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Search of human proteins with 24429564
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 866 0.0
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 761 0.0
gi|9506959 phosphodiesterase 7B [Homo sapiens] 500 e-141
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 194 1e-49
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 194 1e-49
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 194 1e-49
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 194 1e-49
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 194 1e-49
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 194 1e-49
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 194 1e-49
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 194 2e-49
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 194 2e-49
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 194 2e-49
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 193 2e-49
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 192 4e-49
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 192 4e-49
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 173 3e-43
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 173 3e-43
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 167 2e-41
gi|4505677 phosphodiesterase 1B [Homo sapiens] 162 5e-40
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 162 7e-40
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 162 7e-40
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 162 7e-40
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 162 7e-40
gi|4826894 phosphodiesterase 1C [Homo sapiens] 159 5e-39
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 158 8e-39
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 158 8e-39
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 149 4e-36
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 149 4e-36
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 149 4e-36
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 866 bits (2237), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA 60
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
Sbjct: 1 MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA 60
Query: 61 LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS 120
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
Sbjct: 61 LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS 120
Query: 121 SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL 180
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
Sbjct: 121 SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL 180
Query: 181 HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 240
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
Sbjct: 181 HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 240
Query: 241 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS 300
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
Sbjct: 241 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS 300
Query: 301 HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC 360
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
Sbjct: 301 HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC 360
Query: 361 ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL
Sbjct: 361 ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
Query: 421 DIAG 424
DIAG
Sbjct: 421 DIAG 424
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 761 bits (1964), Expect = 0.0
Identities = 373/376 (99%), Positives = 374/376 (99%)
Query: 45 SQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS 104
S+RRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS
Sbjct: 19 SKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS 78
Query: 105 ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL 164
ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL
Sbjct: 79 ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL 138
Query: 165 TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM 224
TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM
Sbjct: 139 TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM 198
Query: 225 HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 284
HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH
Sbjct: 199 HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 258
Query: 285 HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 344
HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL
Sbjct: 259 HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 318
Query: 345 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR 404
EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR
Sbjct: 319 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR 378
Query: 405 HTESIANIQIGNYTYL 420
HTESIANIQIG TYL
Sbjct: 379 HTESIANIQIGFMTYL 394
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 500 bits (1287), Expect = e-141
Identities = 235/375 (62%), Positives = 299/375 (79%)
Query: 46 QRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSA 105
+R G I +++ DQ A + MLGD+R+R + G +ERRGS+P+IDFR+ +S + +
Sbjct: 7 ERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTK 66
Query: 106 RNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLT 165
+ ++RLLSFQRY +SR RG L++LD+DY GQA+ ML KVG W+FDIFLFDRLT
Sbjct: 67 KKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLT 126
Query: 166 NGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMH 225
NGNSLV+L HLF+ HGLI +F LDM+ L RFLVM+QEDYHSQNPYHNAVHAADVTQAMH
Sbjct: 127 NGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMH 186
Query: 226 CYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHH 285
CYLKEPKLA+ +TP DI+L L+AAA HD+DHPGVNQPFLIKTNH+LA LY+N SVLENHH
Sbjct: 187 CYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHH 246
Query: 286 WRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE 345
WRS +G+LRES L +HLP E Q +E Q+G+LILATDI+RQNE+L+ ++HL DL LE
Sbjct: 247 WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLE 306
Query: 346 DTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRH 405
D + RH +LQ+ALKCADICNPCR WE+SKQWSE+V EEF+ QG++E+K+ L +SPLC++
Sbjct: 307 DAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQ 366
Query: 406 TESIANIQIGNYTYL 420
+SI +IQIG +Y+
Sbjct: 367 KDSIPSIQIGFMSYI 381
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 194 bits (493), Expect = 1e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 368 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 427
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 428 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 487
Query: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 488 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 547
Query: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 548 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 588
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 194 bits (493), Expect = 1e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 403 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 462
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 463 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 522
Query: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 523 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 582
Query: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 583 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 623
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 194 bits (493), Expect = 1e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 429 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 488
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 489 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 548
Query: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 549 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 608
Query: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 609 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 649
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 194 bits (493), Expect = 1e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 190 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 249
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 250 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 309
Query: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 310 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 369
Query: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 370 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 410
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 194 bits (493), Expect = 1e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
Query: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
Query: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 388
Query: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 389 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 448
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 449 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 498
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 194 bits (493), Expect = 1e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
Query: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
Query: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
Query: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 572
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 194 bits (493), Expect = 1e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
Query: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
Query: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 494
Query: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 495 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 554
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 555 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 194 bits (492), Expect = 2e-49
Identities = 125/429 (29%), Positives = 221/429 (51%), Gaps = 29/429 (6%)
Query: 11 PLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYI-RMLGDV 69
P+ R PQ ++ ++ + L C + + Q ++S +S++ + R L +
Sbjct: 204 PVSRVNPQEESYQK--LAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHL 261
Query: 70 RVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRS 120
SR+G + S+ ++D Q+++E+ + R +S + L
Sbjct: 262 SEMSRSGNQVSEYISNTFLD-----KQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMH 316
Query: 121 SRFFRGTAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS 179
S T++S +N ++D+ + LE + W +IF ++ L + + +F
Sbjct: 317 SSSLNNTSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
Query: 180 LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP 239
L++ F + +++ +++ YHS YHN++HAADV Q+ H L P L T
Sbjct: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
Query: 240 WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--G 297
+IL ++ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E
Sbjct: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
Query: 298 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRH 351
+F +L + RQ + + ++LATD+S+ L+ ++ ++ G L L++ R
Sbjct: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
Query: 352 LVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIAN 411
VL+ + CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+
Sbjct: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
Query: 412 IQIGNYTYL 420
Q+G Y+
Sbjct: 614 SQVGFIDYI 622
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 194 bits (492), Expect = 2e-49
Identities = 125/429 (29%), Positives = 221/429 (51%), Gaps = 29/429 (6%)
Query: 11 PLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYI-RMLGDV 69
P+ R PQ ++ ++ + L C + + Q ++S +S++ + R L +
Sbjct: 189 PVSRVNPQEESYQK--LAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHL 246
Query: 70 RVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRS 120
SR+G + S+ ++D Q+++E+ + R +S + L
Sbjct: 247 SEMSRSGNQVSEYISNTFLD-----KQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMH 301
Query: 121 SRFFRGTAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS 179
S T++S +N ++D+ + LE + W +IF ++ L + + +F
Sbjct: 302 SSSLNNTSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 358
Query: 180 LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP 239
L++ F + +++ +++ YHS YHN++HAADV Q+ H L P L T
Sbjct: 359 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 418
Query: 240 WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--G 297
+IL ++ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E
Sbjct: 419 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 478
Query: 298 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRH 351
+F +L + RQ + + ++LATD+S+ L+ ++ ++ G L L++ R
Sbjct: 479 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 538
Query: 352 LVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIAN 411
VL+ + CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+
Sbjct: 539 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 598
Query: 412 IQIGNYTYL 420
Q+G Y+
Sbjct: 599 SQVGFIDYI 607
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 194 bits (492), Expect = 2e-49
Identities = 125/429 (29%), Positives = 221/429 (51%), Gaps = 29/429 (6%)
Query: 11 PLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYI-RMLGDV 69
P+ R PQ ++ ++ + L C + + Q ++S +S++ + R L +
Sbjct: 204 PVSRVNPQEESYQK--LAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHL 261
Query: 70 RVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRS 120
SR+G + S+ ++D Q+++E+ + R +S + L
Sbjct: 262 SEMSRSGNQVSEYISNTFLD-----KQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMH 316
Query: 121 SRFFRGTAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS 179
S T++S +N ++D+ + LE + W +IF ++ L + + +F
Sbjct: 317 SSSLNNTSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 373
Query: 180 LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP 239
L++ F + +++ +++ YHS YHN++HAADV Q+ H L P L T
Sbjct: 374 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 433
Query: 240 WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--G 297
+IL ++ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E
Sbjct: 434 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 493
Query: 298 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRH 351
+F +L + RQ + + ++LATD+S+ L+ ++ ++ G L L++ R
Sbjct: 494 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553
Query: 352 LVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIAN 411
VL+ + CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+
Sbjct: 554 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 613
Query: 412 IQIGNYTYL 420
Q+G Y+
Sbjct: 614 SQVGFIDYI 622
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 193 bits (491), Expect = 2e-49
Identities = 114/363 (31%), Positives = 191/363 (52%), Gaps = 23/363 (6%)
Query: 78 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 126
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 91 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 150
Query: 127 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 185
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 151 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 207
Query: 186 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 245
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 208 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 267
Query: 246 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 303
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 268 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 327
Query: 304 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 357
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 328 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 387
Query: 358 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNY 417
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+G
Sbjct: 388 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 447
Query: 418 TYL 420
Y+
Sbjct: 448 DYI 450
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 192 bits (489), Expect = 4e-49
Identities = 117/395 (29%), Positives = 204/395 (51%), Gaps = 15/395 (3%)
Query: 38 CPNPRQLSQRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYIDFRI---F 93
C + + Q R ++S +S++ + R L + SR+G + S+ ++D +
Sbjct: 287 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 346
Query: 94 HSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGN 153
S ++ E R + ++ ++ + SS + + +D + LE V
Sbjct: 347 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNK 403
Query: 154 WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHN 213
W +F L+ L + +F L++ F + + L +L+ +++ YH+ YHN
Sbjct: 404 WGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHN 463
Query: 214 AVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLAT 273
+HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI TN LA
Sbjct: 464 NIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELAL 523
Query: 274 LYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLS 331
+Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S+ L+
Sbjct: 524 MYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 583
Query: 332 LFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++++ EEFF
Sbjct: 584 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 643
Query: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
QGD E++ + +SP+CD+H S+ Q+G Y+
Sbjct: 644 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 678
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 192 bits (489), Expect = 4e-49
Identities = 117/395 (29%), Positives = 204/395 (51%), Gaps = 15/395 (3%)
Query: 38 CPNPRQLSQRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYIDFRI---F 93
C + + Q R ++S +S++ + R L + SR+G + S+ ++D +
Sbjct: 151 CLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEI 210
Query: 94 HSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGN 153
S ++ E R + ++ ++ + SS + + +D + LE V
Sbjct: 211 PSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNK 267
Query: 154 WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHN 213
W +F L+ L + +F L++ F + + L +L+ +++ YH+ YHN
Sbjct: 268 WGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHN 327
Query: 214 AVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLAT 273
+HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI TN LA
Sbjct: 328 NIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELAL 387
Query: 274 LYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISRQNEYLS 331
+Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S+ L+
Sbjct: 388 MYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 447
Query: 332 LFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++++ EEFF
Sbjct: 448 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 507
Query: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
QGD E++ + +SP+CD+H S+ Q+G Y+
Sbjct: 508 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 542
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 173 bits (438), Expect = 3e-43
Identities = 104/331 (31%), Positives = 173/331 (52%), Gaps = 21/331 (6%)
Query: 110 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 169
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 408 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 467
Query: 170 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 229
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 468 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 527
Query: 230 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 289
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 528 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 587
Query: 290 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 346
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 588 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 647
Query: 347 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 389
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 648 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 707
Query: 390 IEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
EK+ L V P+ DR+T SI QI Y
Sbjct: 708 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 738
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 173 bits (438), Expect = 3e-43
Identities = 104/331 (31%), Positives = 173/331 (52%), Gaps = 21/331 (6%)
Query: 110 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 169
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 454 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 513
Query: 170 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 229
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 514 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 573
Query: 230 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 289
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 574 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 633
Query: 290 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 346
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 634 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 693
Query: 347 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 389
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 694 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 753
Query: 390 IEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
EK+ L V P+ DR+T SI QI Y
Sbjct: 754 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 784
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 167 bits (422), Expect = 2e-41
Identities = 114/372 (30%), Positives = 189/372 (50%), Gaps = 26/372 (6%)
Query: 68 DVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGT 127
DV+ S G ++ + Y HS + IE ++ +RRL S Y+ F +
Sbjct: 419 DVKSISSRGSDAPSLQNRRYPSMARIHSMT-IEAPITKDGLRRL-SGNEYV----FTKNV 472
Query: 128 AVSNSLNILDDDYNGQAKCMLEKVGN---WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLI 184
S+S + N C+ + + N W+F+IF + +T+ LV L +FS G+
Sbjct: 473 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 532
Query: 185 EYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILL 244
E+ + LR + +I+ +YHS N YHN+ HAADV A +L + ++ S+ D +
Sbjct: 533 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 592
Query: 245 SLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSH 301
+LIAA HD+DHPG FL LA LY +T+VLE+HH A L + +F +
Sbjct: 593 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 652
Query: 302 LPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR-------GDLC------LEDTR 348
+ + + I ++LAT++++ E+++ F + +++ G C
Sbjct: 653 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 712
Query: 349 HRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTE 407
++ L+ +M +KCAD+ NPCR +L +W+ +++EE+F Q D EK+ L V P+ DR+T
Sbjct: 713 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 772
Query: 408 SIANIQIGNYTY 419
SI QI Y
Sbjct: 773 SIPKSQISFIDY 784
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 162 bits (410), Expect = 5e-40
Identities = 95/297 (31%), Positives = 156/297 (52%), Gaps = 13/297 (4%)
Query: 122 RFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLH 181
R FR T S + Y+ L+ + W FD+F ++ + ++L ++ F L + H
Sbjct: 137 RMFRRTYTS-----VGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
Query: 182 GLIEYFHLDMMKLRRFLVMIQEDYHS-QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 240
LI F + + L FL ++ Y +NPYHN +HAADVTQ +HC+L + + ++
Sbjct: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
Query: 241 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR--ESGL 298
++L + AAA HD +H G F I+T A +Y + SVLENHH S L++ E +
Sbjct: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
Query: 299 FSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMAL 358
F +L + ++ + ++LATD+S + + ++ L + + + L + L
Sbjct: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ-----LERIDKPKALSLLL 366
Query: 359 KCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
ADI +P + W + +W++ + EEFF QGD E + L SPLCDR + +A QIG
Sbjct: 367 HAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG 423
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 162 bits (409), Expect = 7e-40
Identities = 95/290 (32%), Positives = 158/290 (54%), Gaps = 17/290 (5%)
Query: 147 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 206
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 503 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 562
Query: 207 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 563 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 622
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 323
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 623 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 682
Query: 324 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 370
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 683 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 742
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI Y
Sbjct: 743 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 162 bits (409), Expect = 7e-40
Identities = 95/290 (32%), Positives = 158/290 (54%), Gaps = 17/290 (5%)
Query: 147 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 206
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 530 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 589
Query: 207 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 590 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 649
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 323
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 650 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 709
Query: 324 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 370
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 710 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 769
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI Y
Sbjct: 770 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 819
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 162 bits (409), Expect = 7e-40
Identities = 95/290 (32%), Positives = 158/290 (54%), Gaps = 17/290 (5%)
Query: 147 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 206
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 453 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 512
Query: 207 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 513 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 572
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 323
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 573 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 632
Query: 324 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 370
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 633 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 692
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI Y
Sbjct: 693 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 742
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 162 bits (409), Expect = 7e-40
Identities = 95/290 (32%), Positives = 158/290 (54%), Gaps = 17/290 (5%)
Query: 147 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 206
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 550 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 609
Query: 207 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 610 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 669
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 323
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 670 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 729
Query: 324 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 370
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 730 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 789
Query: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGNYTY 419
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI Y
Sbjct: 790 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 839
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 159 bits (402), Expect = 5e-39
Identities = 89/272 (32%), Positives = 147/272 (54%), Gaps = 9/272 (3%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
L+ V W+FD+F + + ++L + + L + + LI F + + L F+ ++ Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
+NPYHN +HAADVTQ +H L + +AN +T +I + +AA HD +H G F I+
Sbjct: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDI 323
T A LY + SVLENHH +A LL+ E + +L + ++ T + +++ATD+
Sbjct: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
Query: 324 SRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEE 383
S + + ++ L + + + L + L ADI +P + W+L +W+ + EE
Sbjct: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
Query: 384 FFHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
FF QGD E + L SPLCDR + +A Q+G
Sbjct: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVG 429
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 158 bits (400), Expect = 8e-39
Identities = 90/271 (33%), Positives = 147/271 (54%), Gaps = 8/271 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 324
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 325 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 384
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
Query: 385 FHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
F QGD E + L SPLCDR + +A QIG
Sbjct: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIG 419
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 158 bits (400), Expect = 8e-39
Identities = 90/271 (33%), Positives = 147/271 (54%), Gaps = 8/271 (2%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 267 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 324
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 325 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 384
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
Query: 385 FHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
F QGD E + L SPLCDR + +A QIG
Sbjct: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIG 419
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 149 bits (377), Expect = 4e-36
Identities = 91/270 (33%), Positives = 144/270 (53%), Gaps = 9/270 (3%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 46 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 101
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 102 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 160
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 325
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 161 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 220
Query: 326 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 221 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 278
Query: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
Q D EK L V+P DR + A QIG
Sbjct: 279 MQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 149 bits (377), Expect = 4e-36
Identities = 91/270 (33%), Positives = 144/270 (53%), Gaps = 9/270 (3%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 46 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 101
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 102 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 160
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 325
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 161 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 220
Query: 326 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 221 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 278
Query: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
Q D EK L V+P DR + A QIG
Sbjct: 279 MQSDREKSEGLPVAPFMDRDKVTKATAQIG 308
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 149 bits (377), Expect = 4e-36
Identities = 91/270 (33%), Positives = 144/270 (53%), Gaps = 9/270 (3%)
Query: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 227 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 282
Query: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 283 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 341
Query: 268 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 325
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 342 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 401
Query: 326 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 385
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 402 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 459
Query: 386 HQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
Q D EK L V+P DR + A QIG
Sbjct: 460 MQSDREKSEGLPVAPFMDRDKVTKATAQIG 489
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,029,641
Number of Sequences: 37866
Number of extensions: 618065
Number of successful extensions: 1957
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1747
Number of HSP's gapped (non-prelim): 78
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.