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Search of human proteins with 119393876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119393876 NLR family, apoptosis inhibitory protein isoform 2
[Homo sapiens]
(1241 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 ... 2482 0.0
gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 ... 2356 0.0
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 209 1e-53
gi|11545910 livin inhibitor of apoptosis isoform beta [Homo sapi... 85 5e-16
gi|21536421 livin inhibitor of apoptosis isoform alpha [Homo sap... 85 5e-16
gi|32528299 baculoviral IAP repeat-containing protein 4 [Homo sa... 77 1e-13
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap... 75 5e-13
gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo sa... 73 2e-12
gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo sap... 73 2e-12
gi|44680139 baculoviral IAP repeat-containing 8 [Homo sapiens] 63 2e-09
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 61 6e-09
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 58 6e-08
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 58 6e-08
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 58 6e-08
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 58 6e-08
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 58 6e-08
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 55 4e-07
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 54 1e-06
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 52 3e-06
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 52 3e-06
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 52 3e-06
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 52 3e-06
gi|59859878 baculoviral IAP repeat-containing protein 5 isoform ... 51 8e-06
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 50 2e-05
gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens] 49 3e-05
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 46 2e-04
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 46 2e-04
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 46 2e-04
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 46 2e-04
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 46 2e-04
>gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 [Homo
sapiens]
Length = 1241
Score = 2482 bits (6433), Expect = 0.0
Identities = 1241/1241 (100%), Positives = 1241/1241 (100%)
Query: 1 MPLHIGDFVWDSKVHSLQSSLNIFSLLPTKGRTEHLFFSHILSFHWPAFSSIRLELWINL 60
MPLHIGDFVWDSKVHSLQSSLNIFSLLPTKGRTEHLFFSHILSFHWPAFSSIRLELWINL
Sbjct: 1 MPLHIGDFVWDSKVHSLQSSLNIFSLLPTKGRTEHLFFSHILSFHWPAFSSIRLELWINL 60
Query: 61 RCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 120
RCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL
Sbjct: 61 RCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 120
Query: 121 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 180
DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC
Sbjct: 121 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 180
Query: 181 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 240
PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN
Sbjct: 181 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 240
Query: 241 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 300
LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL
Sbjct: 241 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 300
Query: 301 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 360
NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ
Sbjct: 301 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 360
Query: 361 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 420
LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR
Sbjct: 361 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 420
Query: 421 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 480
TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP
Sbjct: 421 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 480
Query: 481 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 540
LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS
Sbjct: 481 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 540
Query: 541 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 600
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
Sbjct: 541 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 600
Query: 601 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 660
DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE
Sbjct: 601 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 660
Query: 661 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 720
NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP
Sbjct: 661 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 720
Query: 721 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 780
FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ
Sbjct: 721 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 780
Query: 781 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 840
VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL
Sbjct: 781 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 840
Query: 841 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 900
EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK
Sbjct: 841 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 900
Query: 901 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 960
LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP
Sbjct: 901 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 960
Query: 961 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1020
EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK
Sbjct: 961 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1020
Query: 1021 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1080
LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL
Sbjct: 1021 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1080
Query: 1081 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1140
PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN
Sbjct: 1081 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1140
Query: 1141 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1200
HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML
Sbjct: 1141 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1200
Query: 1201 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1241
SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK
Sbjct: 1201 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1241
>gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 [Homo
sapiens]
Length = 1403
Score = 2356 bits (6106), Expect = 0.0
Identities = 1180/1181 (99%), Positives = 1181/1181 (100%)
Query: 61 RCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 120
+CEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL
Sbjct: 223 KCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRL 282
Query: 121 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 180
DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC
Sbjct: 283 DSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC 342
Query: 181 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 240
PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN
Sbjct: 343 PFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKN 402
Query: 241 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 300
LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL
Sbjct: 403 LNEQLRAAYTSASFRHMSLLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNL 462
Query: 301 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 360
NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ
Sbjct: 463 NSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQ 522
Query: 361 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 420
LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR
Sbjct: 523 LLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVR 582
Query: 421 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 480
TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP
Sbjct: 583 TNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTP 642
Query: 481 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 540
LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS
Sbjct: 643 LFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFS 702
Query: 541 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 600
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
Sbjct: 703 CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS 762
Query: 601 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 660
DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE
Sbjct: 763 DRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLE 822
Query: 661 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 720
NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP
Sbjct: 823 NISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSP 882
Query: 721 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 780
FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ
Sbjct: 883 FVLQFLQGRTLTLGALNLQYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQ 942
Query: 781 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 840
VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL
Sbjct: 943 VPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCL 1002
Query: 841 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 900
EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK
Sbjct: 1003 EVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISK 1062
Query: 901 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 960
LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP
Sbjct: 1063 LELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIP 1122
Query: 961 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1020
EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK
Sbjct: 1123 EEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKK 1182
Query: 1021 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1080
LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL
Sbjct: 1183 LTEIKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELIL 1242
Query: 1081 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1140
PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN
Sbjct: 1243 PTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSIN 1302
Query: 1141 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1200
HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML
Sbjct: 1303 HKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNML 1362
Query: 1201 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1241
SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK
Sbjct: 1363 SWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK 1403
Score = 96.3 bits (238), Expect = 2e-19
Identities = 43/84 (51%), Positives = 57/84 (67%), Gaps = 1/84 (1%)
Query: 116 EELRLDSFKDWP-RESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHT 174
EE RL SF++WP + L++AG +TG +D VQCFSCGGCL W+EGDDP +H
Sbjct: 159 EEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHA 218
Query: 175 RCFPNCPFLQNMKSSAEVTPDLQS 198
+ FP C FL++ KSS E+T +QS
Sbjct: 219 KWFPKCEFLRSKKSSEEITQYIQS 242
Score = 45.1 bits (105), Expect = 4e-04
Identities = 25/70 (35%), Positives = 36/70 (51%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
E RL +F + S+ +A AG ++TG+K +QCF C L P++DH R
Sbjct: 60 EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKR 119
Query: 176 CFPNCPFLQN 185
P+C FL N
Sbjct: 120 FHPDCGFLLN 129
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 209 bits (532), Expect = 1e-53
Identities = 236/951 (24%), Positives = 416/951 (43%), Gaps = 112/951 (11%)
Query: 289 EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR 348
E L L + L S +EGE+G GK+ LL++IA LW SG C L +F+ VF+L LS R
Sbjct: 150 EQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLS--R 207
Query: 349 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEIC--SIPQVIGKLIQ 406
GL +CDQLL+ G++ + ++ +L+ +VLFLLD Y E + P+ I LI+
Sbjct: 208 AQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPE-IEALIK 266
Query: 407 KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVY 466
+NH + +++ T R IR++ E+ + ++R++ + ++
Sbjct: 267 ENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAE--GLLLQ 324
Query: 467 FGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNK------ATA 520
K++ L+ + KTPLFV CA S +F ++ + L +NK A +
Sbjct: 325 IQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAAS 384
Query: 521 EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRF 580
+ +++ + CG+LAL+G FS F+F D++ V+ED LT L+ K+TAQR +P Y+F
Sbjct: 385 DFIRS-LDHCGDLALEGVFSHKFDFELQDVSS--VNEDVLLTTGLLCKYTAQRFKPKYKF 441
Query: 581 LSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYV--SSLPS 638
+FQE+ AG RL LL S E G +L+++ S S Y++ L Y SS+ +
Sbjct: 442 FHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEA 501
Query: 639 TKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVS 698
T+A ++ HL V L +S L Q + L+ + Q ++
Sbjct: 502 TRA---VMKHLA-AVYQHGCLLGLSIAKRPLWRQ-------ESLQSVKNTTEQEILKAIN 550
Query: 699 EHLLVLALKTAYQSNT-VAACSPFVLQFLQGRTLTLGALNL-QYFFDHPESLSLLRSIHF 756
+ V YQ +T +A S F QG++L + + N+ Y FD
Sbjct: 551 INSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFD------------- 597
Query: 757 PIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYM-DM 815
F L C S + I D+ M WE+ ED +M +
Sbjct: 598 -----------FFEHLPNC--ASALDFIKLDFYGG--AMASWEK---AAEDTGGIHMEEA 639
Query: 816 QRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHS 875
P + + ++++ LEV + D + + + L +FS++ + L +
Sbjct: 640 PETYIPSRAVSLFFNWKQEFR--TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRC 697
Query: 876 RGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPN 935
G S+ L K ++ + L+ ++ + ++ +L++L + Q+Q P
Sbjct: 698 AGVAGSLSLVLSTCK-NIYSLMVEASPLTIEDERHITSVTNLKTLSIH---DLQNQRLPG 753
Query: 936 --LDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSP 993
D LK L+ + NI + E D KL + ++N
Sbjct: 754 GLTDSLGNLKNLTKLIMDNIKM----------------------NEEDAIKLAEGLKNLK 791
Query: 994 NLHVFHLKCNFFSDFGSLMTMLVSCKK-----LTEIKFSDSFF--QAVPFVA-SLPNFIS 1045
+ +FHL SD G M +V L EI+ AV +A +L N +
Sbjct: 792 KMCLFHL--THLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVK 849
Query: 1046 LKILNLEGQQFPDEETSEKFAYILGSLSNLEE---LILPTGDGIYRVAKLIIQQCQQLHC 1102
L IL+L + + +++ +E ++ ++ LE+ L+LP G + +++ +++
Sbjct: 850 LSILDL-SENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQ 908
Query: 1103 LRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNL 1161
L L L D + + + + L L+ N +++ +G+ F +N+ L
Sbjct: 909 LVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQL 967
Query: 1162 QELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALL 1212
D S T+ V+ LSQ + +L L ++ W D DD++++
Sbjct: 968 VFFDFS---TKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVI 1015
Score = 40.0 bits (92), Expect = 0.014
Identities = 54/248 (21%), Positives = 105/248 (42%), Gaps = 42/248 (16%)
Query: 1009 GSLMTMLVSCKKLTE--IKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFA 1066
GSL +L +CK + ++ S + + S+ N +L I +L+ Q+ P T
Sbjct: 702 GSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDS--- 758
Query: 1067 YILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVE----IAK 1122
LG+L NL +LI+ D I + I+ + L L+ + F + + E I K
Sbjct: 759 --LGNLKNLTKLIM---DNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVK 813
Query: 1123 VAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQAT--- 1179
++S LE ++L ++ ++ + Q L N+ L LD+S ++ E +A
Sbjct: 814 -SLSSEPCDLEEIQL-VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHEL 871
Query: 1180 -----------------------TVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK 1216
++ SL + + +P+L++L + +W L +I +L
Sbjct: 872 IDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFF 931
Query: 1217 ERHPQSKY 1224
++P +
Sbjct: 932 GKNPLKNF 939
>gi|11545910 livin inhibitor of apoptosis isoform beta [Homo
sapiens]
Length = 280
Score = 84.7 bits (208), Expect = 5e-16
Identities = 46/110 (41%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
EELRL SF DWP + V LA AG F+TG +D V+CF C G L+ W+ GDDP +H +
Sbjct: 87 EELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAK 146
Query: 176 CFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVP 225
FP+C FL K V ++ +L + E ED+ V P VP
Sbjct: 147 WFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEP--EDAAPVAPSVP 194
Score = 30.8 bits (68), Expect = 8.4
Identities = 27/89 (30%), Positives = 33/89 (37%), Gaps = 5/89 (5%)
Query: 146 GIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC---PFLQNMKSSAEVTPDLQSRGEL 202
G KD +C G W GD P + RC P P L A D Q G+L
Sbjct: 2 GPKDSAKCLHRGPQPSHWAAGDGPTQE--RCGPRSLGSPVLGLDTCRAWDHVDGQILGQL 59
Query: 203 CELLETTSESNLEDSIAVGPIVPEMAQGE 231
L E E +++ GP P M E
Sbjct: 60 RPLTEEEEEEGAGATLSRGPAFPGMGSEE 88
>gi|21536421 livin inhibitor of apoptosis isoform alpha [Homo
sapiens]
Length = 298
Score = 84.7 bits (208), Expect = 5e-16
Identities = 46/110 (41%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
EELRL SF DWP + V LA AG F+TG +D V+CF C G L+ W+ GDDP +H +
Sbjct: 87 EELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAK 146
Query: 176 CFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVP 225
FP+C FL K V ++ +L + E ED+ V P VP
Sbjct: 147 WFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEP--EDAAPVAPSVP 194
Score = 30.8 bits (68), Expect = 8.4
Identities = 27/89 (30%), Positives = 33/89 (37%), Gaps = 5/89 (5%)
Query: 146 GIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNC---PFLQNMKSSAEVTPDLQSRGEL 202
G KD +C G W GD P + RC P P L A D Q G+L
Sbjct: 2 GPKDSAKCLHRGPQPSHWAAGDGPTQE--RCGPRSLGSPVLGLDTCRAWDHVDGQILGQL 59
Query: 203 CELLETTSESNLEDSIAVGPIVPEMAQGE 231
L E E +++ GP P M E
Sbjct: 60 RPLTEEEEEEGAGATLSRGPAFPGMGSEE 88
>gi|32528299 baculoviral IAP repeat-containing protein 4 [Homo
sapiens]
Length = 497
Score = 76.6 bits (187), Expect = 1e-13
Identities = 47/120 (39%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
EE RL SF++WP + + LA AGL+YTGI D VQCF CGG L+ W+ D +H R
Sbjct: 163 EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 222
Query: 176 CFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWF 235
FPNC F+ + D S S+ N +S + P P MA EA+ F
Sbjct: 223 HFPNCFFVLGRNLNIRSESDAVS-----------SDRNFPNSTNL-PRNPSMADYEARIF 270
Score = 67.4 bits (163), Expect = 8e-11
Identities = 32/86 (37%), Positives = 44/86 (51%)
Query: 113 FAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDD 172
F E RL +F ++P S V + LA+AG YTG D V+CFSC +++WQ GD +
Sbjct: 23 FVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGR 82
Query: 173 HTRCFPNCPFLQNMKSSAEVTPDLQS 198
H + PNC F+ T S
Sbjct: 83 HRKVSPNCRFINGFYLENSATQSTNS 108
Score = 61.6 bits (148), Expect = 4e-09
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 11/168 (6%)
Query: 99 RELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGG 158
R P ++ + A E R+ +F W +V LA+AG + G D V+CF CGG
Sbjct: 248 RNFPNSTNLPRNPSMADYEARIFTFGTWIY--SVNKEQLARAGFYALGEGDKVKCFHCGG 305
Query: 159 CLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES------ 212
L W+ +DP + H + +P C +L K E ++ L E L T+E
Sbjct: 306 GLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQ-EYINNIHLTHSLEECLVRTTEKTPSLTR 364
Query: 213 NLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLL 260
++D+I P+V E + F++ K + E+ + + ++++ + +L
Sbjct: 365 RIDDTIFQNPMVQEAIRMGFS-FKDIKKIMEE-KIQISGSNYKSLEVL 410
>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
sapiens]
Length = 618
Score = 74.7 bits (182), Expect = 5e-13
Identities = 30/78 (38%), Positives = 50/78 (64%)
Query: 113 FAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDD 172
F+ E R+ ++ +P V +LA+AG +YTG+ D V+CF CG L+ W+ GD P+
Sbjct: 43 FSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQK 102
Query: 173 HTRCFPNCPFLQNMKSSA 190
H + +P+C F+QN+ S++
Sbjct: 103 HKQLYPSCSFIQNLVSAS 120
Score = 74.7 bits (182), Expect = 5e-13
Identities = 43/107 (40%), Positives = 58/107 (54%), Gaps = 3/107 (2%)
Query: 119 RLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFP 178
R+ +F WP V LA AG +Y G D V+CF C G L W+ GDDP +H + FP
Sbjct: 272 RMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFP 331
Query: 179 NCPFLQNMKSSAEVTPDLQSR-GELCELLETTSESNLEDSIAVGPIV 224
C FL MK E ++Q R L E L +TS++ E++ A PI+
Sbjct: 332 RCEFLIRMKGQ-EFVDEIQGRYPHLLEQLLSTSDTTGEEN-ADPPII 376
Score = 71.2 bits (173), Expect = 6e-12
Identities = 32/70 (45%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
EE R ++ WP + + + LA+AG +Y G D V CF+CGG L W+ DD + +H R
Sbjct: 184 EEARFLTYHMWPL-TFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRR 242
Query: 176 CFPNCPFLQN 185
FPNCPFL+N
Sbjct: 243 HFPNCPFLEN 252
>gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 72.8 bits (177), Expect = 2e-12
Identities = 40/104 (38%), Positives = 51/104 (49%), Gaps = 4/104 (3%)
Query: 119 RLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFP 178
R +F +WP V LA AG +Y G D V+CF C G L W+ GDDP H + FP
Sbjct: 258 RFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFP 317
Query: 179 NCPFLQNMKSSAEVTPDLQSRGELCELLETTSES----NLEDSI 218
C +L +K + S L E L +TS+S N E SI
Sbjct: 318 RCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSI 361
Score = 71.2 bits (173), Expect = 6e-12
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
E R+ ++ +P V +LA+AG +YTG+ D V+CF CG L+ W+ GD P + H +
Sbjct: 29 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88
Query: 176 CFPNCPFLQNMKS 188
+P+C F+Q++ S
Sbjct: 89 LYPSCRFVQSLNS 101
Score = 68.9 bits (167), Expect = 3e-11
Identities = 31/70 (44%), Positives = 43/70 (61%), Gaps = 1/70 (1%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
E RL +F+ WP + + LAKAG +Y G D V CF+CGG L W+ D+ + +H R
Sbjct: 169 ENARLLTFQTWPL-TFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLR 227
Query: 176 CFPNCPFLQN 185
FP CPF++N
Sbjct: 228 HFPKCPFIEN 237
>gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 72.8 bits (177), Expect = 2e-12
Identities = 40/104 (38%), Positives = 51/104 (49%), Gaps = 4/104 (3%)
Query: 119 RLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFP 178
R +F +WP V LA AG +Y G D V+CF C G L W+ GDDP H + FP
Sbjct: 258 RFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFP 317
Query: 179 NCPFLQNMKSSAEVTPDLQSRGELCELLETTSES----NLEDSI 218
C +L +K + S L E L +TS+S N E SI
Sbjct: 318 RCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSI 361
Score = 71.2 bits (173), Expect = 6e-12
Identities = 28/73 (38%), Positives = 46/73 (63%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
E R+ ++ +P V +LA+AG +YTG+ D V+CF CG L+ W+ GD P + H +
Sbjct: 29 ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88
Query: 176 CFPNCPFLQNMKS 188
+P+C F+Q++ S
Sbjct: 89 LYPSCRFVQSLNS 101
Score = 68.9 bits (167), Expect = 3e-11
Identities = 31/70 (44%), Positives = 43/70 (61%), Gaps = 1/70 (1%)
Query: 116 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTR 175
E RL +F+ WP + + LAKAG +Y G D V CF+CGG L W+ D+ + +H R
Sbjct: 169 ENARLLTFQTWPL-TFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLR 227
Query: 176 CFPNCPFLQN 185
FP CPF++N
Sbjct: 228 HFPKCPFIEN 237
>gi|44680139 baculoviral IAP repeat-containing 8 [Homo sapiens]
Length = 236
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/149 (27%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 117 ELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRC 176
E RL +F W +V LA+AG + G +D VQCF CGG L W+ +DP + H +
Sbjct: 5 EARLITFGTWMY--SVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKW 62
Query: 177 FPNCPFLQNMKSSAEVTPDLQSRGELCELLETTSES-----NLEDSIAVGPIVPEMAQGE 231
+P C +L K + +R L++TT ++ + D+I P++ E +
Sbjct: 63 YPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMG 122
Query: 232 AQWFQEAKNLNEQLRAAYTSASFRHMSLL 260
F++ K + E+ R + ++++ + +L
Sbjct: 123 FD-FKDVKKIMEE-RIQTSGSNYKTLEVL 149
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 61.2 bits (147), Expect = 6e-09
Identities = 82/369 (22%), Positives = 151/369 (40%), Gaps = 41/369 (11%)
Query: 286 PVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLS 345
P P VLP G + + + G AG GKT L +K+ WA L+++F+ FYLS
Sbjct: 194 PFSNPRVLP---GPFSYTVVLYGPAGLGKTTLAQKLMLDWAED--NLIHKFKYAFYLSC- 247
Query: 346 STRPDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------I 394
R L +L+ ++ + + +I+ Q + ++LF++D + E I
Sbjct: 248 --RELSRLGPCSFAELVFRDWPELQDDIPHILAQAR-KILFVIDGFDELGAAPGALIEDI 304
Query: 395 CS-------IPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNT 445
C +P ++G L+ + L + LL+ R RD+R E + ++ F +
Sbjct: 305 CGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDR 364
Query: 446 VCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVF 505
+ F +R F + N +L ++ P +C + + D V
Sbjct: 365 RAYFLRHFGDEDQAMRAFEL-MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTC 422
Query: 506 KS----YMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDL 561
+ ++ L R A+ L+ + + LA +G ++ + +DL GV E DL
Sbjct: 423 LTRTGLFLRFLCSRFPQGAQ-LRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE-SDL 480
Query: 562 TMCLMSKFTAQR--LRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSP 619
+ L Q + Y F+ +FQ+FL L L+ + +E +D + + +
Sbjct: 481 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTA--LFYTLEKEEEEDRDGHTWDIGDVQKL 538
Query: 620 MMTVSAYNN 628
+ V N
Sbjct: 539 LSGVERLRN 547
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 303 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 362
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 404
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 462
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 519
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 520 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 569
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 570 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 607
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 303 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 362
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 404
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 462
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 519
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 520 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 569
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 570 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 607
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 303 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 362
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 404
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 462
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 519
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 520 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 569
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 570 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 607
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 303 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 362
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 404
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 462
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 519
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 520 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 569
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 570 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 607
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 57.8 bits (138), Expect = 6e-08
Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 303 VMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLL 362
++ ++G AG GK+ L +++ W G +RFQ VFY S + ++ +L+
Sbjct: 329 IVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELAQSKVVSLA---ELI 384
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDY-----------KEIC---SIPQ----VIGKL 404
K+G+ T +R I+ + ++LF+LD E+C S PQ ++G L
Sbjct: 385 GKDGTATPAPIRQILSR-PERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSL 443
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLETI--LEIKAFPFYNTVCILRKLFSHNMTRLRK 462
+ K L LI RT +++ LE +E+ F + + F+ +R
Sbjct: 444 LGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRA 503
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNKAT--- 519
F + N+ L + P C Q E+L+L +K T
Sbjct: 504 FRLV-KSNKELWALCLVPWVSWLACTCLMQQ------------MKRKEKLTLTSKTTTTL 550
Query: 520 ----------AEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKF 569
A+ L + LA +G + F+ DDL + G+D T M
Sbjct: 551 CLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL 610
Query: 570 TAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQD 607
+ Y F+ FQEF A M + + R +H +
Sbjct: 611 QEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSN 648
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 55.1 bits (131), Expect = 4e-07
Identities = 83/338 (24%), Positives = 135/338 (39%), Gaps = 49/338 (14%)
Query: 291 LVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR-- 348
L P+ G + ++G G GKT LL K+ W+ +RF FY R
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKI-FRDRFLYTFYFCCRELREL 196
Query: 349 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEI-----------CS- 396
P LA +I + + +TE I+ Q ++LF++D ++E+ C
Sbjct: 197 PPTSLADLISREWPDPAAPITE-----IVSQ-PERLLFVIDSFEELQGGLNEPDSDLCGD 250
Query: 397 ------IPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTV--CI 448
+ ++ L++K L LLIA++ +++R + TI EI +N +
Sbjct: 251 LMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQV-TISEIYQPRGFNESDRLV 309
Query: 449 LRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHW---FQYPFDPSF---DDV 502
F + R + +++ L I + PL +C Q D +
Sbjct: 310 YFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTT 369
Query: 503 AVFKSYMERLSLRNKA------TAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVD 556
+V+ S++ L A T LKA S LA +G ++ FEF +DDL GV
Sbjct: 370 SVYSSFVFNLFTPEGAEGPTPQTQHQLKALCS----LAAEGMWTDTFEFCEDDLRRNGV- 424
Query: 557 EDEDLTMCLMSKFTAQ--RLRPFYRFLSPAFQEFLAGM 592
D D+ L +K + Y FL QEF A +
Sbjct: 425 VDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAAL 462
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 53.5 bits (127), Expect = 1e-06
Identities = 73/325 (22%), Positives = 126/325 (38%), Gaps = 57/325 (17%)
Query: 306 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 365
+EG G GKT LL+K+ WA G +RF VF+L++ G+A +LL ++
Sbjct: 150 LEGPDGIGKTTLLRKVMLDWAEGNL-WKDRFTFVFFLNVCEM---NGIAETSLLELLSRD 205
Query: 366 GSVTEMCVRNIIQQLKNQVLFLL-----------------DDYKEICSIPQVIGKLIQKN 408
+ + +I Q ++LF++ DD+++ +P ++ L+QK
Sbjct: 206 WPESSEKIEDIFSQ-PERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQKK 264
Query: 409 HLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFG 468
L + LLIA L + K + +++ L + F +FG
Sbjct: 265 MLPESSLLIA------------LGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFG 312
Query: 469 KNQSLQKI-----QKTPLFVAA--------ICA---HWFQYPFDPSFDDVAVFKSYMERL 512
+ K+ PLF+ +C + D + Y L
Sbjct: 313 EKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFL 372
Query: 513 SLRNKATAE-----ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMS 567
+ KA ++ + +A + S LA +G ++ F F+ DL G+ E E + M
Sbjct: 373 TTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMR 432
Query: 568 KFTAQRLRPFYRFLSPAFQEFLAGM 592
QR + F+ QEF A M
Sbjct: 433 --LLQRRGDCFAFMHLCIQEFCAAM 455
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 306 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 365
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 366 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 407
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 408 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 465
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 466 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 521
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 522 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 579
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 580 FLSPAFQEFLAGMRLIELLDSDRQEHQD 607
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 306 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 365
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 366 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 407
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 408 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 465
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 466 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 521
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 522 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 579
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 580 FLSPAFQEFLAGMRLIELLDSDRQEHQD 607
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 52.4 bits (124), Expect = 3e-06
Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 38/328 (11%)
Query: 306 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKE 365
+ G AG GKT L KK W C L + FYLS + +L+ K+
Sbjct: 176 LHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKEL---SRMGPCSFAELISKD 230
Query: 366 GSVTEMCVRNIIQQLKNQVLFLLDDYKE-----------ICS-------IPQVIGKLIQK 407
+ + +I+ Q + ++LF++D E IC +P ++G L+++
Sbjct: 231 WPELQDDIPSILAQAQ-RILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKR 289
Query: 408 NHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRKFMV 465
L R LL+ R RD++ + + ++ F + + F +R F +
Sbjct: 290 KMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFEL 349
Query: 466 YFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKS----YMERLSLRNKATAE 521
N +L ++ P +C + + D V + ++ L R A+
Sbjct: 350 -MRSNAALFQLGSAPAVCWIVCT-TLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ 407
Query: 522 ILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQR--LRPFYR 579
L+ + + LA +G ++ F+ +DL GV E DL + L Q + Y
Sbjct: 408 -LRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE-SDLRLFLDGDILRQDRVSKGCYS 465
Query: 580 FLSPAFQEFLAGMRLIELLDSDRQEHQD 607
F+ +FQ+FL L L+ + E +D
Sbjct: 466 FIHLSFQQFLTA--LFYALEKEEGEDRD 491
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 52.4 bits (124), Expect = 3e-06
Identities = 76/322 (23%), Positives = 127/322 (39%), Gaps = 41/322 (12%)
Query: 306 VEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLS---LSSTRPDEGLASIICDQLL 362
++G AG GK++L K+ WA G RF +FY++ ++ + + + +I
Sbjct: 215 MQGAAGIGKSMLAHKVMLDWADGKL-FQGRFDYLFYINCREMNQSATECSMQDLIFSCWP 273
Query: 363 EKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEI---CSIPQ---------------VIGKL 404
E + E+ ++ ++LF++D + E+ PQ ++ L
Sbjct: 274 EPSAPLQELI------RVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSL 327
Query: 405 IQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTRLRK 462
I+K L LLI R + R LE +EI F K F HN + +
Sbjct: 328 IRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYF-HNAEQAGQ 386
Query: 463 FMVYFGKNQSLQKIQKTPLFVAAICAHWFQ------YPFDPSFDDVAVFKSYMERLSLRN 516
Y N+ L + PL +C Q S AV+ Y+ L ++
Sbjct: 387 VFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSL-MQP 445
Query: 517 KATAEILKATVSSCG--ELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ-R 573
K A L+ + G LA G ++ F + DL + G+D ++ M+ F
Sbjct: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
Query: 574 LRPFYRFLSPAFQEFLAGMRLI 595
+Y F+ +FQEF A M I
Sbjct: 506 CERYYSFIHLSFQEFFAAMYYI 527
>gi|59859878 baculoviral IAP repeat-containing protein 5 isoform 1
[Homo sapiens]
Length = 142
Score = 50.8 bits (120), Expect = 8e-06
Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 119 RLDSFKDWP--RESAVGVAALAKAGLFYTGIK---DIVQCFSCGGCLEKWQEGDDPLDDH 173
R+ +FK+WP A +A+AG + + D+ QCF C LE W+ DDP+++H
Sbjct: 18 RISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEH 77
Query: 174 TRCFPNCPFLQNMKSSAEVT 193
+ C FL K E+T
Sbjct: 78 KKHSSGCAFLSVKKQFEELT 97
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 49.7 bits (117), Expect = 2e-05
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 39/352 (11%)
Query: 879 IESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVS------GTIQSQDQI 932
++ + ++ + CS++ + + Q LL L SLE L++S G++ S Q
Sbjct: 191 LQKFQKGSKIQMIELVDCSLTSEDGTFLGQ-LLPMLQSLEVLDLSINRDIVGSLNSIAQG 249
Query: 933 FPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA------EYDPSKLV 986
+ LK S L ++ F + KL + + E P++LV
Sbjct: 250 LKSTSNLKVLKLHSCGLSQKS--VKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV 307
Query: 987 KLIQNSPNLHVFHL-KCNFFSDFGSLMTMLVSC-KKLTEI------KFSDSFFQAVPFVA 1038
L +L V L +C+ +D +T ++ L E+ K S + +
Sbjct: 308 ML----KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLR 363
Query: 1039 SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ 1098
LP SL I N + ET A LS LE L + KL+++ +
Sbjct: 364 FLPALKSLVINNCA----LESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK 419
Query: 1099 QLHCLRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDN 1157
L+VL +L + V +A V +G KL+ L LS N I + G+ F Q +
Sbjct: 420 LSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRF 479
Query: 1158 MPNLQELDIS---RHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDA 1206
+ L ELDIS +F +C + L V +LP++ + M W+L A
Sbjct: 480 LKELIELDISLRPSNFRDC----GQWFRHLLYAVTKLPQITEIGMKRWILPA 527
>gi|153792694 baculoviral IAP repeat-containing 6 [Homo sapiens]
Length = 4857
Score = 48.9 bits (115), Expect = 3e-05
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 11/82 (13%)
Query: 111 SIFAYEELRLDSFKDWPRESAVGVA-----ALAKAGLFYTGIK---DIVQCFSCGGCLEK 162
S+ E R ++F WP VG +A+AG ++ D CF+C CL
Sbjct: 281 SLMYSEANRRETFTSWPH---VGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVC 337
Query: 163 WQEGDDPLDDHTRCFPNCPFLQ 184
W+ D+P +H R PNCPF++
Sbjct: 338 WEPTDEPWSEHERHSPNCPFVK 359
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 307 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 366
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 367 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 401
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 402 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 459
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 460 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 512
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 513 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 572
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 573 -RLRPFYRFLSPAFQEFLAGM 592
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 307 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 366
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 367 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 401
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 402 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 459
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 460 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 512
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 513 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 572
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 573 -RLRPFYRFLSPAFQEFLAGM 592
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 307 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 366
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 367 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 401
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 402 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 459
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 460 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 512
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 513 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 572
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 573 -RLRPFYRFLSPAFQEFLAGM 592
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 307 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 366
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 367 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 401
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 402 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 459
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 460 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 512
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 513 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 572
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 573 -RLRPFYRFLSPAFQEFLAGM 592
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 46.2 bits (108), Expect = 2e-04
Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 48/321 (14%)
Query: 307 EGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEG 366
+G AG GKT+L +K+ WASG +RF +FY+ S++ + L G
Sbjct: 225 QGAAGIGKTILARKMMLDWASGTL-YQDRFDYLFYIHCRE-------VSLVTQRSL---G 273
Query: 367 SVTEMC-------VRNIIQQLKNQVLFLLDDYKE-----------ICSIPQ-------VI 401
+ C + I+++ +++LFL+D + E +C+ Q ++
Sbjct: 274 DLIMSCCPDPNPPIHKIVRK-PSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILL 332
Query: 402 GKLIQKNHLSRTCLLIAVRTNRARDIRRYLE--TILEIKAFPFYNTVCILRKLFSHNMTR 459
LI+K L LLI R ++ L+ +EI F K FS + +
Sbjct: 333 SSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS-DEAQ 391
Query: 460 LRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYP------FDPSFDDVAVFKSYMER-L 512
R +N+ L + PL +C Q S AV+ ++ L
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 513 SLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQ 572
R + L A + LA G ++ F + DL G+ + + M+ F +
Sbjct: 452 QPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKE 511
Query: 573 -RLRPFYRFLSPAFQEFLAGM 592
FY F+ FQEF A M
Sbjct: 512 VDCEKFYSFIHMTFQEFFAAM 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,002,763
Number of Sequences: 37866
Number of extensions: 1868678
Number of successful extensions: 4840
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 4762
Number of HSP's gapped (non-prelim): 96
length of query: 1241
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1127
effective length of database: 13,930,794
effective search space: 15700004838
effective search space used: 15700004838
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.