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Search of human proteins with 118498362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118498362 kinectin 1 isoform b [Homo sapiens]
(1306 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118498362 kinectin 1 isoform b [Homo sapiens] 2487 0.0
gi|118498356 kinectin 1 isoform a [Homo sapiens] 2459 0.0
gi|33620775 kinectin 1 isoform a [Homo sapiens] 2459 0.0
gi|118498368 kinectin 1 isoform c [Homo sapiens] 2403 0.0
gi|110611218 ribosome binding protein 1 [Homo sapiens] 239 2e-62
gi|110611220 ribosome binding protein 1 [Homo sapiens] 239 2e-62
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 183 1e-45
gi|71061468 centromere protein E [Homo sapiens] 167 8e-41
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 166 1e-40
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 166 2e-40
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 165 2e-40
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 165 2e-40
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 162 1e-39
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 161 3e-39
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 161 3e-39
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 160 6e-39
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 159 2e-38
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 159 2e-38
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 159 2e-38
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 159 2e-38
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 159 2e-38
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 158 3e-38
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 157 5e-38
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 152 2e-36
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 152 2e-36
gi|4506751 restin isoform a [Homo sapiens] 152 3e-36
gi|55770834 centromere protein F [Homo sapiens] 152 3e-36
gi|38044112 restin isoform b [Homo sapiens] 151 3e-36
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 150 1e-35
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 148 3e-35
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 2487 bits (6447), Expect = 0.0
Identities = 1306/1306 (100%), Positives = 1306/1306 (100%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQ 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQ
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQ 840
Query: 841 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 900
ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
Sbjct: 841 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 900
Query: 901 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 960
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ
Sbjct: 901 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 960
Query: 961 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1020
NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL
Sbjct: 961 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1020
Query: 1021 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1080
ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK
Sbjct: 1021 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1080
Query: 1081 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1140
ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK
Sbjct: 1081 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENK 1140
Query: 1141 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1200
WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY
Sbjct: 1141 WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1200
Query: 1201 VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD 1260
VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD
Sbjct: 1201 VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD 1260
Query: 1261 VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1261 VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2459 bits (6374), Expect = 0.0
Identities = 1306/1357 (96%), Positives = 1306/1357 (96%), Gaps = 51/1357 (3%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--------- 831
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 832 --------------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 878 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 937
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 997
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 998 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1057
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1058 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1177
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1178 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1209
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1210 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1269
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1270 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2459 bits (6374), Expect = 0.0
Identities = 1306/1357 (96%), Positives = 1306/1357 (96%), Gaps = 51/1357 (3%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--------- 831
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 832 --------------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 878 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 937
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 997
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 998 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1057
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1058 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1177
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1178 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1209
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1210 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1269
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1270 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 2403 bits (6227), Expect = 0.0
Identities = 1277/1329 (96%), Positives = 1277/1329 (96%), Gaps = 52/1329 (3%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--------- 831
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 832 --------------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 878 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 937
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 997
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 998 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1057
AVEHQRKKNN ERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNN-----------------------------ERQQQVEAVELEAKEVLKKLF 1051
Query: 1058 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
Query: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1177
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
Query: 1178 NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1237
NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ
Sbjct: 1172 NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1231
Query: 1238 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1297
SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK
Sbjct: 1232 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1291
Query: 1298 EKEHYQVLE 1306
EKEHYQVLE
Sbjct: 1292 EKEHYQVLE 1300
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 239 bits (609), Expect = 2e-62
Identities = 260/1075 (24%), Positives = 478/1075 (44%), Gaps = 182/1075 (16%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSE-----QPNKDV------VEQMEKCIQEKDEKLKTVEELLET- 753
+ L+ +K TL+ +P+ D+ E+ + +Q + ++ +++ L ET
Sbjct: 649 YTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI--LAETE 706
Query: 754 GLIQVATK--EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
G+++ K EEE R + + +E+Q + +VE+LK + D +++
Sbjct: 707 GMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVK---HLEEIVEKLKGELESSD-QVR 762
Query: 812 SVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 871
LEAEL K + +V L+ LL + Q++ K+ +++ +LA
Sbjct: 763 EHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELAL-- 820
Query: 872 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
++++ +K+HV++ +S + E + V + + +L+ EA+L++ ++
Sbjct: 821 -----VRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV--QLKTQLEWTEAILEDEQT 873
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
T ++ Q + ++E+L+ ++S E
Sbjct: 874 QRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE---------------------TEE 912
Query: 992 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1046
LK+ +E ++K +DL E L +T++ L + T K+ Q+Q+E E
Sbjct: 913 ASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-REKDTVKKLQEQLEKAE 966
Score = 234 bits (598), Expect = 3e-61
Identities = 199/715 (27%), Positives = 349/715 (48%), Gaps = 75/715 (10%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTVQLSITS 837
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V L + +
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQV-LQLQA 438
Query: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 897
+E + L+ + L+E ++L +T Q + SL+A ++ + +
Sbjct: 439 SHRESEEALQKR----------LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQ 481
Query: 898 EASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957
A S+ + E ++ K EL L L+E ++ S T+ ++ + E L Q
Sbjct: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSI--EALLEAGQARDA 539
Query: 958 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1017
+ QA + L E E ++SGL E L++AVE Q+ KNNDLREKNW+AM
Sbjct: 540 QDVQASQAEADQQQTRL----KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM 595
Query: 1018 EALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1074
EALA+ E+ ++K++ + +E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 596 EALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQD 655
Query: 1075 FEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ+S
Sbjct: 656 LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKS 715
Query: 1134 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK- 1192
VE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELEK
Sbjct: 716 VEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKH 775
Query: 1193 ---AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKA 1249
A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 776 MAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV--- 832
Query: 1250 AGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1303
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 833 -EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 239 bits (609), Expect = 2e-62
Identities = 260/1075 (24%), Positives = 478/1075 (44%), Gaps = 182/1075 (16%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSE-----QPNKDV------VEQMEKCIQEKDEKLKTVEELLET- 753
+ L+ +K TL+ +P+ D+ E+ + +Q + ++ +++ L ET
Sbjct: 649 YTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSI--LAETE 706
Query: 754 GLIQVATK--EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
G+++ K EEE R + + +E+Q + +VE+LK + D +++
Sbjct: 707 GMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVK---HLEEIVEKLKGELESSD-QVR 762
Query: 812 SVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 871
LEAEL K + +V L+ LL + Q++ K+ +++ +LA
Sbjct: 763 EHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELAL-- 820
Query: 872 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
++++ +K+HV++ +S + E + V + + +L+ EA+L++ ++
Sbjct: 821 -----VRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV--QLKTQLEWTEAILEDEQT 873
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
T ++ Q + ++E+L+ ++S E
Sbjct: 874 QRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE---------------------TEE 912
Query: 992 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1046
LK+ +E ++K +DL E L +T++ L + T K+ Q+Q+E E
Sbjct: 913 ASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-REKDTVKKLQEQLEKAE 966
Score = 234 bits (598), Expect = 3e-61
Identities = 199/715 (27%), Positives = 349/715 (48%), Gaps = 75/715 (10%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTVQLSITS 837
+KQN ++ A L +EL KV + EK ++ E+ +A K A EK V L + +
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQV-LQLQA 438
Query: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 897
+E + L+ + L+E ++L +T Q + SL+A ++ + +
Sbjct: 439 SHRESEEALQKR----------LDEVSRELCHT-------QSSHASLRADAEKAQEQQQQ 481
Query: 898 EASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957
A S+ + E ++ K EL L L+E ++ S T+ ++ + E L Q
Sbjct: 482 MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSI--EALLEAGQARDA 539
Query: 958 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1017
+ QA + L E E ++SGL E L++AVE Q+ KNNDLREKNW+AM
Sbjct: 540 QDVQASQAEADQQQTRL----KELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAM 595
Query: 1018 EALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1074
EALA+ E+ ++K++ + +E ++Q+ +E + E L L P++SV + +Y EWL
Sbjct: 596 EALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQD 655
Query: 1075 FEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
++K + +E L KL+EA+E + LQ EC++Y+S+LAETEG+L+ LQ+S
Sbjct: 656 LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKS 715
Query: 1134 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK- 1192
VE+EE W+ KV + + +++ + + E+ +E+L+ E + + +R HLE ELEK
Sbjct: 716 VEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKH 775
Query: 1193 ---AEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKA 1249
A E Y EV L+ L E+ ++L ++E QK + +L +Q L ++S +
Sbjct: 776 MAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHV--- 832
Query: 1250 AGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ-LQQLLQAVNQQLTKEKEHYQ 1303
D + SPE +E++ + + T+ + + Q Q+LT E E Q
Sbjct: 833 -EDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQ 886
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 183 bits (464), Expect = 1e-45
Identities = 227/1084 (20%), Positives = 477/1084 (44%), Gaps = 108/1084 (9%)
Query: 300 EALCVVDL---LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCK 356
EA + DL L ++ G+ A+ K ++ TL+ D + + ++ KD CK
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM------DNMTLERERESEKLKDECK 256
Query: 357 QLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME 416
+L + + S I++++ + +E V+ ++ ++ K Q + E +
Sbjct: 257 KLQSQYAS----SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL- 311
Query: 417 AEIAHLKQENGILRDAVSNTTNQLESKQ-SAELNKLRQDYARLVNELTEKTGKLQQEEVQ 475
LK+E + + + K A L++ D +L + L+ L + V+
Sbjct: 312 -----LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQ----------DLQSKFVAK 525
+A +LK +L E E +++ +++ ++ + E +Q L SK +
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 526 ENEVQSLHSKLTDTL-VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
E ++ H +L + +S ++L + Q+ + + K EE L+ +V + E L
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 585 IQQFHSQIAAQTSASVLA-------EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
QQ Q A Q S + E++ + I +KD++I+ E L ++ ++ E+E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Query: 638 KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKM 697
+D+ + E L L + ++ ++ + + + + + +E L ++ +
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606
Query: 698 EEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL------- 750
+ D+ +L++ V +L + ++E +K+ V Q++ I+ K E L + E
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNE--SKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD 664
Query: 751 ----LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
L+T + K++ELN I T+ +T ++QD + + S +E + +K
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 807 DGKIKSVEELLEAELLKV-ANKEKTVQ---------LSITSKVQELQNLLKGKEEQMNTM 856
+++ + LEA+ L+V A+KE+ +Q + + EL L+ ++E +++
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 857 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916
+ L++K + L + + L +EE + LK + ++Q + Q EEL ++
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE------TKIQHEELNNRIQTTV 838
Query: 917 NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ------NYQQASSFPP 970
EL++++ + ++LS+ L V D K KS+ E+ Q+ + ++
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
Query: 971 HEELLKVISERE-KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK---M 1026
H+ L+V E KE L L+ K+A + + N ++E+ +A L EK
Sbjct: 899 HQ--LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 1027 LQDKVNK---TSKERQQQVEAVELEAK-EVLKKLFPKVSVPSNLSYGEWLHGFEKKA--- 1079
LQ +N+ +S+++++Q+EA++ E K VL+K + + L+ EK+
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1016
Query: 1080 ------------KECMAGTSGSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1126
K+ + G E E+ LK +E +L Q + ++ + +
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
Query: 1127 LQKLQRS---VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENL--RR 1181
+Q+L+ + +EQ+ K + ++ E K ++ +Q + E+EL +S+ +IE + R+
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 1182 ERE--HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1239
E+E L EL+ ++E +T +++ K L + +L+ + + K A + K Q +
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA-DSLKAAVEQEKRNQQI 1195
Query: 1240 ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1299
Q K + IE + +E EKE + +L + A+N+ L K
Sbjct: 1196 LKDQVKKEEEELKKEFIE-KEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Query: 1300 EHYQ 1303
+ +Q
Sbjct: 1255 KEWQ 1258
Score = 169 bits (428), Expect = 2e-41
Identities = 223/1023 (21%), Positives = 439/1023 (42%), Gaps = 145/1023 (14%)
Query: 335 QEKDKLLAAVKEDAAATKDRCKQLT--QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN 392
QE L A++KE+ +++ K+L Q + ++ + + ++T + +LE++ Q
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ---ENGILRDAVSNTTNQLESKQSAELN 449
+ +QM+ F+Q Q+ EIA +K E LR+A +L + ELN
Sbjct: 150 ENF----NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL----TEELN 201
Query: 450 KLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTA 509
K L EL ++ G ++ V KK Q T + E ER E+++ +K +
Sbjct: 202 KEATVIQDLKTELLQRPG-IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 510 EH---EAAQQDLQSKFVAKENEV-------QSLHSKLTDTLVSKQQLEQRLMQLMESEQK 559
++ EA L+S+ EV Q L S + + Q L + L++ + K
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 560 ---RVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
+ N+E + +Q L Q + QQ S+++A ++ +H ++EK +
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDL---DCQQLQSRLSASETS---LHRIHVELSEKGEAT 374
Query: 617 KQTEDSLASERDRLTSKEEELKDIQNMN-------FLLKAEVQKLQA------------- 656
++ ++ L+ + + E K +Q L++E+ +L +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 657 --LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV 714
L ++ ++ +L +Q V K+ LEEQL+ +++N E L D+ K E
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQ 493
Query: 715 QKLQ--TLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Q LQ T + ++ +EQ+ + I +KD+K++ +E LL+ +
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI-------------- 539
Query: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ 832
S L KE +DL AK +++ +L++ H ++ + E L+ + + K Q
Sbjct: 540 SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ----SESHKQAQ 595
Query: 833 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 892
++ +VQE + L+ ++++ +++ + E L + + + L + +KA + +
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ---IKAKTELLL 652
Query: 893 QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 952
EA+ +Q +L+ L +N L+ + L + + L T LQD Q+ +S
Sbjct: 653 S---AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 953 QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK 1012
+++ K++ E +K + E+ ++ +L+D ++ QR+ N DL +
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA--SKEQALQD-LQQQRQLNTDLELR 766
Query: 1013 NWEAMEALASTEKMLQDKVNKTSKERQQQVEAVEL---------EAKEVLKKLFPKVSVP 1063
E + L +M ++ V+ T + Q++ EA+E E K++LK+ F +S
Sbjct: 767 ATELSKQL----EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 1064 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1123
+ + + E + + E ++VK+ KEA L E K L++
Sbjct: 823 TKIQHEELNNRIQTTVTEL-------QKVKME----KEA------LMTELSTVKDKLSKV 865
Query: 1124 EGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRER 1183
L+ + E+E K K + + KT K+++ +EN +E+
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL-------------QVQMENTLKEQ 912
Query: 1184 EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQ 1243
+ L+ LEK + E+ ++ QL + L+ + E Q++ G++++ +QS E +
Sbjct: 913 KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972
Query: 1244 SKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
+I G+ + V +TE K LQQ L Q+L EKE
Sbjct: 973 KQIEALQGELKIA----VLQKTELENK-------------LQQQLTQAAQELAAEKEKIS 1015
Query: 1304 VLE 1306
VL+
Sbjct: 1016 VLQ 1018
Score = 167 bits (424), Expect = 5e-41
Identities = 262/1310 (20%), Positives = 552/1310 (42%), Gaps = 156/1310 (11%)
Query: 90 LAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT 149
LA++ D V + V + +S++E K ++ K LE+ + +K G +
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS---- 133
Query: 150 KQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKK 209
+E + +++ + +++N + Q K + E + + +E +
Sbjct: 134 -----SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK-PDQVEGIQKSGT 268
+ TE + + +I L V K+E++ + D + ++ +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 269 KKLKTETDKENAEVKFKDFLLS-LKTMMFS--EDEALCVVDLLKEKSGVIQDALKKSSKG 325
+KLK E K ++ + +S L++ + ++ A+ V +L K KS V + K +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E L+ + Q+ KL E++ + K+ L Q+ ++ +++ R+ E
Sbjct: 309 E--NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK--------DLDCQQLQSRLSASET 358
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDA----------VSN 435
++IHV E + K ++ ++E + HLK E L+ + +
Sbjct: 359 S----LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
Query: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
NQL SK +L + + RL + + KL +E Q + + ++L+ QL+E
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
E+Q + K +H+ QQ LQ AK E Q+ ++ + K Q Q L L++
Sbjct: 475 NSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 556 SEQKRVN----KEESLQMQVQ----------DILEQNEALKAQIQQFHSQIAAQTSASVL 601
++ ++ + E L ++Q + E+N L+ Q+ Q ++ Q+ +
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 602 AEE-LHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKD-IQNMNFLLKAEVQKL-- 654
A+E LH + E+ ++ +D SL + + L S+ E K+ + ++ +KA+ + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 655 --QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-------------EISNKMEE 699
A ++A + L+ Q ++ K ++ + QL ++ + ++E
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 700 FK----ILNDQNKALKSEVQKLQT------LVSEQPNKDVVEQ------MEKCIQEKDEK 743
+K L + + L+ +++KL+ EQ +D+ +Q +E E ++
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKA-----KQNDQVSFASLVEE 798
L+ +E++ + + + K E L +I+ + + +E Q LK Q ++ L
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNL-LKGKEEQMNTMK 857
++ + E K+K +E L EL V +K V S+ + E + KGK ++ K
Sbjct: 834 IQTTVTELQ-KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 858 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 917
E K + L++ +E +SL+ + Q L+ S Q + + LK+ E
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 918 ELKRLEAMLKERESDLSSKTQLLQDVQDENK---LFKSQIE-QLKQQNYQQASSFPPHEE 973
E ++L+ + E + K + ++ +Q E K L K+++E +L+QQ Q A +E
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
Query: 974 LLKVISE------------------REKEISGLWNELDSLKD----AVEHQRKKNNDLRE 1011
+ V+ RE E+ +L S+++ A E N +
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 1012 KNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW 1071
+N + ++ L + + L+ K ++ Q++ +A++ KE K V+ S L+ E
Sbjct: 1073 QN-KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE- 1130
Query: 1072 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1131
E K ++ T +EE+K HKL+ E+ L + + L E +G L+
Sbjct: 1131 ----EIKCRQEKEITKLNEELK--SHKLESIKEITNLKDAKQLLIQQKL-ELQGKADSLK 1183
Query: 1132 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL- 1190
+VEQE+ ++ D+ K ++++ F E +L SE K+ E ++ E E +L
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 1191 -----------------EKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
+ ++ S + +L+ ++ ++ Q+ER+ +
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 1234 KAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ 1283
K + +E +Q+K+++ ++N+ + + E +++ + Q + +
Sbjct: 1301 KGEGEIEKLQTKVLEL---QRKLDNTTAAVQELGRENQSLQIKHTQALNR 1347
Score = 155 bits (393), Expect = 2e-37
Identities = 265/1237 (21%), Positives = 505/1237 (40%), Gaps = 147/1237 (11%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKK-EIQNGNLHESDSESVPRDFKLSDALAVED 94
E +A K+E + T D E+++ +K + + L + S +L LA
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 95 DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTP 154
+VA + + SSV E +K + + E + KE D +K+ K
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQT---LTENLLKKEQDYTKLEEKH------------ 325
Query: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
+E + SKK + D Q ++++ + S+ LH+ + S G+ K
Sbjct: 326 -NEESVSKKNIQATLHQKDLDCQ--QLQSRLSASETS----LHRIHVELSEKGEATQKLK 378
Query: 215 KQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTE 274
++ +E V+ H A+ + +RE + I + +K L+TE
Sbjct: 379 EELSE---VETKYQHL--------KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 275 TDKENAEVKFKDFL-LSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
A + K+ LS + +M E + V DL + S + + +K + T L HQ
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQ---VADLQLKLSRLEEQLKEKVTNS--TELQHQ 482
Query: 334 L-------QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSN---VVITRMKDRIGTL 383
L QE+ L + ++ +Q+ +++ + ++ ++ + K+ I L
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 384 EKEHNVFQNKIHVSYQET---QQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
EKE KI ET Q+Q K ++EQ+ LK ++ + A N +Q+
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ---LQEAERRW 497
+ +Q A L + L + E +L + K+ Q Q+K + L AE
Sbjct: 603 Q-EQKAHLRAAQDRVLSLETSVNELNSQLNES---KEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 498 EEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557
++ ++ + A QD Q + ++ + +KL D QLE L + E
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY 718
Query: 558 QKRVNKEESLQMQVQ----DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 613
K E L+ Q++ D LE + + +Q Q T + A EL K + +
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
+ + T L + + L S +++L + +LK Q + L+ E EL Q
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK---QDFETLSQETKIQHEELNNRIQ 835
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
+ + K+++ +E L E+S ++ ++D K KSE +K Q K + +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK-----ENQKGKAAILDL 890
Query: 734 EKCIQEKDEKLK-----TVEELLETGLIQVATKEEELN-AIRTENSSLTKEV----QDLK 783
EK +E +L+ T++E E L + KE+E + ++ E +S+ +++ LK
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKE--LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 784 AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQEL- 842
+ ++ + ELK+ +K +I++++ L+ +L+ E +Q +T QEL
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 843 ---------QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 893
QN + +E +++ +E +L T QDL+ E L +AQ
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR---QDLKSVEEKLS-----LAQ 1060
Query: 894 HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQ 953
+L S+ +Q +++E + LE ++E L + + LQD+Q E L + +
Sbjct: 1061 EDL--ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118
Query: 954 IEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1013
+ K + E+ ++ +EKEI+ L EL S K + D ++
Sbjct: 1119 LVNEKSKL----------AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168
Query: 1014 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1073
+ L L+ V + + +Q + V+ E +E LKK F
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE-LKKEF---------------- 1211
Query: 1074 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
EK+AK E+K E +K+ +E L ++ + L E G ++K +S
Sbjct: 1212 -IEKEAKL-------HSEIKEKEVGMKKHEENEAKLTMQI----TALNENLGTVKKEWQS 1259
Query: 1134 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQE----LERLRSENKDIENLRREREHLEME 1189
++ ++ + + D+ I ++++ +++ E LER +IE L+ + L+ +
Sbjct: 1260 SQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Query: 1190 LEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQ 1226
L+ E + L+ + + L + E NE Q
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 108 bits (269), Expect = 4e-23
Identities = 156/768 (20%), Positives = 327/768 (42%), Gaps = 110/768 (14%)
Query: 620 EDSLASERDRLTSKEEELKDIQN-------MNFLLKAEVQKLQALANEQA---------- 662
E +LA +RD +T +E++D+Q + LK E++K Q L ++A
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 663 AAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
A LE+ + ++ I+ ++ EQ +++ ++ + K D+ ++L+ ++ T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT--ENSSLTK 777
++E+ NK+ IQ+ LKT E L G+ VA ++EL ++T +N +L +
Sbjct: 195 RLTEELNKEAT-----VIQD----LKT-ELLQRPGIEDVAVLKKELVQVQTLMDNMTLER 244
Query: 778 EVQDLKAK------QNDQVSFASLVEELKKVIHEKDGKIK-SVEEL--LEAELLKVANKE 828
E + K K Q+ S + + +L+ + + ++ V+EL L++ + ++ K
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 829 KTVQLSITSKVQELQNLLKGKEEQ---MNTMKAVLEEKEKDLANTGKWLQ---------- 875
+T+ ++ K Q+ L + E+ ++A L +K+ D L
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
Query: 876 -DLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 934
+L E+ E+ + +E+++ K ++F++L+ +EKE +L++ + + S L
Sbjct: 365 VELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL 424
Query: 935 SKTQLLQD----VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN 990
+ L + ++++ +L ++ +QQ EE LK E+ + L +
Sbjct: 425 ETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK---EKVTNSTELQH 481
Query: 991 ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK 1050
+LD K + Q+ K EA L + + DK K Q +EA+ ++K
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI-----QNLEALLQKSK 536
Query: 1051 EVLKKL-FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL 1109
E + L + + + + GE + +E + E+V L KLK E H
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQE--KNHTLQEQVTQLTEKLKNQSESHKQA 594
Query: 1110 QLECEKYKSVLAETEGILQKLQ---RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL 1166
Q E + E + L+ Q S+E N+ +++ES + + Q+ + + L
Sbjct: 595 Q---ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
Query: 1167 ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQ 1226
+ +R L+ L+ A+ E+ ++ QL++ KL+ +Q
Sbjct: 652 LSAEAAK------TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
Query: 1227 KVAGDLHK-------AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ 1279
++ L + +Q E ++ +I K D+ ++ S + ++ ++ L
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
Query: 1280 TVTQL---------------------QQLLQAVNQQLTKEKEHYQVLE 1306
T+L + L+++ Q+LTK++E Q+L+
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813
Score = 93.2 bits (230), Expect = 1e-18
Identities = 125/636 (19%), Positives = 271/636 (42%), Gaps = 67/636 (10%)
Query: 703 LNDQNKALKSEVQKLQTL-VSEQPNKD--VVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
+ Q L S + T+ V+ + + + + Q K + DE K E + + G
Sbjct: 13 VGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGH 72
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
E L R + + L +EVQDL+A ++ ++ EELKK + + G
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYS---EELKKELEKYQG----------- 118
Query: 820 ELLKVANKEKTVQLSITSKVQELQNLLKGKEE------QMNTMKAVLEEKEKDLANTGKW 873
+ +E +T ELQ+L + EE + MK + E+K LA
Sbjct: 119 ----LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIAD 174
Query: 874 LQDLQEENESLK-AHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 932
++ +E SL+ A Q+V + + A+ ++L+ L ++ ++ + + KE
Sbjct: 175 IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPG-IEDVAVLKKELVQV 233
Query: 933 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 992
+ + + + E++ K + ++L+ Q ASS +L +++ +E++ EL
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQS---QYASSEATISQLRSELAKGPQEVAVYVQEL 290
Query: 993 DSLKDAVEHQRKKNNDL------REKNWEAMEALASTEKMLQDKVNKTSKER-------Q 1039
LK +V +KN L +E+++ +E + E + + + T ++ Q
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 1040 QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL 1099
++ A E + +L K L E L E K + A E K L+ +
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLK--EELSEVETKYQHLKA------EFKQLQQQR 402
Query: 1100 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1159
+E ++ LQ E + S L ETE L + ++++ K+ + + + +Q
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 1160 TSSEQELERLRSENKDIENL--RREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1217
+ E++L+ + + ++++ + +++H E + +++ST ++RE + L + L +
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ----ALQQST-TAKLREAQNDLEQVLRQ 517
Query: 1218 LRTEQNERQKVAGDLHKAQQSLELIQ-------SKIVKAAGDTTVIENSDVSPETESSEK 1270
+ + + Q + L K+++++ L++ +KI G+T V+ T +
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 1271 ETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
++ L +Q + ++ Q+ ++K H + +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
Score = 63.9 bits (154), Expect = 9e-10
Identities = 119/654 (18%), Positives = 250/654 (38%), Gaps = 129/654 (19%)
Query: 51 KTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSS 109
K + E K +K++ +Q+ + +++ R +LS L +E + V+ L++ + S
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 110 ---SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV----------------------- 143
S++++ K++++K +L++ S +KI +++
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSD---DQDKKVETLMVPSKRQEALPLHQET 200
E V + + S++ + K +K+++ G D +K + L + Q L ++
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 201 KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSS----------------- 243
+ + K+K +S + K E + E LI A + + +
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 244 -----------PVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK 292
V+ K E+ + L+ + Q+ +K K + N E + F
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 293 TMMFSEDEALCVVDLLK---EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAA 349
E E L LK EK + Q+ L S++ ++ +QE A +++D+A
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 350 ATK----DRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-----------------KEHN 388
+ +RCK L Q++ EK + K ++ +E K H
Sbjct: 1093 KKEQQLQERCKAL-QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 389 VFQNKIHVSYQETQQM----QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQ 444
+ K + ++ +Q+ +++ Q + ++A + K+ IL+D V K+
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK--------KE 1203
Query: 445 SAELNK-LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSY 503
EL K + A+L +E+ EK +++ E + T L L ++ W+ Q
Sbjct: 1204 EEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ-- 1261
Query: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQS----------------------------LHSK 535
+R +E E DL+ + E VQ+ L K
Sbjct: 1262 --RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Query: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFH 589
L +T + Q+L + L + +N++ + +VQ+ + + +++ H
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHH 1373
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 167 bits (422), Expect = 8e-41
Identities = 269/1240 (21%), Positives = 531/1240 (42%), Gaps = 203/1240 (16%)
Query: 182 ETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATT--YIPLMDN 239
ET+ + +KR+ A L E + K+ A++ KQ ++ + + + A + L
Sbjct: 631 ETVALDAKRESAF-LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 240 ADSS--------PVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSL 291
S+ ++D + DLL ++EG K+L E + EN ++ + LLS
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVE-ENEALREEVILLSE 748
Query: 292 KTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAV---KEDA 348
+ SE E L +++KS + + K + ++H+ LL + K+D
Sbjct: 749 LKSLPSEVERLRKE--IQDKSEELHIITSEKDK-LFSEVVHKESRVQGLLEEIGKTKDDL 805
Query: 349 AATKDRCKQLTQEMMTEK-------ERSNVVIT---RMKDRIGTLEKEHNVFQN-----K 393
A T+ K QE K ++ +V+ RM I L KE F + K
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
Query: 394 IHVSYQETQQMQMKFQQVREQMEAEIAHLKQ--ENGILRDAVSNTTNQLESKQSAELNKL 451
+SY+ TQ++Q K ++V+E++ E+ LK+ EN RD+ T + ++ + +L +
Sbjct: 866 TELSYK-TQELQEKTREVQERLN-EMEQLKEQLEN---RDSTLQTVEREKTLITEKLQQT 920
Query: 452 RQDYARLVNE---LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER-------RWEEVQ 501
++ L E L + LQ E Q K+ + + QE R + +E
Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Query: 502 SYIRKRTAEHEA-----------AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
+ ++ + +E + + + Q K V + + Q L +K T TL + + + +
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVK-DNEI 1038
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ-FHSQIAAQTSASVLAEELHK-- 607
++ + ++ LQ ++ ++ + E LK +++ I Q +L +EL K
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 608 --VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
V EK+ IK+ E L+ DRL EE+LK+ + ++ +Q +E
Sbjct: 1099 EIVAQEKNHAIKK-EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 666 HELEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS 722
+E+E ++ + K+ + +E + L +++ EE K + + K LK E+QK S
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLK-ELQK-----S 1211
Query: 723 EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDL 782
+ +D + I+E + +E L+ I + +E ++ +R S T ++ +
Sbjct: 1212 FETERD---HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 783 KAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA-------ELL--KVANKEKTV-- 831
Q+ + S L EE+ V+HE+ + +V+E+ E ELL + K+ T
Sbjct: 1269 ---QDLEKSHTKLQEEIP-VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324
Query: 832 -----QLSITSKVQELQNLLKG---KEEQMNTMKAVLEEKEKDLAN----TGKWLQDLQE 879
+L + K QE Q +K + + + T+K LE K L T +Q+ Q
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 880 ENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL 939
+ E +++E K S QF+ + L E E+ L L+E ++ S +
Sbjct: 1385 KQEQ-SLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
Query: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV------------------ISER 981
D+Q ++ +S+ +QLK+ + + EE LKV +SE+
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503
Query: 982 EKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS------ 1035
E EIS + +L+++ D +++ K ++ EK E +E +Q+KVN+
Sbjct: 1504 ETEISTIQKQLEAINDKLQN---KIQEIYEKE-EQFNIKQISE--VQEKVNELKQFKEHR 1557
Query: 1036 KERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1095
K + ++++E + E+ +L EE++++
Sbjct: 1558 KAKDSALQSIESKMLELTNRL-----------------------------QESQEEIQIM 1588
Query: 1096 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV----KVDESHKT 1151
+ +E + LQ+E ++ K T+ I+ K++ S E+E K+ + E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKE---NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 1152 IKQMQSSFTSSEQELERLRSEN-----------KDIENLRREREHLEMELEKAEMERSTY 1200
I+ ++ F + + LE + +EN +++ ++ +ER+ L E ++ER
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD-- 1703
Query: 1201 VTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD 1260
+LK L ET+T+ +Q E + V L + Q++++ ++ + + E S+
Sbjct: 1704 -----QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN-----EISN 1753
Query: 1261 VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1300
+ + E S + L ++Q+ L+ + L +++E
Sbjct: 1754 MQKDLEHSNDALKAQDL-----KIQEELRIAHMHLKEQQE 1788
Score = 167 bits (422), Expect = 8e-41
Identities = 247/1183 (20%), Positives = 497/1183 (42%), Gaps = 220/1183 (18%)
Query: 269 KKLKTETDKENAEV--------KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK 320
K + E ++ N E+ KF L +LKT + + + L +EK+ +Q+ L
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL------QEKTREVQERLN 887
Query: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI 380
E+ L QL+ +D L V+ + ++ +Q +E+ T +T+ KD +
Sbjct: 888 -----EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT--------LTQEKDDL 934
Query: 381 GTLEKEHNVFQNKIHVSYQETQQMQMKFQ-QVREQMEA-----------------EIA-- 420
L++ + ++++ +T M + Q Q+R +E+ E++
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 421 -HLKQENGILRDAVSNTTNQLESKQSAEL------------NKLRQDYARLVNELTEKTG 467
H+++ G +D ++ KQ E N++ + ++ + + EK
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
Q E EQ T LK ++ EE++ + + E Q+ ++ + KE
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE-KNHAIKKEG 1113
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE----QNEALKA 583
E+ +L + +++L+++ QL E +Q+ +N +E + + I E +NE
Sbjct: 1114 ELSRTCDRLAEV---EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK 1170
Query: 584 QIQQFHSQIAAQTSASVLAEELHKV--IAEKDKQIKQTEDSLASERDRLTS--KEEELKD 639
++ H + A L E +V I ++ K +K+ + S +ERD L +E E
Sbjct: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 640 IQNMNFLLKAEVQ---------KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ 690
+Q L A + +L+ +E+ A + +++S ++I +L E+ +
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE 1290
Query: 691 --------HEISNKMEEFKILNDQNKALKSEVQ---KLQTLVSEQPNKDVVEQMEKCIQE 739
E M E ++L +Q+ S +++ L + ++ E+++ +E
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE-- 797
+D LKT++E LE Q+ E A E+ S ++ ++K K N+ S +E
Sbjct: 1351 RDN-LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 798 --------------------------ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
E+K V EKD ++ ++E+L++E ++ K +
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD-LQRLQEVLQSESDQLKENIKEI 1468
Query: 832 QLSITSKVQELQNL---LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 888
+EL+ LK +EE +N ++ L EKE +++ K L+ + N+ L+ +
Sbjct: 1469 VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI---NDKLQNKI 1525
Query: 889 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS-------KTQLLQ 941
QE+ + +E + Q E++ EK NELK+ + K ++S L S T LQ
Sbjct: 1526 QEI--YEKEEQFNIKQISEVQ----EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Query: 942 DVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1001
+ Q+E ++ + E++K+ +E L++ E D LK+ +
Sbjct: 1580 ESQEEIQIMIKEKEEMKRV-----------QEALQI-------------ERDQLKENTKE 1615
Query: 1002 QRKKNNDLREKNWEAMEALA---STEKMLQDKVNKTSKERQQ-QVEAVELEAKEVLKKLF 1057
K + +EK ++ ++ A + EKM + + K E Q+ +E +E E + + L
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
Query: 1058 PKVSVPSNL--------SYGEWLHGFEKKAKECMAGT-----SGSEEVKVLEHKLKEADE 1104
+ ++ S E L + KE + T EE+K++ LKE E
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Query: 1105 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK---VKVDE----SHKTIKQMQS 1157
+K + +++E + +Q+ +E + K +K+ E +H +K+ Q
Sbjct: 1736 T-------IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQE 1788
Query: 1158 SFTSSE----QELERLRSENKDIENLR----------REREHLEMELEKAEMERSTYVTE 1203
+ ++ ++L + KD+EN + EH + L+K E V+E
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
Query: 1204 VRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP 1263
+ +LK Q+ + L + E +A LH ++LE ++S ++K + +E
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLH---ENLEEMKS-VMKERDNLRRVE------ 1898
Query: 1264 ETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
ET E++ + SL +T + ++ Q + KEH + ++
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Score = 154 bits (388), Expect = 7e-37
Identities = 286/1425 (20%), Positives = 596/1425 (41%), Gaps = 254/1425 (17%)
Query: 30 KETLYDEVLAKQKREQKLIP----TKTDKKKAEKK-KNKKKEIQN-GNLHES-------- 75
K+ L+ EV+ K+ R Q L+ TK D + K+ +E QN LH
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV 836
Query: 76 --DSESVPRDF--------KLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVL 125
++E + ++ K +L +++ + E + V+ER + ++ K L
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 126 EEQ------VIKESD--ASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ 177
E + V +E K+ E +T++ + S + + + D
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956
Query: 178 DKKVETLMVPSKRQEALPLHQET----------------KQESGSGKKKASSKKQKTENV 221
+ ++T E+L HQET E +G+ K +QK +
Sbjct: 957 NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK-DEFQQKMVGI 1015
Query: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTETD-KE 278
+ L T D D+ + +R++ L+ K + + ++ +K + +TD KE
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 279 NAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD----ALKKSSKGELTTLIHQL 334
N E+ ++ ++E + D LK++ ++ A+KK +GEL+ +L
Sbjct: 1076 NIEMTIEN-----------QEELRLLGDELKKQQEIVAQEKNHAIKK--EGELSRTCDRL 1122
Query: 335 QEKDKLLAAVKEDAAATKDRCKQL--TQEMMTEKERSNVVITRMKDRIGT-------LEK 385
E ++ L KE + +++ +QL QE M+E ++ I +K+ + +E
Sbjct: 1123 AEVEEKL---KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 386 EHNVFQNKIHVSYQETQQMQMK---FQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442
E K++ +Y+E + + + +++++ E E HL+ G +R+ + E
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR---GYIREIEATGLQTKEE 1236
Query: 443 KQSAELN-----KLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKV 488
+ A ++ + + R V+E T EK+ QEE+ + EQ
Sbjct: 1237 LKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
Query: 489 QLQEAERRWEEVQSYIRKRT-------AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
++ E + E++ + T A E + L KF + E++SL + +
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356
Query: 542 SKQQLEQRLMQLMES--------EQKRVNKEESLQMQVQDILEQNEALK--AQIQQFHSQ 591
K+ LE + QL E ++ + +E+SL M+ +D NE K ++++QF +
Sbjct: 1357 IKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD----NETTKIVSEMEQFKPK 1412
Query: 592 IAA-------QTSASVLAEELH---KVIAEKDKQIKQTEDSLASERDRLTSK-------- 633
+A S +E H K +A++ +++ ++ L SE D+L
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 634 ---EEELK-----------DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
EEELK I + L + ++ + + A +L+ Q +Y K+
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK--DVVEQMEKCI 737
++ + + E+ K+ E K + KA S +Q +++ + E N+ + E+++ I
Sbjct: 1533 EQFNIKQIS---EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTE--------------NSSLTK--EVQD 781
+EK+E +K V+E L+ Q+ +E+ A E N + K E++
Sbjct: 1590 KEKEE-MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 782 LKAK-----------QNDQVSFASLV----EELKKVIHEKDGKIKSVEELLEAELLKVAN 826
LK + + + + ++ EE++ V E+D ++SVEE L+ E ++
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD-LRSVEETLKVERDQLKE 1707
Query: 827 KEKTVQLSITSKVQELQNL---LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 883
+ K +EL+ + LK +E ++ ++ ++ EK +++N K DL+ N++
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK---DLEHSNDA 1764
Query: 884 LKAH---VQE---VAQHNLKE-------------------ASSASQFEELEIVLKEKENE 918
LKA +QE +A +LKE ++ E L+EK E
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 919 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQ---IEQLKQQNYQQASSFPPH-EEL 974
LK E L + D++ + + +++ K K Q + +L+ +N A + EE+
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 975 LKVISERE---KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1031
V+ ER+ + L E D LK++++ + ++ +++++ + L+ K DK+
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE-LKTARMLSKEHKETVDKL 1943
Query: 1032 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1091
+ E+ Q+ ++ + + +L K+ E + KE E+
Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKKIQ--------------ELQKKELQL-LRVKED 1988
Query: 1092 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE--NKWKVKVDESH 1149
V + K+ E +++ + + +SV + + +KL S+E+ K + ++
Sbjct: 1989 VNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIK 2048
Query: 1150 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKA 1209
+++K + F ++ +E+ +N ++ +R + L ++ E+ + + E+ + +
Sbjct: 2049 ESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYS 2108
Query: 1210 QLN---ETLTKLRTE---QNERQKVAGDLHKAQQSLELIQSKIVK 1248
+++ E L +L + + E QK KA SL +Q+K ++
Sbjct: 2109 EMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIE 2153
Score = 148 bits (374), Expect = 3e-35
Identities = 267/1413 (18%), Positives = 595/1413 (42%), Gaps = 229/1413 (16%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKK----KNKKKEIQNGNL--HESDSESVPR 82
++E L ++ Q+++Q+L+ + + + +KK +N K E++N L ++E +
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 83 DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ-----VIKESDASK 137
KL++ N E S +ERK ++ QK E+ I+E +A+
Sbjct: 1185 AQKLNE--------------NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH 197
+ K+ + ++ +K ++ + +K T K QE +P+
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT-----KLQEEIPVL 1285
Query: 198 QETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKP 257
E ++ + K+ + +++ E + E +TT D+ + + +R ++
Sbjct: 1286 HEEQELLPNVKEVSETQETMNELELLTE---QSTT----KDSTTLARIEMERLRLNEKFQ 1338
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVK-------FKDFLLSLKTMMFSEDEALCVVDLLKE 310
+ E I+ ++ +T KE EVK ++ L ++ ++++L + + E
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 311 KSGVIQDALKKSSKG--------ELTTLIHQLQEK-DKLLAAVKEDAAATKDRCKQLTQE 361
+ ++ + + K E+ L +LQE D++ + KE KD ++L +
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-----KDDLQRLQEV 1453
Query: 362 MMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVR---EQMEAE 418
+ +E ++ +K+ I + +H + ++ V++ ++ + ++R + E E
Sbjct: 1454 LQSESDQ-------LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
I+ ++++ + D + N ++ K+ Q + ++E+ EK +L+Q + +K
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEE-------QFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
+ A ++ ++ E R +E Q I+ E E ++ +Q + ++++ ++
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-VQEALQIERDQLKENTKEIVA 1618
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
+ Q+ E + +++ VN+ + +++ + EQ E K ++ ++ T
Sbjct: 1619 KMKESQEKEYQFLKMTA-----VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 599 -SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS-----------KEEELKDIQNMNFL 646
EE+ V E+D ++ E++L ERD+L K+EELK +
Sbjct: 1674 LHENLEEMRSVTKERD-DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
Query: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
+ + KL+ + +E+ +E+ MQ+ + +D ++ + ++Q EE +I +
Sbjct: 1733 HQETIDKLRGIVSEKT---NEISNMQKDLEHSNDALKAQDLKIQ-------EELRIAHMH 1782
Query: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELN 766
K + + KL+ +VSE+ +K + M+K ++ + KL+ + L+ Q+ T ++++N
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDK--LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840
Query: 767 AIR---TENSSLTKEVQD----LKAKQNDQVSFASLV----EELKKVIHEKDGKIKSVEE 815
+ +E L K+++D L + + ++ A + EE+K V+ E+D ++ VEE
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN-LRRVEE 1899
Query: 816 LLEAE---LLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
L+ E L + + K L I +++ + L K +E ++ ++ + EK +++ K
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Query: 873 WLQDLQEENESLKAHVQEVAQHNLK-------------------------EASSASQ--- 904
DL + + L+ +QE+ + L+ EA + S
Sbjct: 1960 ---DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV 2016
Query: 905 --------------FEELEIVLKEKENELKRLEAMLK-ERESDLSSKTQLL------QDV 943
EE+ IV KE++ EL+R++ LK ER+ +++ +++ V
Sbjct: 2017 RMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIARDRQNHQV 2075
Query: 944 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1003
+ E +L + L + ++ S +ELLK SE + L L+ +E Q+
Sbjct: 2076 KPEKRLLSDGQQHLTESLREKCSRI---KELLKRYSEMDDHYECLNRLSLDLEKEIEFQK 2132
Query: 1004 ------KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQ---QQVEAVELEAKEVLK 1054
K N L + +E L + + + ++ K+ + V ++ E E +
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192
Query: 1055 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV-------LEHKLKEADE--- 1104
K F + E L + ++C + ++K+ +E LK+ E
Sbjct: 2193 K-FEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEF 2251
Query: 1105 --MHTLLQL------ECEKYKSVLAETEGILQKLQRSVEQEENK-WKVKVDESHKTIKQM 1155
+ T Q E ++ T ++KL+ +++E ++ +V +++ I M
Sbjct: 2252 PSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIM 2311
Query: 1156 QSSFTSSEQELERLRSENKDIENLRREREHLEMELE--KAEMERSTYVTEVRELKAQLNE 1213
S E+ + +D+++L+ + E L + K + V + +
Sbjct: 2312 NESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV 2371
Query: 1214 TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM 1273
T + + +++ LH+A++S +SKI+K + V
Sbjct: 2372 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEV------------------ 2413
Query: 1274 SVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
N + +LQ + N+ L K KE QVL+
Sbjct: 2414 ---TNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Score = 125 bits (313), Expect = 3e-28
Identities = 224/1079 (20%), Positives = 449/1079 (41%), Gaps = 170/1079 (15%)
Query: 239 NADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSE 298
N + S V ++DL ++ +G + KE + F+L S+
Sbjct: 221 NCEGSVKVSHLNLVDLAGSERAAQTGAAGVRL------KEGCNINRSLFILGQVIKKLSD 274
Query: 299 DEALCVVDLLKEK-SGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
+ ++ K + ++Q++L ++K + I + D+ L A++ + A +
Sbjct: 275 GQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSF-DETLTALQFASTAKYMKNTP 333
Query: 358 LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA 417
E+ T++ ++ R + I L+K+ + E Q+ ++ + +
Sbjct: 334 YVNEVSTDE----ALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEE--KDLLQ 387
Query: 418 EIAHLKQENGILRDAVSNTTNQLESKQSAE-----------LNKLRQ----DYARLVNEL 462
++ + K EN + R V++++ L+ + A+ +NK++ D + +
Sbjct: 388 KVQNEKIEN-LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNI 446
Query: 463 TEKTGKLQ---QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
T KT KL E+ + ++ +E W + + E E L
Sbjct: 447 TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESE-----LN 501
Query: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
S +N V T+ K+++E +L + + ++ + ++ + Q ++ +
Sbjct: 502 SLRADYDNLVLDYEQLRTE----KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEIS 557
Query: 580 ALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR-----LTSKE 634
LK ++ H+++ Q + L+ ++ +++ EK+ QIK+ ++ + S++ L+
Sbjct: 558 NLKNLVK--HAEVYNQDLENELSSKV-ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
Query: 635 EELKDIQNMN-FLLKAEVQKLQA------LANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687
E ++D + M L AE L A L +E +++++ + ++ I+L +
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 688 QLQHEISNKMEEFKILNDQNKALKS---EVQKLQTLVSEQPNKDVVEQME---KCIQEKD 741
QL E KM+ D K L+S E+ KL +L+ + KD++ +E K +
Sbjct: 675 QL--EAKKKMQV-----DLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
E K VEE L + EL ++ +E L KE+QD + + + E K
Sbjct: 728 ELNKEVEE--NEALREEVILLSELKSLPSEVERLRKEIQDKSEELH------IITSEKDK 779
Query: 802 VIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLE 861
+ E K V+ LLE E+ K + T Q + S QE QN + K VLE
Sbjct: 780 LFSEVVHKESRVQGLLE-EIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLE 838
Query: 862 EKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENE 918
E E+ ++ N K Q +LK + Q + +E ++E+ NE
Sbjct: 839 ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ----------ELQEKTREVQERLNE 888
Query: 919 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 978
+++L+ L+ R+S LQ V+ E K+ I + QQ ++ + ++ LK +
Sbjct: 889 MEQLKEQLENRDS-------TLQTVERE----KTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 979 SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE- 1037
E L E D LK + N D +E+ A+E+L ++ + +K S+E
Sbjct: 938 QE------SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
Query: 1038 -RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLE 1096
R +E E K+ ++ + +L +AK T+ ++ +++E
Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDL-----------EAKNTQTLTADVKDNEIIE 1040
Query: 1097 HK------LKEADEMHTLLQ---LECEKYKSVLAETEGI--------------LQKLQRS 1133
+ ++E +E+ +L+ E E+ K+ L E + L+K Q
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 1134 VEQEEN-----------------KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI 1176
V QE+N + + K+ E + +++ Q + ++E+ ++ + +I
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 1177 ENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKA 1235
ENL+ E ++ E+ LE E ER EL +LNE ++++ ER KV +L K+
Sbjct: 1161 ENLKNELKNKELTLEHMETER-------LELAQKLNENYEEVKSITKER-KVLKELQKS 1211
Score = 111 bits (278), Expect = 4e-24
Identities = 219/1153 (18%), Positives = 476/1153 (41%), Gaps = 210/1153 (18%)
Query: 57 AEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKK 116
A+ ++++ K+ Q+ N+ E D+E+ ++ + +D + + + ++ S ++E
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSEM-EQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 117 ------KEKKQKPVLEEQVIKESDASKIPGKKV--------EPVPVTKQPTPPSEAAASK 162
KEK L+E + ESD K K++ E + V E ++
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 163 KKPGQKKSKNGSDDQDKKVETL--MVPSKRQEALPLHQETK-QESGSGKKKASSKKQKTE 219
+ + + K++E + + +K QE ++ ++ ++K + KQ E
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 220 N--------VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQ-KSGTKK 270
+ ++ ++ T + + +K E+ + + Q+E Q K TK+
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK--KSSKGELT 328
+ + KE+ E K++ T + E +C ++ LKE+ + L+ ++ LT
Sbjct: 1616 IVAKM-KESQE---KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671
Query: 329 TLIHQ--------LQEKDKLLAAVKEDAAATKDRCKQLTQEMMT----EKERSNVVITRM 376
++H+ +E+D L +V+E +D+ K+ +E +T ++E +V +
Sbjct: 1672 QILHENLEEMRSVTKERDDL-RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 377 KDRIGTLEKEHNVFQNKIHVSYQETQQMQ-----MKFQQVREQMEAEIAHL---KQENGI 428
K+ T++K + K + + ++ +K Q ++ Q E IAH+ +Q+ I
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
Query: 429 --LRDAVSNTTNQLESKQSAELN---KLRQDYARL-------------VNELTEKTGKLQ 470
LR VS T++L + Q N KL++ L VNE +K +++
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 471 QEEVQKKNAEQAATQLKVQ----LQEAERRWEEVQSYIRKRT----------AEHEAAQQ 516
Q + Q K+ ++L+++ Q+ EE++S +++R E + ++
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910
Query: 517 DLQ---------------SKFVAKENE--VQSLHSKLTDTLV-----------SKQQLEQ 548
LQ ++ ++KE++ V L K+++ + SK +L++
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970
Query: 549 RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH-- 606
++ +L + E + + +E + M + I E + K Q S + + L ++LH
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 607 ----KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL----QALA 658
+++A++ ++++ ++SL ERD+ + E+ N +K E + L Q L
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 659 NEQAAAAHELEKMQQSVYVKDDKIRLL---------EEQLQHEISNKME----------- 698
++++ + DD L E + Q E+S +++
Sbjct: 2091 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTK 2150
Query: 699 --------------EFKILNDQNKALKSEVQKLQTLVSEQPNK---DVVEQMEK------ 735
EF + + K + S V K++ E NK D ++++EK
Sbjct: 2151 HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLI 2210
Query: 736 ----CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Q+ D + + +L + + +E + +E S+ E Q + + + +
Sbjct: 2211 KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270
Query: 792 FASL-------VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---LSITSKVQE 841
F +E+LK I +++ +I V ++ + N+ + +I+ + ++
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQ 2330
Query: 842 LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA------HVQEVAQHN 895
LK K E++ L+ A QD + + + +A ++E+ +++
Sbjct: 2331 DLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL-ENS 2389
Query: 896 LKEASSASQFEELEIVLKEKENE-----LKRLEAMLKERESDLSSKTQLLQDVQDENKL- 949
L EA ++ +E +I+ +KE E + +L+A + E L + +Q +QD+ L
Sbjct: 2390 LHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALG 2449
Query: 950 ---FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1006
+K +IE LK + L+K+ E+ K E+ + K VE+Q++
Sbjct: 2450 AKPYKEEIEDLKMK-------------LVKIDLEKMKNAKEFEKEISATKATVEYQKEVI 2496
Query: 1007 NDLREKNWEAMEA 1019
LRE + +A
Sbjct: 2497 RLLRENLRRSQQA 2509
Score = 57.4 bits (137), Expect = 9e-08
Identities = 143/711 (20%), Positives = 290/711 (40%), Gaps = 95/711 (13%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNK----KKEIQNGNLHESDSESVPRD-F 84
K+ L ++ QK+E +L+ K D + KK N+ KK+ + NL +SV D F
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL---SMQSVRMDNF 2021
Query: 85 KLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQK-PVLEEQVIKESDASKIPGKKV 143
+L+ L +++ V E ++E K E+ Q L E + ++ ++ +K
Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRR-IKESLKMERDQFIATLREMIARDRQNHQVKPEKR 2080
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSD----------DQDKKVETLMVPSKRQEA 193
+ T S+ K K+ D D +K++E S R +A
Sbjct: 2081 LLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKA 2140
Query: 194 ---LPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE 250
LP Q E K ++++ E + + L + +Y+ + ++ E
Sbjct: 2141 NLSLPYLQTKHIE----KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE-------EQHE 2189
Query: 251 VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKE 310
I+ + D ++ ++K +K + +++ +V ++ L+ + +++ L + ++LK+
Sbjct: 2190 SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE----LRDLKLNQNMDLHIEEILKD 2245
Query: 311 KSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSN 370
S +S + T Q+ K + E+ T+ ++L + E +R
Sbjct: 2246 FS--------ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297
Query: 371 VVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILR 430
V +N F N+I E+ + + + + ++ E ++ LK++N L
Sbjct: 2298 QV--------------NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343
Query: 431 DAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQL 490
L S A++N QD +T + +L E+++ +L+ L
Sbjct: 2344 KNYQTLKTSLAS--GAQVNPTTQDNKN--PHVTSRATQLTTEKIR---------ELENSL 2390
Query: 491 QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
EA+ +S I K E E D+ +K AK +E K +T+ ++
Sbjct: 2391 HEAKESAMHKESKIIKMQKELEVT-NDIIAKLQAKVHESNKCLEKTKETI--------QV 2441
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610
+Q + + KEE ++++ + E +K ++F +I+A + +E+ +++
Sbjct: 2442 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMK-NAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 611 EKDKQIKQTED-SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
E ++ +Q +D S+ SE T + K + + K L +E E+
Sbjct: 2501 ENLRRSQQAQDTSVISEH---TDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
Query: 670 KM-QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
K+ QQ+ + K LL QH +SN+++ +K + LK E K T
Sbjct: 2558 KLKQQNEQLIKQKNELLSNN-QH-LSNEVKTWK-----ERTLKREAHKQVT 2601
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 166 bits (420), Expect = 1e-40
Identities = 251/1134 (22%), Positives = 493/1134 (43%), Gaps = 172/1134 (15%)
Query: 261 EGIQKSGTKKLKTE---TDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
E + K K+L E T+ E + + L L+ + +E E + L+
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR-------- 903
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A + K EL + H L+ A V+E+ ++RC Q + EK++ I ++
Sbjct: 904 ARLTAKKQELEEICHDLE------ARVEEE----EERC----QHLQAEKKKMQQNIQELE 949
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT 437
++ LE+E + Q K+ + T+ K ++ + +E + L +E +L D ++ T
Sbjct: 950 EQ---LEEEESARQ-KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 438 NQL--ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA-------ATQLKV 488
L E ++S L KL+ + ++ +L E+ L++EE Q++ E+ +T L
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEER---LRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 489 QLQEAERRWEEVQSYIRKRTAEHEAA----------------------------QQDLQS 520
Q+ E + + E++ + K+ E +AA Q+DL+S
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 521 KFVAKENEVQSLHSKLTDTLVS-KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
+ A N+ + L + L + K +LE L ++ R +E+ + + + + E+ +
Sbjct: 1123 E-RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 580 ALKAQIQ---QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEE 636
+AQIQ Q HSQ + LAE+L + K +++ + +L +ER L ++ +
Sbjct: 1182 THEAQIQEMRQKHSQAVEE-----LAEQLEQTKRVK-ANLEKAKQTLENERGELANEVKV 1235
Query: 637 L----KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE 692
L D ++ ++A++Q+LQ NE EL + V+ D + L Q +
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 693 ISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLE 752
S ++F AL+S++Q Q L+ E+ N+ + K Q +DEK E+L E
Sbjct: 1296 SSKLTKDF-------SALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 753 TGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
+EE + + + ++L +V D+K K D V EE+K+ + K
Sbjct: 1348 --------EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ------KD 1393
Query: 813 VEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
+E L + KVA +K ++ + T QEL +LL + Q + LE+K+K K
Sbjct: 1394 LEGLSQRHEEKVAAYDK-LEKTKTRLQQELDDLLVDLDHQRQS-ACNLEKKQK------K 1445
Query: 873 WLQDLQEENESLKAHVQE----VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK- 927
+ Q L EE + +E A+ KE + S LE +++K EL+RL +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA-ELERLNKQFRT 1504
Query: 928 ERESDLSSKTQL---LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE--------LLK 976
E E +SSK + + +++ + + Q+E++K Q + E+ L
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 977 VISEREKEISGLWNELDSLKDAVEHQ-RKKNNDLREKNWEAMEALASTEKMLQ------- 1028
+ ++ E+++ G + + K + Q R+ +L ++ + A+A+ +K+
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 1029 --DKVNKTSKERQQQVEAVELEAKEVLKKL-FPKVSVPSNLSYGEWLHGFEKKAKECMAG 1085
D NK E +Q+ ++ + K+ +++L + S L+ + EKK K A
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK---ENEKKLKSMEAE 1681
Query: 1086 -TSGSEEVKVLEHKLKEADEMHTLL--QLECEKYKSVLA-----ETEGILQKLQRSVEQE 1137
EE+ E ++A + L ++ K LA E + +L+ +E+E
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 1138 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME- 1196
+ ++ D K +Q +++ LER ++ + + ER++ E++++ EME
Sbjct: 1742 QGNTELINDRLKKA--NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEG 1799
Query: 1197 --RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE--LIQSKIVKAAGD 1252
+S Y + L+A++ + +L E ERQ + + ++ L+ L+Q
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ--------- 1850
Query: 1253 TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+++ + E + + S L Q QL++ + + ++ + LE
Sbjct: 1851 ---VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Score = 139 bits (350), Expect = 2e-32
Identities = 173/801 (21%), Positives = 339/801 (42%), Gaps = 102/801 (12%)
Query: 550 LMQLMESEQKRVNKEESL------QMQVQDILEQNEALKAQIQ----QFHSQIAAQTSAS 599
L+Q+ E++ + KEE L Q+ ++ L + E L++Q+ Q Q+ A+T
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
AEEL + K +++++ L + R+ +EE + +Q ++ +Q+L+
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
E+ +A +K+Q + K++ LE EE IL DQN L E + L+
Sbjct: 954 EEESAR---QKLQLEKVTTEAKLKKLE-----------EEQIILEDQNCKLAKEKKLLE- 998
Query: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV 779
D + + + E++EK K++ +L + EE L + L K
Sbjct: 999 --------DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR 1050
Query: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKV 839
+ L + D + + EL+ I E ++ EE L+A L +V + +++ K+
Sbjct: 1051 RKL---EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL-KKI 1106
Query: 840 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 899
+EL++ + +E + + +A + EK +DL EE E+LK +++ +
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQ-------KRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 900 SSASQFE-ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958
S+ E E+ I+ K E E K EA ++E S + L + ++ K K+ +E+ K
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 959 QQNYQQASSFPPHEELL-----------------------------KVISEREKEISGLW 989
Q + ++L +V +E +++ L
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 990 NELDSLKDAVEHQRKKNNDLREKNWEAMEA-LASTEKMLQDKVNKTSKERQQQVEAVELE 1048
ELD++ + K++ L K++ A+E+ L T+++LQ++ N+ +++ VE E
Sbjct: 1280 VELDNVTGLLSQSDSKSSKL-TKDFSALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDE 1337
Query: 1049 AKEVLKKLFPKVSVPSNLSYG-EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT 1107
++L + NL LH K+ M + G L+ A+E+
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC---------LETAEEVKR 1388
Query: 1108 LLQLECEKYKSVLAETEGILQKLQRS---VEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
LQ + E E KL+++ ++QE + V +D +Q + ++
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ----RQSACNLEKKQK 1444
Query: 1165 ELERLRSENKDIE-NLRREREHLEMELEKAE---MERSTYVTEVRELKAQLNETLTKLRT 1220
+ ++L +E K I ER+ E E + E + + + E E KA+L + RT
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 1221 EQNERQKVAGDLHKAQQSLELIQSKIVKAAGD-TTVIENSDVSPETESSEKETMSVSLNQ 1279
E + D+ K+ LE + + + + T +E + + K + V+L
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 1280 TVTQLQQLLQAVNQQLTKEKE 1300
Q ++ LQ ++Q ++K+
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKK 1585
Score = 133 bits (335), Expect = 1e-30
Identities = 231/1087 (21%), Positives = 456/1087 (41%), Gaps = 169/1087 (15%)
Query: 105 VETSSSVRERKKKEK-----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEA 158
+E S R++ + EK K K + EEQ+I E K+ KK+ + + T +E
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 159 AASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGS-----GKKKASS 213
K + K+K+ + D + +RQE ++ + +S + +A
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 214 KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273
+ K + +E L A + + A + + K ++ + E ++ + K
Sbjct: 1072 AELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
E K + + L +LKT + ++ L+ K + LKK+ + E T Q
Sbjct: 1131 EKQKRD----LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
+QE + + Q +E+ + E++ V ++ TLE E N+
Sbjct: 1187 IQE--------------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 394 IHVSYQ--------------ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQ 439
+ V Q + Q++Q+KF + E++ E+A + + D V+ +Q
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNE-GERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
+SK S KL +D++ L ++L + LQ+E QK + +T+LK + E+
Sbjct: 1292 SDSKSS----KLTKDFSALESQLQDTQELLQEENRQKLS---LSTKLK--------QVED 1336
Query: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL-------VSKQQLEQRLMQ 552
++ R++ E E A+ +L+ + +V + K+ D++ K++L++ L
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 553 LMESEQKRV-------NKEESLQMQVQDIL------EQNEALKAQIQQFHSQIAAQ--TS 597
L + +++V + LQ ++ D+L Q+ + Q+ Q+ A+ T
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
++ AEE + AE ++ E S L E+ +++ +N + E++ L +
Sbjct: 1457 SAKYAEERDRAEAE----AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL 717
++ + HELEK + R LE+Q++ E+ ++EE L D+ +A +E KL
Sbjct: 1513 KDDVGKSVHELEKSK----------RALEQQVE-EMKTQLEE---LEDELQA--TEDAKL 1556
Query: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK 777
+ V+ Q K Q E+ +Q +DE+ EE + + QV E EL R + S
Sbjct: 1557 RLEVNLQAMK---AQFERDLQGRDEQ---SEEKKKQLVRQVREMEAELEDERKQRS---- 1606
Query: 778 EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSIT- 836
+ A++ ++ L + +D IK + + L+A++ K+ +L T
Sbjct: 1607 --MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK-LQAQM-----KDCMRELDDTR 1658
Query: 837 SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 896
+ +E+ K E+++ +M+A + + +++LA + + Q+E + L E+A +
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL---ADEIANSSG 1715
Query: 897 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 956
K A + L+EK +RLEA + + E +L + + + D K QI+Q
Sbjct: 1716 KGA----------LALEEK----RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761
Query: 957 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1016
+ + S +E + + + KE+ E++ ++ K +
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEME-------------GTVKSKYKAS 1808
Query: 1017 MEALASTEKMLQDKVNKTSKERQ---QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1073
+ AL + L+++++ +KERQ +QV E + K+VL + V E
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL------LQVDDERRNAEQYK 1862
Query: 1074 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
KA S +K L+ +L+EA+E K + L + + R
Sbjct: 1863 DQADKA---------STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNRE 1913
Query: 1134 VEQEENK 1140
V +NK
Sbjct: 1914 VSSLKNK 1920
Score = 79.0 bits (193), Expect = 3e-14
Identities = 116/540 (21%), Positives = 221/540 (40%), Gaps = 85/540 (15%)
Query: 837 SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 896
+KV+ L + + +EE M + +++ +EK LA + L +++ L A ++ +
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENR-LTEMETLQSQLMAEKLQLQEQLQ 890
Query: 897 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 956
E ++ EEL L K+ E LE + + E+ + + + Q +Q E K + I++
Sbjct: 891 AETELCAEAEELRARLTAKKQE---LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQE 947
Query: 957 LKQQNYQQASSFP-------PHEELLKVISER----EKEISGLWNELDSLKDAVEHQRKK 1005
L++Q ++ S+ E LK + E E + L E L+D +
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 1006 NNDLREKNWEAMEALASTEKM---LQDKVNKTSKERQQ------QVEAVELEAKEVLKKL 1056
+ EK+ + E M L++++ + K+RQ+ ++E + + + +L
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 1057 FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE-----------VKVLEHKLKE---- 1101
+++ E KK +E A + EE ++ LE ++ E
Sbjct: 1068 QAQIA--------ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 1102 ----------ADEMHTLLQLECEKYKSVLAET---EGILQKLQRSVEQEENKWKVKVDES 1148
A++ L E E K+ L +T Q+L+ EQE N K ++E
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 1149 HKTIK-QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEV--- 1204
KT + Q+Q Q +E L + +E +R + +LE + E ER EV
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQ---LEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 1205 -----------RELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELI-------QSKI 1246
++++AQL E K + R ++A + K Q L+ + SK
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 1247 VKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
K D + +E+ + E+ +SL+ + Q++ + +QL +E+E LE
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Score = 71.6 bits (174), Expect = 5e-12
Identities = 125/700 (17%), Positives = 279/700 (39%), Gaps = 88/700 (12%)
Query: 57 AEKKKNKKKEIQN--GNLHESDSES--VPRDFKLSDA--------LAVEDDQVAPVPLN- 103
A+K + E+ N G L +SDS+S + +DF ++ L E+ Q +
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 104 --VVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAAS 161
V + +S RE+ ++E++ K LE+Q+ KK+E + +
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 162 KKKPG---QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKT 218
K G + + K + D+ +K +T + + + L + + +++S +K K++K
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRL--QQELDDLLVDLDHQRQSACNLEK---KQKKF 1446
Query: 219 ENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKL------- 271
+ + +E I A Y D A++ + + + L + + QK+ ++L
Sbjct: 1447 DQLLAEEKTISAK-YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 272 ------------KTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL 319
K+ + E ++ + + +KT + ++ L + K + V A+
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 320 KKSSKGELTTLIHQLQEKDK-LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
K + +L Q +EK K L+ V+E A +D KQ + + K + + + ++
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK-KLEMDLKDLEA 1624
Query: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
I + K + ++ + + + R E +A K+ L+ +
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 439 QLESKQSAELNK--LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496
E +AE K +Q+ L +E+ +GK +K+ E QL+ +L+E +
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 497 WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
E + ++K + + DL
Sbjct: 1745 TELINDRLKKANLQIDQINTDL------------------------------------NL 1768
Query: 557 EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
E+ K E+ + Q++ QN+ LK ++Q+ + ++ AS+ A L IA+ ++Q+
Sbjct: 1769 ERSHAQKNENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA--LEAKIAQLEEQL 1823
Query: 617 KQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVY 676
+ ++ E++LKD+ + ++ + A++ + +L++ +
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883
Query: 677 VKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+ + +LQ E+ + E +N + +LK+++++
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 166 bits (419), Expect = 2e-40
Identities = 236/1173 (20%), Positives = 507/1173 (43%), Gaps = 160/1173 (13%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++R++ + +E +K+ +++++ E V L+ + L
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVS--LLQEKNDLQLQVQ 892
Query: 240 ADSSPVVDKREVIDLLKPD--QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+ + D E D L + Q+E K ++L+ E ++ NAE+ K +D LK
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELK 951
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+++A + ++ A +
Sbjct: 952 RDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E V + K+ +
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
TQ+ M + ++Q++ + E L + + E ++L K ++ +
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIED-----EQALGSQLQKKLKELQARI 1115
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
EL E+ L+ E + E+ + L +L+E R EE +KR AE +
Sbjct: 1116 EELEEE---LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++++
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 573 DI---LEQNEALKAQIQQF----------HSQIAAQTSASV--LAEELHKVIAEKDKQIK 617
D+ +EQ KA +++ H A +T SV L + K+ E + +
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
Q ++ A K + ++++ L+ EV+ ALA+ +A H+ +
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD-------- 1341
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
LL EQ + E K E ++L+ N + K +T ++ E++E+
Sbjct: 1342 ------LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-----TEELEEAK 1390
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFA 793
++ ++L+ EE +E + ++ E+ + ++ E L +V+ A Q +F
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450
Query: 794 SLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQLSITSKVQELQNLLKGKE 850
++ E K+ E +++S ++ L EL K+ N + + L++L K
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE----------ESLEHLETFKR 1500
Query: 851 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 910
E N + + + E+ L ++GK + +L++ + L+A E+ Q L+EA ++ + EE +I
Sbjct: 1501 ENKNLQEEISDLTEQ-LGSSGKTIHELEKVRKQLEAEKMEL-QSALEEAEASLEHEEGKI 1558
Query: 911 VLKEKE-NELK-RLEAMLKERESDL------------SSKTQLLQDVQDENKLF--KSQI 954
+ + E N++K +E L E++ ++ S +T L + + N+ K ++
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618
Query: 955 E--------QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1006
E QL N A + + L ++ + + ++ D LK+ + ++N
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 1007 NDLREKNWEAMEALASTE---KMLQDKVNKTSKERQQQVEAVELEAKEVLKKL---FPKV 1060
N L+ + E + TE K+ + ++ +TS ER Q + + KK+ ++
Sbjct: 1679 NLLQAELEELRAVVEQTERSRKLAEQELIETS-ERVQLLHSQNTSLINQKKKMDADLSQL 1737
Query: 1061 SVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVL 1120
+ E + EK K +EE+K + + M ++ + + L
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1797
Query: 1121 AETEGI--------LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1172
E E I LQKL+ V + EN+ + + + +++K M+ SE+ ++ L +
Sbjct: 1798 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMR----KSERRIKELTYQ 1853
Query: 1173 -NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGD 1231
+D +NL R L+ ++K +++ Y + E + Q N L+K R KV +
Sbjct: 1854 TEEDRKNLLR----LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-------KVQHE 1902
Query: 1232 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1264
L +A++ ++ +S++ K + I ++ E
Sbjct: 1903 LDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 124 bits (310), Expect = 8e-28
Identities = 241/1203 (20%), Positives = 511/1203 (42%), Gaps = 154/1203 (12%)
Query: 26 WLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFK 85
W +MK + L K +K + + ++ K+ +K E + L E +
Sbjct: 827 WPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND 886
Query: 86 LSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L + E D +A + + + + K K+ LE++ ++ + K +
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 146 VPVTKQPTPPSEAAASK----KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETK 201
K+ E +K K + K KN +++ E + +K ++AL QE
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL---QEAH 1003
Query: 202 QESGSGKKKASSKKQKTENVFVDEPLIHATTYIPL-----MDNADSSPVVDKREVIDLLK 256
Q Q +++ +E ++ T + +D+ + S +K+ +DL +
Sbjct: 1004 Q-------------QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 257 PDQ-VEGIQKSGTKKLKT-ETDKENAE--VKFKDFLLSLKTMMFSEDEALC--VVDLLKE 310
+ +EG K + + E DK+ + +K KDF L+ +++AL + LKE
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 311 KSGVIQDA-----LKKSSKGELTTLIHQL-QEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
I++ +++++ ++ L L +E +++ ++E AT Q M
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS------VQIEMN 1164
Query: 365 EKERSNVVITRMKDRIGTLEKEHNV--FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL 422
+K + R TL+ E + K S E + Q+V++++E E +
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 423 KQENGILRDAVSNTTNQLESKQSAE---------LNKLR---QDYARLVNELTEKTGKLQ 470
K E L D SN +++K + E +N+ R ++ R VN+LT + KLQ
Sbjct: 1225 KLE---LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 471 QEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQ 530
E +L QL E E ++ T + E ++ L+ + AK
Sbjct: 1282 TEN----------GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 531 SLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHS 590
+L S D + ++Q E+ E + ++Q +L + +++ Q+ +
Sbjct: 1332 ALQSARHDCDLLREQYEE---------------ETEAKAELQRVLSK---ANSEVAQWRT 1373
Query: 591 QIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE 650
+ +T A EEL + + +++++ E+++ + + +S E+ +QN E
Sbjct: 1374 KY--ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN-------E 1424
Query: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKI----RLLEEQLQHEISNKMEEFKILNDQ 706
++ L AAA L+K Q++ DKI + E+ Q E+ + +E + L+ +
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNF----DKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 707 ----NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
A + ++ L+T E NK++ E++ ++ KT+ EL + A K
Sbjct: 1481 LFKLKNAYEESLEHLETFKRE--NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKM 1538
Query: 763 EELNAIRTENSSLT-KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL 821
E +A+ +SL +E + L+A Q+ F + E+++ + EKD ++ E +
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRA----QLEFNQIKAEIERKLAEKDEEM----EQAKRNH 1590
Query: 822 LKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN 881
L+V + ++Q S+ ++ + L+ K++ M+ L E E L++ + + Q++
Sbjct: 1591 LRVVD---SLQTSLDAETRSRNEALRVKKK----MEGDLNEMEIQLSHANRMAAEAQKQV 1643
Query: 882 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN-----ELKRLEAMLKERESDLSSK 936
+SL++ +++ Q L +A A+ + I + E+ N EL+ L A++++ E
Sbjct: 1644 KSLQSLLKD-TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1702
Query: 937 TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK 996
Q L + + +L SQ L Q + + +L ++ +E E+ + N + K
Sbjct: 1703 EQELIETSERVQLLHSQNTSLINQKKKMDA------DLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 997 DAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1056
A+ +L+++ + A E+M + + +T K+ Q +++ E A + KK
Sbjct: 1757 KAITDAAMMAEELKKE----QDTSAHLERM-KKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Query: 1057 FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKY 1116
K+ E L +K+ E + G SE ++ E + ++ LL+L+
Sbjct: 1812 LQKLEARVRELENE-LEAEQKRNAESVKGMRKSER-RIKELTYQTEEDRKNLLRLQ---- 1865
Query: 1117 KSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT---IKQMQSSFTSSEQELERLRSEN 1173
++ + + ++ +R E+ E + + + K + + + +E ++ +LR+++
Sbjct: 1866 -DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1924
Query: 1174 KDI 1176
+DI
Sbjct: 1925 RDI 1927
Score = 120 bits (302), Expect = 7e-27
Identities = 185/913 (20%), Positives = 380/913 (41%), Gaps = 112/913 (12%)
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
K + E + + ++ T+LK L+++E R +E++ + E + DLQ + A+++
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQE----KNDLQLQVQAEQD 896
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ 587
+ + + +K QLE ++ ++ E + L + + + ++ LK I
Sbjct: 897 NLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDD 956
Query: 588 FHSQI--------AAQTSASVLAEE---LHKVIAEKDKQIKQTEDSLASERDRLTSKEEE 636
+ A + L EE L ++IA+ K+ K +++ D L ++E++
Sbjct: 957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Query: 637 LKDIQNMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKDDKIRLLE---EQL 689
+ + L+ +V L+ ++ +LE K++ + + + I LE +QL
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Query: 690 QHEISNKMEEFKILN---DQNKALKSEVQK----LQTLVSE-----QPNKDVVEQMEKCI 737
+ K E LN + +AL S++QK LQ + E + + ++EK
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Query: 738 QEKDEKLKTVEELLETG----LIQV---ATKEEELNAIR--TENSSLTKEVQDLKAKQND 788
+ +L+ + E LE +Q+ +E E +R E ++L E ++
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKV-ANKEKTVQLSITSKVQELQNLLK 847
S A L E++ + K K++ + + EL V +N E+ ++ L+ + +
Sbjct: 1197 ADSVAELGEQIDNLQRVKQ-KLEKEKSEFKLELDDVTSNMEQIIKAK-----ANLEKMCR 1250
Query: 848 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 907
E+QMN ++ EE ++ + + LQ EN L + E KEA SQ
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE------KEA-LISQLTR 1303
Query: 908 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 967
++ ++ +LKR L+E ++ LQ + + L + Q E+ +
Sbjct: 1304 GKLTYTQQLEDLKR---QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK------ 1354
Query: 968 FPPHEELLKVISEREKEISGLWN---ELDSLK--DAVEHQRKKNNDLREKNWEAMEALAS 1022
EL +V+S+ E++ W E D+++ + +E +KK ++ EA+EA+ +
Sbjct: 1355 ----AELQRVLSKANSEVA-QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNA 1409
Query: 1023 TEKMLQDKVNKTSKERQQQVE--AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1080
L+ KT Q ++E V++E K + EW +E+
Sbjct: 1410 KCSSLE----KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 1081 ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK--------SVLAETEGI------ 1126
E + + + KLK A E +L LE K + S L E G
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYE-ESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH 1524
Query: 1127 -LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE------NKDIENL 1179
L+K+++ +E E+ + + ++E+ +++ + ++ E ++++E KD E
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 1180 RREREHLEM--ELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1237
+ +R HL + L+ + + E +K ++ L ++ + + ++A + K +
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Query: 1238 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV-----SLNQTVTQLQQLLQAVN 1292
SL+ + K + D V N D+ E+ + L V Q ++ +
Sbjct: 1645 SLQSL-LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Query: 1293 QQLTKEKEHYQVL 1305
Q+L + E Q+L
Sbjct: 1704 QELIETSERVQLL 1716
Score = 35.8 bits (81), Expect = 0.28
Identities = 43/224 (19%), Positives = 99/224 (44%), Gaps = 17/224 (7%)
Query: 1091 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDE 1147
++K L + EM ++ + E + K L ++E ++L+ S+ QE+N +++V
Sbjct: 835 KIKPLLKSAEREKEMASMKE-EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1205
+ + + +L ++ K++ + E + EL +K ++E E
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-----DECS 948
Query: 1206 ELKAQLNE---TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1262
ELK +++ TL K+ E++ + +L + L+ I +K+ K + ++ +
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK---EKKALQEAHQQ 1005
Query: 1263 PETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 165 bits (418), Expect = 2e-40
Identities = 311/1476 (21%), Positives = 622/1476 (42%), Gaps = 250/1476 (16%)
Query: 31 ETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL 90
ETL E L K ++Q ++ K + E +K + +E+++ + E + + + DAL
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEK-EIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 91 AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASK------------I 138
+E ET KK+ K K +E+ V K DA K I
Sbjct: 82 LLEK----------AETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEI 131
Query: 139 PGKKVEPVPVTKQPTPPSEAAASKKKP------------GQKKSKNGSDDQDKKVETLMV 186
K E + V + SE A+ +K Q K +N S+D KK++ +
Sbjct: 132 ENLKNELMAVRSKY---SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 187 ---PSKRQEALPLHQETKQESGSGKKKA----------SSKKQKTENVFVDEPL----IH 229
P ++ L L ++ + K+ S QK N +E L IH
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 230 ATTYIPLMDNADSSPVVDKREVIDL--LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDF 287
LM ++S + E+ L LK + V+ + E ++N + K++
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVK----------QCEASEKNIQKKYECE 298
Query: 288 LLSLK--TMMFSEDEALC---------VVDLLKEKSGVIQDALKKSS------KGELTTL 330
L +L+ T ++D +C V ++ EK ++D LK+ K E+T +
Sbjct: 299 LENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYM 358
Query: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
+ + + +K++ ++ + E++ KE VI ++K + L K+ F
Sbjct: 359 NNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ---F 415
Query: 391 QNKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAVSNTTNQLES----KQS 445
+ +E Q ++ + Q ++ E E ++ ++E L + Q E+ KQ
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 446 AELN--KLRQDYARLVNELTEKTGKLQQE-EVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
A LN LR+ L EL E GK+ QE E K+ +L+ +L+ A + +
Sbjct: 476 AILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLE 535
Query: 503 YIRKRTAEHEA--AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL------- 553
+ + E+E +QQ+L + EN +++L K L+S Q + L +L
Sbjct: 536 TVNRLQGENEKLLSQQELVPEL---ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 554 -----------------MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
M++ K+ +EE L +++ +EQ ++++Q +++
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 652
Query: 597 SASVLAEELH-----------KVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDI---- 640
++ ++ + KV++E + + SL E ++L+S++++L +D+
Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712
Query: 641 -QNMNFLLKAEV----QKLQALANEQAAAAHELEKMQ-QSVYVKDDKIRLLEEQLQHEIS 694
Q + +LK + +KLQ + EQ LE Q Q ++VK L+E + E+S
Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE-MGSEVS 771
Query: 695 NKMEEFKILNDQNKALKS--EVQKLQTLVSEQPNKDVVEQME--KCIQEKD----EKLKT 746
EE ++N +S ++ + + ++ Q ++ V+E + KC+QE+ E+LK+
Sbjct: 772 EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKS 831
Query: 747 V-------EELLETGLIQVATKEEELNA-----------IRTENSSLTKEVQDL------ 782
+ + LL L ++ +++E L + R EN +L +V+++
Sbjct: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK 891
Query: 783 -KAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLS----ITS 837
+ + F E LK ++ +K+ + + E +L + L + K LS +
Sbjct: 892 SEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEE 951
Query: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 897
K++ L+ K KEE++N +K V + +K+L ++ K Q ++EE ESL++ +++
Sbjct: 952 KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD 1011
Query: 898 EASSASQFEELEIVLKEKENEL-------KRLEAMLKERESDLSSKTQLLQDVQDENKLF 950
A ++ L + +++ +L E +++ L + T + + +N+
Sbjct: 1012 LIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 951 KSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR 1010
++IE L Q N + + K + ++E E L E ++ N+L
Sbjct: 1072 LARIETL-QSNAKLLEVQILEVQRAKAMVDKELEAEKLQKE-----QKIKEHATTVNELE 1125
Query: 1011 EKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEA---KEVLKKLFPKVSVPSN-L 1066
E + + +K +Q+ + K+ QQ + +E + ++K+L K++ +N +
Sbjct: 1126 ELQVQLQKEKKQLQKTMQEL--ELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183
Query: 1067 SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT-----LLQLECEKYKSVLA 1121
E +K+ +E + EE+ L+ +++ +E +T L++ + E S A
Sbjct: 1184 EDLEQEIKIQKQKQETL-----QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA 1238
Query: 1122 ETEGILQKLQRSVEQEENKWKVKV---------DESHKTIKQMQSSFTSSEQELERLRSE 1172
ET+ ++ + E E ++ +V+V E HK + ++ TS+EQ L +
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQRTLSAY 1295
Query: 1173 NKDIENLRREREHLEMELEKAEMERSTYVTEVRE-LKAQLNETLTKLRTE--QNERQ--- 1226
+ + L+ E + E E +Y V LK Q N+++++ TE + ER+
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLE 1355
Query: 1227 ----KVAGDLHKAQQSLELIQSKI--VKAAGDTTVIENSDVSPETESSEKE--------- 1271
++ L +Q +L++ S++ +++ DT + ++ + ET S E E
Sbjct: 1356 MLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQ 1415
Query: 1272 ----TMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
M QTV+QL + + + H Q
Sbjct: 1416 SENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Score = 84.7 bits (208), Expect = 5e-16
Identities = 154/880 (17%), Positives = 375/880 (42%), Gaps = 105/880 (11%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRE 113
+K+ E+ +++K+ +Q+ L ++ R + + VE+ V +T S
Sbjct: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE---------VSQTCSKSEI 894
Query: 114 RKKKEK-------KQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPG 166
+KEK KP+LE++ +++ A I K + K P+ ++ +S K+
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKD----SLAKSPSVKNDPLSSVKELE 950
Query: 167 QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEP 226
+K + ++K+ K + + + K+E S +K+ + K++ E++ ++
Sbjct: 951 EKIENLEKECKEKE-------EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 227 LIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKD 286
+ A+ L+ A+S K +++ K + ++K + E+ + ++
Sbjct: 1004 QLSASMR-DLIQGAESY----KNLLLEYEKQSEQLDVEKERANNFEHRI--EDLTRQLRN 1056
Query: 287 FLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVK- 345
L +T+ ++ L ++ L+ + +++ + + + + ++ + E +KL K
Sbjct: 1057 STLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAK--AMVDKELEAEKLQKEQKI 1114
Query: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----- 400
++ A T + ++L ++ +KE+ + T + + + + N Y+
Sbjct: 1115 KEHATTVNELEEL--QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Q++ K ++ E +E EI KQ+ L++ +++ + ++ + K++Q +
Sbjct: 1173 NQKLTNKNNKI-EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN-TKIKQLLVKTKK 1230
Query: 461 ELTE----KTGKLQQEEVQKKNAEQAATQL---KVQLQEAERRWEEVQSYIRKRTAEHEA 513
EL + +T L + K E + Q+ K+QL E ++ +++ +H+
Sbjct: 1231 ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR 1290
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
Q + A + E ++ ++ + + R+ +++ ++ NK S Q + +
Sbjct: 1291 TLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK---NKSMS-QAETEG 1346
Query: 574 ILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
++ E L+ I Q ++ +Q + + EL + +E D +++ L +
Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE 1406
Query: 633 KEEELKDIQNMNFLLKAE-VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH 691
E+L IQ+ N ++K+E Q + L ++ + D++R L+E+ +
Sbjct: 1407 LREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------DQVRHLQEEHRK 1456
Query: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQ---------MEKCIQEKDE 742
+ ++ + Q LK+E + S+Q K++ E+ M +E+ E
Sbjct: 1457 TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGE 1516
Query: 743 KLKTVE-ELLETGLIQVATKEEELNAIRTE------NSSLTKEVQDLKAKQNDQVSFASL 795
++T + E + + + E+ LN+ T+ ++ TKE +L K + A
Sbjct: 1517 GMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKE--ELVQKLSSTTKSADH 1574
Query: 796 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLL-------KG 848
+ L + + + +LL++E+ ++ ++ + + + ++ L+N+L G
Sbjct: 1575 LNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSA--ANLEYLKNVLLQFIFLKPG 1632
Query: 849 KEEQ-----MNTMKAVLEEKEKDLANTGKWLQDLQEENES 883
E + +NTM + E++ LA + +EEN S
Sbjct: 1633 SERERLLPVINTMLQLSPEEKGKLAAVAQG----EEENAS 1668
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 165 bits (418), Expect = 2e-40
Identities = 285/1403 (20%), Positives = 597/1403 (42%), Gaps = 207/1403 (14%)
Query: 34 YDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALA-V 92
YDE+ + ++ + + D K E ++ K+K +Q ++ E + R +L + LA +
Sbjct: 963 YDEMSPAGQISKEELQHEFDLLKKENEQRKRK-LQAALINRK--ELLQRVSRLEEELANL 1019
Query: 93 EDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEE-QVIKESDASKIPGKKVEPVPVTKQ 151
+D+ +PL+ E +++ KE +K V + Q I+ I K+VE + K
Sbjct: 1020 KDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 152 PTPPSEAAASKKKPGQKKSKNGS-DDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK 210
+ AA ++ K N + D+ +++ L +A+ T S
Sbjct: 1080 LE--EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 211 ASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK 270
+ K E V + P ++ + KP+ E I
Sbjct: 1138 VALVK---ETVVISPPCTGSSEH---------------------WKPELEEKI------- 1166
Query: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTL 330
L E +KE + K ++ L S K ++ +EK +++ LK+ K + L
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKA----------ILKKAQEKERHLREELKQQ-KDDYNRL 1215
Query: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM--TEKERSNVVITRMKDRIGTLEKEHN 388
Q E+ K + + + + ++ + T+++ S +++ + ++H+
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 389 ---VFQNKIHVSYQETQQMQMKFQQVRE--QMEAEIAHLKQENGILRDAVSNTTNQLESK 443
V ++ + + + Q Q++A++ ++ E L VS+TT++L +K
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL-TK 1334
Query: 444 QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQA--ATQLKV------------- 488
+S E+ +L++ + E+ + EV ++ +Q ++QL++
Sbjct: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKL 1394
Query: 489 -QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT-DTLVSKQQL 546
+LQ+ + EE SY+ + +E EAA +Q++ + +E+ +++LH++L +++
Sbjct: 1395 DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI 1454
Query: 547 EQRLMQLMESEQK--RVNKEESLQMQVQD-----ILEQNEALKAQIQQFHSQIAAQTSAS 599
+Q ++L E +QK + +E + Q+Q ++ + EALK A+ +
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 600 VLAEELHKVIAEKDKQIKQTEDSLA------SERDRL-TSKEEELKDIQNMNFLLKAEVQ 652
L + L V ++ Q K+ + L ERD+L T + L + Q+++ ++
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNK---- 708
L+ L ++ E+E ++ S + + + ++LQ E ++ ++ ++++ +
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
Query: 709 ---ALKSEVQKLQTLV--SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
A++ E Q+L + +E K+ +Q+++ QE +E + + + ++ ++ EE
Sbjct: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
Query: 764 ELNAIRTE---NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
E + +R E KE + N AS+ EEL++V E + K + L+
Sbjct: 1695 ENDRLRAEVHPAGDTAKECMETLLSSN-----ASMKEELERVKMEYETLSKKFQSLMS-- 1747
Query: 821 LLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN-TGKWLQDLQ- 878
EK S++ +VQ+L++ ++G + ++A EK + N T + Q +
Sbjct: 1748 -------EKD---SLSEEVQDLKHQIEGNVSKQANLEAT--EKHDNQTNVTEEGTQSIPG 1795
Query: 879 --EENESLKAHVQEVAQHNLKEASSA--------SQFEELEIVLKEKENELKRLEAMLKE 928
EE +SL + ++ A SA S +E+ L++ + +R+ + +E
Sbjct: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE 1855
Query: 929 RESDL-------SSKTQLLQDVQDENKLFKSQIEQLKQQNY--QQASSFPPHEELLKVIS 979
++ + + K LL + ++ K E++ + N QQ LK +
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915
Query: 980 EREKEI--SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1037
E EK+ L N+L L ++ + + D + KN E L S K L+ V++ +E
Sbjct: 1916 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN----ELLESEMKNLKKCVSELEEE 1971
Query: 1038 RQQQV-EAVELEA---KEVLKKLFPKVSVPSNLSYGEWLHGFEKKA--------KECM-- 1083
+QQ V E ++E+ KE L+K+ P N S+ + L K+ K+C+
Sbjct: 1972 KQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRY 2031
Query: 1084 ----------------AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG-- 1125
T +++++ + L +A E Q E +K +L +T+
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091
Query: 1126 ---ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1182
+ L+ E + NK VK K + + E+ L+ ++ + ++ LRRE
Sbjct: 2092 ARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE 2151
Query: 1183 REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKL-------RTEQNERQKVAGDLHKA 1235
+ HLE + + ++ + EV++L+ L+ T+T+L + Q++R +V + K
Sbjct: 2152 KVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
Query: 1236 QQSL-ELIQSK--IVKAAGDTTVIENSDVSPETESSEKETMSV-----------SLNQTV 1281
++ + IQSK ++ D + + + E+ +++ S QT
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 1282 TQLQQ----LLQAVNQQLTKEKE 1300
QLQQ LQ N++L + E
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLE 2294
Score = 157 bits (397), Expect = 6e-38
Identities = 282/1357 (20%), Positives = 556/1357 (40%), Gaps = 165/1357 (12%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L Q+ +++L K+ AE++K+ +E L E + ++DA ++++ +
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-QIKNELL 1954
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
N+ + S + E K++ K+K +E ++ KE KI G + EP K +
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-LEKIQGAQKEPG--NKSHAKELQ 2011
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETL--------MVPSKRQEALPLHQETKQESGSGKK 209
+K+ K+ + +K+ L V ++ Q+ L + +E ++ +K
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
KA ++ ++ L+D+ S + + L K Q
Sbjct: 2072 KAQAE---------------LASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG---- 325
K K E + E + L K M D L+E G IQ L K K
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 326 --ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL 383
L + + QL K ++++++D D K+ ++ + I +D L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 384 EKEH-----NVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAH-LKQENGILRDAVSNT 436
+ + ++ + KI++S E +Q+ Q Q++ ++ L+ EN L + T
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 437 TNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496
+ S Q+ EL KL + L ++LT+ + L++ + QK N E Q + +Q ++
Sbjct: 2297 RHLYHSSQN-ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 497 WEEVQSYI---RKRTAE-HEAA---QQDLQSKFVAKENEVQSLHSKLT----------DT 539
+E++++ + R+ T+ HE +Q + S KE +Q ++L +
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF-HSQIAAQTSA 598
L+S+++ E +++ E +K V+K L ++ I ++N KAQ+ F S + Q
Sbjct: 2416 LLSQEEEENIVLE--EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 599 SVLA------EELH-KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEV 651
+ EE H +I EKD+ I++ ++ + + D+ + N L AE+
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVK-----DDKIRLLEEQLQH-EISNK--MEEFKIL 703
+ + N+ +K V ++ ++K LEE+L+ E +N+ F L
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI-------QEKDEKLKTVEELLETGLI 756
++ + L E++ L+ +S+ + Q E + + K+E++ + L +
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
Query: 757 QVATKEEELNAIRTENSSLTKEVQD-LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
++A EEEL ++ E + E++D LK + A ++ + E+ ++
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713
Query: 816 LLEAELLKVANKEKTVQLSITS---KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
+E +LL V + K + I S + LQN E+++ +K + K+LA
Sbjct: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ--- 2770
Query: 873 WLQDLQEENESLKAHVQEVA-QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
L++ N A + E A N E +S S E+L L K+ +L L + L++ +
Sbjct: 2771 -LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQL------KQQNYQQASSFPPHEELLKVISEREKEI 985
+ S ++ + +Q+E +++E+ KQ++ Q S+ P + LK K +
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK------KAM 2883
Query: 986 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1045
S L N+ D L +++ +++ + ++ E + L + + QDK K + Q+++
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITE-LHPLKAQLQEYQDK-TKAFQIMQEELRQE 2941
Query: 1046 ELEAKEVLKKLFPKVSVPSNLSYGEW-LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1104
L + L +L + W +H K + MA + +++ L++ ++E
Sbjct: 2942 NLSWQHELHQL--------RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE--- 2990
Query: 1105 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
+S ++T+ + + QR E + D S +
Sbjct: 2991 -----------LRSSSSQTQPLKVQYQRQASPETS---ASPDGSQNLV-----------Y 3025
Query: 1165 ELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1224
E E LR++ + + +E E+ +++ S + E L QL +T LR E
Sbjct: 3026 ETELLRTQ---LNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR----E 3078
Query: 1225 RQKVAGD-------LHKAQQSLELIQSKIVKAAG----DTTVIENSDV----SPETESSE 1269
Q+ GD L K Q L+ I A G V SD P+ SE
Sbjct: 3079 NQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSE 3138
Query: 1270 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+ + Q V +L++LL+ Q + V E
Sbjct: 3139 AQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAE 3175
Score = 147 bits (370), Expect = 8e-35
Identities = 259/1227 (21%), Positives = 524/1227 (42%), Gaps = 170/1227 (13%)
Query: 182 ETLMVPSK---RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMD 238
E L+V K RQ+ + L Q K E+ ++KA+ K K + L YI M
Sbjct: 58 EQLVVELKDIIRQKDVQLQQ--KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEM- 114
Query: 239 NADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSE 298
A V+ +P E + K K TE + E ++K K + +
Sbjct: 115 KAQGGTVLPT-------EPQSEEQLSKHD--KSSTEEEMEIEKIKHK---------LQEK 156
Query: 299 DEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL 358
+E + + ++ Q A + E + QLQEK++ ++ ++ A ++ + +Q
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ--AQLSQTQAEQA 214
Query: 359 TQEMMTEKE-RSNVVITRMKDRIGTLEKEHNV---FQNKIHV---SYQETQQMQMKFQQV 411
Q+++ EK+ R + +D + L + +V Q K+ V +E ++ + QV
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
+ ++ E+ +Q N IL S Q+E AE N LR E K++
Sbjct: 275 VDLLQQELTAAEQRNQIL----SQQLQQME----AEHNTLRNTVETEREESKILLEKMEL 326
Query: 472 EEVQKK----NAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE- 526
E ++K N ++ L Q ++A + E++S +H+A ++ S ++ +
Sbjct: 327 EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQK 386
Query: 527 --NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
E+QS L D + + L+ + Q ++S Q E+ LQ + ++I + L Q
Sbjct: 387 TGQELQSACDALKDQ--NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444
Query: 585 IQQFHSQIAAQTS-ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
+ A+QTS V E V E +++ L +E+ L EL++++
Sbjct: 445 ----QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ----LQHEISNKMEE 699
N L +++ L+A N A E+ ++ V + + + EE L++ S K +E
Sbjct: 501 NEKLSSQITLLEA-QNRTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHKE 558
Query: 700 FKILNDQNKALKSEVQ----KLQTLVSEQPNKDVVEQMEKCIQEKDE----KLKTVEELL 751
+L + K + E+ +LQ +E+ + +V++Q E E + K+K E
Sbjct: 559 LSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDT 618
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
+ +E L A+ E +S + +++ ++++S ELK + D +
Sbjct: 619 GQDFPLMPNEESSLPAVEKEQAS-----TEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 812 SVEELLEA---ELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 868
+V ++ + EL ++ ++ ++L+ + + L K ++++ + ++EE +K+
Sbjct: 674 AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733
Query: 869 NTGKWLQDLQEENESLKAHVQEVA------------QHNLKEASS--------------- 901
N L EE + L + V+E++ + NL EA
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
Query: 902 -ASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 960
Q L I K K+ +++ L+ L + + S ++ L++ +Q + + +S++ + ++
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 961 NYQQASSFPPHEELLKVISEREKEISGL-------WNELDSLKDAVEHQRKKNNDLREKN 1013
+S EEL + +S++E EI+ + ++++L+ +E + ++ ++
Sbjct: 854 VRHISSKV---EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSM 910
Query: 1014 WEAMEALASTE-------KMLQDKVNKTSKERQQQVEAVE--LEAKEVLKKLFPKVSVPS 1064
E M L + K L++++N S+ + + E VE E LK+ + ++S
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970
Query: 1065 NLSYGEWLHGF-------EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
+S E H F E++ ++ A +E+ +L+E L L+ E K
Sbjct: 971 QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE-----ELANLKDESKK 1025
Query: 1118 SV-LAETE-GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD 1175
+ L+ETE G +++ + + E E K E +KQ T SE+E+E L+ KD
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQ-----TISEKEVE-LQHIRKD 1079
Query: 1176 IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNET---LTKLRTEQNERQKVAGDL 1232
+E E + +++ ++ L+A+++E + KL T + GD
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD--GD- 1136
Query: 1233 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE------SSEKETMSVSLNQTVTQLQQ 1286
S+ L++ +V + T E+ PE E EKE + L + +T +
Sbjct: 1137 -----SVALVKETVVISPPCTGSSEH--WKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
Query: 1287 LLQA-------VNQQLTKEKEHYQVLE 1306
+L+ + ++L ++K+ Y L+
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQ 1216
Score = 138 bits (348), Expect = 3e-32
Identities = 246/1240 (19%), Positives = 510/1240 (41%), Gaps = 198/1240 (15%)
Query: 167 QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEP 226
QK + G + + K+ + K Q AL +E +E+ S +++ S + E +
Sbjct: 1466 QKPEEIGEESRAKQ----QIQRKLQAALISRKEALKENKSLQEELSLARGTIERL----- 1516
Query: 227 LIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDK---ENAEVK 283
T + +++ S+ +K V+ L Q E KL TE D+ EN +
Sbjct: 1517 ----TKSLADVESQVSAQNKEKDTVLGRLALLQEE------RDKLITEMDRSLLENQSLS 1566
Query: 284 FKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAA 343
L L +ED+ V ++ KS I ++ + K + +LQ++ ++L
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHK------ELQKEYEILLQ 1620
Query: 344 VKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQ 403
E+ + +R + + + + EK+ + ++ + E + ++ + QE ++
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQE-------LYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 404 MQMKFQQVREQMEAEIAHLKQENGILRDAVS----------NTTNQLESKQSAELNKLRQ 453
M+ K ++ + + +I L++EN LR V T + EL +++
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
Query: 454 DYARLVNE---LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR------WEEVQSYI 504
+Y L + L + L +E K+ + + L+ E+ EE I
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 505 RKRTAEHEAAQQDLQ---SKFVAKENEVQ-------SLHSKLTDTLVSKQQLEQRLMQLM 554
T E ++ + S+ V S H ++ + L QL++R+ L
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 555 ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV-LAEELHKVIA--- 610
E +QK ++L+ + +L Q +++ ++ + + EEL +V
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 611 ----EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAH 666
EKD ++ + LA + + +++ D Q N LL++E++ L+ +E
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Query: 667 EL--EKMQQSVYVKDDKIRLLE------------EQLQHEISNKMEEFKILN-------D 705
+L EK + ++ + + ++ ++LQ + K +E K L +
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQE 2033
Query: 706 QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ AL+ V+ L+ V + KD+ E Q + + K EL ++ T+ E
Sbjct: 2034 KISALERTVKALE-FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
Query: 766 NAIRTENSSLTKEVQDLKA------KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
+ +N L KE+Q K KQ D+ L + +K + EK K+++E L+A
Sbjct: 2093 RVL-ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK----KNMQEKLDA 2147
Query: 820 ELLKVANKEKTV---QLSITSKVQELQNLLKGKEEQMN-------TMKAVLEEKEKDLAN 869
+ + E+T+ Q+++ K +E+Q L + + + +M ++ +++++ +
Sbjct: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
Query: 870 TGKWLQDLQEENESLKAHVQEVAQHNLKEASSA---SQFEELEIVLKEKENELKRLEAML 926
KW + + +S + ++ LKE + + Q ++ I ++E + + RLE
Sbjct: 2208 AKKWERKFSDAIQSKEEEIR------LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
Query: 927 KERESDLSSKTQLLQDV----QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 982
+ ES ++ QL Q V Q ENK SQ+E+ + + +
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS-----------------Q 2304
Query: 983 KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1042
E++ L +EL SLKD + +E+ + E +Q+ SK +Q+
Sbjct: 2305 NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-----SKFSYEQL 2359
Query: 1043 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL--- 1099
E ++E+ +L ++++ E+K ++G + +V + E +
Sbjct: 2360 ETDLQASRELTSRLHEEINMK------------EQKIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 1100 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1159
KE E+ LL E E E I V +EENK VD++++ ++ +++
Sbjct: 2408 KEIKELENLLSQE---------EEENI-------VLEEENK--KAVDKTNQLMETLKTIK 2449
Query: 1160 TSSEQELERLRSENKDIENLRREREHLEMELEKAE-------MERSTYVTEVRELKAQLN 1212
+ Q+ +L S K + +L+ +R+ + + ++ E +E+ + E +L
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509
Query: 1213 ETLTKLRTE----QNERQKVAGDLHKAQQSLE---LIQSKIVKAAGDTTVIENSDVSPE- 1264
E + LR+ +E K+ +L + ++ L I+ K + + +N ++ +
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY 2569
Query: 1265 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQV 1304
+ EK S N+ + + LQ Q L+KE E +V
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Score = 129 bits (323), Expect = 2e-29
Identities = 274/1352 (20%), Positives = 549/1352 (40%), Gaps = 256/1352 (18%)
Query: 130 IKESDASKIPGKKVEPVPVTKQPTPP-SEAAASKKKPGQKKSKNGSDDQDKKVETLMVPS 188
+ E IPG+ E ++ P SE+ S K SK+ S + +
Sbjct: 1785 VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
Query: 189 KRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDK 248
++ L +E K+K Q EN T + + D + +
Sbjct: 1845 LKERIAGLEEE--------KQKNKEFSQTLEN--------EKNTLLSQISTKDGELKMLQ 1888
Query: 249 REV--IDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK-------------- 292
EV ++LL E + + K E +K++ E + + L L
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 293 ---TMMFSEDEAL--CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
++ SE + L CV +L +EK ++++ K S+ L +K+ A KE
Sbjct: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL-------EKIQGAQKEP 2001
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVIT----RMKDRIGTLE---KEHNVFQNKIHVSYQE 400
K K+L QE++ EK++ + R +++I LE K Q + +
Sbjct: 2002 G--NKSHAKEL-QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT----NQLESKQSAELNK--LRQD 454
T++ + + R++ +AE+A K +L D S + L+ K+ + NK ++
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKV---LLDDTQSEAARVLADNLKLKKELQSNKESVKSQ 2115
Query: 455 YARLVNELTEKTGKLQQEEV-QKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
+ +L + + +++ + +KKN ++ L+ + E E+Q + K+ E +
Sbjct: 2116 MKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQ 2175
Query: 514 AQQDLQS---KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQ 570
Q++L S + A + SL + ++ E++ ++S+++ + +E
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV 2235
Query: 571 VQDILEQN----EALKAQIQQFHS-----QIAAQTSASV---LAEELHKVIAEKDKQIKQ 618
++D L Q E LK I + + AQT + + + L E Q+++
Sbjct: 2236 LKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
Query: 619 TEDSLASERDRLTSKEEELKDIQNM-----NFLLKAEVQK--LQALANEQAA-------- 663
T S ++ L E ELK +++ N L K + QK L+ + +Q A
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 664 ---------AAHEL-EKMQQSVYVKDDKI-------------RLLEEQLQHE-------- 692
A+ EL ++ + + +K+ KI + E + QH+
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 693 -ISNKMEEFKILNDQNK-ALKSEVQKLQTL-------VSEQPNKD-VVEQMEKCIQEKDE 742
+S + EE +L ++NK A+ Q ++TL + ++ D V+ M ++D
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSF-----ASLV- 796
+ ++L E L + K++ + EN+ L +E++ L++ +D S A L+
Sbjct: 2476 IVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535
Query: 797 --EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMN 854
E+L +VI KD + K +LLE +L + NKE + +K +L+ LK EE
Sbjct: 2536 YREDLNQVITIKDSQQK---QLLEVQLQQ--NKE------LENKYAKLEEKLKESEEANE 2584
Query: 855 TMK----AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEEL 908
++ A+ EEK QDL +E ESLK + ++ + L+E + +
Sbjct: 2585 DLRRSFNALQEEK-----------QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
Query: 909 EIVLKEKENELKRLEAML---KERESDLSSKTQLLQ--------DVQDENK--------- 948
LK KE E+ RL A+ ++R ++L + +Q +++D+ K
Sbjct: 2634 ---LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHD 2690
Query: 949 --LFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK----EISGLWNELDSLKDAVEHQ 1002
+ +++ E +++ + A E+ L ++++ K +I + SL+++ +H
Sbjct: 2691 AGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA 2750
Query: 1003 RKKNNDLREKNWEAMEALASTEK----------MLQDKVNKTSKERQQQVEAVELEAKEV 1052
++ ++L+ K +++ LA ++ +L + + + + +E +++
Sbjct: 2751 NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 1053 LKKLFPKVSVPSNL--SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1110
L K + + S L SY + + F K A S E L ++L++ + Q
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQ-VQSFSK------AMASLQNERDHLWNELEKFRKSEEGKQ 2863
Query: 1111 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
+ + AE + L+K S++ + D K +K +Q + QE+ L
Sbjct: 2864 RSAAQPSTSPAEVQS-LKKAMSSLQNDR-------DRLLKELKNLQQQYLQINQEITELH 2915
Query: 1171 SENKDI--------------ENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLT 1216
+ E LR+E + EL + ME+S++ R +K Q ++
Sbjct: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
Query: 1217 KLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESS---EKETM 1273
+ + Q + +L + + ++ + + A T SP+ + E E +
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET-----SASPDGSQNLVYETELL 3030
Query: 1274 SVSLNQTVTQLQQ---LLQAVN---QQLTKEK 1299
LN ++ ++ Q +Q +N QL +EK
Sbjct: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEK 3062
Score = 120 bits (300), Expect = 1e-26
Identities = 214/1133 (18%), Positives = 460/1133 (40%), Gaps = 135/1133 (11%)
Query: 161 SKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
S +K GQ+ + D K + ++ K ++A+ Q +Q ++K+ Q
Sbjct: 383 SLQKTGQELQS--ACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 221 VFVDEPLIHATTYIPLMDNADSSPVVDK------REVIDLLKPDQVEGIQKSGTKKLKTE 274
+ + + + T P + N + V ++ + V++L + ++LK E
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 275 TDKENAEVKFKDFLLSLKTMMFSEDEA---LCVVDLLKEKSG--------VIQDALKKSS 323
+K ++++ LL + D + +VD+ ++S V+++ +
Sbjct: 501 NEKLSSQIT----LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKH 556
Query: 324 KGELTTLIHQLQEKDKLLAAVK---EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI 380
K EL+ L+ +++E + +A +K + A + + L Q+ M + E + +MK +
Sbjct: 557 K-ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFL 615
Query: 381 GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQL 440
++ + N +E+ ++ +EQ E E L DA
Sbjct: 616 EDTGQDFPLMPN------EESSLPAVE----KEQASTEHQSRTSEEISLNDA-------- 657
Query: 441 ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV 500
EL +QD + ++ + + G+ Q+E+++ LK Q+ E E + +
Sbjct: 658 ----GVELKSTKQDGDKSLSAVPD-IGQCHQDELER---------LKSQILELELNFHKA 703
Query: 501 QSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM------ 554
Q K E +L + + S T + QL ++ +L
Sbjct: 704 QEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELR 763
Query: 555 -ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD 613
+ +Q +N E+ + + D Q +Q HS S V E L + +
Sbjct: 764 AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
Query: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQ 672
Q + + S + +L +KE E+ + + ++V++L QAL+ ++ E+ KM
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL----EITKMD 879
Query: 673 QSVYVKDDKIRLLEEQLQH------EISNKMEEFKI-LNDQNKALKSEVQKLQTLVS--E 723
Q + K + L++ ++ EIS M E + LN++ +L E++ L+ ++
Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS 939
Query: 724 QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLK 783
+ + EQ+E+ + + +E+ G I + E + ++ EN +++Q
Sbjct: 940 RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAAL 999
Query: 784 AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQ 843
+ + + S +EE + ++ K + E E+ + ++ + +TSK QE++
Sbjct: 1000 INRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE 1059
Query: 844 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 903
L K + EKE +L + K L++ E +A V+++ Q
Sbjct: 1060 IYL----------KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ---------- 1099
Query: 904 QFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD-ENKLFKSQIEQLKQQNY 962
L++K N++ L+A + E ++ + D D ++ + +
Sbjct: 1100 -------TLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
Query: 963 QQASSFPP--HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1020
+ + P E++L + E+E+ L L S K ++ ++K LRE+ ++
Sbjct: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE----LKQQ 1208
Query: 1021 ASTEKMLQDKVNKTSKERQ---QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEK 1077
LQ++ ++ SKE + Q+ ++++ +E + P + S L
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268
Query: 1078 KAKE------------CMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK---SVLAE 1122
KA E C S SE+ L+ A L ++E EK + V +
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328
Query: 1123 TEGILQKLQR--SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLR 1180
T + +K + ++++ NK ++++ + + S +Q+LE + + +E+LR
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388
Query: 1181 REREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
+ L+ EL+K ++ V+ + ++ LTK++TE E++ + LH
Sbjct: 1389 ELQPKLD-ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH 1440
Score = 118 bits (296), Expect = 3e-26
Identities = 201/1079 (18%), Positives = 455/1079 (42%), Gaps = 188/1079 (17%)
Query: 387 HNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA 446
+N Q + +Q+ ++ + + Q + ++ + R A N +L+ A
Sbjct: 43 NNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA 102
Query: 447 ELNKLRQDYARLVNELTEKTGKL----QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
+L L + + E+ + G + Q E Q ++++T+ ++++++ + + +E +
Sbjct: 103 KLTSLN----KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN 562
I A+ AQ E QS +++ + ++ KQQL+++ + + + Q +++
Sbjct: 159 LISTLQAQLTQAQA---------EQPAQS-STEMEEFVMMKQQLQEK-EEFISTLQAQLS 207
Query: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622
+ ++ Q Q + E++ + Q++ ++ + + + E+ + + +++++ E+S
Sbjct: 208 QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEES 267
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN--------EQAAAAHELEKMQQS 674
L + ++EL + N +L ++Q+++A N E+ + LEKM+
Sbjct: 268 LVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE 327
Query: 675 VYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV----QKLQTLVSEQPN---- 726
V + +L LQ E+ + +E+F+ L+S QK + + E+ +
Sbjct: 328 VAER----KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
Query: 727 --KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKA 784
K E C KD+ K +++ E + T ++ + ++ ++ +++ + L
Sbjct: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Query: 785 KQND---QVSFASLVEE-------------LKKVIHEKDGKIKSVEELLEAELLKVANKE 828
+Q++ Q SF + E K+V+ ++ K + +E E LK N++
Sbjct: 444 QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK 503
Query: 829 KTVQLSITS----------KVQEL-------QNLLKGKEEQMNTMKAVLEEKEKDLANTG 871
+ Q+++ +V E+ + +E + ++ +K K+L+
Sbjct: 504 LSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL 563
Query: 872 KWLQDLQEENESLKAHVQ----EVAQHNLKEASSASQFE-------ELEIVLKE------ 914
+++ QEE LK +Q E A H + + Q E ++++ L++
Sbjct: 564 LEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623
Query: 915 -KENELKRLEAMLKERES------------------DLSSKTQ----LLQDVQDENKLFK 951
NE L A+ KE+ S +L S Q L V D + +
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 952 SQIEQLKQQNYQQASSFPPHEELL-KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR 1010
++E+LK Q + +F +E+ K + E+ KEIS L ++ K ++ L
Sbjct: 684 DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 1011 EKNWEAM----EALASTEKMLQDK---VNKTSKERQ----------------QQVEAVEL 1047
E+ + + E TE Q K +N ERQ +Q+ ++ +
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 1048 EAK------EVLKKLFPKV----SVPSNL--SYGEWLHGFEKKAKECMAGTSGSEEVKVL 1095
EAK EVL+ V S S L S L E + E G+E V+ +
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE------GAERVRHI 857
Query: 1096 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE----------------- 1138
K++E + + +LE K +L E + ++ LQ+++E+++
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 1139 NKWKVKVDESHKTIKQMQSSFTSSEQ-ELERLRSENKDIENLRREREHLEM--ELEKAEM 1195
N+ K + KT+K+ + + +E+ + E++ +N+ L++ + + ++ K E+
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 1196 E------RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKA 1249
+ + R+L+A L L+ +++A ++++ + L +++ +
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
Query: 1250 AGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE---KEHYQVL 1305
D EN + S + +S+ + + + L QT+++ + LQ + + L ++ +E +Q L
Sbjct: 1038 EEDK---ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 162 bits (411), Expect = 1e-39
Identities = 316/1447 (21%), Positives = 608/1447 (42%), Gaps = 242/1447 (16%)
Query: 29 MKETLY--DEVLAKQKREQKLIPTKTDKKKAEKKKNKK---KEIQNGNLHESDSESVPRD 83
M ETL +E +A+ + K + T+ ++ + +K+K+++ +E++ +E R
Sbjct: 373 MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK 432
Query: 84 FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPG-KK 142
K A D+Q+ + E S+++ + K++ V+K+S +I +K
Sbjct: 433 LK-----AEMDEQIKTIEKTSEEERISLQQELSRVKQEVV----DVMKKSSEEQIAKLQK 483
Query: 143 VEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQ 202
+ + ++ ++ ++++ Q++ K + + + ++QE+L L + Q
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 203 ESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEG 262
KK ++ + E + T + L + + S +K + DL
Sbjct: 544 -----KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL-------- 590
Query: 263 IQKSGTKKLKTETDKENAEV-----KFKDFLLSLKTMMFSEDEALCV--VDLLKEKSGVI 315
L+ E +K N E+ K K L SLK + +AL + +LK++
Sbjct: 591 -----AVHLEAEKNKHNKEITVMVEKHKTELESLK----HQQDALWTEKLQVLKQQYQTE 641
Query: 316 QDALKKSSKGELTTLIHQLQEKDKLLAA-VKEDAAATKDRC--KQLTQEMMTEKERSNVV 372
+ L++ + E TL L++K+ + A ++E T ++ KQ E ++ E S V+
Sbjct: 642 MEKLREKCEQEKETL---LKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS-ELSEVL 697
Query: 373 ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD- 431
R K LE+E +V +++ QE + +M Q+ Q + + + E I R
Sbjct: 698 KARHK-----LEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSIQRTE 751
Query: 432 -AVSNTTNQLE----------SKQSAELNKLRQDYARLVNELTEKTGKLQQ-EEVQKKNA 479
A+ + NQLE + A + L D R EL + + KL + Q
Sbjct: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
Query: 480 EQ--AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT 537
EQ A + QLQ+ E + + K+ AE EA ++D+ ++ A + +VQ L +L
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Query: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQV-----QDILEQNEALKAQIQQFHSQI 592
+Q + L Q+ ES+ + NKE+ Q+ IL+ E K +I+ ++
Sbjct: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 593 AA-QTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----EEEL-KDIQNMNFL 646
+A + S +L EE ++K++++ + ++ L K E +L K+++N
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 647 LKAEVQKLQA--LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF-KIL 703
L + ++ A L QA +A + + + + ++I L E + E+++ + + K L
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ---EKDEKLKTVEELLETGLIQVAT 760
N Q E+Q++ + ++ ++V E +K + EK+E K + L E G+ Q T
Sbjct: 1052 NQQ----AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 761 KEE-------------------------------ELNAIRTENSSLTKEVQDLK-AKQND 788
E +LN EN+ L +++ +LK + D
Sbjct: 1108 LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED 1167
Query: 789 QVSFASLVEELK---------KVIHEKDGK-----------------------IKSVEEL 816
+ + L +LK K HEK K K E L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 817 LEA---ELLKVAN------------------KEKTVQLSITSKVQELQNLLKGKEEQMNT 855
LEA EL+ +++ K K L T V EL+ L+ E+ NT
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 856 MKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE----ELEIV 911
+ ++ L ++ ++ + ESL + + + + +AS+ E +L+
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQD--VQDENKLFKSQ----IEQLKQQNYQQA 965
L E N + ++ LKE++ ++SS ++ L D VQ +N + S+ I L++Q ++
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEK 1407
Query: 966 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1025
ELL + + ++ L E S + V+ K ++ ++K +T K
Sbjct: 1408 C------ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
Query: 1026 MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1085
LQ ++ SKE ++ E + L LK+ + + + GE + K+K
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINL-----LKEELDQQNKRFDCLKGEM---EDDKSKMEKKE 1513
Query: 1086 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVL--------AETEGILQKLQRSVEQE 1137
++ E+K ++ E ++ T +E E VL E + ++QKLQ E
Sbjct: 1514 SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
Query: 1138 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE----NKDIENLRREREHLEMELEK- 1192
E K +V E+ + I +++ S + ELE + E N +++ E + LE LE
Sbjct: 1574 EEK-DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632
Query: 1193 -----AEMERST---YVTEVRELKAQLNET-----------LTKLRTEQNERQKVAGDLH 1233
AE++R ++L +Q+ E L++L T+ ER++ L
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 1234 KAQQSLELIQSKIV------KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL 1287
+ +S+E QS+ + K T E +D + + +E +SV L + +T+ ++L
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV-LQRNLTEKEKL 1751
Query: 1288 LQAVNQQ 1294
LQ V Q+
Sbjct: 1752 LQRVGQE 1758
Score = 155 bits (392), Expect = 2e-37
Identities = 288/1388 (20%), Positives = 584/1388 (42%), Gaps = 236/1388 (17%)
Query: 74 ESDSESVPRD---FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI 130
ESD E V D K + L + + ET S +E+ +K L+EQ+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324
Query: 131 KE-SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSK 189
+ + KI K + TK T +A ++ Q K ++ + + ETL + K
Sbjct: 325 ERLQELEKI--KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM--K 380
Query: 190 RQEALPLHQETKQESGSGKK-----------------KASSKKQKTENVF------VDEP 226
+E L KQ + G++ KA S QKTE +DE
Sbjct: 381 EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440
Query: 227 L--IHATTYIPLMDNADSSPVVDKREVIDLLKP---DQVEGIQKSGTKKL--KTETDKEN 279
+ I T+ + V K+EV+D++K +Q+ +QK K+L K + +
Sbjct: 441 IKTIEKTSEEERISLQQELSRV-KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 280 AEVKFKDFLLSLKTMMF-SEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKD 338
+ + ++F +K + S+ E L + +++ + + L+ K LT ++L++
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 339 K-----------LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM----KDRIGTL 383
+ L +++++ K++ K L + EK + N IT M K + +L
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 384 EKEHN-VFQNKIHVSYQETQQMQMKFQQVREQMEAEI------------AHLKQENGILR 430
+ + + ++ K+ V QQ Q + +++RE+ E E AH+++ N
Sbjct: 620 KHQQDALWTEKLQVL---KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 431 DAVSNTTNQLESKQS--AELNKLRQDYARLVNELTEKTGKLQQE-----EVQKKNAEQAA 483
+ + +LES S +E+ K R ++ L ++T K++QE + QK + +Q
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 484 TQL----KVQLQEAERRWEEVQSYIR-------KRTAEHEAAQQDLQSKFVAKENEVQSL 532
+ +V +Q E+ ++ + + K EH+A ++L++ E E+Q
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 533 HSKLT-----------DTLVSKQQLEQRLMQLMESEQKRV---NKEESLQMQVQDILEQN 578
+KL T ++QL Q +L++ E +R+ + ++ Q +D+ +
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+A K Q+Q Q+ Q S E ++++K S+ + ++E+ K
Sbjct: 857 DAHKIQVQDLMQQLEKQNS-------------EMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
I V+K + + E+E + Q + K+D I +L E+ + + N
Sbjct: 904 QIL---------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN--- 951
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
Q K ++ QK K++ E ++K + +++ KLK + LE +++
Sbjct: 952 -------QEKKMEKVKQKA---------KEMQETLKKKLLDQEAKLK---KELENTALEL 992
Query: 759 ATKEEELNAIRTE-----NSSLTKEVQDLKAKQNDQVSFASLVE--ELKKVIHEKDGKI- 810
+ KE++ NA E ++ ++ V L+ Q +Q+ + V EL VI + K+
Sbjct: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
Query: 811 KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 870
+ EEL E +++ KE+ V +++++ L ++E+MN L+E+ T
Sbjct: 1053 QQAEELQEIHEIQLQEKEQEV-----AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT 1107
Query: 871 GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE-ELEIVLKEK---ENELKRLEAML 926
L +LQE+ + AHV +AQ K + + E +L LKE + +L L+ +
Sbjct: 1108 ---LNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 927 KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV-----ISER 981
+E + +S T L+ +E + KS E+ + ++ F E L + +
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 982 EKEISGLWNELDSLKDA--------VEHQRKKNNDLRE----KNWEAMEALASTEKMLQD 1029
E + NEL ++ + + H + + ++E K E A ++ ++
Sbjct: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 1030 K--VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT- 1086
+ +N + ++ Q+E E + K + K + S ++ EK+A + G
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSM------KADIESLVT--------EKEALQKEGGNQ 1330
Query: 1087 --SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK 1144
+ SE+ + KE E + L E+ K E + ++L Q +N +
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS--IS 1388
Query: 1145 VDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRREREHLEMELE-----------K 1192
+ E I ++ + + EL ++++ + ++ L +E+ +++ K
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKK 1448
Query: 1193 AEMERSTYVTEVRELKAQLNETLTKLRTEQNER-QKVAGDLHKAQQSLELIQSKIVKAAG 1251
A+ + + V+EL+ QL E +K E++E+ + +L + + + ++ ++
Sbjct: 1449 AQSRFTQHQNTVKELQIQL-ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM---ED 1504
Query: 1252 DTTVIENSDVSPETESSEKETMSVSLNQTVTQ-------LQQLLQAVNQQ-------LTK 1297
D + +E + + ETE + + L +TQ L ++L+ NQQ L +
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 1298 EKEHYQVL 1305
+ +H+Q L
Sbjct: 1565 KLQHFQEL 1572
Score = 150 bits (380), Expect = 6e-36
Identities = 290/1460 (19%), Positives = 592/1460 (40%), Gaps = 208/1460 (14%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSD 88
+ L + + A+ K E++L K K +++ K + Q N H+ +S+ ++ ++S
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK-NHHQQQVDSIIKEHEVS- 746
Query: 89 ALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
++ +N +E R++ KE + E IK S+ V
Sbjct: 747 --IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
Query: 149 TKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGK 208
+ Q + A +++ Q + K D + E +++ + E ++ E + K
Sbjct: 805 SYQSATHEQTKAYEEQLAQLQQKL----LDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 209 KKASSKKQKTENVFVD-EPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSG 267
+ Q+ E + E + + T + D + ++ + I + K + + +++
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 920
Query: 268 TKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSS---- 323
K+++ T K +A+ L F E ++ +K+K+ +Q+ LKK
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK--MEKVKQKAKEMQETLKKKLLDQE 978
Query: 324 ---KGELTTLIHQLQEKDK-----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITR 375
K EL +L +K+K +L + ++A D +L + E V R
Sbjct: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038
Query: 376 -MKDRIGTLEKEHN--------VFQNKIHVSYQETQQMQMK---FQQVREQMEAEIAHLK 423
+ D I EK+ N + + ++ QE +++ K F +E+M EI LK
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Query: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA 483
+E G+ +D N + ++SA +N L QD +L L + L + + ++
Sbjct: 1099 EE-GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 484 TQLKVQLQEAERRWEEVQSYIRKRTAE-------HEAAQQDLQSKFV------------- 523
+LK+ +E +R+ E+ S ++ E HE + + L+ K +
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217
Query: 524 ------------AKENEVQSLHSKLTDTLVSK-QQLEQRLMQLMESEQKRVNKEESLQMQ 570
AK NE+ ++ S T+ ++S+ + R ++ E+ + L+ Q
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277
Query: 571 VQDILEQNEALKAQIQQFHSQIAA-QTSASVLAEELHKVIAEKDKQIKQ--TEDSLASER 627
++ + E+ L QQ Q+ + + ++ ++ EK+ K+ + ASE+
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 628 DR-LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE-KMQQSVYV--KDDKIR 683
+ +T ++EL + N L+K E+++ + + + +L ++Q S+ + K+ I
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS 1397
Query: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
L +Q E +++ + L+ + L E V + NK E +K +
Sbjct: 1398 SLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK-FSEWKKKAQSRFTQH 1456
Query: 744 LKTVEEL---LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSF-----ASL 795
TV+EL LE + K+E++N ++ E K LK + D S ++L
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 796 VEELKKV---IHEKDGKI--KSVEELLEAELLKVANKEKTVQ-LSITSKVQELQNLLKGK 849
ELK I E + I K++E E+LK N++K ++ + K+Q Q L + K
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 850 --------------EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 895
E Q+ +MKA LE K+K+L + ++ +EE ++L+ ++ +
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 896 LKEASSA-------------SQFEELEIVLKE-KENELKRLEAMLKERESD---LSSKTQ 938
L E SQ EE E K+ E+ L L L+ERE + L K +
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Query: 939 LLQDVQDENKLFKSQIEQLKQQNYQQASSFP-----PHEELLKVI----SEREKEISGLW 989
++ Q E + + + Q+ + +EE + V+ +E+EK + +
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756
Query: 990 NELDSLKDA--------------VEHQRKKNND-----------LREKNWEA-------- 1016
E + + +EH K ++ L EKN +
Sbjct: 1757 QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816
Query: 1017 --------MEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1068
++A + E + D V KT +E++ + +E + KE+ L + V +
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDD-VQKTLQEKELTCQILEQKIKELDSCLVRQKEV-HRVEM 1874
Query: 1069 GEWLHGFEK-KAKECMAGTSGSEEVKVLEHKLKEADEMHTL-------LQLECEKYKSVL 1120
E +EK +A + M G + E+ LE +E + H + ++ + + L
Sbjct: 1875 EELTSKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKL 1932
Query: 1121 AETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE--- 1177
A E QKL + + + + ++ E + ++ ++ + +E +++ E +D+E
Sbjct: 1933 AGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREE--KIKQEQEDLELKH 1990
Query: 1178 -----NLRRE-REHLEMELEKAEMERSTYVTEVRELKAQL--------NETLTKLRTEQN 1223
L RE L + ++ EM + + +E++A+L N+ L K+ + +
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 1224 ERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM---SVSLNQT 1280
+ ++ A + + E + K T +E + + ++E +V++ +
Sbjct: 2051 DLKRTAKRYEEILDARE--EEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
Query: 1281 VTQLQQLLQAVNQQLTKEKE 1300
TQL Q ++ KE+E
Sbjct: 2109 QTQLAQKTTLISDSKLKEQE 2128
Score = 148 bits (373), Expect = 4e-35
Identities = 281/1341 (20%), Positives = 573/1341 (42%), Gaps = 221/1341 (16%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVE- 93
++ + K K++ K + KK +++ KKE++N L S E L A A
Sbjct: 953 EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012
Query: 94 --DDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQ 151
D V+ + N E S+ E ++E + E+ + + ++++ + +
Sbjct: 1013 GISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ------AEELQEIHEIQL 1066
Query: 152 PTPPSEAAASKKKP---GQKKSKNGSD---------DQDKKVETLMVPSKRQEALP---L 196
E A K+K G +K + + QD + L K++ A
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 197 HQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK 256
ETK ++ K + K EN F+ E L+ + ++ D V E+ LK
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE----LKMLAEEDKRKV---SELTSKLK 1179
Query: 257 PDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQ 316
E + LK+ +K N ++ K SL+ SE+ A+ +D+ +K+
Sbjct: 1180 TTDEE------FQSLKSSHEKSNKSLEDK----SLEFKKLSEELAI-QLDICCKKT---- 1224
Query: 317 DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK-DRCKQLTQEMMTEKERSNVVITR 375
+AL ++ EL + ++ K +A ++ C+ T ++ ++
Sbjct: 1225 EALLEAKTNELINI-----------SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 376 MKDRIGTLEKEHNVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
++ ++ L +E QN +++S+Q+ T Q++ K Q++ M+A+I L E L+
Sbjct: 1274 LEAQLRQLTEE----QNTLNISFQQATHQLEEKENQIKS-MKADIESLVTEKEALQKEGG 1328
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAE 494
N K+S + +L+++ + +N +T +L++++V+ + + T L VQLQ +
Sbjct: 1329 NQQQAASEKESC-ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 495 RRWEEVQ--SYIRKRTAEHEAAQ----QDL------------------------------ 518
E+ S +RK+ E + QDL
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 519 --QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ-RLMQLMESEQKRVNKE-ESLQMQVQDI 574
QS+F +N V+ L +L L SK+ E+ + L++ E + NK + L+ +++D
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLE--LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 575 LEQNEALKAQIQ-QFHSQIAAQ-------TSASVLAEELHKVIAE--KDKQIKQTE---- 620
+ E ++ ++ + SQ A T ++ E L++V+ + K I+ E
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 621 ----DSLASERD-RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675
L E+D R+ EE++ ++N + +KAE++ + ELE + SV
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK----------ELEHVNLSV 1615
Query: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQN-KALKSEVQKLQTLVSEQPNKDV---VE 731
K+++++ LE++L+ E + K+ E K +Q A+K ++ EQ K +
Sbjct: 1616 KSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
++ +QE++ ++ +EE L++ ++ + E + +N + E ++ ++ Q +
Sbjct: 1676 ELNTKLQEREREVHILEEKLKS--VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEE 851
+ + L++ + EK+ ++ V + KE+TV + Q + L+K
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQ----------EKEETVSSHFEMRCQYQERLIK---- 1779
Query: 852 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS---------A 902
++ ++ +D + G ++L+E+N K + VAQH KE
Sbjct: 1780 ----LEHAEAKQHEDQSMIGHLQEELEEKN---KKYSLIVAQHVEKEGGKNNIQAKQNLE 1832
Query: 903 SQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNY 962
+ F++++ L+EKE + LE +KE +S L + ++ + +E S+ E+L Q
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE---LTSKYEKL--QAL 1887
Query: 963 QQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA---MEA 1019
QQ ELL+ +E + + + +L S +A ++NDL K A +
Sbjct: 1888 QQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEA------QHNDLEFKLAGAEREKQK 1941
Query: 1020 LASTEKMLQDKVNKTSKERQQQVEAV----ELEAKEVLKKLFPKVSVPSNLSYGEWLHGF 1075
L LQ + KE QQ++E + + E +E +K+ + + N + + + F
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001
Query: 1076 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1135
T +++ + LE +KE ++ ++E E +S ET +L+K+
Sbjct: 2002 ---------NTQLAQKEQELEMTIKET--INKAQEVEAELLESHQEETNQLLKKIAE--- 2047
Query: 1136 QEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRREREHLEMELEKAE 1194
K D+ +T K+ + + E+E+ ++R +E L+++ + +LE+ E
Sbjct: 2048 --------KDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK---YQQKLEQEE 2096
Query: 1195 MERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTT 1254
+ VT + EL+ QL + T + + + Q+ +H + L+ + + T
Sbjct: 2097 NPGNDNVT-IMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTP 2155
Query: 1255 V----IENSDVSPETESSEKE 1271
+ ++DVS E +E E
Sbjct: 2156 YKGGNLYHTDVSLFGEPTEFE 2176
Score = 105 bits (263), Expect = 2e-22
Identities = 178/874 (20%), Positives = 375/874 (42%), Gaps = 114/874 (13%)
Query: 455 YARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA 514
+ +L +++E+ +LQQ + + ++T +++ + + + + + + + ++
Sbjct: 2 FKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSF 61
Query: 515 QQDLQSKFVAKENEVQS------LHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568
Q LQ + + E+ +S S ++LV E ++S + +
Sbjct: 62 AQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMD 121
Query: 569 MQVQDILEQNEALKAQ--IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
+ +D++ +++L + IQ+ + +S EL ++ K+ + L+
Sbjct: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE 686
+D+ + EL++ M+ K +Q E+ A+ LE+ Q + V ++ LL+
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQ-------EEFDAS--LEEKDQYISVLQTQVSLLK 232
Query: 687 EQLQHEISNK--MEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQ--MEKCIQEKDE 742
++L++ N ++ L Q + E E + VVE K ++ +
Sbjct: 233 QRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP------ESDGEPVVEDGTSVKTLETLQQ 286
Query: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802
++K E LL+ + + +E+ + +E +L +++ D + ++ +++ + E+ K +
Sbjct: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL-DERLQELEKIKDLHMAEKTKLI 345
Query: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEE 862
+D K L++ ++K + ++ T + ++ L+ KEE++ A L
Sbjct: 346 TQLRDAK----------NLIEQLEQDKGMVIAETKR--QMHETLEMKEEEI----AQLRS 389
Query: 863 KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA-SSASQFEELEIVLK-EKENELK 920
+ K + G+ L++ +E++E A L++A S+A + EE LK E + ++K
Sbjct: 390 RIKQMTTQGEELREQKEKSE-------RAAFEELEKALSTAQKTEEARRKLKAEMDEQIK 442
Query: 921 RLEAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEELLKVI 978
+E +E L + +++ Q+V D K KS EQ+ K Q + +EL K +
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMK--KSSEEQIAKLQKLHEKELARKEQELTKKL 500
Query: 979 SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1038
RE+E + +K A+E + + + ++ E E+LA E LQ K T E
Sbjct: 501 QTREREFQ------EQMKVALEKSQSEYLKISQEK-EQQESLALEELELQKKAILTESEN 553
Query: 1039 -----QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1093
QQ+ E E+ L + N S +H +K K ++E+
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH-------NKEIT 606
Query: 1094 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT-I 1152
V+ K K +LE K++ TE LQ L++ + E K + K ++ +T +
Sbjct: 607 VMVEKHK--------TELESLKHQQDALWTEK-LQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 1153 KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLN 1212
K + F + +E+ E D++ + E E L EL + R E+ LK Q +
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVK--QTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 1213 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1272
+ +L + +E++ H QQ ++I+ +VS + +EK
Sbjct: 716 KMKQELEAKMDEQKN-----HHQQQV--------------DSIIKEHEVS--IQRTEK-- 752
Query: 1273 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+L + QL+ LL+ ++ L + + H + LE
Sbjct: 753 ---ALKDQINQLELLLKERDKHLKEHQAHVENLE 783
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 161 bits (408), Expect = 3e-39
Identities = 237/1072 (22%), Positives = 460/1072 (42%), Gaps = 118/1072 (11%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 921 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1025
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1146 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1263 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1319
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN + ++L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQL-SITSKVQELQNLLKGKEEQMNTMK 857
L D K K + E L+ K ++ ++T + +E E+ N ++
Sbjct: 1380 LS------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 858 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 917
L++ DL N + + +L+++ Q +A+ + A + + E +EKE
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 918 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 977
+ L L+E L +K +L + NK+ K+++E L + EL K
Sbjct: 1491 KALSLARALEEA---LEAKEEL----ERTNKMLKAEMEDLVSSKDDVGKNV---HELEKS 1540
Query: 978 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNWEAMEALASTEKMLQDKVNKTSK 1036
E ++ + +L+ L+D E Q ++ LR E N +A++ + +D+ N+ +
Sbjct: 1541 KRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 1037 ER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS------ 1089
+ Q+Q+ E E ++ K+ + L G+ L E +A + G +
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLE-GD-LKDLELQADSAIKGREEAIKQLRK 1656
Query: 1090 --EEVKVLEHKLKEA----DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1143
++K + +L++A DE+ + +K KS+ A+ L +LQ + E K
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD----LMQLQEDLAAAERARKQ 1712
Query: 1144 KVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTE 1203
E + +++ SS + L+ E + +E LE ELE+ +
Sbjct: 1713 ADLEKEELAEELASSLSGRNA----LQDEKRRLE---ARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1204 VRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV-- 1255
VR+ Q + +L TE++ QK + ++ + ++SK+ VK+ +T+
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1256 ----IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
I + E E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1876
Score = 153 bits (387), Expect = 9e-37
Identities = 254/1199 (21%), Positives = 488/1199 (40%), Gaps = 174/1199 (14%)
Query: 114 RKKKEKKQKPVLEEQVIKESDASKIPGK---------KVEPV-PVTKQPTP--PSEAAAS 161
RK K+Q+ + +VI+ + A+ + + KV+P+ VT+Q E
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKKKASSKKQKTEN 220
K K Q+K++N + ++K L QE L E E+ + + ++KKQ+ E
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
+ +H + + +R+ + D E +++ + K + +K A
Sbjct: 930 I------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
E K K EDE L + D + S + L + +LTT + + +EK K
Sbjct: 984 EAKIKKL----------EDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 341 LAAVKEDAAATKDRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
L +K ++ + + E+ + ++E+S + ++K + LE + + F +I
Sbjct: 1032 LTKLK-------NKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQIADL 1081
Query: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
+ +++M+ + E+++A +A L E ++ N L+ ++ +L +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDE-------IAQKNNALK-----KIRELEGHISD 1129
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD 517
L +L + + E QK++ + LK +L++ Q KR E ++
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 518 LQSKFVAKENEVQSL---HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES-------- 566
L + + E +VQ + H++ + L + + +R ++ ++ + KE +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDK---QIKQTEDS 622
L Q++ + + L+AQ+Q+ S+ + + + + L +++HK+ E + + + E
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ S +L+D Q + L + QKL + +LE+ + S
Sbjct: 1310 AIKLAKDVASLSSQLQDTQEL--LQEETRQKLNV-----STKLRQLEEERNS-------- 1354
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS-----EQPNKDVVEQMEKCI 737
L++QL E+ K + ++ N L +KLQ S E+ K +++E
Sbjct: 1355 --LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Q+ +EK ++L +T ++EL+ + + + + V +L+ KQ F L+
Sbjct: 1413 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKKQR---KFDQLLA 1465
Query: 798 ELKKV--------------IHEKDGKI----KSVEELLEA-ELLKVANKEKTVQLS--IT 836
E K + EK+ K +++EE LEA E L+ NK ++ ++
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 837 SK------VQELQNLLKGKEEQMNTMKAVLEEKEKDLANT---------------GKWLQ 875
SK V EL+ + E QM MK LEE E +L T G++ +
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 876 DLQ---EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERES 931
DLQ E+NE + +Q E + L K+K E +LK LE
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
+ L+ +Q + K F+ ++E + +E+ E EK+ L +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASR----------DEIFATAKENEKKAKSLEAD 1695
Query: 992 LDSLKD---AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE 1048
L L++ A E RK+ + +E+ E + + S LQD+ + Q E +E E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 1049 A--KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA-DEM 1105
E + K + + E A E + LE + KE ++
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 1106 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1165
H + K+KS +A E + +L+ VEQE + + + K+++ E E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1166 LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1224
+ + E + L+ +LE+AE E R+L+ +L+E TE NE
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-----TESNE 1922
Score = 122 bits (307), Expect = 2e-27
Identities = 153/747 (20%), Positives = 320/747 (42%), Gaps = 69/747 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 914 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 961
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 962 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---------------- 832
+ + EE K + + K +S+ LE L K + ++
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 833 -LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV-QE 890
+ +++ EL+ L KEE++ A L+++ N K +++L+ L+ + E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 891 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF 950
A N E EELE + E E+ L + R T L + + +E +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 951 KSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNELDSLKDAV 999
++Q+++++Q++ Q E K + + +++G L K V
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 1000 EHQRKK----NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
EH++KK +L+ K + A A L DKV+K E + + + +K
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAG--TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
S+ S L + L E + K ++ EE L+ +L E E L+
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 1114 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
L++++ LQ +V E+ + +++ +++ + ++ +++ E+ RL+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 1171 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1230
E D+ + L LEK + + + E + + ++ + + E E++ A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 1231 DLHKA-QQSLELIQ-----SKIVKAAGDTTVIENSDVSPETESSE--KETMSVSLNQTVT 1282
L +A +++LE + +K++KA + V DV E K + + + T
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 1283 QLQQL---LQAVNQQLTKEKEHYQVLE 1306
QL++L LQA + + + Q L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALK 1580
Score = 110 bits (274), Expect = 1e-23
Identities = 210/1054 (19%), Positives = 433/1054 (41%), Gaps = 142/1054 (13%)
Query: 63 KKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV---VETSSSVRERKKKEK 119
KK+E++ LHE ++ + + L E ++A L++ +E + R++ + EK
Sbjct: 923 KKQELEE-ILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 120 -----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG 173
K K + +E ++ + +K+ +K+ ++ T +E K + K+K+
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 174 SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK-----ASSKKQKTENVFVDEPLI 228
S + +V RQE L ++ + ++ ++ A + K + +E L
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 229 HATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKEN-AEVKFKDF 287
A + + K + ++ ++EG + L +E N AE + +D
Sbjct: 1101 AALARL-------DDEIAQKNNALKKIR--ELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
L+ + ++ L S Q L+ + E+T L L E+ + A ++
Sbjct: 1152 GEELEALKTELEDTL--------DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
+ + E + + +R+ + + K TLEKE+ ++ V Q Q+++ K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQ---TLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 408 FQQVREQ---MEAEIAHLKQENGILRDAVSNTTNQLES------KQSAELNKLRQDYARL 458
+++ Q ++++ + ++ L D V N++ES + + KL +D A L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
++L + LQ+E QK N QL EE ++ ++ + E A+Q+L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQL-----------EEERNSLQDQLDEEMEAKQNL 1369
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKE-ESLQMQVQD-- 573
E + +L+ +L+D SK++L+ ++ +E +KR KE E+L Q ++
Sbjct: 1370 -------ERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 574 -ILEQNEALKAQIQQFHSQIAAQT-SASVLAEELHKVIAEKDKQI---KQTEDSLASERD 628
++ E K ++QQ + + L L K + D+ + K A ERD
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 629 RLTS--KEEELK----------------DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
R + +E+E K +++ N +LKAE++ L + ++ HELEK
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
++++ + ++++ E+L+ E+ + L +ALK + ++ EQ N++
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ-NEEKR 1598
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTK----EVQDLKA 784
Q+++ + E + +L+ +E + L A K E +L + + S K ++ L+
Sbjct: 1599 RQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 785 KQNDQVSFASLVE-------ELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQLS 834
Q F +E E+ E + K KS+E L+ +L K L
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 835 ITSKVQELQNLLKGK---------------------EEQMNTMKAVLEEKEKDLANTGKW 873
+EL + L G+ EE+ M+A+ + K +
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 874 LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERESD 932
+L E + + + Q + S+ E+E +K K ++ + LEA + + E
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 933 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 992
+ + + Q K +++++ Q + ++E + + R K++
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK------ 1890
Query: 993 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM 1026
L++A E ++ N + R+ E EA S E M
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 73.2 bits (178), Expect = 2e-12
Identities = 137/690 (19%), Positives = 283/690 (41%), Gaps = 110/690 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1345 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1390
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1391 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1436
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1489
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1490 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1547 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1596 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1699
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1700 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1746
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1795
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1796 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1851 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
+LQ E+ E + + + ALKS+++
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 161 bits (408), Expect = 3e-39
Identities = 237/1072 (22%), Positives = 460/1072 (42%), Gaps = 118/1072 (11%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 914 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1018
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1139 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1256 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1312
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN + ++L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQL-SITSKVQELQNLLKGKEEQMNTMK 857
L D K K + E L+ K ++ ++T + +E E+ N ++
Sbjct: 1373 LS------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 858 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 917
L++ DL N + + +L+++ Q +A+ + A + + E +EKE
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 918 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 977
+ L L+E L +K +L + NK+ K+++E L + EL K
Sbjct: 1484 KALSLARALEEA---LEAKEEL----ERTNKMLKAEMEDLVSSKDDVGKNV---HELEKS 1533
Query: 978 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNWEAMEALASTEKMLQDKVNKTSK 1036
E ++ + +L+ L+D E Q ++ LR E N +A++ + +D+ N+ +
Sbjct: 1534 KRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 1037 ER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS------ 1089
+ Q+Q+ E E ++ K+ + L G+ L E +A + G +
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLE-GD-LKDLELQADSAIKGREEAIKQLRK 1649
Query: 1090 --EEVKVLEHKLKEA----DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1143
++K + +L++A DE+ + +K KS+ A+ L +LQ + E K
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD----LMQLQEDLAAAERARKQ 1705
Query: 1144 KVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTE 1203
E + +++ SS + L+ E + +E LE ELE+ +
Sbjct: 1706 ADLEKEELAEELASSLSGRNA----LQDEKRRLE---ARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1204 VRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV-- 1255
VR+ Q + +L TE++ QK + ++ + ++SK+ VK+ +T+
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1256 ----IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
I + E E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1869
Score = 153 bits (387), Expect = 9e-37
Identities = 254/1199 (21%), Positives = 488/1199 (40%), Gaps = 174/1199 (14%)
Query: 114 RKKKEKKQKPVLEEQVIKESDASKIPGK---------KVEPV-PVTKQPTP--PSEAAAS 161
RK K+Q+ + +VI+ + A+ + + KV+P+ VT+Q E
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKKKASSKKQKTEN 220
K K Q+K++N + ++K L QE L E E+ + + ++KKQ+ E
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
+ +H + + +R+ + D E +++ + K + +K A
Sbjct: 923 I------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
E K K EDE L + D + S + L + +LTT + + +EK K
Sbjct: 977 EAKIKKL----------EDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 341 LAAVKEDAAATKDRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
L +K ++ + + E+ + ++E+S + ++K + LE + + F +I
Sbjct: 1025 LTKLK-------NKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQIADL 1074
Query: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
+ +++M+ + E+++A +A L E ++ N L+ ++ +L +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDE-------IAQKNNALK-----KIRELEGHISD 1122
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD 517
L +L + + E QK++ + LK +L++ Q KR E ++
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 518 LQSKFVAKENEVQSL---HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES-------- 566
L + + E +VQ + H++ + L + + +R ++ ++ + KE +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDK---QIKQTEDS 622
L Q++ + + L+AQ+Q+ S+ + + + + L +++HK+ E + + + E
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ S +L+D Q + L + QKL + +LE+ + S
Sbjct: 1303 AIKLAKDVASLSSQLQDTQEL--LQEETRQKLNV-----STKLRQLEEERNS-------- 1347
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS-----EQPNKDVVEQMEKCI 737
L++QL E+ K + ++ N L +KLQ S E+ K +++E
Sbjct: 1348 --LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Q+ +EK ++L +T ++EL+ + + + + V +L+ KQ F L+
Sbjct: 1406 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKKQR---KFDQLLA 1458
Query: 798 ELKKV--------------IHEKDGKI----KSVEELLEA-ELLKVANKEKTVQLS--IT 836
E K + EK+ K +++EE LEA E L+ NK ++ ++
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 837 SK------VQELQNLLKGKEEQMNTMKAVLEEKEKDLANT---------------GKWLQ 875
SK V EL+ + E QM MK LEE E +L T G++ +
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 876 DLQ---EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERES 931
DLQ E+NE + +Q E + L K+K E +LK LE
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
+ L+ +Q + K F+ ++E + +E+ E EK+ L +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASR----------DEIFATAKENEKKAKSLEAD 1688
Query: 992 LDSLKD---AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE 1048
L L++ A E RK+ + +E+ E + + S LQD+ + Q E +E E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 1049 A--KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA-DEM 1105
E + K + + E A E + LE + KE ++
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 1106 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1165
H + K+KS +A E + +L+ VEQE + + + K+++ E E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1166 LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1224
+ + E + L+ +LE+AE E R+L+ +L+E TE NE
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-----TESNE 1915
Score = 122 bits (307), Expect = 2e-27
Identities = 153/747 (20%), Positives = 320/747 (42%), Gaps = 69/747 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 907 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 954
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 955 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---------------- 832
+ + EE K + + K +S+ LE L K + ++
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 833 -LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV-QE 890
+ +++ EL+ L KEE++ A L+++ N K +++L+ L+ + E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 891 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF 950
A N E EELE + E E+ L + R T L + + +E +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 951 KSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNELDSLKDAV 999
++Q+++++Q++ Q E K + + +++G L K V
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 1000 EHQRKK----NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
EH++KK +L+ K + A A L DKV+K E + + + +K
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAG--TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
S+ S L + L E + K ++ EE L+ +L E E L+
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 1114 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
L++++ LQ +V E+ + +++ +++ + ++ +++ E+ RL+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 1171 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1230
E D+ + L LEK + + + E + + ++ + + E E++ A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 1231 DLHKA-QQSLELIQ-----SKIVKAAGDTTVIENSDVSPETESSE--KETMSVSLNQTVT 1282
L +A +++LE + +K++KA + V DV E K + + + T
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 1283 QLQQL---LQAVNQQLTKEKEHYQVLE 1306
QL++L LQA + + + Q L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALK 1573
Score = 110 bits (274), Expect = 1e-23
Identities = 210/1054 (19%), Positives = 433/1054 (41%), Gaps = 142/1054 (13%)
Query: 63 KKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV---VETSSSVRERKKKEK 119
KK+E++ LHE ++ + + L E ++A L++ +E + R++ + EK
Sbjct: 916 KKQELEE-ILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 120 -----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG 173
K K + +E ++ + +K+ +K+ ++ T +E K + K+K+
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 174 SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK-----ASSKKQKTENVFVDEPLI 228
S + +V RQE L ++ + ++ ++ A + K + +E L
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 229 HATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKEN-AEVKFKDF 287
A + + K + ++ ++EG + L +E N AE + +D
Sbjct: 1094 AALARL-------DDEIAQKNNALKKIR--ELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
L+ + ++ L S Q L+ + E+T L L E+ + A ++
Sbjct: 1145 GEELEALKTELEDTL--------DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
+ + E + + +R+ + + K TLEKE+ ++ V Q Q+++ K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQ---TLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 408 FQQVREQ---MEAEIAHLKQENGILRDAVSNTTNQLES------KQSAELNKLRQDYARL 458
+++ Q ++++ + ++ L D V N++ES + + KL +D A L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
++L + LQ+E QK N QL EE ++ ++ + E A+Q+L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQL-----------EEERNSLQDQLDEEMEAKQNL 1362
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKE-ESLQMQVQD-- 573
E + +L+ +L+D SK++L+ ++ +E +KR KE E+L Q ++
Sbjct: 1363 -------ERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 574 -ILEQNEALKAQIQQFHSQIAAQT-SASVLAEELHKVIAEKDKQI---KQTEDSLASERD 628
++ E K ++QQ + + L L K + D+ + K A ERD
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 629 RLTS--KEEELK----------------DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
R + +E+E K +++ N +LKAE++ L + ++ HELEK
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
++++ + ++++ E+L+ E+ + L +ALK + ++ EQ N++
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ-NEEKR 1591
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTK----EVQDLKA 784
Q+++ + E + +L+ +E + L A K E +L + + S K ++ L+
Sbjct: 1592 RQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 785 KQNDQVSFASLVE-------ELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQLS 834
Q F +E E+ E + K KS+E L+ +L K L
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 835 ITSKVQELQNLLKGK---------------------EEQMNTMKAVLEEKEKDLANTGKW 873
+EL + L G+ EE+ M+A+ + K +
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 874 LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERESD 932
+L E + + + Q + S+ E+E +K K ++ + LEA + + E
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 933 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 992
+ + + Q K +++++ Q + ++E + + R K++
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK------ 1883
Query: 993 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM 1026
L++A E ++ N + R+ E EA S E M
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 73.2 bits (178), Expect = 2e-12
Identities = 137/690 (19%), Positives = 283/690 (41%), Gaps = 110/690 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1338 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1383
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1384 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1429
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1482
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1483 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1540 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1589 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1692
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1693 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1739
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1788
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1789 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1844 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
+LQ E+ E + + + ALKS+++
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 160 bits (406), Expect = 6e-39
Identities = 230/1100 (20%), Positives = 473/1100 (43%), Gaps = 136/1100 (12%)
Query: 298 EDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DAAATK 352
++E L V + + G +++ +K + E L QLQ + +L A +E AA K
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 353 DRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQ 409
+++ ++ + E+E N ++ K ++ ++ ++ + Q+ Q ++ +
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 410 QVREQMEAEIAHLKQENG-------ILRDAVSNTTNQL--ESKQSAELNKLRQDYARLVN 460
++ME EI L+ +N ++ D ++ ++QL E +++ L K+R +++
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
+L E+ L++EE ++ E+A +L + + + + E+Q+ I + + +++LQ
Sbjct: 1038 DLEER---LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQG 1094
Query: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580
++E +LH + L ++L+ ++ +L E + + Q +D+ E+ EA
Sbjct: 1095 ALARGDDE--TLHKN--NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 581 LKAQIQQFHSQIAAQTSASVLAE----ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEE 636
LK +++ AAQ E EL K + E + K E + R R + EE
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATALEE 1207
Query: 637 LKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
L + KA ++K Q L + A E++ +QQ + K + L+ Q+Q E+
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ-ELHA 1266
Query: 696 KMEEFKILN----DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
K+ E L ++ L++E+ + TL+ E K + + K + +L+ +ELL
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI--KFAKDAASLESQLQDTQELL 1324
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLK-AKQNDQVSFASLVEEL---KKVIHEKD 807
+ Q + + E +SL ++ ++ + A++N + +L +L KK + +
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Query: 808 GKIKSVEE-----LLEAELLKVANKEKTVQLSITSKV-----QELQNLLKGKEEQMNTMK 857
G I+S+EE L +AE L +EK + K QEL +L + Q +
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ-VA 1443
Query: 858 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQE----VAQHNLKEASSASQFEELEIVLK 913
+ LE+K+K K+ Q L EE + +E A+ KE + S LE L+
Sbjct: 1444 SNLEKKQK------KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497
Query: 914 EKENELKRLEAMLKERESDLSSKTQL---LQDVQDENKLFKSQIEQLKQQNYQQASSFPP 970
KE ++ + + + E +SSK + + +++ + + Q+E+++ Q +
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 971 HEEL----------LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1020
E+ +K ER+ + NE + + ++ R+ +L ++ + A+
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNE-EKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 1021 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1080
AS +KM D K+ + Q+EA EV+K+L + Y L
Sbjct: 1617 ASKKKMEIDL-----KDLEAQIEAANKARDEVIKQL--RKLQAQMKDYQRELEEARASRD 1669
Query: 1081 ECMAGTSGSE------EVKVLE-------------HKLKEADEMHTLLQLECEKYKSVLA 1121
E A + SE E ++L+ H +E DE+ + ++L
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729
Query: 1122 ET---EGILQKLQRSVEQEENKWKVKVDESHKTIKQM----------QSSFTSSEQELER 1168
E E + +L+ +E+E++ ++ D KT Q+ +S+ S+ ++
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789
Query: 1169 LRSENKDIENLRRERE-------------------HLEMELEKAEMERSTYVTEVRELKA 1209
L +NK+++ +E E LE +LE+ ER+ VR +
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 1210 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1269
+L E ++ E+ + + KA ++ ++ ++ +A + T S + E +
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 1270 KETMSVSLNQTVTQLQQLLQ 1289
+ L++ V+ L+ L+
Sbjct: 1910 ATEANEGLSREVSTLKNRLR 1929
Score = 142 bits (358), Expect = 2e-33
Identities = 163/783 (20%), Positives = 362/783 (46%), Gaps = 73/783 (9%)
Query: 544 QQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAE 603
Q ++ L+++ E + K + E ++ + Q +LE+ L Q+Q A+T AE
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ-------AETELFAEAE 907
Query: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663
E+ +A K +++++ L S R+ +EE + +QN ++A +Q L+ +E+
Sbjct: 908 EMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 664 AAHELEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQ----NKALKSEVQK 716
A +K+Q + KI+ +EE+ L+ + S ++E K++ D+ + L E +K
Sbjct: 965 AR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 717 LQTLVSEQPNKDV--------VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI 768
+ L + ++V +++ EK QE ++ + ++ Q+A + +++ +
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 769 RTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE 828
+ + + +E+Q A+ +D+ + KV+ E +I ++E E+E NK
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKN---NALKVVRELQAQIAELQEDFESEKAS-RNKA 1137
Query: 829 KTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 888
+ + ++ +++ L+ L E+ ++T A E + K + + L+EE ++ +A +
Sbjct: 1138 EKQKRDLSEELEALKTEL---EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 889 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 948
Q++ Q + S E+LE + K N L++ + L+ +L+ + ++LQ V+ E++
Sbjct: 1195 QDMRQRHATALEELS--EQLEQAKRFKAN-LEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 949 LFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNND 1008
+ +++ Q+ + + S + L+V E ++ S L NELD++ +E KK
Sbjct: 1252 HKRKKLDAQVQELHAKVS----EGDRLRV--ELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 1009 LREKNWEAMEALASTEKMLQD----KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS 1064
+ L T+++LQ+ K+N +S+ RQ + E L+ ++ ++ K
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 1065 NLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETE 1124
L+ L +KK + + EE K + LK+A+ + L+ + Y
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDK------ 1417
Query: 1125 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE-NLRRER 1183
L+K + ++QE + V +D +Q+ S+ +++ ++L +E K I ER
Sbjct: 1418 --LEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 1184 EHLEMELEKAE---MERSTYVTEVRELKAQLNETLTKLRTEQNE----RQKVAGDLHKAQ 1236
+ E E + E + + + E E K + +LR + + + V ++H+ +
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 1237 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLT 1296
+S ++ ++ + T +E + + K + V++ Q ++ LQ ++Q
Sbjct: 1532 KSKRALEQQVEEM---RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 1297 KEK 1299
++K
Sbjct: 1589 EKK 1591
Score = 99.0 bits (245), Expect = 3e-20
Identities = 129/571 (22%), Positives = 256/571 (44%), Gaps = 70/571 (12%)
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
L+QV +EEEL A K+ + LK K+ Q +EE+++ + + +
Sbjct: 844 LLQVTRQEEELQA---------KDEELLKVKEK-QTKVEGELEEMERKHQQLLEEKNILA 893
Query: 815 ELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 874
E L+AE A E+ ++ + +K QEL+ +L E ++ EE+E++
Sbjct: 894 EQLQAETELFAEAEE-MRARLAAKKQELEEILHDLESRVE------EEEERN-------- 938
Query: 875 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEA---MLKERES 931
Q LQ E + ++AH+Q++ + L E A Q +LE V E + +K++E +L+++ S
Sbjct: 939 QILQNEKKKMQAHIQDL-EEQLDEEEGARQKLQLEKVTAEAK--IKKMEEEILLLEDQNS 995
Query: 932 DLSSKTQLLQD-VQDENKLFKSQIEQLKQ----QNYQQASSFPPHEELLK---VISEREK 983
+ +L++D + + + + E+ K +N Q+ E L K E EK
Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 984 EISGLWNELDSLKDAVEHQRKKNNDLR----EKNWEAMEALASTEKMLQDKVNKTSKERQ 1039
L E L+D + + + ++L+ +K E ALA + K N R+
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 1040 QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL 1099
Q + EL+ +K + E L + + ++ + T+ +E++ +
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ- 1174
Query: 1100 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1159
E E+ L+ E + ++ A+ + + Q+ ++E+ + E + K+ +++
Sbjct: 1175 -EVAELKKALEEETKNHE---AQIQDMRQRHATALEE--------LSEQLEQAKRFKANL 1222
Query: 1160 TSSEQELE----RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETL 1215
++Q LE L E K ++ ++ E EH +L+ E V+E L+ +L E
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 1216 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1275
+KL QNE V+ L +A++ K +K A D +E+ + E+ +
Sbjct: 1283 SKL---QNELDNVSTLLEEAEK-------KGIKFAKDAASLESQLQDTQELLQEETRQKL 1332
Query: 1276 SLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+L+ + QL++ ++ +Q +E+E + LE
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Score = 92.0 bits (227), Expect = 3e-18
Identities = 127/610 (20%), Positives = 260/610 (42%), Gaps = 78/610 (12%)
Query: 730 VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ---DLKAKQ 786
V + E+ +Q KDE+L V+E ++ E + + E + L +++Q +L A+
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 787 ND-QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNL 845
+ + A+ +EL++++H+ + +++ EE + + N++K +Q I ++L
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQI----LQNEKKKMQAHIQDLEEQLDEE 962
Query: 846 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ----EENESLKAHVQEVAQHNLKEASS 901
+G +++ K E K K + L+D +E + ++ + E + +E
Sbjct: 963 -EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 902 ASQFEEL----EIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957
A ++ E+++ + E LK+ E +E E D+QD+ ++QI++L
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 958 K------QQNYQQASSFPPHEEL-----LKVISEREKEISGLWNELDSLKDAVEHQRKKN 1006
K ++ Q A + E L LKV+ E + +I+ L + +S K + K+
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 1007 NDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNL 1066
DL E+ +EAL + L+D ++ T+ +++ + + E E E+ K L
Sbjct: 1142 RDLSEE----LEALKTE---LEDTLDTTAAQQELRTKR-EQEVAELKKALEE-------- 1185
Query: 1067 SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG- 1125
E K E LE +L E E + EK K L ET+
Sbjct: 1186 ---------ETKNHEAQIQDMRQRHATALE-ELSEQLEQAKRFKANLEKNKQGL-ETDNK 1234
Query: 1126 -------ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN 1178
+LQ+++ E + K +V E H + + ++ +L++E ++
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 1179 LRREREHLEMELEKAEMERSTYVTEVREL-------KAQLNETLTKLRTEQNERQKVAGD 1231
L E E ++ K + + + +EL K L+ + +L E+N Q+ +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 1232 LHKAQQSLE----LIQSKIV----KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQ 1283
+A+++LE +QS++ K D IE+ + + + + E +S L +
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 1284 LQQLLQAVNQ 1293
+L + N+
Sbjct: 1415 YDKLEKTKNR 1424
Score = 67.4 bits (163), Expect = 9e-11
Identities = 118/678 (17%), Positives = 259/678 (38%), Gaps = 74/678 (10%)
Query: 45 QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV 104
Q+L+ +T +K + ++ E + +L E E L + Q+A V
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 105 VE---TSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAAS 161
+ T S+ E KKK K L +++ +++ A + + TK +
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA-------YDKLEKTKNRLQQELDDLT 1433
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENV 221
Q++ + + + KK + L+ K A + + E A +++++T+ +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE-------AEAREKETKAL 1486
Query: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAE 281
+ L A + + D +++ K D + + + K E E
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 282 VKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLL 341
+ ++ EDE D K + V A+K + +L T Q +EK +LL
Sbjct: 1546 TQLEEL----------EDELQATEDA-KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 342 -AAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
V+E A +D KQ + K++ + + ++ +I K + ++ +
Sbjct: 1595 IKQVRELEAELEDERKQRAL-AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK--LRQDYARL 458
+ Q + ++ R + A K+ L+ + E S+E + Q+ L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
+E+T +K+ E QL+ +L+E + E + RK T
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL--------- 1764
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN 578
+V +L+++L +E+ K ++ + Q++ QN
Sbjct: 1765 ---------QVDTLNAELA------------------AERSAAQKSDNARQQLE---RQN 1794
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+ LKA++Q+ + ++ A++ A L I + ++Q++Q A+ + E++LK
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISA--LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
+I + + + + A +L++ + + + +LQ E+ + E
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Query: 699 EFKILNDQNKALKSEVQK 716
+ L+ + LK+ +++
Sbjct: 1913 ANEGLSREVSTLKNRLRR 1930
Score = 53.1 bits (126), Expect = 2e-06
Identities = 57/278 (20%), Positives = 122/278 (43%), Gaps = 31/278 (11%)
Query: 1033 KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV 1092
K ++QQQ+ A LK L + L + +W F K K + T EE+
Sbjct: 804 KAFAKKQQQLSA--------LKVLQRNCAAYLKLRHWQWWRVFTK-VKPLLQVTRQEEEL 854
Query: 1093 KVLEHKLKEADEMHTLLQLECE----KYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1148
+ + +L + E T ++ E E K++ +L E + ++LQ E
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL------------ 902
Query: 1149 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK 1208
++M++ + +QELE + D+E+ E E L+ E+ +++L+
Sbjct: 903 FAEAEEMRARLAAKKQELEEILH---DLESRVEEEEERNQILQN---EKKKMQAHIQDLE 956
Query: 1209 AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESS 1268
QL+E + Q E+ + K ++ + L++ + K + ++E+ ++ +
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 1269 EKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
E+E + +L + + + ++ + ++L KE++ Q LE
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 159 bits (402), Expect = 2e-38
Identities = 265/1255 (21%), Positives = 508/1255 (40%), Gaps = 177/1255 (14%)
Query: 114 RKKKEKKQKPVLEEQVIKESDASKIPGK---------KVEPV-PVTKQPTP--PSEAAAS 161
RK K+Q+ + +VI+ + A+ + + KV+P+ VT+Q E
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKKKASSKKQKTEN 220
K K Q+K++N + ++K L QE L E E+ + + ++KKQ+ E
Sbjct: 863 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
+ +H + + +R+ + D E +++ + K + +K A
Sbjct: 923 I------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
E K K EDE L + D + S + L + +LTT + + +EK K
Sbjct: 977 EAKIKKL----------EDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 341 LAAVKEDAAATKDRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
L +K ++ + + E+ + ++E+S + ++K + LE + + F +I
Sbjct: 1025 LTKLK-------NKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQIADL 1074
Query: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
+ +++M+ + E+++A +A L E ++ N L+ ++ +L +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDE-------IAQKNNALK-----KIRELEGHISD 1122
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD 517
L +L + + E QK++ + LK +L++ Q KR E ++
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 518 LQSKFVAKENEVQSL---HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES-------- 566
L + + E +VQ + H++ + L + + +R ++ ++ + KE +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDK---QIKQTEDS 622
L Q++ + + L+AQ+Q+ S+ + + + + L +++HK+ E + + + E
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ S +L+D Q + L + QKL + +LE+ + S
Sbjct: 1303 AIKLAKDVASLSSQLQDTQEL--LQEETRQKLNV-----STKLRQLEEERNS-------- 1347
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS-----EQPNKDVVEQMEKCI 737
L++QL E+ K + ++ N L +KLQ S E+ K +++E
Sbjct: 1348 --LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Q+ +EK ++L +T ++EL+ + + + + V +L+ KQ F L+
Sbjct: 1406 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKKQR---KFDQLLA 1458
Query: 798 ELKKV--------------IHEKDGKI----KSVEELLEA-ELLKVANKEKTVQLS--IT 836
E K + EK+ K +++EE LEA E L+ NK ++ ++
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 837 SK------VQELQNLLKGKEEQMNTMKAVLEEKEKDLANT---------------GKWLQ 875
SK V EL+ + E QM MK LEE E +L T G++ +
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 876 DLQ---EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERES 931
DLQ E+NE + +Q E + L K+K E +LK LE
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
+ L+ +Q + K F+ ++E + +E+ E EK+ L +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASR----------DEIFATAKENEKKAKSLEAD 1688
Query: 992 LDSLKD---AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE 1048
L L++ A E RK+ + +E+ E + + S LQD+ + Q E +E E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 1049 A--KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA-DEM 1105
E + K + + E A E + LE + KE ++
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 1106 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1165
H + K+KS +A E + +L+ VEQE + + + K+++ E E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1166 LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNER 1225
+ + E + L+ +LE+AE E R+L+ +L+E E
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 1226 QKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQT 1280
+ L + ++ + S + +G VIEN+D S E E +T N T
Sbjct: 1922 NALKSKLRRGNET-SFVPS---RRSGGRRVIENADGSEE----ETDTRDADFNGT 1968
Score = 122 bits (307), Expect = 2e-27
Identities = 153/747 (20%), Positives = 320/747 (42%), Gaps = 69/747 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 907 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 954
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 955 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---------------- 832
+ + EE K + + K +S+ LE L K + ++
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 833 -LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV-QE 890
+ +++ EL+ L KEE++ A L+++ N K +++L+ L+ + E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 891 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF 950
A N E EELE + E E+ L + R T L + + +E +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 951 KSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNELDSLKDAV 999
++Q+++++Q++ Q E K + + +++G L K V
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 1000 EHQRKK----NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
EH++KK +L+ K + A A L DKV+K E + + + +K
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAG--TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
S+ S L + L E + K ++ EE L+ +L E E L+
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Query: 1114 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
L++++ LQ +V E+ + +++ +++ + ++ +++ E+ RL+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 1171 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1230
E D+ + L LEK + + + E + + ++ + + E E++ A
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 1231 DLHKA-QQSLELIQ-----SKIVKAAGDTTVIENSDVSPETESSE--KETMSVSLNQTVT 1282
L +A +++LE + +K++KA + V DV E K + + + T
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 1283 QLQQL---LQAVNQQLTKEKEHYQVLE 1306
QL++L LQA + + + Q L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALK 1573
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1338 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1383
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1384 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1429
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1482
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1483 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1540 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1589 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1692
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1693 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1739
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1788
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1789 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1844 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 159 bits (402), Expect = 2e-38
Identities = 265/1255 (21%), Positives = 508/1255 (40%), Gaps = 177/1255 (14%)
Query: 114 RKKKEKKQKPVLEEQVIKESDASKIPGK---------KVEPV-PVTKQPTP--PSEAAAS 161
RK K+Q+ + +VI+ + A+ + + KV+P+ VT+Q E
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKKKASSKKQKTEN 220
K K Q+K++N + ++K L QE L E E+ + + ++KKQ+ E
Sbjct: 870 KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 221 VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENA 280
+ +H + + +R+ + D E +++ + K + +K A
Sbjct: 930 I------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 281 EVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKL 340
E K K EDE L + D + S + L + +LTT + + +EK K
Sbjct: 984 EAKIKKL----------EDEILVMDDQNNKLSK--ERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 341 LAAVKEDAAATKDRCKQLTQEM---MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
L +K ++ + + E+ + ++E+S + ++K + LE + + F +I
Sbjct: 1032 LTKLK-------NKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQIADL 1081
Query: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
+ +++M+ + E+++A +A L E ++ N L+ ++ +L +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDE-------IAQKNNALK-----KIRELEGHISD 1129
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD 517
L +L + + E QK++ + LK +L++ Q KR E ++
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 518 LQSKFVAKENEVQSL---HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES-------- 566
L + + E +VQ + H++ + L + + +R ++ ++ + KE +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDK---QIKQTEDS 622
L Q++ + + L+AQ+Q+ S+ + + + + L +++HK+ E + + + E
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ S +L+D Q + L + QKL + +LE+ + S
Sbjct: 1310 AIKLAKDVASLSSQLQDTQEL--LQEETRQKLNV-----STKLRQLEEERNS-------- 1354
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVS-----EQPNKDVVEQMEKCI 737
L++QL E+ K + ++ N L +KLQ S E+ K +++E
Sbjct: 1355 --LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
Q+ +EK ++L +T ++EL+ + + + + V +L+ KQ F L+
Sbjct: 1413 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKKQR---KFDQLLA 1465
Query: 798 ELKKV--------------IHEKDGKI----KSVEELLEA-ELLKVANKEKTVQLS--IT 836
E K + EK+ K +++EE LEA E L+ NK ++ ++
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 837 SK------VQELQNLLKGKEEQMNTMKAVLEEKEKDLANT---------------GKWLQ 875
SK V EL+ + E QM MK LEE E +L T G++ +
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 876 DLQ---EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAMLKERES 931
DLQ E+NE + +Q E + L K+K E +LK LE
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
+ L+ +Q + K F+ ++E + +E+ E EK+ L +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASR----------DEIFATAKENEKKAKSLEAD 1695
Query: 992 LDSLKD---AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELE 1048
L L++ A E RK+ + +E+ E + + S LQD+ + Q E +E E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 1049 A--KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA-DEM 1105
E + K + + E A E + LE + KE ++
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 1106 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1165
H + K+KS +A E + +L+ VEQE + + + K+++ E E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1166 LERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNER 1225
+ + E + L+ +LE+AE E R+L+ +L+E E
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 1226 QKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQT 1280
+ L + ++ + S + +G VIEN+D S E E +T N T
Sbjct: 1929 NALKSKLRRGNET-SFVPS---RRSGGRRVIENADGSEE----ETDTRDADFNGT 1975
Score = 122 bits (307), Expect = 2e-27
Identities = 153/747 (20%), Positives = 320/747 (42%), Gaps = 69/747 (9%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ED L ++R E ELK+++ + L E LQ + E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ E++ HE+ ++EE + D+ + L++E +K+ Q D
Sbjct: 914 EEMRVRLAAKKQEL----EEILHEMEARLEEEE---DRGQQLQAERKKM-----AQQMLD 961
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
+ EQ+E+ +E + +E++ T ++ E+E+ + +N+ L+KE + L+ + +D
Sbjct: 962 LEEQLEE--EEAARQKLQLEKV--TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---------------- 832
+ + EE K + + K +S+ LE L K + ++
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 833 -LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV-QE 890
+ +++ EL+ L KEE++ A L+++ N K +++L+ L+ + E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 891 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLF 950
A N E EELE + E E+ L + R T L + + +E +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 951 KSQIEQLKQQNYQQASSFPPHEELLK-----------VISEREKEISGLWNELDSLKDAV 999
++Q+++++Q++ Q E K + + +++G L K V
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 1000 EHQRKK----NNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
EH++KK +L+ K + A A L DKV+K E + + + +K
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAG--TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
S+ S L + L E + K ++ EE L+ +L E E L+
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Query: 1114 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
L++++ LQ +V E+ + +++ +++ + ++ +++ E+ RL+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 1171 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAG 1230
E D+ + L LEK + + + E + + ++ + + E E++ A
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 1231 DLHKA-QQSLELIQ-----SKIVKAAGDTTVIENSDVSPETESSE--KETMSVSLNQTVT 1282
L +A +++LE + +K++KA + V DV E K + + + T
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 1283 QLQQL---LQAVNQQLTKEKEHYQVLE 1306
QL++L LQA + + + Q L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALK 1580
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1345 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1390
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1391 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1436
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1489
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1490 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1547 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1596 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1699
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1700 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1746
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1795
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1796 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1851 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLRR 1937
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 159 bits (402), Expect = 2e-38
Identities = 208/1038 (20%), Positives = 457/1038 (44%), Gaps = 146/1038 (14%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ------------- 832
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 833 -------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG-------------- 871
++ K + +L +++ A LE +K+ + G
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 872 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E E+
Sbjct: 1499 DQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
L + + +Q E KS++++ + ++ + ++++ + + E
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA---E 1610
Query: 992 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE-LEAK 1050
+ S DA+ ++K DL E + A + L++ N + Q+ + L ++
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 1051 EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1110
E LK+ V +NL E ++ + + T S K+ E +L +A E LL
Sbjct: 1671 EDLKEQLAMVERRANLLQAE-----IEELRATLEQTERSR--KIAEQELLDASERVQLLH 1723
Query: 1111 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
+ + L T+ +KL+ + Q + + + + E+ ++ + + T + E L+
Sbjct: 1724 TQ----NTSLINTK---KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 1171 SENKDIENLRREREHLE-------MELEKAE-MERSTYVTEVRELKAQLNETLTKLRTEQ 1222
E +L R ++++E + L++AE + ++++L+A++ E ++ +EQ
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 1223 NERQKVAGDLHKAQQSLE 1240
+ L K ++ ++
Sbjct: 1837 KRNAEAVKGLRKHERRVK 1854
Score = 140 bits (354), Expect = 6e-33
Identities = 214/1143 (18%), Positives = 487/1143 (42%), Gaps = 142/1143 (12%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q+ K+ +K+++ E V L+ + L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 898
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 957
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 958 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E +SN +++E +Q+ + +L++ L
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFE-------ISNLQSKIEDEQALGI-QLQKKIKELQ 1118
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIKQTEDSLASERD 628
D+ E + K +++ + Q S EE ++I + Q + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+L KE + + ++++L+ E+ A + L QS D LL EQ
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD---LLREQ 1352
Query: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
+ E +K E + L+ N + K +T ++ E++E+ ++ ++L+ E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQAAE 1407
Query: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIH 804
E +E + A+ E+ ++ E L +V+ A Q +F ++ E K+
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 805 EKDGKIKSVEE---LLEAELLKVAN--------------KEKTVQLSITS---------- 837
E ++++ ++ L EL K+ N + K +Q I+
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ-------- 889
++ EL+ + K E++ ++A LEE E L + + +Q E +K+ V
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 890 ---EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERESDLSSKTQLLQDVQD 945
++ +++++ S + EI + LK+ +E L E E L+ ++ +
Sbjct: 1588 EIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL- 1646
Query: 946 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1005
+ +++ LK + E+L + ++ E+ + L E++ L+ +E +
Sbjct: 1647 --RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704
Query: 1006 NNDLREKNWEAME----------ALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
++ +A E +L +T+K L+ +++ E + ++ ++ K
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL-QLECE 1114
+ + L + ++ K+ M T VK L+ +L EA+++ + + +
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQT-----VKDLQLRLDEAEQLALKGGKKQIQ 1819
Query: 1115 KYKSVLAETEGILQKLQ----------RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
K ++ + E EG ++ Q R E+ + + +E K I ++Q +
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879
Query: 1165 ELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLR 1219
+++ + + ++ E NL + R+ L+ ELE+AE ++V +L+ + E TK+
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRK-LQHELEEAEERADIAESQVNKLRVKSREVHTKVI 1938
Query: 1220 TEQ 1222
+E+
Sbjct: 1939 SEE 1941
Score = 106 bits (264), Expect = 2e-22
Identities = 174/852 (20%), Positives = 368/852 (43%), Gaps = 119/852 (13%)
Query: 107 TSSSVRERKKKE---KKQKPVLEEQVIK-ESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
TS+ + KK+E +K + LEE ++ E+ A+ + K + V + + K
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1222
Query: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVF 222
+ + + K DD VET+ SK + L T ++ S K ++Q+ N
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETV---SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 223 VDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
+ T ++ + S +D++E + Q+ +++ T++++ + E+
Sbjct: 1280 TAQRGRLQT------ESGEFSRQLDEKEAL----VSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 283 KFKDFLL-SLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSS----------KGELTTLI 331
K K+ L +L++ D + +E +Q AL K++ + +
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 332 HQLQEKDKLLA----AVKEDAAATKDRCKQLT---QEMMTEKERSNVVITRMKDRIGTLE 384
+L+E K LA A +E A +C L Q + E E + + R L+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA---EIAHLKQENGILRDAVSNTTNQLE 441
K+ F +KI +++ K ++ ++EA E L E +++A + +QLE
Sbjct: 1450 KKQRNF-DKILAEWKQ------KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 442 SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ 501
+ + N L+Q+ + L ++ E ++ + E KK EQ +L+ L+EAE E +
Sbjct: 1503 TLKRENKN-LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
I + E + ++ K K+ E+ QL++ ++++ES Q +
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEID--------------QLKRNHIRIVESMQSTL 1607
Query: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQI--AAQTSASVLAEELHKVIAEKDKQIKQT 619
+ E + D + + ++ + + Q+ A + +A L + KD QI
Sbjct: 1608 DAEIRSR---NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI-HL 1663
Query: 620 EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
+D+L S+ D +E+L ++ LL+AE+++L+A LE+ ++S
Sbjct: 1664 DDALRSQEDL----KEQLAMVERRANLLQAEIEELRAT----------LEQTERS----- 1704
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
R + EQ E+ + E ++L+ QN +L + +KL+T +S+ +ME +QE
Sbjct: 1705 ---RKIAEQ---ELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-----EMEDILQE 1753
Query: 740 -KDEKLKTVEELLETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAKQNDQVSFASLV 796
++ + K + + + ++ K+E+ + E ++ + V+DL+ + ++ A +
Sbjct: 1754 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA--L 1811
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856
+ KK I + + +++ +E +E+E + A K L+ E ++ +
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG---------------LRKHERRVKEL 1856
Query: 857 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916
EE K++ + LQ + +S K +E + + ++ ++F +L+ L+E E
Sbjct: 1857 TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS---NTNLAKFRKLQHELEEAE 1913
Query: 917 NELKRLEAMLKE 928
E+ + +
Sbjct: 1914 ERADIAESQVNK 1925
Score = 87.4 bits (215), Expect = 8e-17
Identities = 115/602 (19%), Positives = 264/602 (43%), Gaps = 45/602 (7%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEK 829
L K L+AK + A EE+ + K K LE E ++
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-------LEDECSELKKDID 961
Query: 830 TVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN-ESLKAHV 888
++L++ +KV++ ++ + K + + A L+E L K LQ+ ++ + L+A
Sbjct: 962 DLELTL-AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1020
Query: 889 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 948
+V + Q ++LE L++++ LE ++ E DL + + D+++E
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE-- 1078
Query: 949 LFKSQI-EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN 1007
K Q+ E+LK++ ++ ++ E+ + + +K+I L ++ L++ +E +R
Sbjct: 1079 --KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 1008 DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1067
++ + L + L++ TS + + + E E +++ + L + L
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDL-----EEATLQ 1190
Query: 1068 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS---VLAETE 1124
+ KK + +A E++ L+ ++ ++ + +++E + S +++ +
Sbjct: 1191 HEATAATLRKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 1125 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE 1184
G L+K+ R++E + ++ K K +E + I + + + RL++E+ + E+E
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGEFSRQLDEKE 1301
Query: 1185 HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1244
L +L + + + ++ ELK QL E E + +A L ++ +L++
Sbjct: 1302 ALVSQLSRG---KQAFTQQIEELKRQLEE-------EIKAKNALAHALQSSRHDCDLLRE 1351
Query: 1245 KIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
+ + ++ + TE ++ T Q +L++ + + Q+L +EH +
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 1304 VL 1305
+
Sbjct: 1412 AV 1413
Score = 35.4 bits (80), Expect = 0.36
Identities = 39/221 (17%), Positives = 93/221 (42%), Gaps = 11/221 (4%)
Query: 1091 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1147
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 841 KIKPLLKSAETEKEMATMKE-EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1205
+ + + + +L ++ K++ + E + EL +K ++E E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECS 954
Query: 1206 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1265
ELK +++ L + E+ + + + + I K + ++ +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 1266 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 159 bits (402), Expect = 2e-38
Identities = 208/1038 (20%), Positives = 457/1038 (44%), Gaps = 146/1038 (14%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ------------- 832
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDV 1438
Query: 833 -------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG-------------- 871
++ K + +L +++ A LE +K+ + G
Sbjct: 1439 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 872 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E E+
Sbjct: 1499 DQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNE 991
L + + +Q E KS++++ + ++ + ++++ + + E
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA---E 1610
Query: 992 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE-LEAK 1050
+ S DA+ ++K DL E + A + L++ N + Q+ + L ++
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 1051 EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1110
E LK+ V +NL E ++ + + T S K+ E +L +A E LL
Sbjct: 1671 EDLKEQLAMVERRANLLQAE-----IEELRATLEQTERSR--KIAEQELLDASERVQLLH 1723
Query: 1111 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1170
+ + L T+ +KL+ + Q + + + + E+ ++ + + T + E L+
Sbjct: 1724 TQ----NTSLINTK---KKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 1171 SENKDIENLRREREHLE-------MELEKAE-MERSTYVTEVRELKAQLNETLTKLRTEQ 1222
E +L R ++++E + L++AE + ++++L+A++ E ++ +EQ
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836
Query: 1223 NERQKVAGDLHKAQQSLE 1240
+ L K ++ ++
Sbjct: 1837 KRNAEAVKGLRKHERRVK 1854
Score = 140 bits (354), Expect = 6e-33
Identities = 214/1143 (18%), Positives = 487/1143 (42%), Gaps = 142/1143 (12%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q+ K+ +K+++ E V L+ + L
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 898
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 957
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 958 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E +SN +++E +Q+ + +L++ L
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFE-------ISNLQSKIEDEQALGI-QLQKKIKELQ 1118
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIKQTEDSLASERD 628
D+ E + K +++ + Q S EE ++I + Q + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+L KE + + ++++L+ E+ A + L QS D LL EQ
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD---LLREQ 1352
Query: 689 LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE 748
+ E +K E + L+ N + K +T ++ E++E+ ++ ++L+ E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQAAE 1407
Query: 749 ELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKKVIH 804
E +E + A+ E+ ++ E L +V+ A Q +F ++ E K+
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 805 EKDGKIKSVEE---LLEAELLKVAN--------------KEKTVQLSITS---------- 837
E ++++ ++ L EL K+ N + K +Q I+
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 838 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ-------- 889
++ EL+ + K E++ ++A LEE E L + + +Q E +K+ V
Sbjct: 1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 890 ---EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERESDLSSKTQLLQDVQD 945
++ +++++ S + EI + LK+ +E L E E L+ ++ +
Sbjct: 1588 EIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL- 1646
Query: 946 ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1005
+ +++ LK + E+L + ++ E+ + L E++ L+ +E +
Sbjct: 1647 --RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704
Query: 1006 NNDLREKNWEAME----------ALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
++ +A E +L +T+K L+ +++ E + ++ ++ K
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL-QLECE 1114
+ + L + ++ K+ M T VK L+ +L EA+++ + + +
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQT-----VKDLQLRLDEAEQLALKGGKKQIQ 1819
Query: 1115 KYKSVLAETEGILQKLQ----------RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164
K ++ + E EG ++ Q R E+ + + +E K I ++Q +
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879
Query: 1165 ELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLR 1219
+++ + + ++ E NL + R+ L+ ELE+AE ++V +L+ + E TK+
Sbjct: 1880 KVKSYKRQAEEAEEQSNTNLAKFRK-LQHELEEAEERADIAESQVNKLRVKSREVHTKVI 1938
Query: 1220 TEQ 1222
+E+
Sbjct: 1939 SEE 1941
Score = 106 bits (264), Expect = 2e-22
Identities = 174/852 (20%), Positives = 368/852 (43%), Gaps = 119/852 (13%)
Query: 107 TSSSVRERKKKE---KKQKPVLEEQVIK-ESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
TS+ + KK+E +K + LEE ++ E+ A+ + K + V + + K
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1222
Query: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVF 222
+ + + K DD VET+ SK + L T ++ S K ++Q+ N
Sbjct: 1223 LEKEKSEMKMEIDDLASNVETV---SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 223 VDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEV 282
+ T ++ + S +D++E + Q+ +++ T++++ + E+
Sbjct: 1280 TAQRGRLQT------ESGEFSRQLDEKEAL----VSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 283 KFKDFLL-SLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSS----------KGELTTLI 331
K K+ L +L++ D + +E +Q AL K++ + +
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 332 HQLQEKDKLLA----AVKEDAAATKDRCKQLT---QEMMTEKERSNVVITRMKDRIGTLE 384
+L+E K LA A +E A +C L Q + E E + + R L+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA---EIAHLKQENGILRDAVSNTTNQLE 441
K+ F +KI +++ K ++ ++EA E L E +++A + +QLE
Sbjct: 1450 KKQRNF-DKILAEWKQ------KCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 442 SKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ 501
+ + N L+Q+ + L ++ E ++ + E KK EQ +L+ L+EAE E +
Sbjct: 1503 TLKRENKN-LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
I + E + ++ K K+ E+ QL++ ++++ES Q +
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEID--------------QLKRNHIRIVESMQSTL 1607
Query: 562 NKEESLQMQVQDILEQNEALKAQIQQFHSQI--AAQTSASVLAEELHKVIAEKDKQIKQT 619
+ E + D + + ++ + + Q+ A + +A L + KD QI
Sbjct: 1608 DAEIRSR---NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI-HL 1663
Query: 620 EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
+D+L S+ D +E+L ++ LL+AE+++L+A LE+ ++S
Sbjct: 1664 DDALRSQEDL----KEQLAMVERRANLLQAEIEELRAT----------LEQTERS----- 1704
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
R + EQ E+ + E ++L+ QN +L + +KL+T +S+ +ME +QE
Sbjct: 1705 ---RKIAEQ---ELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-----EMEDILQE 1753
Query: 740 -KDEKLKTVEELLETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAKQNDQVSFASLV 796
++ + K + + + ++ K+E+ + E ++ + V+DL+ + ++ A +
Sbjct: 1754 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA--L 1811
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856
+ KK I + + +++ +E +E+E + A K L+ E ++ +
Sbjct: 1812 KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG---------------LRKHERRVKEL 1856
Query: 857 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916
EE K++ + LQ + +S K +E + + ++ ++F +L+ L+E E
Sbjct: 1857 TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS---NTNLAKFRKLQHELEEAE 1913
Query: 917 NELKRLEAMLKE 928
E+ + +
Sbjct: 1914 ERADIAESQVNK 1925
Score = 87.4 bits (215), Expect = 8e-17
Identities = 115/602 (19%), Positives = 264/602 (43%), Gaps = 45/602 (7%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEK 829
L K L+AK + A EE+ + K K LE E ++
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-------LEDECSELKKDID 961
Query: 830 TVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN-ESLKAHV 888
++L++ +KV++ ++ + K + + A L+E L K LQ+ ++ + L+A
Sbjct: 962 DLELTL-AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1020
Query: 889 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK 948
+V + Q ++LE L++++ LE ++ E DL + + D+++E
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE-- 1078
Query: 949 LFKSQI-EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN 1007
K Q+ E+LK++ ++ ++ E+ + + +K+I L ++ L++ +E +R
Sbjct: 1079 --KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 1008 DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1067
++ + L + L++ TS + + + E E +++ + L + L
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDL-----EEATLQ 1190
Query: 1068 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS---VLAETE 1124
+ KK + +A E++ L+ ++ ++ + +++E + S +++ +
Sbjct: 1191 HEATAATLRKKHADSVAEL--GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 1125 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE 1184
G L+K+ R++E + ++ K K +E + I + + + RL++E+ + E+E
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA-------QRGRLQTESGEFSRQLDEKE 1301
Query: 1185 HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1244
L +L + + + ++ ELK QL E E + +A L ++ +L++
Sbjct: 1302 ALVSQLSRG---KQAFTQQIEELKRQLEE-------EIKAKNALAHALQSSRHDCDLLRE 1351
Query: 1245 KIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
+ + ++ + TE ++ T Q +L++ + + Q+L +EH +
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 1304 VL 1305
+
Sbjct: 1412 AV 1413
Score = 35.4 bits (80), Expect = 0.36
Identities = 39/221 (17%), Positives = 93/221 (42%), Gaps = 11/221 (4%)
Query: 1091 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1147
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 841 KIKPLLKSAETEKEMATMKE-EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1205
+ + + + +L ++ K++ + E + EL +K ++E E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECS 954
Query: 1206 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1265
ELK +++ L + E+ + + + + I K + ++ +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 1266 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 159 bits (401), Expect = 2e-38
Identities = 266/1283 (20%), Positives = 530/1283 (41%), Gaps = 153/1283 (11%)
Query: 88 DALAVEDD-----QVAPVPLNVVET-SSSVRERKKKEKKQKPVLEEQVIKESDASK--IP 139
D L + +D Q APVP T + + K++ LE Q + S + +
Sbjct: 139 DGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLS 198
Query: 140 GKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQE 199
G P+ Q TP + KK+ ++S + + ++ K + + Q
Sbjct: 199 GSPASPMGDILQ-TPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQR 257
Query: 200 TKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQ 259
+ + +K+A+S + E L + D + + R + + LK Q
Sbjct: 258 IDRLALLNEKQAASPLEPKE----------------LEELRDKNESLTMR-LHETLKQCQ 300
Query: 260 VEGIQKSGTKKLKTETDKENAEVKFK--DFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
+KS + + +EN ++ FK +F L+ + + +E L +E S Q+
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE------LTEEHSKATQE 354
Query: 318 ALKKSSK--GELTTLIHQ---LQEKDKLL----AAVKEDAAATKDRCKQLTQEMMTEKER 368
L+K ++ EL+ + L+EK+++L + ++E + +D Q E++ +
Sbjct: 355 WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-- 412
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
+ + +K TL + Q ++ + E Q + K R E E L
Sbjct: 413 --LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITD 470
Query: 429 LRDAVSNTTN---QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQ 485
L+ ++SN + +LE A +L A L +ELT +QQ++ + +Q A +
Sbjct: 471 LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530
Query: 486 LKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
+ QL + ++ E+ +R H+ Q L S KE +++ + K T +Q
Sbjct: 531 KQAQLAQTLQQQEQASQGLR-----HQVEQ--LSSSLKQKEQQLKEVAEKQEAT---RQD 580
Query: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA--AQTSASVLAE 603
Q+L E + + + ++ Q+ + LE+ +A K +I Q Q+A A+ SA
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQL-EALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639
Query: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663
+ + AE +++++ + + + R + E + + L++E QK A E+
Sbjct: 640 QAQREKAELSRKVEELQACVETARQ---EQHEAQAQVAELELQLRSEQQK----ATEKER 692
Query: 664 AAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE 723
A E +++Q+ + + +++ + L+ E K L +Q + + + ++LV +
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEE---KRRAADALEEQQRCISELKAETRSLVEQ 749
Query: 724 --QPNKDVVEQ------MEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSL 775
+ K++ E+ +E +Q+ E + E+L L + + + +E L
Sbjct: 750 HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ---HTAESECEQL 806
Query: 776 TKEV----QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
KEV + + Q ++ + ++ +E + E+ K + +EL EA+ KVA E
Sbjct: 807 VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR--QELQEAK-EKVAGIESHS 863
Query: 832 QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 891
+L I+ + EL L N +A+ + +EK++ K DL E + A +EV
Sbjct: 864 ELQISRQQNELAEL------HANLARALQQVQEKEV-RAQKLADDLSTLQEKMAATSKEV 916
Query: 892 AQHN--LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQ-LLQDVQDENK 948
A+ +++A + E+V KE R L+E++ TQ LQ ++ E +
Sbjct: 917 ARLETLVRKAGEQQETASRELV-KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 949 LFKSQIEQLK-----QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1003
+++E+L+ Q QQ E+ ++ ER + + L E + + +
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 1004 KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVP 1063
N+ R + EALA + K + +K R +EA +++ E L++ ++
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLR--GLEAAQIKELEELRQTVKQLK-- 1091
Query: 1064 SNLSYGEWLHGFEKKAKECMAGTSG---------SEEVKVLEHKLKEADEMHTLLQLECE 1114
L+ E H A+ AG + EV LE + ++ E L+ E
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE 1151
Query: 1115 KYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK 1174
++ AE + L+ LQ +E E + + QS+ S+++EL R++ +
Sbjct: 1152 AERASRAERDSALETLQGQLE-----------EKAQELGHSQSALASAQRELAAFRTKVQ 1200
Query: 1175 D-----------IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN 1223
D + R+E E + E E S +V E + + E + E
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260
Query: 1224 ERQKVAGDLHKAQQSLELIQ----SKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ 1279
+ QK+ ++ L L+Q S +AA ++ + S E+ ++ S +L Q
Sbjct: 1261 KSQKL-------EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313
Query: 1280 TVTQLQQLLQAVNQQLTKEKEHY 1302
+T + + + Q+L +E +
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKF 1336
Score = 140 bits (352), Expect = 1e-32
Identities = 252/1264 (19%), Positives = 530/1264 (41%), Gaps = 133/1264 (10%)
Query: 86 LSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L+ + +D ++A + E + + + +++++ L QV + S + K ++++
Sbjct: 510 LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 146 VP----VTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKR--QEALPLHQE 199
V T+Q A A++++ + ++ + Q + +E Q+ L + E
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 200 TKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQ 259
+ + + +A +K + V+E + A + ++ V + E+ Q
Sbjct: 630 ARDSAQTSVTQAQREKAELSRK-VEE--LQACVETARQEQHEAQAQVAELEL-------Q 679
Query: 260 VEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS-EDEALCVVDLLKEKSGVIQDA 318
+ Q+ T+K + +K+ + + + SLK S E+E D L+E+ I +
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL-------TQEMMTEKERSNV 371
K E +L+ Q + + K L + + R +QL T+ + E +
Sbjct: 740 -----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431
+ L KE ++ + S QE Q FQ+ ++ E +QE ++
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
V+ + E + S + N+L + +A L L + +Q++EV+ + + L+ ++
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLARALQQ----VQEKEVRAQKLADDLSTLQEKMA 910
Query: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV-AKENEVQSLHSKLTDTLVSKQQLEQRL 550
+ +++ +RK + E A ++L + A + + + L + S Q
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA---- 966
Query: 551 MQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
+Q ME E +++ E E L+ + + Q + + Q ++ +++ + + L K
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK-- 1024
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
A + + + +++L +R + +E L E+ KL+ L +AA ELE
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL---EAAQIKELE 1081
Query: 670 KMQQSVYVKDDKIRLLEEQ------LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE 723
+++Q+V +++ E++ Q E + + E + +AL++EV KL+ +
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP---TGPKLEALRAEVSKLEQQCQK 1138
Query: 724 QPNKDVVEQMEKCIQ-------EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Q ++ + +E+ ++ E+D L+T++ LE ++ + L + + E ++
Sbjct: 1139 Q--QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKTVQL 833
+VQD +K D+ + + V ++ K+ I S+EE +L ++L+ + K ++
Sbjct: 1197 TKVQD-HSKAEDE--WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 834 SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK--AHVQEV 891
+ ++ ++ Q L EE++ ++A E + A + L+EE +SL+ A Q V
Sbjct: 1254 LVMAESEKSQKL----EERLRLLQA---ETASNSARAAERSSALREEVQSLREEAEKQRV 1306
Query: 892 AQHNLKE--ASSASQFEELEIVLK-------EKENELKRLEAMLKERE---SDLSSKTQL 939
A NL++ S A + EEL LK +KE L L+ + S+L L
Sbjct: 1307 ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL 1366
Query: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 999
Q +Q E + + + +Q+ Q A ELL+ ++E+ EL L+ V
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGL--RAELLRA----QRELG----ELIPLRQKV 1416
Query: 1000 EHQRKKNNDLREKNWEAMEALASTEKM--LQDKVNKTSKERQ---QQVEAVELE-AKEVL 1053
Q + LR + E L+ +K L + N+ ER +Q VEL+ A+E
Sbjct: 1417 AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY 1476
Query: 1054 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE--EVKVLEHKLKEADEMHTLLQL 1111
+ V + E + A+E T+ E +VKVLE + + +E
Sbjct: 1477 VQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER------ 1530
Query: 1112 ECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRS 1171
QKL VEQ E + + + + K++ S +S+ + ++L++
Sbjct: 1531 ----------------QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 1172 ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGD 1231
++E + L+ +L + + + S K Q+ + T ++ + Q +
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ----E 1630
Query: 1232 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1291
L + +SLE +Q + + + + + ++ E E L V L+ +
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA 1690
Query: 1292 NQQL 1295
+QQL
Sbjct: 1691 DQQL 1694
Score = 126 bits (317), Expect = 1e-28
Identities = 238/1093 (21%), Positives = 453/1093 (41%), Gaps = 148/1093 (13%)
Query: 50 TKTDKKKAEKKKNKKK-----EIQNGNLHESDSESVPRDFKL--SDALAVEDDQVAPVPL 102
T+ ++KAE + ++ E HE+ ++ + +L A E ++VA
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
+ E +++E K K LEE+ + +DA + + + + + K
Sbjct: 699 QLQEQLQALKESLKVTKGS---LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 163 KKPGQKKSKNGSD------DQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQ 216
+ ++ + G + + + ET ++ + EA+ + E K+ ++ ++
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 217 KTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETD 276
+ E+ +E A LM + R+ + K ++V GI+ ++ + +
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLKEECEKA--RQELQEAK-EKVAGIESHSELQISRQQN 872
Query: 277 KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQL 334
E AE+ + +L+ + E A + D L +Q+ + +SK L TL+ +
Sbjct: 873 -ELAELH-ANLARALQQVQEKEVRAQKLADDLS----TLQEKMAATSKEVARLETLVRKA 926
Query: 335 QEKDKLLAA--VKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN 392
E+ + + VKE A A DR + +E + S + + +E+E N
Sbjct: 927 GEQQETASRELVKEPARAG-DRQPEWLEEQQGRQFCST------QAALQAMEREAEQMGN 979
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS---NTTNQLESKQSAELN 449
++ + Q + Q+ R Q E E+A L QE G + ++ +LE + LN
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 450 KLRQDYARL----VNELTEKTGKLQQ-------EEVQKKNAE---QAATQLKVQLQEAER 495
+ R ++A L + LTEK GK Q+ E Q K E Q QLK QL + E+
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 496 RWEE---VQSYIRKRTA----------------EHEAAQQDLQSKFVAKENEVQSLHSKL 536
QS RT E + +Q Q+ + + E +
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 537 TDTLVS--KQQLEQRLMQLMESEQKRVNKEESL---QMQVQDILEQNEALKAQIQQFHSQ 591
D+ + + QLE++ +L S+ + + L + +VQD + + KAQ+ + +
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 592 IAAQTSA-SVLAEE---LHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
+ S S L EE L++ + EK+ + K+ + + +E ++ EE L+ LL
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR-------LL 1272
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+AE A A E+++A L + QS+ + +K R+ E L+ E++++ E + L +
Sbjct: 1273 QAETASNSARAAERSSA---LREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL 1329
Query: 708 KA--------------LKSEVQKLQTLVSEQ-PNKDVVEQM-------EKCIQEKDEKLK 745
KA L+ E Q LVSE P K + +Q+ EK +E+ E+ K
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Query: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
L L++ + EL +R + + + Q L+A++ S++++ ++ E
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE 1449
Query: 806 KDGKIKSVEEL----LEAELLKVANKE----KTVQLSITSKVQELQNLLKGKEEQMNTMK 857
++ + L LE EL + K V+ +++ E+Q + ++ M
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMT 1509
Query: 858 AVLE-EKEKDLANTGKWLQDLQEENESLKAHVQEVA-------------QHNLKEASSAS 903
A E K K L Q QEE + L A V+++ L ++ AS
Sbjct: 1510 AKYEGAKVKVLEER----QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565
Query: 904 QFEELEIVLK-----EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958
+ ++ ++ E + E +RL+A L E ++ LS K Q + + + + K+ + K
Sbjct: 1566 KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625
Query: 959 QQNYQQASSFPPHEELLKVISEREKEISGLWNELD--SLKDAVEHQRKKNNDLREKNWEA 1016
QQN + E+L K E E L +EL LK Q ++ + ++ EA
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 1017 MEALASTEKMLQD 1029
+A ++ L+D
Sbjct: 1686 Q--VAHADQQLRD 1696
Score = 102 bits (253), Expect = 3e-21
Identities = 154/732 (21%), Positives = 309/732 (42%), Gaps = 95/732 (12%)
Query: 304 VVDLLKEKSGVIQD-ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAAT-------KD-- 353
V L +E+ D AL+K+++ EL + + ++ A ++A A KD
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 354 --RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQV 411
+ + L + E E + ++K+++ EKEH + T+ K + +
Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKL-- 469
R AE++ L+Q+ ++ + LE+++++ + L +L EK +L
Sbjct: 1126 R----AEVSKLEQQCQKQQEQADSLERSLEAERASRAER-DSALETLQGQLEEKAQELGH 1180
Query: 470 QQEEVQKKNAEQAATQLKVQ----------------LQEAERR------WEEVQSYIRKR 507
Q + E AA + KVQ QEAER+ EE S + ++
Sbjct: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ 1240
Query: 508 TAEHEAAQQDLQSKFVAKENEVQSLHSKL----TDTLVSKQQLEQRLMQLME-------- 555
E E ++L+ +A+ + Q L +L +T + + +R L E
Sbjct: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREE 1300
Query: 556 SEQKRV---NKEESLQMQVQDILEQNEALKAQIQQFHSQIAA-------QTSASVLAEEL 605
+E++RV N + L Q + E + LKA ++F + A TS L EL
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
Query: 606 ------------HKVIAEKD--KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEV 651
+ AEK ++++Q++ + R L + EL ++ + + +
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
+ Q L E+A+ A +L ++++ + ++ R L E+ + + E ++ ++A +
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN--LGRQFLEVEL----DQARE 1474
Query: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
VQ+L + ++ + + ++++ Q +L+ + E ++V EE + E
Sbjct: 1475 KYVQELAAVRADAETR--LAEVQREAQSTARELEVMTAKYEGAKVKVL---EERQRFQEE 1529
Query: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV 831
LT +V+ L+ Q +Q VEEL K + + D K ++ L+A + ++
Sbjct: 1530 RQKLTAQVEQLEVFQREQTK---QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586
Query: 832 QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 891
Q + +++ ELQ L KE+ K +E+ + + Q+LQE+ SL+ +E
Sbjct: 1587 Q-RLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKEN 1645
Query: 892 AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV---QDENK 948
+ + + ++ + KE E + L A ++ E+ ++ Q L+D+ Q
Sbjct: 1646 KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATD 1705
Query: 949 LFKSQIEQLKQQ 960
KS+ Q K Q
Sbjct: 1706 ALKSREPQAKPQ 1717
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 158 bits (400), Expect = 3e-38
Identities = 214/1079 (19%), Positives = 465/1079 (43%), Gaps = 145/1079 (13%)
Query: 317 DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ-------------EMM 363
+A +K + ++ TL+ + + + A + A ++RC QL + E
Sbjct: 871 EAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERA 930
Query: 364 TEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---E 416
++E N +T +++D L+K+ + + + +E + K + + E+M +
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 417 AEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
IA L +E L++A T + L++++ ++N L + +L ++ + G L+QE+
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEK--- 1046
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
++++ L+ A+R+ E ++ T + E +Q L K KE E+ L SK+
Sbjct: 1047 --------KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098
Query: 537 TDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
D QL++++ +L E E +R ++ ++ + Q D+ + E + ++++
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSDLSRELEEISERLEEA 1157
Query: 589 HSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DRLTSKEEELKDIQNM 643
+AQ + E E K+ + ++ Q E + A+ R D + E++ ++Q +
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217
Query: 644 NFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNK 696
L K E+ L + + A LEKM +++ + +I+ EE+ Q I++
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ L ++ ++ + TLVS+ Q +E++++ ++E+ + + L
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337
Query: 752 ETG------LIQVATKEEELNA-IRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVI 803
++ L + +E+E A ++ S EV + K + D + +EE KK +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQ--------------------LSITSKVQELQ 843
+ +++ EE +EA K A+ EKT Q ++ K +
Sbjct: 1398 AQ---RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 844 NLLKGKEEQMNTMKAVLEEKEKDLANTG--------------KWLQDLQEENESLKAHVQ 889
+L +++ A LE +K+ + L+ L+ EN++L+ Q
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ---Q 1511
Query: 890 EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 949
E++ + A + ELE + K+ E E L+A L+E E+ L + + +Q E
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 950 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1009
KS++++ + ++ + ++++ + + E+ S DA+ ++K DL
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNH--IRIVESMQSTLDA---EIRSRNDAIRLKKKMEGDL 1626
Query: 1010 REKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE-LEAKEVLKKLFPKVSVPSNLSY 1068
E + A + L++ N + + Q+ + L ++E LK+ V +NL
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1069 GEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ 1128
E ++ + + T S K+ E +L +A E LL + + L T+ +
Sbjct: 1687 AE-----IEELRATLEQTERSR--KIAEQELLDASERVQLLHTQ----NTSLINTK---K 1732
Query: 1129 KLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEM 1188
KL+ + Q + + + + E+ ++ + + T + E L+ E +L R +++LE
Sbjct: 1733 KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1792
Query: 1189 ELEKAEMERSTYVTEVRELKAQLNET-LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIV 1247
V++L+ +L+E L+ + + QK+ + + + +E Q + V
Sbjct: 1793 --------------TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNV 1838
Query: 1248 KAAGDTTVIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQV 1304
+A E +++ +TE K + L V +LQ +++ +Q + +E V
Sbjct: 1839 EAVKGLRKHERKVKELTYQTEEDRKNIL--RLQDLVDKLQAKVKSYKRQAEEAEEQSNV 1895
Score = 143 bits (361), Expect = 9e-34
Identities = 221/1154 (19%), Positives = 495/1154 (42%), Gaps = 164/1154 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E +++ K +K+++ E V L+ + L
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVT--LMQEKNDLQLQVQ 896
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A++ + D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 897 AEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 955
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A +
Sbjct: 956 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E + + K+ +
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
Q+ M + ++Q++ ++ + E L+ + + E +L K ++ +
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIED-----EQALGMQLQKKIKELQARI 1119
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
EL E+ ++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1120 EELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++M++
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 573 DILEQNEAL---KAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIK--QTEDSLAS- 625
D+ E + K +++ + Q S EE ++I + Q QTE S
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 626 ---ERDRLTS-----KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E+D L S K+ + I+ + L+ E++ ALA+ ++ H+ +
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD-------- 1345
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
LL EQ + E K E + ++ N + K +T ++ E++E+
Sbjct: 1346 ------LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR-----TEELEEAK 1394
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFA 793
++ ++L+ EE +E + A+ E+ ++ E L +V+ A Q +F
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 794 SLVEELKKVIHEKDGKIKSVEE---LLEAELLKVAN--------------KEKTVQLSIT 836
++ E K+ E ++++ ++ L EL K+ N + K +Q I+
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1514
Query: 837 S----------KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 886
++ EL+ + K E++ + ++A LEE E L + + +Q E +K+
Sbjct: 1515 DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 887 HVQ-----------EVAQHNLKEASSASQFEELEIVLKEKENELKR-LEAMLKERESDLS 934
V ++ +++++ S + EI + LK+ +E L E E L+
Sbjct: 1575 EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLN 1634
Query: 935 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 994
++ + + +++ LK + E+L + ++ E+ + L E++
Sbjct: 1635 HANRMAAEAL---RNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEE 1691
Query: 995 LKDAVEHQRKKNNDLREKNWEAME----------ALASTEKMLQDKVNKTSKERQQQVEA 1044
L+ +E + ++ +A E +L +T+K L+ +++ E + ++
Sbjct: 1692 LRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQE 1751
Query: 1045 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1104
++ K + + L + ++ K+ + T VK L+H+L EA++
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT-----VKDLQHRLDEAEQ 1806
Query: 1105 MHTLL-QLECEKYKSVLAETEGILQKLQ-RSVEQ----EENKWKVK-----VDESHKTIK 1153
+ + + +K ++ + E EG ++ Q R+VE +++ KVK +E K I
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Query: 1154 QMQSSFTSSEQELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRELK 1208
++Q + +++ + + ++ E NL + R ++ ELE+AE ++V +L+
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRR-IQHELEEAEERADIAESQVNKLR 1925
Query: 1209 AQLNETLTKLRTEQ 1222
+ E TK+ +E+
Sbjct: 1926 VKSREVHTKIISEE 1939
Score = 124 bits (312), Expect = 5e-28
Identities = 177/859 (20%), Positives = 371/859 (43%), Gaps = 89/859 (10%)
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
+++ +++ ++ Q V+ + W ++ Y + + A + + + +
Sbjct: 802 RVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSA---ETEKEMANMKE 858
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ---DILEQNEALKAQ 584
E + +L T +++LE++++ LM+ ++ LQ+QVQ D L E Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQ-------EKNDLQLQVQAEADSLADAEERCDQ 911
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDIQNM 643
+ + Q+ A+ K + E+ + ++ L +++ +L + EL KDI ++
Sbjct: 912 LIKTKIQLEAKI----------KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKIL 703
L ++ A N+ E+ + +++ + + L+E Q + + E +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 704 NDQNKA-LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
N KA +K E Q S + K + +E+ ++ + LK +E +
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
E+L E S L +++D +A L +L+K I E +I+ +EE +EAE
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQA----------LGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 823 KVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQE--- 879
A EK Q S S+ EL+ + + EE A +E +K A K +DL+E
Sbjct: 1132 SRAKAEK--QRSDLSR--ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 880 ENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL 939
++E+ A +++ +H A Q + L+ V ++ E E ++ + + S++ + ++
Sbjct: 1188 QHEATAATLRK--KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKA 1245
Query: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 999
+++ + + Q+ ++K + +Q + E S +E D+L +
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 1000 EHQR----KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1055
+ ++ +L+ + E ++A ++ LQ + R+Q E E EAK L++
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE--EQEAKAELQR 1363
Query: 1056 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHKLKEADEMHTLLQLEC- 1113
K +N +W +E A + T EE K L +L++A+E + +C
Sbjct: 1364 AMSK----ANSEVAQWRTKYETDA---IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCA 1416
Query: 1114 --EKYKSVLA-ETEGI-------------LQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1157
EK K L E E + L K QR+ ++ +WK K +E+H ++ Q
Sbjct: 1417 SLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1476
Query: 1158 SFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNE 1213
S EL ++++ ++ +E L+RE ++L+ E+ S ++ E +++E
Sbjct: 1477 ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEI-------SDLTEQIAEGGKRIHE 1529
Query: 1214 TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM 1273
+ + E+ ++ L +A+ SLE + KI++ + ++ S+V + ++E
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEID 1588
Query: 1274 SVSLN--QTVTQLQQLLQA 1290
+ N + V +Q L A
Sbjct: 1589 QMKRNHIRIVESMQSTLDA 1607
Score = 55.1 bits (131), Expect = 4e-07
Identities = 114/639 (17%), Positives = 268/639 (41%), Gaps = 77/639 (12%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTD----KKKAEKKKNKKKEIQNGNLHES--------- 75
+K L +E+ AK L ++ D +++ E+++ K E+Q +
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 76 -DSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI---- 130
+++++ R +L +A ++ +V ++ +K +++ + +E+ +I
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 131 ----------KESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
K+ + KI + + T S+ + K KN ++ +
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
+ETL +K + + T+Q + GK+ +K K + V ++ + A ++ A
Sbjct: 1499 LETLKRENKNLQQ-EISDLTEQIAEGGKRIHELEKIKKQ-VEQEKSELQAA-----LEEA 1551
Query: 241 DSSPVVDKREVIDL-LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSED 299
++S ++ +++ + L+ +QV KS + E D+E ++K ++ + +++M + D
Sbjct: 1552 EASLEHEEGKILRIQLELNQV----KSEVDRKIAEKDEEIDQMK-RNHIRIVESMQSTLD 1606
Query: 300 EALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLT 359
+ + ++ I+ LKK +G+L + QL +++ A + T+ K T
Sbjct: 1607 AEI------RSRNDAIR--LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKD-T 1657
Query: 360 QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI 419
Q + + RS +K+++ +E+ N+ Q +I + T + + +++ EQ +
Sbjct: 1658 QLHLDDALRSQ---EDLKEQLAMVERRANLLQAEIE-ELRATLEQTERSRKIAEQELLDA 1713
Query: 420 AHLKQENGILRDAVSNTTNQLE---SKQSAELNKLRQ--------------DYARLVNEL 462
+ Q ++ NT +LE S+ E+ + Q D A + EL
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRW-----EEVQSYIRKRTAEHEAAQQD 517
++ E KKN EQ L+ +L EAE+ +++Q + R E E +
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-LEARVRELEGEVES 1832
Query: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ 577
Q + V ++ K+ + ++ + +++L + K K +S + Q ++ EQ
Sbjct: 1833 EQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 578 NEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
+ ++ ++ ++ + +AE + K +++
Sbjct: 1893 SNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 38.5 bits (88), Expect = 0.043
Identities = 39/214 (18%), Positives = 90/214 (42%), Gaps = 10/214 (4%)
Query: 1098 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDESHKTIKQ 1154
K E ++ ++ E EK K LA+TE ++L+ ++ QE+N +++V ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 1155 MQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVRELKAQLN 1212
+ + +L ++ K++ + E + EL +K ++E E ELK ++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-----DECSELKKDID 959
Query: 1213 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1272
+ L + E+ + + + + I K + ++ + + +E
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1019
Query: 1273 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+L + +L+Q + + L +EK+ LE
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 157 bits (398), Expect = 5e-38
Identities = 217/1096 (19%), Positives = 469/1096 (42%), Gaps = 163/1096 (14%)
Query: 308 LKEKSGVIQDALKKSS--KGELTT-LIHQLQEKDKLLAAVKEDA---AATKDRCKQLTQ- 360
+KE+ +D L KS + EL ++ L+EK+ L V+ +A A ++RC+QL +
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E E+E N +T +++D L+K+ + + + +E
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++ T + L++++ ++N L + +L +
Sbjct: 975 ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED-KVNILTKAKTKLEQQ 1033
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ T + E +Q L K
Sbjct: 1034 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D + QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKA-EKQRSD 1141
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSAS--------VLAEELHKVIAEKDKQI----KQTED 621
+ + E + ++++ +AQ + L +L + + + + K+ D
Sbjct: 1142 LSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD 1201
Query: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
S+A +++ + + + ++ LK E L + A + A LEKM +S+ + +
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKC 736
++ EE+ Q I++ + L + ++ + LVS+ Q + +E+++
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321
Query: 737 IQEKDEKLKTVEELLETG-----LIQVATKEEELNAIRTEN--SSLTKEVQDLKAK-QND 788
++E+ + + L++ L++ +EE+ + S EV + K + D
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1381
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQ---------------- 832
+ +EE KK + + +++ EE +EA K A+ EKT Q
Sbjct: 1382 AIQRTEELEEAKKKLAQ---RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 833 ----LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG--------------KWL 874
++ K + +L +++ +A LE +K+ + L
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 875 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 934
+ L+ EN++L+ QE++ + A Q ELE + K+ E E ++A L+E E+ L
Sbjct: 1499 ETLRRENKNLQ---QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 935 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 994
+ + +Q E KS++++ + ++ + +V+ + + E+ S
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--TRVVETMQSTLDA---EIRS 1610
Query: 995 LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE-LEAKEVL 1053
DA+ ++K DL E + A + L++ N ++ Q+ + L +E L
Sbjct: 1611 RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDL 1670
Query: 1054 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHKLKEADEMHTLLQLE 1112
K+ V +NL + + +E A +E K+ E +L +A E LL +
Sbjct: 1671 KEQLAIVERRANL--------LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ 1722
Query: 1113 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1172
+ L T+ +KL+ V Q +++ + + ES ++ + + T + E L+ E
Sbjct: 1723 ----NTSLINTK---KKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE 1775
Query: 1173 NKDIENLRREREHLEMEL--------EKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1224
+L R +++LE + E ++ ++++L+A++ E ++ EQ
Sbjct: 1776 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKR 1835
Query: 1225 RQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQL 1284
+ L K ++ ++ +++ +TE K + L V +L
Sbjct: 1836 NAEAVKGLRKHERRVK-------------------ELTYQTEEDRKNVL--RLQDLVDKL 1874
Query: 1285 QQLLQAVNQQLTKEKE 1300
Q +++ +Q + +E
Sbjct: 1875 QAKVKSYKRQAEEAEE 1890
Score = 155 bits (392), Expect = 2e-37
Identities = 219/1155 (18%), Positives = 496/1155 (42%), Gaps = 168/1155 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q++ K+ +K+++ E V L+ + L
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVT--LLKEKNDLQLQVQ 895
Query: 240 ADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKE-NAEV-----KFKDFLLSLKT 293
+++ + D E + L ++++ K + E ++E NAE+ K +D LK
Sbjct: 896 SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKD 353
+ +D L + + KEK +++ ++ L ++ D+ +A + ++ A ++
Sbjct: 956 DI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDETIAKLSKEKKALQE 1004
Query: 354 RCKQLTQEMMTEKERSNVVI---TRMKDRI----GTLEKEHNV------FQNKIHVSYQE 400
+Q ++ E+++ N++ T+++ ++ G+LE+E + + K+ +
Sbjct: 1005 THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1064
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Q+ M + ++Q++ ++ + E +SN +++E +Q+ E+ +L++ L
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFE-------ISNLISKIEDEQAVEI-QLQKKIKELQA 1116
Query: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHEA 513
+ E +++ E + AE+ + L +L+E R EE +KR AE +
Sbjct: 1117 RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
++DL+ + E V +L K D++ +L +++ L +QK ++ L+M+ D
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMA---ELGEQIDNLQRVKQKLEKEKSELKMETDD 1233
Query: 574 ILEQNEAL---KAQIQQFHSQIAAQTSASVLAEE---------------LHKVIAEKDKQ 615
+ EA+ K +++ + Q S EE L E +Q
Sbjct: 1234 LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQ 1293
Query: 616 IKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675
+ + +D+L S+ R SK+ + I+ + L+ E + ALA+ ++ H+ +
Sbjct: 1294 LDE-KDALVSQLSR--SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCD------ 1344
Query: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
LL EQ + E K E + L+ N + K +T ++ E++E+
Sbjct: 1345 --------LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR-----TEELEE 1391
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVS 791
++ ++L+ EE +E + A+ E+ ++ E L +V+ A Q +
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 792 FASLVEELKKVIHEKDGKIKSVEE---LLEAELLKVAN--------------KEKTVQLS 834
F ++ E K+ E ++++ ++ L EL KV N + K +Q
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQE 1511
Query: 835 ITS----------KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 884
I+ ++ EL+ + K E++ ++A LEE E L + + +Q E +
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 885 KAHV--------QEVAQHNLKEASSASQFEE-LEIVLKEKENEL---KRLEAMLKERESD 932
K+ V +E+ Q + L+ ++ + + L K++E L E E
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQ 1631
Query: 933 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 992
L+ +L + + +++ LK+ + E+L + ++ E+ + L E+
Sbjct: 1632 LNHANRL---AAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI 1688
Query: 993 DSLKDAVEHQRKKNNDLREKNWEAME----------ALASTEKMLQDKVNKTSKERQQQV 1042
+ L +E + ++ +A E +L +T+K L++ V++ E ++ +
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Query: 1043 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA 1102
+ ++ K + + L + ++ K+ + T VK L+H+L EA
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT-----VKDLQHRLDEA 1803
Query: 1103 DEMHTLL-QLECEKYKSVLAETEGILQKLQ----------RSVEQEENKWKVKVDESHKT 1151
+++ + + +K ++ + E EG ++ Q R E+ + + +E K
Sbjct: 1804 EQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1863
Query: 1152 IKQMQSSFTSSEQELERLRSENKDIE-----NLRREREHLEMELEKAEMERSTYVTEVRE 1206
+ ++Q + +++ + + ++ E NL + R+ L+ ELE+AE ++V +
Sbjct: 1864 VLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK-LQHELEEAEERADIAESQVNK 1922
Query: 1207 LKAQLNETLTKLRTE 1221
L+ + E TK+ E
Sbjct: 1923 LRVKSREVHTKISAE 1937
Score = 108 bits (270), Expect = 3e-23
Identities = 206/963 (21%), Positives = 405/963 (42%), Gaps = 189/963 (19%)
Query: 35 DEVLAKQKRE-QKLIPTKTDKKKAEKKKNKK-KEIQN-----GNLHESDSESVPRDFKLS 87
DE L K++ E LI D++ E + KK KE+Q G E++ S + K
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQR 1139
Query: 88 DALAVEDDQVAP-VPLNVVETSSSVRERKKKE---KKQKPVLEEQVI-----------KE 132
L+ E ++++ + TS+ V KK+E +K + LEE + K
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH 1199
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEA--------------AASKKKPGQKKSKNGSDDQD 178
+D+ G++++ + KQ ++ A SK K +K +DQ
Sbjct: 1200 ADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQV 1259
Query: 179 KKVETLMVPSKR-------------QEALPLHQETKQESGSGKKKASSKKQKTENVFVDE 225
+++T +R EA ++ ++ + + SK+ T+ + E
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQI---E 1316
Query: 226 PLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFK 285
L H NA + + R DLL+ E ++ G +L+ K N+EV
Sbjct: 1317 ELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE--EQEGKAELQRALSKANSEVA-- 1372
Query: 286 DFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVK 345
+ E +A+ +++ +++A KK L +LQE ++ + AV
Sbjct: 1373 ------QWRTKYETDAI-------QRTEELEEAKKK--------LAQRLQEAEEHVEAVN 1411
Query: 346 EDAAA---TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ 402
A+ TK R + +++M + ERSN + + +K + ++ K Y+ETQ
Sbjct: 1412 AKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK----YEETQ 1467
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Q+ + E+ +K + + +QLE+ + N L+Q+ + L ++
Sbjct: 1468 AELEASQKESRSLSTELFKVK-------NVYEESLDQLETLRRENKN-LQQEISDLTEQI 1519
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
E ++ + E KK EQ +++ L+EAE E + I + E + ++ K
Sbjct: 1520 AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1579
Query: 523 VAKENEVQSL---HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
K+ E+ L H+++ +T+ S E R ++ RV K+ + +I + N
Sbjct: 1580 AEKDEEIDQLKRNHTRVVETMQSTLDAEIR----SRNDALRVKKKMEGDLNEMEI-QLNH 1634
Query: 580 ALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
A + + + + + +L E +LH +D+L + D +E+L
Sbjct: 1635 ANRLAAESLRNY---RNTQGILKETQLH------------LDDALRGQEDL----KEQLA 1675
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
++ LL+AE+++L A LE+ ++S R + EQ E+ + E
Sbjct: 1676 IVERRANLLQAEIEELWAT----------LEQTERS--------RKIAEQ---ELLDASE 1714
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
++L+ QN +L + +KL+ VS+ + ++E+ IQE + EE + +
Sbjct: 1715 RVQLLHTQNTSLINTKKKLENDVSQ-----LQSEVEEVIQES----RNAEEKAKKAITDA 1765
Query: 759 ATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELL- 817
A EEL K+ QD A +E +KK + + +K ++ L
Sbjct: 1766 AMMAEEL-----------KKEQDTSAH----------LERMKKNLEQT---VKDLQHRLD 1801
Query: 818 EAELLKVANKEKTVQLSITSKVQELQN-----------LLKGKEEQMNTMKAVLEEKEKD 866
EAE L + +K +Q + ++V+EL+ +KG + +K + + E+D
Sbjct: 1802 EAEQLALKGGKKQIQ-KLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEED 1860
Query: 867 LANTGKWLQDLQEENES-LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM 925
N + LQDL ++ ++ +K++ ++ + + ++ S+F +L+ L+E E E+
Sbjct: 1861 RKNVLR-LQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQ 1919
Query: 926 LKE 928
+ +
Sbjct: 1920 VNK 1922
Score = 90.9 bits (224), Expect = 7e-18
Identities = 120/615 (19%), Positives = 272/615 (44%), Gaps = 71/615 (11%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV ++ + L
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 823 KVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT-GKWLQDLQEEN 881
KV ++ + +KV+ L + G +E + A L +++K L T + L DLQ E
Sbjct: 966 KVEKEKHATE----NKVKNLTEEMAGLDETI----AKLSKEKKALQETHQQTLDDLQAEE 1017
Query: 882 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 941
+ K ++ A+ L++ Q ++LE L++++ LE ++ E DL +
Sbjct: 1018 D--KVNILTKAKTKLEQ-----QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 942 DVQDENKLFKSQI-EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1000
D++++ K Q+ E+L+++ ++ ++ E+ V + +K+I L ++ L + +E
Sbjct: 1071 DMEND----KQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 1001 HQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS------KERQQQVEAVELEAKEVLK 1054
+R ++ + L + L++ TS K+R+ + + + + +E
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE--- 1183
Query: 1055 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECE 1114
+ L + + KK + MA E++ L+ ++ ++ + L++E +
Sbjct: 1184 ---------ATLQHEAMVAALRKKHADSMAEL--GEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 1115 KYKS---VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRS 1171
S +++ +G L+K+ RS+E + ++ K K +E + I + + + RL++
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTA-------QRARLQT 1285
Query: 1172 ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGD 1231
E + E++ L +L ++ + ++ ELK QL E E + +A
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRS---KQASTQQIEELKHQLEE-------ETKAKNALAHA 1335
Query: 1232 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET-MSVSLNQTVTQLQQLLQA 1290
L ++ +L++ + + ++ + +E ++ T Q +L++ +
Sbjct: 1336 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1395
Query: 1291 VNQQLTKEKEHYQVL 1305
+ Q+L + +EH + +
Sbjct: 1396 LAQRLQEAEEHVEAV 1410
Score = 69.7 bits (169), Expect = 2e-11
Identities = 144/740 (19%), Positives = 289/740 (39%), Gaps = 88/740 (11%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVR 112
K+K EK+K++ K ++ +L S++E++ + L +DQV+ + E +
Sbjct: 1217 KQKLEKEKSELK-METDDL-SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN 1274
Query: 113 E-------------RKKKEKKQKPVLEEQVIKESDAS--KIPGKKVEPVPVTKQPTPPSE 157
+ ++ +K L Q+ + AS +I K + TK +
Sbjct: 1275 DLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAH 1334
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQ--------ETKQESGSGKK 209
A S + + ++Q+ K E SK + + + +E KK
Sbjct: 1335 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1394
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
K + + Q+ E H + + + + EV DL+ + +
Sbjct: 1395 KLAQRLQEAEE--------HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL---------K 320
K + DK +E K K + ++ +L K K+ V +++L
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN-VYEESLDQLETLRREN 1505
Query: 321 KSSKGELTTLIHQLQEKDKL---LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
K+ + E++ L Q+ E K L +K+ K + +E E I R++
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI-AHLKQENGILR--DAVS 434
+ ++ E KI +E Q++ +V E M++ + A ++ N LR +
Sbjct: 1566 LELNQVKSE---VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAE 494
N++E +LN + A + G L++ ++ +A + LK QL E
Sbjct: 1623 GDLNEME----IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVE 1678
Query: 495 RRWEEVQSYIRKRTA---EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
RR +Q+ I + A + E +++ + + + VQ LH++ T + +K++LE +
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738
Query: 552 QLM----ESEQKRVNKEESLQMQVQDILEQNEALK------AQIQQFHSQIAAQTSASVL 601
QL E Q+ N EE + + D E LK A +++ + QT +
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE-QTVKDLQ 1797
Query: 602 -----AEEL-----HKVIAEKDKQIKQTEDSLASERDR-------LTSKEEELKDIQNMN 644
AE+L K I + + ++++ E + +E+ R L E +K++
Sbjct: 1798 HRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQT 1857
Query: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
+ V +LQ L ++ A ++ + + + +LQHE+ E I
Sbjct: 1858 EEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAE 1917
Query: 705 DQNKALKSEVQKLQTLVSEQ 724
Q L+ + +++ T +S +
Sbjct: 1918 SQVNKLRVKSREVHTKISAE 1937
Score = 38.9 bits (89), Expect = 0.033
Identities = 41/221 (18%), Positives = 94/221 (42%), Gaps = 11/221 (4%)
Query: 1091 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE---QEENKWKVKVDE 1147
++K L + EM T+ + E +K K LA++E ++L+ + +E+N +++V
Sbjct: 838 KIKPLLKSAETEKEMATMKE-EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS 896
Query: 1148 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMEL--EKAEMERSTYVTEVR 1205
++ + + +L ++ K++ E E + EL +K ++E E
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE-----DECS 951
Query: 1206 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1265
ELK +++ L + E+ + + + + I K + + ++ +
Sbjct: 952 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLD 1011
Query: 1266 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+ +E L + T+L+Q + + L +EK+ LE
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLE 1052
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 152 bits (384), Expect = 2e-36
Identities = 235/1130 (20%), Positives = 489/1130 (43%), Gaps = 188/1130 (16%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVI--------------QD 317
T+ +E+ E K+ L LK ++ DE + +++L +E+ G+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 318 ALKKS------------SKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
+K++ +K ++ L +L+EK + L K++ + K+L QE M
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 366 KERSNVVITRM-KDRIGTL-EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
S+ RM +D + L EK V + + VS + + ++F + R + LK
Sbjct: 299 L--SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR------VEELK 350
Query: 424 QENGILRDAVSNTTNQLESKQ--SAELNKLRQDYARLVN-----ELTEKTGKLQQEEVQK 476
++N +L + + +QLE + S +L++L ++ +L E+ + + EE+ +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAE-HEAAQQDL--------QSKFVAKEN 527
+N Q + + WE Q RT+E EA Q+ L S+ + E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQI---SRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL------ 581
E QSL + + + +E ++++ E++ + +++ +I+++ ++L
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 582 -------KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
KAQ+++ + + + K++ ++++ + QT SL +R ++ S E
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQI------KILEQENEHLNQTVSSLR-QRSQI-SAE 579
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EI 693
+KDI+ N +L +++ + ++ +++K + K ++ LE +L H E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
N++ + KI N LK +K++ L EQ N + ++ ++ KLK + +
Sbjct: 640 ENELLQKKITN-----LKITCEKIEAL--EQENSE--------LERENRKLKKTLDSFKN 684
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Q+ + E+E + + EN L + V+ LK + A L E K++ EK+ ++K
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCAS---MKMAQLQLENKELESEKE-QLKKG 740
Query: 814 EELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 873
ELL+A K E + Q + + Q LQ L+ +++ +++ L++ E +
Sbjct: 741 LELLKASFKKTERLEVSYQ-GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN------ 793
Query: 874 LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL 933
Q LQ+ E LK + + Q + S + +LE K+ E E KRL + +++ L
Sbjct: 794 -QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 934 SSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 993
+ +++ ENK +I K+ + ++EL+K + K + L +L
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 994 SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVL 1053
S K + NNDL + E + + E++L D+ T R + +E+ + + L
Sbjct: 913 SEKLKTQQM---NNDLEKLTHELEKIGLNKERLLHDE-QSTDDSRYKLLES---KLESTL 965
Query: 1054 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
KK + KE E++ LE +L+E+ + L+ E
Sbjct: 966 KKSL--------------------EIKE--------EKIAALEARLEESTNYNQQLRQEL 997
Query: 1114 EKYKS---VLAETEGILQKLQRS--VEQEENKWKVKVDESHKTIKQMQSSFTSSEQ---- 1164
+ K L + + + +Q S + E+NKW+ + E+ + + +++ E+
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 1165 ---ELERLRSENKDIE------------------NLRREREHLEMELEKAEMERSTYVTE 1203
E + L+++ K +E +L+ + L+ + K ++E ST ++
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 1204 VRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP 1263
L Q + L + + +NE + V K ++ L+ + ++K E ++
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVI----KEREDLKSLYDSLIKDH------EKLELLH 1167
Query: 1264 ETESSEKETMSVSLNQTVTQLQQLLQAVNQ-------QLTKEKEHYQVLE 1306
E ++SE E++ +S + T+ + L+ ++ QL K+K + LE
Sbjct: 1168 ERQASEYESL-ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1216
Score = 128 bits (322), Expect = 3e-29
Identities = 238/1134 (20%), Positives = 496/1134 (43%), Gaps = 148/1134 (13%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHE-SDSESVPRDFKLSDALAVEDDQVA 98
+Q+ E+K K++ E+ + + K +Q N++ SD+ S DAL + +V
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVD 323
Query: 99 PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEA 158
+ V S +ER + K +EE +KE + + K + + +
Sbjct: 324 KLESEV----SRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 159 AASKKKPGQKKSKNGSDDQD-----KKVETLM-------VPSKRQEALPLHQETKQESGS 206
+K+ Q K+K + + KK+E LM + K+ LH + E S
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
Query: 207 GKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKS 266
+ S QK+ V+E + + + + + V + R +D VEG +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD-----SVEG---N 489
Query: 267 GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV---VDLLKEKSGVIQ--DALKK 321
+K LK E KEN + K +L + + + C DL+KEK+ + + + L++
Sbjct: 490 ASKILKME--KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRM---- 376
+S+ ++ L + + ++ ++++++ + + + R K + +E E +++
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 377 -KDRIGTLEKEH--------NVFQNKIHVSYQETQQMQMKFQQVR------EQMEAEIAH 421
+ R E EH +N++H +E + +Q K ++ E +E E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 422 LKQENGILR---DAVSNTTNQLES--KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
L++EN L+ D+ N T QLES K++++L++ + R V L + K+ Q +++
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 477 KNAEQAATQLKVQLQ------------EAERRWEEVQSYIRKRTAEHEAAQ-QDLQSKFV 523
K E QLK L+ E + ++++ ++T E+ + Q L+S+
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 524 AKENEVQSLHSKLTDTLVSKQQLEQ---------RLMQLMESEQKRVNKEESLQMQVQDI 574
E E Q+L L + +S ++LEQ + +E ++K++ KE Q +I
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Query: 575 ----LEQNEA----LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
LE+N L+ + + +I + V +EL K E K+ +L +
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKL-----QALANEQAA-------AAHELEK-MQQ 673
R+ L S++ + + + N L E++K+ + L +EQ+ +LE +++
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 674 SVYVKDDKIRLLEEQLQHEISNKME---EFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
S+ +K++KI LE +L+ + + E K + +ALK + + + S P
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----Q 786
+ E+ QE +L V++ L AT + E A++T+ L + +L+A+ Q
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLL 846
VS ++E + ++ K++ L ++ + N+ + + +S E ++++
Sbjct: 1088 RQTVS----LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Query: 847 KGKEEQMNTMKAVLEEKEK-DLANT--GKWLQDLQEENESLK-AHVQ-EVAQHNLKEA-- 899
K +E+ + +++++ EK +L + + L ++ +LK AH EV +L++
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 900 ---SSASQFEELEIVLKEKENEL----KRLEAMLKER-----ESDLSSKT--QLLQD--- 942
Q E+LE +LK ++ ++ K E + E E+D + T QLL++
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263
Query: 943 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1002
+Q ++K KS + K + + + F +E + + +++ L LK +E +
Sbjct: 1264 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323
Query: 1003 RK-----------KNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1045
+ +N L E+N E+ + ++ DK+N+ +++++ E +
Sbjct: 1324 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 152 bits (384), Expect = 2e-36
Identities = 233/1130 (20%), Positives = 488/1130 (43%), Gaps = 189/1130 (16%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVI--------------QD 317
T+ +E+ E K+ L LK ++ DE + +++L +E+ G+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 318 ALKKS------------SKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
+K++ +K ++ L +L+EK + L K++ + K+L QE M
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 366 KERSNVVITRM-KDRIGTL-EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
S+ RM +D + L EK V + + VS + + ++F + R + LK
Sbjct: 299 L--SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR------VEELK 350
Query: 424 QENGILRDAVSNTTNQLESKQ--SAELNKLRQDYARLVN-----ELTEKTGKLQQEEVQK 476
++N +L + + +QLE + S +L++L ++ +L E+ + + EE+ +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAE-HEAAQQDL--------QSKFVAKEN 527
+N Q + + WE Q RT+E EA Q+ L S+ + E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQI---SRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL------ 581
E QSL + + + +E ++++ E++ + +++ +I+++ ++L
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 582 -------KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
KAQ+++ + + + K++ ++++ + QT SL +R ++ S E
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQI------KILEQENEHLNQTVSSLR-QRSQI-SAE 579
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EI 693
+KDI+ N +L +++ + ++ +++K + K ++ LE +L H E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
N++ + KI N LK +K++ L EQ N + ++ ++ KLK + +
Sbjct: 640 ENELLQKKITN-----LKITCEKIEAL--EQENSE--------LERENRKLKKTLDSFKN 684
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Q+ + E+E + + EN L + V+ LK + A L E K++ EK+ ++K
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCAS---MKMAQLQLENKELESEKE-QLKKG 740
Query: 814 EELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 873
ELL+A K E + Q + + Q LQ L+ +++ +++ L++ E +
Sbjct: 741 LELLKASFKKTERLEVSYQ-GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN------ 793
Query: 874 LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL 933
Q LQ+ E LK + + Q + S + +LE K+ E E KRL + +++ L
Sbjct: 794 -QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 934 SSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 993
+ +++ ENK +I K+ + ++EL+K + K + L +L
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 994 SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVL 1053
S K + NNDL + E + + E++L D+ + + + +E + + L
Sbjct: 913 SEKLKTQQM---NNDLEKLTHELEKIGLNKERLLHDE-----QSTDDRYKLLESKLESTL 964
Query: 1054 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
KK + KE E++ LE +L+E+ + L+ E
Sbjct: 965 KKSL--------------------EIKE--------EKIAALEARLEESTNYNQQLRQEL 996
Query: 1114 EKYKS---VLAETEGILQKLQRS--VEQEENKWKVKVDESHKTIKQMQSSFTSSEQ---- 1164
+ K L + + + +Q S + E+NKW+ + E+ + + +++ E+
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 1165 ---ELERLRSENKDIE------------------NLRREREHLEMELEKAEMERSTYVTE 1203
E + L+++ K +E +L+ + L+ + K ++E ST ++
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 1204 VRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP 1263
L Q + L + + +NE + V K ++ L+ + ++K E ++
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVI----KEREDLKSLYDSLIKDH------EKLELLH 1166
Query: 1264 ETESSEKETMSVSLNQTVTQLQQLLQAVNQ-------QLTKEKEHYQVLE 1306
E ++SE E++ +S + T+ + L+ ++ QL K+K + LE
Sbjct: 1167 ERQASEYESL-ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215
Score = 129 bits (323), Expect = 2e-29
Identities = 238/1133 (21%), Positives = 496/1133 (43%), Gaps = 147/1133 (12%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHE-SDSESVPRDFKLSDALAVEDDQVA 98
+Q+ E+K K++ E+ + + K +Q N++ SD+ S DAL + +V
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVD 323
Query: 99 PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEA 158
+ V S +ER + K +EE +KE + + K + + +
Sbjct: 324 KLESEV----SRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 159 AASKKKPGQKKSKNGSDDQD-----KKVETLM-------VPSKRQEALPLHQETKQESGS 206
+K+ Q K+K + + KK+E LM + K+ LH + E S
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
Query: 207 GKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKS 266
+ S QK+ V+E + + + + + V + R +D VEG +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD-----SVEG---N 489
Query: 267 GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV---VDLLKEKSGVIQ--DALKK 321
+K LK E KEN + K +L + + + C DL+KEK+ + + + L++
Sbjct: 490 ASKILKME--KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRM---- 376
+S+ ++ L + + ++ ++++++ + + + R K + +E E +++
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 377 -KDRIGTLEKEH--------NVFQNKIHVSYQETQQMQMKFQQVR------EQMEAEIAH 421
+ R E EH +N++H +E + +Q K ++ E +E E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 422 LKQENGILR---DAVSNTTNQLES--KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
L++EN L+ D+ N T QLES K++++L++ + R V L + K+ Q +++
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 477 KNAEQAATQLKVQLQ------------EAERRWEEVQSYIRKRTAEHEAAQ-QDLQSKFV 523
K E QLK L+ E + ++++ ++T E+ + Q L+S+
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 524 AKENEVQSLHSKLTDTLVSKQQLEQ---------RLMQLMESEQKRVNKEESLQMQVQDI 574
E E Q+L L + +S ++LEQ + +E ++K++ KE Q +I
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Query: 575 ----LEQNEA----LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
LE+N L+ + + +I + V +EL K E K+ +L +
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKL-----QALANEQAA------AAHELEK-MQQS 674
R+ L S++ + + + N L E++K+ + L +EQ+ +LE +++S
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 675 VYVKDDKIRLLEEQLQHEISNKME---EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731
+ +K++KI LE +L+ + + E K + +ALK + + + S P
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QN 787
+ E+ QE +L V++ L AT + E A++T+ L + +L+A+ Q
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087
Query: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLK 847
VS ++E + ++ K++ L ++ + N+ + + +S E ++++K
Sbjct: 1088 QTVS----LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Query: 848 GKEEQMNTMKAVLEEKEK-DLANT--GKWLQDLQEENESLK-AHVQ-EVAQHNLKEA--- 899
+E+ + +++++ EK +L + + L ++ +LK AH EV +L++
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 900 --SSASQFEELEIVLKEKENEL----KRLEAMLKER-----ESDLSSKT--QLLQD---V 943
Q E+LE +LK ++ ++ K E + E E+D + T QLL++ +
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263
Query: 944 QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1003
Q ++K KS + K + + + F +E + + +++ L LK +E +
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323
Query: 1004 K-----------KNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1045
+ +N L E+N E+ + ++ DK+N+ +++++ E +
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
Score = 93.2 bits (230), Expect = 1e-18
Identities = 195/957 (20%), Positives = 387/957 (40%), Gaps = 135/957 (14%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVED 94
+E+L K+ K+ +K +A +++N + E +N L ++ F+L ++L E+
Sbjct: 641 NELLQKKITNLKIT---CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKEN 696
Query: 95 DQVAPVPLNVVETSSSVRERKKK------EKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
Q+ L + S++ K E K+ +EQ+ K + K KK E + V
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
Query: 149 TKQPTPPSEAAASK--KKPGQKKSKNGSDDQD---------KKVETLMVPSKRQEALP-- 195
+ Q K + +K + S+ QD K +E L + SKR E L
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 196 ---LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVI 252
L QET Q K+ K+ + + + + + N + +E+
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV--KIGNLEKENKTLSKEI- 873
Query: 253 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKS 312
GI K +LK E +KEN E+ K + +KT++ + DL+ EK
Sbjct: 874 ---------GIYKESCVRLK-ELEKENKEL-VKRATIDIKTLVTLRE------DLVSEKL 916
Query: 313 GVIQDALKKSSKGELTTLIHQLQE----KDKLLAAVKEDAAATKDRCKQLTQEMMTEKER 368
Q +L L H+L++ K++LL D +T DR K L ++ + ++
Sbjct: 917 KTQQ------MNNDLEKLTHELEKIGLNKERLL----HDEQSTDDRYKLLESKLESTLKK 966
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
S + +++I LE ++ S QQ++ + + V++ EA LKQ
Sbjct: 967 SLEI---KEEKIAALEA-------RLEESTNYNQQLRQELKTVKKNYEA----LKQRQDE 1012
Query: 429 LRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV 488
R S+ S E NK ++ EL + +L + E + LK
Sbjct: 1013 ERMVQSSPPI------SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066
Query: 489 QLQEAERRWEEVQSYI---RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
QL++ E + +Q+ I +++T + LQ++ + E +L+S+ T + Q
Sbjct: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Query: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
L + L + + + E L+ +++ +E L+ H + A++ + +
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL----LHERQASEYESLI---SK 1179
Query: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
H + K ++ L ++L ++ +L+D++ M LK E +K+ A
Sbjct: 1180 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM---LKVEQEKMLLENKNHETVA 1236
Query: 666 HELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV--QKLQTLVSE 723
E +K+ ++L H S ++E ++L +K LKS + KL+ E
Sbjct: 1237 AEYKKLCGE-----------NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 724 QPNKDVVEQMEKCIQEKDEKLKTVEELLE--TGLIQVATKE--EELNAIRTENSSLTKEV 779
+ EQ ++ + KL ELL G ++ + +++ + +N +L +
Sbjct: 1286 AEFSKLKEQYQQ-LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE-- 1342
Query: 780 QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKV 839
Q++++K V +++L ++ +K+ K E++++ + + IT K+
Sbjct: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKE---KLEEKIMDQYKFYDPSPPRRRGNWITLKM 1399
Query: 840 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 899
++L + + K + E++K L T ++S + +Q Q + +
Sbjct: 1400 RKL----------IKSKKDINRERQKSLTLT-------PTRSDSSEGFLQLPHQDSQDSS 1442
Query: 900 SSASQFEELEIVLKEKENELKRLEAM--LKERESDLSSKTQLLQDVQDENKLFKSQI 954
S S E L K++ + L+ + L+ R D + N L +S +
Sbjct: 1443 SVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV 1499
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 152 bits (383), Expect = 3e-36
Identities = 231/1063 (21%), Positives = 464/1063 (43%), Gaps = 139/1063 (13%)
Query: 320 KKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDR 379
+ S G LT + K A++E A K++ +Q ++++ E++ + +
Sbjct: 329 RPSRTGLLTETSSRYARKISGTTALQE---ALKEK-QQHIEQLLAERDLERAEVAKATSH 384
Query: 380 IGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAE-------IAHLKQENGILRDA 432
+G +E+E + ++ Q +++ K Q+R +EA + L++E + D
Sbjct: 385 VGEIEQELALARDGHD---QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDL 441
Query: 433 V------SNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL 486
S T LE++ E ++++ L+ E T K KLQ+E ++ A
Sbjct: 442 QFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKT-KADKLQRE---LEDTRVATVSE 497
Query: 487 KVQLQEAER----RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS 542
K ++ E E+ R +EV R+ + A D+ + E+ SL KL T
Sbjct: 498 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL---QEISSLQEKLEVTRTD 554
Query: 543 KQQLEQRLMQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Q+ L + + ++ KE ++L + + ++NE+LK++++ H+ ++
Sbjct: 555 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLE--HANKENSDVIALW 612
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK-DIQNMNFLLKAEVQKLQALAN- 659
+L IA + +++ + S + T++ ELK I+ M + E++ LQ +
Sbjct: 613 KSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 672
Query: 660 EQAAAAHELE----KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
E+AA A E+E K+ + + K++ + + +L + E + ++ + + +V+
Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732
Query: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE-LLETGLIQVATKE--EELNAIRTEN 772
+L+ L ++ + K I +LK EE LL+ ++ A+ E E+ +R +
Sbjct: 733 ELEVLQAK------CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 786
Query: 773 SSLTKEVQDLKAKQNDQVSFASLV------EELKKV-IHEKDGKIKSVEELLEAELLKVA 825
+ K+++ L+ ++N + S AS + ELK + E ++ V+E LE EL +
Sbjct: 787 EAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL- 845
Query: 826 NKEKTVQ-----LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT-GKWLQDLQE 879
KEK + +S+ +QE N L KEEQ N + + LE+ ++LA+ K+ + +
Sbjct: 846 -KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904
Query: 880 ENESLKAHVQ---EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAML---------- 926
E + +KA + ++A+ ++SQ ++ L+ KE +++ L+ L
Sbjct: 905 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 964
Query: 927 -------------------KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 967
K+ E + + L D++ + + +Q ++LK + Y++A+S
Sbjct: 965 QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATS 1023
Query: 968 FPP--HEELL----KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALA 1021
HEE+L K + + E ++ G E L +E RK+ + + A +A+
Sbjct: 1024 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ-TAEDAMQ 1082
Query: 1022 STEKMLQDKVNK-TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY------GEWLHG 1074
E+M ++K S E +Q A + LK+ K N S + +
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1142
Query: 1075 FEKKAKEC-MAGTSGSEEVKVL-EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1132
F K+ + A S+++ L E +K A+E+ K L E +L
Sbjct: 1143 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVLNNQLL 1200
Query: 1133 SVEQEENKWKVKVDES----HKTIKQMQSSFTSSEQELERLRS-------ENKDIENLRR 1181
+++ E+K+ DE K+I + T + ELE+LR+ EN ++L
Sbjct: 1201 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
Query: 1182 EREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQK-----------VAG 1230
+ LE + K E++ +++E K QL+ + T+ +E ++ V
Sbjct: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
Query: 1231 DLHKAQQSLELIQSKIVKAA--GDTTVIENSDVSPETESSEKE 1271
DL + Q L++ + +AA G+ + N D + + S+K+
Sbjct: 1321 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKK 1363
Score = 126 bits (317), Expect = 1e-28
Identities = 199/920 (21%), Positives = 395/920 (42%), Gaps = 173/920 (18%)
Query: 247 DKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVK-FKDFLLSLKTMMFSEDEAL--C 303
+KR+V DL + E I K L+T+T E+A +K + LL KT L
Sbjct: 434 EKRKVEDLQFRVEEESITKGD---LETQTKLEHARIKELEQSLLFEKTKADKLQRELEDT 490
Query: 304 VVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM 363
V + EKS +++ L+K +L + ++ E + L + K A D L QE+
Sbjct: 491 RVATVSEKSRIME--LEK----DLALRVQEVAELRRRLESNKP--AGDVDMSLSLLQEIS 542
Query: 364 TEKERSNVV-------ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME 416
+ +E+ V IT +K+ G E+ H Q +I Y T+ K + E ++
Sbjct: 543 SLQEKLEVTRTDHQREITSLKEHFGAREETH---QKEIKALYTATE----KLSKENESLK 595
Query: 417 AEIAHLKQENGI--------LRDAVSNTTNQLE-----------------SKQSAELNKL 451
+++ H +EN L A+++ +E ++ ++ K+
Sbjct: 596 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 655
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEH 511
R DY + L + + K E +L ++E E E ++S + K +H
Sbjct: 656 RLDYQHEIENLQNQQDS--ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 713
Query: 512 EAAQQDLQSKFVAKENEVQSLH---------SKLTDTLVSKQQLEQRLMQLMESEQKRVN 562
+D +K E +V+ L +K+ D S+ + + + +++ +K +
Sbjct: 714 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 773
Query: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS-ASVLAEELH------KVIAEKDKQ 615
+ +S +++ + +Q EA + QI+ + A++S AS + EL + E +
Sbjct: 774 EGKS---EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 616 IKQTEDSLASE----RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKM 671
+ Q +++L E +++ EE +Q ++ V KL + + +LEK+
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRS---MQETVNKLHQKEEQFNMLSSDLEKL 887
Query: 672 QQSVYVKDDKIR----------LLEEQLQHEISNKME-------EFKILNDQNKALKSEV 714
++++ + K R +E+L+++I+ M+ + +ND+ + + +V
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 947
Query: 715 QKLQ--------------------TLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETG 754
++LQ T+ +EQ ++ ++ E+ +E + KL +E+ +ET
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETS 1007
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
Q +EL A R E ++ + + + QN Q + ++LK E G ++ +E
Sbjct: 1008 HNQC----QELKA-RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1062
Query: 815 ELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 874
EL K A+K K Q + E+ M M+ + +EK + LA+ L
Sbjct: 1063 ELR-----KQADKAKAAQTA---------------EDAMQIMEQMTKEKTETLAS----L 1098
Query: 875 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 934
+D ++ N L+ + + ++NLK ++ +EL V +K E ++ LK+ +
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA---AA 1155
Query: 935 SKTQLLQDVQDEN-----KLFKSQIEQLKQQNYQQASSFPPHEEL------LKVISEREK 983
K+Q L +Q+EN +L +S+ E Q ++ S ++ L K I + ++
Sbjct: 1156 QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADE 1215
Query: 984 EISGLWNELD------SLKDA-VEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSK 1036
E + L + + KDA +E R + LR +N A + + + DKV
Sbjct: 1216 EKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKV----- 1270
Query: 1037 ERQQQVEAVELEAKEVLKKL 1056
+ + +V+ +EL+ KE ++L
Sbjct: 1271 KLELKVKNLELQLKENKRQL 1290
Score = 118 bits (295), Expect = 4e-26
Identities = 161/766 (21%), Positives = 340/766 (44%), Gaps = 91/766 (11%)
Query: 596 TSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE----V 651
T A A + +V+A +K++ AS ++S + + LL
Sbjct: 287 TPAKAKANAVRRVMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH--EISNKMEEFKILNDQNKA 709
+K+ Q A + + ++Q + +D + + + H EI ++ + +DQ+
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 710 -LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK----DEKLKTVEELLETGLIQVATKEEE 764
L++++ +L+T+V E +++ VE + + +EK D + + EE + G ++ TK E
Sbjct: 405 ELEAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
Query: 765 LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIH-EKDGKIKSVEELLEAELLK 823
E S L ++ + K ++ + + + V E +++ EKD ++ V+E+ E
Sbjct: 464 ARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALR-VQEVAELRRRL 522
Query: 824 VANK---EKTVQLSITSKVQELQNLLK----GKEEQMNTMK----AVLEEKEKDLANTGK 872
+NK + + LS+ ++ LQ L+ + ++ ++K A E +K++
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
Query: 873 WLQDLQEENESLKAHVQEVAQHNLKEASSASQF--EELEIVLKEKENELKRLEAML-KER 929
+ L +ENESLK+ ++ H KE S +LE + + ++ L+ K
Sbjct: 583 ATEKLSKENESLKSKLE----HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
Query: 930 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE-----LLKVISEREKE 984
++ + +L ++ ++ +IE L+ Q + ++ E L+KVI E+E
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
Query: 985 ISGLWNELDSLKDA--VEHQRKKNN----DLREKNWEAMEALASTEKMLQDKVN---KTS 1035
+ + ++LD +D VE + N +++ K E ++A + + + D K +
Sbjct: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 1036 KERQQQVEAVEL---EAKEVLKKLFPKV-SVPSNLSYGEWLHGFEKKAKECMAGTSGSE- 1090
+E+ ++A+ E K +KKL ++ + + + E EK A+ A + E
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITREL 814
Query: 1091 ---EVKV--LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1145
E+K+ L+ L E ++ L+ E + K AE +QRS+++ NK
Sbjct: 815 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK----- 869
Query: 1146 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1205
+ Q + F +LE+LR D+E RE++ E +L KA+ + + E+
Sbjct: 870 ------LHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 1206 ELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS--DVSP 1263
++ + LTK+ E L ++ +E +Q K+ KA + + ++ S D++
Sbjct: 924 KMSGDNSSQLTKMNDE----------LRLKERDVEELQLKLTKANENASFLQKSIEDMTV 973
Query: 1264 ETESSEKETM------SVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
+ E S++E L + ++ L++ ++ + Q + K Y+
Sbjct: 974 KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 1019
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 152 bits (383), Expect = 3e-36
Identities = 270/1366 (19%), Positives = 570/1366 (41%), Gaps = 198/1366 (14%)
Query: 39 AKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDF-KLSDALAVEDDQV 97
A QK++QK+ KT+ +++ + EI ES+ + K+S L V++ QV
Sbjct: 47 ALQKQKQKVENEKTEGTNLKRENQRLMEI---------CESLEKTKQKISHELQVKESQV 97
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLE--EQVIKESDASKIPGKKVEPVPVTKQPTPP 155
+ + + +++ K+ K LE +Q + +D S P + + T P P
Sbjct: 98 NFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTT--PLTP 155
Query: 156 SEAAASKKKPGQKKSKNGSDDQDKKVET---LMVPSKRQEALPLHQETKQESGSGKKKAS 212
S+ + K K+ N ++ K++E + K + LP Q T + +AS
Sbjct: 156 SQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLP--QATMNHRDIARHQAS 213
Query: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSS------PVVDKREVIDLLKPDQVEGI-QK 265
S + L + P+ + +S V R + + K D
Sbjct: 214 SSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDN 273
Query: 266 SGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
S + L + +N E++ K L L+ ++ +K + Q+ + K
Sbjct: 274 SSSPHLLDQLKAQNQELRNKINELELRLQGHEKE--------MKGQVNKFQELQLQLEKA 325
Query: 326 ELTTLIHQLQEKDKLLAAVKE---------DAAATK-----DRCKQLTQEMMTEKERSNV 371
++ +L EK+K+L ++ D A+TK + K+LT+++ +++ +
Sbjct: 326 KV-----ELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
Query: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILR- 430
++ +I EKE FQ ++ + Q + + Q++ ++ E+ K + +L+
Sbjct: 381 ARCSLEQKIKEKEKE---FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437
Query: 431 --DAVSNTTNQLESKQSAELNKL-RQDYARLVNELTEKTGKLQQEEVQKKN------AEQ 481
D +++ QLE+ KL R + A +++ E + EE++K+N +EQ
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Query: 482 AATQ---LKVQLQEAERRWEEVQSY---IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535
A + L+ +L+ ++ + Q++ ++ + E +DLQ K +EN + K
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 536 LTDTLVSKQQ-LEQRLMQLMESEQKRVN-KEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
L + KQ+ Q L++ E +++N K + + + +L E K + ++ +
Sbjct: 558 LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE-- 615
Query: 594 AQTSASVLAEELHKVIAEKDKQ-------IKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
+T S E K++ + + + I E L +++ + E ++ ++
Sbjct: 616 -KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN 674
Query: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
L E++ L + + ++ E+E + + K +++ Q EI N + L Q
Sbjct: 675 LSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELN 766
+ L+ KLQ L +E +KD +C Q+ + +++ +LL++ + T E+
Sbjct: 732 VEDLE---HKLQLLSNEIMDKD------RCYQDLHAEYESLRDLLKSKDASLVTNEDHQR 782
Query: 767 AIRT----------------ENSSLTKEVQD--LKAKQN-----------DQVSFA-SLV 796
++ E S+ E + L+A Q+ D + F+
Sbjct: 783 SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQ 842
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856
+++ + ++ ++ ++ +E L+K ++ + ++ +LQ + +
Sbjct: 843 KQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAET 902
Query: 857 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916
+ LE KEK+ LQ L ++ E+ +A +QE+ + N S + + L L ++
Sbjct: 903 LSALENKEKE-------LQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEK 955
Query: 917 NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK 976
E+ + ++ K +L+ + L+++ + + Q K Q++ SF +
Sbjct: 956 KEMSSIISLNKREIEELTQENGTLKEI-------NASLNQEKMNLIQKSESFANY----- 1003
Query: 977 VISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSK 1036
I EREK IS L D + ++ E+ A E L+ K Q+K +K
Sbjct: 1004 -IDEREKSIS-------ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
Query: 1037 ERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLE 1096
+ E K L++L F K+ +E + + +EE +
Sbjct: 1056 LLNECTSLCE-NRKNELEQL---------------KEAFAKEHQEFLTKLAFAEERN--Q 1097
Query: 1097 HKLKEADEMHTLLQLE-CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD----ESHKT 1151
+ + E + + L+ E + + +E G+ Q++ ++++E+NK + +V+ E+ +
Sbjct: 1098 NLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM-TLKEEQNKMQKEVNDLLQENEQL 1156
Query: 1152 IKQMQSSFTSSEQELERLRSENKDIENLRREREHL-EMELEKAEMERSTYVTEVRELKAQ 1210
+K M++ E E +R+ K+ E+ R + +M+LE E+ +Y ++ +L+A
Sbjct: 1157 MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAM 1216
Query: 1211 LNETLTKLRTE-------QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV-IENSDVS 1262
L KL+ Q+E Q + GDL + +L+ +QS+ + D + E +S
Sbjct: 1217 LRNKELKLQESEKEKECLQHELQTIRGDLETS--NLQDMQSQEISGLKDCEIDAEEKYIS 1274
Query: 1263 P----ETESSEKETMSVSLNQTVTQLQQL------LQAVNQQLTKE 1298
T ++ + SL T+ +L +L LQA +L E
Sbjct: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Score = 137 bits (344), Expect = 9e-32
Identities = 223/1075 (20%), Positives = 476/1075 (44%), Gaps = 148/1075 (13%)
Query: 291 LKTMMFSEDEALCVVDLLKEKSGVIQDALK-KSSKGELTTLIHQLQEKDKLLAAVKEDAA 349
+ + FS AL +D L + + L+ K + E L+H ++++D+ + ++ +
Sbjct: 1746 ISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
Query: 350 ATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV---SYQETQQMQM 406
+ ++MT+ E ++ +G L+KE++ K+ +QE Q
Sbjct: 1806 ELDSKLHLQEVQLMTKIE----ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 407 KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESK---QSAELNKLRQDYARLVNEL- 462
+ + +E +E+ + D V+ + + + EL+++R + A + +E
Sbjct: 1862 TSEGLNSDLEMHADKSSRED--IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 463 ----------TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHE 512
TEK + E ++K +L V E + E+ + +K TA +
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTL-VSKQQLEQR--LMQLMESEQKRVNKEES-LQ 568
L K K E++S S+ + V++ +++++ L+Q + S+ + K+++ LQ
Sbjct: 1980 -----LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQ 2034
Query: 569 MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628
++Q + + ++AL + +QIA +L+K EK+ +K++E A
Sbjct: 2035 EKLQSLEKDSQALSLTKCELENQIA----------QLNK---EKELLVKESESLQA---- 2077
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRL---L 685
RL+ + E N++ L+A + + A ++ E+ ++++ + +K+R+
Sbjct: 2078 RLSESDYEKL---NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI----EKLRVRIEA 2130
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
+E+ Q I+ K++E + ND K D VE +E+ +Q +E +
Sbjct: 2131 DEKKQLHIAEKLKERERENDSLK-------------------DKVENLERELQMSEENQE 2171
Query: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
V ++ + E+ ++T+ + + LK + D V+ S E L K I E
Sbjct: 2172 LV-------ILDAENSKAEVETLKTQIEEMARS---LKVFELDLVTLRSEKENLTKQIQE 2221
Query: 806 KDGKIKSVEELLEAELLKVANKEKT-VQLSITSK--VQELQNLLKGKEEQMNTMKAVLEE 862
K G++ +++LL + + KE+ +Q+ SK V+ LQN LK ++N A L
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK----ELNEAVAALCG 2277
Query: 863 KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRL 922
++ + T + L EE L+ ++++ EA Q L+ LKE E+ L
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR--LEADEKKQLCVLQ-QLKESEHHADLL 2334
Query: 923 EAMLK--ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE-ELLKVIS 979
+ ++ ERE +++ Q ++ EN K ++E LK + S E +++ + S
Sbjct: 2335 KGRVENLERELEIARTNQEHAALEAENS--KGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 980 EREKEISGLWNELD----------SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1029
E+E + L E + S ++ ++ + ++ ++EK+ AME L + K L +
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNE 2452
Query: 1030 KV------NKTSKERQQ----QVEAVELEAKEVLKKL------FPKVSVPSNLSYGEWLH 1073
+V + K ++Q QVE +ELE ++L+ L + + N E
Sbjct: 2453 RVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVED 2512
Query: 1074 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1133
G +K K+ EE+ L++++++ +++ + L + E + E L+ L
Sbjct: 2513 GKQKLEKK-------DEEISRLKNQIQDQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVE 2564
Query: 1134 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKA 1193
+EQ+ + K T++ +QSS+ + E ELE + + + E EL++
Sbjct: 2565 LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQRE 2624
Query: 1194 EMERSTYVTEVRE--------LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1245
E + E++E L +L L ++++ +++ +++ + + ++SL+ +
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Query: 1246 IVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1300
V+ G E ++ +EK+ ++ L+ T Q + +Q ++LT ++E
Sbjct: 2685 QVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLD-TNKQYEVEIQTYREKLTSKEE 2737
Score = 130 bits (326), Expect = 1e-29
Identities = 167/792 (21%), Positives = 357/792 (45%), Gaps = 84/792 (10%)
Query: 269 KKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELT 328
+KLK E ++EN +K K L + M E++ L ++D ++SK E+
Sbjct: 2140 EKLK-ERERENDSLKDKVENLERELQMSEENQELVILDA-------------ENSKAEVE 2185
Query: 329 TLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHN 388
TL Q++E + L + D + + LT+++ EK+ + ++ +L +E
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ-EKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 389 VFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAEL 448
Q +I + + ++M Q++E EA +A L + I++ + +E +
Sbjct: 2245 --QAEIQIKEESKTAVEMLQNQLKELNEA-VAALCGDQEIMKATEQSLDPPIEEEHQLR- 2300
Query: 449 NKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRT 508
N + + ARL + ++ LQQ K +E A LK +++ ER E ++
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQ----LKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 509 AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568
E E ++ ++++ E QSL D + + + E L ++ EQ+R+++ E +
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN-LTNELQKEQERISELEIIN 2415
Query: 569 MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628
++IL++ E K Q+++ S T+ +L +L K + E+ + +++ ++
Sbjct: 2416 SSFENILQEKEQEKVQMKEKSS-----TAMEMLQTQL-KELNERVAALHNDQEACKAKEQ 2469
Query: 629 RLTSKEE--ELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE 686
L+S+ E EL+ Q + L +A+ + L + E+E +Q + KD++I L+
Sbjct: 2470 NLSSQVECLELEKAQLLQGLDEAKNNYI-VLQSSVNGLIQEVEDGKQKLEKKDEEISRLK 2528
Query: 687 EQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKT 746
Q+Q + + + + +++ K + +L+ L E +EQ + +Q K+ L+
Sbjct: 2529 NQIQDQ-EQLVSKLSQVEGEHQLWKEQNLELRNLTVE------LEQKIQVLQSKNASLQD 2581
Query: 747 VEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK 806
E+L++ + E EL + + S ++V + AK+ EL++ +HE
Sbjct: 2582 TLEVLQSSYKNL---ENELELTKMDKMSFVEKVNKMTAKET----------ELQREMHEM 2628
Query: 807 DGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLE---EK 863
K ++E L E ++A + + + I S +L+ L E ++ + + EK
Sbjct: 2629 AQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688
Query: 864 E----KDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 919
E +++A L + ++++++L + Q+ ++ + + E L ++ E+
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNK--QYEVEIQTYREKLTSKEECLSSQKLEI 2746
Query: 920 KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS 979
L++ +E + L + TQ+L++++ + QLK++N + + L+K
Sbjct: 2747 DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM---KLLIKSCK 2803
Query: 980 EREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQ 1039
+ E+E L EL L+ A E Q+ T ++ KV++ + E +
Sbjct: 2804 QLEEEKEILQKELSQLQAAQEKQK-------------------TGTVMDTKVDELTTEIK 2844
Query: 1040 QQVEAVELEAKE 1051
+ E +E + KE
Sbjct: 2845 ELKETLEEKTKE 2856
Score = 112 bits (281), Expect = 2e-24
Identities = 212/983 (21%), Positives = 413/983 (42%), Gaps = 145/983 (14%)
Query: 399 QETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARL 458
+E + + ++Q E++E ++ + GI+++ QL S + EL+ LR+ Y
Sbjct: 1550 EELESLCEVYRQSLEKLEEKM----ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSE 1605
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAAT-QLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQD 517
+ +K + E K AE+ T QL ++L+ A + + + D
Sbjct: 1606 NEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGL----------------D 1649
Query: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV---NKEESLQMQVQDI 574
L S+ + + ++ + +SK+ + + + + ++ + ++ L + ++ I
Sbjct: 1650 LSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKI 1709
Query: 575 LEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
E A+K + Q + T+ E+ + +E ++ + + D L ++E
Sbjct: 1710 TETG-AVKPTGECSGEQ-SPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE 1767
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEIS 694
DI N+ +K + L + ++E + + D K+ L E QL +I
Sbjct: 1768 ----DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE 1823
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTL------------VSEQPNKDVVEQMEKCIQEK-D 741
+E KI+ + K +KL+ SE N D+ +K +E
Sbjct: 1824 ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIG 1883
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKA---------------KQ 786
+ + V + + + V E EL+ IR+E +S+ E L+A +
Sbjct: 1884 DNVAKVNDSWKERFLDV---ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE 1940
Query: 787 NDQVSFASLVEELKKVIHEKD---GKIKSVEELLEA-ELLKVANKEKTVQLSITSK---- 838
N Q L EEL V E++ G++ ++ + A + L KEKT +L
Sbjct: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000
Query: 839 -VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL---KAHVQ-EVAQ 893
+Q + +K K E + T+ + + E KD + + LQ L++++++L K ++ ++AQ
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQ 2060
Query: 894 HNLKEASSASQFEELEIVLKEKE----NELKRLEAMLKERESDLSSKTQLLQDVQDENKL 949
N ++ + E L+ L E + N K LEA L E+ L Q+E
Sbjct: 2061 LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK----GEFALRLSSTQEEVHQ 2116
Query: 950 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1009
+ IE+L+ + E LK ERE+E L +++++L+ ++ ++N +L
Sbjct: 2117 LRRGIEKLRVRIEADEKKQLHIAEKLK---ERERENDSLKDKVENLERELQ-MSEENQEL 2172
Query: 1010 REKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYG 1069
+ E +A T K +++ ++ K + + + E + + K++ K S L
Sbjct: 2173 VILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD-- 2230
Query: 1070 EWLHGF-----EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETE 1124
+ L F EK+ E V++L+++LKE +E L + E ++ TE
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE----IMKATE 2286
Query: 1125 GILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE----LERLRSENKDIENLR 1180
Q L +E+E + +I+++++ + E++ L++L+ + L+
Sbjct: 2287 ---QSLDPPIEEEH--------QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK 2335
Query: 1181 REREHLEMEL-------EKAEMERSTYVTEVRELKAQLNETLTKLR-------TEQNERQ 1226
E+LE EL E A +E EV LKA++ LR T ++E++
Sbjct: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKE 2395
Query: 1227 KVAGDLHKAQQ---SLELIQSKIVKAAGDTTVIENSDVSPETESSE-KETMSVSLNQTVT 1282
+ +L K Q+ LE+I S EN E E + KE S ++ T
Sbjct: 2396 NLTNELQKEQERISELEIINSS----------FENILQEKEQEKVQMKEKSSTAMEMLQT 2445
Query: 1283 QLQQLLQAV-----NQQLTKEKE 1300
QL++L + V +Q+ K KE
Sbjct: 2446 QLKELNERVAALHNDQEACKAKE 2468
Score = 111 bits (277), Expect = 5e-24
Identities = 224/1086 (20%), Positives = 446/1086 (41%), Gaps = 171/1086 (15%)
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
AL++ +G T + ++QE + L +K++ + + L + +K++ T
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-- 61
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQ-----MQMKFQQVREQMEAEIAHLKQENGILRDA 432
GT K N +I S ++T+Q +Q+K QV Q E ++ K++ L
Sbjct: 62 ---GTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQ-EGQLNSGKKQIEKLEQE 117
Query: 433 VSNTTNQLESKQSA------ELNKLR---------------------QDYARLVNELTEK 465
+ ++LE Q A LN +D N+ E+
Sbjct: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177
Query: 466 TGKLQQE--EVQKKNAEQAATQLKVQLQEAERRW--EEVQSYIRKRTAEHEAA------- 514
+L+ E +Q K A Q Q + ++ R V S+ +++T H ++
Sbjct: 178 RKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPI 237
Query: 515 QQDLQSKFVAKENEVQSLHSKL-------TDTLVSKQQLEQRLMQLMESEQKRVNKEESL 567
++D + + + E EV S L + L QL Q+ NK L
Sbjct: 238 RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Query: 568 QMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLA--- 624
++++Q + +K Q+ +F + E+ + EK+K + + D L
Sbjct: 298 ELRLQG---HEKEMKGQVNKFQE-------LQLQLEKAKVELIEKEKVLNKCRDELVRTT 347
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRL 684
++ D+ ++K L+ QKL+ L + + E + S+ + KI+
Sbjct: 348 AQYDQASTKYTALE-------------QKLKKLTEDLSCQRQNAESARCSL---EQKIKE 391
Query: 685 LEEQLQHEISNKMEEFKILNDQNKALKSEV-QKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
E++ Q E+S + F+ L+ + +K+ + Q+LQ + M +Q + +K
Sbjct: 392 KEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ----------AKNMHNVLQAELDK 441
Query: 744 LKTVEELLETGLIQVATK----EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEEL 799
L +V++ LE L + K E+ A + + + L + ++++K + N S + ++
Sbjct: 442 LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE--QKA 499
Query: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAV 859
++V H + ++K++++ L + A + K S + +++LQ + +E + K
Sbjct: 500 REVCH-LEAELKNIKQCLN-QSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLK 557
Query: 860 LE----EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK-EASSASQFEELEIVLKE 914
L EK++D + QDL ++ E H++++ K E S + LE+ KE
Sbjct: 558 LAVADLEKQRDCS------QDLLKKREH---HIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 915 KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ-QNYQQASSFPPHEE 973
E ELK + + +S+ +LL ++ E + +S+I L+ QQ S +E
Sbjct: 609 YE-ELKEEKTLFSCWKSE---NEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER 664
Query: 974 LLKVISEREK---EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1030
+ + +RE EI L N LDS VE Q+ +L++K A S +K ++
Sbjct: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK------AEFSDQKHQKEI 718
Query: 1031 VNKTSKERQQQVEAVELEAK----------------------EVLKKLFPK--VSVPSNL 1066
N K Q + +LE K E L+ L S+ +N
Sbjct: 719 ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNE 778
Query: 1067 SYGEWLHGFEKKAK-----ECMAGTSGSEEVKVLEHKLKEADEM---HTLLQLECEKYKS 1118
+ L F+++ + G GS + E +L EAD+ +LQ + +
Sbjct: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRL-EADQSPKNSAILQNRVDSLEF 837
Query: 1119 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTS-SEQELERLRSENKDIE 1177
L + + LQ+ E E + K +++E+ +QM SF + + Q + +L+ + +
Sbjct: 838 SLESQKQMNSDLQKQCE-ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 1178 NLRRER----EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
N+ E E+ E EL+ + T E++ELK + L+ Q + ++ +
Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKK 956
Query: 1234 KAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQ 1293
+ + L + +I + + ++ + S E S S + + ++ + ++
Sbjct: 957 EMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSD 1016
Query: 1294 QLTKEK 1299
Q +EK
Sbjct: 1017 QYKQEK 1022
Score = 100 bits (249), Expect = 9e-21
Identities = 193/931 (20%), Positives = 373/931 (40%), Gaps = 197/931 (21%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEI---QNGNLHESDSESVPRDFKL 86
K L +++ + +K Q L TK + + + NK+KE+ ++ +L SES +
Sbjct: 2030 KTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV 2089
Query: 87 SDALAVEDDQVAPVPLNVVETSSSVRERKK-----------KEKKQKPVLEEQVIKESDA 135
S AL + L + T V + ++ EKKQ + E+ +E +
Sbjct: 2090 SKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149
Query: 136 SKIPGKKVEPVPVTKQPTPPSE------AAASKKKPGQKKSKNGSDDQDKKVETLMVPSK 189
+ K VE + Q + ++ A SK + K++ + KV L + +
Sbjct: 2150 DSLKDK-VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTL 2208
Query: 190 RQEALPLHQETKQESG---------SGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
R E L ++ +++ G S K +K++ E +E + T + ++ N
Sbjct: 2209 RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE----SKTAVEMLQNQ 2264
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
+ + E + L DQ I K+ + L ++E+ + ++ + L+ + ++++
Sbjct: 2265 ----LKELNEAVAALCGDQE--IMKATEQSLDPPIEEEH---QLRNSIEKLRARLEADEK 2315
Query: 301 A-LCVVDLLKEKS-------GVIQDALKK----------------SSKGELTTLIHQLQE 336
LCV+ LKE G +++ ++ +SKGE+ TL +++
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEG 2375
Query: 337 KDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV 396
+ L ++ D + + LT E+ E+ER I LE ++ F+N +
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQER-----------ISELEIINSSFENILQE 2424
Query: 397 SYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYA 456
QE QM+ K E ++ ++ L + L + E S+++ L + A
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHND-QEACKAKEQNLSSQVECLELEKA 2483
Query: 457 RLVNELTEK-----------TGKLQQEEVQKKNAE---QAATQLKVQLQEAERR------ 496
+L+ L E G +Q+ E K+ E + ++LK Q+Q+ E+
Sbjct: 2484 QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQ 2543
Query: 497 -------WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQR 549
W+E +R T E E Q LQSK + ++ ++ L S + + +
Sbjct: 2544 VEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2603
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL---- 605
M +E K KE LQ ++ ++ ++ L+ ++ +++A + +L EE+
Sbjct: 2604 KMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ--LLLEEIKSSK 2661
Query: 606 --------------------HKVIAEKDKQI--------------------------KQT 619
HK EK+ ++ KQ
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY 2721
Query: 620 EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
E + + R++LTSKEE L + LLK+ ++L N A LE+++++
Sbjct: 2722 EVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELN---NSLKATTQILEELKKT----- 2773
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
KM+ K +N K + K++ L+ +E+ ++ +Q+
Sbjct: 2774 ----------------KMDNLKYVNQLKKENERAQGKMKLLIKSCKQ---LEEEKEILQK 2814
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQV--SFASLVE 797
+ +L+ +E +TG + + TK +EL TE L KE + K K+ D+ + SL+
Sbjct: 2815 ELSQLQAAQEKQKTGTV-MDTKVDELT---TEIKEL-KETLEEKTKEADEYLDKYCSLL- 2868
Query: 798 ELKKVIHEKDGKIKSVEELLEAELLKVANKE 828
+ HEK K K + E A L +K+
Sbjct: 2869 ----ISHEKLEKAKEMLETQVAHLCSQQSKQ 2895
Score = 95.5 bits (236), Expect = 3e-19
Identities = 172/838 (20%), Positives = 339/838 (40%), Gaps = 132/838 (15%)
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ 587
++Q L +L KQQ + +L L + QK+ K E+ + + ++ +N+ L +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77
Query: 588 FHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
S +++ + K+ Q+ E L S + ++ E+ELK
Sbjct: 78 ---------SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK-------RC 121
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQ--------SVYVKDDKIRLLEEQLQHEISNKMEE 699
K+E+++ Q A + + Q+ S Y K E L+ + + ++EE
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKY----EDLKEKYNKEVEE 177
Query: 700 FKILNDQNKALKSEVQKLQTLVSEQPN-KDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
K L + KAL+++ + QTL N +D+ ++ KT L
Sbjct: 178 RKRLEAEVKALQAK-KASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTP 236
Query: 759 ATKEEELN------AIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
++ + + S+L +D + D S L+++LK E KI
Sbjct: 237 IRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINE 296
Query: 813 VEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
+E L++ EK ++ + +K QELQ L+ + ++ + VL + +L T
Sbjct: 297 LE-------LRLQGHEKEMKGQV-NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTA 348
Query: 873 WLQDLQEENESLKAHVQEVAQH-NLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 931
+ +L+ ++++ + + + ++ S LE +KEKE KE +
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE----------KEFQE 398
Query: 932 DLSSKTQLLQDVQDENKLFKSQIEQLKQQ-----NYQQASSFPPHEELLKVISEREKEIS 986
+LS + + Q + E K+++ Q QQ N QA ++L V + E +
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL----DKLTSVKQQLENNLE 454
Query: 987 GLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1046
+L + A + + K N+LR +ME + +L+ S+++ ++V +E
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELR----RSMEEMKKENNLLKSH----SEQKAREVCHLE 506
Query: 1047 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMH 1106
E K + K + + ++ E E KAK TS ++ L+ K+ + +
Sbjct: 507 AELKNI------KQCLNQSQNFAE-----EMKAK----NTSQETMLRDLQEKINQQENSL 551
Query: 1107 TLLQLECEKYKSVLAETE-------GILQKLQRSVEQEENKWKVKVDES----------- 1148
TL EK K +A+ E +L+K + +EQ +K ES
Sbjct: 552 TL-----EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606
Query: 1149 --HKTIKQMQSSFTSSEQELERLRSE-NKDIENLRREREHLEM--------------ELE 1191
++ +K+ ++ F+ + E E+L ++ + ENL+ + HLE +
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 1192 KAEMERSTYVTEVRELKAQLNETLTKLRTEQ----NERQKVAGDLHKAQQSLELIQSKIV 1247
EM+R E+R L L+ ++ T++ +QK K Q+ +E + K
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 1248 KAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1305
+ G +E+ E +K+ L+ L+ LL++ + L ++H + L
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL 784
Score = 90.5 bits (223), Expect = 9e-18
Identities = 144/750 (19%), Positives = 306/750 (40%), Gaps = 73/750 (9%)
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
Q L + D+L KE++ + Q + L+A +QK + + L++ Q +
Sbjct: 18 QKIQELEGQLDKL-KKEKQQRQFQLDS--LEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
+ + ++++ HE+ K + Q + K +++KL+ + K +E+ ++
Sbjct: 75 ICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR--CKSELERSQQAA 132
Query: 738 QEKDEKL---KTVEELLETGLI--------QVATKEEELNAIRTENSSLTKEVQDLKAKQ 786
Q D L T +++ T L + +E+ N E L EV+ L+AK+
Sbjct: 133 QSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKK 192
Query: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLL 846
Q + + H+ + S ++ L ++ ++ ++ + +
Sbjct: 193 ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
Query: 847 KGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE----VAQHNLKEASSA 902
+ K D +++ L L+ +N+ L+ + E + H +
Sbjct: 253 TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
Query: 903 SQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-N 961
++F+EL++ L++ + EL E +L + +L T + + ++++L + +
Sbjct: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
Query: 962 YQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALA 1021
Q+ ++ L + I E+EKE EL + + + ++ ++ + + ++
Sbjct: 373 CQRQNAESARCSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQECIQMKARLTQELQQAK 429
Query: 1022 STEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKE 1081
+ +LQ +++K + +QQ +E E K+ L + + S + E E+ KE
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLE-EFKQKLCRA-EQAFQASQIKENELRRSMEEMKKE 487
Query: 1082 CMAGTSGSE----EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQE 1137
S SE EV LE +LK + Q E+ K+ E +L+ LQ + Q+
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 1138 EN-----KWKVKVDESHKT--------------IKQMQSSFTSSEQE----LERLRSENK 1174
EN K K+ V + K I+Q+ + +E+E L L + K
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
Query: 1175 DIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQ------NERQKV 1228
+ E L+ E+ + E + +E L++++N T L+T+Q NER +
Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 1229 AGDLHKAQQSLEL------IQSKIVKAAGDTTVI----ENSDVSPETESSEKETMSVSLN 1278
++ + S+E+ + SK V+ + ++ S + E E M + +
Sbjct: 668 L-EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 1279 QTVTQLQQL---LQAVNQQLTKEKEHYQVL 1305
Q Q++ L LQ ++ ++ + YQ L
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Score = 87.0 bits (214), Expect = 1e-16
Identities = 261/1455 (17%), Positives = 570/1455 (39%), Gaps = 277/1455 (19%)
Query: 31 ETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL 90
ETL L +++E +L+ K + ++AE ++ KK N L +S E LS+ L
Sbjct: 901 ETL--SALENKEKELQLLNDKVETEQAEIQELKKS---NHLLEDSLKELQ----LLSETL 951
Query: 91 AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTK 150
++E +++ + S+ +R+ +E Q E +KE +AS + +K+ +
Sbjct: 952 SLEKKEMSSI--------ISLNKREIEELTQ----ENGTLKEINAS-LNQEKMNLIQ--- 995
Query: 151 QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK 210
SE+ A N D+++K + L K+++ + L + +E+G+ +
Sbjct: 996 ----KSESFA-----------NYIDEREKSISELSDQYKQEKLILLQR--CEETGNAYED 1038
Query: 211 ASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK 270
S K + + + + + N +S +++ ++ LK + Q+ TK
Sbjct: 1039 LSQKYKAAQE---------KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
Query: 271 LKTETDKENAEVKFKDFLLSLKTMMF-SEDEALCVVDLLKEKSGVIQDALKKSSKGELTT 329
E +N ++ + +L++ M +++ + LK++ +++ K K E+
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK-EVND 1148
Query: 330 LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE--KERSN----------------- 370
L LQE ++L+ +K TK C+ L E + KER +
Sbjct: 1149 L---LQENEQLMKVMK-----TKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE 1200
Query: 371 VVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA---------EIAH 421
+ + ++ LE + K+ S +E + +Q + Q +R +E EI+
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
Query: 422 LKQ---------------------ENGILRDAVSNTTNQLESKQS-------------AE 447
LK +N L+ ++ T N+L + E
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 448 LN-----------KLRQDYARLVNE---LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEA 493
LN K+ ++ +L+NE L + +G L E V+ + Q Q +
Sbjct: 1321 LNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS 1380
Query: 494 ERRWEEVQSYIRKRTAEHEAAQQ--DLQSKFVAKENEVQSLH-------SKLTDTLVSKQ 544
+E SY ++ E +LQ KF++ ++E + LH SK+++
Sbjct: 1381 LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD 1440
Query: 545 QLEQRLMQLMES---------EQKRVNKEESLQMQVQDILEQNEALKAQI--QQFHSQIA 593
L+ + L + ++ ++ EE L + + + + + F+ +
Sbjct: 1441 SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALL 1500
Query: 594 AQTSASVLAEELHKVIAEKD--------------------------KQIKQTEDSLASER 627
QT L L ++ K +++ E R
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560
Query: 628 DRLTSKEEEL--------KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
L EE++ K+IQ + LL +E Q+L L + + + ++ SV ++
Sbjct: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
+ E++ ++S ++E ++ Q + L + L + +E + + E C
Sbjct: 1621 ESKLAAEKKQTEQLSLELEVARL---QLQGLDLSSRSLLGIDTEDA---IQGRNESCDIS 1674
Query: 740 KDEKLKTVEELLETGLIQVATKEEE----LNAIRTENSSLTKEVQDLKAKQNDQVSF--- 792
K+ +T E + + Q+ K+ + L+ + + K + +Q+ ++
Sbjct: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734
Query: 793 --------ASLVEEL----------------KKVIHEKDGKIKSVEELLEAELLKVANKE 828
+ + EL ++ IH ++K L + +++
Sbjct: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD 1794
Query: 829 KTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 888
+ V+ S+ ++++EL + L +E Q+ T E EK + K DL E+ E
Sbjct: 1795 RKVE-SLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 889 QEVAQHNLKEASSASQFEELEIVLKEKENE-----LKRLEAMLKER----ESDLSSKTQL 939
QE+ Q + +S +LE+ + E + ++ KER E++LS
Sbjct: 1854 QELLQ---RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
Query: 940 LQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 999
++ E ++ +E ++ + +E KVI E+E+S + +E + L+ +
Sbjct: 1911 KASIEHEALYLEADLEVVQTEKLCLEKD---NENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 1000 EHQRKKN---NDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1056
+ KK + L EK E + L S + + E +++ E ++ + +V + L
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
Query: 1057 FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKY 1116
K + L E K + ++ T LE+++ + ++ LL E E
Sbjct: 2028 KDKTHLQEKLQSLE-------KDSQALSLTKCE-----LENQIAQLNKEKELLVKESESL 2075
Query: 1117 KSVLAETEGILQKLQRSVEQ---EENKWKVKVDESHKTIKQMQSSFTSSEQELE------ 1167
++ L+E++ + +++E E+ ++ +++ + + + Q++ +E
Sbjct: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
Query: 1168 -----RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQ 1222
+L+ ++ ++L+ + E+LE EL+ +E + + + KA++ T++
Sbjct: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
Query: 1223 NERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ--- 1279
+ DL + E + +I + G + ++ S ++ EKE + + +
Sbjct: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 1280 -TVTQLQQLLQAVNQ 1293
V LQ L+ +N+
Sbjct: 2256 TAVEMLQNQLKELNE 2270
Score = 58.9 bits (141), Expect = 3e-08
Identities = 98/428 (22%), Positives = 183/428 (42%), Gaps = 69/428 (16%)
Query: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 971
++E E +L +L+ ++R+ L S LQ + + + K++ LK++N
Sbjct: 20 IQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN---------- 69
Query: 972 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD-K 1030
+ L+++ EK + +EL + V Q + N +++ EK+ Q+ K
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQ----------IEKLEQELK 119
Query: 1031 VNKTSKERQQQVEA---VELEAKEVLKKLFPKVSVPSNLSYGEWLHGF-EKKAKECMAGT 1086
K+ ER QQ V L +K+F PS G EK KE
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 1087 SGSEEVKVLEHK-----LKEADEMH----------TLLQLECEKYKSVLAETEGILQKLQ 1131
EVK L+ K L +A H ++ + EK S L+ ++
Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ-RTPIR 238
Query: 1132 RSVEQEENKWKVKVDESHKTI----KQMQSSF---TSSEQELERLRSENKDIENLRRERE 1184
R + +V S T+ + SSF +SS L++L+++N+++ N E
Sbjct: 239 RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINE-- 296
Query: 1185 HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1244
LE+ L+ E E V + +EL+ QL K + E E++KV L+K + L +
Sbjct: 297 -LELRLQGHEKEMKGQVNKFQELQLQLE----KAKVELIEKEKV---LNKCRDELVRTTA 348
Query: 1245 KIVKAAGDTTVIE------NSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKE 1298
+ +A+ T +E D+S + +++ E+ SL Q + + ++ Q ++L+++
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNA--ESARCSLEQKIKEKEKEFQ---EELSRQ 403
Query: 1299 KEHYQVLE 1306
+ +Q L+
Sbjct: 404 QRSFQTLD 411
Score = 37.4 bits (85), Expect = 0.095
Identities = 35/180 (19%), Positives = 82/180 (45%), Gaps = 14/180 (7%)
Query: 1127 LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1186
LQK+Q +E + +K K + + + ++++ +Q++E ++E NL+RE + L
Sbjct: 17 LQKIQE-LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT---NLKRENQRL 72
Query: 1187 EMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI 1246
E E + E++ ++Q+N +L + + + +K+ +L + + LE Q
Sbjct: 73 MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ-- 130
Query: 1247 VKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
+++DVS ++ ++ + L + + + ++ KE E + LE
Sbjct: 131 --------AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 151 bits (382), Expect = 3e-36
Identities = 220/1041 (21%), Positives = 445/1041 (42%), Gaps = 128/1041 (12%)
Query: 342 AAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQET 401
A++K +A+ ++ + ++T R Q + Q
Sbjct: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
Query: 402 QQMQMKFQQVREQMEAEIAH---LKQENGILRDAVSNTTNQLESKQS---AELNKLRQDY 455
+Q+ + R ++ +H ++QE + RD +LE+K + ++
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 456 ARLVNELTEKTGKLQ-------QEEVQKKNAEQAATQLKVQLQEAER----RWEEVQSYI 504
L+N+L E+ K++ +E + K + E A K ++ E E+ R +EV
Sbjct: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
Query: 505 RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKE 564
R+ + A D+ + E+ SL KL T Q+ L + + ++ KE
Sbjct: 485 RRLESNKPAGDVDMSLSLL---QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 565 -ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
++L + + ++NE+LK++++ H+ ++ +L IA + +++ + S
Sbjct: 542 IKALYTATEKLSKENESLKSKLE--HANKENSDVIALWKSKLETAIASHQQAMEELKVSF 599
Query: 624 ASERDRLTSKEEELK-DIQNMNFLLKAEVQKLQALAN-EQAAAAHELE----KMQQSVYV 677
+ T++ ELK I+ M + E++ LQ + E+AA A E+E K+ + +
Sbjct: 600 SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
K++ + + +L + E + ++ + + +V++L+ L ++ + K I
Sbjct: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK------CNEQTKVI 713
Query: 738 QEKDEKLKTVEE-LLETGLIQVATKE--EELNAIRTENSSLTKEVQDLKAKQNDQVSFAS 794
+LK EE LL+ ++ A+ E E+ +R + + K+++ L+ ++N + S AS
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Query: 795 LV------EELKKV-IHEKDGKIKSVEELLEAELLKVANKEKTVQ-----LSITSKVQEL 842
+ ELK + E ++ V+E LE EL + KEK + +S+ +QE
Sbjct: 774 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL--KEKFAEASEEAVSVQRSMQET 831
Query: 843 QNLLKGKEEQMNTMKAVLEEKEKDLANT-GKWLQDLQEENESLKAHVQ---EVAQHNLKE 898
N L KEEQ N + + LE+ ++LA+ K+ + + E + +KA + ++A+
Sbjct: 832 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 891
Query: 899 ASSASQFEELEIVLKEKENELKRLEAML-----------------------------KER 929
++SQ ++ L+ KE +++ L+ L K+
Sbjct: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 951
Query: 930 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP--HEELL----KVISEREK 983
E + + L D++ + + +Q ++LK + Y++A+S HEE+L K + + E
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKAR-YERATSETKTKHEEILQNLQKTLLDTED 1010
Query: 984 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNK-TSKERQQQV 1042
++ G E L +E RK+ + + A +A+ E+M ++K S E +Q
Sbjct: 1011 KLKGAREENSGLLQELEELRKQADKAKAAQ-TAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 1043 EAVELEAKEVLKKLFPKVSVPSNLSY------GEWLHGFEKKAKEC-MAGTSGSEEVKVL 1095
A + LK+ K N S + + F K+ + A S+++ L
Sbjct: 1070 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1129
Query: 1096 -EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES----HK 1150
E +K A+E+ K L E +L +++ E+K+ DE K
Sbjct: 1130 QEENVKLAEELGRSRDEVTSHQK--LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1187
Query: 1151 TIKQMQSSFTSSEQELERLRS-------ENKDIENLRREREHLEMELEKAEMERSTYVTE 1203
+I + T + ELE+LR+ EN ++L + LE + K E++ +
Sbjct: 1188 SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQ 1247
Query: 1204 VRELKAQLNETLTKLRTEQNERQK-----------VAGDLHKAQQSLELIQSKIVKAA-- 1250
++E K QL+ + T+ +E ++ V DL + Q L++ + +AA
Sbjct: 1248 LKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALN 1307
Query: 1251 GDTTVIENSDVSPETESSEKE 1271
G+ + N D + + S+K+
Sbjct: 1308 GNGDDLNNYDSDDQEKQSKKK 1328
Score = 121 bits (304), Expect = 4e-27
Identities = 187/878 (21%), Positives = 391/878 (44%), Gaps = 124/878 (14%)
Query: 247 DKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMM-----FSEDEA 301
+KR+V DL + E I K G ++ T ++K KD L ++ + ++
Sbjct: 434 EKRKVEDLQFRVEEESITK-GDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKP 492
Query: 302 LCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQE 361
VD+ ++Q+ K E+T HQ + + ++KE A ++ ++ +
Sbjct: 493 AGDVDM---SLSLLQEISSLQEKLEVTRTDHQRE-----ITSLKEHFGAREETHQKEIKA 544
Query: 362 MMTEKERSNVVITRMKDRIGTLEKEHN----VFQNKIHVSYQETQQ----MQMKFQQVRE 413
+ T E+ + +K ++ KE++ ++++K+ + QQ +++ F +
Sbjct: 545 LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 604
Query: 414 QMEAEIAHLKQENGILR----DAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKL 469
AE A LK + +R + N NQ +S+++A ++ A+L+ + EK L
Sbjct: 605 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 664
Query: 470 QQEEVQKKNAE-QAATQLKV---QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK 525
+ + AE Q +++ +LQEAE + +E++ ++ + E + S+ A
Sbjct: 665 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE-VLQAKCNEQTKVIDNFTSQLKAT 723
Query: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV-------NKEESLQMQVQDILEQN 578
E ++ L + + K +++ +L Q +E+ +K++ N E S + L+
Sbjct: 724 EEKLLDLDALRKASSEGKSEMK-KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
Query: 579 EALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL 637
E +Q+ S+++ + + + L + AE ++ + S+ ++L KEE+
Sbjct: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
Query: 638 KDIQNMNFLLKAEVQKLQA-LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNK 696
+L ++++KL+ LA+ +A + E+ +Q + K+ + E ++ N
Sbjct: 843 N-------MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNS 895
Query: 697 MEEFKILNDQNKALKSEVQKLQ--------------------TLVSEQPNKDVVEQMEKC 736
+ K +ND+ + + +V++LQ T+ +EQ ++ ++ E+
Sbjct: 896 SQLTK-MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 954
Query: 737 IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796
+E + KL +E+ +ET Q +EL A R E ++ + + + QN Q +
Sbjct: 955 KKELERKLSDLEKKMETSHNQC----QELKA-RYERATSETKTKHEEILQNLQKTLLDTE 1009
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856
++LK E G ++ +EEL K A+K K Q + E+ M M
Sbjct: 1010 DKLKGAREENSGLLQELEELR-----KQADKAKAAQTA---------------EDAMQIM 1049
Query: 857 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKE 916
+ + +EK + LA+ L+D ++ N L+ + + ++NLK ++ +EL V +K
Sbjct: 1050 EQMTKEKTETLAS----LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
Query: 917 NELKRLEAMLKERESDLSSKTQLLQDVQDEN-----KLFKSQIEQLKQQNYQQASSFPPH 971
E ++ LK+ + K+Q L +Q+EN +L +S+ E Q ++ S +
Sbjct: 1106 EEFRKEIETLKQA---AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1162
Query: 972 EEL------LKVISEREKEISGLWNELD------SLKDA-VEHQRKKNNDLREKNWEAME 1018
+ L K I + ++E + L + + KDA +E R + LR +N A
Sbjct: 1163 QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222
Query: 1019 ALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1056
+ + + DKV + + +V+ +EL+ KE ++L
Sbjct: 1223 LHSVVQTLESDKV-----KLELKVKNLELQLKENKRQL 1255
Score = 106 bits (265), Expect = 1e-22
Identities = 156/758 (20%), Positives = 331/758 (43%), Gaps = 110/758 (14%)
Query: 596 TSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE----V 651
T A A + +V+A +K++ AS ++S + + LL
Sbjct: 287 TPAKAKANAVRRVMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH--EISNKMEEFKILNDQNKA 709
+K+ Q A + + ++Q + +D + + + H EI ++ + +DQ+
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 710 -LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK----DEKLKTVEELLETGLIQVATKEEE 764
L++++ +L+T+V E +++ VE + + +EK D + + EE + G ++VAT E+
Sbjct: 405 ELEAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK 463
Query: 765 LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKV 824
+ E L VQ+ V EL++ + + K ++ + L ++
Sbjct: 464 SRIMELEKD-LALRVQE--------------VAELRRRL--ESNKPAGDVDMSLSLLQEI 506
Query: 825 ANKEKTVQLSITSKVQELQNLLKG----KEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 880
++ ++ ++++ T +E+ +L + +E +KA+ EK L +E
Sbjct: 507 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK-----------LSKE 555
Query: 881 NESLKAHVQEVAQHNLKEASSASQF--EELEIVLKEKENELKRLEAML-KERESDLSSKT 937
NESLK+ ++ H KE S +LE + + ++ L+ K ++ +
Sbjct: 556 NESLKSKLE----HANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE-----LLKVISEREKEISGLWNEL 992
+L ++ ++ +IE L+ Q + ++ E L+KVI E+E + + ++L
Sbjct: 612 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671
Query: 993 DSLKDA--VEHQRKKNN----DLREKNWEAMEALASTEKMLQDKVN---KTSKERQQQVE 1043
D +D VE + N +++ K E ++A + + + D K ++E+ ++
Sbjct: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 731
Query: 1044 AVEL---EAKEVLKKLFPKV-SVPSNLSYGEWLHGFEKKAKECMAGTSGSE----EVKV- 1094
A+ E K +KKL ++ + + + E EK A+ A + E E+K+
Sbjct: 732 ALRKASSEGKSEMKKLRQQLEAAEKQIKHLE----IEKNAESSKASSITRELQGRELKLT 787
Query: 1095 -LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1153
L+ L E ++ L+ E + K AE +QRS+++ NK +
Sbjct: 788 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-----------LH 836
Query: 1154 QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNE 1213
Q + F +LE+LR D+E RE++ E +L KA+ + + E+ ++ +
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 1214 TLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS--DVSPETESSEKE 1271
LTK+ E L ++ +E +Q K+ KA + + ++ S D++ + E S++E
Sbjct: 897 QLTKMNDE----------LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE 946
Query: 1272 TM------SVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1303
L + ++ L++ ++ + Q + K Y+
Sbjct: 947 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 150 bits (378), Expect = 1e-35
Identities = 219/1059 (20%), Positives = 445/1059 (42%), Gaps = 115/1059 (10%)
Query: 308 LKEKSGVIQDALKKSS-------------KGELTTLIHQLQEKDKLLAAVKEDAA----- 349
LKE+ +Q AL+KS E LI QLQ + + LA V+E
Sbjct: 864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKS 923
Query: 350 --ATKDRCKQLTQEMMTEKERSNVVITR---MKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
+ R K+L++ + E+E ++ + R ++D L+KE + + + S +E +
Sbjct: 924 KIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTT 983
Query: 405 QMKFQQVREQME---AEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E++E +I+ L + ++++A T + L ++ +L+ L + +L +
Sbjct: 984 EHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEE-KLSSLSKANLKLEQQ 1042
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ E G L+QE + N E+ +L+ L+ E ++S R E + +L
Sbjct: 1043 VDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQM 1102
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ-KRVNKEESLQMQVQDILEQNEA 580
ENE + L ++L T+ Q + L + +E+E+ R E QD+ + NE
Sbjct: 1103 NSKVENE-KGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNER 1161
Query: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER-DRLTSKEEELKD 639
L+ +Q+ ++LH+ + E + T SL D L E ++++
Sbjct: 1162 LEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVEN 1221
Query: 640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
+Q + L+ + LQ ++ ++ + + + +K+ L E+ HE + K+++
Sbjct: 1222 LQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANA----EKLCTLYEERLHEATAKLDK 1277
Query: 700 FKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
V++ N D+ Q K E E L+ +EE
Sbjct: 1278 ---------------------VTQLAN-DLAAQKTKLWSESGEFLRRLEE---------- 1305
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVIHEKDGKIKSVEELLE 818
KE +N + E S+ T++++DL+ + + + S ++L L+K + D + EE E
Sbjct: 1306 -KEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQE 1364
Query: 819 --AELLKVANKEKTVQLSITSK-----VQELQNLLKGKEE-------------QMNTMKA 858
AEL + +K + K +Q ++L K+E N A
Sbjct: 1365 VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNA 1424
Query: 859 VLEEKEKDL-ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 917
LE L G L DL + + Q+ Q A + EE + +L +
Sbjct: 1425 SLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQK 1484
Query: 918 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 977
E++ L L + ++ + ++ ENK + +I L Q + + E++ K+
Sbjct: 1485 EVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKL 1544
Query: 978 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1037
I E + E+ L+ + A+E K + E +EA A E+ L +K +
Sbjct: 1545 IEEEKTEVQ---VTLEETEGALERNESK---ILHFQLELLEAKAELERKLSEKDEEIENF 1598
Query: 1038 RQQQ-------VEAVELEAKEVLKKLFPKVSVPSNLSYGE-WLHGFEKKAKECMAGTSGS 1089
R++Q +++ EAK ++ K + +L+ E L ++ E
Sbjct: 1599 RRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQL 1658
Query: 1090 E-EVKVLEHKLKEADEMHTLL--QLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1146
+ ++K L+ +L ++ ++++ L Q+ + ++ L ++E L+ L+ EQ E ++ +
Sbjct: 1659 QIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSE--LEDLRSLQEQTERGRRLSEE 1716
Query: 1147 ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRE 1206
E + +++ +T + L + + D+ +++E E + E + AE + E
Sbjct: 1717 ELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAAN 1776
Query: 1207 LKAQL---NETLTKL-RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1262
L +L +T+ L RT +N Q + DL K E Q ++ + +E+
Sbjct: 1777 LSEELKKKQDTIAHLERTRENMEQTIT-DLQKRLAEAE--QMALMGSRKQIQKLESRVRE 1833
Query: 1263 PETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEH 1301
E E + S + +L++ ++ + Q ++K++
Sbjct: 1834 LEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKN 1872
Score = 134 bits (336), Expect = 7e-31
Identities = 196/1037 (18%), Positives = 436/1037 (42%), Gaps = 182/1037 (17%)
Query: 308 LKEKSGVIQDALKKSSKGELTT------LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQE 361
LK++ ++ L KS K + TT L +++ ++ ++ + A ++ +Q +
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 362 MMTEKER------SNVVITRMKDRI-GTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQ 414
+ E+E+ +N+ + + D + G LE+E N ++ +++ + + E
Sbjct: 1022 LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESM-EN 1080
Query: 415 MEAEIAHLKQENGILRDAVSNTTNQLESKQS--AELNKLRQDYARLVNELTEKTGKLQQE 472
+E+ HL +E +S +++E+++ A+L K ++ + +L EK L+ E
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEK---LEAE 1137
Query: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQS-------YIRKRTAEHEAAQQDLQSKFVAK 525
+ E+ L L + R EEV +K+ + + +D++ +
Sbjct: 1138 RTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHF 1197
Query: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
E SL + D+L +LE ++ L + +QK + LQ++V D+L + E
Sbjct: 1198 ETTSASLKKRHADSLA---ELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVE------ 1248
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE-------EELK 638
Q ++ A+ ++ E LH+ A+ DK + Q + LA+++ +L S+ EE +
Sbjct: 1249 QMTRAKANAEKLCTLYEERLHEATAKLDK-VTQLANDLAAQKTKLWSESGEFLRRLEEKE 1307
Query: 639 DIQNM------NFLLKAEVQK--LQALANEQAAAAHELEKMQQ----------------- 673
+ N NF + E + L+ Q+A AH L+K Q+
Sbjct: 1308 ALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKA 1367
Query: 674 ----------------------SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALK 711
+V + + + +++L + E + N +N +L+
Sbjct: 1368 ELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLE 1427
Query: 712 --------------SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757
S++ K+++ + K + Q K + + +K + + LL+ +
Sbjct: 1428 RARHQLQLELGDALSDLGKVRSAAARLDQKQL--QSGKALADWKQKHEESQALLDASQKE 1485
Query: 758 VATKEEEL--------------NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803
V EL +R EN +L +E+ +L + + + +E++KK+I
Sbjct: 1486 VQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Query: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK 863
E+ +++ E E L + +K QL + EL+ L K+E++ +
Sbjct: 1546 EEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFR------ 1599
Query: 864 EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 923
+ Q +SL++ + A+ + E+ + K+ E +L +E
Sbjct: 1600 -----------RKQQCTIDSLQSSLDSEAKSRI----------EVTRLKKKMEEDLNEME 1638
Query: 924 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 983
L +S T+ L +Q + K + Q++ Q N +L + ++ E+
Sbjct: 1639 LQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLN----------SDLKEQVAVAER 1688
Query: 984 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAME----------ALASTEKMLQDKVNK 1033
S L +EL+ L+ E + E+ EA E +L S +K L+ V +
Sbjct: 1689 RNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVAR 1748
Query: 1034 TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1093
KE ++ V+ + ++ K ++ L + ++ +E M T +
Sbjct: 1749 MQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQT-----IT 1803
Query: 1094 VLEHKLKEADEMHTL-LQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWKVKVDESHKT 1151
L+ +L EA++M + + + +K +S + E EG L+ +++RS E + +++ +
Sbjct: 1804 DLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLE-----RC 1858
Query: 1152 IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQL 1211
IK++ ++ L R++++ ++ L+ + ++ + ++E AE + + Y+++ ++ + +L
Sbjct: 1859 IKELTYQAEEDKKNLSRMQTQ---MDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHEL 1915
Query: 1212 NETLTKLRTEQNERQKV 1228
NE + +++ K+
Sbjct: 1916 NEVKERAEVAESQVNKL 1932
Score = 103 bits (258), Expect = 8e-22
Identities = 167/798 (20%), Positives = 352/798 (44%), Gaps = 73/798 (9%)
Query: 547 EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL---KAQIQQFHS-----------QI 592
++RL ++ Q R + + ++++ Q ILE+ +AL + I+ F + +I
Sbjct: 790 DERLSKVFTLFQARA-QGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKI 848
Query: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
+S + EE+ + E+ Q+++ + +R+ L +K+ L +N + +L+ + +
Sbjct: 849 KPLVKSSEVGEEVAG-LKEECAQLQKALEKSEFQREELKAKQVSLTQEKN-DLILQLQAE 906
Query: 653 KLQALANEQAAAAHELE-KMQQSVYVKDDKIRLLEEQLQHEISNKME-EFKILNDQNKAL 710
+ + LAN + ++ K+Q VK+ R+ EE+ EI++++ + L D+ L
Sbjct: 907 Q-ETLANVEEQCEWLIKSKIQLEARVKELSERVEEEE---EINSELTARGRKLEDECFEL 962
Query: 711 KSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKL-----------KTVEELLETGLIQV 758
K E+ L+T LV + K E K + E+ E L K V+E + L +
Sbjct: 963 KKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL 1022
Query: 759 ATKEEELNAIRTENSSLTKEVQDLK-AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELL 817
+EE+L+++ N L ++V +L+ A + ++ + + EL H+ +G +K E +
Sbjct: 1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCEREL----HKLEGNLKLNRESM 1078
Query: 818 EAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
E ++ S + L L+ KE +++ M + +E ++ +A K +++L
Sbjct: 1079 E---------------NLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKEL 1123
Query: 878 QEENESLKAHVQEVAQHNLK-EASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 936
Q + + LK ++ K E A ++L + + E A L+ + +
Sbjct: 1124 QTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKF 1183
Query: 937 TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER-EKEISGLWNELDSL 995
+L +D+++ F++ LK+++ + E L+ + ++ EK+ S L E+D L
Sbjct: 1184 QKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDL 1243
Query: 996 KDAVEHQ-RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLK 1054
VE R K N EK E DKV + + + Q + E+ E L+
Sbjct: 1244 LTRVEQMTRAKAN--AEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLR 1301
Query: 1055 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAG-TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113
+L K ++ + LS + F ++ ++ ++ L H L++A LL+ +
Sbjct: 1302 RLEEKEALINQLSREK--SNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQY 1359
Query: 1114 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE-LERLRSE 1172
E+ + V AE L K+ + Q K++ V + + ++ + QE E +
Sbjct: 1360 EEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVA 1419
Query: 1173 NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDL 1232
N +L R R L++EL A + + L + ++ L + + ++ L
Sbjct: 1420 NARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALL 1479
Query: 1233 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQ------ 1286
+Q+ ++ + ++++K E S V ET E + + ++ Q+++
Sbjct: 1480 DASQKEVQALSTELLKL---KNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLT 1536
Query: 1287 LLQAVNQQLTKEKEHYQV 1304
++ V + + +EK QV
Sbjct: 1537 EMEKVKKLIEEEKTEVQV 1554
Score = 100 bits (249), Expect = 9e-21
Identities = 158/800 (19%), Positives = 325/800 (40%), Gaps = 105/800 (13%)
Query: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Q+E +K TK K D E A + F+ SLK ++L ++ E ++
Sbjct: 1172 QLEITKKQETKFQKLHRDMEEATLHFETTSASLKK---RHADSLAELEGQVENLQQVKQK 1228
Query: 319 LKKSSK------GELTTLIHQL----QEKDKLLAAVKE---DAAATKDRCKQLTQEMMTE 365
L+K +L T + Q+ +KL +E +A A D+ QL ++ +
Sbjct: 1229 LEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288
Query: 366 KERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAE------I 419
K T++ G + + I+ +E + + +R Q+E E +
Sbjct: 1289 K-------TKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSAL 1341
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK-KN 478
AH Q+ RD Q E +Q + +L + +++ E+ + K + +Q+ ++
Sbjct: 1342 AHALQK--AQRDC-DLLREQYEEEQEVKA-ELHRTLSKVNAEMVQWRMKYENNVIQRTED 1397
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF---VAKENEVQSLHSK 535
E A +L ++LQEA E R A E A+ LQ + ++ +V+S ++
Sbjct: 1398 LEDAKKELAIRLQEA----AEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAAR 1453
Query: 536 LTD-------TLVSKQQLEQRLMQLMESEQKRVNK------------EESLQMQVQDILE 576
L L +Q + L+++ QK V EES+ Q + +
Sbjct: 1454 LDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQ-ETLRR 1512
Query: 577 QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK--- 633
+N+ L+ +I +Q+ T E++ K+I E+ +++ T + +R SK
Sbjct: 1513 ENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILH 1572
Query: 634 ----------------EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E+ ++I+N + + LQ+ + +A + E+ ++++ +
Sbjct: 1573 FQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEE 1632
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-QPNKDVVEQMEKC 736
+++ L ++S + L Q K L+ ++ L S+ + V E+
Sbjct: 1633 DLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSL 1692
Query: 737 IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV 796
+Q + E L++++E E G + ++EE L A N T+ L K+ + A +
Sbjct: 1693 LQSELEDLRSLQEQTERG--RRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQ 1750
Query: 797 EELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTM 856
+E ++V+ E ++ EE + ++ AN + + K + +L + +E T+
Sbjct: 1751 KEAEEVVQE----CQNAEEKAKKAAIEAANLSE----ELKKKQDTIAHLERTRENMEQTI 1802
Query: 857 ----KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVL 912
K + E ++ L + K +Q L+ L+ ++ + + + A + E
Sbjct: 1803 TDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERC---- 1858
Query: 913 KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE 972
+K L +E + +LS + +Q + + +K Q+E + Q Q S + +
Sbjct: 1859 ------IKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQ 1912
Query: 973 ELLKVISEREKEISGLWNEL 992
L + ER + N+L
Sbjct: 1913 HELNEVKERAEVAESQVNKL 1932
Score = 63.2 bits (152), Expect = 2e-09
Identities = 105/467 (22%), Positives = 187/467 (40%), Gaps = 83/467 (17%)
Query: 915 KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN------------Y 962
K L +LEA+ ER SK L + + KL + + +++ ++ +
Sbjct: 778 KAGFLGQLEAIRDER----LSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAF 833
Query: 963 QQASSFPPHEELLKV-----ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAM 1017
++P K+ SE +E++GL E L+ A+E + +L+ K
Sbjct: 834 MAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLT 893
Query: 1018 EALASTEKMLQDKVNKTSKERQQQVE-----AVELEA--KEVLKKLFPKVSVPSNLSY-G 1069
+ LQ + +T ++Q E ++LEA KE+ +++ + + S L+ G
Sbjct: 894 QEKNDLILQLQAE-QETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARG 952
Query: 1070 EWLHG--FEKKAK----ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1123
L FE K + E M S E+ + EHK+K E L + K
Sbjct: 953 RKLEDECFELKKEIDDLETMLVKSEKEK-RTTEHKVKNLTEEVEFLNEDISKLNRAAKVV 1011
Query: 1124 EGILQKLQRSVEQEEN----------KWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1173
+ Q+ + EE K + +VDE ++Q + + + E+EL +L
Sbjct: 1012 QEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNL 1071
Query: 1174 K----DIENLRREREHLEMELEKAEMERSTYVTE--------------VRELKAQLNETL 1215
K +ENL + HL EL K E+E S ++ V+EL+ Q+ +
Sbjct: 1072 KLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLK 1131
Query: 1216 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDT-----------TVIENSDVSPE 1264
KL E+ R K+ + Q L + ++ + G + T + E
Sbjct: 1132 EKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDME 1191
Query: 1265 TESSEKETMSVSLNQ----TVTQLQ---QLLQAVNQQLTKEKEHYQV 1304
+ ET S SL + ++ +L+ + LQ V Q+L K+K Q+
Sbjct: 1192 EATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQL 1238
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 148 bits (374), Expect = 3e-35
Identities = 235/1176 (19%), Positives = 509/1176 (43%), Gaps = 188/1176 (15%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E Q++ K+ +K+++ E V L+ + L
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT--LVQEKNDLQLQVQ 893
Query: 240 ADSSPVVDKREVID-LLKPD-QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+S ++D E D L+K Q+E K T++ + E ++ NAE+ K +D LK
Sbjct: 894 AESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLEDECSELK 952
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L +L D+ +A + + A +
Sbjct: 953 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEELSGLDETIAKLTREKKALQ 1001
Query: 353 DRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH---VSYQETQQMQMKFQ 409
+ +Q ++ E+ D++ +L K + + ++ S ++ +++++ +
Sbjct: 1002 EAHQQALDDLQAEE-----------DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050
Query: 410 QVREQMEAEIAHLKQENGILRDAVSNTTNQLESK--QSAELNKLRQDYARLVNELTEKTG 467
+ + ++E ++ ++ L + +L+ K + +L +D L + +K
Sbjct: 1051 RNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110
Query: 468 KLQ------QEEVQKKNAEQAATQLKV-----QLQEAERRWEEVQSYI-------RKRTA 509
+LQ +EE++ + A +A T+ + +L+E R EE +KR A
Sbjct: 1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREA 1170
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
E ++DL+ + E V +L K D++ +L +++ L +QK ++ ++
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEFKL 1227
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
++ D+ S E + K A +K + ED L+ R +
Sbjct: 1228 EIDDL------------------------SSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI-RLLEEQ 688
+ L ++ L+ E +L E+ + +L + +Q+ + +++ R LEE+
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE 1323
Query: 689 ------LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742
L H + + + +L +Q + + +LQ +S+ N +V + K + +
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA-NSEVAQWRTKYETDAIQ 1382
Query: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTK-------EVQDLKAKQNDQVSFASL 795
+ + +EE + ++ EE++ A+ + +SL K EV+DL S A+
Sbjct: 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 796 VEELK----KVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEE 851
+++ + KV+ E K + + LEA L KE S+++++ +L+N + +
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASL-----KESR---SLSTELFKLKNAYEEALD 1494
Query: 852 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 911
Q+ T+K + E+++A+ + + E +++ + Q L++A EE E
Sbjct: 1495 QLETVKRENKNLEQEIADL---TEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551
Query: 912 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 971
L+ +E ++ R++ L + +S++ K +DE +IEQLK+ NYQ+
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIA----EKDE------EIEQLKR-NYQRTVETMQS 1600
Query: 972 EELLKVISERE-----KEISGLWNELD--------SLKDAVEHQRKKNNDLREKNWEAME 1018
+V S E K++ G NE++ + ++H R L++ +
Sbjct: 1601 ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD 1660
Query: 1019 ALASTEKMLQDK--VNKTSKERQQQVEAVE--LEAKEVLKKLFPKVSVPSN-------LS 1067
AL E + + V + + Q +VE + LE E +KL + + SN
Sbjct: 1661 ALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ 1720
Query: 1068 YGEWLHGFEKKAKECMAGTS----GSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1123
+H +K + M S S + + E K K+A ++ E +K + +T
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ----DT 1776
Query: 1124 EGILQKLQRSVEQEENKWKVKVDESH--------KTIKQMQSSFTSSEQELERLRSENKD 1175
L+++++++EQ + ++DE+ K I+++++ E ELE + +N +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836
Query: 1176 -IENLRR-EREHLEME----------------LEKAEMERSTYVTEVRELKAQLNETLTK 1217
++ LR+ ER E+ ++K +++ +Y + E Q N LTK
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896
Query: 1218 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDT 1253
R Q+E L +A++ ++ +S++ K T
Sbjct: 1897 FRKAQHE-------LEEAEERADIAESQVNKLRAKT 1925
Score = 80.1 bits (196), Expect = 1e-14
Identities = 112/533 (21%), Positives = 229/533 (42%), Gaps = 61/533 (11%)
Query: 778 EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITS 837
+++ L + A++ EE +K E K ++ + LE +L+ + ++ +QL + +
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKLVTLVQEKNDLQLQVQA 894
Query: 838 KVQELQNLLKGKE--EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 895
E +NLL +E +Q+ K LE K K++ + +++ E + K +++
Sbjct: 895 ---ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Query: 896 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 955
K+ ++LE+ L + E E E +K +LS + + + E K
Sbjct: 952 KKD------IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL----- 1000
Query: 956 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWE 1015
Q+ +QQA EE ++ K S L +++ L+ ++E ++K DL E+N
Sbjct: 1001 ---QEAHQQALDDLQAEE--DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL-ERNKR 1054
Query: 1016 AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH-G 1074
+E K+ Q+ + ++QQ E ++ KK F + S + + L
Sbjct: 1055 KLEG---DLKLAQESILDLENDKQQLDERLK-------KKDFEYCQLQSKVEDEQTLGLQ 1104
Query: 1075 FEKKAKECMAGTSGSEEVKVLEHKLK-EADEMHTLLQLECEKYKSVLAETEGILQ-KLQR 1132
F+KK KE A EE E + + ++ + E E+ L E G+ +++
Sbjct: 1105 FQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 1133 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR-----EREHLE 1187
+ ++E K++ D T++ ++ + + + I+NL+R E+E E
Sbjct: 1165 NKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1224
Query: 1188 MELE--------------KAEMER-----STYVTEVRELKAQLNETLTKLRTEQNERQKV 1228
+LE KA +E+ ++E R ++ +L++L T+++ Q
Sbjct: 1225 FKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284
Query: 1229 AGDLHKAQQSLELIQSKIVKA-AGDTTVIENSDVSPETESSEKETMSVSLNQT 1280
AG+L + + E I S++ ++ T E E E+ K ++ +L +
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS 1337
Score = 47.8 bits (112), Expect = 7e-05
Identities = 53/220 (24%), Positives = 105/220 (47%), Gaps = 46/220 (20%)
Query: 1090 EEVKVLEHKLKEADE-MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK---- 1144
+E+ E K KE +E + TL+Q + + V AE+E +L +R + + K++++
Sbjct: 862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIK 921
Query: 1145 -VDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTE 1203
V E + +++ + T+ +++LE SE L+++ + LE+ L K E E+ +
Sbjct: 922 EVTERAEDEEEINAELTAKKRKLEDECSE------LKKDIDDLELTLAKVEKEKHATENK 975
Query: 1204 VRELKAQLN---ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD 1260
V+ L +L+ ET+ KL E+ Q+ QQ+L+ +Q++
Sbjct: 976 VKNLTEELSGLDETIAKLTREKKALQEAH------QQALDDLQAE--------------- 1014
Query: 1261 VSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1300
E SLN+T ++L+Q ++ + L +EK+
Sbjct: 1015 ----------EDKVNSLNKTKSKLEQQVEDLESSLEQEKK 1044
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.309
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,646,004
Number of Sequences: 37866
Number of extensions: 1999161
Number of successful extensions: 34715
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 1684
Number of HSP's that attempted gapping in prelim test: 10991
Number of HSP's gapped (non-prelim): 10839
length of query: 1306
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1192
effective length of database: 13,930,794
effective search space: 16605506448
effective search space used: 16605506448
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.