Guide to the Human Genome
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Search of human proteins with 24497577

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497577 aldo-keto reductase family 1, member A1 [Homo
sapiens]
         (325 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]    671   0.0  
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]     671   0.0  
gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]     325   3e-89
gi|223468663 aldo-keto reductase family 1, member B10 [Homo sapi...   313   1e-85
gi|122937516 aldo-keto reductase family 1, member B10-like [Homo...   301   4e-82
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]     271   6e-73
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]    270   1e-72
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]     270   1e-72
gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]     270   1e-72
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]    266   1e-71
gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]    257   1e-68
gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ...   249   2e-66
gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]         108   8e-24
gi|4504825 potassium voltage-gated channel, shaker-related subfa...    45   7e-05
gi|27436969 potassium voltage-gated channel, shaker-related subf...    45   7e-05
gi|27436964 potassium voltage-gated channel, shaker-related subf...    44   1e-04
gi|27436962 potassium voltage-gated channel, shaker-related subf...    44   1e-04
gi|27436966 potassium voltage-gated channel, shaker-related subf...    44   1e-04
gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]     43   3e-04
gi|27436971 potassium voltage-gated channel, shaker-related subf...    37   0.024
gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo s...    37   0.031
gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo s...    35   0.091
gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]     33   0.26 
gi|4504011 glutamate-cysteine ligase regulatory protein [Homo sa...    31   1.3  
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...    30   2.2  
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa...    30   2.9  
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa...    30   2.9  
gi|24308241 zinc finger and BTB domain containing 2 [Homo sapiens]     29   6.5  

>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score =  671 bits (1730), Expect = 0.0
 Identities = 325/325 (100%), Positives = 325/325 (100%)

Query: 1   MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60
           MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
Sbjct: 1   MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60

Query: 61  KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120
           KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
Sbjct: 61  KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120

Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180
           GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
Sbjct: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
           AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
Sbjct: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240

Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300
           YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
Sbjct: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300

Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325
           PMLTVDGKRVPRDAGHPLYPFNDPY
Sbjct: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325


>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score =  671 bits (1730), Expect = 0.0
 Identities = 325/325 (100%), Positives = 325/325 (100%)

Query: 1   MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60
           MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
Sbjct: 1   MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60

Query: 61  KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120
           KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER
Sbjct: 61  KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120

Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180
           GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP
Sbjct: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
           AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK
Sbjct: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240

Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300
           YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV
Sbjct: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300

Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325
           PMLTVDGKRVPRDAGHPLYPFNDPY
Sbjct: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325


>gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]
          Length = 316

 Score =  325 bits (833), Expect = 3e-89
 Identities = 161/325 (49%), Positives = 226/325 (69%), Gaps = 12/325 (3%)

Query: 3   ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62
           AS +LL+ G KMP++GLGTWKS PGQV  AVK A+ VGYRHIDCA +Y NE E+G A++E
Sbjct: 2   ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 61

Query: 63  DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
            +   + V REELF+ SKLW T H    V+ A +KTL+DL+L+YLDLYL+HWP  F+ G 
Sbjct: 62  KLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 120

Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180
             FP +  G +    T+  +TW A+E LV +GLV+A+G+SNFN  Q++ IL+   ++  P
Sbjct: 121 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 180

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
           AV Q+ECHPYL Q +LI +CQ++G+ VTAYSPLGS DR W  P++P LLE+P + A+A K
Sbjct: 181 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 240

Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300
           + ++ AQ+L+R+ +QR ++ IPKS+TP RI +N KVFDF  S ++M  L + N+NWR + 
Sbjct: 241 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR-VC 299

Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325
            +L+           H  YPF++ +
Sbjct: 300 ALLSC--------TSHKDYPFHEEF 316


>gi|223468663 aldo-keto reductase family 1, member B10 [Homo
           sapiens]
          Length = 316

 Score =  313 bits (803), Expect = 1e-85
 Identities = 153/297 (51%), Positives = 209/297 (70%), Gaps = 3/297 (1%)

Query: 3   ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62
           A+ V L T  KMP++GLGTWKS  G+VK AVK A+  GYRHIDCA +Y NE E+GEA++E
Sbjct: 2   ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 61

Query: 63  DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
            +   KAV RE+LF+ SKLW T      V  A  KTL DL+L YLD+YL+HWP  F+ GD
Sbjct: 62  KIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 120

Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180
           + FPK+  G        + + W+A+E LV +GLV+ALG+SNF+  QI+ +L+   ++  P
Sbjct: 121 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 180

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
              QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W  P++P LLE+P +  +A K
Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240

Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297
           + ++ AQ+L+R+ +QR VI IPKS+TP+RI++NI+VFDF  S EEM  + + N+NWR
Sbjct: 241 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWR 297


>gi|122937516 aldo-keto reductase family 1, member B10-like [Homo
           sapiens]
          Length = 316

 Score =  301 bits (772), Expect = 4e-82
 Identities = 148/297 (49%), Positives = 206/297 (69%), Gaps = 3/297 (1%)

Query: 3   ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62
           A+ V L T  KMP++GLGTW+S  G+VK AVK A+   YRHIDCA  Y N+ E+GEA++E
Sbjct: 2   ATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQE 61

Query: 63  DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
            +   KAV RE+LF+ SK+W T      V  A  KTL DL+L YLD+YL+HWP  F+ GD
Sbjct: 62  KIQE-KAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120

Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180
           + FPK+  G +      + + W+A+E LV +GLV+ALG+SNFN  QI+ +L+   ++  P
Sbjct: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240
              QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W  P++P LLE+P +  +A K
Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 240

Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297
           + ++ AQ+L+R+ +QR V  IPKS+TP+ I++NI+VFDF  S EEM  + + N+NWR
Sbjct: 241 HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWR 297


>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
          Length = 323

 Score =  271 bits (693), Expect = 6e-73
 Identities = 145/327 (44%), Positives = 214/327 (65%), Gaps = 16/327 (4%)

Query: 5   CVLLHTGQKMPLIGLGTWK-SEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61
           CV L+ G  MP++G GT+  +E  + KA  A K A+  G+RHID A +Y NE ++G A++
Sbjct: 7   CVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66

Query: 62  EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121
             +  G +V RE++F TSKLW   H PE V PAL ++L +LQL+Y+DLYL+H+P + + G
Sbjct: 67  SKIADG-SVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125

Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179
           +   PK+ +G I +D+     TW+A+E     GL +++G+SNFN RQ++ IL+   +  +
Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185

Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGS-SDRAWRDPDEPVLLEEPVVLALA 238
           P   QVECHPY  Q +L+  C+++ + + AYS LGS  +  W DP+ PVLLE+PV+ ALA
Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245

Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298
           +K+ R+PA I LR+Q+QR V+ + KS    RI QN++VF+F  + EEMK ++ LN+N RY
Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305

Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325
               LT+D       AG P YPF+D Y
Sbjct: 306 ----LTLD-----IFAGPPNYPFSDEY 323


>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score =  270 bits (691), Expect = 1e-72
 Identities = 144/327 (44%), Positives = 214/327 (65%), Gaps = 16/327 (4%)

Query: 5   CVLLHTGQKMPLIGLGTWK-SEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61
           CV L+ G  MP++G GT+  +E  + KA  AVK A+  G+ HID A +Y NE ++G A++
Sbjct: 7   CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66

Query: 62  EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121
             +  G +V RE++F TSKLW+  H PE V PAL ++L +LQL+Y+DLYL+H+P + + G
Sbjct: 67  SKIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125

Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179
           +   PK+ +G I +D+     TW+A+E     GL +++G+SNFN R ++ IL+   +  +
Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYK 185

Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGS-SDRAWRDPDEPVLLEEPVVLALA 238
           P   QVECHPY  Q +L+  C+++ + + AYS LGS  +  W DP+ PVLLE+PV+ ALA
Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245

Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298
           +K+ R+PA I LR+Q+QR V+ + KS    RI QN++VF+F  + EEMK ++ LN+N RY
Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305

Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325
               LT+D       AG P YPF+D Y
Sbjct: 306 ----LTLD-----IFAGPPNYPFSDEY 323


>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score =  270 bits (691), Expect = 1e-72
 Identities = 144/327 (44%), Positives = 214/327 (65%), Gaps = 16/327 (4%)

Query: 5   CVLLHTGQKMPLIGLGTWK-SEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61
           CV L+ G  MP++G GT+  +E  + KA  AVK A+  G+ HID A +Y NE ++G A++
Sbjct: 7   CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66

Query: 62  EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121
             +  G +V RE++F TSKLW+  H PE V PAL ++L +LQL+Y+DLYL+H+P + + G
Sbjct: 67  SKIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125

Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179
           +   PK+ +G I +D+     TW+A+E     GL +++G+SNFN R ++ IL+   +  +
Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYK 185

Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGS-SDRAWRDPDEPVLLEEPVVLALA 238
           P   QVECHPY  Q +L+  C+++ + + AYS LGS  +  W DP+ PVLLE+PV+ ALA
Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245

Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298
           +K+ R+PA I LR+Q+QR V+ + KS    RI QN++VF+F  + EEMK ++ LN+N RY
Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305

Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325
               LT+D       AG P YPF+D Y
Sbjct: 306 ----LTLD-----IFAGPPNYPFSDEY 323


>gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]
          Length = 326

 Score =  270 bits (690), Expect = 1e-72
 Identities = 145/331 (43%), Positives = 211/331 (63%), Gaps = 17/331 (5%)

Query: 2   AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57
           A+  + L  G  +P+IGLGT+   KS P G    +VK A+  GYRHID A IY NE E+G
Sbjct: 6   ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65

Query: 58  EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117
           EA++E +  GK V RE++F   KLW T H PE V P L +TL  LQL+Y+DLY++  P A
Sbjct: 66  EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124

Query: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
           F+ GD  +P++ +G   Y  ++   TW+A+EA    GLV++LG+SNFN RQ++ IL+   
Sbjct: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184

Query: 178 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 234
           +  +P   QVECHPY  Q +L+  CQ   + +TAYSPLG+S +  W +   P LL++ ++
Sbjct: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244

Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294
            +L ++Y ++ AQI+LR+ +QR V+ IPKS    RI +N ++FDF+ + EEMK + ALNK
Sbjct: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304

Query: 295 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325
           N R++  ++  D         HP YPF+D Y
Sbjct: 305 NVRFVELLMWRD---------HPEYPFHDEY 326


>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
          Length = 323

 Score =  266 bits (681), Expect = 1e-71
 Identities = 137/326 (42%), Positives = 210/326 (64%), Gaps = 16/326 (4%)

Query: 6   VLLHTGQKMPLIGLGTWKSEPGQVKAAV---KYALSVGYRHIDCAAIYGNEPEIGEALKE 62
           V L+ G  MP++G GT+         AV   K A+  G+RHID A +Y NE ++G A++ 
Sbjct: 8   VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67

Query: 63  DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122
            +  G +V RE++F TSKLW T   P+ V+PAL  +L  LQL+Y+DLYL+H+P A + G+
Sbjct: 68  KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126

Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180
            P PK+ +G + +D+     TW+ +E     GL +++G+SNFN RQ++ IL+   +  +P
Sbjct: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186

Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAE 239
              QVECHPYL Q++L+  C+++ + + A+S LG+   + W DP+ PVLLE+PV+ ALA+
Sbjct: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246

Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299
           K+ ++PA I LR+Q+QR V+ + KS    RI +NI+VF+F  + E+MK L+ LN+N+RY+
Sbjct: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306

Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDPY 325
           V    +D         HP YPF+D Y
Sbjct: 307 VMDFLMD---------HPDYPFSDEY 323


>gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]
          Length = 323

 Score =  257 bits (656), Expect = 1e-68
 Identities = 135/327 (41%), Positives = 205/327 (62%), Gaps = 16/327 (4%)

Query: 5   CVLLHTGQKMPLIGLGTWKS-EPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61
           CV L+ G  MP++G GT+   E  + KA    K A+  G+RHID A +Y NE ++G A++
Sbjct: 7   CVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66

Query: 62  EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121
             +  G +V RE++F TSKLW+T H PE V PAL  +L   QL+Y+DLYL+H P + + G
Sbjct: 67  SKIADG-SVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125

Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179
           +   P + +G + +D      TW+A+E     GL +++G+SNFN RQ++ IL+   +  +
Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185

Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALA 238
           P   QVECHPY  +++L+  C+++ + + AYS LGS  D+ W DP+ PVLLE+PV+ ALA
Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245

Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298
           +K+ R+PA I LR+Q+QR V+ + KS    RI QN++VF+F  + E+MK ++ L++N  Y
Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHY 305

Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325
                          A HP YP++D Y
Sbjct: 306 F---------NSDSFASHPNYPYSDEY 323


>gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo
           sapiens]
          Length = 320

 Score =  249 bits (637), Expect = 2e-66
 Identities = 137/333 (41%), Positives = 192/333 (57%), Gaps = 37/333 (11%)

Query: 14  MPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPRE 73
           +P +GL +WK+ PG+V  AVK A+  GYRH DCA  Y NE E+G  ++  +  G AV RE
Sbjct: 4   IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRRE 62

Query: 74  ELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD----------- 122
           +LF+ +KLW T H    VE A RK+L  L+L YLDLYL+HWP  F+              
Sbjct: 63  DLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELS 122

Query: 123 --------NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
                      P +    +    T + +TW+A+E LV  GLV+ +G+SNFN  Q++ +L+
Sbjct: 123 FCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 182

Query: 175 VASVR--PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEP 232
              +R  P   Q+ECHPYL Q  LI+ CQ+R + VTAY PLG S           L++ P
Sbjct: 183 KPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVD------LIDNP 236

Query: 233 VVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNAL 292
           V+  +A+++G+SPAQIL+R+Q+QR VI IP SITPS I +NI+VFDF  +  +M  + +L
Sbjct: 237 VIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 296

Query: 293 NKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325
           N+N R  +          P    H  YPF+  Y
Sbjct: 297 NRNLRLAM---------FPITKNHKDYPFHIEY 320


>gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]
          Length = 139

 Score =  108 bits (269), Expect = 8e-24
 Identities = 54/114 (47%), Positives = 79/114 (69%), Gaps = 4/114 (3%)

Query: 5   CVLLHTGQKMPLIGLGTWK-SEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61
           CV L+ G  MP++G GT+  +E  + KA  AVK A+  G+ HID A +Y NE ++G A++
Sbjct: 7   CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66

Query: 62  EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWP 115
             +  G +V RE++F TSKLW+  H PE V PAL ++L +LQL+Y+DLYL+H+P
Sbjct: 67  SKIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119


>gi|4504825 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 1 [Homo sapiens]
          Length = 367

 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 45  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 104

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 105 K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 160 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 200

Query: 175 VAS----VRPAVLQVECHPY 190
           VA       P   Q E H +
Sbjct: 201 VARQFNLTPPICEQAEYHMF 220


>gi|27436969 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 2 [Homo sapiens]
          Length = 353

 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 31  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 90

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 91  K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 145

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 146 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 186

Query: 175 VAS----VRPAVLQVECHPY 190
           VA       P   Q E H +
Sbjct: 187 VARQFNLTPPICEQAEYHMF 206


>gi|27436964 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 3 [Homo sapiens]
          Length = 401

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQVKAAV-----KYALSVGYRHIDCAAIYG---NEPEIGEALK 61
           +G ++  +GLGTW +  GQ+   V       A   G    D A +Y     E  +G  +K
Sbjct: 79  SGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIK 138

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
           +     K   R  L +T+KL W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 139 K-----KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 193

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
           P +                   +T  +E  +A+  ++ +G+    G S +++ +I +  S
Sbjct: 194 PDS-------------------NTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYS 234

Query: 175 VA----SVRPAVLQVECH 188
           VA     + P   Q E H
Sbjct: 235 VARQFNMIPPVCEQAEYH 252


>gi|27436962 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 2 [Homo sapiens]
          Length = 408

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQVKAAV-----KYALSVGYRHIDCAAIYG---NEPEIGEALK 61
           +G ++  +GLGTW +  GQ+   V       A   G    D A +Y     E  +G  +K
Sbjct: 86  SGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIK 145

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
           +     K   R  L +T+KL W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 146 K-----KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 200

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
           P +                   +T  +E  +A+  ++ +G+    G S +++ +I +  S
Sbjct: 201 PDS-------------------NTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYS 241

Query: 175 VA----SVRPAVLQVECH 188
           VA     + P   Q E H
Sbjct: 242 VARQFNMIPPVCEQAEYH 259


>gi|27436966 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 1 [Homo sapiens]
          Length = 419

 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 49/198 (24%), Positives = 82/198 (41%), Gaps = 43/198 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQVKAAV-----KYALSVGYRHIDCAAIYG---NEPEIGEALK 61
           +G ++  +GLGTW +  GQ+   V       A   G    D A +Y     E  +G  +K
Sbjct: 97  SGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIK 156

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
           +     K   R  L +T+KL W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 157 K-----KGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANR 211

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
           P +                   +T  +E  +A+  ++ +G+    G S +++ +I +  S
Sbjct: 212 PDS-------------------NTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYS 252

Query: 175 VA----SVRPAVLQVECH 188
           VA     + P   Q E H
Sbjct: 253 VARQFNMIPPVCEQAEYH 270


>gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]
          Length = 359

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 51/192 (26%), Positives = 79/192 (41%), Gaps = 30/192 (15%)

Query: 31  AAVKYALSVGYRHIDCAAIY--GNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKH-H 87
           AAV+  L  G+  +D A +Y  G    I   L   +G G    R ++   +  W+ K   
Sbjct: 58  AAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDC--RVKIATKANPWDGKSLK 115

Query: 88  PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147
           P+ V   L  +L  LQ   +DL+ +H P   + G                T  +ET  A 
Sbjct: 116 PDSVRSQLETSLKRLQCPQVDLFYLHAP---DHG----------------TPVEETLHAC 156

Query: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQ--VECHPYLAQNELIAHCQ 201
           + L  +G    LGLSN+ S ++ +I ++      + P V Q          + EL    +
Sbjct: 157 QRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLR 216

Query: 202 ARGLEVTAYSPL 213
             GL   AY+PL
Sbjct: 217 HFGLRFYAYNPL 228


>gi|27436971 potassium voltage-gated channel, shaker-related
           subfamily, beta member 3 [Homo sapiens]
          Length = 404

 Score = 37.0 bits (84), Expect = 0.024
 Identities = 48/198 (24%), Positives = 79/198 (39%), Gaps = 43/198 (21%)

Query: 10  TGQKMPLIGLGTWKSEPGQVK-AAVKYALSVGYRH----IDCAAIYG---NEPEIGEALK 61
           +G ++  +GLGTW +   Q+     +  L+V Y H     D A +Y     E  +G  LK
Sbjct: 86  SGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILK 145

Query: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114
                 K   R    +T+K+ W  +   E       +   LR +L  LQL Y+D+   + 
Sbjct: 146 -----SKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFAN- 199

Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174
                R D   P              +E  +A+  ++ +GL    G S + + +I +  S
Sbjct: 200 -----RSDPNCP-------------MEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYS 241

Query: 175 VAS----VRPAVLQVECH 188
           +A     + P   Q E H
Sbjct: 242 MARQFNLIPPVCEQAEHH 259


>gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo
           sapiens]
          Length = 331

 Score = 36.6 bits (83), Expect = 0.031
 Identities = 46/192 (23%), Positives = 76/192 (39%), Gaps = 30/192 (15%)

Query: 31  AAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG--PGKAVPREELFVTSKLW-NTKHH 87
           A  +  L  G+  ID A +Y +     E +   +G   G +  R ++   +  W      
Sbjct: 30  AVTRAFLERGHTEIDTAFLYSDGQS--ETILGGLGLRMGSSDCRVKIATKANPWIGNSLK 87

Query: 88  PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147
           P+ V   L  +L  LQ   +DL+ +H P      D+  P              +ET +A 
Sbjct: 88  PDSVRSQLETSLKRLQCPUVDLFYLHAP------DHSAP-------------VEETLRAC 128

Query: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQ--VECHPYLAQNELIAHCQ 201
             L  +G    LGLSN+ + ++ +I ++      + P V Q          + EL    +
Sbjct: 129 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLR 188

Query: 202 ARGLEVTAYSPL 213
             GL   AY+PL
Sbjct: 189 HFGLRFYAYNPL 200


>gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo
           sapiens]
          Length = 249

 Score = 35.0 bits (79), Expect = 0.091
 Identities = 47/206 (22%), Positives = 77/206 (37%), Gaps = 34/206 (16%)

Query: 31  AAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG--PGKAVPREELFVTSKLW-NTKHH 87
           A  +  L  G+  ID A +Y +     E +   +G   G +  R ++   +  W      
Sbjct: 30  AVTRAFLERGHTEIDTAFLYSDGQS--ETILGGLGLRMGSSDCRVKIATKANPWIGNSLK 87

Query: 88  PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147
           P+ V   L  +L  LQ   +DL+ +H P      D+  P              +ET +A 
Sbjct: 88  PDSVRSQLETSLKRLQCPUVDLFYLHAP------DHSAP-------------VEETLRAC 128

Query: 148 EALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEV 207
             L  +G    LGLSN+ + ++ +I ++      +L    +  L    L  HC       
Sbjct: 129 HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPT-VYQLLEGAPLRGHCPGGE--- 184

Query: 208 TAYSPLGSSDRAWRDPDEPVLLEEPV 233
                 G + R WR   +  L   PV
Sbjct: 185 ------GPAGRVWRQRSQHDLGRPPV 204


>gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]
          Length = 331

 Score = 33.5 bits (75), Expect = 0.26
 Identities = 48/199 (24%), Positives = 75/199 (37%), Gaps = 44/199 (22%)

Query: 31  AAVKYALSVGYRHIDCAAIY--GNEPEIGEALKEDVGPG--------KAVPREELFVTSK 80
           A  +  L  G+  ID A +Y  G    I   L   +G          KA+P         
Sbjct: 30  AVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP--------- 80

Query: 81  LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHY 140
           L+     P+ +   L  +L  LQ   +DL+ +H P                     ST  
Sbjct: 81  LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPD-------------------HSTPV 121

Query: 141 KETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPYLAQ--N 194
           +ET +A   L  +G    LGLSN+ + ++ +I ++      + P V Q   +    Q   
Sbjct: 122 EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVET 181

Query: 195 ELIAHCQARGLEVTAYSPL 213
           EL    +  GL   A++PL
Sbjct: 182 ELFPCLRHFGLRFYAFNPL 200


>gi|4504011 glutamate-cysteine ligase regulatory protein [Homo
           sapiens]
          Length = 274

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 15/47 (31%), Positives = 25/47 (53%)

Query: 139 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 185
           H +  W+ LE LV    + A+G S+ +  Q++ +   A V+P   QV
Sbjct: 142 HLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 188


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
            subunit [Homo sapiens]
          Length = 2270

 Score = 30.4 bits (67), Expect = 2.2
 Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 92   EPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALV 151
            +P L  +  +  L Y D Y+    + FE       +   G I  D +++++ W  L+ +V
Sbjct: 1174 DPVLTNSERNKVLRYFD-YVFTGVFTFEMVIKMIDQ---GLILQDGSYFRDLWNILDFVV 1229

Query: 152  AKGLVQALGLSN-FNSRQIDDILSVASVR 179
              G + A  L+N   + +  DI ++ S+R
Sbjct: 1230 VVGALVAFALANALGTNKGRDIKTIKSLR 1258


>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
           sapiens]
          Length = 987

 Score = 30.0 bits (66), Expect = 2.9
 Identities = 14/40 (35%), Positives = 22/40 (55%)

Query: 213 LGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRW 252
           L +S RAW+   +  +  +  + ALA +YG S    LL+W
Sbjct: 851 LSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKW 890


>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
           sapiens]
          Length = 1068

 Score = 30.0 bits (66), Expect = 2.9
 Identities = 14/40 (35%), Positives = 22/40 (55%)

Query: 213 LGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRW 252
           L +S RAW+   +  +  +  + ALA +YG S    LL+W
Sbjct: 932 LSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKW 971


>gi|24308241 zinc finger and BTB domain containing 2 [Homo sapiens]
          Length = 514

 Score = 28.9 bits (63), Expect = 6.5
 Identities = 23/78 (29%), Positives = 33/78 (42%), Gaps = 6/78 (7%)

Query: 157 QALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAH-CQARGLEVTAYSP--- 212
           Q L L  F      D + V + +P    +    +   NE++ H CQ +  +V A      
Sbjct: 424 QTLELCTFEEGSQMDNMLVQTNKPYKCNLCDKTFSTPNEVVKHSCQNQNSDVFALDEGRS 483

Query: 213 --LGSSDRAWRDPDEPVL 228
             LGS D    +PD PVL
Sbjct: 484 ILLGSGDSEVTEPDHPVL 501


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,452,638
Number of Sequences: 37866
Number of extensions: 610811
Number of successful extensions: 1383
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1314
Number of HSP's gapped (non-prelim): 28
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press