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Search of human proteins with 119392081
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119392081 complement factor I preproprotein [Homo sapiens]
(583 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119392081 complement factor I preproprotein [Homo sapiens] 1251 0.0
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 184 2e-46
gi|11415040 matriptase [Homo sapiens] 178 1e-44
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 171 1e-42
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 171 2e-42
gi|29244926 corin [Homo sapiens] 159 5e-39
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 156 6e-38
gi|4506143 neurotrypsin precursor [Homo sapiens] 153 5e-37
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 149 5e-36
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 149 9e-36
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 149 9e-36
gi|4503627 coagulation factor XI precursor [Homo sapiens] 145 8e-35
gi|33695155 hepsin [Homo sapiens] 143 4e-34
gi|4504481 hepsin [Homo sapiens] 143 4e-34
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 142 6e-34
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 142 1e-33
gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 140 3e-33
gi|110578663 hypothetical protein LOC203074 [Homo sapiens] 140 3e-33
gi|40254871 transmembrane protease, serine 11E [Homo sapiens] 140 4e-33
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] 140 4e-33
gi|32698940 transmembrane protease, serine 12 [Homo sapiens] 139 7e-33
gi|4505861 plasminogen activator, tissue isoform 1 preproprotein... 138 1e-32
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei... 138 1e-32
gi|223942069 enterokinase precursor [Homo sapiens] 138 2e-32
gi|4506115 protein C [Homo sapiens] 137 2e-32
gi|148613878 acrosin precursor [Homo sapiens] 137 3e-32
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ... 137 4e-32
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ... 137 4e-32
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 135 1e-31
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 134 2e-31
>gi|119392081 complement factor I preproprotein [Homo sapiens]
Length = 583
Score = 1251 bits (3237), Expect = 0.0
Identities = 583/583 (100%), Positives = 583/583 (100%)
Query: 1 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV 60
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
Sbjct: 1 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV 60
Query: 61 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN 120
CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
Sbjct: 61 CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN 120
Query: 121 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE 180
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
Sbjct: 121 TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE 180
Query: 181 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA 240
CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
Sbjct: 181 CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA 240
Query: 241 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA 300
CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA
Sbjct: 241 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVA 300
Query: 301 QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA 360
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
Sbjct: 301 QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA 360
Query: 361 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN 420
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
Sbjct: 361 SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN 420
Query: 421 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER 480
YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
Sbjct: 421 YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER 480
Query: 481 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV 540
VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
Sbjct: 481 VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV 540
Query: 541 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV 583
WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
Sbjct: 541 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV 583
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 184 bits (467), Expect = 2e-46
Identities = 123/392 (31%), Positives = 175/392 (44%), Gaps = 86/392 (21%)
Query: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKA---------------------------- 258
F+C +G + Q + CDG+NDC D+SDEL C +
Sbjct: 363 FRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGR 422
Query: 259 ----------CQGKGFHCKSGVCIPSQY-QCNGEVDCITGEDEVGCAGFASVAQEETEIL 307
C + F C + +C Q +C+G VDC G DE GC S
Sbjct: 423 DEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRS--------- 473
Query: 308 TADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGG 367
+ +H RI+GG G PWQV++ CG
Sbjct: 474 ----------------------SSALH----RIIGGTDTLEGGWPWQVSLHFVGSAYCGA 507
Query: 368 IYIGGCWILTAAHCLRASKTHRYQIWTTVVD-WIHPDLKRIVIEYVDRIIFHENYNAGTY 426
I W+L+AAHC ++ WT + ++ + K + V RI+ HE YN+ T+
Sbjct: 508 SVISREWLLSAAHCFHGNRLSDPTPWTAHLGMYVQGNAK--FVSPVRRIVVHEYYNSQTF 565
Query: 427 QNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGR--EKDNERVFSL 484
DIAL+++ + +L + P C+P + + + C V+GWGR E DN+ L
Sbjct: 566 DYDIALLQLSIAWPETLKQLIQ--PICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVL 623
Query: 485 QWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVW- 541
Q EV+LI C YG M CAG G DACKGDSGGPL C ++ ++
Sbjct: 624 QQAEVELIDQTLCVSTYG--IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILT 681
Query: 542 GVVSWGENCGKPEFPGVYTKVANYFDWISYHV 573
G+VSWG G+P FPGVYT+V+N+ WI +V
Sbjct: 682 GIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYV 713
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 178 bits (452), Expect = 1e-44
Identities = 118/378 (31%), Positives = 172/378 (45%), Gaps = 47/378 (12%)
Query: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCIT 286
F C N CD +NDCGD SDE C +C + F C +G C+ QCNG+ DC
Sbjct: 494 FTCKNKFCKPLFWVCDSVNDCGDNSDEQGC-SCPAQTFRCSNGKCLSKSQQCNGKDDCGD 552
Query: 287 GEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPK-------------------LSC 327
G DE C + ++T R L K C
Sbjct: 553 GSDEASCP--------KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Query: 328 GVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKD-ASGITCGGIYIGGCWILTAAHCLRASK 386
G+ R R+ R+VGG A G+ PWQV++ G CG I W+++AAHC +
Sbjct: 605 GL--RSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662
Query: 387 THRYQI---WTTVVDWIHPDLKR----IVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG 439
RY WT + +H +R + + RII H +N T+ DIAL+E++K
Sbjct: 663 GFRYSDPTQWTAFLG-LHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPA 721
Query: 440 NKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLISN--CS 496
P C+P + ++F V+GWG + LQ GE+++I+ C
Sbjct: 722 EYSSMVRP----ICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCE 777
Query: 497 KFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFP 556
+ + M C G G +D+C+GDSGGPL ++A+ + GVVSWG+ C + P
Sbjct: 778 NLLPQQITPRMM-CVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKP 836
Query: 557 GVYTKVANYFDWISYHVG 574
GVYT++ + DWI + G
Sbjct: 837 GVYTRLPLFRDWIKENTG 854
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 171 bits (434), Expect = 1e-42
Identities = 117/373 (31%), Positives = 177/373 (47%), Gaps = 36/373 (9%)
Query: 215 YTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKS-GVCIP 273
Y Q P +F VNG + ACDG+ DC + DE C C+ F CK CI
Sbjct: 452 YNQSDPCP-GEFLCSVNGLCVP---ACDGVKDCPNGLDERNC-VCRAT-FQCKEDSTCIS 505
Query: 274 SQYQCNGEVDCITGEDE------VGCAGFASVAQEETEILTADMDAERR---RIKSLLPK 324
C+G+ DC+ G DE V C F ++ + + + + R R S
Sbjct: 506 LPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEH 565
Query: 325 LSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRA 384
CG++ RIVGG + G+ PWQ +++ CGG I W++TAAHC +
Sbjct: 566 CDCGLQGPS----SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQE 621
Query: 385 SKTHRYQIWTTVVD--WIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKK 442
+WT + W + V V R++ H + ++ D+AL+++
Sbjct: 622 DSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQL------- 674
Query: 443 DCELPRSI---PACVPWSPYLFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLISN--CS 496
D + RS P C+P + F+P C ++GWG ++ + + LQ +V+LI CS
Sbjct: 675 DHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCS 734
Query: 497 KFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFP 556
+ Y + + M CAG G DAC+GDSGGPLVC + ++ G+VSWG CG+P +
Sbjct: 735 EVYRYQVTPR-MLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYF 793
Query: 557 GVYTKVANYFDWI 569
GVYT++ WI
Sbjct: 794 GVYTRITGVISWI 806
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 171 bits (432), Expect = 2e-42
Identities = 95/245 (38%), Positives = 135/245 (55%), Gaps = 14/245 (5%)
Query: 335 IRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWT 394
+ +RI+GG A+ G PWQV+++ + CGG I WILTAAHC R++ R I T
Sbjct: 182 LSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIAT 241
Query: 395 TVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGN-KKDCELPRSIPAC 453
+ + P L+ V I+ H NY + T++NDIAL+ ++ KD C
Sbjct: 242 SGISTTFPKLRM----RVRNILIHNNYKSATHENDIALVRLENSVTFTKDIH-----SVC 292
Query: 454 VPWSPYLFQPNDTCIVSGWG-REKDNERVFSLQWGEVKLISN--CSKFYG-NRFYEKEME 509
+P + P T V+GWG +E V L+ G+V++ISN C+ + N M
Sbjct: 293 LPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGML 352
Query: 510 CAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWI 569
CAG G +DAC+GDSGGPLV D+ + ++ G+VSWG+ CG P+ PGVYT+V Y DWI
Sbjct: 353 CAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412
Query: 570 SYHVG 574
G
Sbjct: 413 RQQTG 417
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 159 bits (403), Expect = 5e-39
Identities = 121/430 (28%), Positives = 187/430 (43%), Gaps = 49/430 (11%)
Query: 185 HCRGLETSLAECTFTK---RRTMGYQDFADVVCYTQKADSPM--DDFFQCVNGKYISQMK 239
+C E L EC K + T+ F D Y + + DD +C N +S+
Sbjct: 613 NCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDL 672
Query: 240 ACDGINDCGDQSDELCCKACQ----GKGF------HCKSGVCIPSQYQCNGEVDCIT-GE 288
CDG DC D SDE C F + VC + ++ C G
Sbjct: 673 WCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGL 732
Query: 289 DEVGCAGFASVAQEETEILTADMDAE-------------------RRRIKSLLPKLSCGV 329
E ++E LT + E R +I L K CG
Sbjct: 733 GEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGR 792
Query: 330 KNRMHIRRKRIVGGKRAQLGDLPWQVAIK-DASGITCGGIYIGGCWILTAAHCLRASKTH 388
+ + KRI+GG+ ++ G PWQ +++ + SG CG + I W+LT AHC +
Sbjct: 793 RPAARMN-KRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENA 851
Query: 389 RYQIWTTVVDWIHPDLKRIVIE--YVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCEL 446
+W V+ + D + ++ +V II H Y+ DI+++E+ +D + E
Sbjct: 852 A--VWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDIS----ET 905
Query: 447 PRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLIS--NCSKFYGNRFY 504
P C+P +P+ C ++GWG N+ F LQ GEV++IS +C ++ +
Sbjct: 906 GYVRPVCLPNPEQWLEPDTYCYITGWGH-MGNKMPFKLQEGEVRIISLEHCQSYFDMKTI 964
Query: 505 EKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC-GKPEFPGVYTKVA 563
M CAG G++D+C GDSGGPLVC ++G+ SWG C K PGVY+ V+
Sbjct: 965 TTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVS 1024
Query: 564 NYFDWISYHV 573
+ +WI +
Sbjct: 1025 YFVEWIKRQI 1034
Score = 73.2 bits (178), Expect = 6e-13
Identities = 38/99 (38%), Positives = 55/99 (55%), Gaps = 3/99 (3%)
Query: 205 GYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGF 264
GY D D+ Q D +C +G+ I+ CDG +DC D+SDE+ C +C +G
Sbjct: 327 GYDDCGDL-SDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC-SCHSQGL 384
Query: 265 -HCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVAQE 302
C++G CIPS +QC+G+ DC G DE C+ + QE
Sbjct: 385 VECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
Score = 65.1 bits (157), Expect = 2e-10
Identities = 34/100 (34%), Positives = 50/100 (50%), Gaps = 4/100 (4%)
Query: 196 CTFTKRRTMGYQDFADVVCYTQKAD-SPMDDFFQCVNGKYISQMKACDGINDCGDQSDEL 254
C K + GY D D ++ +A + ++ F C GK ++ CDG +DCGD SDE
Sbjct: 282 CIPGKLQCNGYNDCDD---WSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQ 338
Query: 255 CCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCA 294
C C G CI ++ C+G+ DC+ DEV C+
Sbjct: 339 NCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Score = 57.8 bits (138), Expect = 3e-08
Identities = 33/112 (29%), Positives = 42/112 (37%), Gaps = 7/112 (6%)
Query: 183 HVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKY-ISQMKAC 241
H CR +C RR G D D + D ++C + K + C
Sbjct: 584 HFKCRS-----GQCVLASRRCDGQAD-CDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637
Query: 242 DGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
DG DC D DE C CQ C + C+ C+GE DC DE C
Sbjct: 638 DGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 53.9 bits (128), Expect = 4e-07
Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 227 FQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCIT 286
F C +G I C+G NDC D SDE C C FHC +G C+ C+G DC
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCN-CSENLFHCHTGKCLNYSLVCDGYDDCGD 333
Query: 287 GEDEVGC 293
DE C
Sbjct: 334 LSDEQNC 340
Score = 43.5 bits (101), Expect = 5e-04
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 8/73 (10%)
Query: 225 DFFQCVNGKYISQMKACDGINDCGDQSDE----LCCKACQGKGFHCKSGVCIPSQYQCNG 280
DF +C ++ +Q ++ + C E L C +G+ F C SG+CIP + QCNG
Sbjct: 236 DFLRC--SQFRNQTESSNVSRICFSPQQENGKQLLCG--RGENFLCASGICIPGKLQCNG 291
Query: 281 EVDCITGEDEVGC 293
DC DE C
Sbjct: 292 YNDCDDWSDEAHC 304
Score = 37.0 bits (84), Expect = 0.050
Identities = 13/35 (37%), Positives = 19/35 (54%)
Query: 259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
C F C+SG C+ + +C+G+ DC DE C
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 156 bits (394), Expect = 6e-38
Identities = 97/319 (30%), Positives = 148/319 (46%), Gaps = 49/319 (15%)
Query: 259 CQGKGFHCKSGVCIPS-QYQCNGEVDCITGEDEVGCAGFASVAQEETEILTADMDAERRR 317
C G F C + C+ +C+ + DC G DE C
Sbjct: 154 CPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHC------------------------ 189
Query: 318 IKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILT 377
CG++ + RIVGG A G+ PWQ ++++ CG I W+++
Sbjct: 190 --------ECGLQPAWRMAG-RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS 240
Query: 378 AAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKK 437
AAHC + + ++ V V +I+ H YNA T D+A++E+
Sbjct: 241 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS 300
Query: 438 DGNKKDCELP--RSI-PACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLI 492
LP R I P C+P + ++F P+ C++SGWG K++ V LQ V+L+
Sbjct: 301 P-------LPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELL 353
Query: 493 SN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC 550
C+ YG+ ++ M CAG DG +D+C+GDSGGPLVC + + ++ G+VSWG C
Sbjct: 354 DQALCASLYGHSLTDR-MVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGC 412
Query: 551 GKPEFPGVYTKVANYFDWI 569
+ PGVY +V DWI
Sbjct: 413 AEARRPGVYARVTRLRDWI 431
Score = 144 bits (362), Expect = 3e-34
Identities = 85/254 (33%), Positives = 130/254 (51%), Gaps = 14/254 (5%)
Query: 322 LPKLS-CGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAH 380
+PKL CG + M + R+VGG A G++PWQV++K+ S CG +G W+L+AAH
Sbjct: 486 VPKLQECGARPAME-KPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAH 544
Query: 381 CLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGN 440
C +K + + + + I + R++ H YN G D+A++E+
Sbjct: 545 CFNHTKVEQVRAHLGTASLLGLGGSPVKIG-LRRVVLHPLYNPGILDFDLAVLELASP-- 601
Query: 441 KKDCELPRSI-PACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLISN--C 495
+ I P C+P + F C++SGWG ++ LQ V +I C
Sbjct: 602 ---LAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC 658
Query: 496 SKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEF 555
S Y ++ M CAG +G +D+C+GDSGGPL C +A V Y+ G+VSWG C + +
Sbjct: 659 SVLYNFSLTDR-MICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKK 717
Query: 556 PGVYTKVANYFDWI 569
PGVYT++ WI
Sbjct: 718 PGVYTRITRLKGWI 731
Score = 135 bits (341), Expect = 8e-32
Identities = 86/240 (35%), Positives = 122/240 (50%), Gaps = 13/240 (5%)
Query: 339 RIVGGKRAQLGDLPWQVAI-KDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVV 397
RIVGG A G+ PWQV++ CG + + W+L+AAHC + W +
Sbjct: 826 RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQ--WAAFL 883
Query: 398 DWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWS 457
+E V RI H YN T D+AL+E+ G + L R P C+P
Sbjct: 884 GTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELA--GPVRRSRLVR--PICLP-E 938
Query: 458 PYLFQPNDT-CIVSGWGREKDNERVF-SLQWGEVKLISN--CSKFYGNRFYEKEMECAGT 513
P P+ T C+++GWG ++ + LQ V+L+S C +FY + + M CAG
Sbjct: 939 PAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSR-MLCAGF 997
Query: 514 YDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHV 573
G +D+C GD+GGPL C + + + GV SWG CG+P FPGVYT+VA WI H+
Sbjct: 998 PQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHI 1057
>gi|4506143 neurotrypsin precursor [Homo sapiens]
Length = 875
Score = 153 bits (386), Expect = 5e-37
Identities = 144/518 (27%), Positives = 218/518 (42%), Gaps = 79/518 (15%)
Query: 105 TCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGAD 164
+CT + L G EG +EV Q T +C W+ V C LGF+ G
Sbjct: 378 SCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGT--VCDDGWTELNTYVVCRQLGFKYGKQ 435
Query: 165 TQ-RRFKLSDLSINSTECLHVHCRGLETSLAECTFTK--RRTMGYQDFADVVCYT----- 216
F+ S I + V C G ET +C+ + R +++ + CY
Sbjct: 436 ASANHFEESTGPIWLDD---VSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGH 492
Query: 217 --------------QKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGK 262
K + ++ F +NG++ + CD + D+ + C+ K
Sbjct: 493 RLSLGFPVRLMDGENKKEGRVEVF---INGQWGT---ICD--DGWTDKDAAVICRQLGYK 544
Query: 263 G---------FHCKSGVCIPSQYQCNGE----VDCITGEDEVGCAGFASVAQEETEILTA 309
G F G +C G DCI + G + E +
Sbjct: 545 GPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQD-----IGRHNCRHSEDAGVIC 599
Query: 310 DMDAERRRIKSLLPKLS--CGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASG----- 362
D ++ S LS CG++ +H R+KRI+GGK + G PWQV+++ S
Sbjct: 600 DYFGKKASGNSNKESLSSVCGLR-LLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGR 658
Query: 363 ITCGGIYIGGCWILTAAHCLR--ASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN 420
+ CG + CW+LTAAHC + + T Y + + P+ I V +I+ H
Sbjct: 659 LLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIG-VQQIVIHRE 717
Query: 421 YNAGTYQNDIALIEMKKDGNKKDCELPRS--IPACVP-WSPYLFQPNDTCIVSGWGREKD 477
Y DIAL+ ++ G ++ C S +PAC+P W + C ++GWG D
Sbjct: 718 YRPDRSDYDIALVRLQ--GPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWG---D 772
Query: 478 NERVFS--LQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGS--IDACKGDSGGPLVC 531
R +S LQ + L+ C + Y RF + M CAG +D+C+GDSGGPL+C
Sbjct: 773 TGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGR-MLCAGNLHEHKRVDSCQGDSGGPLMC 831
Query: 532 MDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWI 569
V+GV SWG CG + PGVYTKV+ + WI
Sbjct: 832 ERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWI 869
Score = 35.0 bits (79), Expect = 0.19
Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 7/86 (8%)
Query: 113 SVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVAC--LDLGFQQGADTQRRFK 170
SV L+ G + EG VEV T +C S W +A+V C L LG G ++
Sbjct: 169 SVRLRGGKNEFEGTVEVYASGVWGT--VCSSHWDDSDASVICHQLQLG---GKGIAKQTP 223
Query: 171 LSDLSINSTECLHVHCRGLETSLAEC 196
S L + +V CRG E ++ C
Sbjct: 224 FSGLGLIPIYWSNVRCRGDEENILLC 249
Score = 30.8 bits (68), Expect = 3.6
Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 5/103 (4%)
Query: 114 VSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSD 173
+ L G++ EG VE+ Q T +C W +A V C LG A + +
Sbjct: 280 IRLAGGSSVHEGRVELYHAGQWGT--VCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGE 337
Query: 174 LSINSTECLHVHCRGLETSLAECTFTK--RRTMGYQDFADVVC 214
S V C G E S+ +C + G+++ A V C
Sbjct: 338 GS-GPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSC 379
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 149 bits (377), Expect = 5e-36
Identities = 90/238 (37%), Positives = 127/238 (53%), Gaps = 13/238 (5%)
Query: 339 RIVGGKRAQLGDLPWQVAIK---DASGITCGGIYIGGCWILTAAHCLRASKTHR-YQIWT 394
RIVGG + G+ PWQV+++ A CGG IG W+LTAAHC ++I++
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYS 449
Query: 395 TVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACV 454
+++ + K + II H+NY +DIALI+++ N + + P C+
Sbjct: 450 GILN-LSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKP----ICL 504
Query: 455 PWSPYLFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLISN--CSKFYGNRFYEKEMECA 511
P C V+GWG K+ + + LQ + L++N C K Y + + M CA
Sbjct: 505 PSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCA 564
Query: 512 GTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWI 569
G +G DACKGDSGGPLVC N + + G+ SWGE C + E PGVYTKVA Y DWI
Sbjct: 565 GYKEGGKDACKGDSGGPLVCKH-NGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 149 bits (375), Expect = 9e-36
Identities = 113/369 (30%), Positives = 164/369 (44%), Gaps = 37/369 (10%)
Query: 231 NGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCK---------SGVCIPSQYQCNGE 281
+G I+ CDG++ C DE C G F + VC + G
Sbjct: 160 SGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGR 219
Query: 282 VDC---------ITGEDEVGCAGFASVAQEETEILTADM-------DAERRRIKSLLPKL 325
C + + V +G S + T D+ DA + L +
Sbjct: 220 AACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCI 279
Query: 326 SCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRAS 385
+CGV N R+ RIVGG+ A G PWQV++ + CGG I WI+TAAHC+
Sbjct: 280 ACGV-NLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 338
Query: 386 KTHRYQIWTTVVDWIHPDLKRIVIEY-VDRIIFHENYNAGTYQNDIALIEMKKDGNKKDC 444
+ + WT + Y V+++I H NY++ T NDIAL++++K D
Sbjct: 339 LNNPWH-WTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 397
Query: 445 ELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLI--SNC-SKFYG 500
P C+P + QP C +SGWG ++ + L +V LI C S++
Sbjct: 398 VK----PVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVY 453
Query: 501 NRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT 560
+ M CAG G++D+C+GDSGGPLV NN+ ++ G SWG C K PGVY
Sbjct: 454 DNLITPAMICAGFLQGNVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGVYG 512
Query: 561 KVANYFDWI 569
V + DWI
Sbjct: 513 NVMVFTDWI 521
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 149 bits (375), Expect = 9e-36
Identities = 113/369 (30%), Positives = 164/369 (44%), Gaps = 37/369 (10%)
Query: 231 NGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCK---------SGVCIPSQYQCNGE 281
+G I+ CDG++ C DE C G F + VC + G
Sbjct: 123 SGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGR 182
Query: 282 VDC---------ITGEDEVGCAGFASVAQEETEILTADM-------DAERRRIKSLLPKL 325
C + + V +G S + T D+ DA + L +
Sbjct: 183 AACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCI 242
Query: 326 SCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRAS 385
+CGV N R+ RIVGG+ A G PWQV++ + CGG I WI+TAAHC+
Sbjct: 243 ACGV-NLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 301
Query: 386 KTHRYQIWTTVVDWIHPDLKRIVIEY-VDRIIFHENYNAGTYQNDIALIEMKKDGNKKDC 444
+ + WT + Y V+++I H NY++ T NDIAL++++K D
Sbjct: 302 LNNPWH-WTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL 360
Query: 445 ELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLI--SNC-SKFYG 500
P C+P + QP C +SGWG ++ + L +V LI C S++
Sbjct: 361 VK----PVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVY 416
Query: 501 NRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT 560
+ M CAG G++D+C+GDSGGPLV NN+ ++ G SWG C K PGVY
Sbjct: 417 DNLITPAMICAGFLQGNVDSCQGDSGGPLV-TSKNNIWWLIGDTSWGSGCAKAYRPGVYG 475
Query: 561 KVANYFDWI 569
V + DWI
Sbjct: 476 NVMVFTDWI 484
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 145 bits (367), Expect = 8e-35
Identities = 110/329 (33%), Positives = 156/329 (47%), Gaps = 31/329 (9%)
Query: 250 QSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVAQEETEILTA 309
+S E C K C C+ P+Q CN E + C S T+IL
Sbjct: 312 KSHEACQKLCTN-AVRCQFFTYTPAQASCN--------EGKGKCYLKLSSNGSPTKILHG 362
Query: 310 DMDAERRRIKSLLPKLSCGVKNRMHIRRK-RIVGGKRAQLGDLPWQVAIKDASGIT---C 365
R I +L C + N + K RIVGG + G+ PWQV + S C
Sbjct: 363 -----RGGISGYTLRL-CKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLC 416
Query: 366 GGIYIGGCWILTAAHCLRASKTHRY-QIWTTVVDWIHPDLKRIVIEY-VDRIIFHENYNA 423
GG IG WILTAAHC ++ + ++++ +++ ++K + V II H+ Y
Sbjct: 417 GGSIIGNQWILTAAHCFYGVESPKILRVYSGILN--QSEIKEDTSFFGVQEIIIHDQYKM 474
Query: 424 GTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS 483
DIAL++++ N D + P C+P C V+GWG K +++ +
Sbjct: 475 AESGYDIALLKLETTVNYTDSQRP----ICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQN 530
Query: 484 -LQWGEVKLISN--CSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV 540
LQ ++ L++N C K Y +M CAG +G DACKGDSGGPL C N V ++
Sbjct: 531 TLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKH-NEVWHL 589
Query: 541 WGVVSWGENCGKPEFPGVYTKVANYFDWI 569
G+ SWGE C + E PGVYT V Y DWI
Sbjct: 590 VGITSWGEGCAQRERPGVYTNVVEYVDWI 618
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 143 bits (361), Expect = 4e-34
Identities = 91/250 (36%), Positives = 131/250 (52%), Gaps = 30/250 (12%)
Query: 339 RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCL--RASKTHRYQIWTTV 396
RIVGG+ LG PWQV+++ CGG + G W+LTAAHC R R++++
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
Query: 397 VDWIHPDLKRIVIEYVDRIIFHENY------NAGTYQNDIALIEMKKDGNKKDCELPRS- 449
V P ++ ++ +++H Y N+ NDIAL+ + LP +
Sbjct: 222 VAQASPHGLQLGVQ---AVVYHGGYLPFRDPNSEENSNDIALVHLSS-------PLPLTE 271
Query: 450 --IPACVPWSPYLFQPNDTCIVSGWGR-EKDNERVFSLQWGEVKLISN--C--SKFYGNR 502
P C+P + C V+GWG + ++ LQ V +ISN C + FYGN+
Sbjct: 272 YIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQ 331
Query: 503 FYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVW---GVVSWGENCGKPEFPGVY 559
K M CAG +G IDAC+GDSGGP VC D+ + T W G+VSWG C + PGVY
Sbjct: 332 IKPK-MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
Query: 560 TKVANYFDWI 569
TKV+++ +WI
Sbjct: 391 TKVSDFREWI 400
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 143 bits (361), Expect = 4e-34
Identities = 91/250 (36%), Positives = 131/250 (52%), Gaps = 30/250 (12%)
Query: 339 RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCL--RASKTHRYQIWTTV 396
RIVGG+ LG PWQV+++ CGG + G W+LTAAHC R R++++
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
Query: 397 VDWIHPDLKRIVIEYVDRIIFHENY------NAGTYQNDIALIEMKKDGNKKDCELPRS- 449
V P ++ ++ +++H Y N+ NDIAL+ + LP +
Sbjct: 222 VAQASPHGLQLGVQ---AVVYHGGYLPFRDPNSEENSNDIALVHLSS-------PLPLTE 271
Query: 450 --IPACVPWSPYLFQPNDTCIVSGWGR-EKDNERVFSLQWGEVKLISN--C--SKFYGNR 502
P C+P + C V+GWG + ++ LQ V +ISN C + FYGN+
Sbjct: 272 YIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQ 331
Query: 503 FYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVW---GVVSWGENCGKPEFPGVY 559
K M CAG +G IDAC+GDSGGP VC D+ + T W G+VSWG C + PGVY
Sbjct: 332 IKPK-MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
Query: 560 TKVANYFDWI 569
TKV+++ +WI
Sbjct: 391 TKVSDFREWI 400
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 142 bits (359), Expect = 6e-34
Identities = 91/239 (38%), Positives = 119/239 (49%), Gaps = 15/239 (6%)
Query: 339 RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVD 398
RIVGG+ G PWQ ++ TCGG + W++TAAHC+ + + R W
Sbjct: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276
Query: 399 WI-HPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPA-CVPW 456
+ H ++ V+RII H Y+A + D+AL+ ++ N D ++ A C+P
Sbjct: 277 LVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSD-----TVGAVCLPA 331
Query: 457 SPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLIS----NCSKFYGNRFYEKEMEC 510
F C VSGWG + S LQ V L S N S Y + M C
Sbjct: 332 KEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPR-MLC 390
Query: 511 AGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWI 569
AG DG DAC+GDSGGPLVC D + V GVVSWG C +P PGVY KVA + DWI
Sbjct: 391 AGYLDGRADACQGDSGGPLVCPDGDTWRLV-GVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 142 bits (357), Expect = 1e-33
Identities = 89/244 (36%), Positives = 130/244 (53%), Gaps = 12/244 (4%)
Query: 335 IRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWT 394
I +IV GK + G PWQ +++ CG I W+L+AAHC +K + + WT
Sbjct: 180 ITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCF--AKKNNSKDWT 237
Query: 395 TVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACV 454
V++ K + V IIFHENY++ +DIAL+++ ++ + E R I C+
Sbjct: 238 --VNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFT--EYIRKI--CL 291
Query: 455 PWSPYLFQPNDTCIVSGWGREKDNERV-FSLQWGEVKLISN--CSKFYG-NRFYEKEMEC 510
P + ND +V+GWG N LQ +K+I N C+ Y + F M C
Sbjct: 292 PEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLC 351
Query: 511 AGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWIS 570
AG G DAC+ DSGGPL D+ N+ ++ G+VSWG+ CGK PGVYT+V +Y +WI+
Sbjct: 352 AGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWIT 411
Query: 571 YHVG 574
G
Sbjct: 412 SKTG 415
>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
Length = 438
Score = 140 bits (353), Expect = 3e-33
Identities = 92/244 (37%), Positives = 131/244 (53%), Gaps = 17/244 (6%)
Query: 338 KRIVGGKRAQL-GDLPWQVAIK-DASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTT 395
+RIV G+ + G+ PWQ +++ SG CG I W+LTAAHC +K I T
Sbjct: 204 QRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATF 263
Query: 396 VVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIP-ACV 454
P +KR V +II HENY+ T +NDIAL+++ E + C+
Sbjct: 264 GATITPPAVKR----NVRKIILHENYHRETNENDIALVQLSTG-----VEFSNIVQRVCL 314
Query: 455 PWSPYLFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLISN--CS-KFYGNRFYEKEMEC 510
P S P + V+G+G D+ + + L+ V+ IS C+ K + M C
Sbjct: 315 PDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLC 374
Query: 511 AGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWIS 570
AG +G IDACKGDSGGPLV D +++ Y+ G+VSWG++C P+ PGVYT+V Y DWI+
Sbjct: 375 AGFMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIA 433
Query: 571 YHVG 574
G
Sbjct: 434 SKTG 437
>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
Length = 352
Score = 140 bits (353), Expect = 3e-33
Identities = 93/274 (33%), Positives = 136/274 (49%), Gaps = 35/274 (12%)
Query: 323 PKLSCGVKNRMHIRRK--RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAH 380
P CG ++ R + RI GG A++G+ PWQV+I+ S CGG + WILTAAH
Sbjct: 49 PVSECGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAH 108
Query: 381 CLRASKTHRYQIWTTV--VDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKD 438
CL + + ++ + D P ++ I+ V II H+++ NDIAL+ +
Sbjct: 109 CLYSEELFPEELSVVLGTNDLTSPSME---IKEVASIILHKDFKRANMDNDIALLLLASP 165
Query: 439 GNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER-----------VFSLQWG 487
D + +P C+P P + C V+GWG+ ++ + + W
Sbjct: 166 IKLDDLK----VPICLPTQPGPATWRE-CWVAGWGQTNAADKNSVKTDLMKAPMVIMDWE 220
Query: 488 EVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCM-DANNVTYVWGVVSW 546
E CSK + K M CAG + S DACKGDSGGPLVC + Y G++SW
Sbjct: 221 E------CSKMFPK--LTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISW 272
Query: 547 GENCGKPEFPGVYTKVANYFDWI---SYHVGRPF 577
G++CG+ PG+YT + NY WI + GRPF
Sbjct: 273 GKSCGEKNTPGIYTSLVNYNLWIEKVTQLEGRPF 306
>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
Length = 423
Score = 140 bits (352), Expect = 4e-33
Identities = 88/253 (34%), Positives = 126/253 (49%), Gaps = 13/253 (5%)
Query: 327 CGVKNRMHIRRK-RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRAS 385
CG + + + RIVGG + G+ PWQ +++ CG I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 386 KTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCE 445
K + V +KR + RII HE Y ++ DI+L E+ +
Sbjct: 238 KNPARWTASFGVTIKPSKMKR----GLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
Query: 446 LPRSIPACVPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLI--SNCSKFYG-N 501
C+P + Y FQP D V+G+G K D L+ +V LI + C++ N
Sbjct: 294 HR----VCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYN 349
Query: 502 RFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTK 561
M CAG+ +G DAC+GDSGGPLV DA ++ Y+ G+VSWG+ C KP PGVYT+
Sbjct: 350 DAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTR 409
Query: 562 VANYFDWISYHVG 574
V DWI+ G
Sbjct: 410 VTALRDWITSKTG 422
>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
Length = 423
Score = 140 bits (352), Expect = 4e-33
Identities = 88/253 (34%), Positives = 126/253 (49%), Gaps = 13/253 (5%)
Query: 327 CGVKNRMHIRRK-RIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRAS 385
CG + + + RIVGG + G+ PWQ +++ CG I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 386 KTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCE 445
K + V +KR + RII HE Y ++ DI+L E+ +
Sbjct: 238 KNPARWTASFGVTIKPSKMKR----GLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAV 293
Query: 446 LPRSIPACVPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLI--SNCSKFYG-N 501
C+P + Y FQP D V+G+G K D L+ +V LI + C++ N
Sbjct: 294 HR----VCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYN 349
Query: 502 RFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTK 561
M CAG+ +G DAC+GDSGGPLV DA ++ Y+ G+VSWG+ C KP PGVYT+
Sbjct: 350 DAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTR 409
Query: 562 VANYFDWISYHVG 574
V DWI+ G
Sbjct: 410 VTALRDWITSKTG 422
>gi|32698940 transmembrane protease, serine 12 [Homo sapiens]
Length = 348
Score = 139 bits (350), Expect = 7e-33
Identities = 92/254 (36%), Positives = 128/254 (50%), Gaps = 26/254 (10%)
Query: 335 IRRKRIVGGKRAQLGDLPWQVAIKDASGIT----CGGIYIGGCWILTAAHCLRASKTHRY 390
++ RI+GG AQ G PW V+++ G CGG + W+LTAAHC + +
Sbjct: 73 LQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPL- 131
Query: 391 QIWTTVVDW--IH---PDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCE 445
+WT V+ IH P K+I I+ II H N+ +Y NDIAL +KK D
Sbjct: 132 -MWTAVIGTNNIHGRYPHTKKIKIK---AIIIHPNFILESYVNDIALFHLKKAVRYNDYI 187
Query: 446 LPRSIPACVPWSPY-LFQPNDTCIVSGWGREKDNERVFS-LQWGEVKLIS----NCSKFY 499
P C+P+ + + N C +SGWGR K+ + LQ EV IS N + Y
Sbjct: 188 QP----ICLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSY 243
Query: 500 GNRFYEKEMECAGTYDGSIDACKGDSGGPLVC-MDANNVTYVWGVVSWGENCGKPEFPGV 558
G CAG DG+ D C+GDSGGPL+C + +V G+ S+G CG+ FPGV
Sbjct: 244 GGIIPNTSF-CAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGV 302
Query: 559 YTKVANYFDWISYH 572
Y + Y W++ H
Sbjct: 303 YIGPSFYQKWLTEH 316
>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
[Homo sapiens]
Length = 562
Score = 138 bits (348), Expect = 1e-32
Identities = 92/249 (36%), Positives = 126/249 (50%), Gaps = 20/249 (8%)
Query: 339 RIVGGKRAQLGDLPWQVAI------KDASGITCGGIYIGGCWILTAAHCLRAS-KTHRYQ 391
RI GG A + PWQ AI CGGI I CWIL+AAHC + H
Sbjct: 310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT 369
Query: 392 IWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIP 451
+ + P + E V++ I H+ ++ TY NDIAL+++K D ++ E
Sbjct: 370 VILGRTYRVVPGEEEQKFE-VEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRT 428
Query: 452 ACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLI--SNC-SKFYGNRFYEK 506
C+P + C +SG+G+ + +S L+ V+L S C S+ NR
Sbjct: 429 VCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTD 488
Query: 507 EMECAG-TYDGSI-----DACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT 560
M CAG T G DAC+GDSGGPLVC++ +T V G++SWG CG+ + PGVYT
Sbjct: 489 NMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLV-GIISWGLGCGQKDVPGVYT 547
Query: 561 KVANYFDWI 569
KV NY DWI
Sbjct: 548 KVTNYLDWI 556
>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
[Homo sapiens]
Length = 516
Score = 138 bits (348), Expect = 1e-32
Identities = 92/249 (36%), Positives = 126/249 (50%), Gaps = 20/249 (8%)
Query: 339 RIVGGKRAQLGDLPWQVAI------KDASGITCGGIYIGGCWILTAAHCLRAS-KTHRYQ 391
RI GG A + PWQ AI CGGI I CWIL+AAHC + H
Sbjct: 264 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT 323
Query: 392 IWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIP 451
+ + P + E V++ I H+ ++ TY NDIAL+++K D ++ E
Sbjct: 324 VILGRTYRVVPGEEEQKFE-VEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRT 382
Query: 452 ACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLI--SNC-SKFYGNRFYEK 506
C+P + C +SG+G+ + +S L+ V+L S C S+ NR
Sbjct: 383 VCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTD 442
Query: 507 EMECAG-TYDGSI-----DACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT 560
M CAG T G DAC+GDSGGPLVC++ +T V G++SWG CG+ + PGVYT
Sbjct: 443 NMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLV-GIISWGLGCGQKDVPGVYT 501
Query: 561 KVANYFDWI 569
KV NY DWI
Sbjct: 502 KVTNYLDWI 510
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 138 bits (347), Expect = 2e-32
Identities = 109/376 (28%), Positives = 165/376 (43%), Gaps = 38/376 (10%)
Query: 225 DFFQCVNGKYISQMKACDGINDCGDQSDEL-CCKACQGKG-------FHCKS---GVCIP 273
D FQC NG+ + + CDG C D SDE C + G F +S C
Sbjct: 646 DHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAE 705
Query: 274 S-QYQCNGEVDCITG-----------EDEVGCAGFASVAQEETEILTADMDA-ERRRIKS 320
+ Q + +V + G + G + A + ILT + I+
Sbjct: 706 NWTTQISNDVCQLLGLGSGNSSKPIFSTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRL 765
Query: 321 LLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAH 380
SCG K +IVGG A+ G PW V + + CG + W+++AAH
Sbjct: 766 QCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAH 825
Query: 381 CLRASKTHRYQIWTTVVDWIHPDLK----RIVIEYVDRIIFHENYNAGTYQNDIALIEMK 436
C+ + WT ++ +H + V +D I+ + +YN NDIA++ ++
Sbjct: 826 CVYGRNLEPSK-WTAILG-LHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLE 883
Query: 437 KDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGR-EKDNERVFSLQWGEVKLISN- 494
N D P C+P +F P C ++GWG LQ +V L+SN
Sbjct: 884 FKVNYTD----YIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNE 939
Query: 495 -CSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKP 553
C + + M CAG +G ID+C+GDSGGPL+C + NN ++ GV S+G C P
Sbjct: 940 RCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFGYKCALP 998
Query: 554 EFPGVYTKVANYFDWI 569
PGVY +V+ + +WI
Sbjct: 999 NRPGVYARVSRFTEWI 1014
Score = 29.6 bits (65), Expect = 8.0
Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 11/87 (12%)
Query: 187 RGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKY-----ISQMKA- 240
+GLE + + T + D D + T +P + +C+ G ++ +KA
Sbjct: 142 QGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKAD 201
Query: 241 --CDGINDCGDQSDE---LCCKACQGK 262
CDG +C D SDE +C C G+
Sbjct: 202 LFCDGEVNCPDGSDEDNKMCATVCDGR 228
>gi|4506115 protein C [Homo sapiens]
Length = 461
Score = 137 bits (346), Expect = 2e-32
Identities = 89/273 (32%), Positives = 129/273 (47%), Gaps = 44/273 (16%)
Query: 330 KNRMHIRRK----------RIVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTA 378
K R H++R R++ GK + GD PWQV + D+ + CG + I W+LTA
Sbjct: 192 KKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTA 251
Query: 379 AHCLRASKT----------HRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQN 428
AHC+ SK R++ W +D + + H NY+ T N
Sbjct: 252 AHCMDESKKLLVRLGEYDLRRWEKWELDLD-------------IKEVFVHPNYSKSTTDN 298
Query: 429 DIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWG----REKD--NERVF 482
DIAL+ + + +P +P L Q +V+GWG REK+ R F
Sbjct: 299 DIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTF 358
Query: 483 SLQWGEVKLI--SNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV 540
L + ++ ++ + CS+ N E M CAG DAC+GDSGGP+V + ++
Sbjct: 359 VLNFIKIPVVPHNECSEVMSNMVSEN-MLCAGILGDRQDACEGDSGGPMVA-SFHGTWFL 416
Query: 541 WGVVSWGENCGKPEFPGVYTKVANYFDWISYHV 573
G+VSWGE CG GVYTKV+ Y DWI H+
Sbjct: 417 VGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHI 449
>gi|148613878 acrosin precursor [Homo sapiens]
Length = 421
Score = 137 bits (345), Expect = 3e-32
Identities = 94/268 (35%), Positives = 137/268 (51%), Gaps = 26/268 (9%)
Query: 327 CGVKNRMHIRRK-RIVGGKRAQLGDLPWQVAIK-----DASGITCGGIYIGGCWILTAAH 380
CG++ R + + RIVGGK AQ G PW V+++ TCGG + W+LTAAH
Sbjct: 29 CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
Query: 381 C-LRASKTHRYQIWTTVVDWIHPDLKRIVI----EYVDRIIFHENYNAGTYQNDIALIEM 435
C + + H +++ + + + K + YV++II HE YN+ T NDIAL+E+
Sbjct: 89 CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148
Query: 436 KKDGNKKDCELPRSI-PACVP-WSPYLFQPNDTCIVSGWG--REKDNERVFSLQWGEVKL 491
R I P C+P + L + + +C V+GWG EK L V L
Sbjct: 149 TPP-----ISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDL 203
Query: 492 IS----NCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTY-VWGVVSW 546
I N +++Y R + CAG G ID C+GDSGGPL+C D+ Y V G+ SW
Sbjct: 204 IDLDLCNSTQWYNGRVQPTNV-CAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSW 262
Query: 547 GENCGKPEFPGVYTKVANYFDWISYHVG 574
G C + + PG+YT Y +WI+ +G
Sbjct: 263 GVGCARAKRPGIYTATWPYLNWIASKIG 290
>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
sapiens]
Length = 418
Score = 137 bits (344), Expect = 4e-32
Identities = 95/264 (35%), Positives = 135/264 (51%), Gaps = 25/264 (9%)
Query: 321 LLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAH 380
L + SCG K + + RI G A PWQ +++ + CG I W++TAAH
Sbjct: 169 LTVQASCG-KRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAH 227
Query: 381 CLRASKTHRYQIWTTVVDW-IHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG 439
C + K WT I+P L + V R I HE Y + + DIA++++
Sbjct: 228 CFQKYKNPHQ--WTVSFGTKINPPLMK---RNVRRFIIHEKYRSAAREYDIAVVQVSSRV 282
Query: 440 NKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGR-----EKDNERVFSLQWGEVKLISN 494
D R I C+P + FQPN T ++G+G E N+ L+ VK+IS+
Sbjct: 283 TFSDDI--RQI--CLPEASASFQPNLTVHITGFGALYYGGESQND----LREARVKIISD 334
Query: 495 --CSK--FYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC 550
C + YGN + M CAG +G DAC+GDSGGPLV D + Y+ G+VSWG+NC
Sbjct: 335 DVCKQPQVYGNDI-KPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 393
Query: 551 GKPEFPGVYTKVANYFDWISYHVG 574
G+ + PGVYT+V Y +WI+ G
Sbjct: 394 GQKDKPGVYTQVTYYRNWIASKTG 417
>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
sapiens]
Length = 421
Score = 137 bits (344), Expect = 4e-32
Identities = 95/264 (35%), Positives = 135/264 (51%), Gaps = 25/264 (9%)
Query: 321 LLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAH 380
L + SCG K + + RI G A PWQ +++ + CG I W++TAAH
Sbjct: 172 LTVQASCG-KRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAH 230
Query: 381 CLRASKTHRYQIWTTVVDW-IHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG 439
C + K WT I+P L + V R I HE Y + + DIA++++
Sbjct: 231 CFQKYKNPHQ--WTVSFGTKINPPLMK---RNVRRFIIHEKYRSAAREYDIAVVQVSSRV 285
Query: 440 NKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGR-----EKDNERVFSLQWGEVKLISN 494
D R I C+P + FQPN T ++G+G E N+ L+ VK+IS+
Sbjct: 286 TFSDDI--RQI--CLPEASASFQPNLTVHITGFGALYYGGESQND----LREARVKIISD 337
Query: 495 --CSK--FYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENC 550
C + YGN + M CAG +G DAC+GDSGGPLV D + Y+ G+VSWG+NC
Sbjct: 338 DVCKQPQVYGNDI-KPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNC 396
Query: 551 GKPEFPGVYTKVANYFDWISYHVG 574
G+ + PGVYT+V Y +WI+ G
Sbjct: 397 GQKDKPGVYTQVTYYRNWIASKTG 420
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 135 bits (339), Expect = 1e-31
Identities = 113/358 (31%), Positives = 156/358 (43%), Gaps = 43/358 (12%)
Query: 241 CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQ----CNGEVDCITGEDEVGCAGF 296
CDG+ DC +SDEL C K + S +Q C+ + E GF
Sbjct: 211 CDGVVDCKLKSDELGCVRFDWDKSLLK--IYSGSSHQWLPICSSNWNDSYSEKTCQQLGF 268
Query: 297 ASVAQEETEILTADMDAE------RRRIKSLLPKLSCGVKNRMHIRRK---------RIV 341
S A TE+ D I+ L + C + + ++ RIV
Sbjct: 269 ES-AHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIV 327
Query: 342 GGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIH 401
GG A PWQV++ + CGG I W+LTAAHC ++ + W +
Sbjct: 328 GGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSN 387
Query: 402 ----PDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI-PACVPW 456
P+ I II + NY DIAL+ + K L I PAC+P
Sbjct: 388 LHQLPEAASIA-----EIIINSNYTDEEDDYDIALMRL-----SKPLTLSAHIHPACLPM 437
Query: 457 SPYLFQPNDTCIVSGWG--REKDNERVFSLQWGEVKLI--SNCSKF-YGNRFYEKEMECA 511
F N+TC ++G+G RE D++ L+ +V LI C+ + + + M CA
Sbjct: 438 HGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCA 497
Query: 512 GTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWI 569
G G D+C+GDSGGPLVC + NN Y+ GV SWG CG+ PGVYTKV WI
Sbjct: 498 GDLRGGRDSCQGDSGGPLVC-EQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 134 bits (337), Expect = 2e-31
Identities = 114/378 (30%), Positives = 157/378 (41%), Gaps = 46/378 (12%)
Query: 233 KYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVG 292
K I + CDG++DC D DE C G+ + + C+ D V
Sbjct: 84 KCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSD--DWKGHYANVA 141
Query: 293 CA--GFASVAQEETEILTADMDAERRR----IKSLLPK---------------------- 324
CA GF S + + + ++ + R I LLP
Sbjct: 142 CAQLGFPSYVSSDN-LRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVV 200
Query: 325 -LSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLR 383
L C RIVGG + L PWQ +++ CGG I WI+TAAHC+
Sbjct: 201 TLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCV- 259
Query: 384 ASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKD 443
+ + WT V + V++I++H Y NDIAL MK G
Sbjct: 260 -YDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIAL--MKLAGPLTF 316
Query: 444 CELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLISN--CS--K 497
E+ + P C+P S F C SGWG +D S L V LISN C+
Sbjct: 317 NEMIQ--PVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRD 374
Query: 498 FYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPG 557
YG M CAG G +D+C+GDSGGPLVC + + + G S+G C + PG
Sbjct: 375 VYGG-IISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPG 432
Query: 558 VYTKVANYFDWISYHVGR 575
VYT+V ++ DWI + R
Sbjct: 433 VYTRVTSFLDWIHEQMER 450
Score = 31.6 bits (70), Expect = 2.1
Identities = 16/36 (44%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 259 CQGKGFHCKSGV-CIPSQYQCNGEVDCITGEDEVGC 293
C GK + C+S CI +C+G DC GEDE C
Sbjct: 73 CSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.457
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,447,478
Number of Sequences: 37866
Number of extensions: 1186564
Number of successful extensions: 3907
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 2487
Number of HSP's gapped (non-prelim): 732
length of query: 583
length of database: 18,247,518
effective HSP length: 108
effective length of query: 475
effective length of database: 14,157,990
effective search space: 6725045250
effective search space used: 6725045250
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.