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Search of human proteins with 118600977
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain
containing 8 [Homo sapiens]
(1932 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain conta... 3924 0.0
gi|227430303 CD109 antigen isoform 3 precursor [Homo sapiens] 329 1e-89
gi|115529484 CD109 antigen isoform 1 precursor [Homo sapiens] 329 1e-89
gi|227430301 CD109 antigen isoform 2 precursor [Homo sapiens] 315 2e-85
gi|66932947 alpha-2-macroglobulin precursor [Homo sapiens] 313 8e-85
gi|162809334 pregnancy-zone protein [Homo sapiens] 308 3e-83
gi|74271845 alpha-2-macroglobulin-like 1 [Homo sapiens] 302 2e-81
gi|178557739 complement component 4B preproprotein [Homo sapiens] 236 2e-61
gi|239740684 PREDICTED: similar to C4A protein isoform 1 [Homo s... 235 3e-61
gi|67190748 complement component 4A preproprotein [Homo sapiens] 234 5e-61
gi|239740686 PREDICTED: similar to C4A protein isoform 2 [Homo s... 218 5e-56
gi|115298678 complement component 3 precursor [Homo sapiens] 183 2e-45
gi|239744583 PREDICTED: ovostatin 2 [Homo sapiens] 181 6e-45
gi|169204289 PREDICTED: ovostatin [Homo sapiens] 179 2e-44
gi|239758130 PREDICTED: similar to complement component 4B (Chil... 168 5e-41
gi|38016947 complement component 5 preproprotein [Homo sapiens] 145 3e-34
gi|169218213 PREDICTED: similar to complement component C3, part... 140 2e-32
gi|239750255 PREDICTED: similar to ovostatin-2 [Homo sapiens] 117 1e-25
gi|169217711 PREDICTED: similar to Ovostatin homolog 2 [Homo sap... 79 4e-14
gi|239754277 PREDICTED: similar to Complement component 4A (Rodg... 67 2e-10
gi|54873613 agrin [Homo sapiens] 61 1e-08
gi|169214179 PREDICTED: similar to complement component 3 [Homo ... 58 8e-08
gi|239755748 PREDICTED: ovostatin [Homo sapiens] 55 7e-07
gi|239752557 PREDICTED: similar to Ovostatin homolog 2 [Homo sap... 54 1e-06
gi|169205183 PREDICTED: similar to hCG38149 [Homo sapiens] 46 4e-04
gi|239744557 PREDICTED: hypothetical protein LOC728715 [Homo sap... 46 4e-04
gi|12383051 transmembrane protein with EGF-like and two follista... 44 0.002
gi|29568105 transmembrane protein with EGF-like and two follista... 42 0.004
gi|169217713 PREDICTED: similar to Ovostatin homolog 2 [Homo sap... 42 0.008
gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens] 41 0.013
>gi|118600977 C3 and PZP-like, alpha-2-macroglobulin domain containing
8 [Homo sapiens]
Length = 1932
Score = 3924 bits (10176), Expect = 0.0
Identities = 1932/1932 (100%), Positives = 1932/1932 (100%)
Query: 1 MAPGALRGGCEQRAPGGGARTAALGPWPWPSPGPAPSPGAAPPRSRKMSGALLWPLLPLL 60
MAPGALRGGCEQRAPGGGARTAALGPWPWPSPGPAPSPGAAPPRSRKMSGALLWPLLPLL
Sbjct: 1 MAPGALRGGCEQRAPGGGARTAALGPWPWPSPGPAPSPGAAPPRSRKMSGALLWPLLPLL 60
Query: 61 LLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPV 120
LLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPV
Sbjct: 61 LLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPV 120
Query: 121 VQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQ 180
VQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQ
Sbjct: 121 VQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQ 180
Query: 181 TDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSF 240
TDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSF
Sbjct: 181 TDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSF 240
Query: 241 PLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRAR 300
PLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRAR
Sbjct: 241 PLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRAR 300
Query: 301 YTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFR 360
YTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFR
Sbjct: 301 YTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIPADVPEHFR 360
Query: 361 GRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDG 420
GRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDG
Sbjct: 361 GRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDG 420
Query: 421 SPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPV 480
SPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPV
Sbjct: 421 SPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPV 480
Query: 481 GAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGN 540
GAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGN
Sbjct: 481 GAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGN 540
Query: 541 IVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSM 600
IVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSM
Sbjct: 541 IVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSM 600
Query: 601 VPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSC 660
VPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSC
Sbjct: 601 VPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSC 660
Query: 661 VCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSS 720
VCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSS
Sbjct: 661 VCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSS 720
Query: 721 VFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPS 780
VFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPS
Sbjct: 721 VFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPS 780
Query: 781 RHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI 840
RHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI
Sbjct: 781 RHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI 840
Query: 841 AEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHP 900
AEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHP
Sbjct: 841 AEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHP 900
Query: 901 GKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHA 960
GKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHA
Sbjct: 901 GKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHA 960
Query: 961 DRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRF 1020
DRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRF
Sbjct: 961 DRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRF 1020
Query: 1021 DVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWD 1080
DVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWD
Sbjct: 1021 DVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSWD 1080
Query: 1081 EFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKM 1140
EFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKM
Sbjct: 1081 EFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKM 1140
Query: 1141 EVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFA 1200
EVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFA
Sbjct: 1141 EVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFA 1200
Query: 1201 PNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTA 1260
PNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTA
Sbjct: 1201 PNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTA 1260
Query: 1261 FVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTA 1320
FVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTA
Sbjct: 1261 FVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTA 1320
Query: 1321 YVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALR 1380
YVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALR
Sbjct: 1321 YVVVALLETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALR 1380
Query: 1381 KLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDV 1440
KLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDV
Sbjct: 1381 KLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDV 1440
Query: 1441 AAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQE 1500
AAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQE
Sbjct: 1441 AAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQE 1500
Query: 1501 TFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQ 1560
TFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQ
Sbjct: 1501 TFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQ 1560
Query: 1561 EPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAV 1620
EPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAV
Sbjct: 1561 EPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAV 1620
Query: 1621 LEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALREC 1680
LEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALREC
Sbjct: 1621 LEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALREC 1680
Query: 1681 VVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPG 1740
VVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPG
Sbjct: 1681 VVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPG 1740
Query: 1741 ESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPP 1800
ESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPP
Sbjct: 1741 ESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPP 1800
Query: 1801 SCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAG 1860
SCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAG
Sbjct: 1801 SCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAG 1860
Query: 1861 PRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVYSPAFQSGGE 1920
PRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVYSPAFQSGGE
Sbjct: 1861 PRPPVSSGNLESSTQSASPFHRWGQTPAPQRHSGRVVGAHRPGLLSPVFVYSPAFQSGGE 1920
Query: 1921 EGLWMSNTCTLR 1932
EGLWMSNTCTLR
Sbjct: 1921 EGLWMSNTCTLR 1932
>gi|227430303 CD109 antigen isoform 3 precursor [Homo sapiens]
Length = 1368
Score = 329 bits (844), Expect = 1e-89
Identities = 209/567 (36%), Positives = 310/567 (54%), Gaps = 47/567 (8%)
Query: 1144 ESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNV 1203
+S + + P + GSER + IGDV+GP++N L +L+R+P+GCGEQNMI+FAPN+
Sbjct: 797 QSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNI 856
Query: 1204 FVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVL 1263
++L YL K +QL+ ++ + ++ QGYQR+L Y+R+DGS+SAFG D SGS WL+AFVL
Sbjct: 857 YILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVL 916
Query: 1264 KSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVV 1323
+ F +A +I +D L +W+ Q+++G F GRV++ ++QGG V LTAY+V
Sbjct: 917 RCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIV 976
Query: 1324 VALLETGTASEEERGSTDKARHFLESAAPLAM-DPYSCALTTYALTLLRSPAAPEALRKL 1382
+LL G + ++ HFLES + D Y+ AL TYAL+ + SP A EAL L
Sbjct: 977 TSLL--GYRKYQPNIDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNML 1034
Query: 1383 RSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAA 1442
A G+ W S S SD S S ++E+ AYALL++ L +
Sbjct: 1035 TWRAEQEGGMQFWVSSES---------KLSD--SWQPRSLDIEVAAYALLSHFLQFQTSE 1083
Query: 1443 ALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETF 1502
+P+++WLS+QRN+LGGF+STQDT VAL+AL+E+A L N+ V++ + F
Sbjct: 1084 GIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPVKF 1143
Query: 1503 ELHRTNQKVLQTAAIPSL-PTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQE 1561
+ N+ +LQTA + + PT + +SA G G + Q++V YNV A + + S+Q
Sbjct: 1144 LIDTHNRLLLQTAELAVVQPTAVNISANGFGFAICQLNVVYNVK---ASGSSRRRRSIQN 1200
Query: 1562 PEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYK-VMLEVCTRWLHAGSSNMAV 1620
E A D D A ++ + V L VCT + G S MA+
Sbjct: 1201 QE----------------------AFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMAL 1238
Query: 1621 LEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALREC 1680
+EV LLSGF E+ + +K+ E ++ Y D + + CV A+R
Sbjct: 1239 MEVNLLSGFMVPSEA-----ISLSETVKKVEYDHGKLNLYLDSV-NETQFCVNIPAVRNF 1292
Query: 1681 VVGRTSALPVSVYDYYEPAFEATRFYN 1707
V T VS+ DYYEP +A R YN
Sbjct: 1293 KVSNTQDASVSIVDYYEPRRQAVRSYN 1319
Score = 187 bits (475), Expect = 9e-47
Identities = 203/811 (25%), Positives = 331/811 (40%), Gaps = 154/811 (18%)
Query: 216 DPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPK 275
DP+ + + +W + G+ + +F LS P+LG+W I V++ Y +SF+V +YVLPK
Sbjct: 93 DPKSNLIQQWLSQQSDL-GVISKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPK 151
Query: 276 FELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTT 335
FE+ + P Y GT+ A+YT+GKPV G + +T + ++ + + + +T
Sbjct: 152 FEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGD--VTLTFLPLSFWGKK--KNITKTF 207
Query: 336 KILGSRDFDICVRDM---------IPADVPEHFRGRVSIWAMVT-SVDGSQQVAFDDSTP 385
KI GS +F +M + + G V I VT SV G ++ + ST
Sbjct: 208 KINGSANFSFNDEEMKNVMDSSNGLSEYLDLSSPGPVEILTTVTESVTG---ISRNVSTN 264
Query: 386 VQRQLVD-IRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYT-- 442
V + D I D KP L + V+++ DG+ + +T YT
Sbjct: 265 VFFKQHDYIIEFFDYTTVLKPSLNFTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEY 324
Query: 443 -----------------SEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYL 485
+ V Q G E P + S++ L+ K L K
Sbjct: 325 WSGSNSGNQKMEAVQKINYTVPQSGTFKIEFPILEDSSE---LQLKAYFLGSK------- 374
Query: 486 PSYLSLGSWY-SPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLS 544
S +++ S + SPS+ Y+QL+ ++VG V L Y V +RG +V
Sbjct: 375 -SSMAVHSLFKSPSKTYIQLKTRDENIKVGSPFELVVSGNKRLK-ELSYMVVSRGQLVAV 432
Query: 545 GQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLG 604
G+Q + T L S P
Sbjct: 433 GKQNS----------------------------------------TMFSLTPENSWTPKA 452
Query: 605 RLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAAR-GSCVCV 663
++V+Y+ ++GE ++D L+ V+ F+N++ + +S + +P E V LRI + S V +
Sbjct: 453 CVIVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGI 512
Query: 664 AAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFP 723
AVDKSV L+ + +T V ELE Y+
Sbjct: 513 VAVDKSVNLMNASNDITMENVVHELELYNTG----------------------------- 543
Query: 724 WPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAF-QPHTGSLVAVAPSRH 782
+ G+ +S F E GL V+TD DG E F + + G +V +
Sbjct: 544 YYLGMFMNSFAVFQECGLWVLTDANLTKDYIDGVYDNAEYAERFMEENEGHIVDIHDFSL 603
Query: 783 PPRTEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI-A 841
RK FPETWIW N+ + V VPDSITSWV +S GLG+
Sbjct: 604 GSSPHVRKH--FPETWIWLDTNMGYRIYQ-EFEVTVPDSITSWVATGFVISEDLGLGLTT 660
Query: 842 EPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPG 901
P L+ F+PFF+ LP +IRGE+ + ++++NY+ EV + + +
Sbjct: 661 TPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSN 720
Query: 902 KRHVT---KKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEEN 958
+ + T + + V + + + + LG IT AL+
Sbjct: 721 EINATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALS------------------- 761
Query: 959 HADRRVPIGVDHVRRSVMVEAEGVPRAYTYS 989
P D V + ++V+AEG+ ++Y+ S
Sbjct: 762 ------PTASDAVTQMILVKAEGIEKSYSQS 786
>gi|115529484 CD109 antigen isoform 1 precursor [Homo sapiens]
Length = 1445
Score = 329 bits (844), Expect = 1e-89
Identities = 209/567 (36%), Positives = 310/567 (54%), Gaps = 47/567 (8%)
Query: 1144 ESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNV 1203
+S + + P + GSER + IGDV+GP++N L +L+R+P+GCGEQNMI+FAPN+
Sbjct: 874 QSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNI 933
Query: 1204 FVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVL 1263
++L YL K +QL+ ++ + ++ QGYQR+L Y+R+DGS+SAFG D SGS WL+AFVL
Sbjct: 934 YILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVL 993
Query: 1264 KSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVV 1323
+ F +A +I +D L +W+ Q+++G F GRV++ ++QGG V LTAY+V
Sbjct: 994 RCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIV 1053
Query: 1324 VALLETGTASEEERGSTDKARHFLESAAPLAM-DPYSCALTTYALTLLRSPAAPEALRKL 1382
+LL G + ++ HFLES + D Y+ AL TYAL+ + SP A EAL L
Sbjct: 1054 TSLL--GYRKYQPNIDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNML 1111
Query: 1383 RSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAA 1442
A G+ W S S SD S S ++E+ AYALL++ L +
Sbjct: 1112 TWRAEQEGGMQFWVSSES---------KLSD--SWQPRSLDIEVAAYALLSHFLQFQTSE 1160
Query: 1443 ALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETF 1502
+P+++WLS+QRN+LGGF+STQDT VAL+AL+E+A L N+ V++ + F
Sbjct: 1161 GIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPVKF 1220
Query: 1503 ELHRTNQKVLQTAAIPSL-PTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQE 1561
+ N+ +LQTA + + PT + +SA G G + Q++V YNV A + + S+Q
Sbjct: 1221 LIDTHNRLLLQTAELAVVQPTAVNISANGFGFAICQLNVVYNVK---ASGSSRRRRSIQN 1277
Query: 1562 PEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYK-VMLEVCTRWLHAGSSNMAV 1620
E A D D A ++ + V L VCT + G S MA+
Sbjct: 1278 QE----------------------AFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMAL 1315
Query: 1621 LEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALREC 1680
+EV LLSGF E+ + +K+ E ++ Y D + + CV A+R
Sbjct: 1316 MEVNLLSGFMVPSEA-----ISLSETVKKVEYDHGKLNLYLDSV-NETQFCVNIPAVRNF 1369
Query: 1681 VVGRTSALPVSVYDYYEPAFEATRFYN 1707
V T VS+ DYYEP +A R YN
Sbjct: 1370 KVSNTQDASVSIVDYYEPRRQAVRSYN 1396
Score = 244 bits (624), Expect = 5e-64
Identities = 253/967 (26%), Positives = 412/967 (42%), Gaps = 170/967 (17%)
Query: 72 AAQPQAPG--YLIAAPSVFRAGVEEVISVTIF-NSPREVTVQAQLVAQGE----PVVQSQ 124
AA APG +L+ AP + R G I V + + P +VTV+A+L+ V++++
Sbjct: 18 AALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAE 77
Query: 125 GAILDKGTIK-LKVPTGLRGQA----LLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFI 179
G + +KG+ K L +P+ A L+V GR ++ LF N T ++ + + SVFI
Sbjct: 78 G-VFEKGSFKTLTLPSLPLNSADEIYELRVTGR---TQDEILFSNSTRLSFETKRISVFI 133
Query: 180 QTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMS 239
QTDK +Y+P+ V I T+ + +P L I DP+ + + +W + G+ + +
Sbjct: 134 QTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWLSQQSDL-GVISKT 192
Query: 240 FPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRA 299
F LS P+LG+W I V++ Y +SF+V +YVLPKFE+ + P Y GT+ A
Sbjct: 193 FQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITA 252
Query: 300 RYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDM--------- 350
+YT+GKPV G + +T + ++ + + + +T KI GS +F +M
Sbjct: 253 KYTYGKPVKGD--VTLTFLPLSFWGKK--KNITKTFKINGSANFSFNDEEMKNVMDSSNG 308
Query: 351 IPADVPEHFRGRVSIWAMVT-SVDGSQQVAFDDSTPVQRQLVD-IRYSKDTRKQFKPGLA 408
+ + G V I VT SV G ++ + ST V + D I D KP L
Sbjct: 309 LSEYLDLSSPGPVEILTTVTESVTG---ISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLN 365
Query: 409 YVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYT-------------------SEVVSQR 449
+ V+++ DG+ + +T YT + V Q
Sbjct: 366 FTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQS 425
Query: 450 GLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWY-SPSQCYLQLQPPS 508
G E P + S++ L+ K L K S +++ S + SPS+ Y+QL+
Sbjct: 426 GTFKIEFPILEDSSE---LQLKAYFLGSK--------SSMAVHSLFKSPSKTYIQLKTRD 474
Query: 509 HPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIR 568
++VG V L Y V +RG +V G+Q +
Sbjct: 475 ENIKVGSPFELVVSGNKRLK-ELSYMVVSRGQLVAVGKQNS------------------- 514
Query: 569 LTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVET 628
T L S P ++V+Y+ ++GE ++D L+ V+
Sbjct: 515 ---------------------TMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQL 553
Query: 629 FFENQVSVTYSANETQPGEVVDLRIRAAR-GSCVCVAAVDKSVYLLRSGFRLTPAQVFQE 687
F+N++ + +S + +P E V LRI + S V + AVDKSV L+ + +T V E
Sbjct: 554 VFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHE 613
Query: 688 LEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDR 747
LE Y+ + G+ +S F E GL V+TD
Sbjct: 614 LELYNTG-----------------------------YYLGMFMNSFAVFQECGLWVLTDA 644
Query: 748 VSLNHRQDGGLYTDEAVPAF-QPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNIS 806
DG E F + + G +V + RK FPETWIW N+
Sbjct: 645 NLTKDYIDGVYDNAEYAERFMEENEGHIVDIHDFSLGSSPHVRKH--FPETWIWLDTNMG 702
Query: 807 DPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI-AEPSLLKTFKPFFVDFMLPALIIRG 865
+ V VPDSITSWV +S GLG+ P L+ F+PFF+ LP +IRG
Sbjct: 703 YRIYQ-EFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRG 761
Query: 866 EQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVT---KKMCVAPGEAEPIWVV 922
E+ + ++++NY+ EV + + + + + T + + V + +
Sbjct: 762 EEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFP 821
Query: 923 LSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGV 982
+ + LG IT AL+ P D V + ++V+AEG+
Sbjct: 822 IRPTHLGEIPITVTALS-------------------------PTASDAVTQMILVKAEGI 856
Query: 983 PRAYTYS 989
++Y+ S
Sbjct: 857 EKSYSQS 863
>gi|227430301 CD109 antigen isoform 2 precursor [Homo sapiens]
Length = 1428
Score = 315 bits (808), Expect = 2e-85
Identities = 206/566 (36%), Positives = 303/566 (53%), Gaps = 62/566 (10%)
Query: 1144 ESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNV 1203
+S + + P + GSER + IGDV+GP++N L +L+R+P+GCGEQNMI+FAPN+
Sbjct: 874 QSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNI 933
Query: 1204 FVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVL 1263
++L YL K +QL+ ++ + ++ QGYQR+L Y+R+DGS+SAFG D SGS WL+AFVL
Sbjct: 934 YILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVL 993
Query: 1264 KSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVV 1323
+ F +A +I +D L +W+ Q+++G F GRV++ ++QGG V LTAY+V
Sbjct: 994 RCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIV 1053
Query: 1324 VALLETGTASEEERGSTDKARHFLESAAPLAM-DPYSCALTTYALTLLRSPAAPEALRKL 1382
+LL G + ++ HFLES + D Y+ AL TYAL+ + SP A EAL L
Sbjct: 1054 TSLL--GYRKYQPNIDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNML 1111
Query: 1383 RSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAA 1442
A G+ W S S SD S S ++E+ AYALL++ L +
Sbjct: 1112 TWRAEQEGGMQFWVSSES---------KLSD--SWQPRSLDIEVAAYALLSHFLQFQTSE 1160
Query: 1443 ALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETF 1502
+P+++WLS+QRN+LGGF+STQDT VAL+AL+E+A L ++ TN+ T
Sbjct: 1161 GIPIMRWLSRQRNSLGGFASTQDTTVALKALSEFAAL---------MNTERTNIQVTVTG 1211
Query: 1503 ELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEP 1562
+ V+Q PT + +SA G G + Q++V YNV A + + S+Q
Sbjct: 1212 PSSPSPLAVVQ-------PTAVNISANGFGFAICQLNVVYNVK---ASGSSRRRRSIQNQ 1261
Query: 1563 EAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYK-VMLEVCTRWLHAGSSNMAVL 1621
E A D D A ++ + V L VCT + G S MA++
Sbjct: 1262 E----------------------AFDLDVAVKENKDDLNHVDLNVCTSFSGPGRSGMALM 1299
Query: 1622 EVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECV 1681
EV LLSGF E+ + +K+ E ++ Y D + + CV A+R
Sbjct: 1300 EVNLLSGFMVPSEA-----ISLSETVKKVEYDHGKLNLYLDSV-NETQFCVNIPAVRNFK 1353
Query: 1682 VGRTSALPVSVYDYYEPAFEATRFYN 1707
V T VS+ DYYEP +A R YN
Sbjct: 1354 VSNTQDASVSIVDYYEPRRQAVRSYN 1379
Score = 244 bits (624), Expect = 5e-64
Identities = 253/967 (26%), Positives = 412/967 (42%), Gaps = 170/967 (17%)
Query: 72 AAQPQAPG--YLIAAPSVFRAGVEEVISVTIF-NSPREVTVQAQLVAQGE----PVVQSQ 124
AA APG +L+ AP + R G I V + + P +VTV+A+L+ V++++
Sbjct: 18 AALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAE 77
Query: 125 GAILDKGTIK-LKVPTGLRGQA----LLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFI 179
G + +KG+ K L +P+ A L+V GR ++ LF N T ++ + + SVFI
Sbjct: 78 G-VFEKGSFKTLTLPSLPLNSADEIYELRVTGR---TQDEILFSNSTRLSFETKRISVFI 133
Query: 180 QTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMS 239
QTDK +Y+P+ V I T+ + +P L I DP+ + + +W + G+ + +
Sbjct: 134 QTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWLSQQSDL-GVISKT 192
Query: 240 FPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRA 299
F LS P+LG+W I V++ Y +SF+V +YVLPKFE+ + P Y GT+ A
Sbjct: 193 FQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITA 252
Query: 300 RYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDM--------- 350
+YT+GKPV G + +T + ++ + + + +T KI GS +F +M
Sbjct: 253 KYTYGKPVKGD--VTLTFLPLSFWGKK--KNITKTFKINGSANFSFNDEEMKNVMDSSNG 308
Query: 351 IPADVPEHFRGRVSIWAMVT-SVDGSQQVAFDDSTPVQRQLVD-IRYSKDTRKQFKPGLA 408
+ + G V I VT SV G ++ + ST V + D I D KP L
Sbjct: 309 LSEYLDLSSPGPVEILTTVTESVTG---ISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLN 365
Query: 409 YVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYT-------------------SEVVSQR 449
+ V+++ DG+ + +T YT + V Q
Sbjct: 366 FTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQS 425
Query: 450 GLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWY-SPSQCYLQLQPPS 508
G E P + S++ L+ K L K S +++ S + SPS+ Y+QL+
Sbjct: 426 GTFKIEFPILEDSSE---LQLKAYFLGSK--------SSMAVHSLFKSPSKTYIQLKTRD 474
Query: 509 HPLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIR 568
++VG V L Y V +RG +V G+Q +
Sbjct: 475 ENIKVGSPFELVVSGNKRLK-ELSYMVVSRGQLVAVGKQNS------------------- 514
Query: 569 LTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVET 628
T L S P ++V+Y+ ++GE ++D L+ V+
Sbjct: 515 ---------------------TMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQL 553
Query: 629 FFENQVSVTYSANETQPGEVVDLRIRAAR-GSCVCVAAVDKSVYLLRSGFRLTPAQVFQE 687
F+N++ + +S + +P E V LRI + S V + AVDKSV L+ + +T V E
Sbjct: 554 VFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHE 613
Query: 688 LEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDR 747
LE Y+ + G+ +S F E GL V+TD
Sbjct: 614 LELYNTG-----------------------------YYLGMFMNSFAVFQECGLWVLTDA 644
Query: 748 VSLNHRQDGGLYTDEAVPAF-QPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNIS 806
DG E F + + G +V + RK FPETWIW N+
Sbjct: 645 NLTKDYIDGVYDNAEYAERFMEENEGHIVDIHDFSLGSSPHVRKH--FPETWIWLDTNMG 702
Query: 807 DPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGI-AEPSLLKTFKPFFVDFMLPALIIRG 865
+ V VPDSITSWV +S GLG+ P L+ F+PFF+ LP +IRG
Sbjct: 703 YRIYQ-EFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRG 761
Query: 866 EQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVT---KKMCVAPGEAEPIWVV 922
E+ + ++++NY+ EV + + + + + T + + V + +
Sbjct: 762 EEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFP 821
Query: 923 LSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGV 982
+ + LG IT AL+ P D V + ++V+AEG+
Sbjct: 822 IRPTHLGEIPITVTALS-------------------------PTASDAVTQMILVKAEGI 856
Query: 983 PRAYTYS 989
++Y+ S
Sbjct: 857 EKSYSQS 863
>gi|66932947 alpha-2-macroglobulin precursor [Homo sapiens]
Length = 1474
Score = 313 bits (803), Expect = 8e-85
Identities = 207/589 (35%), Positives = 308/589 (52%), Gaps = 62/589 (10%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
SE +L +P + S RA+ S++GD++G + + NLL++P+GCGEQNM+ FAPN++VL
Sbjct: 928 SEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVL 987
Query: 1207 KYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDA--SGSMWLTAFVLK 1264
YL +TQQL+PE++ + YL GYQRQL YK DGSYS FGER G+ WLTAFVLK
Sbjct: 988 DYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLK 1047
Query: 1265 SFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVV 1324
+FAQAR++IF+D + A W+ Q+Q+ +G F + G +LN I+GG+ V L+AY+ +
Sbjct: 1048 TFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITI 1107
Query: 1325 ALLETGTASEEERGSTDKARHFLESAAPLAMD------PYSCALTTYALTLL-RSPAAPE 1377
ALLE A LESA A + Y+ AL YA L E
Sbjct: 1108 ALLEIPLTVTHP--VVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKE 1165
Query: 1378 ALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLL 1437
L+ L A+ +D HW G F SAEVEMT+Y LL Y
Sbjct: 1166 VLKSLNEEAVKKDNSVHWERPQKPKAPVGHF------YEPQAPSAEVEMTSYVLLAYLTA 1219
Query: 1438 ------GDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYA-GGINLTVS 1490
D+ +A +VKW+++Q+NA GGFSSTQDT VAL AL++Y ++ G V+
Sbjct: 1220 QPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVT 1279
Query: 1491 LASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNV-PDPVA 1549
+ S+ + F++ N+ +LQ ++P LP + G+GC +Q + YN+ P+
Sbjct: 1280 IQSSG-TFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPE--- 1335
Query: 1550 KPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTR 1609
K F + +Q P D+P A H +++ L V
Sbjct: 1336 KEEFPFALGVQT----------------------LPQTCDEPKA---HTSFQISLSVSYT 1370
Query: 1610 WLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCL 1669
+ +SNMA+++V ++SGF +++ L H + R EV+ VL Y D++ ++ L
Sbjct: 1371 GSRS-ASNMAIVDVKMVSGFIPLKPTVKMLERSNH--VSRTEVSSNHVLIYLDKVSNQTL 1427
Query: 1670 TCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLAREL 1718
+ + F L++ V V VYDYYE A YN +P +++L
Sbjct: 1428 S-LFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYN----APCSKDL 1471
Score = 247 bits (631), Expect = 7e-65
Identities = 243/988 (24%), Positives = 416/988 (42%), Gaps = 114/988 (11%)
Query: 52 LLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQA 111
LL P L LLLL+L D + +PQ Y++ PS+ E V + VTV A
Sbjct: 6 LLHPSLVLLLLVLLPTDASVSGKPQ---YMVLVPSLLHTETTEKGCVLLSYLNETVTVSA 62
Query: 112 QLVAQGEPVVQSQGAILDKGT-------IKLKVPTGLRGQAL--LKVWGRGWQAEEGPLF 162
L E V ++ D + VP + + L V +G E F
Sbjct: 63 SL----ESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQE----F 114
Query: 163 HNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLE-AYILDPRGSR 221
+T+V V + VF+QTDK +Y+P V + ++ N P+NE + YI DP+G+R
Sbjct: 115 KKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNR 174
Query: 222 MIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQ-GHAYNKSFEVQKYVLPKFELLI 280
+ +W+ + G+ SFPLS +P G + + V+ + G F V+++VLPKFE+ +
Sbjct: 175 IAQWQSFQ-LEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQV 233
Query: 281 DPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGS 340
P+ I L+ +V YT+GKPV G + +++ K G
Sbjct: 234 TVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQ 293
Query: 341 RDFDICVRDMIPADV----PEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYS 396
+ C + V + + ++ A + ++ S+ + R + + +
Sbjct: 294 LNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFV 353
Query: 397 KDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEI 456
K F+ G+ + G+V L G P + I+ + N Y++ + GLV F I
Sbjct: 354 K-VDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGN---EANYYSNATTDEHGLVQFSI 409
Query: 457 PSIPTSAQHVWLETKVMALNGKP------VGAQYLPSYLSLGSWYSPSQCYLQLQPPSHP 510
+ T+ L +V + P V ++ ++ + +SPS+ ++ L+P SH
Sbjct: 410 NT--TNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHE 467
Query: 511 LQVGE----EAYFSVKSTCPC---NFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPAL 563
L G +A++ + + YY + A+G IV +G Q+ K
Sbjct: 468 LPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMK------ 521
Query: 564 EKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQ 623
H S+ + V + P+ RLL++ V G+ + DS +
Sbjct: 522 ------GHF------------------SISIPVKSDIAPVARLLIYAVLPTGDVIGDSAK 557
Query: 624 FAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQ 683
+ VE N+V +++S +++ P LR+ AA S + AVD+SV L++ L+ +
Sbjct: 558 YDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASS 617
Query: 684 VFQELEDYDVS----------DSFGVSRED---GPFWWAGLTAQRRRRSSVFPWPWGITK 730
V+ L + D++ D ++R + + +++ + F G+
Sbjct: 618 VYNLLPEKDLTGFPGPLNDQDDEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKA 677
Query: 731 DSGFAFTETGLVVMTDRVSLNHRQDG---GLYTDEAVPAFQPHTGSLVAVAPSRHPPRTE 787
+ + + + + H +G G Y + + G A P TE
Sbjct: 678 FTNSKIRKPKMCPQLQQYEM-HGPEGLRVGFYESDVM-------GRGHARLVHVEEPHTE 729
Query: 788 KRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLK 847
R +FPETWIW L + + +G + V VPD+IT W A LS GLGI+ + L+
Sbjct: 730 -TVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLR 787
Query: 848 TFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTK 907
F+PFFV+ +P +IRGE + +V NY+ C V ++L F+ P ++
Sbjct: 788 AFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPA--FLAVPVEKEQAP 845
Query: 908 KMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIG 967
A G W V S LG N T A A C ++ P R+
Sbjct: 846 HCICANGRQTVSWAVTPKS-LGNVNFTVSAEALESQELC----GTEVPSVPEHGRK---- 896
Query: 968 VDHVRRSVMVEAEGVPRAYTYSAFFCPS 995
D V + ++VE EG+ + T+++ CPS
Sbjct: 897 -DTVIKPLLVEPEGLEKETTFNSLLCPS 923
>gi|162809334 pregnancy-zone protein [Homo sapiens]
Length = 1482
Score = 308 bits (790), Expect = 3e-83
Identities = 192/566 (33%), Positives = 289/566 (51%), Gaps = 54/566 (9%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
SE +L +P + S RA+ S++GD++G + ++ NLL++P+GCGEQNM+ FAPN++VL
Sbjct: 934 SEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVL 993
Query: 1207 KYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDA--SGSMWLTAFVLK 1264
YL +TQQL+ E++ + YL+ GYQRQL YK QDGSYS FGER G+ WLTAFVLK
Sbjct: 994 NYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLK 1053
Query: 1265 SFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVV 1324
+FAQARS+IF+D + + +W+ Q Q+ +G F + G +LN I+GG+ L+AYV +
Sbjct: 1054 TFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTI 1113
Query: 1325 ALLETGTASEEERGSTDKARHFLESAAPLAMD------PYSCALTTYALTLL-RSPAAPE 1377
ALLE A LESA +A + Y+ AL YA +LL + E
Sbjct: 1114 ALLEIPLPVTNP--IVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNRE 1171
Query: 1378 ALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTYTLL 1437
L L A+ D + HW G SAEVEMT+Y LL Y
Sbjct: 1172 ILNSLDKEAVKEDNLVHWERPQRPKAPVGHL------YQTQAPSAEVEMTSYVLLAYLTA 1225
Query: 1438 ------GDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSL 1491
GD+ +A +VKW+ +Q+NA GGFSSTQDT VAL AL+ Y ++
Sbjct: 1226 QPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVT 1285
Query: 1492 ASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKP 1551
+ + F++ N +LQ ++P LP ++ G+ C +Q + YN+
Sbjct: 1286 VQDSQTFSTNFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDS 1345
Query: 1552 AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWL 1611
F L V G + H +++ L +
Sbjct: 1346 PFALKVQTVPQTCDGH---------------------------KAHTSFQISLTISYTG- 1377
Query: 1612 HAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTC 1671
+ +SNM +++V ++SGF +++ +L++ + R EV+ VL Y +++ ++ L+
Sbjct: 1378 NRPASNMVIVDVKMVSGFIPLKPTVK--MLERSSSVSRTEVSNNHVLIYVEQVTNQTLS- 1434
Query: 1672 VRFRALRECVVGRTSALPVSVYDYYE 1697
F L++ VG V VYDYYE
Sbjct: 1435 FSFMVLQDIPVGDLKPAIVKVYDYYE 1460
Score = 229 bits (584), Expect = 2e-59
Identities = 240/992 (24%), Positives = 419/992 (42%), Gaps = 116/992 (11%)
Query: 52 LLWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQA 111
LL L LLL+LLSA D + +PQ Y++ PS+ + V + + VTV A
Sbjct: 6 LLHLCLVLLLILLSASDS-NSTEPQ---YMVLVPSLLHTEAPKKGCVLLSHLNETVTVSA 61
Query: 112 QLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPL--FHNQTSVT 169
L + E + +K T R A +V Q + GP F + +V
Sbjct: 62 SLESGRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIK-GPTQDFRKRNTVL 120
Query: 170 VDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEA-YILDPRGSRMIEWRHL 228
V + VF+QTDKP+Y+P V + +V N RP NE + Y+ +PR +R+ +W+ L
Sbjct: 121 VLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSL 180
Query: 229 KPFCCGITNMSFPLSDQPVLGEWFIFVEMQ-GHAYNKSFEVQKYVLPKFELLIDPPRYIQ 287
K GI +SFPLS +P+ G + + V+ + G F V+++VLPKFE+ + P+ I
Sbjct: 181 K-LEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIIS 239
Query: 288 DLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICV 347
+D TV YT+GKPV G +++ + + ++ L S C+
Sbjct: 240 IMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNG---CI 296
Query: 348 RDMIPADVPE----HFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQF 403
+ + + F ++ + A + +V + + + + +++ K F
Sbjct: 297 TQQVHTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRISEITNIVSKLKFVK-VDSHF 355
Query: 404 KPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFEIPSIPTSA 463
+ G+ + +V L G P I N Y++ +++GL F I + S
Sbjct: 356 RQGIPFFAQVLLVDGKGVPIPNKLFFISVN---DANYYSNATTNEQGLAQFSINTTSISV 412
Query: 464 QHVWLETKV----MALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYF 519
+++ + + V + + + +S S Y+ L+P + L G
Sbjct: 413 NKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETI 472
Query: 520 SVKSTCP-------CNFTLYYEVAARGNIVLSGQQPAHT--TQQRSKRAAPALEKPIRLT 570
+ T + +Y + A+G IV SG HT + + + AL P+
Sbjct: 473 TAHYTLNRQAMGELSELSFHYLIMAKGVIVRSG---THTLPVESGDMKGSFALSFPV--- 526
Query: 571 HLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFF 630
E DV P+ R+ +F + +GE V DS +F +E
Sbjct: 527 -------------ESDV-------------APIARMFIFAILPDGEVVGDSEKFEIENCL 560
Query: 631 ENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELED 690
N+V +++S ++ P L++ AA S + AVD+SV L++ L+ + V+ L
Sbjct: 561 ANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTV 620
Query: 691 YDVS---DSFGVSRED-----GPFWWAGLTAQRRRRSSVFPWPWGITKDSGFAFTE-TGL 741
D++ D+ E+ PF+ + P + ++F + GL
Sbjct: 621 KDLTNFPDNVDQQEEEQGHCPRPFF---------IHNGAIYVPLSSNEADIYSFLKGMGL 671
Query: 742 VVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPR---------------- 785
V T+ + + + A Q + G+ + V + P+
Sbjct: 672 KVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSG 731
Query: 786 -TEKRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPS 844
+ R++FPETWIW + ++ SG + V VPD+IT W A LS GLGI+ +
Sbjct: 732 PVPETVRSYFPETWIWELVAVNS-SGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTA 790
Query: 845 LLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSV-PKGIQFVGHPGKR 903
L+ F+PFFV+ +P +IRGE + +V NY+ C V ++L P + G+
Sbjct: 791 SLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGE- 849
Query: 904 HVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRR 963
+ C+ E + + ++ LG N + A A C ++ E R+
Sbjct: 850 ---ESYCICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELC----GNEVVEVPEIKRK 902
Query: 964 VPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPS 995
D V ++++VEAEG+ + T+S+ C S
Sbjct: 903 -----DTVIKTLLVEAEGIEQEKTFSSMTCAS 929
>gi|74271845 alpha-2-macroglobulin-like 1 [Homo sapiens]
Length = 1454
Score = 302 bits (773), Expect = 2e-81
Identities = 199/568 (35%), Positives = 301/568 (52%), Gaps = 50/568 (8%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
SE+ +L +P +P S +A +++GD+MG L +L+ L+++P GCGEQNM+ FAP ++VL
Sbjct: 926 SESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNMVLFAPIIYVL 985
Query: 1207 KYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
+YL+K L+ E+ +L GYQ++L YK +GSYSAFGERD +G+ WLTAFV K F
Sbjct: 986 QYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNTWLTAFVTKCF 1045
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVAL 1326
QA+ FIF+DP+ + A W+ Q G + VG +L+ ++GG+ V LTAYV AL
Sbjct: 1046 GQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAAL 1105
Query: 1327 LETGTASEEERGSTDKARHFLESAAPLAMDPYSCALTTYALTLL-RSPAAPEALRKLRSL 1385
LE G ++ S + L+++A + Y+ AL Y +L L++L
Sbjct: 1106 LEMGKDVDDPMVS--QGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQ 1163
Query: 1386 AIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTY-----TLLGDV 1440
AI+ +WS K T S + S+ + +VE+TAYALL ++
Sbjct: 1164 AIISGESIYWS-------QKPTPSSNASPWSEP-AAVDVELTAYALLAQLTKPSLTQKEI 1215
Query: 1441 AAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQE 1500
A A +V WL++QRNA GGFSSTQDT VALQALA+YA +Y + + + ST ++Q
Sbjct: 1216 AKATSIVAWLAKQRNAYGGFSSTQDTVVALQALAKYATTAYMPSEEINLVVKSTE-NFQR 1274
Query: 1501 TFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQ 1560
TF + N+ V Q +P++P + A G GC +Q + YN+ P F L S++
Sbjct: 1275 TFNIQSVNRLVFQQDTLPNVPGMYTLEASGQGCVYVQTVLRYNILPPTNMKTFSL--SVE 1332
Query: 1561 EPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLHA-GSSNMA 1619
+A+ P P S + L + T ++ + SSNMA
Sbjct: 1333 IGKARCEQPTSPRS---------------------------LTLTIHTSYVGSRSSSNMA 1365
Query: 1620 VLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRE 1679
++EV +LSGF + +E QLLL + + +K+ E + Y DE+ T F +
Sbjct: 1366 IVEVKMLSGF-SPMEGTNQLLLQQPL-VKKVEFGTDTLNIYLDELIKNTQT-YTFTISQS 1422
Query: 1680 CVVGRTSALPVSVYDYYEPAFEATRFYN 1707
+V + VYDYY P +AT Y+
Sbjct: 1423 VLVTNLKPATIKVYDYYLPDEQATIQYS 1450
Score = 249 bits (635), Expect = 2e-65
Identities = 246/991 (24%), Positives = 423/991 (42%), Gaps = 112/991 (11%)
Query: 53 LWPLLPLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQ 112
+W L L +L LS A + P YL+ P+ R V V + SP V+
Sbjct: 1 MWAQLLLGMLALSP-----AIAEELPNYLVTLPA--RLNFPSVQKVCLDLSPGYSDVKFT 53
Query: 113 LVAQGEPVVQSQGAILDKGTIKLK--------VPT---GLRGQALLKVWGRGWQAEEGPL 161
+ + + Q +L+ +K + VP G A ++V G G
Sbjct: 54 VTLETKDKTQK---LLEYSGLKKRHLHCISFLVPPPAGGTEEVATIRVSGVGNNIS---- 106
Query: 162 FHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYIL-DPRGS 220
F + V + +G F+QTDKP+Y P +V I T+ N PVN+K L DP +
Sbjct: 107 FEEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTMDSNFVPVNDKYSMVELQDPNSN 166
Query: 221 RMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQKYVLPKFELLI 280
R+ +W + P GI ++SF L+ + +LG + + V +G + +F V++YVLPKF++ +
Sbjct: 167 RIAQWLEVVPEQ-GIVDLSFQLAPEAMLGTYTVAVA-EGKTFG-TFSVEEYVLPKFKVEV 223
Query: 281 DPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVL--RTTKIL 338
P+ + + + RYT+GKP+ GA+ +++ Y+ EV R L + +
Sbjct: 224 VEPKELSTVQESFLVKICCRYTYGKPMLGAVQVSVCQKANTYWYREVEREQLPDKCRNLS 283
Query: 339 GSRDFDICVR---DMIPADVPEH-FRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIR 394
G D C DM D+ + + +++I A V + + + Q+ +
Sbjct: 284 GQTDKTGCFSAPVDMATFDLIGYAYSHQINIVATVVEEGTGVEANATQNIYISPQMGSMT 343
Query: 395 YSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGF 454
+ +DT + P + GK+ + D S + V + T + V GL F
Sbjct: 344 F-EDTSNFYHPNFPFSGKIRVRGHDDSFLKNHLVFLVIYGT-NGTFNQTLVTDNNGLAPF 401
Query: 455 EIPSIPTSAQHVWLETKV----MALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHP 510
+ + + V LE K + N + V Y +YL L +YS ++ +L + + P
Sbjct: 402 TLETSGWNGTDVSLEGKFQMEDLVYNPEQVPRYYQNAYLHLRPFYSTTRSFLGIHRLNGP 461
Query: 511 LQVGE------EAYFSVKSTCP-CNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPAL 563
L+ G+ + Y P + Y + +G++V+ GQ+ ++ ++ K +
Sbjct: 462 LKCGQPQEVLVDYYIDPADASPDQEISFSYYLIGKGSLVMEGQKHLNSKKKGLKAS---- 517
Query: 564 EKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQ 623
SL L T + P L+++ + +G VAD +Q
Sbjct: 518 --------------------------FSLSLTFTSRLAPDPSLVIYAIFPSGGVVADKIQ 551
Query: 624 FAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQ 683
F+VE F+NQVS+ +S ++ PG V+L+++AA GS + AVD+SV LLR L+
Sbjct: 552 FSVEMCFDNQVSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLLRPDRELSNRS 611
Query: 684 VF-----------QELEDYDVSDSFGVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDS 732
V+ ++ +YD G P +RS ++ + D
Sbjct: 612 VYGMFPFWYGHYPYQVAEYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEGTDL 671
Query: 733 GFAFTETGLVVMTDR-----VSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTE 787
F + GL ++++ V +HR A+ A H + + P +
Sbjct: 672 FSFFRDVGLKILSNAKIKKPVDCSHRSP---EYSTAMGAGGGHPEAFESSTPLHQ--AED 726
Query: 788 KRKRTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLK 847
+ R +FPETW+W I + SG+ + V VPD+IT W + S S+G G++ L
Sbjct: 727 SQVRQYFPETWLWDLFPIGN-SGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVGLT 785
Query: 848 TFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTK 907
FKPFFVD LP ++RGE ++ +++NY+ C V L+ Q +
Sbjct: 786 AFKPFFVDLTLPYSVVRGESFRLTATIFNYLKDCIRVQTDLAKSHEYQLESWADSQ---T 842
Query: 908 KMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIG 967
C+ EA+ ++ LG N T C G+ P++ +D +
Sbjct: 843 SSCLCADEAKTHHWNITAVKLGHINFTISTKILDSNEPC-GGQKGFVPQKGRSDTLI--- 898
Query: 968 VDHVRRSVMVEAEGVPRAYTYSAFFCPSERV 998
+ V+V+ EGV T+S+ CP +V
Sbjct: 899 -----KPVLVKPEGVLVEKTHSSLLCPKGKV 924
>gi|178557739 complement component 4B preproprotein [Homo sapiens]
Length = 1744
Score = 236 bits (602), Expect = 2e-61
Identities = 206/634 (32%), Positives = 297/634 (46%), Gaps = 69/634 (10%)
Query: 1154 VPHGAIPGSERATASIIGDVMGP----TLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYL 1209
+P G R TAS D +G + + +LLRLP GCGEQ MI+ AP + +YL
Sbjct: 969 IPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYL 1028
Query: 1210 QKTQQ---LSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
KT+Q L PE + D + +GY R +++ DGSY+A+ R +S WLTAFVLK
Sbjct: 1029 DKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRGSS--TWLTAFVLKVL 1086
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHG---TVPLTAYVV 1323
+ A+ + P +L +W++ QQQADGSF + V+++ +QGG+ G TV LTA+V
Sbjct: 1087 SLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDLSPVIHRSMQGGLVGNDETVALTAFVT 1146
Query: 1324 VALLETGTASEEERG----------STDKARHFL-ESAAPLAMDPYSCALTTYALTLLRS 1372
+A L G A ++ G S KA FL E A+ + ++ A+T YALTL ++
Sbjct: 1147 IA-LHHGLAVFQDEGAEPLKQRVEASISKASSFLGEKASAGLLGAHAAAITAYALTLTKA 1205
Query: 1373 PAAPEALRKLRSLAIMRD-------GVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVE 1425
PA + +A+ ++ G S SN+ + SD + Q+ + +E
Sbjct: 1206 PADLRGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAP-RNPSDPMPQA-PALWIE 1263
Query: 1426 MTAYALLTYTL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYA-- 1482
TAYALL L G A WL++Q + GGF STQDT +AL AL+ Y I S+
Sbjct: 1264 TTAYALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTE 1323
Query: 1483 -GGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVT 1541
G+N+T+S N +L+ + L+ SL + + V G+ +++ T
Sbjct: 1324 ERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRT 1383
Query: 1542 YNVPDPVAKPAFQLLVSLQEPEAQGRPP-PMPASA-AEGSRGDWPPADDDDPAADQ---- 1595
YNV D L + E +G M A+ E D PA DD A Q
Sbjct: 1384 YNVLDMKNTTCQDLQI---EVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTP 1440
Query: 1596 -------------------HHQEYKVMLEVCTRWLH--AGSSNMAVLEVPLLSGFRADIE 1634
QE +V VC W + G S MA+ +V LLSGF A
Sbjct: 1441 LQLFEGRRNRRRREAPKVVEEQESRVHYTVCI-WRNGKVGLSGMAIADVTLLSGFHALRA 1499
Query: 1635 SLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYD 1694
LE+L + +E G VL YFD +P+ CV F A++E VG ++YD
Sbjct: 1500 DLEKLTSLSDRYVSHFETEGPHVLLYFDSVPT-SRECVGFEAVQEVPVGLVQPASATLYD 1558
Query: 1695 YYEPAFEATRFYNVSTHSPLARELCAGPACNEVE 1728
YY P + FY + S L LC+ C E
Sbjct: 1559 YYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAE 1592
Score = 93.2 bits (230), Expect = 2e-18
Identities = 152/711 (21%), Positives = 274/711 (38%), Gaps = 128/711 (18%)
Query: 76 QAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQG--------EPVVQ-SQGA 126
Q P L+ +PSV GV + V + + PR V+ + + P V + +
Sbjct: 19 QKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSS 78
Query: 127 ILDKGTIKLKVPTG----------LRGQALLKVWGRGWQAEEGPLFHNQTSVTV--DGRG 174
D + L+VP LRG + V W + N + + R
Sbjct: 79 ERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRR 138
Query: 175 ASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCG 234
+F+QTD+P+Y P RV +F + +RP + + + + G R+ + P
Sbjct: 139 GHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHGLRVRKKEVYMP--SS 196
Query: 235 ITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS---FEVQKYVLPKFELLIDP--------P 283
I F + D G W I + S FEV+KYVLP FE+ I P P
Sbjct: 197 IFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVP 256
Query: 284 RYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLR----TTKI-- 337
++ ++ ++ARY +GKPV G + G + + R TK+
Sbjct: 257 GHLDEMQL----DIQARYIYGKPVQGVAYVRF-----GLLDEDGKKTFFRGLESQTKLVN 307
Query: 338 ------LGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLV 391
L +F + + + + + R+ + A + G + +++ V
Sbjct: 308 GQSHISLSKAEFQDAL-EKLNMGITDLQGLRLYVAAAIIESPGGE---MEEAELTSWYFV 363
Query: 392 DIRYSKD---TRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQ 448
+S D T++ PG ++ + + GSPA G+ V++ A ++ ++ + + Q
Sbjct: 364 SSPFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDI-Q 422
Query: 449 RGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQ-PP 507
+ G SIP E ++ G P A + L++ + S +L ++ P
Sbjct: 423 QNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPA---IARLTVAAPPSGGPGFLSIERPD 479
Query: 508 SHPLQVGEEAYFSVKST-CPCNFT-LYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEK 565
S P +VG+ ++++ F+ YY + +RG IV ++P T
Sbjct: 480 SRPPRVGDTLNLNLRAVGSGATFSHYYYMILSRGQIVFMNREPKRT-------------- 525
Query: 566 PIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFA 625
+TS+ + V + P + FY VA+SL+
Sbjct: 526 -----------------------LTSVSVFVDHHLAPSFYFVAFYY-HGDHPVANSLRVD 561
Query: 626 VET-FFENQVSVTY-SANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLL--RSGFRLTP 681
V+ E ++ ++ A + + GE V L + + V + A+D ++Y +S L
Sbjct: 562 VQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNM 621
Query: 682 AQVFQELEDYD-------------VSDSFGVSREDGPFWWAGLTAQRRRRS 719
+VF+ + YD V + G++ DG W T R+R S
Sbjct: 622 GKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQW----TLSRKRLS 668
Score = 70.9 bits (172), Expect = 1e-11
Identities = 44/151 (29%), Positives = 77/151 (50%), Gaps = 8/151 (5%)
Query: 791 RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFK 850
R+FFPE W+W + L++ +PDS+T+W ++LS ++GL +A P L+ F+
Sbjct: 775 RSFFPENWLWRVETVDRFQ---ILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFR 831
Query: 851 PFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMC 910
F + LP + R EQ+++ +YNY+ V + +S +G+ G G + +++
Sbjct: 832 EFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGGG---LAQQVL 888
Query: 911 VAPGEAEPIWVVLSFSDLGLNNITAKALAYG 941
V G A P V S ++ K +A G
Sbjct: 889 VPAGSARP--VAFSVVPTAATAVSLKVVARG 917
>gi|239740684 PREDICTED: similar to C4A protein isoform 1 [Homo
sapiens]
Length = 1744
Score = 235 bits (600), Expect = 3e-61
Identities = 209/634 (32%), Positives = 296/634 (46%), Gaps = 69/634 (10%)
Query: 1154 VPHGAIPGSERATASIIGDVMGP----TLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYL 1209
+P G R TAS D +G + + +LLRLP GCGEQ MI+ AP + +YL
Sbjct: 969 IPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYL 1028
Query: 1210 QKTQQ---LSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
KT+Q L PE + D + +GY R +++ DGSY+A+ RD+S WLTAFVLK
Sbjct: 1029 DKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSS--TWLTAFVLKVL 1086
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHG---TVPLTAYVV 1323
+ A+ + P +L +W++ QQQADGSF VL++ +QGG+ G TV LTA+V
Sbjct: 1087 SLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVT 1146
Query: 1324 VALLETGTASEEERG----------STDKARHFL-ESAAPLAMDPYSCALTTYALTLLRS 1372
+A L G A ++ G S KA FL E A+ + ++ A+T YALTL ++
Sbjct: 1147 IA-LHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKA 1205
Query: 1373 PA--APEALRKLRSLAIMRDGVTHW-----SLSNSWDVDKGTFLSFSDRVSQSVVSAEVE 1425
P A L ++A +W S SN+ + SD + Q+ + +E
Sbjct: 1206 PVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAP-RNPSDPMPQA-PALWIE 1263
Query: 1426 MTAYALLTYTL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYA-- 1482
TAYALL L G A WL++Q + GGF STQDT +AL AL+ Y I S+
Sbjct: 1264 TTAYALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTE 1323
Query: 1483 -GGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVT 1541
G+N+T+S N +L+ + L+ SL + + V G+ +++ T
Sbjct: 1324 ERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRT 1383
Query: 1542 YNVPDPVAKPAFQLLVSLQEPEAQGRPP-PMPASA-AEGSRGDWPPADDDDPAADQ---- 1595
YNV D L + E +G M A+ E D PA DD A Q
Sbjct: 1384 YNVLDMKNTTCQDLQI---EVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTP 1440
Query: 1596 -------------------HHQEYKVMLEVCTRWLH--AGSSNMAVLEVPLLSGFRADIE 1634
QE +V VC W + G S MA+ +V LLSGF A
Sbjct: 1441 LQLFEGRRNRRRREAPKVVEEQESRVHYTVCI-WRNGKVGLSGMAIADVTLLSGFHALRA 1499
Query: 1635 SLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYD 1694
LE+L + +E G VL YFD +P+ CV F A++E VG ++YD
Sbjct: 1500 DLEKLTSLSDRYVSHFETEGPHVLLYFDSVPT-SRECVGFEAVQEVPVGLVQPASATLYD 1558
Query: 1695 YYEPAFEATRFYNVSTHSPLARELCAGPACNEVE 1728
YY P + FY + S L LC+ C E
Sbjct: 1559 YYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAE 1592
Score = 93.6 bits (231), Expect = 2e-18
Identities = 152/711 (21%), Positives = 274/711 (38%), Gaps = 128/711 (18%)
Query: 76 QAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQG--------EPVVQ-SQGA 126
Q P L+ +PSV GV + V + + PR V+ + + P V + +
Sbjct: 19 QKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSS 78
Query: 127 ILDKGTIKLKVPTG----------LRGQALLKVWGRGWQAEEGPLFHNQTSVTV--DGRG 174
D + L+VP LRG + V W + N + + R
Sbjct: 79 ERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRR 138
Query: 175 ASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCG 234
+F+QTD+P+Y P RV +F + +RP + + + + G R+ + P
Sbjct: 139 GHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHGLRVRKKEVYMP--SS 196
Query: 235 ITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS---FEVQKYVLPKFELLIDP--------P 283
I F + D G W I + S FEV+KYVLP FE+ I P P
Sbjct: 197 IFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVP 256
Query: 284 RYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLR----TTKI-- 337
++ ++ ++ARY +GKPV G + G + + R TK+
Sbjct: 257 GHLDEMQL----DIQARYIYGKPVQGVAYVRF-----GLLDEDGKKTFFRGLESQTKLVN 307
Query: 338 ------LGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLV 391
L +F + + + + + R+ + A + G + +++ V
Sbjct: 308 GQSHISLSKAEFQDAL-EKLNMGITDLQGLRLYVAAAIIEYPGGE---MEEAELTSWYFV 363
Query: 392 DIRYSKD---TRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQ 448
+S D T++ PG ++ + + GSPA G+ V++ A ++ ++ + + Q
Sbjct: 364 SSPFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDI-Q 422
Query: 449 RGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQ-PP 507
+ G SIP E ++ G P A + L++ + S +L ++ P
Sbjct: 423 QNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPA---IARLTVAAPPSGGPGFLSIEWPD 479
Query: 508 SHPLQVGEEAYFSVKST-CPCNFT-LYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEK 565
S P +VG+ ++++ F+ YY + +RG IV ++P T
Sbjct: 480 SRPPRVGDTLNLNLRAVGSGATFSHYYYMILSRGQIVFMNREPKRT-------------- 525
Query: 566 PIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFA 625
+TS+ + V + P + FY VA+SL+
Sbjct: 526 -----------------------LTSVSVFVDHHLAPSFYFVAFYY-HGDHPVANSLRVD 561
Query: 626 VET-FFENQVSVTY-SANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLL--RSGFRLTP 681
V+ E ++ ++ A + + GE V L + + V + A+D ++Y +S L
Sbjct: 562 VQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNM 621
Query: 682 AQVFQELEDYD-------------VSDSFGVSREDGPFWWAGLTAQRRRRS 719
+VF+ + YD V + G++ DG W T R+R S
Sbjct: 622 GKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQW----TLSRKRLS 668
Score = 70.5 bits (171), Expect = 2e-11
Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 6/129 (4%)
Query: 791 RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFK 850
R+FFPE W+W + L++ +PDS+T+W ++LS ++GL +A P L+ F+
Sbjct: 775 RSFFPENWLWRVETVDRFQ---ILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFR 831
Query: 851 PFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMC 910
F + LP + R EQ+++ +YNY+ V + +S +G+ G G + +++
Sbjct: 832 EFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGGG---LAQQVL 888
Query: 911 VAPGEAEPI 919
V G A P+
Sbjct: 889 VPAGSARPV 897
>gi|67190748 complement component 4A preproprotein [Homo sapiens]
Length = 1744
Score = 234 bits (598), Expect = 5e-61
Identities = 209/634 (32%), Positives = 296/634 (46%), Gaps = 69/634 (10%)
Query: 1154 VPHGAIPGSERATASIIGDVMGP----TLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYL 1209
+P G R TAS D +G + + +LLRLP GCGEQ MI+ AP + +YL
Sbjct: 969 IPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYL 1028
Query: 1210 QKTQQ---LSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
KT+Q L PE + D + +GY R +++ DGSY+A+ RD+S WLTAFVLK
Sbjct: 1029 DKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSS--TWLTAFVLKVL 1086
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHG---TVPLTAYVV 1323
+ A+ + P +L +W++ QQQADGSF VL++ +QGG+ G TV LTA+V
Sbjct: 1087 SLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVT 1146
Query: 1324 VALLETGTASEEERG----------STDKARHFL-ESAAPLAMDPYSCALTTYALTLLRS 1372
+A L G A ++ G S KA FL E A+ + ++ A+T YALTL ++
Sbjct: 1147 IA-LHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKA 1205
Query: 1373 PA--APEALRKLRSLAIMRDGVTHW-----SLSNSWDVDKGTFLSFSDRVSQSVVSAEVE 1425
P A L ++A +W S SN+ + SD + Q+ + +E
Sbjct: 1206 PVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAP-RNPSDPMPQA-PALWIE 1263
Query: 1426 MTAYALLTYTL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYA-- 1482
TAYALL L G A WL++Q + GGF STQDT +AL AL+ Y I S+
Sbjct: 1264 TTAYALLHLLLHEGKAEMADQASAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTE 1323
Query: 1483 -GGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVT 1541
G+N+T+S N +L+ + L+ SL + + V G+ +++ T
Sbjct: 1324 ERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRT 1383
Query: 1542 YNVPDPVAKPAFQLLVSLQEPEAQGRPP-PMPASA-AEGSRGDWPPADDDDPAADQ---- 1595
YNV D L + E +G M A+ E D PA DD A Q
Sbjct: 1384 YNVLDMKNTTCQDLQI---EVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQPVTP 1440
Query: 1596 -------------------HHQEYKVMLEVCTRWLH--AGSSNMAVLEVPLLSGFRADIE 1634
QE +V VC W + G S MA+ +V LLSGF A
Sbjct: 1441 LQLFEGRRNRRRREAPKVVEEQESRVHYTVCI-WRNGKVGLSGMAIADVTLLSGFHALRA 1499
Query: 1635 SLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYD 1694
LE+L + +E G VL YFD +P+ CV F A++E VG ++YD
Sbjct: 1500 DLEKLTSLSDRYVSHFETEGPHVLLYFDSVPT-SRECVGFEAVQEVPVGLVQPASATLYD 1558
Query: 1695 YYEPAFEATRFYNVSTHSPLARELCAGPACNEVE 1728
YY P + FY + S L LC+ C E
Sbjct: 1559 YYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAE 1592
Score = 93.2 bits (230), Expect = 2e-18
Identities = 152/711 (21%), Positives = 274/711 (38%), Gaps = 128/711 (18%)
Query: 76 QAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQG--------EPVVQ-SQGA 126
Q P L+ +PSV GV + V + + PR V+ + + P V + +
Sbjct: 19 QKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSS 78
Query: 127 ILDKGTIKLKVPTG----------LRGQALLKVWGRGWQAEEGPLFHNQTSVTV--DGRG 174
D + L+VP LRG + V W + N + + R
Sbjct: 79 ERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRR 138
Query: 175 ASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCG 234
+F+QTD+P+Y P RV +F + +RP + + + + G R+ + P
Sbjct: 139 GHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHGLRVRKKEVYMP--SS 196
Query: 235 ITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS---FEVQKYVLPKFELLIDP--------P 283
I F + D G W I + S FEV+KYVLP FE+ I P P
Sbjct: 197 IFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVP 256
Query: 284 RYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLR----TTKI-- 337
++ ++ ++ARY +GKPV G + G + + R TK+
Sbjct: 257 GHLDEMQL----DIQARYIYGKPVQGVAYVRF-----GLLDEDGKKTFFRGLESQTKLVN 307
Query: 338 ------LGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLV 391
L +F + + + + + R+ + A + G + +++ V
Sbjct: 308 GQSHISLSKAEFQDAL-EKLNMGITDLQGLRLYVAAAIIESPGGE---MEEAELTSWYFV 363
Query: 392 DIRYSKD---TRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQ 448
+S D T++ PG ++ + + GSPA G+ V++ A ++ ++ + + Q
Sbjct: 364 SSPFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDI-Q 422
Query: 449 RGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQ-PP 507
+ G SIP E ++ G P A + L++ + S +L ++ P
Sbjct: 423 QNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPA---IARLTVAAPPSGGPGFLSIERPD 479
Query: 508 SHPLQVGEEAYFSVKST-CPCNFT-LYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEK 565
S P +VG+ ++++ F+ YY + +RG IV ++P T
Sbjct: 480 SRPPRVGDTLNLNLRAVGSGATFSHYYYMILSRGQIVFMNREPKRT-------------- 525
Query: 566 PIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFA 625
+TS+ + V + P + FY VA+SL+
Sbjct: 526 -----------------------LTSVSVFVDHHLAPSFYFVAFYY-HGDHPVANSLRVD 561
Query: 626 VET-FFENQVSVTY-SANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLL--RSGFRLTP 681
V+ E ++ ++ A + + GE V L + + V + A+D ++Y +S L
Sbjct: 562 VQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNM 621
Query: 682 AQVFQELEDYD-------------VSDSFGVSREDGPFWWAGLTAQRRRRS 719
+VF+ + YD V + G++ DG W T R+R S
Sbjct: 622 GKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQW----TLSRKRLS 668
Score = 70.5 bits (171), Expect = 2e-11
Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 6/129 (4%)
Query: 791 RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFK 850
R+FFPE W+W + L++ +PDS+T+W ++LS ++GL +A P L+ F+
Sbjct: 775 RSFFPENWLWRVETVDRFQ---ILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFR 831
Query: 851 PFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMC 910
F + LP + R EQ+++ +YNY+ V + +S +G+ G G + +++
Sbjct: 832 EFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGGG---LAQQVL 888
Query: 911 VAPGEAEPI 919
V G A P+
Sbjct: 889 VPAGSARPV 897
>gi|239740686 PREDICTED: similar to C4A protein isoform 2 [Homo
sapiens]
Length = 1698
Score = 218 bits (555), Expect = 5e-56
Identities = 198/609 (32%), Positives = 283/609 (46%), Gaps = 65/609 (10%)
Query: 1154 VPHGAIPGSERATASIIGDVMGP----TLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYL 1209
+P G R TAS D +G + + +LLRLP GCGEQ MI+ AP + +YL
Sbjct: 969 IPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYL 1028
Query: 1210 QKTQQ---LSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
KT+Q L PE + D + +GY R +++ DGSY+A+ RD+S WLTAFVLK
Sbjct: 1029 DKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDSS--TWLTAFVLKVL 1086
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHG---TVPLTAYVV 1323
+ A+ + P +L +W++ QQQADGSF VL++ +QGG+ G TV LTA+V
Sbjct: 1087 SLAQEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVT 1146
Query: 1324 VALLETGTASEEERG----------STDKARHFL-ESAAPLAMDPYSCALTTYALTLLRS 1372
+A L G A ++ G S KA FL E A+ + ++ A+T YALTL ++
Sbjct: 1147 IA-LHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKA 1205
Query: 1373 PA--APEALRKLRSLAIMRDGVTHW-----SLSNSWDVDKGTFLSFSDRVSQSVVSAEVE 1425
P A L ++A +W S SN+ + SD + Q+ + +E
Sbjct: 1206 PVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAP-RNPSDPMPQA-PALWIE 1263
Query: 1426 MTAYALLTYTL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYA-- 1482
TAYALL L G A WL++Q + GGF STQDT +AL AL+ Y I S+
Sbjct: 1264 TTAYALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTE 1323
Query: 1483 -GGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVT 1541
G+N+T+S N +L+ + L+ SL + + V G+ +++ T
Sbjct: 1324 ERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRT 1383
Query: 1542 YNVPDPVAKPAFQLLVSLQEPEAQGRPP-PMPASA-AEGSRGDWPPADDDDPAADQHHQE 1599
YNV D L + E +G M A+ E D PA DD A Q
Sbjct: 1384 YNVLDMKNTTCQDLQI---EVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPLQ---- 1436
Query: 1600 YKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLF 1659
V L G N E P L+ L D++ + +E G VL
Sbjct: 1437 -----PVTPLQLFEGRRNRRRREAPKLTS-----------LSDRY--VSHFETEGPHVLL 1478
Query: 1660 YFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLARELC 1719
YFD +P+ CV F A++E VG ++YDYY P + FY + S L LC
Sbjct: 1479 YFDSVPT-SRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLC 1537
Query: 1720 AGPACNEVE 1728
+ C E
Sbjct: 1538 SAEVCQCAE 1546
Score = 93.6 bits (231), Expect = 2e-18
Identities = 152/711 (21%), Positives = 274/711 (38%), Gaps = 128/711 (18%)
Query: 76 QAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQG--------EPVVQ-SQGA 126
Q P L+ +PSV GV + V + + PR V+ + + P V + +
Sbjct: 19 QKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSS 78
Query: 127 ILDKGTIKLKVPTG----------LRGQALLKVWGRGWQAEEGPLFHNQTSVTV--DGRG 174
D + L+VP LRG + V W + N + + R
Sbjct: 79 ERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSRR 138
Query: 175 ASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCG 234
+F+QTD+P+Y P RV +F + +RP + + + + G R+ + P
Sbjct: 139 GHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHGLRVRKKEVYMP--SS 196
Query: 235 ITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS---FEVQKYVLPKFELLIDP--------P 283
I F + D G W I + S FEV+KYVLP FE+ I P P
Sbjct: 197 IFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVP 256
Query: 284 RYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLR----TTKI-- 337
++ ++ ++ARY +GKPV G + G + + R TK+
Sbjct: 257 GHLDEMQL----DIQARYIYGKPVQGVAYVRF-----GLLDEDGKKTFFRGLESQTKLVN 307
Query: 338 ------LGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLV 391
L +F + + + + + R+ + A + G + +++ V
Sbjct: 308 GQSHISLSKAEFQDAL-EKLNMGITDLQGLRLYVAAAIIEYPGGE---MEEAELTSWYFV 363
Query: 392 DIRYSKD---TRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQ 448
+S D T++ PG ++ + + GSPA G+ V++ A ++ ++ + + Q
Sbjct: 364 SSPFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDI-Q 422
Query: 449 RGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQ-PP 507
+ G SIP E ++ G P A + L++ + S +L ++ P
Sbjct: 423 QNTDGSGQVSIPIIIPQTISELQLSVSAGSPHPA---IARLTVAAPPSGGPGFLSIEWPD 479
Query: 508 SHPLQVGEEAYFSVKST-CPCNFT-LYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEK 565
S P +VG+ ++++ F+ YY + +RG IV ++P T
Sbjct: 480 SRPPRVGDTLNLNLRAVGSGATFSHYYYMILSRGQIVFMNREPKRT-------------- 525
Query: 566 PIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFA 625
+TS+ + V + P + FY VA+SL+
Sbjct: 526 -----------------------LTSVSVFVDHHLAPSFYFVAFYY-HGDHPVANSLRVD 561
Query: 626 VET-FFENQVSVTY-SANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLL--RSGFRLTP 681
V+ E ++ ++ A + + GE V L + + V + A+D ++Y +S L
Sbjct: 562 VQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNM 621
Query: 682 AQVFQELEDYD-------------VSDSFGVSREDGPFWWAGLTAQRRRRS 719
+VF+ + YD V + G++ DG W T R+R S
Sbjct: 622 GKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQW----TLSRKRLS 668
Score = 70.5 bits (171), Expect = 2e-11
Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 6/129 (4%)
Query: 791 RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFK 850
R+FFPE W+W + L++ +PDS+T+W ++LS ++GL +A P L+ F+
Sbjct: 775 RSFFPENWLWRVETVDRFQ---ILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRVFR 831
Query: 851 PFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMC 910
F + LP + R EQ+++ +YNY+ V + +S +G+ G G + +++
Sbjct: 832 EFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLCLAGGGG---LAQQVL 888
Query: 911 VAPGEAEPI 919
V G A P+
Sbjct: 889 VPAGSARPV 897
>gi|115298678 complement component 3 precursor [Homo sapiens]
Length = 1663
Score = 183 bits (464), Expect = 2e-45
Identities = 156/569 (27%), Positives = 256/569 (44%), Gaps = 74/569 (13%)
Query: 1181 LNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSP---EVERETTDYLVQGYQRQLTY 1237
L +L+ P GCGEQNMI P V + YL +T+Q E + + + +GY +QL +
Sbjct: 1000 LKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAF 1059
Query: 1238 KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWII-QQQQADGS 1296
++ +++AF +R + S WLTA+V+K F+ A + I +D + L A W+I ++Q+ DG
Sbjct: 1060 RQPSSAFAAFVKR--APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGV 1117
Query: 1297 FLAVGRVLNKDIQGGIHGT----VPLTAYVVVALLETGTASEEE----RGSTDKARHFLE 1348
F V+++++ GG+ + LTA+V+++L E EE+ GS KA FLE
Sbjct: 1118 FQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLE 1177
Query: 1349 SAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTF 1408
+ Y+ A+ YAL + P ++ +T N W+ D G
Sbjct: 1178 ANYMNLQRSYTVAIAGYALAQMGRLKGP----------LLNKFLTTAKDKNRWE-DPGKQ 1226
Query: 1409 LSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCV 1468
L VE T+YALL L D PVV+WL++QR GG+ STQ T +
Sbjct: 1227 LY------------NVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFM 1274
Query: 1469 ALQALAEYAI-LSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVS 1527
QALA+Y +NL VSL + + T +H + +L++ G V+
Sbjct: 1275 VFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKE-NEGFTVT 1333
Query: 1528 AKGDGCCLMQIDVTYNVP--DPVAKPAFQLLVSLQE-PEAQGRPPPMPASAAEGSRGDWP 1584
A+G G + + Y+ D + F L V+++ PE + RP
Sbjct: 1334 AEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRP---------------- 1377
Query: 1585 PADDDDPAADQHHQEYKVMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKH 1644
+ ++LE+CTR+ + M++L++ +++GF D + L+QL
Sbjct: 1378 -----------QDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVD 1426
Query: 1645 MGMKRYEV-----AGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPA 1699
+ +YE+ ++ Y D++ C+ F+ + V V VY YY
Sbjct: 1427 RYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLE 1486
Query: 1700 FEATRFYNVSTHSPLARELCAGPACNEVE 1728
TRFY+ +LC C E
Sbjct: 1487 ESCTRFYHPEKEDGKLNKLCRDELCRCAE 1515
Score = 119 bits (299), Expect = 2e-26
Identities = 169/691 (24%), Positives = 275/691 (39%), Gaps = 88/691 (12%)
Query: 58 PLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQA------ 111
P LLLLL + P Y I P++ R EE + + ++ +V V
Sbjct: 7 PSLLLLLLTHLPLALGSPM---YSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFP 63
Query: 112 --QLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTS-- 167
+LV E V + A G + +P + GR F Q
Sbjct: 64 GKKLVLSSEKTVLTP-ATNHMGNVTFTIPAN---REFKSEKGRNKFVTVQATFGTQVVEK 119
Query: 168 -VTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWR 226
V V + +FIQTDK +Y P VL IFTV+ L PV + I +P G + +
Sbjct: 120 VVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDS 179
Query: 227 HLKPFCCGITNMSFPLSDQPVLGEWFI---FVEMQGHAYNKSFEVQKYVLPKFELLIDPP 283
G+ +S+ + + +G+W I + ++ FEV++YVLP FE++++P
Sbjct: 180 LSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPT 239
Query: 284 R---YIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGS 340
YI + E T+ AR+ +GK V G + + G+ + P +
Sbjct: 240 EKFYYIYNEKGLEV-TITARFLYGKKVEGTAFV---IFGIQDGEQRISLPESLKRIPIED 295
Query: 341 RDFDICVRDMIPADVPEHFRGR------VSIWAMVTSVDGSQQVAFDDS-TPVQRQLVDI 393
++ + + D ++ R + + A V GS V + S P+ I
Sbjct: 296 GSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQI 355
Query: 394 RYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVG 453
++K T K FKPG+ + V ++ PDGSPA V V ++ E T + G+
Sbjct: 356 HFTK-TPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDT------VQSLTQGDGVAK 408
Query: 454 FEIPSIPTSAQ-HVWLETKVMALNGKPVGA---QYLPSYLSLGSWYSPSQCYLQLQPPSH 509
I + P+ + + TK L+ Q LP Y ++G+ S YL L
Sbjct: 409 LSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALP-YSTVGN----SNNYLHLSVLRT 463
Query: 510 PLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRL 569
L+ GE T NF L + A I + + RL
Sbjct: 464 ELRPGE--------TLNVNFLLRMDRAHEAKI---------------RYYTYLIMNKGRL 500
Query: 570 THLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEG----VADSLQFA 625
P + V L L++T +P RL+ +Y G VADS+
Sbjct: 501 LKAGRQVREPGQDLVV------LPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVD 554
Query: 626 VETFFENQVSVTYSANETQ---PGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPA 682
V+ + V +E + PG+ + L+I G+ V + AVDK V++L +LT +
Sbjct: 555 VKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQS 614
Query: 683 QVFQELEDYDVSDSFGVSRE-DGPFWWAGLT 712
+++ +E D+ + G ++ G F AGLT
Sbjct: 615 KIWDVVEKADIGCTPGSGKDYAGVFSDAGLT 645
Score = 72.0 bits (175), Expect = 5e-12
Identities = 43/155 (27%), Positives = 80/155 (51%), Gaps = 6/155 (3%)
Query: 791 RTFFPETWIWHCLNISDPSGEGT----LSVKVPDSITSWVGEAVALSTSQGLGIAEPSLL 846
R+ FPE+W+W+ ++ +P G +++ + DSIT+W AV++S +G+ +A+P +
Sbjct: 764 RSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEV 823
Query: 847 KTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVG-HPGKRHV 905
+ FF+D LP ++R EQV+I +YNY E+ +++ + F KR
Sbjct: 824 TVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQN-QELKVRVELLHNPAFCSLATTKRRH 882
Query: 906 TKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAY 940
+ + + P + + V+ GL + KA Y
Sbjct: 883 QQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVY 917
>gi|239744583 PREDICTED: ovostatin 2 [Homo sapiens]
Length = 1394
Score = 181 bits (459), Expect = 6e-45
Identities = 200/876 (22%), Positives = 372/876 (42%), Gaps = 115/876 (13%)
Query: 167 SVTVDGRGASVFIQTDKPVYRPQHR-------VLISIFTVS-PNLRPVNEKLEAYILDPR 218
SV + R VF+QTDKP Y+P + + +T + PN+ + DP+
Sbjct: 100 SVAIRSRENVVFVQTDKPTYKPGQKDVNGIAQFFLDTYTFTYPNIT---------LKDPQ 150
Query: 219 GSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGH-AYNKSFEVQKYVLPKFE 277
+R+ +W+++ F IT +SF L +P+ G+++I V+ F V++YVLPKFE
Sbjct: 151 NNRIFQWQNVTSFR-NITQLSFQLISEPMFGDYWIVVKRNSRKTVTHQFAVKRYVLPKFE 209
Query: 278 LLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKI 337
+ ++ P+ + D V A+YTFG+PV G I + + E + I
Sbjct: 210 VTVNAPQTVTISDDEFQVDVCAKYTFGQPVQGKTQIRVCREYFSSSNCEKNDNEICEQFI 269
Query: 338 LGSRDFDICVRDMIPADVPEHFRGRVSIWAMVTSV-----DGSQQVAFDDSTPVQ-RQLV 391
+ CV ++ V + +R + + V + G+ + + T V QL+
Sbjct: 270 AQLENG--CVSQIVNTKVFQLYRSGLFMTFHVAVIVTEFGTGNYCMQISEKTSVFITQLL 327
Query: 392 DIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGL 451
++ ++ G++Y G ++ S P+ P +Q++ D + + G
Sbjct: 328 GTVNFENMDTFYRRGISYFGTLKFSDPNNVPMVNKLLQLELN----DEFIGNYTTDENGE 383
Query: 452 VGFEI-------PSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQL 504
F I P A +V ++ + P QYL ++ + +YS + +L++
Sbjct: 384 AQFSIDTSDIFDPEFNLKATYVRPKSCYLPSWLTP---QYLDAHFLVSRFYSRTNSFLKI 440
Query: 505 QPPSHPLQVGEE----AYFSVKSTC---PCNFTLYYEVAARGNIVLSGQQPAHTTQQRSK 557
P L+ + ++S+ S N +Y V+ +H +
Sbjct: 441 VPEPKQLECNHQKVVTVHYSLNSEAYEDDSNVKFFYLVSL-----------SHDSGNFQH 489
Query: 558 RAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEG 617
R + + PI P L+++ + P L V+ + +GE
Sbjct: 490 RISSS---PIYTAWNGNFSFP---------------LSISADLAPAAVLFVYTLHPSGEI 531
Query: 618 VADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGF 677
VADS++F V+ F+++V++ +S + PG L ++AA + AVD +V LL+S
Sbjct: 532 VADSVRFQVDKCFKHKVNIKFSNEQGLPGSNASLYLQAAPVLFCALGAVDGNVLLLKSEQ 591
Query: 678 RLTPAQVFQELEDYDVSDSF--GVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSGF- 734
+L+ V+ + + F G++ +DG + + + ++ P D
Sbjct: 592 QLSAESVYNMVPSIEPYGYFYHGLNLDDGKEDPC-IPQRDMFYNGLYYTPVSNYGDGDIY 650
Query: 735 -AFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQP------HTGSLVAVAPSRHPPRTE 787
GL V T+ L++R+ + +P +P + G + +V PSR R E
Sbjct: 651 NIVRNMGLKVFTN---LHYRKPEVCVMERRLPLPKPLYLETENYGPMHSV-PSRIACRGE 706
Query: 788 KRK----------RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQG 837
RT FPETW+W +++ D SG LS +PD+IT W ++ G
Sbjct: 707 NADYVEQAIIQTVRTNFPETWMWDLVSV-DSSGSANLSFLIPDTITQWEASGFCVNGDVG 765
Query: 838 LGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFV 897
GI+ + L+ +PFF++ P +++ EQ + ++ ++Y+ TC E+ +++ + +
Sbjct: 766 FGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIVNAFSYLNTCVEISVQVEESQNYEAN 825
Query: 898 GHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEE 957
+ K + ++ A G IW ++ LG NIT A + + C +G +
Sbjct: 826 INTWKIN-GSEVIQAGGRKTNIWTIIP-KKLGKVNITVVAESKQSSACPNEGMEQQKLNW 883
Query: 958 NHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFC 993
D V +S +VE EG+ + T S C
Sbjct: 884 K----------DTVVKSFLVEPEGIEKERTQSFLIC 909
Score = 178 bits (451), Expect = 5e-44
Identities = 125/417 (29%), Positives = 203/417 (48%), Gaps = 16/417 (3%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
S+ L +P+ + GS R +++GD++G + +L +L++P+G GEQN A + +VL
Sbjct: 916 SKQGVLDLPNDVVEGSARGFFTVVGDILGLAMQNLV-VLQMPYGGGEQNAALLASDTYVL 974
Query: 1207 KYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
YL+ T+QL+ EV+ + L GYQRQL++K DGSYS F +++ GS+WL+A K+
Sbjct: 975 DYLKSTEQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQNQKGSIWLSALTFKTL 1034
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVAL 1326
+ + F+F+D W+ QQ+ G F G++ N +GG + LTAYVV
Sbjct: 1035 ERMKKFVFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDISLTAYVVGMF 1094
Query: 1327 LETGTASEEERGSTDKARHFLESAAPLAM-DPYSCALTTYALTLLRSPAAPEA-LRKLRS 1384
E G S + A LE+A + + Y+ A+ YA L E+ L+ L
Sbjct: 1095 FEAGLNSTFP--ALRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQ 1152
Query: 1385 LAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTY--TLLGDVAA 1442
A + V +W ++ F SF SA+ E + Y LL + D+
Sbjct: 1153 SATKLNNVIYWERERKPKTEE--FPSFIPWAP----SAQTEKSCYVLLAVISRKIPDLTY 1206
Query: 1443 ALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETF 1502
A +V+WL+QQ N+ GGFSS Q V L + AI G + + + + +
Sbjct: 1207 ASKIVQWLAQQMNSHGGFSSNQVINVGLILI---AICGEEGLFSKNQNTVTFSSEGSSEI 1263
Query: 1503 ELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSL 1559
+ + N+ ++Q + + P V +G GC +Q + YNV P F L + +
Sbjct: 1264 QFNGHNRLLVQRSEVTQAPGQYTVDVEGRGCTFIQATLKYNVLLPKKASGFSLSLEI 1320
>gi|169204289 PREDICTED: ovostatin [Homo sapiens]
Length = 1353
Score = 179 bits (454), Expect = 2e-44
Identities = 200/878 (22%), Positives = 376/878 (42%), Gaps = 119/878 (13%)
Query: 167 SVTVDGRGASVFIQTDKPVYRPQHR-------VLISIFTVS-PNLRPVNEKLEAYILDPR 218
SV + R VF+QTDKP Y+P + + +T + PN+ + DP+
Sbjct: 51 SVAIRSRENVVFVQTDKPTYKPGQKDVNGIAQFFLDTYTFTYPNIT---------LKDPQ 101
Query: 219 GSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGH-AYNKSFEVQKYVLPKFE 277
+R+ + +++ F IT +SF L +P+ G+++I V+ F V++YVLPKFE
Sbjct: 102 NNRIFQRQNVTSFR-NITQLSFQLISEPMFGDYWIVVKRNSRETVTHQFAVKRYVLPKFE 160
Query: 278 LLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKI 337
+ ++ P+ + D V A+Y FG+PV G I + + E + I
Sbjct: 161 VTVNAPQTVTISDDEFQVDVCAKYNFGQPVQGETQIRVCREYFSSSNCEKNENEICEQFI 220
Query: 338 LGSRDFDICVRDMIPADVPEHFRGRVSIW---AMVTSVDGS----QQVAFDDSTPVQRQL 390
+ CV ++ V + +R + + A++ + G+ Q++ S + + L
Sbjct: 221 AQLENG--CVSQIVNTKVFQLYRSGLFMTFHVAVIVTESGTGNYFMQISEKTSVFITQLL 278
Query: 391 VDIRYSK-DTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQR 449
+ + DT ++ G++Y G ++ S P+ P +Q++ D + +
Sbjct: 279 GTVNFENMDTF--YRRGISYFGTLKFSDPNNVPMVNKLLQLELN----DEFIGNYTTDEN 332
Query: 450 GLVGFEI-------PSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYL 502
G F I P A +V E+ + P QYL ++ + +YS + +L
Sbjct: 333 GEAQFSIDTSDIFDPEFNLKATYVRPESCYLPSWLTP---QYLDAHFLVSRFYSRTNSFL 389
Query: 503 QLQPPSHPLQVGEE----AYFSVKSTC---PCNFTLYYEVAARGNIVLSGQQPAHTTQQR 555
++ P L+ ++ ++S+ S N +Y V+ +H +
Sbjct: 390 KIVPEPKQLECNQQKVVTVHYSLNSEAYEDDSNVKFFYLVSL-----------SHDSGNF 438
Query: 556 SKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENG 615
R + + PI P ++++ + P L V+ + +G
Sbjct: 439 QHRISSS---PIYTAWNGNFSFP---------------ISISADLAPAAVLFVYTLHPSG 480
Query: 616 EGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRS 675
E VADS++F V+ F+++V++ +S + PG L ++AA + AVD++V LL+S
Sbjct: 481 EIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNASLCLQAAPVLFCALRAVDRNVLLLKS 540
Query: 676 GFRLTPAQVFQELEDYDVSDSF--GVSREDGPFWWAGLTAQRRRRSSVFPWPWGITKDSG 733
+L+ V+ + + F G++ +DG + + + ++ P D
Sbjct: 541 EQQLSAESVYNMVPSIEPYGYFYHGLNLDDGKEDPC-IPQRDMFYNGLYYTPVSNYGDGD 599
Query: 734 F--AFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQP------HTGSLVAVAPSRHPPR 785
GL V T+ L++R+ + +P +P + G + +V PSR R
Sbjct: 600 IYNIVRNMGLKVFTN---LHYRKPEVCVMERRLPLPKPLYLETENYGPMRSV-PSRIACR 655
Query: 786 TEKRK----------RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTS 835
E RT FPETW+W +++ D SG LS +PD+IT W ++
Sbjct: 656 GENADYVEQAIIQTVRTNFPETWMWDLVSV-DSSGSANLSFLIPDTITQWEASGFCVNGD 714
Query: 836 QGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQ 895
G GI+ + L+ +PFF++ P +++ EQ + ++V++Y TC E+ +++ + +
Sbjct: 715 VGFGISSTTTLEVSQPFFIEIASPFSVVQNEQFDLIVNVFSYRNTCVEISVQVEESQNYE 774
Query: 896 FVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHP 955
H K + ++ A G +W ++ LG NIT A + + C +G +
Sbjct: 775 ANIHTLKIN-GSEVIQAGGRKTNVWTIIP-KKLGKVNITVVAESKQSSACPNEGMEQQKL 832
Query: 956 EENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFC 993
D V +S +VE EG+ + T S C
Sbjct: 833 NWK----------DTVVQSFLVEPEGIEKERTQSFLIC 860
Score = 172 bits (436), Expect = 3e-42
Identities = 125/422 (29%), Positives = 202/422 (47%), Gaps = 18/422 (4%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
S+ L +P+ + GS R +++GD++G L +L +L++P+G GEQN A + +VL
Sbjct: 867 SKQGVLDLPNDVVEGSARGFFTVVGDILGLALQNLV-VLQMPYGSGEQNAALLASDTYVL 925
Query: 1207 KYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDASGSMWLTAFVLKSF 1266
YL+ T+QL+ EV+ + L GYQRQL++K DGSYS F ++ GS+ L+A K+
Sbjct: 926 DYLKSTEQLTEEVQSKAFFLLSNGYQRQLSFKNSDGSYSVFWQQSQKGSIXLSALTFKTL 985
Query: 1267 AQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVAL 1326
+ + ++F+D W+ QQ+ G F G++ N +GG + LTAYVV
Sbjct: 986 ERMKKYVFIDENVQKQTLIWLSSQQKTSGCFKNDGQLFNHAWEGGDEEDISLTAYVVGMF 1045
Query: 1327 LETGTASEEERGSTDKARHFLESAAPLAM-DPYSCALTTYALTLLRSPAAPEA-LRKLRS 1384
E G + A LE+A + + Y+ A+ YA L E+ L+ L
Sbjct: 1046 FEAGL--NFTFPALRNALFCLEAALDSGVTNGYNHAILAYAFALAGKEKQVESLLQTLDQ 1103
Query: 1385 LAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALLTY--TLLGDVAA 1442
A + V +W ++ F SF SA+ E + Y LL + D+
Sbjct: 1104 SAPKLNNVIYWERERKPKTEE--FPSFIPWAP----SAQTEKSCYVLLAVISRKIPDLTY 1157
Query: 1443 ALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDY---- 1498
A +V+WL+Q+ N+ GGFSS Q V L +A + A G S + +
Sbjct: 1158 ASKIVQWLAQRMNSHGGFSSNQVINVGLILIAICLMQKLARGEEGLFSKDQNTVTFSSEG 1217
Query: 1499 -QETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLV 1557
E F+++ N+ ++Q + + P V +G GC +Q + YNV P F L +
Sbjct: 1218 SSEIFQVNGHNRLLVQRSEVTQAPGEYTVDVEGHGCTFIQATLKYNVLLPKKASGFSLSL 1277
Query: 1558 SL 1559
+
Sbjct: 1278 EI 1279
>gi|239758130 PREDICTED: similar to complement component 4B (Childo
blood group), partial [Homo sapiens]
Length = 666
Score = 168 bits (425), Expect = 5e-41
Identities = 162/522 (31%), Positives = 235/522 (45%), Gaps = 60/522 (11%)
Query: 1259 TAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHG---T 1315
TAFVLK + A+ + +L +W++ QQQADGSF + V+++ +QGG+ G T
Sbjct: 1 TAFVLKVLSLAQEQVGGSREKLQETSNWLLSQQQADGSFQDLSPVIHRSMQGGLVGNDET 60
Query: 1316 VPLTAYVVVALLETGTASEEERG----------STDKARHFL-ESAAPLAMDPYSCALTT 1364
V LTA+V +A L G A ++ G S KA FL E A+ + ++ A+T
Sbjct: 61 VALTAFVTIA-LHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITA 119
Query: 1365 YALTLLRSPAAPEALRKLRSLAIMRD-------GVTHWSLSNSWDVDKGTFLSFSDRVSQ 1417
YALTL ++PA + +A+ ++ G S SN+ + SD + Q
Sbjct: 120 YALTLTKAPADLRGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTPAP-RNPSDPMPQ 178
Query: 1418 SVVSAEVEMTAYALLTYTL-LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEY 1476
+ + +E TAYALL L G A WL++Q + GGF STQDT +AL AL+ Y
Sbjct: 179 A-PALWIETTAYALLHLLLHEGKAEMADQAAAWLTRQGSFQGGFRSTQDTVIALDALSAY 237
Query: 1477 AILSYA---GGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGC 1533
I S+ G+N+T+S N +L+ + L+ SL + + V G+
Sbjct: 238 WIASHTTEERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEEELQFSLGSKINVKVGGNSK 297
Query: 1534 CLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPP-PMPASA-AEGSRGDWPPADDDDP 1591
+++ TYNV D L + E +G M A+ E D PA DD
Sbjct: 298 GTLKVLRTYNVLDMKNTTCQDLQI---EVTVKGHVEYTMEANEDYEDYEYDELPAKDDPD 354
Query: 1592 AADQ-----------------------HHQEYKVMLEVCTRWLH--AGSSNMAVLEVPLL 1626
A Q QE +V VC W + G S MA+ +V LL
Sbjct: 355 APLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVCI-WRNGKVGLSGMAIADVTLL 413
Query: 1627 SGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTS 1686
SGF A LE+L + +E G VL YFD +P+ CV F A++E VG
Sbjct: 414 SGFHALRADLEKLTSLSDRYVSHFETEGPHVLLYFDSVPT-SRECVGFEAVQEVPVGLVQ 472
Query: 1687 ALPVSVYDYYEPAFEATRFYNVSTHSPLARELCAGPACNEVE 1728
++YDYY P + FY + S L LC+ C E
Sbjct: 473 PASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAE 514
>gi|38016947 complement component 5 preproprotein [Homo sapiens]
Length = 1676
Score = 145 bits (367), Expect = 3e-34
Identities = 157/619 (25%), Positives = 265/619 (42%), Gaps = 78/619 (12%)
Query: 1145 SYSEAFTLGVPHGAIPGSE-----RATASIIGDVMGPTLNH--LNNLLRLPFGCGEQNMI 1197
S + F +P +P +E ++G+++ L+ +N L LP G E ++
Sbjct: 954 SRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELM 1013
Query: 1198 HFAPNVFVLKYLQKTQQLS-----PEVERETTDY-LVQGYQRQLTYKRQDGSYSAFGERD 1251
P +V YL+ + P +E++ L +G ++Y+ D SYS + +
Sbjct: 1014 SVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVW--KG 1071
Query: 1252 ASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQAD-GSFLAVGRVLNKDIQG 1310
S S WLTAF L+ Q ++ + + + W+++ Q D GSF + +QG
Sbjct: 1072 GSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQG 1131
Query: 1311 GI-----HGTVPLTAYVVVALLETGTASEEERGSTD--KARHFLESAAPLAMDPYSCALT 1363
+ ++ LTA+ V+ + + + T KA +FL A ++ A++
Sbjct: 1132 TLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAIS 1191
Query: 1364 TYALTLLRSPAAPEALRKLRSL--AIMRDGVTHWS--LSNSWDVDKGTFLSFSDRVSQSV 1419
YAL+L + + RS+ A+ R+ + + + W K V +
Sbjct: 1192 AYALSL-----GDKTHPQFRSIVSALKREALVKGNPPIYRFW---KDNLQHKDSSVPNTG 1243
Query: 1420 VSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAIL 1479
+ VE TAYALLT L D+ PV+KWLS+++ GGF STQDT A++ L EY++L
Sbjct: 1244 TARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLL 1303
Query: 1480 SYAGGINLTVSLASTNLDYQETFELHR---TNQKVLQTAAIPSLPTGLFVSAKGDGCCLM 1536
+++ + ++ Y+ LH T++ L L L VS G G L
Sbjct: 1304 VKQLRLSMDI-----DVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVST-GFGSGLA 1357
Query: 1537 QIDVTYNVPDPVAKP---AFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAA 1593
+ VT V +F L + Q+ E A RG
Sbjct: 1358 TVHVTTVVHKTSTSEEVCSFYLKIDTQDIE------------ASHYRG------------ 1393
Query: 1594 DQHHQEYKVMLEVC----TRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKR 1649
+ +YK ++ +R + S+ AV+++ L +G A+ E L+ L+
Sbjct: 1394 -YGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTD 1452
Query: 1650 YEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVS 1709
Y++ V+ + IPS CVRFR VG S +VY+Y+ P + T FY S
Sbjct: 1453 YQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFY--S 1510
Query: 1710 THSPLARELCAGPACNEVE 1728
T + +++C G AC VE
Sbjct: 1511 TSNIKIQKVCEGAACKCVE 1529
Score = 139 bits (349), Expect = 3e-32
Identities = 198/919 (21%), Positives = 356/919 (38%), Gaps = 172/919 (18%)
Query: 76 QAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKL 135
Q Y+I+AP +FR G E I + ++ + + + G + L
Sbjct: 19 QEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFS-----YSSGHVHL 73
Query: 136 KVPTGLRGQALLKVWGRGWQAEEGPL-----------FHNQTSVTVDGRGASVFIQTDKP 184
+ A+L + + + P+ F + + +FI TDKP
Sbjct: 74 SSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKP 133
Query: 185 VYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNM-SFPLS 243
VY P V + +++++ +L+P + +DP GS + + GI + F +
Sbjct: 134 VYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI--GIISFPDFKIP 191
Query: 244 DQPVLGEWFIFVEMQ------GHAYNKSFEVQKYVLPKFELLIDPPRYIQDLDACETG-- 295
P G W I + + G AY FEV++YVLP F + I+P +
Sbjct: 192 SNPRYGMWTIKAKYKEDFSTTGTAY---FEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEI 248
Query: 296 TVRARYTFGKPVAGA-LMINMTVN-GVGYYSHEVGRPVLRTTKILG-----SRDFDICVR 348
T++ARY + K V A + I + + E+ + ++ T ++ + D + V+
Sbjct: 249 TIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVK 308
Query: 349 DMIPADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTP-VQRQLVDIRYSKDTRKQF-KPG 406
++ + + ++ VT ++ + + + P ++ L + + F KPG
Sbjct: 309 ELSYYSLED--LNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPG 366
Query: 407 LAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVGFE------IPSIP 460
+ Y KV++ GV V + A+ T N TS++ + + + + ++P
Sbjct: 367 IPYPIKVQVKDSLDQLVGGVPVTLNAQ-TIDVNQETSDLDPSKSVTRVDDGVASFVLNLP 425
Query: 461 TSAQHVWLETKVMALNGKPVGAQYLPSYLSLG-SWYSPSQCYLQLQPPSHPLQVGEEAYF 519
+ + K A + P Q Y ++ S S S Y+ L VGE
Sbjct: 426 SGVTVLEFNVKTDAPD-LPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNI 484
Query: 520 SVKSTCPC--NFTLY-YEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETE 576
V P T Y Y + ++G I+ G +
Sbjct: 485 IVTPKSPYIDKITHYNYLILSKGKIIHFGTR----------------------------- 515
Query: 577 PPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYV---RENGEGVADSLQFAVETFFENQ 633
E D S+++ VT +MVP RLLV+Y+ + E V+DS+ +E NQ
Sbjct: 516 -----EKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQ 570
Query: 634 VSVTYS--ANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQV--FQELE 689
+ V S A+ PG+ V L + S V +AAVD +VY ++ G + +V F E
Sbjct: 571 LQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKS 630
Query: 690 DYDVSDSFGVSREDGPFWWAGL--------------------------TAQRRRRSSVFP 723
D G++ + F AGL T Q++
Sbjct: 631 DLGCGAGGGLNNAN-VFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAK 689
Query: 724 WPWGITKDSGF--------------------------AFTETGLVVMTDRVSLNHR--QD 755
+ + K + AFTE +V R +++H+ Q
Sbjct: 690 YKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQL 749
Query: 756 GGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHCLNISDPSGEGTLS 815
G L+ +P +P R++FPE+W+W + L
Sbjct: 750 GRLHMKTLLPVSKPEI-------------------RSYFPESWLWEVHLVPRRK---QLQ 787
Query: 816 VKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVY 875
+PDS+T+W + V +S + G+ +A+ K FK F++ +P ++RGEQ+++ +VY
Sbjct: 788 FALPDSLTTWEIQGVGISNT-GICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVY 846
Query: 876 NYMGTCAEVYMKLSVPKGI 894
NY + + +K+S +GI
Sbjct: 847 NYRTSGMQFCVKMSAVEGI 865
>gi|169218213 PREDICTED: similar to complement component C3, partial
[Homo sapiens]
Length = 1295
Score = 140 bits (352), Expect = 2e-32
Identities = 101/308 (32%), Positives = 156/308 (50%), Gaps = 37/308 (12%)
Query: 1181 LNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSP---EVERETTDYLVQGYQRQLTY 1237
L +L+ P GCGEQNMI P V + YL +T+Q E + + + +GY +QL +
Sbjct: 1000 LKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAF 1059
Query: 1238 KRQDGSYSAFGERDASGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWII-QQQQADGS 1296
++ +++AF +R + S WLTA+V+K F+ A + I +D + L A W+I ++Q+ DG
Sbjct: 1060 RQPSSAFAAFVKR--APSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGV 1117
Query: 1297 FLAVGRVLNKDIQGGIHGT----VPLTAYVVVALLETGTASEEE----RGSTDKARHFLE 1348
F V+++++ GG+ + LTA+V+++L E EE+ GS KA FLE
Sbjct: 1118 FQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLE 1177
Query: 1349 SAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTF 1408
+ Y+ A+ YAL + P ++ +T N W+ D G
Sbjct: 1178 ANYMNLQRSYTVAIAGYALAQMGRLKGP----------LLNKFLTTAKDKNRWE-DPGKQ 1226
Query: 1409 LSFSDRVSQSVVSAEVEMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCV 1468
L VE T+YALL L D PVV+WL++QR GG+ STQ T +
Sbjct: 1227 LY------------NVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFM 1274
Query: 1469 ALQALAEY 1476
QALA+Y
Sbjct: 1275 VFQALAQY 1282
Score = 121 bits (303), Expect = 8e-27
Identities = 169/691 (24%), Positives = 275/691 (39%), Gaps = 88/691 (12%)
Query: 58 PLLLLLLSARDGVRAAQPQAPGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQA------ 111
P LLLLL + P Y I P++ R EE + + ++ +V V
Sbjct: 7 PSLLLLLLTHLPLALGSPM---YSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFP 63
Query: 112 --QLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTS-- 167
+LV E V + A G + +P + GR F Q
Sbjct: 64 GKKLVLSSEKTVLTP-ATNHMGNVTFTIPAN---REFKSEKGRNKFVTVQATFGTQVVEK 119
Query: 168 -VTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWR 226
V V + +FIQTDK +Y P VL IFTV+ L PV + I +P G + +
Sbjct: 120 VVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDS 179
Query: 227 HLKPFCCGITNMSFPLSDQPVLGEWFI---FVEMQGHAYNKSFEVQKYVLPKFELLIDPP 283
G+ +S+ + + +G+W I + ++ FEV++YVLP FE++++P
Sbjct: 180 LSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPT 239
Query: 284 R---YIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGS 340
YI + E T+ AR+ +GK V G + + G+ + P +
Sbjct: 240 EKFYYIYNEKGLEV-TITARFLYGKKVEGTAFV---IFGIQDGEQRISLPESLKRIPIED 295
Query: 341 RDFDICVRDMIPADVPEHFRGR------VSIWAMVTSVDGSQQVAFDDS-TPVQRQLVDI 393
++ + + D ++ R + + A V GS V + S P+ I
Sbjct: 296 GSGEVVLSRKVLLDGVQNLRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQI 355
Query: 394 RYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYTSEVVSQRGLVG 453
++K T K FKPG+ + V ++ PDGSPA V V ++ E T + G+
Sbjct: 356 HFTK-TPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDT------VQSLTQGDGVAK 408
Query: 454 FEIPSIPTSAQ-HVWLETKVMALNGKPVGA---QYLPSYLSLGSWYSPSQCYLQLQPPSH 509
I + P+ + + TK L+ Q LP Y ++G+ S YL L
Sbjct: 409 LSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALP-YSTVGN----SNNYLHLSVLRT 463
Query: 510 PLQVGEEAYFSVKSTCPCNFTLYYEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRL 569
L+ GE T NF L + A I + + RL
Sbjct: 464 ELRPGE--------TLNVNFLLRMDRAHEAKI---------------RYYTYLIMNKGRL 500
Query: 570 THLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEG----VADSLQFA 625
P + V L L++T +P RL+ +Y G VADS+
Sbjct: 501 LKAGRQVREPGQDLVV------LPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVD 554
Query: 626 VETFFENQVSVTYSANETQ---PGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPA 682
V+ + V +E + PG+ + L+I G+ V + AVDK V++L +LT +
Sbjct: 555 VKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQS 614
Query: 683 QVFQELEDYDVSDSFGVSRE-DGPFWWAGLT 712
+++ +E D+ + G ++ G F AGLT
Sbjct: 615 KIWDVVEKADIGCTPGSGKDYAGVFSDAGLT 645
Score = 72.0 bits (175), Expect = 5e-12
Identities = 43/155 (27%), Positives = 80/155 (51%), Gaps = 6/155 (3%)
Query: 791 RTFFPETWIWHCLNISDPSGEGT----LSVKVPDSITSWVGEAVALSTSQGLGIAEPSLL 846
R+ FPE+W+W+ ++ +P G +++ + DSIT+W AV++S +G+ +A+P +
Sbjct: 764 RSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEV 823
Query: 847 KTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVG-HPGKRHV 905
+ FF+D LP ++R EQV+I +YNY E+ +++ + F KR
Sbjct: 824 TVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQN-QELKVRVELLHNPAFCSLATTKRRH 882
Query: 906 TKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAY 940
+ + + P + + V+ GL + KA Y
Sbjct: 883 QQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVY 917
>gi|239750255 PREDICTED: similar to ovostatin-2 [Homo sapiens]
Length = 750
Score = 117 bits (292), Expect = 1e-25
Identities = 105/439 (23%), Positives = 188/439 (42%), Gaps = 67/439 (15%)
Query: 591 SLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVD 650
S L+++ + P L V+ + +GE VADS++F V+ F+++V++ +S + PG
Sbjct: 145 SFPLSISADLAPAAVLFVYTLHPSGEIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNAS 204
Query: 651 LRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAG 710
L ++AA + AVD +V LL+S +L+ V+ + S E +++ G
Sbjct: 205 LYLQAAPVLFCALGAVDGNVLLLKSEQQLSAESVYNMVP----------SIEPYGYFYHG 254
Query: 711 LTAQRRRRSSVFPWPWGITKD---SGFAFTET---------------GLVVMTDRVSLNH 752
L + P +D +G +T GL V T+ L++
Sbjct: 255 LNLDDGKEDPCIP-----QRDMFYNGLYYTPVSNYGDGDIYNIVRNMGLKVFTN---LHY 306
Query: 753 RQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPP--------RTEKRK----------RTFF 794
R+ + +P +P P P R E RT F
Sbjct: 307 RKPEVCVMERRLPLPKPLYLETENYGPMHSVPSRIASSGIRGENADYVEQAIIQTVRTNF 366
Query: 795 PETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFV 854
PETW+W +++ D SG LS +PD+IT W ++ G GI+ + L+ +PFF+
Sbjct: 367 PETWMWDLVSV-DSSGSANLSFLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQPFFI 425
Query: 855 DFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPKGIQFVGHPGKRHVTKKMCVAPG 914
+ P +++ EQ + ++ ++Y+ TC E+ +++ + + + K + ++ A G
Sbjct: 426 EIASPFSVVQNEQFDLIVNAFSYLNTCVEISVQVEESQNYEANINTWKIN-GSEVIQAGG 484
Query: 915 EAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRS 974
IW ++ LG NIT A + + C +G + D V +S
Sbjct: 485 RKTNIWTIIP-KKLGKVNITVVAESKQSSACPNEGMEQQKLNWK----------DTVVKS 533
Query: 975 VMVEAEGVPRAYTYSAFFC 993
+VE EG+ + T S C
Sbjct: 534 FLVEPEGIEKERTQSFLIC 552
Score = 56.2 bits (134), Expect = 3e-07
Identities = 27/74 (36%), Positives = 48/74 (64%), Gaps = 1/74 (1%)
Query: 1147 SEAFTLGVPHGAIPGSERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVL 1206
S+ L +P+ + GS R +++GD++G + +L +L++P+G GEQN A + +VL
Sbjct: 559 SKQGVLDLPNDVVEGSARGFFTVVGDILGLAMQNLV-VLQMPYGGGEQNAALLASDTYVL 617
Query: 1207 KYLQKTQQLSPEVE 1220
YL+ T+QL+ EV+
Sbjct: 618 DYLKSTEQLTEEVQ 631
>gi|169217711 PREDICTED: similar to Ovostatin homolog 2 [Homo
sapiens]
Length = 278
Score = 79.0 bits (193), Expect = 4e-14
Identities = 33/98 (33%), Positives = 59/98 (60%), Gaps = 1/98 (1%)
Query: 791 RTFFPETWIWHCLNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFK 850
RT FPETW+W +++ D SG LS +PD+IT W ++ G GI+ + L+ +
Sbjct: 68 RTNFPETWMWDLVSV-DSSGSANLSFLIPDTITQWEASGFCVNGDVGFGISSTTTLEVSQ 126
Query: 851 PFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKL 888
PFF++ P +++ EQ + ++V++Y TC E+ +++
Sbjct: 127 PFFIEIASPFSVVQNEQFDLIVNVFSYRNTCVEISVQV 164
>gi|239754277 PREDICTED: similar to Complement component 4A (Rodgers
blood group) [Homo sapiens]
Length = 270
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 17/152 (11%)
Query: 173 RGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFC 232
R +F+QTD+P+Y P RV +F + +RP + + + + G R+ + P
Sbjct: 57 RRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHGLRVRKKEVYMP-- 114
Query: 233 CGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKS---FEVQKYVLPKFELLIDP------- 282
I F + D G W I + S FEV+KYVLP FE+ I P
Sbjct: 115 SSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILT 174
Query: 283 -PRYIQDLDACETGTVRARYTFGKPVAGALMI 313
P ++ ++ ++ARY +GKPV G +
Sbjct: 175 VPGHLDEMQL----DIQARYIYGKPVQGVAYV 202
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 60.8 bits (146), Expect = 1e-08
Identities = 62/191 (32%), Positives = 74/191 (38%), Gaps = 32/191 (16%)
Query: 1667 RCLTCVRFRALRECVVGR--------TSALPVSVYDYYEPAFEATRFYNVSTHSPLAREL 1718
RC C RF AL E GR A PV D + E + TH
Sbjct: 536 RCGQC-RFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVA 594
Query: 1719 CAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVY 1778
AGP + A G +G V P C+H PVCGSDGV Y
Sbjct: 595 SAGPCETCGDAVCAFGAVC---SAGQCVCPR---------CEHP---PPGPVCGSDGVTY 639
Query: 1779 ASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGA 1838
SAC LREAAC Q +E A C EQ S S G+D G +Q++
Sbjct: 640 GSACELREAACLQQTQIEEARAGPC--EQAECGSGGSGSGED------GDCEQELCRQRG 691
Query: 1839 GLEVEDSDPEP 1849
G+ EDS+ P
Sbjct: 692 GIWDEDSEDGP 702
Score = 48.1 bits (113), Expect = 8e-05
Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 1749 EEGAAIARCGCDHDC-GAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCC 1803
+E + C CD C G+PVCGSDGV Y++ C L++A C L A C
Sbjct: 695 DEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGAC 750
Score = 47.8 bits (112), Expect = 1e-04
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 39/174 (22%)
Query: 1720 AGPACNEVERAPARGP-GWFPGESGPAVAPE----------EGAAIARCGCDHDCGAQGN 1768
AGP C + A GP G S PA E E + A C C + N
Sbjct: 873 AGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEAN 932
Query: 1769 P--VCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQRLPASSSSTYGDDLASVAP 1826
VCGSDGV Y + C+L+ ACRQ + S + G +VAP
Sbjct: 933 ATKVCGSDGVTYGNECQLKTIACRQGLQI-----------------SIQSLGPCQEAVAP 975
Query: 1827 G--PLQQDVKLNGAGLEVEDSDPEPEGEAEDRVTAGPRPPVSSGNLESSTQSAS 1878
P V + GL + + P P G A P P S+ + +++ +S
Sbjct: 976 STHPTSASVTVTTPGLLLSQALPAPPG-------ALPLAPSSTAHSQTTPPPSS 1022
Score = 46.6 bits (109), Expect = 2e-04
Identities = 21/49 (42%), Positives = 25/49 (51%)
Query: 1755 ARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCC 1803
A C C C + +PVCGSDGV Y SAC L AC ++ A C
Sbjct: 486 AACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPC 534
Score = 40.0 bits (92), Expect = 0.022
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 9/60 (15%)
Query: 1756 RCGCDH-DCGAQGNPVCGSDGVVYASACRLREAACRQ--------AAPLEPAPPSCCALE 1806
RC CD C PVC DG Y S C ++A CRQ P + AP C ++
Sbjct: 413 RCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQ 472
Score = 38.1 bits (87), Expect = 0.084
Identities = 26/80 (32%), Positives = 35/80 (43%), Gaps = 4/80 (5%)
Query: 1750 EGAAIARCGCDHD-CGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALEQR 1808
EG A C C C + PVCGSD Y++ C L+ A C Q + C R
Sbjct: 188 EGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCG--SR 245
Query: 1809 LPASS-SSTYGDDLASVAPG 1827
P S+ + ++G A A G
Sbjct: 246 DPCSNVTCSFGSTCARSADG 265
Score = 37.0 bits (84), Expect = 0.19
Identities = 26/75 (34%), Positives = 29/75 (38%), Gaps = 2/75 (2%)
Query: 1743 GPAVAPEEGAAIARCGCDHDC-GAQGNPVCGSDGVVYASACRLREAAC-RQAAPLEPAPP 1800
G A A C C C GA VCGSDG Y C+L AC RQ +
Sbjct: 256 GSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDG 315
Query: 1801 SCCALEQRLPASSSS 1815
C + LP S S
Sbjct: 316 PCDPCQGALPDPSRS 330
>gi|169214179 PREDICTED: similar to complement component 3 [Homo
sapiens]
Length = 390
Score = 58.2 bits (139), Expect = 8e-08
Identities = 55/252 (21%), Positives = 100/252 (39%), Gaps = 36/252 (14%)
Query: 1485 INLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNV 1544
+NL VSL + + T +H + +L++ G V+A+G G + + Y+
Sbjct: 19 LNLDVSLQLPSRSSKITHRIHWESASLLRSEETKE-NEGFTVTAEGKGQGTLSVVTMYHA 77
Query: 1545 P--DPVAKPAFQLLVSLQE-PEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYK 1601
D + F L V+++ PE + RP +
Sbjct: 78 KAKDQLTCNKFDLKVTIKPAPETEKRP---------------------------QDAKNT 110
Query: 1602 VMLEVCTRWLHAGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEV-----AGRR 1656
++LE+CTR+ + M++L++ +++GF D + L+QL + +YE+
Sbjct: 111 MILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNT 170
Query: 1657 VLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHSPLAR 1716
++ Y D++ C+ F+ + V V VY YY TRFY+
Sbjct: 171 LIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLN 230
Query: 1717 ELCAGPACNEVE 1728
+LC C E
Sbjct: 231 KLCRDELCRCAE 242
>gi|239755748 PREDICTED: ovostatin [Homo sapiens]
Length = 257
Score = 55.1 bits (131), Expect = 7e-07
Identities = 58/227 (25%), Positives = 91/227 (40%), Gaps = 39/227 (17%)
Query: 1487 LTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPD 1546
L+VS AS + E F+++ N+ ++Q + + P V +G GC +Q + YNV
Sbjct: 66 LSVS-ASRSEGSSEIFQVNGHNRLLVQRSEVTQAPGQYTVDVEGHGCTFIQATLKYNVLL 124
Query: 1547 PVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEV 1606
P F L + + + ++ L V
Sbjct: 125 PKKASGFSLSLEIVK----------------------------------NYSSTAFDLTV 150
Query: 1607 CTRWLHA-GSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIP 1665
++ S+M V++V +LSGF + S+E+L +K MK EV VLFY +
Sbjct: 151 TLKYTGIRNKSSMVVIDVKMLSGFTPTMSSIEELE-NKGQVMKT-EVKNDHVLFYLENGF 208
Query: 1666 SRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHS 1712
R F + +V P VYDYYE A FYN+ + S
Sbjct: 209 GRA-DSFPFSVEQSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSS 254
>gi|239752557 PREDICTED: similar to Ovostatin homolog 2 [Homo
sapiens]
Length = 261
Score = 53.9 bits (128), Expect = 1e-06
Identities = 30/94 (31%), Positives = 55/94 (58%)
Query: 591 SLHLAVTPSMVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVD 650
S L+++ + P L V+ + +GE VADS++F V+ F+++V++ +S + PG
Sbjct: 145 SFPLSISADLAPAAVLFVYTLHPSGEIVADSVRFQVDKCFKHKVNIKFSNEQGLPGSNAS 204
Query: 651 LRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQV 684
L ++AA + AVD++V LL+S +L+ V
Sbjct: 205 LCLQAAPVLFCALRAVDRNVLLLKSEQQLSAESV 238
>gi|169205183 PREDICTED: similar to hCG38149 [Homo sapiens]
Length = 95
Score = 45.8 bits (107), Expect = 4e-04
Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 3/95 (3%)
Query: 1618 MAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRAL 1677
M V++V +LSGF + S+E+L +K MK EV VLFY + R F
Sbjct: 1 MVVIDVKMLSGFTPTMSSIEELE-NKGQVMKT-EVKNDHVLFYLENGFGRA-DSFPFSVE 57
Query: 1678 RECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHS 1712
+ +V P VYDYYE A FYN+ + S
Sbjct: 58 QSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSS 92
>gi|239744557 PREDICTED: hypothetical protein LOC728715 [Homo sapiens]
Length = 95
Score = 45.8 bits (107), Expect = 4e-04
Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 3/95 (3%)
Query: 1618 MAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRAL 1677
M V++V +LSGF + S+E+L +K MK EV VLFY + R F
Sbjct: 1 MVVIDVKMLSGFTPTMSSIEELE-NKGQVMKT-EVKNDHVLFYLENGFGRA-DSFPFSVE 57
Query: 1678 RECVVGRTSALPVSVYDYYEPAFEATRFYNVSTHS 1712
+ +V P VYDYYE A FYN+ + S
Sbjct: 58 QSNLVFNIQPAPAMVYDYYEKEEYALAFYNIDSSS 92
>gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
Length = 374
Score = 43.9 bits (102), Expect = 0.002
Identities = 19/50 (38%), Positives = 26/50 (52%)
Query: 1757 CGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQAAPLEPAPPSCCALE 1806
C C C PVCGS+G Y + C LR+AAC+Q + + CA +
Sbjct: 89 CVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATD 138
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/49 (38%), Positives = 30/49 (61%), Gaps = 1/49 (2%)
Query: 1749 EEGAAIARCGCDHDCGAQG-NPVCGSDGVVYASACRLREAACRQAAPLE 1796
+E A C C+ DC NP+C SDG Y +AC+++EA+C++ +E
Sbjct: 172 DEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIE 220
>gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 0.004
Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Query: 1746 VAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACR 1790
V E+G + +C C C PVCGS+G Y + C LR AAC+
Sbjct: 87 VCKEDGDGL-KCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACK 130
Score = 41.2 bits (95), Expect = 0.010
Identities = 20/42 (47%), Positives = 25/42 (59%), Gaps = 1/42 (2%)
Query: 1749 EEGAAIARCGCDHDC-GAQGNPVCGSDGVVYASACRLREAAC 1789
+E A C C+ DC G NPVC SDG Y + C +REA+C
Sbjct: 180 DEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASC 221
>gi|169217713 PREDICTED: similar to Ovostatin homolog 2 [Homo sapiens]
Length = 189
Score = 41.6 bits (96), Expect = 0.008
Identities = 37/120 (30%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1358 YSCALTTYALTLLRSPAAPEAL-RKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVS 1416
Y+ A+ YA L E+L + L A + V +W ++ F SF
Sbjct: 69 YNHAILAYAFALAGKEKQVESLLQTLDQSATKLNNVIYWERERKPKTEE--FPSFIPWAP 126
Query: 1417 QSVVSAEVEMTAYALLTYTL--LGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALA 1474
SA+ E + Y LL + D+ A +V+WL+QQ N+ GGFSS Q V L +A
Sbjct: 127 ----SAQTEKSCYVLLAVISRKIPDLTYASKIVQWLAQQMNSHGGFSSNQVINVGLILIA 182
>gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]
Length = 263
Score = 40.8 bits (94), Expect = 0.013
Identities = 24/54 (44%), Positives = 24/54 (44%), Gaps = 6/54 (11%)
Query: 1741 ESGPAVAPEEGAAIARCGCDHDCGAQGNP----VCGSDGVVYASACRLREAACR 1790
E GP A RC C DC G P VCGSDG Y C LR A CR
Sbjct: 103 ECGPGKACRMLGGRPRCECAPDCS--GLPARLQVCGSDGATYRDECELRAARCR 154
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,989,555
Number of Sequences: 37866
Number of extensions: 4225821
Number of successful extensions: 18577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 17406
Number of HSP's gapped (non-prelim): 933
length of query: 1932
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1815
effective length of database: 13,817,196
effective search space: 25078210740
effective search space used: 25078210740
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.