Search of human proteins with 119395738

Search of human proteins with 119395738

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119395738 insulin receptor isoform Short precursor [Homo
sapiens]
         (1370 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119395738 insulin receptor isoform Short precursor [Homo sapi...  2841   0.0  
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]  2833   0.0  
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...  1581   0.0  
gi|31657140 insulin receptor-related receptor precursor [Homo sa...  1357   0.0  
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   267   6e-71
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 259   2e-68
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   256   8e-68
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   256   8e-68
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    249   1e-65
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   244   3e-64
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   244   3e-64
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   238   3e-62
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   237   7e-62
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   237   7e-62
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   237   7e-62
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap...   236   1e-61
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     229   1e-59
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   228   2e-59
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     227   5e-59
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             227   5e-59
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     225   3e-58
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   224   4e-58
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   224   4e-58
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   224   4e-58
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur...   224   4e-58
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   221   4e-57
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   221   4e-57
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   221   4e-57
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               220   8e-57
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               220   8e-57

>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score = 2841 bits (7366), Expect = 0.0
 Identities = 1370/1370 (100%), Positives = 1370/1370 (100%)

Query: 1    MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL 60
            MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
Sbjct: 1    MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL 60

Query: 61   QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL 120
            QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
Sbjct: 61   QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL 120

Query: 121  VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE 180
            VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
Sbjct: 121  VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE 180

Query: 181  ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL 240
            ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
Sbjct: 181  ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL 240

Query: 241  GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG 300
            GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
Sbjct: 241  GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG 300

Query: 301  CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC 360
            CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
Sbjct: 301  CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC 360

Query: 361  TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL 420
            TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
Sbjct: 361  TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL 420

Query: 421  EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE 480
            EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
Sbjct: 421  EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE 480

Query: 481  RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ 540
            RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
Sbjct: 481  RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ 540

Query: 541  NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS 600
            NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
Sbjct: 541  NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS 600

Query: 601  DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE 660
            DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
Sbjct: 601  DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE 660

Query: 661  RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL 720
            RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
Sbjct: 661  RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL 720

Query: 721  KELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSP 780
            KELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSP
Sbjct: 721  KELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSP 780

Query: 781  EEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADD 840
            EEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADD
Sbjct: 781  EEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADD 840

Query: 841  IVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR 900
            IVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR
Sbjct: 841  IVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR 900

Query: 901  LRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVI 960
            LRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVI
Sbjct: 901  LRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVI 960

Query: 961  GSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQG 1020
            GSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQG
Sbjct: 961  GSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQG 1020

Query: 1021 SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV 1080
            SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV
Sbjct: 1021 SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV 1080

Query: 1081 VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA 1140
            VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA
Sbjct: 1081 VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA 1140

Query: 1141 KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV 1200
            KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV
Sbjct: 1141 KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV 1200

Query: 1201 FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMC 1260
            FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMC
Sbjct: 1201 FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMC 1260

Query: 1261 WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320
            WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS
Sbjct: 1261 WQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320

Query: 1321 SHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS 1370
            SHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
Sbjct: 1321 SHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS 1370


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score = 2833 bits (7343), Expect = 0.0
 Identities = 1370/1382 (99%), Positives = 1370/1382 (99%), Gaps = 12/1382 (0%)

Query: 1    MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL 60
            MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
Sbjct: 1    MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL 60

Query: 61   QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL 120
            QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
Sbjct: 61   QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL 120

Query: 121  VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE 180
            VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
Sbjct: 121  VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE 180

Query: 181  ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL 240
            ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
Sbjct: 181  ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL 240

Query: 241  GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG 300
            GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
Sbjct: 241  GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG 300

Query: 301  CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC 360
            CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
Sbjct: 301  CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC 360

Query: 361  TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL 420
            TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
Sbjct: 361  TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL 420

Query: 421  EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE 480
            EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
Sbjct: 421  EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE 480

Query: 481  RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ 540
            RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
Sbjct: 481  RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ 540

Query: 541  NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS 600
            NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
Sbjct: 541  NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS 600

Query: 601  DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE 660
            DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
Sbjct: 601  DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE 660

Query: 661  RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL 720
            RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
Sbjct: 661  RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL 720

Query: 721  KELEESSFRKTFEDYLHNVVFV------------PRPSRKRRSLGDVGNVTVAVPTVAAF 768
            KELEESSFRKTFEDYLHNVVFV            PRPSRKRRSLGDVGNVTVAVPTVAAF
Sbjct: 721  KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAF 780

Query: 769  PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV 828
            PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
Sbjct: 781  PNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV 840

Query: 829  SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV 888
            SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
Sbjct: 841  SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV 900

Query: 889  SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG 948
            SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
Sbjct: 901  SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG 960

Query: 949  PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSR 1008
            PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSR
Sbjct: 961  PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSR 1020

Query: 1009 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 1068
            EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
Sbjct: 1021 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 1080

Query: 1069 FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA 1128
            FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
Sbjct: 1081 FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA 1140

Query: 1129 AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV 1188
            AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
Sbjct: 1141 AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV 1200

Query: 1189 RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN 1248
            RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
Sbjct: 1201 RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN 1260

Query: 1249 CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME 1308
            CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME
Sbjct: 1261 CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEME 1320

Query: 1309 FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN 1368
            FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN
Sbjct: 1321 FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN 1380

Query: 1369 PS 1370
            PS
Sbjct: 1381 PS 1382


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score = 1581 bits (4094), Expect = 0.0
 Identities = 794/1370 (57%), Positives = 1010/1370 (73%), Gaps = 43/1370 (3%)

Query: 21   LLLGAAGHLYP--GEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS 77
            L L AA  L+P  GE+C PG+DIRN+  +L  LENC+VIEG+L ILL+ K   ED+R   
Sbjct: 17   LFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKA--EDYRSYR 74

Query: 78   FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM 137
            FPKL +IT+YLLLFRV GLESL DLFPNLTVIRG +LF+NYALVIFEM +LK++GLYNL 
Sbjct: 75   FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR 134

Query: 138  NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCP 197
            NITRG++RIEKN +LCYL+T+DWS ILD+V +NYIV NK   +ECGD+CPGT + K  C 
Sbjct: 135  NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTMEEKPMCE 193

Query: 198  ATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRN 257
             T IN ++  RCWT + CQK+CP+ C    CT    CCH ECLG+CS PD+ T CVACR+
Sbjct: 194  KTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRH 253

Query: 258  FYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS 317
            +Y  G CV  CPP  Y F+ WRCV+  FC ++    ++S  +G   +VIH+ +C+ ECPS
Sbjct: 254  YYYAGVCVPACPPNTYRFEGWRCVDRDFCANIL-SAESSDSEG---FVIHDGECMQECPS 309

Query: 318  GYTMNSS-NLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNN 376
            G+  N S ++ C PC GPCPKVC   +  KTIDSVTSAQ L+GCT+  G+L+INIR GNN
Sbjct: 310  GFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNN 369

Query: 377  LAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR 436
            +A+ELE  +GLIE ++GY+KIR S+ALVSLSF + LRLI GE    GNYSFY LDNQNL+
Sbjct: 370  IASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQ 429

Query: 437  QLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE 496
            QLWDW   NLTI  GK++F +NPKLC+SEI++MEEV+GTKGRQ + DI  + NG++ASCE
Sbjct: 430  QLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCE 489

Query: 497  NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556
            +++L F+   TS ++I++ W  Y PPD+RDL+ F ++YKEAP++NVTE+DGQDACGSNSW
Sbjct: 490  SDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSW 549

Query: 557  TVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTL-VTFSDERRTYGAKSDIIYV 615
             +VD+D P     P     PG L+ GLKPWTQYA++VK + +T  +     GAKS+I+Y+
Sbjct: 550  NMVDVDLP-----PNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYI 604

Query: 616  QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCL 675
            +T+A+ PS+PLD +S SNSSSQ+I+KW PPS PNGN+++Y+V W+RQ +D  L+  +YC 
Sbjct: 605  RTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCS 664

Query: 676  KGLKLPSRTWSP-PFESEDSQKHNQSEY-EDSAGECCSCPKTDSQILKELEESSFRKTFE 733
            K  K+P R ++    + E+  ++ ++E      G CC+CPKT+++   E EE+ +RK FE
Sbjct: 665  KD-KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFE 723

Query: 734  DYLHNVVFVPRPSRKRRSLGDVGNVTVAVP---TVAAFPNTSSTSVPTSPEEHRPF--EK 788
            ++LHN +FVPRP RKRR +  V N T++     T AA  +T + + P   E   PF   +
Sbjct: 724  NFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAA--DTYNITDPEELETEYPFFESR 781

Query: 789  VVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHE 848
            V NKE  VIS LR FT YRI++ +CN +  +  CS + +V ARTMP   ADDI GPVT E
Sbjct: 782  VDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWE 841

Query: 849  IFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGN 908
                N + L W EP+ PNGLI++YE+ Y    +++   CVSR+ +    G +L  L+PGN
Sbjct: 842  PRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRE-CVSRQEYRKYGGAKLNRLNPGN 900

Query: 909  YSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLR 968
            Y+ RI+ATSL+GNGSWT+P +FYV       + I  II  P+  + +   ++  +Y+F R
Sbjct: 901  YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR 960

Query: 969  KRQPDG-PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYE 1027
            KR       G LYAS NPEY SA+DV     YVPDEWEV+REKIT+ RELGQGSFGMVYE
Sbjct: 961  KRNNSRLGNGVLYASVNPEYFSAADV-----YVPDEWEVAREKITMSRELGQGSFGMVYE 1015

Query: 1028 GNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPT 1087
            G A+ ++K E ETRVA+KTVNE+AS+RERIEFLNEASVMK F CHHVVRLLGVVS+GQPT
Sbjct: 1016 GVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPT 1075

Query: 1088 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRD 1147
            LV+MELM  GDLKSYLRSLRPE ENNP   PP+L +MIQMA EIADGMAYLNA KFVHRD
Sbjct: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRD 1135

Query: 1148 LAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDM 1207
            LAARNCMVA DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM+PESLKDGVFTT SD+
Sbjct: 1136 LAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDV 1195

Query: 1208 WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKM 1267
            WSFGVVLWEI +LAEQPYQGLSNEQVL+FVM+GG LD+PDNCP+ + +LMRMCWQ+NPKM
Sbjct: 1196 WSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKM 1255

Query: 1268 RPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQR-- 1325
            RP+FLEI++ +K+++ P F EVSF++SEENK PE EEL++E E+ME+VPLD S+      
Sbjct: 1256 RPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLP 1315

Query: 1326 -------EEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN 1368
                    +A    G   L  + S++E  PY HMNGG+KN R L LP+S+
Sbjct: 1316 LPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSS 1365


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score = 1357 bits (3511), Expect = 0.0
 Identities = 694/1277 (54%), Positives = 876/1277 (68%), Gaps = 53/1277 (4%)

Query: 33   EVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFR 92
            EVCP +DIR+ +  L +LENCSV+EGHLQILLMF    EDFR LSFP+L  +TDYLLLFR
Sbjct: 28   EVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFR 87

Query: 93   VYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNEL 152
            VYGLESL+DLFPNL VIRG+RLF  YALVIFEM HL+++ L  L  + RG+VR+EKN EL
Sbjct: 88   VYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQEL 147

Query: 153  CYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGT--AKGKTNCPATVINGQFVERCW 210
            C+L+TIDW  +  +   N+IV NK   EEC D+CPG   A G+  C  T  +G    RCW
Sbjct: 148  CHLSTIDWGLLQPAPGANHIVGNKL-GEECADVCPGVLGAAGEP-CAKTTFSGHTDYRCW 205

Query: 211  THSHCQKVCPTICKSHG--CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETC 268
            T SHCQ+VCP     HG  CTA G CCH+ECLG CSQP+DP  CVACR+ Y  G C+  C
Sbjct: 206  TSSHCQRVCPC---PHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWAC 262

Query: 269  PPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLC 328
            PP  Y ++ WRCV    C  LH     +   G HQ       C+ +CPSG+T NSS++ C
Sbjct: 263  PPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQ-----GSCLAQCPSGFTRNSSSIFC 317

Query: 329  TPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLI 388
              C G CPK C +  G KTIDS+ +AQ+L GCT + GSLI+N+R G NL  +L+ +LGL+
Sbjct: 318  HKCEGLCPKECKV--GTKTIDSIQAAQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLV 375

Query: 389  EEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTI 448
            E I+G+LKI+ S+ALVSL FF+ L+LIRG+ +  GNY+ Y LDNQNL+QL  W    LTI
Sbjct: 376  ETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQNLQQLGSWVAAGLTI 435

Query: 449  TQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTS 508
              GK++F +NP+LCL  I+++EEV+GT+GRQ + +I  +TNGD+A+C+   L+F    T 
Sbjct: 436  PVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTE 495

Query: 509  FDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSN 568
             D+ILLRWE Y P + RDLL F+++YKE+P+QN TE  G DACG+ SW ++D++ PL   
Sbjct: 496  ADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRT 555

Query: 569  DPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTY-GAKSDIIYVQTDATNPSVPLD 627
                   PG  +  LKPWTQYA+FV+ +   ++E   + GA+S I+Y++T    P+VP D
Sbjct: 556  Q-----EPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQD 610

Query: 628  PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSP 687
             IS SNSSS ++++WKPP+  NGN+T+YLV W+R AED +L+  DYC +GL+LP+    P
Sbjct: 611  VISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNNDP 670

Query: 688  PFESEDSQKHNQSEYEDSAGECCSCPKTD-SQILKELE--ESSFRKTFEDYLHNVVFVPR 744
             F+ ED     + E      +CC C      Q+L  LE  E+SF+K FE++LHN + +P 
Sbjct: 671  RFDGEDGDPEAEME-----SDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPI 725

Query: 745  PSRKRRSLG-----DVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISG 799
               K  S+      D G    A   +    N+S   +          E  V +E  V+SG
Sbjct: 726  SPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQ---------EDKVPRERAVLSG 776

Query: 800  LRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW 859
            LRHFT YRI++ ACN       CS A +V ARTMP  +AD I G V  E    N V L W
Sbjct: 777  LRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRW 836

Query: 860  QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLA 919
             EP +PNGLI+ YE+ YRR G+E   LCVSR  +A   G  L  L PGNYS R+RATSLA
Sbjct: 837  LEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLA 896

Query: 920  GNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPL 979
            GNGSWT+   FY+    +  +    +++          +V+ ++  F  K++       L
Sbjct: 897  GNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNR----TL 952

Query: 980  YASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 1039
            YAS NPEY SASD+     YVPDEWEV RE+I+++RELGQGSFGMVYEG AR +  GE  
Sbjct: 953  YASVNPEYFSASDM-----YVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEES 1007

Query: 1040 TRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDL 1099
            T VA+KTVNE AS RE IEFL EASVMK F CHHVVRLLGVVS+GQPTLV+MELM  GDL
Sbjct: 1008 TPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDL 1067

Query: 1100 KSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF 1159
            KS+LRSLRPEAENNPG P P L EMIQMA EIADGMAYL A KFVHRDLAARNCMV+ DF
Sbjct: 1068 KSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDF 1127

Query: 1160 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITS 1219
            TVKIGDFGMTRD+YETDYYRKGGKGLLPVRWMAPESLKDG+FTT SD+WSFGVVLWEI +
Sbjct: 1128 TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVT 1187

Query: 1220 LAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
            LAEQPYQGLSNEQVLKFVMDGG L++ + CP ++ +LM  CWQ NP++RP+F  I++ ++
Sbjct: 1188 LAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247

Query: 1280 DDLHPSFPEVSFFHSEE 1296
            ++L PSF  +SF++S E
Sbjct: 1248 EELRPSFRLLSFYYSPE 1264


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  267 bits (682), Expect = 6e-71
 Identities = 138/278 (49%), Positives = 184/278 (66%), Gaps = 9/278 (3%)

Query: 1008 REKITLLRELGQGSFGMVYEGNARDIIK-GEAETRVAVKTVNESASLRERIEFLNEASVM 1066
            REK+TL   LG G+FG VYEG A DI+  G  E +VAVKT+ + ++ +E+IEFL EA +M
Sbjct: 1942 REKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM 2001

Query: 1067 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 1126
              F   ++++ LGV    +P  +++ELM  GDL +YLR  R      P     TL +++ 
Sbjct: 2002 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLVDLVD 2058

Query: 1127 MAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFT----VKIGDFGMTRDIYETDYYRKG 1181
            +  +I+ G  YL    F+HRDLAARNC+V+  D+T    VKIGDFG+ RDIY+ DYYRK 
Sbjct: 2059 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 2118

Query: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 1241
            G+GLLPVRWMAPESL DG+FTT SD+WSFG+++WEI +L  QPY   SN  VL +V  GG
Sbjct: 2119 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 2178

Query: 1242 YLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
             L+ P NCP+ + +LM  CW   P  RPTF  I + L+
Sbjct: 2179 RLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216



 Score = 34.3 bits (77), Expect = 0.84
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 2/85 (2%)

Query: 571 KSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPIS 630
           K+ + P ++++ L P+T+Y   V  +  F+ + + Y   S            + PL    
Sbjct: 146 KTVSRPSYVVKPLHPFTEYIFRVVWI--FTAQLQLYSPPSPSYRTHPHGVPETAPLIRNI 203

Query: 631 VSNSSSQIILKWKPPSDPNGNITHY 655
            S+S   + + W PP  P G I  Y
Sbjct: 204 ESSSPDTVEVSWDPPQFPGGPILGY 228


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  259 bits (661), Expect = 2e-68
 Identities = 159/418 (38%), Positives = 225/418 (53%), Gaps = 42/418 (10%)

Query: 938  VPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQ-----------PDGPLGPLYASS--- 983
            +P ++   ++   +   L     G + ++ RK Q           P+  L  L  S+   
Sbjct: 1031 LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMT 1090

Query: 984  --NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
              NP Y  A      S    D  EV R+ ITL+R LG G+FG VYEG    +    +  +
Sbjct: 1091 DYNPNYCFAGKTSSIS----DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ 1146

Query: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
            VAVKT+ E  S ++ ++FL EA ++  F   ++VR +GV  +  P  +++ELMA GDLKS
Sbjct: 1147 VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKS 1206

Query: 1102 YLRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---H 1157
            +LR  RP     P +P    + +++ +A +IA G  YL    F+HRD+AARNC++     
Sbjct: 1207 FLRETRPR----PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP 1262

Query: 1158 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI 1217
                KIGDFGM RDIY   YYRKGG  +LPV+WM PE+  +G+FT+ +D WSFGV+LWEI
Sbjct: 1263 GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEI 1322

Query: 1218 TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNL 1277
             SL   PY   SN++VL+FV  GG +D P NCP  V  +M  CWQ  P+ RP F  I+  
Sbjct: 1323 FSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER 1382

Query: 1278 LK------DDLHPSFP-EVSFFHSEENKAPESEELEMEFEDMENV-PLDRSSHCQREE 1327
            ++      D ++ + P E      EE K P      +  +D E V PL  S   +REE
Sbjct: 1383 IEYCTQDPDVINTALPIEYGPLVEEEEKVP------VRPKDPEGVPPLLVSQQAKREE 1434


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
            [Homo sapiens]
          Length = 864

 Score =  256 bits (655), Expect = 8e-68
 Identities = 126/283 (44%), Positives = 183/283 (64%), Gaps = 8/283 (2%)

Query: 1001 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFL 1060
            P   EVS   +TLLR LG G+FG VYEG    +    +  +VA+KT+ E  S ++ ++FL
Sbjct: 500  PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 559

Query: 1061 NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP- 1119
             EA ++  F   ++VR +G+  +  P L+++ELM+ GD+KS+LR  RP      G+P P 
Sbjct: 560  MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 615

Query: 1120 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HDFTVKIGDFGMTRDIYETD 1176
             +++++Q+A +IA G  YL    F+HRD+AARNC+++        KIGDFGM RDIY   
Sbjct: 616  VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675

Query: 1177 YYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKF 1236
            YYR+G + LLPV+WM PE+  +G+FT+ +D WSFGV+LWEI SL   PY G +N++VL F
Sbjct: 676  YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735

Query: 1237 VMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
            V+ GG +D P  CP  V  +M  CWQ  P++RP+F  I+  L+
Sbjct: 736  VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
            [Homo sapiens]
          Length = 803

 Score =  256 bits (655), Expect = 8e-68
 Identities = 126/283 (44%), Positives = 183/283 (64%), Gaps = 8/283 (2%)

Query: 1001 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFL 1060
            P   EVS   +TLLR LG G+FG VYEG    +    +  +VA+KT+ E  S ++ ++FL
Sbjct: 439  PGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFL 498

Query: 1061 NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPP- 1119
             EA ++  F   ++VR +G+  +  P L+++ELM+ GD+KS+LR  RP      G+P P 
Sbjct: 499  MEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL----GQPSPL 554

Query: 1120 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HDFTVKIGDFGMTRDIYETD 1176
             +++++Q+A +IA G  YL    F+HRD+AARNC+++        KIGDFGM RDIY   
Sbjct: 555  VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 614

Query: 1177 YYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKF 1236
            YYR+G + LLPV+WM PE+  +G+FT+ +D WSFGV+LWEI SL   PY G +N++VL F
Sbjct: 615  YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 674

Query: 1237 VMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
            V+ GG +D P  CP  V  +M  CWQ  P++RP+F  I+  L+
Sbjct: 675  VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 717


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  249 bits (637), Expect = 1e-65
 Identities = 122/289 (42%), Positives = 181/289 (62%), Gaps = 14/289 (4%)

Query: 1005 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS 1064
            E  R  I  +R++G+G+FG V++  A  ++  E  T VAVK + E AS   + +F  EA+
Sbjct: 569  EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628

Query: 1065 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE------------- 1111
            +M  F   ++V+LLGV + G+P  ++ E MA+GDL  +LRS+ P                
Sbjct: 629  LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688

Query: 1112 -NNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR 1170
             ++PG PP +  E + +A ++A GMAYL+ +KFVHRDLA RNC+V  +  VKI DFG++R
Sbjct: 689  VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748

Query: 1171 DIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN 1230
            +IY  DYY+      +P+RWM PES+    +TT SD+W++GVVLWEI S   QPY G+++
Sbjct: 749  NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808

Query: 1231 EQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
            E+V+ +V DG  L  P+NCP  + +LMR+CW   P  RP+F  I  +L+
Sbjct: 809  EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
            precursor [Homo sapiens]
          Length = 822

 Score =  244 bits (624), Expect = 3e-64
 Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)

Query: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
            NP+Y   ++    S   PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 513  NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 568

Query: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
            VAVKT+ + AS   R +F  EA ++      H+V+  GV  +G P ++V E M HGDL  
Sbjct: 569  VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 627

Query: 1102 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
            +LR+  P+A     G PP  L   +M+ +A +IA GM YL ++ FVHRDLA RNC+V  +
Sbjct: 628  FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 687

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
              VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SD+WS GVVLWEI 
Sbjct: 688  LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 747

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
            +  +QP+  LSN +V++ +  G  L +P  CP+ V +LM  CWQ  P MR     I  LL
Sbjct: 748  TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807

Query: 1279 KD 1280
            ++
Sbjct: 808  QN 809


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
            precursor [Homo sapiens]
          Length = 838

 Score =  244 bits (624), Expect = 3e-64
 Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)

Query: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
            NP+Y   ++    S   PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 529  NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 584

Query: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
            VAVKT+ + AS   R +F  EA ++      H+V+  GV  +G P ++V E M HGDL  
Sbjct: 585  VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 643

Query: 1102 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
            +LR+  P+A     G PP  L   +M+ +A +IA GM YL ++ FVHRDLA RNC+V  +
Sbjct: 644  FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 703

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
              VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SD+WS GVVLWEI 
Sbjct: 704  LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 763

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
            +  +QP+  LSN +V++ +  G  L +P  CP+ V +LM  CWQ  P MR     I  LL
Sbjct: 764  TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823

Query: 1279 KD 1280
            ++
Sbjct: 824  QN 825


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
            precursor [Homo sapiens]
          Length = 825

 Score =  238 bits (607), Expect = 3e-62
 Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 13/303 (4%)

Query: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
            NP+Y         + + PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 513  NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568

Query: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
            VAVK + +  +L  R +F  EA ++      H+V+  GV   G P ++V E M HGDL  
Sbjct: 569  VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627

Query: 1102 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1155
            +LR+  P+A      +    +    L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 628  FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687

Query: 1156 AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLW 1215
              +  VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SD+WSFGV+LW
Sbjct: 688  GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 747

Query: 1216 EITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1275
            EI +  +QP+  LSN +V++ +  G  L++P  CP+ V D+M  CWQ  P+ R    EI 
Sbjct: 748  EIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIY 807

Query: 1276 NLL 1278
             +L
Sbjct: 808  KIL 810


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
            [Homo sapiens]
          Length = 790

 Score =  237 bits (604), Expect = 7e-62
 Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)

Query: 984  NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
            NP+Y S + V            + R  I L  ELG+G+FG V+     +++  + +  VA
Sbjct: 487  NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 536

Query: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
            VK + E AS   R +F  EA ++      H+VR  GV ++G+P L+V E M HGDL  +L
Sbjct: 537  VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 595

Query: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
            RS  P+A+   G       P  L +++ +A+++A GM YL    FVHRDLA RNC+V   
Sbjct: 596  RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 655

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
              VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+    FTT SD+WSFGVVLWEI 
Sbjct: 656  LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 715

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
            +  +QP+  LSN + +  +  G  L++P  CP  V  +MR CWQ  P+ R +  ++
Sbjct: 716  TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
            [Homo sapiens]
          Length = 796

 Score =  237 bits (604), Expect = 7e-62
 Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)

Query: 984  NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
            NP+Y S + V            + R  I L  ELG+G+FG V+     +++  + +  VA
Sbjct: 493  NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 542

Query: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
            VK + E AS   R +F  EA ++      H+VR  GV ++G+P L+V E M HGDL  +L
Sbjct: 543  VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601

Query: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
            RS  P+A+   G       P  L +++ +A+++A GM YL    FVHRDLA RNC+V   
Sbjct: 602  RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 661

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
              VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+    FTT SD+WSFGVVLWEI 
Sbjct: 662  LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 721

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
            +  +QP+  LSN + +  +  G  L++P  CP  V  +MR CWQ  P+ R +  ++
Sbjct: 722  TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
            [Homo sapiens]
          Length = 760

 Score =  237 bits (604), Expect = 7e-62
 Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)

Query: 984  NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
            NP+Y S + V            + R  I L  ELG+G+FG V+     +++  + +  VA
Sbjct: 457  NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 506

Query: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
            VK + E AS   R +F  EA ++      H+VR  GV ++G+P L+V E M HGDL  +L
Sbjct: 507  VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 565

Query: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
            RS  P+A+   G       P  L +++ +A+++A GM YL    FVHRDLA RNC+V   
Sbjct: 566  RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 625

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
              VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+    FTT SD+WSFGVVLWEI 
Sbjct: 626  LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 685

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
            +  +QP+  LSN + +  +  G  L++P  CP  V  +MR CWQ  P+ R +  ++
Sbjct: 686  TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 741


>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sapiens]
          Length = 1015

 Score =  236 bits (601), Expect = 1e-61
 Identities = 158/513 (30%), Positives = 253/513 (49%), Gaps = 37/513 (7%)

Query: 785  PFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGP 844
            P +  +   S+++  L   T Y  E++A N    +       YVS        A   V  
Sbjct: 416  PRQSGLKNTSVMMVDLLAHTNYTFEIEAVN-GVSDLSPGARQYVSVNVTTNQAAPSPVTN 474

Query: 845  VTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGL 904
            V       N + L WQEP  PNG+I+ YE+ Y     E  +  +  K    E      GL
Sbjct: 475  VKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSK----ETTITAEGL 530

Query: 905  SPGN-YSVRIRATSLAGNGSW-------TEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLF 956
             P + Y  +IRA + AG G +       T P +   +D   +P     + +G ++   + 
Sbjct: 531  KPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVI 590

Query: 957  SVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVF--PCSVYVPDEW------EVSR 1008
             V++        K + D     ++  +    L     +  P +   P++       E+  
Sbjct: 591  GVLLSGRRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEA 650

Query: 1009 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 1068
              IT+ R +G G FG V  G  +  + G+ E  VA+KT+    + ++R +FL EAS+M  
Sbjct: 651  SCITIERVIGAGEFGEVCSGRLK--LPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQ 708

Query: 1069 FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA 1128
            F   +++ L GVV+K +P ++V E M +G L ++L+        N G+   T+ +++ M 
Sbjct: 709  FDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK-------NDGQF--TVIQLVGML 759

Query: 1129 AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR---DIYETDYYRKGGKGL 1185
              I+ GM YL+   +VHRDLAARN ++  +   K+ DFG++R   D  E  Y  +GGK  
Sbjct: 760  RGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-- 817

Query: 1186 LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQ 1245
            +P+RW APE++    FT++SD+WS+G+V+WE+ S  E+PY  ++N+ V+K V +G  L  
Sbjct: 818  IPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS 877

Query: 1246 PDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
            P +CP  +  LM  CWQ     RP F EIVN+L
Sbjct: 878  PMDCPAALYQLMLDCWQKERNSRPKFDEIVNML 910


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  229 bits (585), Expect = 1e-59
 Identities = 168/541 (31%), Positives = 264/541 (48%), Gaps = 53/541 (9%)

Query: 777  PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 836
            P  PEE    +  V    L +  L   T Y I +   +   P          +   +P  
Sbjct: 276  PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335

Query: 837  KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 894
              ++I           +   + WQEP+ P  G ++ Y ++Y+     E+ + +  R+   
Sbjct: 336  PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390

Query: 895  LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFV 953
            LE    L+G  S  N +V + A + AG+G W+ P        +  PS  A     P  +V
Sbjct: 391  LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPA--FSWPWWYV 444

Query: 954  FLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPEYLSASDVFP 995
             L +VV  +  L L       RK++             G L   Y          ++   
Sbjct: 445  LLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATL 504

Query: 996  CSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 1048
             S+ + +E +       V R K+ L + LG+G FG V EG      + ++  +VAVKT+ 
Sbjct: 505  NSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMK 561

Query: 1049 ESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKS 1101
             +   R  +E FL+EA  MK F   +V+RL+GV  +G         +V++  M HGDL S
Sbjct: 562  IAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHS 621

Query: 1102 YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 1161
            +L  L     + P   P   Q +++  A+IA GM YL+ K+F+HRDLAARNCM+  + +V
Sbjct: 622  FL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSV 677

Query: 1162 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 1221
             + DFG+++ IY  DYYR+G    +PV+W+A ESL D V+T+ SD+WSFGV +WEI +  
Sbjct: 678  CVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRG 737

Query: 1222 EQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDD 1281
            + PY G+ N ++  ++  G  L QP +C + +  LM  CW+ NP+ RP+F E+   L++ 
Sbjct: 738  QTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENT 797

Query: 1282 L 1282
            L
Sbjct: 798  L 798


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
            precursor [Homo sapiens]
          Length = 839

 Score =  228 bits (582), Expect = 2e-59
 Identities = 124/317 (39%), Positives = 180/317 (56%), Gaps = 27/317 (8%)

Query: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
            NP+Y         + + PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 513  NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568

Query: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
            VAVK + +  +L  R +F  EA ++      H+V+  GV   G P ++V E M HGDL  
Sbjct: 569  VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627

Query: 1102 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1155
            +LR+  P+A      +    +    L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 628  FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687

Query: 1156 AHDFTVKIGDFGMTRDIYETDYYRK--------------GGKGLLPVRWMAPESLKDGVF 1201
              +  VKIGDFGM+RD+Y TDYYR               GG  +LP+RWM PES+    F
Sbjct: 688  GANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKF 747

Query: 1202 TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCW 1261
            TT SD+WSFGV+LWEI +  +QP+  LSN +V++ +  G  L++P  CP+ V D+M  CW
Sbjct: 748  TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 807

Query: 1262 QFNPKMRPTFLEIVNLL 1278
            Q  P+ R    EI  +L
Sbjct: 808  QREPQQRLNIKEIYKIL 824


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  227 bits (579), Expect = 5e-59
 Identities = 166/515 (32%), Positives = 269/515 (52%), Gaps = 67/515 (13%)

Query: 823  SVAAYVSARTMPEAKADDIVGPVTHEIFENNV---VHLMWQEP--KEPNGLIVLYEVSYR 877
            +V+ ++ A T   A +   V P+   +F N     V + W +P  K+ +G +V Y +S+ 
Sbjct: 369  AVSPWILASTTEGAPS---VAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHV 425

Query: 878  RYGD-------EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYF 930
                       EE+    SR   +++       +     +VRI A +  G G +++P   
Sbjct: 426  WQSAGISKELLEEVGQNGSRARISVQ-------VHNATCTVRIAAVTRGGVGPFSDPVKI 478

Query: 931  YV-----TDYLD----VPSNIAKIIIGPLIFVFLFSVVIGSIY---LFLRKRQPDGPLGP 978
            ++      DY       P N   ++I  +   F   ++IG I    L +RKR  +   G 
Sbjct: 479  FIPAHGWVDYAPSSTPAPGNADPVLI--IFGCFCGFILIGLILYISLAIRKRVQETKFGN 536

Query: 979  LYASSNPEYL-----------SASDVFPCSVYVPDEWE-------VSREKITLLRELGQG 1020
             +   + E +            A ++   S+ V +E +       + R  + L + LG+G
Sbjct: 537  AFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEG 596

Query: 1021 SFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMKGFTCHHVVRLLG 1079
             FG V EGN +   +     +VAVKT+  +++S RE  EFL+EA+ MK F+  +V+RLLG
Sbjct: 597  EFGSVMEGNLKQ--EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLG 654

Query: 1080 VV----SKGQPT-LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1134
            V     S+G P  +V++  M +GDL +YL  L    E  P   P  LQ +++   +IA G
Sbjct: 655  VCIEMSSQGIPKPMVILPFMKYGDLHTYL--LYSRLETGPKHIP--LQTLLKFMVDIALG 710

Query: 1135 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1194
            M YL+ + F+HRDLAARNCM+  D TV + DFG+++ IY  DYYR+G    +PV+W+A E
Sbjct: 711  MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIE 770

Query: 1195 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVT 1254
            SL D V+T+ SD+W+FGV +WEI +    PY G+ N ++  +++ G  L QP++C + + 
Sbjct: 771  SLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELY 830

Query: 1255 DLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEV 1289
            ++M  CW+ +P  RPTF  ++ L  + L  S P+V
Sbjct: 831  EIMYSCWRTDPLDRPTF-SVLRLQLEKLLESLPDV 864


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  227 bits (579), Expect = 5e-59
 Identities = 164/507 (32%), Positives = 255/507 (50%), Gaps = 46/507 (9%)

Query: 797  ISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFEN-NVV 855
            IS L   T Y  ++QA N  + +       +VS        A   V P+ H++      +
Sbjct: 393  ISSLWAHTPYTFDIQAINGVSSKSPFP-PQHVSVNITTNQAAPSTV-PIMHQVSATMRSI 450

Query: 856  HLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGN-YSVRIR 914
             L W +P++PNG+I+ YE+ Y      E +  ++R         R+ GL PG  Y V++R
Sbjct: 451  TLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQ---TNTARIDGLRPGMVYVVQVR 507

Query: 915  ATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLI-------FVFLFSVVIGSIYLFL 967
            A ++AG G ++    F      D  S + + +  PLI        VF+ S+V  SI +  
Sbjct: 508  ARTVAGYGKFSGKMCFQTLTDDDYKSELREQL--PLIAGSAAAGVVFVVSLVAISI-VCS 564

Query: 968  RKRQPDGPLGPLYASSNPEYLSASDVFPCSVYV-------PDEW------EVSREKITLL 1014
            RKR        +Y+     Y +        +Y+       P+E       E+    + + 
Sbjct: 565  RKRAYSKEA--VYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIE 622

Query: 1015 RELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHV 1074
              +G G FG VY+G  +  + G+ E  VA+KT+    S ++R +FL+EAS+M  F   ++
Sbjct: 623  EVIGAGEFGEVYKGRLK--LPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNI 680

Query: 1075 VRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1134
            +RL GVV+K +P +++ E M +G L S+LR        N G+   T+ +++ M   IA G
Sbjct: 681  IRLEGVVTKSRPVMIITEFMENGALDSFLRQ-------NDGQF--TVIQLVGMLRGIAAG 731

Query: 1135 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR---DIYETDYYRKGGKGLLPVRWM 1191
            M YL    +VHRDLAARN +V  +   K+ DFG++R   D      Y     G +PVRW 
Sbjct: 732  MKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWT 791

Query: 1192 APESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPE 1251
            APE++    FT++SD+WS+G+V+WE+ S  E+PY  +SN+ V+  +     L  P +CP 
Sbjct: 792  APEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPA 851

Query: 1252 RVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
             +  LM  CWQ +   RP F EIVN L
Sbjct: 852  ALHQLMLDCWQKDRNSRPRFAEIVNTL 878


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  225 bits (573), Expect = 3e-58
 Identities = 169/550 (30%), Positives = 265/550 (48%), Gaps = 62/550 (11%)

Query: 777  PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 836
            P  PEE    +  V    L +  L   T Y I +   +   P          +   +P  
Sbjct: 276  PDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLG 335

Query: 837  KADDIVGPVTHEIFENNVVHLMWQEPKEP-NGLIVLYEVSYRRYGDEELHLCVS-RKHFA 894
              ++I           +   + WQEP+ P  G ++ Y ++Y+     E+ + +  R+   
Sbjct: 336  PPENISATRN-----GSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVT 390

Query: 895  LERGCRLRGL-SPGNYSVRIRATSLAGNGSWTEPTYFY---------VTDYLDVPSNIAK 944
            LE    L+G  S  N +V + A + AG+G W+ P             V   +  PS  A 
Sbjct: 391  LE----LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPA- 445

Query: 945  IIIGPLIFVFLFSVVIGSIYLFL-------RKRQPD-----------GPLGPLYASSNPE 986
                P  +V L +VV  +  L L       RK++             G L   Y      
Sbjct: 446  -FSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSY 504

Query: 987  YLSASDVFPCSVYVPDEWE-------VSREKITLLRELGQGSFGMVYEGNARDIIKGEAE 1039
                ++    S+ + +E +       V R K+ L + LG+G FG V EG      + ++ 
Sbjct: 505  SRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSI 561

Query: 1040 TRVAVKTVNESASLRERIE-FLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVME 1092
             +VAVKT+  +   R  +E FL+EA  MK F   +V+RL+GV  +G         +V++ 
Sbjct: 562  LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILP 621

Query: 1093 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARN 1152
             M HGDL S+L  L     + P   P   Q +++  A+IA GM YL+ K+F+HRDLAARN
Sbjct: 622  FMKHGDLHSFL--LYSRLGDQPVYLPT--QMLVKFMADIASGMEYLSTKRFIHRDLAARN 677

Query: 1153 CMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGV 1212
            CM+  + +V + DFG+++ IY  DYYR+G    +PV+W+A ESL D V+T+ SD+WSFGV
Sbjct: 678  CMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737

Query: 1213 VLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL 1272
             +WEI +  + PY G+ N ++  ++  G  L QP +C + +  LM  CW+ NP+ RP+F 
Sbjct: 738  TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFT 797

Query: 1273 EIVNLLKDDL 1282
            E+   L++ L
Sbjct: 798  ELREDLENTL 807


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  224 bits (571), Expect = 4e-58
 Identities = 120/310 (38%), Positives = 187/310 (60%), Gaps = 9/310 (2%)

Query: 975  PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDII 1034
            PL  +   S+ E  + ++V    +    +WE+SR ++TL + LG+G FG V    A  I 
Sbjct: 438  PLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 497

Query: 1035 KGEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVM 1091
            K  A     VAVK + + A+ ++  + ++E  +MK    H +++ LLG  ++G P  V++
Sbjct: 498  KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 557

Query: 1092 ELMAHGDLKSYLRSLRPEAEN---NPGRPPP---TLQEMIQMAAEIADGMAYLNAKKFVH 1145
            E  A G+L+ +LR+ RP   +   +  +PP    T ++++  A ++A GM YL ++K +H
Sbjct: 558  EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 617

Query: 1146 RDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS 1205
            RDLAARN +V  D  +KI DFG+ RD++  DYY+K   G LPV+WMAPE+L D V+T  S
Sbjct: 618  RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 677

Query: 1206 DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNP 1265
            D+WSFGV+LWEI +L   PY G+  E++ K + +G  +D+P NC   +  +MR CW   P
Sbjct: 678  DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 737

Query: 1266 KMRPTFLEIV 1275
              RPTF ++V
Sbjct: 738  SQRPTFKQLV 747


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  224 bits (571), Expect = 4e-58
 Identities = 120/310 (38%), Positives = 187/310 (60%), Gaps = 9/310 (2%)

Query: 975  PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDII 1034
            PL  +   S+ E  + ++V    +    +WE+SR ++TL + LG+G FG V    A  I 
Sbjct: 324  PLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383

Query: 1035 KGEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVM 1091
            K  A     VAVK + + A+ ++  + ++E  +MK    H +++ LLG  ++G P  V++
Sbjct: 384  KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443

Query: 1092 ELMAHGDLKSYLRSLRPEAEN---NPGRPPP---TLQEMIQMAAEIADGMAYLNAKKFVH 1145
            E  A G+L+ +LR+ RP   +   +  +PP    T ++++  A ++A GM YL ++K +H
Sbjct: 444  EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503

Query: 1146 RDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS 1205
            RDLAARN +V  D  +KI DFG+ RD++  DYY+K   G LPV+WMAPE+L D V+T  S
Sbjct: 504  RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563

Query: 1206 DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNP 1265
            D+WSFGV+LWEI +L   PY G+  E++ K + +G  +D+P NC   +  +MR CW   P
Sbjct: 564  DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623

Query: 1266 KMRPTFLEIV 1275
              RPTF ++V
Sbjct: 624  SQRPTFKQLV 633


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  224 bits (571), Expect = 4e-58
 Identities = 120/310 (38%), Positives = 187/310 (60%), Gaps = 9/310 (2%)

Query: 975  PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDII 1034
            PL  +   S+ E  + ++V    +    +WE+SR ++TL + LG+G FG V    A  I 
Sbjct: 436  PLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 495

Query: 1035 KGEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVM 1091
            K  A     VAVK + + A+ ++  + ++E  +MK    H +++ LLG  ++G P  V++
Sbjct: 496  KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 555

Query: 1092 ELMAHGDLKSYLRSLRPEAEN---NPGRPPP---TLQEMIQMAAEIADGMAYLNAKKFVH 1145
            E  A G+L+ +LR+ RP   +   +  +PP    T ++++  A ++A GM YL ++K +H
Sbjct: 556  EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 615

Query: 1146 RDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS 1205
            RDLAARN +V  D  +KI DFG+ RD++  DYY+K   G LPV+WMAPE+L D V+T  S
Sbjct: 616  RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 675

Query: 1206 DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNP 1265
            D+WSFGV+LWEI +L   PY G+  E++ K + +G  +D+P NC   +  +MR CW   P
Sbjct: 676  DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 735

Query: 1266 KMRPTFLEIV 1275
              RPTF ++V
Sbjct: 736  SQRPTFKQLV 745


>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
            [Homo sapiens]
          Length = 734

 Score =  224 bits (571), Expect = 4e-58
 Identities = 106/241 (43%), Positives = 159/241 (65%), Gaps = 8/241 (3%)

Query: 1043 AVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY 1102
            + +T+ E  S ++ ++FL EA ++  F   ++VR +G+  +  P L+++ELM+ GD+KS+
Sbjct: 412  SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471

Query: 1103 LRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HD 1158
            LR  RP      G+P P  +++++Q+A +IA G  YL    F+HRD+AARNC+++     
Sbjct: 472  LRHSRPHL----GQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS 527

Query: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
               KIGDFGM RDIY   YYR+G + LLPV+WM PE+  +G+FT+ +D WSFGV+LWEI 
Sbjct: 528  RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIF 587

Query: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
            SL   PY G +N++VL FV+ GG +D P  CP  V  +M  CWQ  P++RP+F  I+  L
Sbjct: 588  SLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647

Query: 1279 K 1279
            +
Sbjct: 648  Q 648


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
            [Homo sapiens]
          Length = 762

 Score =  221 bits (563), Expect = 4e-57
 Identities = 112/284 (39%), Positives = 173/284 (60%), Gaps = 9/284 (3%)

Query: 1004 WEVSREKITLLRELGQGSFGMVYEGNA--RDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
            WE  R+++ L + LG+G FG V    A   D  + +  + VAVK + ++AS ++  + ++
Sbjct: 420  WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 479

Query: 1062 EASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN-NPGRP-- 1117
            E  VMK    H +++ LLGV ++  P  V++E  A G+L+ +LR+ RP   + +P  P  
Sbjct: 480  EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 539

Query: 1118 ---PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE 1174
               P +   ++  A ++A GM YL ++K +HRDLAARN +V  D  +KI DFG+ R ++ 
Sbjct: 540  SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 599

Query: 1175 TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL 1234
             DYY+K   G LPV+WMAPE+L D V+T  SD+WSFG++LWEI +L   PY G+  E++ 
Sbjct: 600  IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 659

Query: 1235 KFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
              + +G  +D+P +CP  +  LMR CW   P  RPTF ++V  L
Sbjct: 660  SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 703


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  221 bits (563), Expect = 4e-57
 Identities = 112/284 (39%), Positives = 173/284 (60%), Gaps = 9/284 (3%)

Query: 1004 WEVSREKITLLRELGQGSFGMVYEGNA--RDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
            WE  R+++ L + LG+G FG V    A   D  + +  + VAVK + ++AS ++  + ++
Sbjct: 460  WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 519

Query: 1062 EASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN-NPGRP-- 1117
            E  VMK    H +++ LLGV ++  P  V++E  A G+L+ +LR+ RP   + +P  P  
Sbjct: 520  EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 579

Query: 1118 ---PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE 1174
               P +   ++  A ++A GM YL ++K +HRDLAARN +V  D  +KI DFG+ R ++ 
Sbjct: 580  SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 639

Query: 1175 TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL 1234
             DYY+K   G LPV+WMAPE+L D V+T  SD+WSFG++LWEI +L   PY G+  E++ 
Sbjct: 640  IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 699

Query: 1235 KFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
              + +G  +D+P +CP  +  LMR CW   P  RPTF ++V  L
Sbjct: 700  SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  221 bits (563), Expect = 4e-57
 Identities = 112/284 (39%), Positives = 173/284 (60%), Gaps = 9/284 (3%)

Query: 1004 WEVSREKITLLRELGQGSFGMVYEGNA--RDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
            WE  R+++ L + LG+G FG V    A   D  + +  + VAVK + ++AS ++  + ++
Sbjct: 460  WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 519

Query: 1062 EASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN-NPGRP-- 1117
            E  VMK    H +++ LLGV ++  P  V++E  A G+L+ +LR+ RP   + +P  P  
Sbjct: 520  EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 579

Query: 1118 ---PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE 1174
               P +   ++  A ++A GM YL ++K +HRDLAARN +V  D  +KI DFG+ R ++ 
Sbjct: 580  SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 639

Query: 1175 TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL 1234
             DYY+K   G LPV+WMAPE+L D V+T  SD+WSFG++LWEI +L   PY G+  E++ 
Sbjct: 640  IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 699

Query: 1235 KFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
              + +G  +D+P +CP  +  LMR CW   P  RPTF ++V  L
Sbjct: 700  SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  220 bits (560), Expect = 8e-57
 Identities = 126/341 (36%), Positives = 183/341 (53%), Gaps = 28/341 (8%)

Query: 1003 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 1062
            +WE  R+ + L + LG+G FG V +  A  +      T VAVK + E+AS  E  + L+E
Sbjct: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775

Query: 1063 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------------- 1108
             +V+K     HV++L G  S+  P L+++E   +G L+ +LR  R               
Sbjct: 776  FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835

Query: 1109 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 1168
             + ++P     T+ ++I  A +I+ GM YL   K VHRDLAARN +VA    +KI DFG+
Sbjct: 836  SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895

Query: 1169 TRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL 1228
            +RD+YE D Y K  +G +PV+WMA ESL D ++TT SD+WSFGV+LWEI +L   PY G+
Sbjct: 896  SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955

Query: 1229 SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD-------- 1280
              E++   +  G  +++PDNC E +  LM  CW+  P  RP F +I   L+         
Sbjct: 956  PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY 1015

Query: 1281 -DLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320
             DL  S P  S  + +        E E    D  N PL R+
Sbjct: 1016 LDLAASTPSDSLIYDD-----GLSEEETPLVDCNNAPLPRA 1051


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  220 bits (560), Expect = 8e-57
 Identities = 126/341 (36%), Positives = 183/341 (53%), Gaps = 28/341 (8%)

Query: 1003 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 1062
            +WE  R+ + L + LG+G FG V +  A  +      T VAVK + E+AS  E  + L+E
Sbjct: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775

Query: 1063 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------------- 1108
             +V+K     HV++L G  S+  P L+++E   +G L+ +LR  R               
Sbjct: 776  FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835

Query: 1109 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 1168
             + ++P     T+ ++I  A +I+ GM YL   K VHRDLAARN +VA    +KI DFG+
Sbjct: 836  SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895

Query: 1169 TRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL 1228
            +RD+YE D Y K  +G +PV+WMA ESL D ++TT SD+WSFGV+LWEI +L   PY G+
Sbjct: 896  SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955

Query: 1229 SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD-------- 1280
              E++   +  G  +++PDNC E +  LM  CW+  P  RP F +I   L+         
Sbjct: 956  PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY 1015

Query: 1281 -DLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320
             DL  S P  S  + +        E E    D  N PL R+
Sbjct: 1016 LDLAASTPSDSLIYDD-----GLSEEETPLVDCNNAPLPRA 1051


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,694,616
Number of Sequences: 37866
Number of extensions: 2820916
Number of successful extensions: 9928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 413
Number of HSP's that attempted gapping in prelim test: 6848
Number of HSP's gapped (non-prelim): 2091
length of query: 1370
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1255
effective length of database: 13,892,928
effective search space: 17435624640
effective search space used: 17435624640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.