-----------QDAVPESPSKL-- 392
Query: 363 DAEERPHSRYLRRAYSSDRSGTSN------SQSQAKTYTMER--CHSAEMLSVSKRSG-G 413
+ +RP +R+ S RS ++ + T+ ME+ C + +L S +
Sbjct: 393 -SSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVP 451
Query: 414 GENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQAL-SNHLCPGKTPFPFADPTPQ 472
G+ + S T I +++ S S ER ++++ L SN + P P + P P
Sbjct: 452 GKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP-SPPDPA 510
Query: 473 TET 475
T
Sbjct: 511 RVT 513
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 168 bits (426), Expect = 2e-41
Identities = 98/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A + TG EVA+K+IDK + + Q++ EV+I L
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILN 115
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 174
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + + K T CG+P Y +PE+ +
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN-KLDTFCGSPPYAAPELFQGKKY 233
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ +LL
Sbjct: 234 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLV 293
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP R SL ++ +M+
Sbjct: 294 LNPIKRGSLEQIMKDRWMN 312
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 167 bits (424), Expect = 3e-41
Identities = 98/269 (36%), Positives = 150/269 (55%), Gaps = 4/269 (1%)
Query: 8 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 67
+I +++ +GKG+FA V RA + T +VAIK+IDK + + + +++ EV+I L
Sbjct: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL-KKIFREVQIMKML 62
Query: 68 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 127
HP I+ LY E +YLV E GE+ +L + +E EAR QI+T + +
Sbjct: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFC 121
Query: 128 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 187
H I+HRDL NLLL N+NIKIADFG + L P + T CG+P Y +PE+
Sbjct: 122 HCRNIVHRDLKAENLLLDANLNIKIADFGFSN-LFTPGQLLKTWCGSPPYAAPELFEGKE 180
Query: 188 H-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 246
+ G + D+WSLG + Y L+ G PFD T++N +V+ + +P F+S E + LI +L
Sbjct: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHML 240
Query: 247 RRNPADRLSLSSVLDHPFMSRNSSTKSKD 275
+P RLS+ + H +M + + D
Sbjct: 241 VLDPNKRLSMEQICKHKWMKLGDADPNFD 269
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 167 bits (423), Expect = 4e-41
Identities = 97/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A I TG EVA+K+IDK + + + Q++ EV+I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLN 108
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 167
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y +PE+ +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN-KLDTFCGSPPYAAPELFQGKKY 226
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ + L
Sbjct: 227 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 286
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP+ R +L ++ +M+
Sbjct: 287 LNPSKRGTLEQIMKDRWMN 305
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 167 bits (423), Expect = 4e-41
Identities = 97/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A I TG EVA+K+IDK + + + Q++ EV+I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLN 108
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 167
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y +PE+ +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN-KLDTFCGSPPYAAPELFQGKKY 226
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ + L
Sbjct: 227 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 286
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP+ R +L ++ +M+
Sbjct: 287 LNPSKRGTLEQIMKDRWMN 305
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 167 bits (423), Expect = 4e-41
Identities = 97/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A I TG EVA+K+IDK + + + Q++ EV+I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLN 108
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 167
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y +PE+ +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN-KLDTFCGSPPYAAPELFQGKKY 226
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ + L
Sbjct: 227 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 286
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP+ R +L ++ +M+
Sbjct: 287 LNPSKRGTLEQIMKDRWMN 305
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 167 bits (423), Expect = 4e-41
Identities = 97/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A I TG EVA+K+IDK + + + Q++ EV+I L
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLN 108
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 167
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y +PE+ +
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN-KLDTFCGSPPYAAPELFQGKKY 226
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ + L
Sbjct: 227 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 286
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP+ R +L ++ +M+
Sbjct: 287 LNPSKRGTLEQIMKDRWMN 305
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 167 bits (423), Expect = 4e-41
Identities = 97/259 (37%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
I ++++ +GKG+FA V A I TG EVA+K+IDK + + + Q++ EV+I L
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL-QKLFREVRIMKVLN 75
Query: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
HP+I++L+ E +YLV+E GE+ YL + E EAR QI++ + Y H
Sbjct: 76 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 134
Query: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y +PE+ +
Sbjct: 135 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN-KLDTFCGSPPYAAPELFQGKKY 193
Query: 189 -GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLR 247
G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S + ++L+ + L
Sbjct: 194 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLI 253
Query: 248 RNPADRLSLSSVLDHPFMS 266
NP+ R +L ++ +M+
Sbjct: 254 LNPSKRGTLEQIMKDRWMN 272
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 166 bits (421), Expect = 7e-41
Identities = 99/263 (37%), Positives = 151/263 (57%), Gaps = 6/263 (2%)
Query: 1 MATCIGEK--IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 58
+A+C E+ I ++++ +GKG+FA V A I TG EVAIK+IDK + + Q++
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLF 101
Query: 59 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 118
EV+I L HP+I++L+ E +YL++E GE+ YL + E EAR
Sbjct: 102 REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFR 160
Query: 119 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 178
QI++ + Y H I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYA 219
Query: 179 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIE 237
+PE+ + G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 279
Query: 238 AKDLIHQLLRRNPADRLSLSSVL 260
++L+ + L NP R +L ++
Sbjct: 280 CENLLKRFLVLNPIKRGTLEQIM 302
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 166 bits (421), Expect = 7e-41
Identities = 99/263 (37%), Positives = 151/263 (57%), Gaps = 6/263 (2%)
Query: 1 MATCIGEK--IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 58
+A+C E+ I ++++ +GKG+FA V A I TG EVAIK+IDK + + Q++
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLF 101
Query: 59 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 118
EV+I L HP+I++L+ E +YL++E GE+ YL + E EAR
Sbjct: 102 REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFR 160
Query: 119 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 178
QI++ + Y H I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYA 219
Query: 179 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIE 237
+PE+ + G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 279
Query: 238 AKDLIHQLLRRNPADRLSLSSVL 260
++L+ + L NP R +L ++
Sbjct: 280 CENLLKRFLVLNPIKRGTLEQIM 302
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 166 bits (421), Expect = 7e-41
Identities = 99/263 (37%), Positives = 151/263 (57%), Gaps = 6/263 (2%)
Query: 1 MATCIGEK--IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 58
+A+C E+ I ++++ +GKG+FA V A I TG EVAIK+IDK + + Q++
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLF 101
Query: 59 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 118
EV+I L HP+I++L+ E +YL++E GE+ YL + E EAR
Sbjct: 102 REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFR 160
Query: 119 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 178
QI++ + Y H I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYA 219
Query: 179 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIE 237
+PE+ + G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 279
Query: 238 AKDLIHQLLRRNPADRLSLSSVL 260
++L+ + L NP R +L ++
Sbjct: 280 CENLLKRFLVLNPIKRGTLEQIM 302
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 166 bits (421), Expect = 7e-41
Identities = 99/263 (37%), Positives = 151/263 (57%), Gaps = 6/263 (2%)
Query: 1 MATCIGEK--IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 58
+A+C E+ I ++++ +GKG+FA V A I TG EVAIK+IDK + + Q++
Sbjct: 43 IASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLF 101
Query: 59 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 118
EV+I L HP+I++L+ E +YL++E GE+ YL + E EAR
Sbjct: 102 REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFR 160
Query: 119 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 178
QI++ + Y H I+HRDL NLLL +MNIKIADFG + + + K T CG+P Y
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYA 219
Query: 179 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIE 237
+PE+ + G E DVWSLG + YTL+ G PFD +K +V+ Y +P ++S +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 279
Query: 238 AKDLIHQLLRRNPADRLSLSSVL 260
++L+ + L NP R +L ++
Sbjct: 280 CENLLKRFLVLNPIKRGTLEQIM 302
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 166 bits (421), Expect = 7e-41
Identities = 97/263 (36%), Positives = 151/263 (57%), Gaps = 6/263 (2%)
Query: 1 MATCIGEK--IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 58
+A+C E+ + ++++ +GKG+FA V A I TG EVAIK+IDK + + + Q++
Sbjct: 46 IASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL-QKLF 104
Query: 59 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 118
EV+I L HP+I++L+ E +YLV+E GE+ YL + + E EAR
Sbjct: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFR 163
Query: 119 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 178
QI++ + Y H I+HRDL NLLL NIKIADFG + + + K T CG+P Y
Sbjct: 164 QIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG-SKLDTFCGSPPYA 222
Query: 179 SPEIATRSAH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIE 237
+PE+ + G E D+WSLG + YTL+ G PFD +K +V+ Y +P ++S +
Sbjct: 223 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTD 282
Query: 238 AKDLIHQLLRRNPADRLSLSSVL 260
+ ++ + L NPA R +L ++
Sbjct: 283 CESILRRFLVLNPAKRCTLEQIM 305
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 166 bits (420), Expect = 1e-40
Identities = 90/248 (36%), Positives = 138/248 (55%), Gaps = 5/248 (2%)
Query: 10 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 69
EDFK G +LG+GSF+ V A + T E AIK+++K+ + K V V E + +L H
Sbjct: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
Query: 70 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 129
P ++LY F+D +Y L NGE+ +Y++ ++ F E R + +I++ + YLH
Sbjct: 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTAEIVSALEYLHG 198
Query: 130 HGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKH---YTLCGTPNYISPEIATRS 186
GI+HRDL N+LL +M+I+I DFG A L P K + GT Y+SPE+ T
Sbjct: 199 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLS-PESKQARANSFVGTAQYVSPELLTEK 257
Query: 187 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 246
+ SD+W+LGC+ Y L+ G PPF K++ +Y+ P +A+DL+ +LL
Sbjct: 258 SACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLL 317
Query: 247 RRNPADRL 254
+ RL
Sbjct: 318 VLDATKRL 325
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 166 bits (420), Expect = 1e-40
Identities = 90/248 (36%), Positives = 138/248 (55%), Gaps = 5/248 (2%)
Query: 10 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 69
EDFK G +LG+GSF+ V A + T E AIK+++K+ + K V V E + +L H
Sbjct: 53 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 112
Query: 70 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 129
P ++LY F+D +Y L NGE+ +Y++ ++ F E R + +I++ + YLH
Sbjct: 113 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTAEIVSALEYLHG 171
Query: 130 HGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKH---YTLCGTPNYISPEIATRS 186
GI+HRDL N+LL +M+I+I DFG A L P K + GT Y+SPE+ T
Sbjct: 172 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLS-PESKQARANSFVGTAQYVSPELLTEK 230
Query: 187 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 246
+ SD+W+LGC+ Y L+ G PPF K++ +Y+ P +A+DL+ +LL
Sbjct: 231 SACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLL 290
Query: 247 RRNPADRL 254
+ RL
Sbjct: 291 VLDATKRL 298
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 165 bits (418), Expect = 2e-40
Identities = 97/255 (38%), Positives = 146/255 (57%), Gaps = 4/255 (1%)
Query: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71
+ + LGKG+FA V T EVAIK+IDK + A ++++ EV+I L HP
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-DAVNLEKIYREVQIMKMLDHPH 78
Query: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 131
I++LY E + +YLV E NGE+ YL N + +E+EAR QI++ + Y H
Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-LNESEARRKFWQILSAVDYCHGRK 137
Query: 132 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI-ATRSAHGL 190
I+HRDL NLLL NMNIKIADFG K E T CG+P Y +PE+ + G
Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFFK-SGELLATWCGSPPYAAPEVFEGQQYEGP 196
Query: 191 ESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNP 250
+ D+WS+G + Y L+ G PFD T+ +V+ + +P F+S + + LI ++L +P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
Query: 251 ADRLSLSSVLDHPFM 265
+ RL+++ + +H +M
Sbjct: 257 SKRLTIAQIKEHKWM 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,829,927
Number of Sequences: 37866
Number of extensions: 1742118
Number of successful extensions: 6809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 704
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 4196
Number of HSP's gapped (non-prelim): 1136
length of query: 970
length of database: 18,247,518
effective HSP length: 112
effective length of query: 858
effective length of database: 14,006,526
effective search space: 12017599308
effective search space used: 12017599308
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.