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Search of human proteins with 117956403
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117956403 rabaptin, RAB GTPase binding effector protein 2
[Homo sapiens]
(569 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Ho... 1082 0.0
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 214 1e-55
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 199 4e-51
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 84 3e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 84 3e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 84 3e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 84 3e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 84 3e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 84 3e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 84 3e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 84 3e-16
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 78 2e-14
gi|16262452 cingulin [Homo sapiens] 77 4e-14
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 77 6e-14
gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1 [... 76 7e-14
gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2 [... 76 7e-14
gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3 [... 76 7e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 76 9e-14
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 75 1e-13
gi|21735548 centrosomal protein 2 [Homo sapiens] 75 2e-13
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 74 5e-13
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 71 2e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 71 2e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 71 2e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 71 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 71 2e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 69 9e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 69 9e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 69 9e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 69 1e-11
>gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Homo
sapiens]
Length = 569
Score = 1082 bits (2799), Expect = 0.0
Identities = 569/569 (100%), Positives = 569/569 (100%)
Query: 1 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV 60
MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV
Sbjct: 1 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV 60
Query: 61 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER 120
AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER
Sbjct: 61 AEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKER 120
Query: 121 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 180
ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI
Sbjct: 121 ELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 180
Query: 181 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 240
QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG
Sbjct: 181 QRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 240
Query: 241 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 300
GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR
Sbjct: 241 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 300
Query: 301 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ 360
QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ
Sbjct: 301 QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ 360
Query: 361 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL 420
LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL
Sbjct: 361 LQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQL 420
Query: 421 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS 480
LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS
Sbjct: 421 LCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEAS 480
Query: 481 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE 540
LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE
Sbjct: 481 LCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLE 540
Query: 541 RIRQAETLEQVRSIMDEAPLTDVRDIKDT 569
RIRQAETLEQVRSIMDEAPLTDVRDIKDT
Sbjct: 541 RIRQAETLEQVRSIMDEAPLTDVRDIKDT 569
>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
isoform 2 [Homo sapiens]
Length = 829
Score = 214 bits (546), Expect = 1e-55
Identities = 188/701 (26%), Positives = 316/701 (45%), Gaps = 160/701 (22%)
Query: 22 LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81
LE R+Q E+ E++ LR L+ E + + E AE + +V ++
Sbjct: 136 LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED--AEKLRSVVMPMEK 193
Query: 82 EVASLQAIL---KDSISSYEAQ----------------------ITALKQERQQQQQDCE 116
E+A+L+ L +D I EA + L ++ Q+D E
Sbjct: 194 EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
Query: 117 EKERELGRLKQLLSRAYPL-DSLEKQMEKAHE---DSEKL-------REIVLPME--KEI 163
+ +EL + LL + + L+ +KA++ +S++L EIVL E +++
Sbjct: 254 KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQV 313
Query: 164 EELKAK-------------------------------LLRAEELIQEIQRRPRHAPSLHG 192
EELK K L EE ++ H S G
Sbjct: 314 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG 373
Query: 193 STE------LLP-----------LSRDPSPPLEPLEELSGDGGPAAEAFAHNCD------ 229
S LLP + +D + + L G ++A +N
Sbjct: 374 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN 433
Query: 230 -------------------DSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
D+AS+ S + G + ++ + ++PEQEETASL+S+
Sbjct: 434 LDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV 493
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEG------------------------------- 299
T E Y+ P GY+LV +T+W LQ E
Sbjct: 494 TQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET 553
Query: 300 -----------RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTL 348
RQ LE +++ EL++ +++S+ED + Q+ L+ + Q SE LL L
Sbjct: 554 RDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEEL 613
Query: 349 QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408
Q +SQA+ VQ QMA L+ + + + E+ RL ++N L+ + + Q Q E+
Sbjct: 614 QQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAEDF 668
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
LP + L++L+ R++ A +H E+L+ EI+ L+E ++ E + +LE L+
Sbjct: 669 ILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ 728
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528
++ E + AS+ SL+ E+ER++ E+ +A + L+ E++ K RLQ EL+ SEQVQRDF
Sbjct: 729 LEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDF 788
Query: 529 VRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT 569
V+LSQ LQV+LERIRQA++LE++R+I+++ LTD+ + +T
Sbjct: 789 VKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 829
Score = 137 bits (344), Expect = 3e-32
Identities = 77/162 (47%), Positives = 109/162 (67%), Gaps = 1/162 (0%)
Query: 21 ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
A E+ ++ A +A +L LR +L A AEME +KA+A VSE+TK EA+ V+RQ +
Sbjct: 52 AKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWR 111
Query: 81 EEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLE 139
EEVASLQA++K+++ YE Q L+QER Q Q E ERE+ L++ LS ++LE
Sbjct: 112 EEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLE 171
Query: 140 KQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
+M+KA ED+EKLR +V+PMEKEI LK KL AE+ I+E++
Sbjct: 172 NEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE 213
Score = 40.0 bits (92), Expect = 0.006
Identities = 67/315 (21%), Positives = 120/315 (38%), Gaps = 61/315 (19%)
Query: 293 EQLQTEGRQLQKDLE-SVSRERDELQEGLRRSNEDCAKQMQVL----------------- 334
E++ E + Q+ LE +++R + +E ED +Q VL
Sbjct: 22 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
Query: 335 LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQ--- 391
A+++N + + + T +A + V+ Q E V + + + E R E LR EQ
Sbjct: 82 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
Query: 392 ---------------LPSSAPQGSQQE---------QGEEESLPSSVPELQQLLCCTRQE 427
L +G ++E Q + E L S V +++ + + +
Sbjct: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
Query: 428 ARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTE 487
+A++ E ++ L LE E R LE + V + VL+ LR E
Sbjct: 202 L---TEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE 258
Query: 488 MERV-----QQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERI 542
+ V Q+ Q QL + + LE+ + RD R+ + + E++
Sbjct: 259 LHEVCHLLEQERQQHNQLKHTWQKANDQF------LESQRLLMRDMQRME--IVLTSEQL 310
Query: 543 RQAETLEQVRSIMDE 557
RQ E L++ DE
Sbjct: 311 RQVEELKKKDQEDDE 325
>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
1 [Homo sapiens]
Length = 862
Score = 199 bits (507), Expect = 4e-51
Identities = 189/734 (25%), Positives = 317/734 (43%), Gaps = 193/734 (26%)
Query: 22 LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81
LE R+Q E+ E++ LR L+ E + + E AE + +V ++
Sbjct: 136 LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED--AEKLRSVVMPMEK 193
Query: 82 EVASLQAIL---KDSISSYEAQ----------------------ITALKQERQQQQQDCE 116
E+A+L+ L +D I EA + L ++ Q+D E
Sbjct: 194 EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
Query: 117 EKERELGRLKQLLSRAYPL-DSLEKQMEKAHE---DSEKL-------REIVLPME--KEI 163
+ +EL + LL + + L+ +KA++ +S++L EIVL E +++
Sbjct: 254 KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQV 313
Query: 164 EELKAK-------------------------------LLRAEELIQEIQRRPRHAPSLHG 192
EELK K L EE ++ H S G
Sbjct: 314 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG 373
Query: 193 STE------LLP-----------LSRDPSPPLEPLEELSGDGGPAAEAFAHNCD------ 229
S LLP + +D + + L G ++A +N
Sbjct: 374 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN 433
Query: 230 -------------------DSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
D+AS+ S + G + ++ + ++PEQEETASL+S+
Sbjct: 434 LDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV 493
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEG------------------------------- 299
T E Y+ P GY+LV +T+W LQ E
Sbjct: 494 TQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET 553
Query: 300 -----------RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTL 348
RQ LE +++ EL++ +++S+ED + Q+ L+ + Q SE LL L
Sbjct: 554 RDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEEL 613
Query: 349 QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408
Q +SQA+ VQ QMA L+ + + + E+ RL ++N L+ + + Q Q E+
Sbjct: 614 QQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAEDF 668
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
LP + L++L+ R++ A +H E+L+ EI+ L+E ++ E + +LE L+
Sbjct: 669 ILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ 728
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQ--------------------------------- 495
++ E + AS+ SL+ E+ER++ E+
Sbjct: 729 LEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETA 788
Query: 496 SKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIM 555
+KA + L+ E++ K RLQ EL+ SEQVQRDFV+LSQ LQV+LERIRQA++LE++R+I+
Sbjct: 789 AKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAIL 848
Query: 556 DEAPLTDVRDIKDT 569
++ LTD+ + +T
Sbjct: 849 NDTKLTDINQLPET 862
Score = 137 bits (344), Expect = 3e-32
Identities = 77/162 (47%), Positives = 109/162 (67%), Gaps = 1/162 (0%)
Query: 21 ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
A E+ ++ A +A +L LR +L A AEME +KA+A VSE+TK EA+ V+RQ +
Sbjct: 52 AKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWR 111
Query: 81 EEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLE 139
EEVASLQA++K+++ YE Q L+QER Q Q E ERE+ L++ LS ++LE
Sbjct: 112 EEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLE 171
Query: 140 KQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
+M+KA ED+EKLR +V+PMEKEI LK KL AE+ I+E++
Sbjct: 172 NEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE 213
Score = 40.0 bits (92), Expect = 0.006
Identities = 67/315 (21%), Positives = 120/315 (38%), Gaps = 61/315 (19%)
Query: 293 EQLQTEGRQLQKDLE-SVSRERDELQEGLRRSNEDCAKQMQVL----------------- 334
E++ E + Q+ LE +++R + +E ED +Q VL
Sbjct: 22 EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
Query: 335 LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQ--- 391
A+++N + + + T +A + V+ Q E V + + + E R E LR EQ
Sbjct: 82 QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
Query: 392 ---------------LPSSAPQGSQQE---------QGEEESLPSSVPELQQLLCCTRQE 427
L +G ++E Q + E L S V +++ + + +
Sbjct: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
Query: 428 ARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTE 487
+A++ E ++ L LE E R LE + V + VL+ LR E
Sbjct: 202 L---TEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE 258
Query: 488 MERV-----QQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERI 542
+ V Q+ Q QL + + LE+ + RD R+ + + E++
Sbjct: 259 LHEVCHLLEQERQQHNQLKHTWQKANDQF------LESQRLLMRDMQRME--IVLTSEQL 310
Query: 543 RQAETLEQVRSIMDE 557
RQ E L++ DE
Sbjct: 311 RQVEELKKKDQEDDE 325
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1903 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2069
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2123
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2124 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2179 RQKAQV--EQELTTLR 2192
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1928
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2107 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2142
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2143 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2191
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2248
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2249 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2305
Query: 553 SIMDE 557
++ ++
Sbjct: 2306 ALAEK 2310
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2259
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2313
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2548 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2597
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2598 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2634
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1468 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1574
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1575 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1658
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1659 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1712
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1769 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1346 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1523
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1524 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1562
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1563 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1603
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1657
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1713
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1714 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1761
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1068 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1126
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1187 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1238
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1239 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1295
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1296 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1341
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1342 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1394
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1395 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1431
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1492 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1547 EAERRLRQAE-VERARQV 1563
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2341
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2456
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2517 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2553
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2610
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2611 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVR 2689
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1123
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1124 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1243 AVREQLRQEQALLEEIER 1260
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1907 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2073
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2127
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2128 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2183 RQKAQV--EQELTTLR 2196
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1932
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2052
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2111 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2146
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2147 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2195
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2252
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2253 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2309
Query: 553 SIMDE 557
++ ++
Sbjct: 2310 ALAEK 2314
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2263
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2317
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2496 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2552 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2601
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2602 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2638
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1472 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1578
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1579 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1623
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1624 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1662
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1663 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1716
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1717 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1773 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1350 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1527
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1528 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1566
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1567 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1607
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1661
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1717
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1718 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1765
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1072 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1130
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1131 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1191 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1242
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1243 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1299
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1300 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1345
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1346 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1398
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1399 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1435
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1496 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1551 EAERRLRQAE-VERARQV 1567
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2345
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2405
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2406 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2460
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2521 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2557
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2558 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2614
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2615 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2670 AEELQRLAQGHTTVDELARREDVR 2693
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1127
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1128 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1247 AVREQLRQEQALLEEIER 1264
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1903 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2069
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2123
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2124 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2179 RQKAQV--EQELTTLR 2192
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1928
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2048
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2107 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2142
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2143 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2191
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2248
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2249 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2305
Query: 553 SIMDE 557
++ ++
Sbjct: 2306 ALAEK 2310
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2259
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2313
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2548 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2597
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2598 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2634
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1468 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1574
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1575 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1658
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1659 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1712
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1713 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1769 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1346 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1523
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1524 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1562
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1563 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1603
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1657
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1713
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1714 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1761
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1068 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1126
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1187 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1238
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1239 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1295
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1296 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1341
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1342 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1394
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1395 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1431
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1492 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1547 EAERRLRQAE-VERARQV 1563
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2341
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2456
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2517 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2553
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2610
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2611 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVR 2689
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1123
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1124 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1243 AVREQLRQEQALLEEIER 1260
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1871 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2037
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2091
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2092 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2147 RQKAQV--EQELTTLR 2160
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1896
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2016
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2075 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2110
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2111 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2159
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2216
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2217 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2273
Query: 553 SIMDE 557
++ ++
Sbjct: 2274 ALAEK 2278
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2170
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2227
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2281
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2460 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2516 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2565
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2566 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2602
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1436 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1487
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1542
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1543 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1587
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1588 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1626
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1627 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1680
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1681 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1736
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1737 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1314 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1491
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1492 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1530
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1531 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1571
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1625
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1626 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1681
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1682 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1729
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1036 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1094
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1095 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1155 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1206
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1207 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1263
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1264 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1309
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1310 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1362
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1363 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1399
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1460 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1515 EAERRLRQAE-VERARQV 1531
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2309
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2369
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2370 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2424
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2485 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2521
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2522 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2578
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2579 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2634 AEELQRLAQGHTTVDELARREDVR 2657
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1091
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1092 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1211 AVREQLRQEQALLEEIER 1228
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 2040 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2206
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2260
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2261 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2316 RQKAQV--EQELTTLR 2329
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 2065
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2185
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2244 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2279
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2280 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2328
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2385
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2386 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2442
Query: 553 SIMDE 557
++ ++
Sbjct: 2443 ALAEK 2447
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2396
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2450
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2629 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2685 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2734
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2735 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2771
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1605 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1656
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1711
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1712 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1756
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1757 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1795
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1796 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1849
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1850 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1905
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1906 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1483 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1660
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1661 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1699
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1700 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1740
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1794
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1850
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1851 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1898
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1205 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1263
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1264 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1324 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1375
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1376 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1432
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1433 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1478
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1479 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1531
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1532 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1568
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1629 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1684 EAERRLRQAE-VERARQV 1700
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2478
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2539 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2593
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2654 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2690
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2691 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2747
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2748 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2803 AEELQRLAQGHTTVDELARREDVR 2826
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1261 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1380 AVREQLRQEQALLEEIER 1397
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1881 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2047
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2101
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2102 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2157 RQKAQV--EQELTTLR 2170
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1906
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1967 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2026
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2085 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2120
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2121 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2169
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2226
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2227 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2283
Query: 553 SIMDE 557
++ ++
Sbjct: 2284 ALAEK 2288
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2180
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2237
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2291
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2470 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2526 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2575
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2576 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2612
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1446 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1497
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1498 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1552
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1553 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1597
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1598 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1636
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1637 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1690
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1691 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1746
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1747 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1803
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1324 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1501
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1502 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1540
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1541 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1581
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1635
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1691
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1692 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1739
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1046 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1104
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1105 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1165 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1216
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1217 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1273
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1274 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1319
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1320 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1372
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1373 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1409
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1470 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1525 EAERRLRQAE-VERARQV 1541
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2319
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2380 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2434
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2495 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2531
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2532 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2588
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2589 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2643
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2644 AEELQRLAQGHTTVDELARREDVR 2667
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1101
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1102 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1221 AVREQLRQEQALLEEIER 1238
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1889 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2055
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2109
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2110 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2165 RQKAQV--EQELTTLR 2178
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1914
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 1975 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2034
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2093 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2128
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2129 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2177
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2234
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2235 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2291
Query: 553 SIMDE 557
++ ++
Sbjct: 2292 ALAEK 2296
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2188
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2245
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2299
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2478 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2534 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2583
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2584 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2620
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1454 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1505
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1506 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1560
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1561 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1605
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1606 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1644
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1645 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1698
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1699 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1754
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1755 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1811
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1332 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1509
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1510 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1548
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1549 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1589
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1643
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1644 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1699
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1700 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1747
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1054 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1112
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1113 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1173 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1224
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1225 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1281
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1282 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1327
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1328 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1380
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1381 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1417
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1478 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1533 EAERRLRQAE-VERARQV 1549
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2327
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2387
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2388 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2442
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2503 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2539
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2540 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2596
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2597 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2651
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2652 AEELQRLAQGHTTVDELARREDVR 2675
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1109
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1110 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1229 AVREQLRQEQALLEEIER 1246
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 84.3 bits (207), Expect = 3e-16
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 84/616 (13%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELS-------RLRAE-------LAGALA 52
VA +E RR E R++E A E E +L RL+AE LA A A
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Query: 53 EMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSY----EAQITALKQER 108
E + +A E KAE A QR+ E+ Q L + + E ++ L+ E
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749
Query: 109 QQQQQDCEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKL--------REIVLPM 159
+Q +Q + E EL RL++ + A LE ++ K + E L E
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809
Query: 160 EKEIEELKAKLLRAEELIQEIQR---------RPRHAPSLHGSTELLPLSRDPSPPLEPL 210
EK + L+A+ R EL +E R R R + + R + L +
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E + A A ++ + + Q+ Q + +E A L
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Query: 271 TLVPEGIYLPPPGYQLVPDT--QWEQLQTEGRQLQKDLESVSRERDELQEGL---RRSNE 325
E LV DT Q Q++ E L+ E + + EL+ L R + E
Sbjct: 1930 DSELER------QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983
Query: 326 DCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA-------------ELVTTHKC 372
D + + + QL + +A+ERVQ +A E V K
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043
Query: 373 LHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARL 432
E +RL E + A QL + ++ Q EE++ +V + + QE + L
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTL 2096
Query: 433 QAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQ 492
Q ++ ++LR E R A EE AR E + R + E E R + +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE------RLKQSAEE 2150
Query: 493 QEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD--FVRLSQALQVRLERIRQ--AETL 548
Q Q++AQ ++ A+ LR +AE E + + Q + +R QA +E+ ++ +TL
Sbjct: 2151 QAQARAQ-----AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 549 EQVRSIMDEAPLTDVR 564
Q + E LT +R
Sbjct: 2206 RQKAQV--EQELTTLR 2219
Score = 70.9 bits (172), Expect = 3e-12
Identities = 150/605 (24%), Positives = 243/605 (40%), Gaps = 98/605 (16%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQEGANG---EAESGELSRLRAELAGALAEMETMK 58
A A V A+ + A E+SRS + EAE+G L E A A E K
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 59 AVAEVSESTKAEAVAAVQRQCQEEVAS------LQAILKDSISSYEAQITALK------- 105
+++E A A +R E++A+ L+ + ++ EA+ L+
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 106 -QERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE 164
Q R+ ++Q + K RL QL R LE+Q + + R++ E+EI
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDTLRQRRQV----EEEIL 1955
Query: 165 ELKAKLLRAE----ELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGP- 219
LKA +A EL E+ R +A S E L L EE
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
Query: 220 ------AAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
AAE A +A L V + L + + S Q + A + L
Sbjct: 2016 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ 2075
Query: 274 PE----GIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAK 329
E + +L Q EQ + QL+ + E+ R +E +E ++ + A+
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 330 QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+ QV+ +E+L ++ + QAQ R Q Q A ++L +E A
Sbjct: 2134 SRR----QVEEAERLKQSAE---EQAQARAQAQAA------------AEKLRKE-----A 2169
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
EQ A + +Q EQ ++ E+++ Q R + Q ++ E+ TL
Sbjct: 2170 EQ---EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ--------ELTTL 2218
Query: 450 REALEEETVARASLEGQL-RVQREETEV------LEASLCSLRTEMERVQQEQSKAQLPD 502
R LEE + L+ +L R++ E TE +E L S+R +ME + + +++ +
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE--- 2275
Query: 503 LLSEQRAKVLR--------LQAELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVR 552
+E RA +LR LQ E E +QV + RLS A Q R+RQ E L Q R
Sbjct: 2276 --AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQR 2332
Query: 553 SIMDE 557
++ ++
Sbjct: 2333 ALAEK 2337
Score = 67.0 bits (162), Expect = 4e-11
Identities = 125/579 (21%), Positives = 240/579 (41%), Gaps = 51/579 (8%)
Query: 2 AAAAPVAADDDERRRRPGA--ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKA 59
A AA AA++ E R A + R E A +S E A A AE +A
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169
Query: 60 VAEVSESTKAEAVAAVQRQCQE-EVASLQAILKDSI---SSYEAQITALKQERQQQQQDC 115
E + +AE A Q+Q + E+ + + ++ + E ++T L+ + ++
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2229
Query: 116 EEKERELGRLK-QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
+ EL RLK + A +E+++ E+L ++ +E E +A +LR +
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE---AENRALILRDK 2286
Query: 175 ELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPL--EELSGDGGPAAEAFAHNCDDS 231
+ Q +Q + L ++ + L L E+L+ A +
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML------K 2340
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
+ + + + + L Q ++ L+ QE+ L + + + G+Q + +
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 292 WE---QLQTEGRQLQKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++ E +L+ + +SR + +E R+ E+ +++ Q L+
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458
Query: 346 RTLQGTVSQAQ---ERVQLQMAELVTTHKCLHHEVKRL---NEENQGLRAEQLPSSAPQG 399
+TL+ Q+ ER++ +AEL + L E K L +EE Q ++ EQL
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
Q E++SL ++Q + + Q + A++LR E ++ +E+E
Sbjct: 2519 QQSFLSEKDSLLQRERFIEQ----EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574
Query: 460 R-ASLEGQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQAE 517
AS+E R Q E E +R + E +QQ EQ + Q +LL+E+ RL+ +
Sbjct: 2575 LVASMEEARRRQHEAEE-------GVRRKQEELQQLEQQRRQQEELLAEENQ---RLREQ 2624
Query: 518 LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
L+ E+ R L+ + +V ++ +TL R +D
Sbjct: 2625 LQLLEEQHR--AALAHSEEVTASQVAATKTLPNGRDALD 2661
Score = 66.2 bits (160), Expect = 7e-11
Identities = 125/581 (21%), Positives = 217/581 (37%), Gaps = 93/581 (16%)
Query: 8 AADDDERRRRPGAALEDSRSQEGAN-----GEAESGELSRLRAE---------------- 46
A D +++R L+ R A +AE+ E SRLR E
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 47 LAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ 106
GA E++ ++A AE +E+ K RQ QEE L+ ++D L
Sbjct: 1495 RGGAEGELQALRARAEEAEAQK--------RQAQEEAERLRRQVQDESQRKRQAEVELAS 1546
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME----KE 162
+ + + EK+R L L++L +A + E+++ +A + E+ R++ + +E
Sbjct: 1547 RVKAEAEAAREKQRALQALEELRLQA---EEAERRLRQA--EVERARQVQVALETAQRSA 1601
Query: 163 IEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAE 222
EL++K E +++R L + + EE AE
Sbjct: 1602 EAELQSKRASFAEKTAQLER---------------SLQEEHVAVAQLREEAERRAQQQAE 1646
Query: 223 AFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
A + + + L L + EE A S
Sbjct: 1647 AERAREEAERELERWQLKANEALRLRL---------QAEEVAQQKSLA------------ 1685
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q + Q E+ + E R+ K E R+R+ ++ L + + Q LA +E
Sbjct: 1686 --QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA----AE 1739
Query: 343 QLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG--- 399
Q L L+ Q +++ QL EL L E ++ Q L AE A
Sbjct: 1740 QELIRLRAETEQGEQQRQLLEEELAR----LQREAAAATQKRQELEAELAKVRAEMEVLL 1795
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
+ + + EEES +S Q+L + R R A+E R E + L EE A
Sbjct: 1796 ASKARAEEESRSTSEKSKQRL---EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1852
Query: 460 RASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAE-L 518
R E + + + + EA+ E+ ++E +L L ++ + RL+ +
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912
Query: 519 ETSEQVQRDFVRLSQALQVRLERIR--QAETLEQVRSIMDE 557
+ ++ +L +A LER + +TL Q R + +E
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Score = 60.5 bits (145), Expect = 4e-09
Identities = 115/476 (24%), Positives = 192/476 (40%), Gaps = 76/476 (15%)
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQME-KAHEDSEKLR-----EIVLP 158
++ER +QQ EE+ER L ++ L + L Q + +A ++++L+ E+V
Sbjct: 1373 EEERLAEQQRAEERER-LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 159 MEKEIEELKAKLLRAEELIQ-------EIQRRPRHAPSLHGSTELLPLS-RDPSPPLEPL 210
E ++ + K EEL Q EIQ + R A + S + R LE
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E G +A +++ + + + Q + E AS V
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA- 1550
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
+ E + + R LQ LE + + +E + LR++ + A+Q
Sbjct: 1551 --------------------EAEAAREKQRALQA-LEELRLQAEEAERRLRQAEVERARQ 1589
Query: 331 MQVLLAQVQNSEQLLRTLQGT-VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA 389
+QV L Q S + LQ S A++ QL+ + L EE+ +
Sbjct: 1590 VQVALETAQRSAEA--ELQSKRASFAEKTAQLE---------------RSLQEEH--VAV 1630
Query: 390 EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL 449
QL A + +QQ+ E + + EL++ + R RLQA+E ++ +L
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK------SL 1684
Query: 450 REALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRA 509
+A E+ A E + R + EE V + L E +R E + Q L +EQ
Sbjct: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQ-- 1740
Query: 510 KVLRLQAELETSEQVQRDFVRLSQALQVRLERI-RQAETLEQVRSIMDEAPLTDVR 564
+++RL+AE E EQ + Q L+ L R+ R+A Q R + EA L VR
Sbjct: 1741 ELIRLRAETEQGEQQR-------QLLEEELARLQREAAAATQKRQEL-EAELAKVR 1788
Score = 59.3 bits (142), Expect = 9e-09
Identities = 134/558 (24%), Positives = 227/558 (40%), Gaps = 99/558 (17%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE---------EVA 84
E G+L ++R+ A L +++T+ V ++ + E + A + Q +E E+
Sbjct: 1095 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE-EVLRAHEEQLKEAQAVPATLPELE 1153
Query: 85 SLQAILKDSISSYEAQ---ITALKQERQQQQQDCE-----------EKERELGRLKQLLS 130
+ +A LK + EAQ AL+ E + Q+ E E ER R+ QLL
Sbjct: 1154 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSL 190
R ++ Q + + E+L + + + L A L A ++IQ P L
Sbjct: 1214 R---WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-----L 1265
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
S + R LE +E G+ + FA ++ I + L + P
Sbjct: 1266 ADSQAVREQLRQEQALLEEIER-HGEKVEECQRFAKQYINA--IKDYELQLVTYKAQLEP 1322
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
+ P+ + + V + E + L T + +L T Q K +
Sbjct: 1323 VASPAKKPKVQSGSESV-----IQEYVDLR---------THYSELTTLTSQYIKFISETL 1368
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R +E + R E + + LA+V+ + + R L +QA+ + + + EL
Sbjct: 1369 RRMEEEE----RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---Q 1421
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + EV R E +A QQ++ +E ELQQL RQ + A
Sbjct: 1422 QRMQEEVVRREE------------AAVDAQQQKRSIQE-------ELQQL----RQSSEA 1458
Query: 431 RLQAQEHGAE-----RLRIE--IVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
+QA+ AE RLRIE I +R LE R EG+L+ R E EA
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL-QVRLE-- 540
+ E ER+++ Q+ D +R + L + ++ + R+ R QAL ++RL+
Sbjct: 1519 AQEEAERLRR-----QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1573
Query: 541 ----RIRQAETLEQVRSI 554
R+RQAE +E+ R +
Sbjct: 1574 EAERRLRQAE-VERARQV 1590
Score = 57.4 bits (137), Expect = 3e-08
Identities = 135/624 (21%), Positives = 236/624 (37%), Gaps = 99/624 (15%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRSQ-----EGANGEAESGELSRLRAELAG------A 50
AA + ++ ER ++ +R+Q E EAE R +AE A A
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 51 LAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQER 108
AEME K AE + KA E R EE + +L + + +A+ T ++R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Query: 109 QQQQQDC---EEKERELGRLKQLL---SRAYPLDSLEKQMEKAHEDSEKLREIVLPMEK- 161
Q +++ + EL +LK + +RA L + E++EK++++ +
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
Query: 162 -------------EIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
E+L + AE++++E + + A L ELL ++ + E
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--E 2368
Query: 209 PLEELSGDGGPAAEAFAHNCDD---------------SASISSFSLGGGVGSSSSL--PQ 251
L D A+ A SA L S + +
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428
Query: 252 SRQGLSPEQEETAS-LVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
Q + EE L T E + L + Q +Q + +L++ + +
Sbjct: 2429 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQ-----TLEIQRQQSDHDAERLREAIAELE 2483
Query: 311 RERDELQEGLR----RSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAEL 366
RE+++LQ+ + +S E Q + LL + Q +Q + + ++ Q + ++ + A+L
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 367 VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQ 426
+ + ++L EE Q QQ+Q E+E +Q L + +
Sbjct: 2544 EQLFQDEVAKAQQLREEQQ--------------RQQQQMEQE---------RQRLVASME 2580
Query: 427 EARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRT 486
EAR R E G R + E+ L + ++ A +L RE+ ++LE +
Sbjct: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALA 2637
Query: 487 EMERVQQEQSKA--QLP---DLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLER 541
E V Q A LP D L A +AE E S R V + + +
Sbjct: 2638 HSEEVTASQVAATKTLPNGRDALDGPAA-----EAEPEHSFDGLRRKVSAQRLQEAGILS 2692
Query: 542 IRQAETLEQVRSIMDE-APLTDVR 564
+ + L Q + +DE A DVR
Sbjct: 2693 AEELQRLAQGHTTVDELARREDVR 2716
Score = 34.3 bits (77), Expect = 0.32
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 13/198 (6%)
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+ ++L + +L +++L + +R Q + +++ E +++P+++P
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
EL+ ++ RA+ +AQ+ + LR E+ +E E + ++ RE
Sbjct: 1151 ELEATKASLKK-LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 476 VL----EASLCSLRTEMERVQQ--------EQSKAQLPDLLSEQRAKVLRLQAELETSEQ 523
L +A L ++Q +S L L + R + ++QA Q
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 524 VQRDFVRLSQALQVRLER 541
R+ +R QAL +ER
Sbjct: 1270 AVREQLRQEQALLEEIER 1287
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 78.2 bits (191), Expect = 2e-14
Identities = 139/567 (24%), Positives = 226/567 (39%), Gaps = 114/567 (20%)
Query: 12 DERRRRPGAALEDSRSQEGAN-GEAESG--ELSRLRAELAGALAEMETMKAVAEVSESTK 68
+E + + A LE++R+ G GE +G E+ R R E L E+ + + +
Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRL 1299
Query: 69 AEAVAAVQ------RQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKEREL 122
+A +Q + ++E L+ + EA + ++QE Q Q+ +E+E E
Sbjct: 1300 GRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEF 1359
Query: 123 ---------------GRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELK 167
G KQ L A LE ++E A ++ +L + E + L+
Sbjct: 1360 RTRERRLLGSLEEARGTEKQQLDHAR---GLELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
Query: 168 AKLLRAEELIQEIQRRPRHAPSLHGSTELLP----LSRDPSPPLEPLEELSGDGGPAAEA 223
A+L R E +QRR A L G L L R PSP P+ G PA +A
Sbjct: 1417 AELARVE-----VQRRAAEA-QLGGLRSALRRGLGLGRAPSPAPRPVP-----GSPARDA 1465
Query: 224 FAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPG 283
A G G+ S S+L S P S S
Sbjct: 1466 PAEGS-----------GEGLNSPSTLECSPGSQPPSPGPATSPAS--------------- 1499
Query: 284 YQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQ 343
PD E ++ R+ ++L S RERDE LR +Q+ + A+ ++
Sbjct: 1500 ----PDLDPEAVRGALREFLQELRSAQRERDE----LRTQTSALNRQLAEMEAERDSATS 1551
Query: 344 LLRTLQGTVSQAQERVQLQMAEL--VTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQ 401
R LQ V++++E + L V L E R +E + +Q+ +
Sbjct: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL------ 1605
Query: 402 QEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETV--- 458
E SL ++ EL+ QE ++++A E E + + + +A E TV
Sbjct: 1606 -----ERSLQATESELR-----ASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
Query: 459 -ARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQ-- 515
R SLEG+L+ R EA +L+ ++ +Q++ + SE +A L+L
Sbjct: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVAD-------SEVKAGTLQLTVE 1708
Query: 516 ------AELETSEQVQRDFVR-LSQAL 535
A++E SE RD VR L++AL
Sbjct: 1709 RLNGALAKVEESEGALRDKVRGLTEAL 1735
Score = 76.6 bits (187), Expect = 6e-14
Identities = 132/561 (23%), Positives = 237/561 (42%), Gaps = 68/561 (12%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAV-AEVSES-TKAE 70
ER R LE RS + EL +R L+ A + + ++A AEV+E+ TKAE
Sbjct: 662 ERSHRQLEQLEGKRS-------VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLS 130
A ++ + +A L+DS+S A +L Q++ + + E E L+
Sbjct: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRR---PRHA 187
+A E++ A E+ E+L E+ L E + L+ L AE+ + ++++ RH
Sbjct: 775 QA------EQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 188 PSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSS 247
S +L LSR S + LE+ + EA + +++ G V
Sbjct: 829 RS-QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAV---Q 884
Query: 248 SLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLE 307
+ R+G + +E T + L EG + + EQL+ EG+ L E
Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEAL--EGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 308 SVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELV 367
+++ E L++ + + E + + L+AQ + QA+ Q + E
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKE-LMAQ-------------KLVQAEREAQASLREQR 988
Query: 368 TTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQE 427
H+ +++RL E + E A SQ ++ +EE L E ++L +E
Sbjct: 989 AAHE---EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL----SEE 1041
Query: 428 ARARLQAQEHG---AERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSL 484
A Q ++ G AE + + ++L+E+ E+T L G SL ++
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLKES--EKTALSEKLMG-----------TRHSLATI 1088
Query: 485 RTEMER------VQQEQSKAQLPDLLSEQR-AKVLRLQAELETSEQVQRDFVRLSQALQV 537
EMER +QEQ ++ + L SE R + R +A +++V+R + +
Sbjct: 1089 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
Query: 538 RLERIRQAETLEQVRSIMDEA 558
R +R+AE L ++++A
Sbjct: 1149 RDSCLREAEELRTQLRLLEDA 1169
Score = 72.4 bits (176), Expect = 1e-12
Identities = 138/594 (23%), Positives = 236/594 (39%), Gaps = 81/594 (13%)
Query: 16 RRPGAALEDSRSQEGANGEA---ESGELSRLRAELAGALAEMETMKAVAEV------SES 66
R A+L+DS S+ A E+ + +L+RL A+L + ++ + AE E
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ 787
Query: 67 TKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK 126
+ E + Q ++ + + + + + E Q+ L+ ER Q Q+ + R
Sbjct: 788 ERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR------ 841
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEE----LIQEIQR 182
QL R L+ ++ ++ E E+ + KE L +L+ AE L +E R
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 183 RPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
+L GS L + R + E+L +G A + A + +
Sbjct: 902 LRLEKEALEGS--LFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ 959
Query: 243 VGSSSSLPQSRQGL-SPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
+S Q L E+E ASL E + Q + W +L+ E Q
Sbjct: 960 EKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL----QRLQREKEAAWRELEAERAQ 1015
Query: 302 LQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQL 361
LQ L+ RE++EL L E+ ++++ L Q + E LL S+ Q+ + L
Sbjct: 1016 LQSQLQ---REQEELLARLEAEKEELSEEIAAL--QQERDEGLLL----AESEKQQALSL 1066
Query: 362 QMAELVTTHKCL---HHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPEL- 417
+ +E + L H + ++ L E+ A +Q++ +L S + +L
Sbjct: 1067 KESEKTALSEKLMGTRHSLATIS-----LEMERQKRDAQSRQEQDRSTVNALTSELRDLR 1121
Query: 418 ---QQLLCCTRQEARARLQAQEHG-----------AERLRIEIVTL--------REALEE 455
++ QE R RLQ Q AE LR ++ L RE LE
Sbjct: 1122 AQREEAAAAHAQEVR-RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA 1180
Query: 456 ETVARASLEGQLRVQREETEVLEASLC-------SLRTEMERVQQEQSKAQLP----DLL 504
+ R S EG+ VQR+E L SL +LR E ++ KA+ L
Sbjct: 1181 QRKLRESQEGR-EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
Query: 505 SEQRAKVLRLQAELETSEQVQRDFVR--LSQALQVRLERIRQAETLEQVRSIMD 556
+E + + L L E T+ + +R L + + RLE R+ + L + ++D
Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
Score = 72.0 bits (175), Expect = 1e-12
Identities = 134/555 (24%), Positives = 213/555 (38%), Gaps = 80/555 (14%)
Query: 46 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALK 105
+L G LA A + ST + E+ A LQA L++ + + L
Sbjct: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLA 382
Query: 106 QERQQQ---QQDCEEKERELG-RLKQLLSRAYPLDSLEKQMEKAHEDSEKLR-------- 153
Q++ Q + D + ELG +K+L + D + K + + E E LR
Sbjct: 383 QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
Query: 154 -EIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE--PL 210
E +++ + +L +L E ++ R A + +GS L R PSPP P
Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
Query: 211 EELSGDGGPAAE-------AFAHNCDDSASISSFSLGGGVGSSSSL-----------PQS 252
S GP+ A H+ + + G +S L
Sbjct: 503 RGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESE 562
Query: 253 RQGLSPE------------------QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQ 294
R+ L + Q E L S L+ Q V Q E+
Sbjct: 563 RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ-VAQQQAEE 621
Query: 295 LQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQ 354
L+ E +LQ E + R+RD L+E ED + + +++ S + L L+G S
Sbjct: 622 LRQEREKLQAAQEELRRQRDRLEE----EQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677
Query: 355 -AQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSS 413
A+E V+++ A T + + ++ +AE + + EE SL S
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS 737
Query: 414 VPELQQL-------------LCCTRQEARARLQAQEHGAER----LRIEIVTLREALEEE 456
+ +L L L +E ++ LQ ++ AE+ R E L E E+
Sbjct: 738 LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797
Query: 457 TVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLS--EQRAKVLRL 514
VAR LEG LRV + E LE L +LR ER Q ++ AQL LS EQ + R
Sbjct: 798 EVARQGLEGSLRVAEQAQEALEQQLPTLR--HERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 515 QA--ELETSEQVQRD 527
+A ++E E+ R+
Sbjct: 856 EAQRQVEALERAARE 870
Score = 71.6 bits (174), Expect = 2e-12
Identities = 133/595 (22%), Positives = 244/595 (41%), Gaps = 94/595 (15%)
Query: 14 RRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVA 73
RR PG R A ++S L+ + + L +++ M+ E S+ + +
Sbjct: 497 RRSSPGRGRSPRRGPSPAC--SDSSTLALIHSALHKRQLQVQDMRGRYEASQ----DLLG 550
Query: 74 AVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK---QLLS 130
+++Q + + +A+ E Q+ L+ + Q E+ +RE+ RL+ +LLS
Sbjct: 551 TLRKQLSDSESERRAL--------EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS 602
Query: 131 RAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEE-----------LIQE 179
R +L ++ A + +E+LR+ ++ EEL+ + R EE + +E
Sbjct: 603 REK--SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE 660
Query: 180 IQRRPRHAPSLHG-----STELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASI 234
++R R L G + EL+ + S + L + AEA
Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTK-------- 712
Query: 235 SSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG-TLVPEGIYLPPPGYQLVPDTQWE 293
+ G V S+ + R + Q+ + L + +L + + L +LV + E
Sbjct: 713 ---AEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL----NRLVAQLEEE 765
Query: 294 QLQTEGRQLQKDLE-SVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTV 352
+ +GRQ Q + E +V+RE E E LR E + ++ L + +++ L T+
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 353 SQAQERVQLQMAEL---------------------VTTHKCLHHEVKRLNEENQGLRAEQ 391
+ ++Q Q+A+L V + E + L +E+ GL +
Sbjct: 826 RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL 885
Query: 392 LPSSAPQGSQQEQG-----EEESLPSSVPELQQLLC---CTRQEARARLQAQEHGAERLR 443
+ + + E+ E+E+L S+ E+Q+ L R++ A QA E L
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLT 945
Query: 444 IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDL 503
E+ LR+ + T +ASL+ +L Q+ L E + +EQ A DL
Sbjct: 946 GELAGLRQQI-IATQEKASLDKELMAQK---------LVQAEREAQASLREQRAAHEEDL 995
Query: 504 LSEQRAKVLRLQAELETSE-QVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDE 557
QR K + ELE Q+Q R + L RLE ++ E E++ ++ E
Sbjct: 996 QRLQREKEAAWR-ELEAERAQLQSQLQREQEELLARLEAEKE-ELSEEIAALQQE 1048
Score = 67.0 bits (162), Expect = 4e-11
Identities = 133/589 (22%), Positives = 231/589 (39%), Gaps = 66/589 (11%)
Query: 22 LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81
L DS S+ A E +L RLR + GA+ E A+ R E
Sbjct: 556 LSDSESERRALEE----QLQRLRDKTDGAMQAHED------------AQREVQRLRSANE 599
Query: 82 EVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDS-LEK 140
++ ++ L S+ + Q L+QER++ Q EE R+ RL++ A + + +
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
Query: 141 QMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLS 200
++E++H E+L + KE+ E++ L RA +Q E +
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
Query: 201 RDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQ 260
+ S EE S + + + + L + S Q RQ + EQ
Sbjct: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQA-EQ 778
Query: 261 EETASLVSTGTLVP------------EGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLES 308
E T + L EG Q + Q L+ E QLQ+ L
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 309 VSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG-------------TVSQA 355
+SR+ ++ L ++ + +Q++ L + E L + G T+S+
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA---------EQLPSSAPQGSQQEQGE 406
R++L+ L + + ++ +L + L A E L QQ
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958
Query: 407 EESLPSSVPELQQLLCCTRQEARARLQ----AQEHGAERLRIEIVTLREALEEETVARAS 462
+E + Q L +EA+A L+ A E +RL+ E LE E RA
Sbjct: 959 QEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAE---RAQ 1015
Query: 463 LEGQLRVQREETEV---LEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELE 519
L+ QL QRE+ E+ LEA L E+ +QQE+ + L +Q+A L+ +
Sbjct: 1016 LQSQL--QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 520 TSEQVQRDFVRLSQ-ALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIK 567
SE++ L+ +L++ ++ EQ RS ++ A +++RD++
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN-ALTSELRDLR 1121
Score = 50.1 bits (118), Expect = 6e-06
Identities = 130/560 (23%), Positives = 219/560 (39%), Gaps = 101/560 (18%)
Query: 3 AAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAE 62
A +P + D D R GA E QE + + E EL + L LAEME +
Sbjct: 1494 ATSPASPDLDPEAVR-GALREFL--QELRSAQRERDELRTQTSALNRQLAEMEAER---- 1546
Query: 63 VSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKEREL 122
++ + RQ Q+ VA + ++ S + +++ ++ E Q++ ERE
Sbjct: 1547 -------DSATSRARQLQKAVAESE----EARRSVDGRLSGVQAELALQEESVRRSERER 1595
Query: 123 -GRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEE--LIQE 179
L Q+ + L + E ++ + E K++ +E + LK L +E + E
Sbjct: 1596 RATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
Query: 180 IQRRPRHAPSLHGSTELLPLS-RDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFS 238
+QRR SL G + L D + L++ D A + + ++
Sbjct: 1656 LQRR-----SLEGELQRSRLGLSDREAQAQALQDRV-DSLQRQVADSEVKAGTLQLTVER 1709
Query: 239 LGGGVG----SSSSLPQSRQGLSPE-QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWE 293
L G + S +L +GL+ + +ASL ST
Sbjct: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNST------------------------ 1745
Query: 294 QLQTEGRQLQKDLESVSRERDELQEGL----------RRSNEDCAKQMQVLLAQVQNSEQ 343
+ + LQK L + +R LQE L R+ + +Q+Q L +V + E
Sbjct: 1746 --RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL 1803
Query: 344 LLRTLQGTVSQAQE----RVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG 399
+G + Q +E R + + A L T K + +RL +E G S +
Sbjct: 1804 QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL--QDERRLLQERLG--------SLQRA 1853
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALE----E 455
Q + E+ + S L++ R R L E E+LR T+R + E +
Sbjct: 1854 LAQLEAEKREVERSALRLEK----DRVALRRTLDKVER--EKLRSHEDTVRLSAEKGRLD 1907
Query: 456 ETVARASLE---GQLRVQREETEV--LEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
T+ A LE Q ++Q+ E +V LE S + E++ QQ+ Q + L +A+
Sbjct: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQ 1967
Query: 511 VLRLQAELETSEQVQRDFVR 530
R LE E+ R VR
Sbjct: 1968 TER---TLEARERAHRQRVR 1984
Score = 47.4 bits (111), Expect = 4e-05
Identities = 105/468 (22%), Positives = 179/468 (38%), Gaps = 83/468 (17%)
Query: 13 ERRRRPG----AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTK 68
ER RR A LE S + A ++S+++A + +K V + SES
Sbjct: 1592 ERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT 1651
Query: 69 AEAVAAVQRQCQEEVASLQAILKDS---ISSYEAQITALKQERQQQQQDCEEKERELGRL 125
+ +QR+ SL+ L+ S +S EAQ AL+ Q+ + E + G L
Sbjct: 1652 VKL--ELQRR------SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTL 1703
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQR--- 182
+ + R L + K E LR+ V + + + + A L + +Q+
Sbjct: 1704 QLTVER------LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
Query: 183 -----RPRHAPSLHGSTELLPLSRDPSPPL-EPLEELSGDGGPAAEAFAHNCDDSASISS 236
R L + + L +R S L E ++ L G+ ++
Sbjct: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGE-----------------VAD 1800
Query: 237 FSLGGGVGSSSSLPQSRQGLSPEQE-ETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQL 295
L V + L Q R+ L QE E A+L + L E L L QL
Sbjct: 1801 LELQR-VEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSL--QRALAQL 1857
Query: 296 QTEGRQ-------LQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTL 348
+ E R+ L+KD ++ R D+++ RS+ED + L A+ ++ L
Sbjct: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR----LSAEKGRLDRTLTGA 1913
Query: 349 QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408
+ +++AQ ++Q A++V L P+ +QQ+Q E
Sbjct: 1914 ELELAEAQRQIQQLEAQVVV------------------LEQSHSPAQLEVDAQQQQLE-- 1953
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEE 456
L V L+ T + AR +A L ++ TL+ L++E
Sbjct: 1954 -LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000
Score = 41.6 bits (96), Expect = 0.002
Identities = 78/308 (25%), Positives = 127/308 (41%), Gaps = 57/308 (18%)
Query: 295 LQTEGRQLQKDLESVSR----------ERDELQEGLRRSNEDCAK---QMQVLLAQVQNS 341
LQ +L+ E +S+ ++ L+E L S K Q + L ++Q S
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRS 1668
Query: 342 EQLLRTLQGTVSQAQERV---QLQMAELVTTHKCLHHEVKRLN------EENQGLRAEQL 392
L + Q+RV Q Q+A+ L V+RLN EE++G +++
Sbjct: 1669 RLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728
Query: 393 PSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQE---ARARLQAQEHGAERLRIEIVTL 449
+G E+L S L TR + + L A EH + L+ +
Sbjct: 1729 -----------RGLTEALAQSSASLNS----TRDKNLHLQKALTACEHDRQVLQERLDAA 1773
Query: 450 REALEEETVARASLEGQLRVQREETEVL-------EASLCSLRTEMERVQQEQSKA---- 498
R+AL E +SL Q++ R E L E L LR + + Q+ ++ A
Sbjct: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV 1833
Query: 499 -QLPD---LLSEQRAKVLRLQAELETSE-QVQRDFVRLSQALQVRLERIRQAETLEQVRS 553
+L D LL E+ + R A+LE + +V+R +RL + +V L R E++RS
Sbjct: 1834 QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD-RVALRRTLDKVEREKLRS 1892
Query: 554 IMDEAPLT 561
D L+
Sbjct: 1893 HEDTVRLS 1900
Score = 37.7 bits (86), Expect = 0.029
Identities = 68/308 (22%), Positives = 130/308 (42%), Gaps = 45/308 (14%)
Query: 285 QLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQL 344
QLV Q + LQ + R + + + + R + Q+ LR + ++ ++ L +++ +Q
Sbjct: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEH--SQDLESALIRLEEEQQR 228
Query: 345 LRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQ 404
+L +Q ++ Q+ + + ++ L +++++ + R E A ++E
Sbjct: 229 SASL----AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEES 284
Query: 405 -----GEEES--------------LPSSVPELQQ--LLCCTRQEARARLQAQEHG---AE 440
E S L S V + LL + AR QE G +
Sbjct: 285 FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLST 344
Query: 441 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQL 500
LR+ ALE++ + +A LE QLR + + E L +++Q + KA L
Sbjct: 345 GLRLAESRAEAALEKQALLQAQLEEQLR----DKVLREKDLAQ-----QQMQSDLDKADL 395
Query: 501 PDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQ-VRLERIRQAET-----LEQVRSI 554
++E V RL+ + +QV +D +AL+ +RL+ ET L+Q
Sbjct: 396 SARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRD 455
Query: 555 MDEAPLTD 562
+ +A L+D
Sbjct: 456 LAQAVLSD 463
Score = 36.2 bits (82), Expect = 0.083
Identities = 48/158 (30%), Positives = 73/158 (46%), Gaps = 28/158 (17%)
Query: 399 GSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETV 458
G + Q E +L + + L+ + C + AR AQ+ +T AL E V
Sbjct: 4 GLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQ--------ITSLPALIREIV 55
Query: 459 ARASLEGQLRVQREETEVLEASLCSLRTEMERVQQE---------QSKAQLPDL------ 503
R + + V TE+ ASL SL+ E + +QQE QS+A+ +L
Sbjct: 56 TRNLSQPESPVLLPATEM--ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNA 113
Query: 504 LSEQRAKVLRLQ-AELETSEQVQRDFVRLSQALQVRLE 540
+SE+ + LRL+ ELET E R VR S L+ +L+
Sbjct: 114 VSERLEQALRLEPGELETQE--PRGLVRQSVELRRQLQ 149
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 77.0 bits (188), Expect = 4e-14
Identities = 127/572 (22%), Positives = 234/572 (40%), Gaps = 108/572 (18%)
Query: 15 RRRPGAALEDSRSQEGANGEAE----SGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
R R AL+ + +E A+ + E + R +L ++ + AV E +
Sbjct: 493 RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSA 552
Query: 71 AVAAVQRQCQE---EVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQ 127
V +QR+ +E E Q++ + + + + A KQE Q + + EE E ELG
Sbjct: 553 LVRGLQRELEETSEETGHWQSMFQKN----KEDLRATKQELLQLRMEKEEMEEELGE--- 605
Query: 128 LLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ--RRPR 185
++ L++++E+A + R ++E LK +LLR +E ++E+Q R+ +
Sbjct: 606 ------KIEVLQRELEQARASAGDTR--------QVEVLKKELLRTQEELKELQAERQSQ 651
Query: 186 HAPSLHGSTEL---LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDS------ASISS 236
H EL L + R + LEE + + +C+++ A +
Sbjct: 652 EVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEA 711
Query: 237 FSLGGGVGSSSSLPQSRQ-----------GLSPEQEETASLVSTGTLVPEGIYLPPPGYQ 285
LG + + + Q GL + +ET LV G V +
Sbjct: 712 TVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARL-------- 763
Query: 286 LVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLL 345
+ ++L+ E +QL++ L + S+E + +R+ E ++ Q LA++ +Q L
Sbjct: 764 ---RDKLQRLEAEKQQLEEAL-NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 346 RTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQG 405
+ +E ++ AEL + L V RLN+E E++ + Q QQ Q
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE-----LEKIGEDSKQALQQLQA 874
Query: 406 EEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE---------RLRIEIVTLREALEEE 456
+ E R+ A A+ QA++ +E RL+ EI LR+AL+
Sbjct: 875 QLEDYKEK---------ARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQAS 925
Query: 457 TVAR--ASLEGQLRVQR-------------------EETEVLEASLCSLRTEMERVQQEQ 495
R A L+ +L QR + + LE + L TE++ +++
Sbjct: 926 QAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELD--EEKN 983
Query: 496 SKAQLPDLLSEQRAKVLRLQAELETSEQVQRD 527
+ L D ++ R +V +L+ EL ++D
Sbjct: 984 TVELLTDRVNRGRDQVDQLRTELMQERSARQD 1015
Score = 74.7 bits (182), Expect = 2e-13
Identities = 122/584 (20%), Positives = 228/584 (39%), Gaps = 113/584 (19%)
Query: 4 AAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEV 63
+ P D + PG+ + G E S + +R +++ L +M+ + V+
Sbjct: 294 STPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVS-- 351
Query: 64 SESTKAEA--------VAAVQRQCQEEVASLQAI------LKDSISSYEAQITALKQERQ 109
S STKA A V +QR+ EEV Q + L+ + + + L++ +
Sbjct: 352 SGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLE 411
Query: 110 QQQQDCEEKERELGRLKQLLSRAYPL------DSLEKQMEKAH-EDSEKLREIVLPMEKE 162
+++ + ++ +EL +K+LL + L +E Q + H + E +E++L E
Sbjct: 412 RRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLE 471
Query: 163 IEELKAKLLRAEELIQE-IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAA 221
EL ++L ++ ++E ++ R R +L G+ + SRD + +E +
Sbjct: 472 TRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRD-----QEVEHVRQQYQRDT 526
Query: 222 EAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPP 281
E + D+ Q L E+++ ++LV
Sbjct: 527 EQLRRSMQDAT------------------QDHAVLEAERQKMSALV-------------- 554
Query: 282 PGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS 341
R LQ++LE S E Q +++ ED Q LL
Sbjct: 555 ------------------RGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEK 596
Query: 342 EQLLRTLQGTVSQAQERVQLQMAELVTTH--KCLHHEVKRLNEENQGLRAEQLPSSAPQG 399
E++ L + Q ++ A T + L E+ R EE + L+AE +
Sbjct: 597 EEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAE-------RQ 649
Query: 400 SQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA 459
SQ+ G EL++ L R EA + +E + L+ + LR+ EE + A
Sbjct: 650 SQEVAGRHRD-----RELEKQLAVLRVEADRGRELEEQNLQ-LQKTLQQLRQDCEEASKA 703
Query: 460 --------------RASLEGQLRVQREETEVLEASLCSLRTEMERVQ-----QEQSKAQL 500
RA++E LR +EE + + L +++ + E +A+L
Sbjct: 704 KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARL 763
Query: 501 PDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQ 544
D L A+ +L+ L S++ + +AL+ RLE ++
Sbjct: 764 RDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQR 807
Score = 68.9 bits (167), Expect = 1e-11
Identities = 120/560 (21%), Positives = 218/560 (38%), Gaps = 102/560 (18%)
Query: 40 LSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQ------RQCQEEVASLQAILKDS 93
L R + E + E++ MK + + E + V + Q + + +LKD
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469
Query: 94 ISSYEAQITALKQERQQQQQDCEEKERELGRLK-----QLLSRAYPLDSLEKQMEKAHED 148
+ + E + + + +Q+ ++ +EREL LK ++ SR ++ + +Q ++ D
Sbjct: 470 LETREL-LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR---D 525
Query: 149 SEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLE 208
+E+LR + ++ L+A+ + L++ +QR
Sbjct: 526 TEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRE------------------------- 560
Query: 209 PLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVS 268
LEE S + G F N +D + + L Q R +EE +
Sbjct: 561 -LEETSEETGHWQSMFQKNKEDLRA-----------TKQELLQLRMEKEEMEEELGEKIE 608
Query: 269 TGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCA 328
L E L Q E L+ E + Q++L+ + ER + R + +
Sbjct: 609 V--LQRE---LEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
Query: 329 KQMQVLLAQVQNSE-------QLLRTLQGTVSQAQERVQLQM-AELVTT-----HKCLHH 375
KQ+ VL + QL +TLQ +E + +M AE T +
Sbjct: 664 KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
Query: 376 EVKRLNEENQGLRAE-----------------------QLPSSAPQGSQQEQGEEESLPS 412
++ EEN R +L + ++Q EE+L +
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA 783
Query: 413 SVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQRE 472
S E + L ++ ARL+ + G RL E TL ALEEE R L E
Sbjct: 784 SQEE-EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEE 842
Query: 473 ETEVLEASLCSLRTEMERVQQ------EQSKAQLPDLLSEQRAKVLRLQAEL-ETSEQVQ 525
+ +L+ ++ L E+E++ + +Q +AQL D + R +V Q + + + + +
Sbjct: 843 QKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAE 902
Query: 526 RDFVRLSQALQVRLERIRQA 545
+ LS+ LQ ++R+RQA
Sbjct: 903 KTSGGLSR-LQDEIQRLRQA 921
Score = 48.5 bits (114), Expect = 2e-05
Identities = 118/543 (21%), Positives = 213/543 (39%), Gaps = 67/543 (12%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSES 66
VA +R A+ + G E ++ +L + +L E K VAE +
Sbjct: 653 VAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAT 712
Query: 67 TKAEAVAAVQ---RQCQEE-------VASLQAILKDS---ISSYEA-------QITALKQ 106
+ AAV+ R+ QEE + L+ LK++ + EA ++ L+
Sbjct: 713 VLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEA 772
Query: 107 ERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEE- 165
E+QQ ++ + E G L A +LE ++E+A +L + + + +EE
Sbjct: 773 EKQQLEEALNASQEEEGSL------AAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826
Query: 166 -LKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEA- 223
+ ++LR + E Q+R + EL + D L+ L+ D A
Sbjct: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
Query: 224 ---FAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLP 280
D AS + + GG + + RQ L Q E T L E +
Sbjct: 887 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAER----DTARLDKELLAQR 942
Query: 281 PPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQN 340
G + + + RQL+ E VSR EL E +N
Sbjct: 943 LQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDE-------------------EKN 983
Query: 341 SEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGS 400
+ +LL ++++ ++ + + + L + L +N+ L+ +L SS +G
Sbjct: 984 TVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKT-RLASS--EGF 1040
Query: 401 QQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVAR 460
Q+ L S LQ+ L +E + LQ+ ER +++ ++++ E + V
Sbjct: 1041 QKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLER-KVKELSIQIEDERQHVND 1098
Query: 461 ASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELET 520
+ LRV+ + +V EA E+ER+ + KAQ + EQ +LQA +++
Sbjct: 1099 QKDQLSLRVKALKRQVDEA-----EEEIERLDGLRKKAQRE--VEEQHEVNEQLQARIKS 1151
Query: 521 SEQ 523
E+
Sbjct: 1152 LEK 1154
Score = 44.7 bits (104), Expect = 2e-04
Identities = 72/272 (26%), Positives = 120/272 (44%), Gaps = 64/272 (23%)
Query: 309 VSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVT 368
++R+ +ELQ R+ +E+ K+ ++ +QV QL + S+ QE ++ + E
Sbjct: 364 LTRKVEELQ---RKLDEEVKKRQKLEPSQVGLERQLEEKTE-ECSRLQELLERRKGEAQQ 419
Query: 369 THKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEA 428
++K L + +KRL ++ + LR L + V ELQ L
Sbjct: 420 SNKELQN-MKRLLDQGEDLR-------------------HGLETQVMELQNKL------- 452
Query: 429 RARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASL----CSL 484
+Q E E L +++ RE LEE + +E QLR++ E L+ +L S
Sbjct: 453 -KHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASR 511
Query: 485 RTEMERVQQ------EQSKAQLPD------LLSEQRAK----VLRLQAEL-ETSE----- 522
E+E V+Q EQ + + D +L +R K V LQ EL ETSE
Sbjct: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHW 571
Query: 523 ----QVQRDFVRLS--QALQVRLERIRQAETL 548
Q ++ +R + + LQ+R+E+ E L
Sbjct: 572 QSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603
Score = 33.5 bits (75), Expect = 0.54
Identities = 23/118 (19%), Positives = 57/118 (48%), Gaps = 9/118 (7%)
Query: 48 AGALAEMETMKAVAEV---SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITAL 104
+ +L+++E+ + + +E + + + R+ + +V L ++D Q L
Sbjct: 1044 SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQL 1103
Query: 105 KQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKE 162
+ ++ +E E E+ RL L +A ++++E+ HE +E+L+ + +EK+
Sbjct: 1104 SLRVKALKRQVDEAEEEIERLDGLRKKA------QREVEEQHEVNEQLQARIKSLEKD 1155
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 76.6 bits (187), Expect = 6e-14
Identities = 135/575 (23%), Positives = 240/575 (41%), Gaps = 97/575 (16%)
Query: 37 SGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSIS- 95
S + L ELA A + ++ E K E + + + + V LQ + +++I
Sbjct: 246 SEDKQHLAVELADTKARLRRVRQELE----DKTEQLVDTRHEVDQLVLELQKVKQENIQL 301
Query: 96 --------SYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHE 147
+Y ++ +L+++ + E E EL R K+ L + +D + +ME+ E
Sbjct: 302 AADARSARAYRDELDSLREKANR----VERLELELTRCKEKL---HDVDFYKARMEELRE 354
Query: 148 DSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPL 207
D+ L E +E+++ +A+ + EL +E +L ++L L D
Sbjct: 355 DNIILIETKAMLEEQLTAARARGDKVHELEKE---------NLQLKSKLHDLELDRDTDK 405
Query: 208 EPLEEL-----------------SGDGGPAAEAFAHNCDDS-ASISSFSLGGGVGSSS-- 247
+ +EEL S G E + N D S AS SF +SS
Sbjct: 406 KRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRI 465
Query: 248 --------SLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEG 299
SL + QGL ++ + L +G E L +QL + Q Q E
Sbjct: 466 LKLEKENQSLQSTIQGL---RDASLVLEESGLKCGE---LEKENHQLSKKIEKLQTQLER 519
Query: 300 -RQLQKDLESVS----RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQ 354
+Q +DLE++S RE+++LQ + D A+Q++ L Q + L R + +
Sbjct: 520 EKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDL---EQEKDHLNRAMWSLRER 576
Query: 355 AQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEE-ESLPSS 413
+Q + +M ++ +K LH V N + L E+ +E+GE E L
Sbjct: 577 SQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERE 636
Query: 414 VPELQQ------LLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQL 467
+ LQ+ + + A +++A EH ++ L++E TLR++L +T+ SL QL
Sbjct: 637 LQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSL--DTLQNVSL--QL 692
Query: 468 RVQREETEVLEASLCSLR--------TEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELE 519
+ + L+A LR T + Q E+ QL E R V L+A +
Sbjct: 693 EGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK 752
Query: 520 TSEQVQRDF-------VRLSQALQVRLERIRQAET 547
SE+++ + +RL Q+L+ + + E+
Sbjct: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
Score = 55.1 bits (131), Expect = 2e-07
Identities = 118/545 (21%), Positives = 217/545 (39%), Gaps = 80/545 (14%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDS 93
+AE+ EL RL + ++ M+ + E K E V + + L+ S
Sbjct: 703 DAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD--LLKALGKKSERLELS 760
Query: 94 ISSYEAQITALKQERQQQQQDCEEKERELGRL---KQLLSRAYP-LDSLEKQMEKAHEDS 149
S A+ L+Q + + E ELG L +Q L R L Q+E A +D
Sbjct: 761 YQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDR 820
Query: 150 EKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEP 209
+ L + V +EK+ + L+ + A+ L Q+++ + L ST L S L+
Sbjct: 821 KALEQEVAQLEKDKKLLEKE---AKRLWQQVELKD---AVLDDSTAKLSAVEKESRALD- 873
Query: 210 LEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVST 269
+EL+ C D+A G L + + L+ + A ++T
Sbjct: 874 -KELA------------RCRDAA-----------GKLKELEKDNRDLTKQVTVHARTLTT 909
Query: 270 GTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDE--LQEGLRRSNEDC 327
L D E+L+++ QL +L+ +S+E ++ L L +D
Sbjct: 910 ----------------LREDLVLEKLKSQ--QLSSELDKLSQELEKVGLNRELLLQEDDS 951
Query: 328 AKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQL---QMAELVTTHKCLHHEVKRLNEEN 384
+ + + +N E L+T T++ +E++ L QM E + ++ L E++ L +E
Sbjct: 952 GSDTKYKILEGRN-ESALKT---TLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
Query: 385 QGLRAEQ---------LPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQ 435
+ LR Q A + + QG+E P +LL + R
Sbjct: 1008 ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL-----RVKDRAIEL 1062
Query: 436 EHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQ 495
E L+ E L+E L+ + Q+ ++++ L+ +L+T+ ++Q E
Sbjct: 1063 ERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVEN 1122
Query: 496 S--KAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRS 553
S +Q L ++ A+ +E +QR +L+ A + L+ TL + +S
Sbjct: 1123 STLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQS 1182
Query: 554 IMDEA 558
EA
Sbjct: 1183 AEYEA 1187
Score = 40.4 bits (93), Expect = 0.004
Identities = 99/473 (20%), Positives = 193/473 (40%), Gaps = 67/473 (14%)
Query: 115 CEEKERELGRLKQL-LSRAYPLDSLEKQMEKAHEDSEKLREIVLP--MEKEIEEL-KAKL 170
CE KE + R+KQL + + + +++ E+ L+ + LP +E+E L ++ +
Sbjct: 134 CERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMV 193
Query: 171 LRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDD 230
L LI + L + L PS P++ S D P+ + + D
Sbjct: 194 LHLRRLIDQRDECTELIVDLTQERDYLQAQHPPS----PIKSSSADSTPSPTSSLSSEDK 249
Query: 231 SASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDT 290
+ + + L + RQ L +++T LV T V QLV +
Sbjct: 250 QHLAVELA-----DTKARLRRVRQEL---EDKTEQLVDTRHEVD----------QLVLEL 291
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q +++ E QL D S RDEL ++N +++++ L + + + +
Sbjct: 292 Q--KVKQENIQLAADARSARAYRDELDSLREKANR--VERLELELTRCKEKLHDVDFYKA 347
Query: 351 TVSQAQE------RVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQ 404
+ + +E + + E +T + +V L +EN L+++ + + +++
Sbjct: 348 RMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKR 407
Query: 405 GEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLE 464
EE + V E+ A+ Q+ A L E+ L + + +R S
Sbjct: 408 IEELLEENMVLEI------------AQKQSMNESA-HLGWELEQLSKNADLSDASRKSFV 454
Query: 465 GQL------RVQR--EETEVLEASLCSLRTEMERVQQEQSK-AQLPDLLSEQRAKVLRLQ 515
+L R+ + +E + L++++ LR +++ K +L + K+ +LQ
Sbjct: 455 FELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQ 514
Query: 516 AELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKD 568
+LE +Q +D LS+ E IR+ EQ++S M+ R IKD
Sbjct: 515 TQLEREKQSNQDLETLSE------ELIREK---EQLQSDMETLKADKARQIKD 558
Score = 36.6 bits (83), Expect = 0.064
Identities = 113/561 (20%), Positives = 212/561 (37%), Gaps = 86/561 (15%)
Query: 31 ANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKA--EAVAAVQRQCQEEVASLQA 88
A E E+ +L R + EL ++ +KA+ + SE + ++V+A + Q+ + S
Sbjct: 724 AQMERENQQLEREKEELR---KNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS- 779
Query: 89 ILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHED 148
+ E+++ L+ ERQ ++D E +L+ L+ Q+EK +
Sbjct: 780 ---HKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKL 836
Query: 149 SEK----------LREIVLP--------MEKEIEELKAKLLRAEEL---IQEIQRRPR-- 185
EK L++ VL +EKE L +L R + ++E+++ R
Sbjct: 837 LEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDL 896
Query: 186 ------HAPSLHGSTELLPL----SRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASIS 235
HA +L E L L S+ S L+ L + G E DDS S +
Sbjct: 897 TKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQE-DDSGSDT 955
Query: 236 SFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQL 295
+ + G S+ + L+ ++E+ L + Q E+
Sbjct: 956 KYKILEGRNESAL----KTTLAMKEEKIVLL----------------------EAQMEEK 989
Query: 296 QTEGRQLQKDLESVSRERDELQE--GLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVS 353
+ RQL+ +L+ + +E + L++ G + ++ K A ++ +
Sbjct: 990 ASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEAT 1049
Query: 354 QAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSS 413
RV+ + EL + L E + L E+ Q L + + S+ + Q+Q
Sbjct: 1050 MELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSA------- 1102
Query: 414 VPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREE 473
Q T Q A+LQ + + L+ A+ + L+ Q+E+
Sbjct: 1103 ---FLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQ 1159
Query: 474 TEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQR--DFVRL 531
+L + + + QS + K L ELE E +R D ++
Sbjct: 1160 LTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKR 1219
Query: 532 SQALQVRLERI--RQAETLEQ 550
L+ R E++ + E L+Q
Sbjct: 1220 KAELEER-EKVLTTEREALQQ 1239
Score = 33.5 bits (75), Expect = 0.54
Identities = 29/132 (21%), Positives = 59/132 (44%), Gaps = 3/132 (2%)
Query: 54 METMKAVAEVSESTKAEAVAAVQRQCQ--EEVASLQAILKDSISSYEAQITALKQERQQQ 111
++T A +V ST + AA+ Q + + + +S+ + Q+TA + Q
Sbjct: 1111 LQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQD 1170
Query: 112 QQDCEE-KERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKL 170
+ ER+ + L+ + L +L + +E H++ + +L + E+EE + L
Sbjct: 1171 HEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVL 1230
Query: 171 LRAEELIQEIQR 182
E +Q+ QR
Sbjct: 1231 TTEREALQQEQR 1242
Score = 33.1 bits (74), Expect = 0.70
Identities = 57/262 (21%), Positives = 95/262 (36%), Gaps = 32/262 (12%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAV 72
E R + ++ QE GE RLR EL +K E + E
Sbjct: 1224 EEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELK 1283
Query: 73 AAVQRQCQEEVASLQAI---LKDSISSYEAQITALKQERQ---QQQQDCEEKERELGRLK 126
++ Q E+ QA LK+ + + +T L + + + + EE+ L
Sbjct: 1284 TSLNN-AQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQI 1342
Query: 127 QLLSRAYPLDSLEKQMEKA---HEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRR 183
QLLS+ + LE+ ME HE+ ++ + + + + E+L+ K++ + ++
Sbjct: 1343 QLLSQQNQM-LLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKK 1401
Query: 184 PRH-----------APSLHGSTELLPL----------SRDPSPPLEPLEELSGDGGPAAE 222
H P GS E L S DP+ P S P
Sbjct: 1402 KNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTP 1461
Query: 223 AFAHNCDDSASISSFSLGGGVG 244
A NC + + S+G G G
Sbjct: 1462 ALGSNCAEERDAHNGSVGKGPG 1483
>gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
[Homo sapiens]
Length = 871
Score = 76.3 bits (186), Expect = 7e-14
Identities = 132/582 (22%), Positives = 237/582 (40%), Gaps = 64/582 (10%)
Query: 22 LEDSRSQEGANGEAESGELSRL-RAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
L ++ Q+ EA++ EL L RAE AG AE E ++A +E + QR+ +
Sbjct: 200 LRETSLQQKMRLEAQAMELEALARAEKAGR-AEAEGLRAALAGAEVVRKNLEEGSQRELE 258
Query: 81 EEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKE-RELGRLKQLLSRAYPLDSLE 139
E Q L ++E +++L + + ++ E R G K+L + L
Sbjct: 259 EVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLR 318
Query: 140 KQMEKAHEDSEKLREIVLPMEKEI-EELKAKL------LRAEELIQEIQRRPRHAPSLHG 192
KQ+ K ED E +V + K + E++ +++ L ++L++ +Q SLH
Sbjct: 319 KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHA 378
Query: 193 STELLPLSRDPSPPLEPL--EELSGDGGPAAEA---FAHNCDD----------------- 230
+ ELL + + L EEL+ P+ F C
Sbjct: 379 TAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLK 438
Query: 231 ----SASISSFSLGGGVGSS----SSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
S S L G V S +S Q + L ++ A+ V + +G+ L
Sbjct: 439 AQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELS 498
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q +Q + QL+ + +VS + L+ + + E A Q+ L ++ +
Sbjct: 499 RAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKV-EGAAAQLPSLNNRLSYAV 557
Query: 343 QLLRTLQGTVSQAQERVQLQMAE--LVTTHKCLHHEVKRLNEENQGLRAE-QLPSSAPQ- 398
+ + T++G +++ QL+ L + E+++L EE L AE QL + Q
Sbjct: 558 RKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQ 617
Query: 399 --GSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEE 456
G +EQGE E +Q L Q+ LQ + L +++ R+ +E
Sbjct: 618 EVGRAREQGEAE---------RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 668
Query: 457 TVARASLEGQLRVQRE-ETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRL- 514
T ASL +L Q+E + L+ + + T + R Q ++ +L + E V+ L
Sbjct: 669 TEEAASLRQELTQQQELYGQALQEKVAEVETRL-REQLSDTERRLNEARREHAKAVVSLR 727
Query: 515 QAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
Q + +++ +R SQ L+ E R+ E R + +
Sbjct: 728 QIQRRAAQEKER-----SQELRRLQEEARKEEGQRLARRLQE 764
Score = 42.4 bits (98), Expect = 0.001
Identities = 121/576 (21%), Positives = 227/576 (39%), Gaps = 76/576 (13%)
Query: 7 VAADDDERRRRPGA-ALEDSR--SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEV 63
V++D E RR + LE S+ SQ+ + EL RL E+ L E + +
Sbjct: 154 VSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVR-LLRETSLQQKMRLE 212
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+++ + EA+A ++ + E L+A L + + R+ ++ + + E+
Sbjct: 213 AQAMELEALARAEKAGRAEAEGLRAALAGA-----------EVVRKNLEEGSQRELEEVQ 261
Query: 124 RLKQLLSRAYPLDSLEKQMEKAHEDS-EKLREIVLPMEKEIEELKAKLLRAEELIQEIQR 182
RL Q L SL + AHE++ L +EK + L+ + RA E +E+
Sbjct: 262 RLHQ-----EQLSSLTQ----AHEEALSSLTSKAEGLEKSLSSLETR--RAGEA-KELAE 309
Query: 183 RPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
R A L +L D + +E L G + H+ ++ L
Sbjct: 310 AQREAELLR--KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWEL--- 357
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
L ++ Q L QE+ SL +T L+ + + Q E+L R++
Sbjct: 358 --ERQKLLETMQHL---QEDRDSLHATAELLQVRVQ----SLTHILALQEEELT---RKV 405
Query: 303 QKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQ 362
Q + Q L R E M L AQ ++ L+G V+ QE+V Q
Sbjct: 406 QPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ 465
Query: 363 MAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLC 422
E + L + + E G + QL S Q +++ ++ +S E +L+
Sbjct: 466 SQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ---TASAEEQLRLVV 522
Query: 423 CTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEG------QLRVQREETEV 476
++ L+ E ++ +L L ++ G L R+E+
Sbjct: 523 NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP 582
Query: 477 LEASLCSLRTEMERVQQEQSK----AQLPDLLSEQRAKVLRLQAELE------TSEQVQR 526
L + + E++++++E+++ QL L +Q R Q E E ++Q+++
Sbjct: 583 LPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQ 642
Query: 527 DFVRLSQA-----LQVRLERIRQAETLEQVRSIMDE 557
+ + ++ LQ+ + R Q E+ E+ S+ E
Sbjct: 643 ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 678
>gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2
[Homo sapiens]
Length = 835
Score = 76.3 bits (186), Expect = 7e-14
Identities = 132/582 (22%), Positives = 237/582 (40%), Gaps = 64/582 (10%)
Query: 22 LEDSRSQEGANGEAESGELSRL-RAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
L ++ Q+ EA++ EL L RAE AG AE E ++A +E + QR+ +
Sbjct: 164 LRETSLQQKMRLEAQAMELEALARAEKAGR-AEAEGLRAALAGAEVVRKNLEEGSQRELE 222
Query: 81 EEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKE-RELGRLKQLLSRAYPLDSLE 139
E Q L ++E +++L + + ++ E R G K+L + L
Sbjct: 223 EVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLR 282
Query: 140 KQMEKAHEDSEKLREIVLPMEKEI-EELKAKL------LRAEELIQEIQRRPRHAPSLHG 192
KQ+ K ED E +V + K + E++ +++ L ++L++ +Q SLH
Sbjct: 283 KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHA 342
Query: 193 STELLPLSRDPSPPLEPL--EELSGDGGPAAEA---FAHNCDD----------------- 230
+ ELL + + L EEL+ P+ F C
Sbjct: 343 TAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLK 402
Query: 231 ----SASISSFSLGGGVGSS----SSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
S S L G V S +S Q + L ++ A+ V + +G+ L
Sbjct: 403 AQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELS 462
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q +Q + QL+ + +VS + L+ + + E A Q+ L ++ +
Sbjct: 463 RAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKV-EGAAAQLPSLNNRLSYAV 521
Query: 343 QLLRTLQGTVSQAQERVQLQMAE--LVTTHKCLHHEVKRLNEENQGLRAE-QLPSSAPQ- 398
+ + T++G +++ QL+ L + E+++L EE L AE QL + Q
Sbjct: 522 RKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQ 581
Query: 399 --GSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEE 456
G +EQGE E +Q L Q+ LQ + L +++ R+ +E
Sbjct: 582 EVGRAREQGEAE---------RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 632
Query: 457 TVARASLEGQLRVQRE-ETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRL- 514
T ASL +L Q+E + L+ + + T + R Q ++ +L + E V+ L
Sbjct: 633 TEEAASLRQELTQQQELYGQALQEKVAEVETRL-REQLSDTERRLNEARREHAKAVVSLR 691
Query: 515 QAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
Q + +++ +R SQ L+ E R+ E R + +
Sbjct: 692 QIQRRAAQEKER-----SQELRRLQEEARKEEGQRLARRLQE 728
Score = 42.4 bits (98), Expect = 0.001
Identities = 121/576 (21%), Positives = 227/576 (39%), Gaps = 76/576 (13%)
Query: 7 VAADDDERRRRPGA-ALEDSR--SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEV 63
V++D E RR + LE S+ SQ+ + EL RL E+ L E + +
Sbjct: 118 VSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVR-LLRETSLQQKMRLE 176
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+++ + EA+A ++ + E L+A L + + R+ ++ + + E+
Sbjct: 177 AQAMELEALARAEKAGRAEAEGLRAALAGA-----------EVVRKNLEEGSQRELEEVQ 225
Query: 124 RLKQLLSRAYPLDSLEKQMEKAHEDS-EKLREIVLPMEKEIEELKAKLLRAEELIQEIQR 182
RL Q L SL + AHE++ L +EK + L+ + RA E +E+
Sbjct: 226 RLHQ-----EQLSSLTQ----AHEEALSSLTSKAEGLEKSLSSLETR--RAGEA-KELAE 273
Query: 183 RPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
R A L +L D + +E L G + H+ ++ L
Sbjct: 274 AQREAELLR--KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWEL--- 321
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
L ++ Q L QE+ SL +T L+ + + Q E+L R++
Sbjct: 322 --ERQKLLETMQHL---QEDRDSLHATAELLQVRVQ----SLTHILALQEEELT---RKV 369
Query: 303 QKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQ 362
Q + Q L R E M L AQ ++ L+G V+ QE+V Q
Sbjct: 370 QPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ 429
Query: 363 MAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLC 422
E + L + + E G + QL S Q +++ ++ +S E +L+
Sbjct: 430 SQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ---TASAEEQLRLVV 486
Query: 423 CTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEG------QLRVQREETEV 476
++ L+ E ++ +L L ++ G L R+E+
Sbjct: 487 NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP 546
Query: 477 LEASLCSLRTEMERVQQEQSK----AQLPDLLSEQRAKVLRLQAELE------TSEQVQR 526
L + + E++++++E+++ QL L +Q R Q E E ++Q+++
Sbjct: 547 LPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQ 606
Query: 527 DFVRLSQA-----LQVRLERIRQAETLEQVRSIMDE 557
+ + ++ LQ+ + R Q E+ E+ S+ E
Sbjct: 607 ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
>gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3
[Homo sapiens]
Length = 782
Score = 76.3 bits (186), Expect = 7e-14
Identities = 132/582 (22%), Positives = 237/582 (40%), Gaps = 64/582 (10%)
Query: 22 LEDSRSQEGANGEAESGELSRL-RAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
L ++ Q+ EA++ EL L RAE AG AE E ++A +E + QR+ +
Sbjct: 111 LRETSLQQKMRLEAQAMELEALARAEKAGR-AEAEGLRAALAGAEVVRKNLEEGSQRELE 169
Query: 81 EEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKE-RELGRLKQLLSRAYPLDSLE 139
E Q L ++E +++L + + ++ E R G K+L + L
Sbjct: 170 EVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLR 229
Query: 140 KQMEKAHEDSEKLREIVLPMEKEI-EELKAKL------LRAEELIQEIQRRPRHAPSLHG 192
KQ+ K ED E +V + K + E++ +++ L ++L++ +Q SLH
Sbjct: 230 KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHA 289
Query: 193 STELLPLSRDPSPPLEPL--EELSGDGGPAAEA---FAHNCDD----------------- 230
+ ELL + + L EEL+ P+ F C
Sbjct: 290 TAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLK 349
Query: 231 ----SASISSFSLGGGVGSS----SSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPP 282
S S L G V S +S Q + L ++ A+ V + +G+ L
Sbjct: 350 AQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELS 409
Query: 283 GYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSE 342
Q +Q + QL+ + +VS + L+ + + E A Q+ L ++ +
Sbjct: 410 RAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKV-EGAAAQLPSLNNRLSYAV 468
Query: 343 QLLRTLQGTVSQAQERVQLQMAE--LVTTHKCLHHEVKRLNEENQGLRAE-QLPSSAPQ- 398
+ + T++G +++ QL+ L + E+++L EE L AE QL + Q
Sbjct: 469 RKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQ 528
Query: 399 --GSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEE 456
G +EQGE E +Q L Q+ LQ + L +++ R+ +E
Sbjct: 529 EVGRAREQGEAE---------RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 579
Query: 457 TVARASLEGQLRVQRE-ETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRL- 514
T ASL +L Q+E + L+ + + T + R Q ++ +L + E V+ L
Sbjct: 580 TEEAASLRQELTQQQELYGQALQEKVAEVETRL-REQLSDTERRLNEARREHAKAVVSLR 638
Query: 515 QAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMD 556
Q + +++ +R SQ L+ E R+ E R + +
Sbjct: 639 QIQRRAAQEKER-----SQELRRLQEEARKEEGQRLARRLQE 675
Score = 42.4 bits (98), Expect = 0.001
Identities = 121/576 (21%), Positives = 227/576 (39%), Gaps = 76/576 (13%)
Query: 7 VAADDDERRRRPGA-ALEDSR--SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEV 63
V++D E RR + LE S+ SQ+ + EL RL E+ L E + +
Sbjct: 65 VSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVR-LLRETSLQQKMRLE 123
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+++ + EA+A ++ + E L+A L + + R+ ++ + + E+
Sbjct: 124 AQAMELEALARAEKAGRAEAEGLRAALAGA-----------EVVRKNLEEGSQRELEEVQ 172
Query: 124 RLKQLLSRAYPLDSLEKQMEKAHEDS-EKLREIVLPMEKEIEELKAKLLRAEELIQEIQR 182
RL Q L SL + AHE++ L +EK + L+ + RA E +E+
Sbjct: 173 RLHQ-----EQLSSLTQ----AHEEALSSLTSKAEGLEKSLSSLETR--RAGEA-KELAE 220
Query: 183 RPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
R A L +L D + +E L G + H+ ++ L
Sbjct: 221 AQREAELLR--KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWEL--- 268
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
L ++ Q L QE+ SL +T L+ + + Q E+L R++
Sbjct: 269 --ERQKLLETMQHL---QEDRDSLHATAELLQVRVQ----SLTHILALQEEELT---RKV 316
Query: 303 QKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQ 362
Q + Q L R E M L AQ ++ L+G V+ QE+V Q
Sbjct: 317 QPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ 376
Query: 363 MAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLC 422
E + L + + E G + QL S Q +++ ++ +S E +L+
Sbjct: 377 SQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ---TASAEEQLRLVV 433
Query: 423 CTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEG------QLRVQREETEV 476
++ L+ E ++ +L L ++ G L R+E+
Sbjct: 434 NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP 493
Query: 477 LEASLCSLRTEMERVQQEQSK----AQLPDLLSEQRAKVLRLQAELE------TSEQVQR 526
L + + E++++++E+++ QL L +Q R Q E E ++Q+++
Sbjct: 494 LPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQ 553
Query: 527 DFVRLSQA-----LQVRLERIRQAETLEQVRSIMDE 557
+ + ++ LQ+ + R Q E+ E+ S+ E
Sbjct: 554 ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 589
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 75.9 bits (185), Expect = 9e-14
Identities = 123/553 (22%), Positives = 225/553 (40%), Gaps = 80/553 (14%)
Query: 4 AAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEV 63
AA +AA++ + + R LE R Q+ A AE G + +L+ + ++++
Sbjct: 422 AATLAANNTQLQARV-EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS------- 473
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
S S ++A +++ Q A L A ++S +++T L QQQ Q EL
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTA----QVASLTSELTTLNATIQQQDQ-------ELA 522
Query: 124 RLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQR- 182
LKQ L + +++ + S+ LR ++E+L + L + E+ ++E+
Sbjct: 523 GLKQQAKEKQA--QLAQTLQQQEQASQGLRH-------QVEQLSSSLKQKEQQLKEVAEK 573
Query: 183 ----RPRHAPSLHGSTELLPLS-RDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSF 237
R HA L + E S R+ L+ LE L + E +++
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEIL----QQQLQVANE 629
Query: 238 SLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQT 297
+ S + + + LS + EE + V T +L QL++
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL-------QLRS 682
Query: 298 EGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQE 357
E +Q + E V++E+D+LQE L+ E L + + + L Q +S+
Sbjct: 683 E-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE--- 738
Query: 358 RVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESL------- 410
++ + LV HK E K L EE G + L + Q + Q E E L
Sbjct: 739 -LKAETRSLVEQHK---RERKELEEERAGRKG--LEARLQQLGEAHQAETEVLRRELAEA 792
Query: 411 -------PSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALE--------- 454
S +L + + R+ Q + + +++TL+E E
Sbjct: 793 MAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA 852
Query: 455 EETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQ-LPDLLSEQRAKVLR 513
+E VA +L++ R++ E+ E +L +++VQ+++ +AQ L D LS + K+
Sbjct: 853 KEKVAGIESHSELQISRQQNELAELH-ANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911
Query: 514 LQAELETSEQVQR 526
E+ E + R
Sbjct: 912 TSKEVARLETLVR 924
Score = 68.2 bits (165), Expect = 2e-11
Identities = 123/567 (21%), Positives = 220/567 (38%), Gaps = 83/567 (14%)
Query: 20 AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQC 79
A + R +A +L L E A L ++ VA + + +V QR+
Sbjct: 586 ATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
Query: 80 QE---EVASLQAILKDSISSY---EAQITALKQERQQQQQDCEEKERELGRLKQLLSRAY 133
E +V LQA ++ + +AQ+ L+ + + +QQ EKER QL +
Sbjct: 646 AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQ 705
Query: 134 PL-DSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHG 192
L +SL+ E+ + + + ++ I ELKA+ L+++ +R +
Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE---TRSLVEQHKRERKELEEERA 762
Query: 193 STE-----LLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSS 247
+ L L E L + A C+
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVK-------------- 808
Query: 248 SLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLE 307
+ R+ Q+E A G + E + T E+ + ++LQ+ E
Sbjct: 809 EVAAWRERYEDSQQEEAQY---GAMFQEQLM-----------TLKEECEKARQELQEAKE 854
Query: 308 SVSRERDELQEGLRRSNEDCAK---QMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMA 364
V+ + + R + A+ + L QVQ E + L +S QE++
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
Query: 365 ELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCT 424
E+ L V++ E+ + E + A G +Q P + E Q C+
Sbjct: 915 EVAR----LETLVRKAGEQQETASRELVKEPARAGDRQ--------PEWLEEQQGRQFCS 962
Query: 425 RQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSL 484
Q A LQA E AE++ E+ LR AL E +GQ + +R + E
Sbjct: 963 TQAA---LQAMEREAEQMGNELERLRAALMES-------QGQQQEERGQQE--------- 1003
Query: 485 RTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQR-DFVRLSQALQVRL-ERI 542
E+ R+ QE+ +AQ DL E+ A+ L+ L+ + QR +F L +AL L E+
Sbjct: 1004 -REVARLTQERGRAQ-ADLALEKAARA-ELEMRLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 543 RQAETLEQVRSIMDEAPLTDVRDIKDT 569
+ + L ++R ++ A + ++ +++ T
Sbjct: 1061 GKDQELAKLRG-LEAAQIKELEELRQT 1086
Score = 67.8 bits (164), Expect = 3e-11
Identities = 134/581 (23%), Positives = 234/581 (40%), Gaps = 69/581 (11%)
Query: 7 VAADDDERRRRPGAALEDSRSQE--GANGEAESGELSRLRAELAGALAEMETMKAVAEVS 64
+A + E GA E + E G EA E+S+L + + ++++ E
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 65 ESTKAE---AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERE 121
+++AE A+ +Q Q +E+ L + +++S + ++ A + + Q + +E + +
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQEL-GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQ 1212
Query: 122 LGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
+ R +Q R +SL +E E+ L VL E E +ELK ++ E Q+++
Sbjct: 1213 VARGRQEAERK---NSLISSLE---EEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266
Query: 182 RRPR--HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL 239
R R A + S S ++ L E + A+E A + L
Sbjct: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE-EL 1325
Query: 240 GGGVGS-SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE 298
G + + Q Q LS Q E S T LV E + P L Q EQ E
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLEHTS---TQALVSELL----PAKHLCQQLQAEQAAAE 1378
Query: 299 GRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQER 358
R R+EL++ ++ A ++ L + Q L L+ V++ +
Sbjct: 1379 -----------KRHREELEQ-----SKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422
Query: 359 VQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQ 418
Q AE K + E + ++ GL AE+ + + Q E L + +
Sbjct: 1423 AQQLRAE-----KASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477
Query: 419 QLLCCTRQEARARLQAQEHGA--------------ERLRIEIVTLREALEEETVARASLE 464
Q L R +A RL + A E +++++ R+ +EE +
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
Query: 465 GQLRV-QREETEVLEASLCSLRT--EMERVQQEQSKA-QLPDLLSEQRAKVLR-----LQ 515
QL V QRE+T+ +E L + +VQQ++ KA Q S+Q A+ L+ LQ
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
Query: 516 AELETSEQVQRDFVRLSQALQVRLERIRQ--AETLEQVRSI 554
A+L EQ + + + + +Q E EQ+RS+
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL 1638
Score = 67.8 bits (164), Expect = 3e-11
Identities = 107/531 (20%), Positives = 226/531 (42%), Gaps = 71/531 (13%)
Query: 39 ELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYE 98
E+S L ++ E + +K + ++ES K++ + R Q E AS A + S+
Sbjct: 1233 EVSILNRQVLEKEGESKELKRLV-MAESEKSQKLEERLRLLQAETASNSARAAERSSALR 1291
Query: 99 AQITALKQERQQQQQDCE----------EKERELGR-LKQLLSRAYPLDSLEKQMEKAHE 147
++ +L++E ++Q+ E E+ ELG+ LK + + + ++ H
Sbjct: 1292 EEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHT 1351
Query: 148 DSEKLREIVLPMEKEIEELKAKLLRAEELI-QEIQRRPRHAPSLHGSTELLPLSRDPSPP 206
++ L +LP + ++L+A+ AE+ +E+++ + A L ELL R+
Sbjct: 1352 STQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA--ELLRAQRELGEL 1409
Query: 207 LEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASL 266
+ ++++ A + A + +S G+ L + +GL E A+L
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL-----LAEENRGLG----ERANL 1460
Query: 267 VSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNED 326
G Q + +L + ++L +V + + ++R +
Sbjct: 1461 ----------------GRQFLE----VELDQAREKYVQELAAVRADAETRLAEVQREAQS 1500
Query: 327 CAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEV----KRLNE 382
A++++V+ A+ + ++ + + + ++++ Q+ +L + +V K+L +
Sbjct: 1501 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560
Query: 383 ENQGLRAEQ--LPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAE 440
+Q + +Q L + QG + +Q E + L + + ELQ A+L +E AE
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQ-EAQRLQAQLNELQ-----------AQLSQKEQAAE 1608
Query: 441 RLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQL 500
++++ + + + L+ QLR E L+ LR E ER+ E +A L
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAERLGHELQQAGL 1664
Query: 501 PDLLSEQ-----RAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAE 546
+EQ A+V L+A++ ++Q RD + A R QA+
Sbjct: 1665 KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAK 1715
Score = 66.6 bits (161), Expect = 6e-11
Identities = 117/557 (21%), Positives = 219/557 (39%), Gaps = 62/557 (11%)
Query: 20 AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMK-AVAEVSES-TKAEAVAAVQR 77
A L+++ + E + EL++LR A + E+E ++ V ++ E K E A
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Query: 78 QCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKEREL-GRLKQLLSRAYPLD 136
Q E A + + A+++ L+Q+ Q+QQ+ + ER L R L+
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKL---LRAEELIQEIQRRPRHAPSLHGS 193
+L+ Q+E+ ++ + + ++E+ + K+ +AE+ + R R S
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225
Query: 194 TELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSR 253
+ L + S + E G+ + S + ++S+ ++
Sbjct: 1226 L-ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 254 QGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRER 313
+ S +EE SL + E+ + L+++L S +
Sbjct: 1285 ERSSALREEVQSL----------------------REEAEKQRVASENLRQELTSQAERA 1322
Query: 314 DELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCL 373
+EL + L+ E ++ Q L+ +Q + L + A+ Q AE K
Sbjct: 1323 EELGQELKAWQEKFFQKEQA-LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 374 HHEVKRLNEENQGLRAEQLPSSAPQG---------------SQQEQGEEESLPSSVPELQ 418
E+++ + GLRAE L + G +QQ + E+ S + L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 419 QLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVA-RASLEGQL-RVQRE---- 472
+ +E R + G + L +E+ RE +E A RA E +L VQRE
Sbjct: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQST 1501
Query: 473 --ETEVL----EASLCSLRTEMERVQQEQSK-----AQLPDLLSEQRAKVLRLQAELETS 521
E EV+ E + + E +R Q+E+ K QL EQ +V L +L S
Sbjct: 1502 ARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Query: 522 EQVQRDFVRLSQALQVR 538
+Q + + +A+Q +
Sbjct: 1562 DQASKVQQQKLKAVQAQ 1578
Score = 65.9 bits (159), Expect = 1e-10
Identities = 127/565 (22%), Positives = 240/565 (42%), Gaps = 58/565 (10%)
Query: 36 ESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEV---ASLQ--AIL 90
E+G+LS E A L +++ A+ E++E +++Q Q E A+LQ L
Sbjct: 319 ENGDLSFKLREFASHLQQLQD--ALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 91 KDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSE 150
++ + +++ L++ Q Q + +++ E+ L L++L+++ ++
Sbjct: 377 EEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV------LGDVLQLETLKQEAATLAANNT 430
Query: 151 KLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPL 210
+L+ V +E E + +AKLL +E +++ SL T+L + S E L
Sbjct: 431 QLQARVEMLETERGQQEAKLLAERGHFEEEKQQ---LSSL--ITDLQSSISNLSQAKEEL 485
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLG------GGVGSSSSLPQSRQGLSPEQEETA 264
E+ S G A + + + ++ G+ + Q++ + +Q+E A
Sbjct: 486 EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
Query: 265 SLVSTGTLVPEGIYLPPPGYQL--VPDTQWEQLQTEGRQLQ---KDLESVSRERDELQEG 319
S + L QL V + Q Q +QL ++ E+ RERD +
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ 605
Query: 320 LRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQ-ERVQL-----QMAELVTTHKCL 373
L ++ A ++++L Q+Q + + + Q +V+QAQ E+ +L ++ V T +
Sbjct: 606 LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 374 HHEVK-RLNEENQGLRAEQLPSSAPQGSQQE----QGEEESLPSSVPELQQLLCCTRQEA 428
HE + ++ E LR+EQ ++ + QE Q + ++L S+ + L ++ A
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
Query: 429 RARLQAQEHGAERLRIEIVTL-------REALEEETVARASLEGQLR----VQREETEVL 477
L+ Q+ L+ E +L R+ LEEE R LE +L+ + ETEVL
Sbjct: 726 ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
Query: 478 EASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQV 537
L Q ++++ L+ E A R + + Q F L+
Sbjct: 786 RRELAE-----AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 840
Query: 538 RLERIRQ--AETLEQVRSIMDEAPL 560
E+ RQ E E+V I + L
Sbjct: 841 ECEKARQELQEAKEKVAGIESHSEL 865
Score = 62.0 bits (149), Expect = 1e-09
Identities = 125/582 (21%), Positives = 235/582 (40%), Gaps = 101/582 (17%)
Query: 24 DSRSQEGANGEAESGELSRLRAELAGAL--AEMETMKAVAEVSE-----------STKAE 70
DS + E ELSR EL + A E +A A+V+E +T+ E
Sbjct: 632 DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDC-----------EEKE 119
VA + Q QE++ +L+ LK + S E + ++QQ+ E+ +
Sbjct: 692 RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
Query: 120 RELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKL--REIVLPM------EKEIEELKAKLL 171
RE L++ + L++ +Q+ +AH+ ++ RE+ M E E E+L ++
Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Query: 172 RAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDS 231
E ++ Q+ ++ +L+ L + + L+E A E A
Sbjct: 812 AWRERYEDSQQEEAQYGAMF-QEQLMTLKEECEKARQELQE-------AKEKVA------ 857
Query: 232 ASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQ 291
G+ S S L SRQ Q E A L + + + + +
Sbjct: 858 ----------GIESHSELQISRQ-----QNELAELHANLARALQQVQ--------EKEVR 894
Query: 292 WEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGT 351
++L + LQ+ + + S+E L+ +R++ E + L+ ++ R
Sbjct: 895 AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV------KEPARAGDRQ 948
Query: 352 VSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLP 411
+E+ Q + + E +++ E + LRA + S Q Q+E+G++E
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ--QEERGQQEREV 1006
Query: 412 SSVPELQ---QLLCCTRQEARARLQAQ-EHGAERLRIEIVTLREAL-------EEETVAR 460
+ + + + Q + ARA L+ + ++ R+E TL+EAL E +
Sbjct: 1007 ARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQEL 1066
Query: 461 ASLEGQLRVQREETEVLEASLCSLRTEMERVQQE-------QSKA-----QLPDLLSEQR 508
A L G Q +E E L ++ L+ ++ + ++E QS+A L R
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
Query: 509 AKVLRLQAELETSEQVQRDFVRLSQALQV-RLERIRQAETLE 549
A+V +L+ + + ++ R +A + R ER ETL+
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168
Score = 39.7 bits (91), Expect = 0.008
Identities = 44/196 (22%), Positives = 88/196 (44%), Gaps = 35/196 (17%)
Query: 46 ELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKD----------SIS 95
EL+ LA+ + V + K +AV A + Q+E LQA L + +
Sbjct: 1553 ELSKKLADSDQASKV----QQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608
Query: 96 SYEAQITALK---QERQQQQQDCEEKERELGRL----KQLLSRAYPLDSLEKQMEKAHED 148
Y+ Q+ K ++QQ Q+ +E+ R L +L K+L + A + L ++++A
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA---ERLGHELQQAGLK 1665
Query: 149 SEKLREIVLPMEKEIEELKAKLLRAEELIQEI-----------QRRPRHAPSLHGSTELL 197
+++ + + ++ L+A++ A++ ++++ R P+ P L S + L
Sbjct: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSL 1725
Query: 198 PLSRDPSPPLEPLEEL 213
LS + PL +L
Sbjct: 1726 DLSCEEGTPLSITSKL 1741
Score = 35.4 bits (80), Expect = 0.14
Identities = 40/155 (25%), Positives = 74/155 (47%), Gaps = 18/155 (11%)
Query: 34 EAESGELSRLRAELAGALAEM--ETMKAVAEVSEST-KAEAVAAVQRQCQEEVASLQAIL 90
++ + EL + A+ GA ++ E + E + T + E + QR+ ++V L L
Sbjct: 1499 QSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKL 1558
Query: 91 KDSISSYEAQITALKQERQQ---QQQDCEEKERELGRLK-QLLSRAYPLDSLEKQMEKA- 145
DS + + Q LK + Q QQ+ + + +L L+ QL + + + QMEKA
Sbjct: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAK 1618
Query: 146 -HEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
H D++K ++ +EL+ +L E+L +E
Sbjct: 1619 THYDAKK---------QQNQELQEQLRSLEQLQKE 1644
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 75.5 bits (184), Expect = 1e-13
Identities = 136/591 (23%), Positives = 227/591 (38%), Gaps = 67/591 (11%)
Query: 16 RRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAV 75
RR AL D + EA++ E +RL ELA A AE +AEA A
Sbjct: 738 RRKAEALGDELEAQARKLEAQNTEAARLSKELAQARR--------AEAEAHREAEAQAWE 789
Query: 76 QRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPL 135
Q + +E V + L+ + EA + AL ++++Q E R + + R L
Sbjct: 790 QARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVL 849
Query: 136 DSLEKQ-MEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGST 194
+S +Q +E+A + + + +EK + K R E L +E+++
Sbjct: 850 ESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQ------ 903
Query: 195 ELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQ 254
E L + LE+ AA + L + L Q
Sbjct: 904 EFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEEL---FQLRQGPA 960
Query: 255 GLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERD 314
GL P++ LV T + I + LV + LQ + + L+ L S+
Sbjct: 961 GLGPKKRAEPQLVETQNV--RLIEVERSNAMLVAEKA--ALQGQLQHLEGQLGSLQGRAQ 1016
Query: 315 ELQEGLRRSNEDCAK---QMQVLLAQVQNSEQLLRTLQGTVS---QAQERVQLQMAELVT 368
EL +R+ E ++ + VL Q Q + L L+ V Q+QE + Q L+
Sbjct: 1017 ELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLR 1076
Query: 369 THKCLHHEVKRLNEENQGLRAEQLPSSAPQGS-----QQEQGEEESLPS---SVPELQQL 420
HK L +R E +GL A + ++ QG E L + SV +
Sbjct: 1077 DHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVA 1136
Query: 421 LCCTRQ-------------EARARLQAQEHGAERLRIEIVTLREALEEET---------- 457
L R+ E RLQ++ A+ L E+ R L+ E
Sbjct: 1137 LLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARL 1196
Query: 458 -VARASLEGQLRVQREETEVLEASLCSLRTE------MERVQQEQSKAQLPDLLSEQRAK 510
+ RA LE Q + RE + L+ S C L T+ + Q+E+++ L ++ + R
Sbjct: 1197 ELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSREN 1256
Query: 511 VLRLQAELETSEQVQRDFVR-LSQALQVRLERIRQAETLEQVRSIMDEAPL 560
L+ LE+ + + R+ L Q +R E+ + E + +++ PL
Sbjct: 1257 RELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPL 1307
Score = 47.8 bits (112), Expect = 3e-05
Identities = 140/604 (23%), Positives = 231/604 (38%), Gaps = 116/604 (19%)
Query: 39 ELSRLRAELAGA------LAEMETMKAVAEVSESTKAEAVAAVQRQCQE--EVASLQAIL 90
EL R R L A L E + V E S++ E + A + +C E +L
Sbjct: 335 ELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLL 394
Query: 91 KDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQL---------LSRAYPLDSLEKQ 141
+ + A++ +L+ + Q ++ E E EL R + L+ A P SL+ +
Sbjct: 395 RTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAP--SLQDE 452
Query: 142 MEKAHEDSEKLREIVLPMEKEIEELKAKL--LRAEELIQE-IQRRPRHAPSLHGSTEL-- 196
+ +A ++ +LR + E+E EL+ L L+ + Q + PR P L E
Sbjct: 453 VREA--EAGRLRTL----ERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQ 506
Query: 197 LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSS---SSLPQSR 253
P++ D SP + L + + DGGP A A DS +S S + P
Sbjct: 507 TPVAFDHSP--QGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQA 564
Query: 254 QGLSPEQ-----EETASLVST----------GTLVPEGIYLPPPGYQLVPDTQWEQLQ-- 296
+ P+ +E+ S V T +L PP G P T+ + Q
Sbjct: 565 AAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQG----PGTKIQAPQLL 620
Query: 297 ---TEGRQ-----LQKDLESVSRERDELQEG------LRRSNEDCAKQMQVLLAQVQNSE 342
TEGR+ L + + +E E + G ++ ++ Q L +
Sbjct: 621 GGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR 680
Query: 343 QLLRTLQGTV-----------SQAQERVQL--------QMAELVTTHKCLHHEVKRLNEE 383
+ + L+GTV S+ VQ+ +A V + L EV +L +
Sbjct: 681 EHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRK 740
Query: 384 NQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLR 443
+ L ++L + A + Q E L + + ++ EA +AQ RLR
Sbjct: 741 AEAL-GDELEAQARKLEAQNT-EAARLSKELAQARR----AEAEAHREAEAQAWEQARLR 794
Query: 444 IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME------RVQQEQSK 497
+ + LE + R +L L E E LR + E +V + + +
Sbjct: 795 EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGR 854
Query: 498 AQLPDLLSEQRAKVLRLQAELETS-----------EQVQRDFVRLSQALQVRLERIRQAE 546
L + E+R K LQAELE + E +QR+ L QA R E +R+ E
Sbjct: 855 QHLEEAERERREKE-ALQAELEKAVVRGKELGARLEHLQRE---LEQAALERQEFLREKE 910
Query: 547 TLEQ 550
+ Q
Sbjct: 911 SQHQ 914
Score = 45.1 bits (105), Expect = 2e-04
Identities = 92/424 (21%), Positives = 158/424 (37%), Gaps = 73/424 (17%)
Query: 14 RRRRPGAALEDSR--SQEGANGEAESGELSRLRAELAGA-------LAEMET--MKAVAE 62
+R AALE ++ + + G RL AEL A L E++T ++ E
Sbjct: 892 QRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEE 951
Query: 63 VSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKEREL 122
+ + + A +++ + ++ Q + + A + A K Q Q Q E
Sbjct: 952 LFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLE------ 1005
Query: 123 GRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQR 182
G+L L RA L Q ++A E S +L+ +E + +EL KL E L +E++
Sbjct: 1006 GQLGSLQGRA---QELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKL---EVLEEEVRA 1059
Query: 183 RPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
+ G + L L+ +E +G + D A++ + L
Sbjct: 1060 ARQSQEETRGQQQALLRDHKALAQLQRRQEAELEG-----LLVRHRDLKANMRALELAHR 1114
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
Q S E +E A L L+ +G Q + + +LQ+E +
Sbjct: 1115 ELQGRHEQLQAQRASVEAQEVALLAERERLMQDG------HRQRGLEEELRRLQSEHDRA 1168
Query: 303 QKDLESVSRERDELQ------------------------EGLRRSNED-----------C 327
Q L +SRER ELQ + LR SN+ C
Sbjct: 1169 QMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQC 1228
Query: 328 AKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGL 387
Q+ AQ + + QLL +Q + +E ++ + + LH E + ++ L
Sbjct: 1229 ELLTQLRSAQEEENRQLLAEVQALSRENRELLERSL----ESRDHLHREQREYLDQLNAL 1284
Query: 388 RAEQ 391
R E+
Sbjct: 1285 RREK 1288
Score = 33.5 bits (75), Expect = 0.54
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 48/263 (18%)
Query: 324 NEDCAKQMQVLL-------AQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
+E+ +Q++ +L Q ++ E +R +QG + Q + + E+ +
Sbjct: 129 SEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGV--- 185
Query: 377 VKRLNEENQGLRAE---QLPSSAPQGSQQEQGEEESLPSSVPELQQLLC-----CTRQEA 428
V L+ + G A ++ S + G+ + E L + L +LL C R EA
Sbjct: 186 VLALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQ--RLAELLLEREPLCLRPEA 243
Query: 429 RARLQAQ---EHGA----------ERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+R A+ H A RLR E+ E L + LE ++R R+E +
Sbjct: 244 PSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQ 303
Query: 476 VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQAL 535
L + R E+ R + E L E+ ++ RLQ EL R+ ++ ++A
Sbjct: 304 ALSGQ--AKRAELYREEAE--------ALRERAGRLPRLQEELRRC----RERLQAAEAY 349
Query: 536 QVRLERIR-QAETLEQVRSIMDE 557
+ +LE R + LE +++++E
Sbjct: 350 KSQLEEERVLSGVLEASKALLEE 372
Score = 30.4 bits (67), Expect = 4.6
Identities = 26/103 (25%), Positives = 44/103 (42%), Gaps = 1/103 (0%)
Query: 77 RQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLD 136
RQ EE A L + + EA+I L+QE Q + E + L RA L
Sbjct: 271 RQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLP 330
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
L++++ + E + +E+E L L ++ L++E
Sbjct: 331 RLQEELRRCRERLQAAEAYKSQLEEE-RVLSGVLEASKALLEE 372
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 74.7 bits (182), Expect = 2e-13
Identities = 116/528 (21%), Positives = 224/528 (42%), Gaps = 79/528 (14%)
Query: 51 LAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQA----------ILKDSISSYEAQ 100
L E E + + E E + +Q++ + E ASL +L+++ S + +
Sbjct: 1028 LVEQEVQEKLRETQEYNR------IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE 1081
Query: 101 ITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPME 160
++AL+Q+ Q+ Q + +E ++ L+Q + EK+ + ++++ L E+
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQMELLRQ--------EVKEKEADFLAQEAQLLEELEASHI 1133
Query: 161 KEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPA 220
E ++L+A L E ++Q R R S E L + P + +L+
Sbjct: 1134 TE-QQLRASLWAQEAKAAQLQLRLR---STESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 221 AEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLP 280
+A C+ +S GGG S P S GL P+Q SL G L+
Sbjct: 1190 QQALGSVCESRPELS----GGG----DSAP-SVWGLEPDQNGARSLFKRGPLLTA----- 1235
Query: 281 PPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNE---DCAKQMQVLLAQ 337
E + + +L +DL + RD L++ +++ E D + + +
Sbjct: 1236 ---------LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE 1286
Query: 338 VQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAP 397
+Q+ ++ L Q S+ + + +EL+ H+ + RL RAE A
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR------RAELQRMEAQ 1340
Query: 398 QGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLR---EALE 454
+ Q +E+L + V LQ + EARA+ A E LR L+ E +E
Sbjct: 1341 GERELLQAAKENLTAQVEHLQAAVV----EARAQASAAGILEEDLRTARSALKLKNEEVE 1396
Query: 455 EETVARASLEGQLRVQREETEVLEASLCSL-RTEMERVQQ-EQSKAQLPDLLSEQRAKVL 512
E +L+ Q ++ + + L+ +L L +T ER ++ E + Q+ +L ++ +
Sbjct: 1397 SERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKA 1456
Query: 513 RLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPL 560
L E + D + +Q + ++ E+I++ LE+ RS+++ P+
Sbjct: 1457 AL-------ELLSLDLKKRNQEVDLQQEQIQE---LEKCRSVLEHLPM 1494
Score = 73.6 bits (179), Expect = 5e-13
Identities = 129/530 (24%), Positives = 207/530 (39%), Gaps = 89/530 (16%)
Query: 62 EVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDC------ 115
E T+ A+ + +E LQA I E+ T L +E Q++ Q+
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQA-QSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638
Query: 116 -EEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLL-RA 173
EE +R+ L Q L R L+K+ + ED + +L E+++E++K L R
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL--EEDLEQIKLSLRERG 1696
Query: 174 EELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSAS 233
EL + Q A G S+ LE ++ + D E + +
Sbjct: 1697 RELTTQRQLMQERAEEGKGP------SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 234 ISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWE 293
+ L Q QGL + ET+ L+S E + L +
Sbjct: 1751 LKD-----------QLEQQLQGLHRKVGETSLLLSQRE--QEIVVLQ------------Q 1785
Query: 294 QLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR----TLQ 349
QLQ Q + +S+ + DE Q L + +++ + +Q Q Q E+ ++ LQ
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL-EALQQEQQQAQGQEERVKEKADALQ 1844
Query: 350 GTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQ--------------GLRAEQ---- 391
G + QA ++ + EL HK + +RL EE LRAE
Sbjct: 1845 GALEQAHMTLKERHGEL-QDHK---EQARRLEEELAVEGRRVQALEEVLGDLRAESREQE 1900
Query: 392 -----LPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEA---RARLQAQEHGAERLR 443
L + +Q+ + E +L S + Q +L QE RA Q+ H E R
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 444 IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDL 503
L+EAL + A E L Q E + LEAS +L+ ++ Q
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH--------- 2011
Query: 504 LSEQRAKVLRLQ-AELETSE-QVQRDFVRLSQALQVRLERIRQAETLEQV 551
S Q + LR+Q E++ + + Q D +L QAL R E +R + EQ+
Sbjct: 2012 -SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL 2060
Score = 72.8 bits (177), Expect = 8e-13
Identities = 137/570 (24%), Positives = 232/570 (40%), Gaps = 110/570 (19%)
Query: 26 RSQE----GANGEAESGELSRLRAELAGALAE-----------METMKAVAEVSESTKAE 70
RSQE + G+ E EL EL+ L + ++ ++ E+ E+ E
Sbjct: 263 RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322
Query: 71 AV---AAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQ--QQDCEEKERELGRL 125
+ A++ R QEE SLQ ++KD IT + E Q E EL
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKD--------ITQVMVEEGDNIAQGSGHENSLELD-- 372
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEK----LREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
S+ Q + ++D++K +R ++ + +++L+ +L +E + +Q
Sbjct: 373 ----------SSIFSQFD--YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
Query: 182 RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGG 241
++ H E + + L++L+G+ D+ + + L G
Sbjct: 421 QQ-------HDQWE-----EEGKALRQRLQKLTGE------------RDTLAGQTVDLQG 456
Query: 242 GVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
V SL + R+ L +EE + L E L +L Q + Q + +
Sbjct: 457 EV---DSLSKERELLQKAREELRQQLE--VLEQEAWRLRRVNVEL--QLQGDSAQGQKEE 509
Query: 302 LQKDLESVSRERDELQE---GLRRSNEDCAKQMQVLLAQVQNSE---QLLRTLQGTVSQA 355
Q++L RER+ LQE GL + ++ L +++S +LLR Q V+ A
Sbjct: 510 QQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569
Query: 356 QERVQLQMAELVTTHKCLHHEVK-------RLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408
R + +AEL ++ L EV +L+ N+ L +++ Q Q + E +
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV--GLNQQLLQLEEENQ 627
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
S+ S + +Q R + L E E L + L L++ A A L+ LR
Sbjct: 628 SVCSRMEAAEQ----ARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528
+EE E ++ L R QQE + QL L E + R + L + Q +
Sbjct: 684 DIQEEKEEIQKKLSE-----SRHQQEAATTQLEQLHQEAK----RQEEVLARAVQEKEAL 734
Query: 529 VRLSQALQVRL---ERIRQ--AETLEQVRS 553
VR AL+VRL ER RQ AE L+ + S
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSS 764
Score = 72.4 bits (176), Expect = 1e-12
Identities = 124/567 (21%), Positives = 235/567 (41%), Gaps = 78/567 (13%)
Query: 43 LRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ-----EEVASLQAILKDSISSY 97
LR +LAG E + + + + + E A QR + + +A L+ + S
Sbjct: 405 LRQQLAGC---QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461
Query: 98 EAQITALKQERQQQQQDCEEKERELGRLKQL-----LSRAYPLDSLEKQMEKAH---EDS 149
+ L++ R++ +Q E E+E RL+++ L E+Q E+ H +
Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521
Query: 150 EKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSR-DPSPPLE 208
E+L+E+++ +E + E ++L+ E ++ S H ELL + + + L
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALE----------SSHLEGELLRQEQTEVTAALA 571
Query: 209 PLEELSGDGGPAAEAFAHNCDD--SASISSFSLGGGVGSSS-SLPQSRQGLSPEQEETAS 265
E+ + + D +A++ +L + L Q L E + S
Sbjct: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
Query: 266 LVSTGTLVPEGIYLPPPGYQLVPDTQWE-------QLQTE---GRQLQKDLESVSRERDE 315
+ + + + + WE QLQ G +LQ DL + E++E
Sbjct: 632 RMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEE 691
Query: 316 LQEGL---RRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKC 372
+Q+ L R E Q++ L + + E++L Q +E + + A L +
Sbjct: 692 IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL----ARAVQEKEALVREKAALEVRLQA 747
Query: 373 LHHEVKRLNEENQGLRA--EQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ + + L E+ QGL + E L SS + QQ E + ++Q T +A+
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ-----TVTQAKE 802
Query: 431 RLQAQEHGAERLRIEIVTLREALEEE------TVARASLEGQLRVQREETEVLEASLCSL 484
+Q + L++E+ T R E+E +A+A EG+ +++++ E + L
Sbjct: 803 VIQGE---VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA-AHEKEVNQL 858
Query: 485 RTEMERV----QQEQSKA---------QLPDLLSEQRAKVLRLQAELETSEQVQRDFVRL 531
R + E+ QQE +KA +L L EQ+ ++ +QA+ E E+ Q +
Sbjct: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-EERTQAESALC 917
Query: 532 SQALQVRLERIRQAETLEQVRSIMDEA 558
L+ ER+ ETL Q + + +A
Sbjct: 918 QMQLETEKERVSLLETLLQTQKELADA 944
Score = 71.2 bits (173), Expect = 2e-12
Identities = 121/470 (25%), Positives = 202/470 (42%), Gaps = 83/470 (17%)
Query: 99 AQITALKQERQQQQQDCEEKERELGRLK--------QLLSRAYPLDSLEKQMEKAHEDSE 150
AQ+ L + Q+ +++ E+ +EL +LK +L R L +L Q +K +ED E
Sbjct: 244 AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYE 303
Query: 151 KLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPL 210
K+ + + + +E +L+ E + S + E L L + + +
Sbjct: 304 KMIKALRETVEILETNHTELMEHEASL-----------SRNAQEEKLSLQQVIKDITQVM 352
Query: 211 EELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270
E +G A+ H S FS + +L R L+ ++ L
Sbjct: 353 VE---EGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL 409
Query: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ 330
E + L + QWE+ EG+ L++ L+ ++ ERD L A Q
Sbjct: 410 AGCQEAVNLLQQQHD-----QWEE---EGKALRQRLQKLTGERDTL-----------AGQ 450
Query: 331 MQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAE 390
L +V ++S+ +E +Q EL + L E RL N L
Sbjct: 451 TVDLQGEVD-----------SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL--- 496
Query: 391 QLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLR 450
QL + QG ++EQ EE L +V E ++L QE L+A++ +E L E++TLR
Sbjct: 497 QLQGDSAQGQKEEQQEE--LHLAVRERERL-----QEMLMGLEAKQ--SESLS-ELITLR 546
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
EALE + LEG+L +++E+TEV A R E + S+ L +++ RA
Sbjct: 547 EALES-----SHLEGEL-LRQEQTEVTAA---LARAEQSIAELSSSENTLKTEVADLRAA 597
Query: 511 VLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA-----ETLEQVRSIM 555
++L A +E + D V L+Q L ++LE Q+ E EQ R+ +
Sbjct: 598 AVKLSA---LNEALALDKVGLNQQL-LQLEEENQSVCSRMEAAEQARNAL 643
Score = 68.2 bits (165), Expect = 2e-11
Identities = 131/586 (22%), Positives = 238/586 (40%), Gaps = 66/586 (11%)
Query: 3 AAAPVAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAE 62
+A + ++ E R AL++ + A G+A L+ L LA E+ET++ +
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ 1445
Query: 63 VSESTKAEAVAAVQ------RQCQEEVASLQAILKD--SISSYEAQITALKQERQQQQQD 114
E + AA++ ++ +EV Q +++ S + QER+Q+
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV 1505
Query: 115 CEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAE 174
E+ REL + ++ LE +EK + E R V ++K++ L+ L E
Sbjct: 1506 QREQIRELEKDRETQRNVLEHQLLE--LEKKDQMIESQRGQVQDLKKQLVTLECLALELE 1563
Query: 175 ELIQEIQRRPRHAPSLHGSTE-----LLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCD 229
E +++ + + L G E L L+ D LEE S + A + H+ +
Sbjct: 1564 ENHHKMECQQKLIKELEGQRETQRVALTHLTLD-------LEERSQEL-QAQSSQIHDLE 1615
Query: 230 DSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPD 289
+++ + L + R+ + Q + L + + L Q++ D
Sbjct: 1616 SHSTVLARELQE---RDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672
Query: 290 TQWEQ--------------LQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLL 335
+ Q L+ GR+L + + +ER E +G ++ + M+++L
Sbjct: 1673 QRTRQTKILEEDLEQIKLSLRERGRELTTQRQ-LMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 336 AQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA--EQLP 393
++ E+ + Q + + QE +L H+ + L++ Q + +QL
Sbjct: 1732 ---RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 394 SSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGA---ERLRIEIVTLR 450
+ QG +EQ SL S + E Q+ L QE A Q Q+ ER++ + L+
Sbjct: 1789 EAREQGELKEQ----SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
ALE+ + G+L+ +E+ LE L E RVQ + L DL +E R +
Sbjct: 1845 GALEQAHMTLKERHGELQDHKEQARRLEEELA---VEGRRVQALEE--VLGDLRAESREQ 1899
Query: 511 VLRLQA-ELETSEQVQRDFVRLS-------QALQVRLERIRQAETL 548
L A + + +EQ Q V QA V ER ++ E L
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Score = 65.9 bits (159), Expect = 1e-10
Identities = 125/530 (23%), Positives = 206/530 (38%), Gaps = 93/530 (17%)
Query: 21 ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80
AL+DS Q A + EL LRAE + + E +A AE + +A AA+Q + Q
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982
Query: 81 E--EVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSL 138
E A L L+ S ++ +A + A + +Q ++ +E E+ Q Y D
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI----QDQDLRYQEDVQ 2038
Query: 139 EKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLR---AEELIQEIQ-----RRPRHAPSL 190
+ Q A D E L ++E E+L K L E +IQE Q R L
Sbjct: 2039 QLQQALAQRDEE------LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092
Query: 191 HGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLP 250
H S L L+ L + + E N + +LP
Sbjct: 2093 HQSVRELQLT---------LAQKEQEILELRETQQRN-----------------NLEALP 2126
Query: 251 QSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVS 310
S + SP +E++ L D+ +LQ E +LQ L
Sbjct: 2127 HSHK-TSPMEEQSLKL----------------------DSLEPRLQRELERLQAAL---- 2159
Query: 311 RERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTH 370
R+ + + R +D A + A V + +++ LQ +V + Q EL T
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 371 KCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARA 430
+ L E + L + S+A GS+ EQG + S V +Q R
Sbjct: 2220 RAL---------EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQ 2270
Query: 431 RLQAQEHGAERLRIE-------IVTLREALEEETVARASLEGQ-LRVQREETEVLEASLC 482
RL+ + RL I+ V LR LE+ R L+ + +R + + + +
Sbjct: 2271 RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATA 2330
Query: 483 SLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLS 532
S T+ + Q+ S A+ ++E + +V+ LQA+L + ++D++ S
Sbjct: 2331 SSPTQQDGRGQKNSDAK---CVAELQKEVVLLQAQLTLERKQKQDYITRS 2377
Score = 63.9 bits (154), Expect = 4e-10
Identities = 105/505 (20%), Positives = 212/505 (41%), Gaps = 59/505 (11%)
Query: 69 AEAVAAVQRQCQEEVASLQA---ILKDSISSYEAQITALKQERQQQQQDCEEKERELGRL 125
AEAVA+ + +++ Q +L+D + E ++T + E+ Q + ++ +R+L +
Sbjct: 1238 AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
Query: 126 KQLLSR-AYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRP 184
++ S+ +SLE ++ + HE + L+++L RAE E Q
Sbjct: 1298 QEEKSKWEGKQNSLESELMELHE--------------TMASLQSRLRRAELQRMEAQ--- 1340
Query: 185 RHAPSLHGSTELLPLSRDP-SPPLEPLEELSGDGGPAAEAFAHNCDD-SASISSFSLGGG 242
G ELL +++ + +E L+ + A A +D + S+ L
Sbjct: 1341 -------GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKL--- 1390
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
+ + R+ QE+ V+ G + E + L + + E L+ + ++L
Sbjct: 1391 --KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTL-AEREEEVETLRGQIQEL 1447
Query: 303 QKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQ 362
+K E + L L++ N++ Q Q + +++ +L L V + ++++ +Q
Sbjct: 1448 EKQREMQKAALELLSLDLKKRNQEVDLQ-QEQIQELEKCRSVLEHLPMAVQEREQKLTVQ 1506
Query: 363 MAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLC 422
++ K E +R E+Q L E+ Q + ++G+ + L + L + L
Sbjct: 1507 REQIRELEK--DRETQRNVLEHQLLELEK----KDQMIESQRGQVQDLKKQLVTL-ECLA 1559
Query: 423 CTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLC 482
+E +++ Q+ + L + T R AL T+ +L+ Q + LE+
Sbjct: 1560 LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST 1619
Query: 483 SLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERI 542
L E++ QE + QR ++ LQ + E + +D R Q L ++ ERI
Sbjct: 1620 VLARELQERDQE---------VKSQREQIEELQRQ---KEHLTQDLERRDQELMLQKERI 1667
Query: 543 RQAETLEQVRSIMDEAPLTDVRDIK 567
+ LE R+ + D+ IK
Sbjct: 1668 ---QVLEDQRTRQTKILEEDLEQIK 1689
Score = 60.1 bits (144), Expect = 5e-09
Identities = 143/654 (21%), Positives = 242/654 (37%), Gaps = 121/654 (18%)
Query: 2 AAAAPVAADDDERRRRPGAALEDSRS--QEGANGEAESGELSRL--RAELAGALAEMETM 57
AAA +A + E + ALE ++ ++ N E E R + ELA AL +E
Sbjct: 828 AAARQLAQAEQEGK----TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 58 KAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEE 117
K E+ + + A+Q Q +EE ++ L E + +L + Q Q++ +
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 118 KERELGRLK-----QLLSRAYPLDSLEKQMEKA------------------HEDSEKLRE 154
++L RL+ Q L L+ Q+++A E+S L +
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 155 IVLPMEKEIEELKAKLLRAEE----LIQEIQRRPRHAPS-------------------LH 191
+ ++K++E+LK++L+ ++ + QE+Q + R +
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 192 GSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQ 251
LL L S + L L D EA + SA + + L Q
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQD---MQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 252 SRQGLS-------PEQEETAS--------------LVSTGTLVPEGIYLPPPGYQLVPDT 290
Q L EQ+ AS L ST + + PG Q
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQA 1180
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLR---- 346
Q L + LQ+ L SV R EL G D A + L + L +
Sbjct: 1181 QLASLYS---ALQQALGSVCESRPELSGG-----GDSAPSVWGLEPDQNGARSLFKRGPL 1232
Query: 347 ---TLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAE------QLPSSAP 397
V+ A ++ + + T L +V++L E AE +L
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292
Query: 398 QGSQQE------QGEEESLPSSVPELQQLLCCTRQE-ARARLQAQEHGAERLRIEIVTLR 450
Q SQ + +G++ SL S + EL + + + RA LQ E ER ++
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
+ E + A +E R Q +LE L + R+ ++ +E +RA+
Sbjct: 1353 LTAQVEHLQAAVVEA--RAQASAAGILEEDLRTARSALKLKNEEVES-------ERERAQ 1403
Query: 511 VLRLQAELETSE--QVQRDFVRLSQALQVRLERIR----QAETLEQVRSIMDEA 558
L+ Q EL+ ++ +Q + L+Q L R E + Q + LE+ R + A
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Score = 58.2 bits (139), Expect = 2e-08
Identities = 117/585 (20%), Positives = 232/585 (39%), Gaps = 73/585 (12%)
Query: 22 LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81
LED R+++ E + L +++ L E+ T + + + +AE + +
Sbjct: 1670 LEDQRTRQTKILEED---LEQIKLSLRERGRELTTQRQLMQ----ERAEEGKGPSKAQRG 1722
Query: 82 EVASLQAILKDSISSYEAQ---ITALKQERQQQQQDCEEKERELGRLKQLLS-RAYPLDS 137
+ ++ IL+D E Q I L++ + Q +Q + R++G LLS R +
Sbjct: 1723 SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
Query: 138 LEKQMEKAHEDSE--------KLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPS 189
L++Q+++A E E +L E + + +EL+A ++ + +R A +
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADA 1842
Query: 190 LHGSTELLPLS--------RDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGG 241
L G+ E ++ +D LEE G +A LG
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE-----------VLGD 1891
Query: 242 GVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
S ++ L + E A T + +L D + E L+ E +
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 302 LQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQL---LRTLQGTVS----- 353
+ E+ + LQE L +++ + Q LL Q + S L TLQ ++
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 354 --QAQERVQLQMAELVTTHKCLHHEVKRLNE----ENQGLRAEQLPSSAPQGSQQEQGEE 407
Q +E +++Q E+ +V++L + ++ LR +Q ++EQ E
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQ---------EREQLLE 2062
Query: 408 ESLPSSVPE--LQQLLCCTRQEARARLQAQEHGAERLRI-------EIVTLREALEEETV 458
+SL V E +Q+ ++ ++ L++ EI+ LRE + +
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 459 ARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQ-AE 517
+ E++ L++ L+ E+ER+Q + + ++ ++A+ L L A+
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 518 LETSEQVQRDFVRLSQA--LQVRLERIRQAETLEQVRSIMDEAPL 560
+ S ++ QA L+ E+ R + LE R +++ L
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227
Score = 57.4 bits (137), Expect = 3e-08
Identities = 131/597 (21%), Positives = 238/597 (39%), Gaps = 98/597 (16%)
Query: 38 GELSRL-RAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISS 96
GEL R + E+ ALA E A SE+T VA ++ + A +A+ D +
Sbjct: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGL 615
Query: 97 YEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDS--------LEKQMEKAHED 148
+ Q+ L++E Q E E+ L+ L+ A LE Q++KA E
Sbjct: 616 NQ-QLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 149 SEKLREIVLPMEKEIEELKAKL-----------LRAEELIQEIQRRP------------- 184
+L+ + +++E EE++ KL + E+L QE +R+
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 185 -RHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGV 243
R +L L + RD E L+ LS E+ S+ + G
Sbjct: 735 VREKAAL--EVRLQAVERDRQDLAEQLQGLS-SAKELLESSLFEAQQQNSVIEVTKGQLE 791
Query: 244 GSSSSLPQSRQGL----------------SPEQEETASLVSTGTLVPEG---IYLPPPGY 284
++ Q+++ + EQE A+ EG + +
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851
Query: 285 QLVPD---TQWEQLQT-EGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQN 340
+ + +WE+ ++ ++L K LES+ RE+ EL+ L+ +Q ++ Q Q
Sbjct: 852 EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE------QQTEMEAIQAQR 905
Query: 341 SEQLLRT----LQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSA 396
E+ + Q + +ERV L + L+ T K L ++L Q ++ ++L
Sbjct: 906 EEERTQAESALCQMQLETEKERVSL-LETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
Query: 397 PQGSQQEQGEE--ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALE 454
G Q Q +E L + + + L ++E+ + LQ ++++ E L+
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD--------KMDLQKQVEDLK 1016
Query: 455 EETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ--EQSKAQLPDLLSEQRAKVL 512
+ VA+ + Q V++E E L + E R+Q+ E+ KA L L E+ ++L
Sbjct: 1017 SQLVAQD--DSQRLVEQEVQEKLRET-----QEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 513 RL-------QAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTD 562
L Q EL Q ++ + L ++E +RQ ++ + EA L +
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE 1126
Score = 52.8 bits (125), Expect = 9e-07
Identities = 114/554 (20%), Positives = 200/554 (36%), Gaps = 68/554 (12%)
Query: 22 LEDSRSQEGANGEAESGELSRLRAELAGALAEMETM-------KAVAEVSESTKAEAVAA 74
LE+ + EA + L+ +LA A E + +A + +E AE A
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681
Query: 75 VQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYP 134
+ R QEE +Q L +S EA T L+Q Q+ ++ E R + + L+
Sbjct: 682 L-RDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKA- 739
Query: 135 LDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEE-----------LIQEIQRR 183
+LE +++ D + L E + + E L++ L A++ L +IQ
Sbjct: 740 --ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTV 797
Query: 184 PRHAPSLHGSTELLPLSRDPS---------PPLEPLEELSGDGGPAAEA--FAHNCDDSA 232
+ + G L L D L + +G A E AH + +
Sbjct: 798 TQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857
Query: 233 SISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQW 292
+ L ++ + L E+ E + E I +
Sbjct: 858 LREKWEKERS-WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA---------QREE 907
Query: 293 EQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTV 352
E+ Q E Q LE+ +ER L E L ++ ++ A Q L Q+ + Q T
Sbjct: 908 ERTQAESALCQMQLET-EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966
Query: 353 SQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGL---------RAEQLPSSAPQGSQQE 403
Q ++Q EL + ++ L EE+ L + E L S +
Sbjct: 967 GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ 1026
Query: 404 QGEEESLPSSVPELQQL-------------LCCTRQEARARLQAQEHGAERLRIEIVTLR 450
+ E+ + + E Q+ L + E RL + + E+ LR
Sbjct: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEM--ERVQQEQSKAQLPDLLSEQR 508
+ ++E + L Q+ + R+E + EA + ++ E ++ QL L Q
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
Query: 509 AKVLRLQAELETSE 522
AK +LQ L ++E
Sbjct: 1147 AKAAQLQLRLRSTE 1160
Score = 30.0 bits (66), Expect = 5.9
Identities = 43/202 (21%), Positives = 82/202 (40%), Gaps = 13/202 (6%)
Query: 23 EDSRSQEGANGEAESGELSRLRAELAGALAEMETM-KAVAEVSESTKAEAVAAVQRQCQE 81
E R Q+ + E RL + A + AE+ + + ++ E + EA + ++
Sbjct: 2207 EQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ 2266
Query: 82 EVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQ 141
L+ +++ E + L++ Q + E+ ERE +LK+ RA SLE
Sbjct: 2267 SWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEIS 2326
Query: 142 MEKAHEDSEK--------LREIVLPMEKEIEELKAKLL----RAEELIQEIQRRPRHAPS 189
A +++ + V ++KE+ L+A+L + ++ I + R
Sbjct: 2327 KATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAG 2386
Query: 190 LHGSTELLPLSRDPSPPLEPLE 211
LH S L+ +P LE
Sbjct: 2387 LHHSLSHSLLAVAQAPEATVLE 2408
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 73.6 bits (179), Expect = 5e-13
Identities = 127/516 (24%), Positives = 215/516 (41%), Gaps = 83/516 (16%)
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDS---ISSYEAQITALKQER-----------Q 109
+E K A VQ QC A LQA L S ++ EAQ+ L+ ER Q
Sbjct: 558 TEYQKQLLAAQVQLQCSP--AELQAELLHSQARLAELEAQVRKLELERAQHELLLGSLQQ 615
Query: 110 QQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAK 169
Q Q D E E ++L +Y +++ E+ ++E+L L +E E+ +A+
Sbjct: 616 QHQADLELIESAHRSRIKVLETSY-----QQREERLRRENEELSARYLSQCQEAEQARAE 670
Query: 170 LL-----RAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAF 224
L R + QE + L ++ +L + RD L+ L+ L AA
Sbjct: 671 LTAQHQRRLAAIAQEKDQEMERLRELQRAS-ILDMRRDHEEQLQRLKLLKDREVDAAT-- 727
Query: 225 AHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGY 284
SA+ + SL + S LS E AS ++T GI
Sbjct: 728 ------SATSHTRSLNSIIHQMEKFSSSLHELSSRVE--ASHLTTSQERELGIRQR---- 775
Query: 285 QLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVL-------LAQ 337
D Q LQ Q Q+D+E ER QE + + +Q ++L A+
Sbjct: 776 ----DEQLRALQERLGQQQRDMEE---ERSRQQEVIGKMEARLNEQSRLLEQERWRVTAE 828
Query: 338 VQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVK----RLNEENQGLRAEQLP 393
+E + R L+ +++ ++ AEL L E K + EE + L AE
Sbjct: 829 QSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAE 888
Query: 394 SSAPQGSQQEQGEEESLPSSVPELQQ---LLCCTRQEARARLQAQEHGAERLRIEIVTLR 450
SA Q +E+ E E+ + + Q+ L+ +++A +++A E AE ++
Sbjct: 889 FSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQL------ 942
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
RA+LE + + R E E + A+ +LR ++ R ++ +S +++ E+ +
Sbjct: 943 ------AAERAALEQERQELRLEKERINAT--ALRVKL-RAEEVESMSKVASEKYEEGER 993
Query: 511 VLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAE 546
LR ++QVQ + QA+Q + ER+R+ E
Sbjct: 994 ALR------EAQQVQAEQQARLQAVQQQQERLRKQE 1023
Score = 30.8 bits (68), Expect = 3.5
Identities = 34/147 (23%), Positives = 65/147 (44%), Gaps = 14/147 (9%)
Query: 25 SRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVA 84
S ++E A + + EL +LA A +E + + E + A A + EEV
Sbjct: 920 SLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRL-EKERINATALRVKLRAEEVE 978
Query: 85 SLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEK 144
S+ + + YE AL++ +Q Q E++ L ++Q R L KQ +
Sbjct: 979 SMSKVASE---KYEEGERALREAQQVQ----AEQQARLQAVQQQQER------LRKQEQH 1025
Query: 145 AHEDSEKLREIVLPMEKEIEELKAKLL 171
H++ L + L +++ ++L + L+
Sbjct: 1026 MHQEHLSLAQQRLQLDRARQDLPSSLV 1052
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 71.2 bits (173), Expect = 2e-12
Identities = 128/579 (22%), Positives = 240/579 (41%), Gaps = 130/579 (22%)
Query: 6 PVAADDDERRRRPGA---ALEDSRSQEGANGEAESGELSRLRAELA---GALAEMETM-K 58
P+ +D + + G ALE R++ +S +L +L EL A A +E + K
Sbjct: 391 PIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVK 450
Query: 59 AVAEVSE--STKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCE 116
+A + E S K + + R+ QE +A SS+E ++ L++E++QQQ++ E
Sbjct: 451 EMAPLQEELSGKGQEADQLWRRLQELLAHT--------SSWEEELAELRREKKQQQEEKE 502
Query: 117 EKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEEL 176
E+E+ L + L LE Q+ + + ++EE K +L++ ++
Sbjct: 503 LLEQEVRSLTR------QLQFLETQLAQVSQH-----------VSDLEEQKKQLIQDKDH 545
Query: 177 IQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISS 236
+ S + LE L+G GP + ++S
Sbjct: 546 L--------------------------SQQVGMLERLAGPPGPELPVAGEKNEALVPVNS 579
Query: 237 FSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQ 296
SL G + ++GL Q + T V EG +Q E+L+
Sbjct: 580 -SLQEAWGKPE---EEQRGLQEAQLD-------DTKVQEG-------------SQEEELR 615
Query: 297 TEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQ 356
R+L+K+L++V R++L EG ++Q L A Q +Q +QG+++
Sbjct: 616 QANRELEKELQNVV-GRNQLLEG----------KLQALQADYQALQQRESAIQGSLAS-- 662
Query: 357 ERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPE 416
++ + A + + + + + + ++A+ A Q ++GE + L V +
Sbjct: 663 --LEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAI--LQSKEGECQQLREEVEQ 718
Query: 417 LQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALE----------EETVARASL-EG 465
QQL +E RA L++Q +L IE++T + + E A+ +L +
Sbjct: 719 CQQLAEARHRELRA-LESQCQQQTQL-IEVLTAEKGQQGVGPPTDNEARELAAQLALSQA 776
Query: 466 QLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQ 525
QL V + E + L+A + L+ +M +Q K +Q++L +E V
Sbjct: 777 QLEVHQGEVQRLQAQVVDLQAKMRAALDDQDK----------------VQSQLSMAEAVL 820
Query: 526 RDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVR 564
R+ L Q L+ + E + +A E ++ E L + R
Sbjct: 821 REHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEER 859
Score = 62.8 bits (151), Expect = 8e-10
Identities = 124/603 (20%), Positives = 228/603 (37%), Gaps = 102/603 (16%)
Query: 11 DDERRRRPGAALEDSRSQEG--------ANGEAES-------------GELSRLRAE--- 46
++E+R A L+D++ QEG AN E E G+L L+A+
Sbjct: 589 EEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQA 648
Query: 47 -------LAGALAEMETMKA-VAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYE 98
+ G+LA +E +A + + + +A +A R+ +E + + A + + S E
Sbjct: 649 LQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAV--RKAKEAMKAQMAEKEAILQSKE 706
Query: 99 AQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLP 158
+ L++E +Q QQ E + REL L+ + + Q+ + + + + P
Sbjct: 707 GECQQLREEVEQCQQLAEARHRELRALESQCQQ-------QTQLIEVLTAEKGQQGVGPP 759
Query: 159 MEKEIEELKAKLLRAEELIQ----EIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEELS 214
+ E EL A+L ++ ++ E+QR +++ L L+ +++
Sbjct: 760 TDNEARELAAQLALSQAQLEVHQGEVQRL---------QAQVVDLQAKMRAALDDQDKVQ 810
Query: 215 GDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVP 274
A + + + L Q + QEE A
Sbjct: 811 SQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQR---- 866
Query: 275 EGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVL 334
+ + LQ E Q + E E ELQE L R+N D A+ +
Sbjct: 867 --------------EEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQV 912
Query: 335 LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPS 394
A E++ L V + Q+ + E + L +V L +E + L+ + +
Sbjct: 913 CALTVEKERVEEALACAVQELQDAKEAASRE----REGLERQVAGLQQEKESLQEKLKAA 968
Query: 395 SAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRI----EIVTLR 450
A G S+P LQ L Q A++ +A L+ EI+ +
Sbjct: 969 KAAAG-------------SLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQ 1015
Query: 451 EALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAK 510
L+ SL GQL Q + + E ++ L+ + ++ S + L+E +A
Sbjct: 1016 SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS--NHLAECQAA 1073
Query: 511 VLRLQAE----LETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDI 566
+LR E E E+ Q++ + + +Q ++ Q T R D+ L D+ D+
Sbjct: 1074 MLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVT---NRERNDQKMLADLDDL 1130
Query: 567 KDT 569
T
Sbjct: 1131 NRT 1133
Score = 47.4 bits (111), Expect = 4e-05
Identities = 69/316 (21%), Positives = 130/316 (41%), Gaps = 64/316 (20%)
Query: 293 EQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQ-------------MQVLLAQVQ 339
+QL+ +QL++ ++ + RE EL+ + + E + + L+A++Q
Sbjct: 240 DQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQ 299
Query: 340 NSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQG 399
++ + Q TV + Q +Q + H ++RL Q L A++L ++
Sbjct: 300 KQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPL-AQELEATRDSL 358
Query: 400 SQQEQ-----------------------GEEESLPSSVPELQQLLCCTRQEARARLQAQE 436
++ Q G +E +PS + QE +LQA E
Sbjct: 359 DKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQ-------EMQELGEKLQALE 411
Query: 437 HGAERLRIEIVTLREALEEETVARASLEGQLRVQ-REETEVLEASLCSLRTEMERVQQE- 494
ER ++E V +++ + E + + E QL+ R E L + L+ E+ QE
Sbjct: 412 R--ERTKVEEVNRQQSAQLEQLVK---ELQLKEDARASLERLVKEMAPLQEELSGKGQEA 466
Query: 495 -QSKAQLPDL----------LSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIR 543
Q +L +L L+E R + + Q E E EQ R R Q L+ +L ++
Sbjct: 467 DQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVS 526
Query: 544 Q--AETLEQVRSIMDE 557
Q ++ EQ + ++ +
Sbjct: 527 QHVSDLEEQKKQLIQD 542
Score = 38.1 bits (87), Expect = 0.022
Identities = 52/196 (26%), Positives = 85/196 (43%), Gaps = 31/196 (15%)
Query: 9 ADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGA---LAEMETMKAVAEVSE 65
AD+ ++R AL++ SQ + E E + L+ +L A AE+ V +
Sbjct: 860 ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEK 919
Query: 66 STKAEAVAAVQRQCQE--EVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
EA+A ++ Q+ E AS + E Q+ L+QE KE
Sbjct: 920 ERVEEALACAVQELQDAKEAASRER------EGLERQVAGLQQE----------KESLQE 963
Query: 124 RLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRR 183
+LK + A L L+ Q+ +A + ++ L+E +E+ LK + L AE I + Q R
Sbjct: 964 KLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAA---HQELNTLKFQ-LSAE--IMDYQSR 1017
Query: 184 PRHA----PSLHGSTE 195
++A SL G E
Sbjct: 1018 LKNAGEECKSLRGQLE 1033
Score = 35.8 bits (81), Expect = 0.11
Identities = 48/217 (22%), Positives = 91/217 (41%), Gaps = 43/217 (19%)
Query: 357 ERVQLQMAELVTTHKCLHHEVKRLNEENQGLRA------EQLPSSAPQGSQQEQGEEESL 410
+ ++L++ +L K L +++L+ ENQ LRA EQL + +G + + L
Sbjct: 233 DEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAE-DNVRL 291
Query: 411 PSSVPELQ------QLLCCTRQEARARLQAQEHGA------------------ERLRIEI 446
V ELQ Q T +E + LQ E GA + L E+
Sbjct: 292 TCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQEL 351
Query: 447 VTLREALEEETVARASLEGQLRVQREETEVL-------EASLCSLRTEMERVQQ-----E 494
R++L+++ AS G L + +++ + E EM+ + + E
Sbjct: 352 EATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALE 411
Query: 495 QSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRL 531
+ + ++ ++ +Q A++ +L EL+ E + RL
Sbjct: 412 RERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL 448
Score = 35.4 bits (80), Expect = 0.14
Identities = 47/203 (23%), Positives = 83/203 (40%), Gaps = 26/203 (12%)
Query: 1 MAAAAPVAADDDERRRRPGAALEDSRSQEGANGEAES-GELSRLRAELAGALAEMETMKA 59
+A A D E R LE R G E ES E + AG+L ++ A
Sbjct: 926 LACAVQELQDAKEAASREREGLE--RQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLA 983
Query: 60 VAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKE 119
AE + ++Q +E+ +L+ L I Y++++ +E + + EE+
Sbjct: 984 QAE-------QRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQG 1036
Query: 120 RELGRLKQLLS--RAYPLDSLEK-------------QMEKAHEDSEKLREIVLPMEKEIE 164
R+L ++ + +A D EK M + ++ LRE + +KE+E
Sbjct: 1037 RQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE 1096
Query: 165 ELKAKLLR-AEELIQEIQRRPRH 186
+ K+ +L QE+ R R+
Sbjct: 1097 KATTKIQEYYNKLCQEVTNRERN 1119
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 71.2 bits (173), Expect = 2e-12
Identities = 117/537 (21%), Positives = 207/537 (38%), Gaps = 93/537 (17%)
Query: 23 EDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEE 82
ED S+ A +AE + L EL E+E + +ST + +R+ +E
Sbjct: 1125 EDLDSERAARNKAEKQKRD-LGEELEALKTELE------DTLDSTATQQELRAKRE--QE 1175
Query: 83 VASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQM 142
V L+ L + S+EAQ+ ++Q+ Q ++ E+ + R K LD ++ +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA------NLDKNKQTL 1229
Query: 143 EKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRD 202
EK + D ++ ++E+E K KL E +QE+Q +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSK------------------- 1267
Query: 203 PSPPLEPLEELSGDGGPAAEAF---AHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE 259
DG A H + + L G + L + LS +
Sbjct: 1268 -----------CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 260 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEG 319
++T L+ T +L T+ QL+ E LQ L+ + L+
Sbjct: 1317 LQDTQELLQEETR-----------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 320 LRRSN---EDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
+ N D K++Q + V+ E+ + Q + E + Q E + L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----ENLTQQYEEKAAAYDKLEKT 1421
Query: 377 VKRLNEENQGLRAE-----QLPSSAPQGSQ---QEQGEEESLPSSVPELQQLLCCTRQEA 428
RL +E L + QL S+ + + Q EE+++ S + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD---------ERD 1472
Query: 429 RARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEM 488
RA +A+E + L +L ALEE A+ LE ++ + E E L +S + +
Sbjct: 1473 RAEAEAREKETKAL-----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 489 ERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA 545
+ E+SK L + E + ++ L+ EL+ +E + QAL+ + ER QA
Sbjct: 1528 HEL--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Score = 62.0 bits (149), Expect = 1e-09
Identities = 120/620 (19%), Positives = 234/620 (37%), Gaps = 99/620 (15%)
Query: 35 AESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAI----- 89
A+ EL + E+ L E E + A+ + ++ Q +EE A+ Q +
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 90 --------LKDSISSYEAQITALKQERQQQQQ----------DCEEKERELGRLK----- 126
L+D I + Q L +ER+ ++ + EEK + L +LK
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 127 -------QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
+L LEK K D+ E + ++ +I ELK +L + EE +Q
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 180 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEE-LSGDGGPAAEAFAHNCDDSASISSFS 238
R + L R+ + L+E L + +A D + +
Sbjct: 1095 ALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 239 LGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE 298
+ L + + +QE A T++ + + ++ ++
Sbjct: 1153 --------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 299 GRQLQKDLESVSRER---DELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQA 355
+L + LE R + D+ ++ L + N D A +++VL Q E + L+ V +
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 356 Q------ERVQLQM------------------------------------AELVTTHKCL 373
Q ER + ++ ++L T + L
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 374 HHEVK-RLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTR---QEAR 429
E + +LN + + E+ +S +E +++L + L L ++ Q+
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 430 ARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME 489
+ ++A E G +R + EI L + EE+ A LE ++E + L L + R +
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 490 RVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA-ETL 548
++++Q K LL+E++ + E + +E R+ + +L LE +A E L
Sbjct: 1445 NLEKKQRK--FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 549 EQVRSIMDEAPLTDVRDIKD 568
E+ ++ +A + D+ KD
Sbjct: 1503 ERTNKML-KAEMEDLVSSKD 1521
Score = 55.1 bits (131), Expect = 2e-07
Identities = 107/541 (19%), Positives = 229/541 (42%), Gaps = 91/541 (16%)
Query: 27 SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASL 86
S G EAE G+ +L ++A ++++ + + + E+ + V+ RQ +EE SL
Sbjct: 1291 SVTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQ-EETRQKLNVSTKLRQLEEERNSL 1348
Query: 87 QAILKDS----------ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLD 136
Q L + IS+ Q++ K++ Q E E R ++ ++
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK------EIE 1402
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTEL 196
+L +Q E+ +KL + +++E+++L L +L+ ++++ R L
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL------ 1456
Query: 197 LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGL 256
L+ + + + D AEA A + A + +L + + L ++ + L
Sbjct: 1457 --LAEEKN-----ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 257 SPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDEL 316
E E+ LVS+ V + ++ +L+ R L+ +E + + +EL
Sbjct: 1510 KAEMED---LVSSKDDVGKNVH---------------ELEKSKRALETQMEEMKTQLEEL 1551
Query: 317 QEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
++ L+ + ED +++V + ++ Q R LQ Q +E+ + +L HE
Sbjct: 1552 EDELQ-ATEDAKLRLEVNMQALKG--QFERDLQARDEQNEEKRRQLQRQL--------HE 1600
Query: 377 VKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQE 436
+ E+ + RA A ++ +G+ + L ELQ A + ++ +E
Sbjct: 1601 YETELEDERKQRA-----LAAAAKKKLEGDLKDL-----ELQ---------ADSAIKGRE 1641
Query: 437 HGAERLR---IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ 493
++LR ++ + LE+ +R + + ++ + LEA L L+ ++ ++
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 494 EQSKAQL-PDLLSEQRAKVL----RLQAELETSE----QVQRDFVRLSQALQVRLERIRQ 544
+ +A L + L+E+ A L LQ E E Q++ + ++ +R+R+
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 545 A 545
A
Sbjct: 1762 A 1762
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 12 DERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKA 69
DE+RR A LE+ +E N EA S + + + E+ T ++ A+ +ES +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 70 EAVAA---VQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK 126
+ ++ + E ++++ K +I++ EA+I L++ Q +Q+ EK+ LK
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLK 1845
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
Q + L + Q+E + +E+ +E +++LK +L AEE Q I R
Sbjct: 1846 Q---KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Score = 48.5 bits (114), Expect = 2e-05
Identities = 56/249 (22%), Positives = 109/249 (43%), Gaps = 40/249 (16%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q E++Q + +LQK E + +EL+E L + + ++ +L Q+Q +L
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELY----- 903
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEEN---QGLRAEQLPSSAPQGSQQEQGEE 407
++A+E A+ + LH RL EE Q L+AE+ + +EQ EE
Sbjct: 904 --AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 408 ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQL 467
E + AR +LQ ++ AE + LE+E + ++ Q
Sbjct: 962 E-----------------EAARQKLQLEKVTAE-------AKIKKLEDEILV---MDDQN 994
Query: 468 RVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD 527
+E ++LE + L T + ++E+ L L ++ + + L+ L+ E+ +++
Sbjct: 995 NKLSKERKLLEERISDLTTNL--AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 528 FVRLSQALQ 536
+L + L+
Sbjct: 1053 LEKLKRKLE 1061
Score = 47.0 bits (110), Expect = 5e-05
Identities = 97/500 (19%), Positives = 189/500 (37%), Gaps = 99/500 (19%)
Query: 12 DERRRRPGAALEDSRSQ-EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
++ +R +E+ ++Q E E ++ E ++LR E+ M+ +K E + E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV-----NMQALKGQFERDLQARDE 1585
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ-----ERQQQQQDCEEKERELGRL 125
+RQ Q ++ + L+D A K+ + + Q D K RE +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-I 1644
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
KQL + ++++E A +++ EK+ + L+A L++ +E + +R +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 186 HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
A LE EEL
Sbjct: 1705 QA------------------DLEK-EEL-------------------------------- 1713
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L S G + Q+E L + + E + + + D + Q + QL +
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNE 1772
Query: 306 L---ESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS-EQLLRTLQGTVSQAQERVQL 361
L S +++ + ++ L R N++ ++ + V++ + + L+ ++Q +E+V+
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 362 QMAELVTTHKCLHHEVKRLNE-----ENQGLRAEQLPSSAPQGS--------QQEQGEEE 408
+ E K L + K+L E E++ AEQ A +G+ Q E+ EEE
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREAL---EEETVARASLEG 465
S Q + R++ + L E + E+ L+ L E + + G
Sbjct: 1893 S---------QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1943
Query: 466 QLRV------QREETEVLEA 479
RV EET+ +A
Sbjct: 1944 GRRVIENADGSEEETDTRDA 1963
Score = 43.1 bits (100), Expect = 7e-04
Identities = 108/550 (19%), Positives = 202/550 (36%), Gaps = 93/550 (16%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R + AL +R+ E A E E + L+AE+ ++ + + K V E+ +S +A
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 70 --EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQ 127
+ ++ Q +E LQA +D+ E + ALK + ++ Q +E+ E R Q
Sbjct: 1537 LETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 128 LLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE-ELKAKLLRAEELIQEIQRRPRH 186
Y E ED K R + +K++E +LK L+A+ I+
Sbjct: 1596 RQLHEY---------ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-------- 1638
Query: 187 APSLHGSTELLPLSRDPSPPLEPLE-ELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
G E + R ++ + EL E FA ++ S
Sbjct: 1639 -----GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE------- 1686
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L Q ++ L+ + +Q E +L ++
Sbjct: 1687 -ADLMQLQEDLAAAERAR-----------------------------KQADLEKEELAEE 1716
Query: 306 LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ--LQM 363
L S R+ LQ+ RR L A++ E+ L QG + +RV+ Q
Sbjct: 1717 LASSLSGRNALQDEKRR-----------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 364 AELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCC 423
AE ++ + NE + Q + + E + S++ L+ +
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 424 TRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
++ + ++ + L+ + L+E L + R E +E+ E A +
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----QYKEQAEKGNARVKQ 1881
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIR 543
L+ ++E ++E + A +LQ EL+ + + R AL+ +L R
Sbjct: 1882 LKRQLEEAEEESQRI---------NANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Query: 544 QAETLEQVRS 553
+ + RS
Sbjct: 1933 ETSFVPSRRS 1942
Score = 37.0 bits (84), Expect = 0.049
Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 10/153 (6%)
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+++ LL TRQE +QA+E ++ + L+E + L + + +E+ +
Sbjct: 840 KVKPLLQVTRQEEE--MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 476 VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQA- 534
E L + EM RV+ K +L ++L E A RL+ E + +Q+Q + +++Q
Sbjct: 898 A-ETELYAEAEEM-RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQM 952
Query: 535 --LQVRLERIRQAETLEQVRSIMDEAPLTDVRD 565
L+ +LE A Q+ + EA + + D
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 71.2 bits (173), Expect = 2e-12
Identities = 117/537 (21%), Positives = 207/537 (38%), Gaps = 93/537 (17%)
Query: 23 EDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEE 82
ED S+ A +AE + L EL E+E + +ST + +R+ +E
Sbjct: 1132 EDLDSERAARNKAEKQKRD-LGEELEALKTELE------DTLDSTATQQELRAKRE--QE 1182
Query: 83 VASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQM 142
V L+ L + S+EAQ+ ++Q+ Q ++ E+ + R K LD ++ +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA------NLDKNKQTL 1236
Query: 143 EKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRD 202
EK + D ++ ++E+E K KL E +QE+Q +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSK------------------- 1274
Query: 203 PSPPLEPLEELSGDGGPAAEAF---AHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE 259
DG A H + + L G + L + LS +
Sbjct: 1275 -----------CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 260 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEG 319
++T L+ T +L T+ QL+ E LQ L+ + L+
Sbjct: 1324 LQDTQELLQEETR-----------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 320 LRRSN---EDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
+ N D K++Q + V+ E+ + Q + E + Q E + L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----ENLTQQYEEKAAAYDKLEKT 1428
Query: 377 VKRLNEENQGLRAE-----QLPSSAPQGSQ---QEQGEEESLPSSVPELQQLLCCTRQEA 428
RL +E L + QL S+ + + Q EE+++ S + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD---------ERD 1479
Query: 429 RARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEM 488
RA +A+E + L +L ALEE A+ LE ++ + E E L +S + +
Sbjct: 1480 RAEAEAREKETKAL-----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 489 ERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA 545
+ E+SK L + E + ++ L+ EL+ +E + QAL+ + ER QA
Sbjct: 1535 HEL--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Score = 62.0 bits (149), Expect = 1e-09
Identities = 120/620 (19%), Positives = 234/620 (37%), Gaps = 99/620 (15%)
Query: 35 AESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAI----- 89
A+ EL + E+ L E E + A+ + ++ Q +EE A+ Q +
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 90 --------LKDSISSYEAQITALKQERQQQQQ----------DCEEKERELGRLK----- 126
L+D I + Q L +ER+ ++ + EEK + L +LK
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 127 -------QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
+L LEK K D+ E + ++ +I ELK +L + EE +Q
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 180 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEE-LSGDGGPAAEAFAHNCDDSASISSFS 238
R + L R+ + L+E L + +A D + +
Sbjct: 1102 ALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 239 LGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE 298
+ L + + +QE A T++ + + ++ ++
Sbjct: 1160 --------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 299 GRQLQKDLESVSRER---DELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQA 355
+L + LE R + D+ ++ L + N D A +++VL Q E + L+ V +
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 356 Q------ERVQLQM------------------------------------AELVTTHKCL 373
Q ER + ++ ++L T + L
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 374 HHEVK-RLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTR---QEAR 429
E + +LN + + E+ +S +E +++L + L L ++ Q+
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 430 ARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME 489
+ ++A E G +R + EI L + EE+ A LE ++E + L L + R +
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 490 RVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA-ETL 548
++++Q K LL+E++ + E + +E R+ + +L LE +A E L
Sbjct: 1452 NLEKKQRK--FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 549 EQVRSIMDEAPLTDVRDIKD 568
E+ ++ +A + D+ KD
Sbjct: 1510 ERTNKML-KAEMEDLVSSKD 1528
Score = 55.1 bits (131), Expect = 2e-07
Identities = 107/541 (19%), Positives = 229/541 (42%), Gaps = 91/541 (16%)
Query: 27 SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASL 86
S G EAE G+ +L ++A ++++ + + + E+ + V+ RQ +EE SL
Sbjct: 1298 SVTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQ-EETRQKLNVSTKLRQLEEERNSL 1355
Query: 87 QAILKDS----------ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLD 136
Q L + IS+ Q++ K++ Q E E R ++ ++
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK------EIE 1409
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTEL 196
+L +Q E+ +KL + +++E+++L L +L+ ++++ R L
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL------ 1463
Query: 197 LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGL 256
L+ + + + D AEA A + A + +L + + L ++ + L
Sbjct: 1464 --LAEEKN-----ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 257 SPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDEL 316
E E+ LVS+ V + ++ +L+ R L+ +E + + +EL
Sbjct: 1517 KAEMED---LVSSKDDVGKNVH---------------ELEKSKRALETQMEEMKTQLEEL 1558
Query: 317 QEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
++ L+ + ED +++V + ++ Q R LQ Q +E+ + +L HE
Sbjct: 1559 EDELQ-ATEDAKLRLEVNMQALKG--QFERDLQARDEQNEEKRRQLQRQL--------HE 1607
Query: 377 VKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQE 436
+ E+ + RA A ++ +G+ + L ELQ A + ++ +E
Sbjct: 1608 YETELEDERKQRA-----LAAAAKKKLEGDLKDL-----ELQ---------ADSAIKGRE 1648
Query: 437 HGAERLR---IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ 493
++LR ++ + LE+ +R + + ++ + LEA L L+ ++ ++
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 494 EQSKAQL-PDLLSEQRAKVL----RLQAELETSE----QVQRDFVRLSQALQVRLERIRQ 544
+ +A L + L+E+ A L LQ E E Q++ + ++ +R+R+
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 545 A 545
A
Sbjct: 1769 A 1769
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 12 DERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKA 69
DE+RR A LE+ +E N EA S + + + E+ T ++ A+ +ES +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 70 EAVAA---VQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK 126
+ ++ + E ++++ K +I++ EA+I L++ Q +Q+ EK+ LK
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLK 1852
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
Q + L + Q+E + +E+ +E +++LK +L AEE Q I R
Sbjct: 1853 Q---KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Score = 48.5 bits (114), Expect = 2e-05
Identities = 56/249 (22%), Positives = 109/249 (43%), Gaps = 40/249 (16%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q E++Q + +LQK E + +EL+E L + + ++ +L Q+Q +L
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELY----- 910
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEEN---QGLRAEQLPSSAPQGSQQEQGEE 407
++A+E A+ + LH RL EE Q L+AE+ + +EQ EE
Sbjct: 911 --AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 408 ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQL 467
E + AR +LQ ++ AE + LE+E + ++ Q
Sbjct: 969 E-----------------EAARQKLQLEKVTAE-------AKIKKLEDEILV---MDDQN 1001
Query: 468 RVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD 527
+E ++LE + L T + ++E+ L L ++ + + L+ L+ E+ +++
Sbjct: 1002 NKLSKERKLLEERISDLTTNL--AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 528 FVRLSQALQ 536
+L + L+
Sbjct: 1060 LEKLKRKLE 1068
Score = 47.0 bits (110), Expect = 5e-05
Identities = 97/500 (19%), Positives = 189/500 (37%), Gaps = 99/500 (19%)
Query: 12 DERRRRPGAALEDSRSQ-EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
++ +R +E+ ++Q E E ++ E ++LR E+ M+ +K E + E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV-----NMQALKGQFERDLQARDE 1592
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ-----ERQQQQQDCEEKERELGRL 125
+RQ Q ++ + L+D A K+ + + Q D K RE +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-I 1651
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
KQL + ++++E A +++ EK+ + L+A L++ +E + +R +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 186 HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
A LE EEL
Sbjct: 1712 QA------------------DLEK-EEL-------------------------------- 1720
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L S G + Q+E L + + E + + + D + Q + QL +
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNE 1779
Query: 306 L---ESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS-EQLLRTLQGTVSQAQERVQL 361
L S +++ + ++ L R N++ ++ + V++ + + L+ ++Q +E+V+
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 362 QMAELVTTHKCLHHEVKRLNE-----ENQGLRAEQLPSSAPQGS--------QQEQGEEE 408
+ E K L + K+L E E++ AEQ A +G+ Q E+ EEE
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREAL---EEETVARASLEG 465
S Q + R++ + L E + E+ L+ L E + + G
Sbjct: 1900 S---------QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSG 1950
Query: 466 QLRV------QREETEVLEA 479
RV EET+ +A
Sbjct: 1951 GRRVIENADGSEEETDTRDA 1970
Score = 43.1 bits (100), Expect = 7e-04
Identities = 108/550 (19%), Positives = 202/550 (36%), Gaps = 93/550 (16%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R + AL +R+ E A E E + L+AE+ ++ + + K V E+ +S +A
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 70 --EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQ 127
+ ++ Q +E LQA +D+ E + ALK + ++ Q +E+ E R Q
Sbjct: 1544 LETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 128 LLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE-ELKAKLLRAEELIQEIQRRPRH 186
Y E ED K R + +K++E +LK L+A+ I+
Sbjct: 1603 RQLHEY---------ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-------- 1645
Query: 187 APSLHGSTELLPLSRDPSPPLEPLE-ELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
G E + R ++ + EL E FA ++ S
Sbjct: 1646 -----GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE------- 1693
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L Q ++ L+ + +Q E +L ++
Sbjct: 1694 -ADLMQLQEDLAAAERAR-----------------------------KQADLEKEELAEE 1723
Query: 306 LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQ--LQM 363
L S R+ LQ+ RR L A++ E+ L QG + +RV+ Q
Sbjct: 1724 LASSLSGRNALQDEKRR-----------LEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 364 AELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCC 423
AE ++ + NE + Q + + E + S++ L+ +
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 424 TRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCS 483
++ + ++ + L+ + L+E L + R E +E+ E A +
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----QYKEQAEKGNARVKQ 1888
Query: 484 LRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIR 543
L+ ++E ++E + A +LQ EL+ + + R AL+ +L R
Sbjct: 1889 LKRQLEEAEEESQRI---------NANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Query: 544 QAETLEQVRS 553
+ + RS
Sbjct: 1940 ETSFVPSRRS 1949
Score = 37.0 bits (84), Expect = 0.049
Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 10/153 (6%)
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+++ LL TRQE +QA+E ++ + L+E + L + + +E+ +
Sbjct: 847 KVKPLLQVTRQEEE--MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 476 VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQA- 534
E L + EM RV+ K +L ++L E A RL+ E + +Q+Q + +++Q
Sbjct: 905 A-ETELYAEAEEM-RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQM 959
Query: 535 --LQVRLERIRQAETLEQVRSIMDEAPLTDVRD 565
L+ +LE A Q+ + EA + + D
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 71.2 bits (173), Expect = 2e-12
Identities = 117/537 (21%), Positives = 207/537 (38%), Gaps = 93/537 (17%)
Query: 23 EDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEE 82
ED S+ A +AE + L EL E+E + +ST + +R+ +E
Sbjct: 1132 EDLDSERAARNKAEKQKRD-LGEELEALKTELE------DTLDSTATQQELRAKRE--QE 1182
Query: 83 VASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQM 142
V L+ L + S+EAQ+ ++Q+ Q ++ E+ + R K LD ++ +
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA------NLDKNKQTL 1236
Query: 143 EKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRD 202
EK + D ++ ++E+E K KL E +QE+Q +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSK------------------- 1274
Query: 203 PSPPLEPLEELSGDGGPAAEAF---AHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE 259
DG A H + + L G + L + LS +
Sbjct: 1275 -----------CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 260 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEG 319
++T L+ T +L T+ QL+ E LQ L+ + L+
Sbjct: 1324 LQDTQELLQEETR-----------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 320 LRRSN---EDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
+ N D K++Q + V+ E+ + Q + E + Q E + L
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----ENLTQQYEEKAAAYDKLEKT 1428
Query: 377 VKRLNEENQGLRAE-----QLPSSAPQGSQ---QEQGEEESLPSSVPELQQLLCCTRQEA 428
RL +E L + QL S+ + + Q EE+++ S + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD---------ERD 1479
Query: 429 RARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEM 488
RA +A+E + L +L ALEE A+ LE ++ + E E L +S + +
Sbjct: 1480 RAEAEAREKETKAL-----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 489 ERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA 545
+ E+SK L + E + ++ L+ EL+ +E + QAL+ + ER QA
Sbjct: 1535 HEL--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Score = 62.0 bits (149), Expect = 1e-09
Identities = 120/620 (19%), Positives = 234/620 (37%), Gaps = 99/620 (15%)
Query: 35 AESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAI----- 89
A+ EL + E+ L E E + A+ + ++ Q +EE A+ Q +
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 90 --------LKDSISSYEAQITALKQERQQQQQ----------DCEEKERELGRLK----- 126
L+D I + Q L +ER+ ++ + EEK + L +LK
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 127 -------QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
+L LEK K D+ E + ++ +I ELK +L + EE +Q
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 180 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEE-LSGDGGPAAEAFAHNCDDSASISSFS 238
R + L R+ + L+E L + +A D + +
Sbjct: 1102 ALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 239 LGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE 298
+ L + + +QE A T++ + + ++ ++
Sbjct: 1160 --------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 299 GRQLQKDLESVSRER---DELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQA 355
+L + LE R + D+ ++ L + N D A +++VL Q E + L+ V +
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 356 Q------ERVQLQM------------------------------------AELVTTHKCL 373
Q ER + ++ ++L T + L
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 374 HHEVK-RLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTR---QEAR 429
E + +LN + + E+ +S +E +++L + L L ++ Q+
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 430 ARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME 489
+ ++A E G +R + EI L + EE+ A LE ++E + L L + R +
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 490 RVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA-ETL 548
++++Q K LL+E++ + E + +E R+ + +L LE +A E L
Sbjct: 1452 NLEKKQRK--FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 549 EQVRSIMDEAPLTDVRDIKD 568
E+ ++ +A + D+ KD
Sbjct: 1510 ERTNKML-KAEMEDLVSSKD 1528
Score = 55.1 bits (131), Expect = 2e-07
Identities = 107/541 (19%), Positives = 229/541 (42%), Gaps = 91/541 (16%)
Query: 27 SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASL 86
S G EAE G+ +L ++A ++++ + + + E+ + V+ RQ +EE SL
Sbjct: 1298 SVTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQ-EETRQKLNVSTKLRQLEEERNSL 1355
Query: 87 QAILKDS----------ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLD 136
Q L + IS+ Q++ K++ Q E E R ++ ++
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK------EIE 1409
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTEL 196
+L +Q E+ +KL + +++E+++L L +L+ ++++ R L
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL------ 1463
Query: 197 LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGL 256
L+ + + + D AEA A + A + +L + + L ++ + L
Sbjct: 1464 --LAEEKN-----ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 257 SPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDEL 316
E E+ LVS+ V + ++ +L+ R L+ +E + + +EL
Sbjct: 1517 KAEMED---LVSSKDDVGKNVH---------------ELEKSKRALETQMEEMKTQLEEL 1558
Query: 317 QEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
++ L+ + ED +++V + ++ Q R LQ Q +E+ + +L HE
Sbjct: 1559 EDELQ-ATEDAKLRLEVNMQALKG--QFERDLQARDEQNEEKRRQLQRQL--------HE 1607
Query: 377 VKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQE 436
+ E+ + RA A ++ +G+ + L ELQ A + ++ +E
Sbjct: 1608 YETELEDERKQRA-----LAAAAKKKLEGDLKDL-----ELQ---------ADSAIKGRE 1648
Query: 437 HGAERLR---IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ 493
++LR ++ + LE+ +R + + ++ + LEA L L+ ++ ++
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 494 EQSKAQL-PDLLSEQRAKVL----RLQAELETSE----QVQRDFVRLSQALQVRLERIRQ 544
+ +A L + L+E+ A L LQ E E Q++ + ++ +R+R+
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 545 A 545
A
Sbjct: 1769 A 1769
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 12 DERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKA 69
DE+RR A LE+ +E N EA S + + + E+ T ++ A+ +ES +
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 70 EAVAA---VQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK 126
+ ++ + E ++++ K +I++ EA+I L++ Q +Q+ EK+ LK
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLK 1852
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
Q + L + Q+E + +E+ +E +++LK +L AEE Q I R
Sbjct: 1853 Q---KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Score = 48.5 bits (114), Expect = 2e-05
Identities = 56/249 (22%), Positives = 109/249 (43%), Gaps = 40/249 (16%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q E++Q + +LQK E + +EL+E L + + ++ +L Q+Q +L
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELY----- 910
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEEN---QGLRAEQLPSSAPQGSQQEQGEE 407
++A+E A+ + LH RL EE Q L+AE+ + +EQ EE
Sbjct: 911 --AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 408 ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQL 467
E + AR +LQ ++ AE + LE+E + ++ Q
Sbjct: 969 E-----------------EAARQKLQLEKVTAE-------AKIKKLEDEILV---MDDQN 1001
Query: 468 RVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD 527
+E ++LE + L T + ++E+ L L ++ + + L+ L+ E+ +++
Sbjct: 1002 NKLSKERKLLEERISDLTTNL--AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 528 FVRLSQALQ 536
+L + L+
Sbjct: 1060 LEKLKRKLE 1068
Score = 46.6 bits (109), Expect = 6e-05
Identities = 89/465 (19%), Positives = 177/465 (38%), Gaps = 90/465 (19%)
Query: 12 DERRRRPGAALEDSRSQ-EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
++ +R +E+ ++Q E E ++ E ++LR E+ M+ +K E + E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV-----NMQALKGQFERDLQARDE 1592
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ-----ERQQQQQDCEEKERELGRL 125
+RQ Q ++ + L+D A K+ + + Q D K RE +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-I 1651
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
KQL + ++++E A +++ EK+ + L+A L++ +E + +R +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 186 HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
A LE EEL
Sbjct: 1712 QA------------------DLEK-EEL-------------------------------- 1720
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L S G + Q+E L + + E + + + D + Q + QL +
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNE 1779
Query: 306 L---ESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS-EQLLRTLQGTVSQAQERVQL 361
L S +++ + ++ L R N++ ++ + V++ + + L+ ++Q +E+V+
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 362 QMAELVTTHKCLHHEVKRLNE-----ENQGLRAEQLPSSAPQGS--------QQEQGEEE 408
+ E K L + K+L E E++ AEQ A +G+ Q E+ EEE
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREAL 453
S Q + R++ + L E + E+ L+ L
Sbjct: 1900 S---------QRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 40.8 bits (94), Expect = 0.003
Identities = 103/500 (20%), Positives = 192/500 (38%), Gaps = 94/500 (18%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R + AL +R+ E A E E + L+AE+ ++ + + K V E+ +S +A
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 70 --EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQ 127
+ ++ Q +E LQA +D+ E + ALK + ++ Q +E+ E R Q
Sbjct: 1544 LETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 128 LLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE-ELKAKLLRAEELIQEIQRRPRH 186
Y E ED K R + +K++E +LK L+A+ I+
Sbjct: 1603 RQLHEY---------ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-------- 1645
Query: 187 APSLHGSTELLPLSRDPSPPLEPLE-ELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
G E + R ++ + EL E FA ++ S
Sbjct: 1646 -----GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE------- 1693
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L Q ++ L+ + +Q E +L ++
Sbjct: 1694 -ADLMQLQEDLAAAERAR-----------------------------KQADLEKEELAEE 1723
Query: 306 LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAE 365
L S R+ LQ+ RR A+ + L + N E + ++ QA E++ ++A
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA-EQLSNELAT 1782
Query: 366 LVTTHKCLHHEVKRLNEENQGLRAE------------------------QLPSSAPQGSQ 401
+T + ++L +N+ LR++ QL Q ++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 402 QEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEE-ETVAR 460
++Q +SL +L+++L E + Q +E AE+ + L+ LEE E ++
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ-AEKGNARVKQLKRQLEEAEEESQ 1901
Query: 461 ASLEGQLRVQREETEVLEAS 480
+ ++QRE E E++
Sbjct: 1902 RINANRRKLQRELDEATESN 1921
Score = 37.0 bits (84), Expect = 0.049
Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 10/153 (6%)
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+++ LL TRQE +QA+E ++ + L+E + L + + +E+ +
Sbjct: 847 KVKPLLQVTRQEEE--MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 476 VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQA- 534
E L + EM RV+ K +L ++L E A RL+ E + +Q+Q + +++Q
Sbjct: 905 A-ETELYAEAEEM-RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQM 959
Query: 535 --LQVRLERIRQAETLEQVRSIMDEAPLTDVRD 565
L+ +LE A Q+ + EA + + D
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 71.2 bits (173), Expect = 2e-12
Identities = 117/537 (21%), Positives = 207/537 (38%), Gaps = 93/537 (17%)
Query: 23 EDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEE 82
ED S+ A +AE + L EL E+E + +ST + +R+ +E
Sbjct: 1125 EDLDSERAARNKAEKQKRD-LGEELEALKTELE------DTLDSTATQQELRAKRE--QE 1175
Query: 83 VASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQM 142
V L+ L + S+EAQ+ ++Q+ Q ++ E+ + R K LD ++ +
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA------NLDKNKQTL 1229
Query: 143 EKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRD 202
EK + D ++ ++E+E K KL E +QE+Q +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQSK------------------- 1267
Query: 203 PSPPLEPLEELSGDGGPAAEAF---AHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPE 259
DG A H + + L G + L + LS +
Sbjct: 1268 -----------CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 260 QEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQEG 319
++T L+ T +L T+ QL+ E LQ L+ + L+
Sbjct: 1317 LQDTQELLQEETR-----------QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 320 LRRSN---EDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
+ N D K++Q + V+ E+ + Q + E + Q E + L
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----ENLTQQYEEKAAAYDKLEKT 1421
Query: 377 VKRLNEENQGLRAE-----QLPSSAPQGSQ---QEQGEEESLPSSVPELQQLLCCTRQEA 428
RL +E L + QL S+ + + Q EE+++ S + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD---------ERD 1472
Query: 429 RARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEM 488
RA +A+E + L +L ALEE A+ LE ++ + E E L +S + +
Sbjct: 1473 RAEAEAREKETKAL-----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 489 ERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA 545
+ E+SK L + E + ++ L+ EL+ +E + QAL+ + ER QA
Sbjct: 1528 HEL--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Score = 62.0 bits (149), Expect = 1e-09
Identities = 120/620 (19%), Positives = 234/620 (37%), Gaps = 99/620 (15%)
Query: 35 AESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAI----- 89
A+ EL + E+ L E E + A+ + ++ Q +EE A+ Q +
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 90 --------LKDSISSYEAQITALKQERQQQQQ----------DCEEKERELGRLK----- 126
L+D I + Q L +ER+ ++ + EEK + L +LK
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 127 -------QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQE 179
+L LEK K D+ E + ++ +I ELK +L + EE +Q
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 180 IQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEE-LSGDGGPAAEAFAHNCDDSASISSFS 238
R + L R+ + L+E L + +A D + +
Sbjct: 1095 ALARLDD--EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 239 LGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTE 298
+ L + + +QE A T++ + + ++ ++
Sbjct: 1153 --------TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 299 GRQLQKDLESVSRER---DELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQA 355
+L + LE R + D+ ++ L + N D A +++VL Q E + L+ V +
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 356 Q------ERVQLQM------------------------------------AELVTTHKCL 373
Q ER + ++ ++L T + L
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 374 HHEVK-RLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTR---QEAR 429
E + +LN + + E+ +S +E +++L + L L ++ Q+
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 430 ARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME 489
+ ++A E G +R + EI L + EE+ A LE ++E + L L + R +
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 490 RVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQA-ETL 548
++++Q K LL+E++ + E + +E R+ + +L LE +A E L
Sbjct: 1445 NLEKKQRK--FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 549 EQVRSIMDEAPLTDVRDIKD 568
E+ ++ +A + D+ KD
Sbjct: 1503 ERTNKML-KAEMEDLVSSKD 1521
Score = 55.1 bits (131), Expect = 2e-07
Identities = 107/541 (19%), Positives = 229/541 (42%), Gaps = 91/541 (16%)
Query: 27 SQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASL 86
S G EAE G+ +L ++A ++++ + + + E+ + V+ RQ +EE SL
Sbjct: 1291 SVTGMLNEAE-GKAIKLAKDVASLSSQLQDTQELLQ-EETRQKLNVSTKLRQLEEERNSL 1348
Query: 87 QAILKDS----------ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLD 136
Q L + IS+ Q++ K++ Q E E R ++ ++
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK------EIE 1402
Query: 137 SLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTEL 196
+L +Q E+ +KL + +++E+++L L +L+ ++++ R L
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL------ 1456
Query: 197 LPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGL 256
L+ + + + D AEA A + A + +L + + L ++ + L
Sbjct: 1457 --LAEEKN-----ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 257 SPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDEL 316
E E+ LVS+ V + ++ +L+ R L+ +E + + +EL
Sbjct: 1510 KAEMED---LVSSKDDVGKNVH---------------ELEKSKRALETQMEEMKTQLEEL 1551
Query: 317 QEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHE 376
++ L+ + ED +++V + ++ Q R LQ Q +E+ + +L HE
Sbjct: 1552 EDELQ-ATEDAKLRLEVNMQALKG--QFERDLQARDEQNEEKRRQLQRQL--------HE 1600
Query: 377 VKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEARARLQAQE 436
+ E+ + RA A ++ +G+ + L ELQ A + ++ +E
Sbjct: 1601 YETELEDERKQRA-----LAAAAKKKLEGDLKDL-----ELQ---------ADSAIKGRE 1641
Query: 437 HGAERLR---IEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQ 493
++LR ++ + LE+ +R + + ++ + LEA L L+ ++ ++
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 494 EQSKAQL-PDLLSEQRAKVL----RLQAELETSE----QVQRDFVRLSQALQVRLERIRQ 544
+ +A L + L+E+ A L LQ E E Q++ + ++ +R+R+
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 545 A 545
A
Sbjct: 1762 A 1762
Score = 50.4 bits (119), Expect = 4e-06
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 12 DERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKA 69
DE+RR A LE+ +E N EA S + + + E+ T ++ A+ +ES +
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 70 EAVAA---VQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLK 126
+ ++ + E ++++ K +I++ EA+I L++ Q +Q+ EK+ LK
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLK 1845
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
Q + L + Q+E + +E+ +E +++LK +L AEE Q I R
Sbjct: 1846 Q---KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Score = 48.5 bits (114), Expect = 2e-05
Identities = 56/249 (22%), Positives = 109/249 (43%), Gaps = 40/249 (16%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q E++Q + +LQK E + +EL+E L + + ++ +L Q+Q +L
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELY----- 903
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEEN---QGLRAEQLPSSAPQGSQQEQGEE 407
++A+E A+ + LH RL EE Q L+AE+ + +EQ EE
Sbjct: 904 --AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 408 ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQL 467
E + AR +LQ ++ AE + LE+E + ++ Q
Sbjct: 962 E-----------------EAARQKLQLEKVTAE-------AKIKKLEDEILV---MDDQN 994
Query: 468 RVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRD 527
+E ++LE + L T + ++E+ L L ++ + + L+ L+ E+ +++
Sbjct: 995 NKLSKERKLLEERISDLTTNL--AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 528 FVRLSQALQ 536
+L + L+
Sbjct: 1053 LEKLKRKLE 1061
Score = 46.6 bits (109), Expect = 6e-05
Identities = 89/465 (19%), Positives = 177/465 (38%), Gaps = 90/465 (19%)
Query: 12 DERRRRPGAALEDSRSQ-EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
++ +R +E+ ++Q E E ++ E ++LR E+ M+ +K E + E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV-----NMQALKGQFERDLQARDE 1585
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQ-----ERQQQQQDCEEKERELGRL 125
+RQ Q ++ + L+D A K+ + + Q D K RE +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-I 1644
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
KQL + ++++E A +++ EK+ + L+A L++ +E + +R +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 186 HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
A LE EEL
Sbjct: 1705 QA------------------DLEK-EEL-------------------------------- 1713
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L S G + Q+E L + + E + + + D + Q + QL +
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ-QAEQLSNE 1772
Query: 306 L---ESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS-EQLLRTLQGTVSQAQERVQL 361
L S +++ + ++ L R N++ ++ + V++ + + L+ ++Q +E+V+
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 362 QMAELVTTHKCLHHEVKRLNE-----ENQGLRAEQLPSSAPQGS--------QQEQGEEE 408
+ E K L + K+L E E++ AEQ A +G+ Q E+ EEE
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREAL 453
S Q + R++ + L E + E+ L+ L
Sbjct: 1893 S---------QRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 40.8 bits (94), Expect = 0.003
Identities = 103/500 (20%), Positives = 192/500 (38%), Gaps = 94/500 (18%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R + AL +R+ E A E E + L+AE+ ++ + + K V E+ +S +A
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 70 --EAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQ 127
+ ++ Q +E LQA +D+ E + ALK + ++ Q +E+ E R Q
Sbjct: 1537 LETQMEEMKTQLEELEDELQAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 128 LLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIE-ELKAKLLRAEELIQEIQRRPRH 186
Y E ED K R + +K++E +LK L+A+ I+
Sbjct: 1596 RQLHEY---------ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-------- 1638
Query: 187 APSLHGSTELLPLSRDPSPPLEPLE-ELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
G E + R ++ + EL E FA ++ S
Sbjct: 1639 -----GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE------- 1686
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ L Q ++ L+ + +Q E +L ++
Sbjct: 1687 -ADLMQLQEDLAAAERAR-----------------------------KQADLEKEELAEE 1716
Query: 306 LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQLQMAE 365
L S R+ LQ+ RR A+ + L + N E + ++ QA E++ ++A
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA-EQLSNELAT 1775
Query: 366 LVTTHKCLHHEVKRLNEENQGLRAE------------------------QLPSSAPQGSQ 401
+T + ++L +N+ LR++ QL Q ++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 402 QEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEE-ETVAR 460
++Q +SL +L+++L E + Q +E AE+ + L+ LEE E ++
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ-AEKGNARVKQLKRQLEEAEEESQ 1894
Query: 461 ASLEGQLRVQREETEVLEAS 480
+ ++QRE E E++
Sbjct: 1895 RINANRRKLQRELDEATESN 1914
Score = 37.0 bits (84), Expect = 0.049
Identities = 38/153 (24%), Positives = 72/153 (47%), Gaps = 10/153 (6%)
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+++ LL TRQE +QA+E ++ + L+E + L + + +E+ +
Sbjct: 840 KVKPLLQVTRQEEE--MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 476 VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQA- 534
E L + EM RV+ K +L ++L E A RL+ E + +Q+Q + +++Q
Sbjct: 898 A-ETELYAEAEEM-RVRLAAKKQELEEILHEMEA---RLEEEEDRGQQLQAERKKMAQQM 952
Query: 535 --LQVRLERIRQAETLEQVRSIMDEAPLTDVRD 565
L+ +LE A Q+ + EA + + D
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 69.3 bits (168), Expect = 9e-12
Identities = 146/636 (22%), Positives = 252/636 (39%), Gaps = 105/636 (16%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAES--GELSRLRAELAGALAEMETMKAVAEVS 64
VA ++ER R E R++ EAE G L+ + EL ++E+E V E
Sbjct: 907 VAQLEEERAR----LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEE 960
Query: 65 ESTKA-------------------EAVAAVQRQCQEEVASLQAILK---DSISSYEAQIT 102
E ++ EA +++ Q E + +A +K + + E Q +
Sbjct: 961 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1020
Query: 103 ALKQERQ----------QQQQDCEEKERELGRLK------------QLLSRAYPLDSLEK 140
L +ER+ Q + EEK + L +L+ +L LEK
Sbjct: 1021 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1080
Query: 141 QMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLS 200
+ +S +L+E ++ ++ EEL+A+L R EE +Q R +LL
Sbjct: 1081 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG--ARAQLLKSL 1138
Query: 201 RDPSPPL-EPLEELSGDGGPAAEAFAHNCDDSASISSF--SLGGGVGSSSSLPQSRQGLS 257
R+ L E E+L + +A D + + L + S+++ + R
Sbjct: 1139 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1198
Query: 258 PEQEETASLVSTGTLVPE----------GIYLPPPGYQLVPDTQ----WEQ----LQTEG 299
E E + T + E G L QL + WE+ L+ E
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1258
Query: 300 RQLQKDLESVSRERDELQEGLRRSN----------EDCAKQMQVLLAQVQNSEQLLRTLQ 349
+L+ +L S+ R E ++ RR D + ++Q ++ L +
Sbjct: 1259 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVS 1318
Query: 350 GTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQ---GLRAEQLPSSAPQGSQQEQGE 406
G +++A+ + EL +T LH + L EE + L + A +EQ E
Sbjct: 1319 GALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1378
Query: 407 EES---------LPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEET 457
EE+ L ++ +L + +EA A L+A E R E L + L E+T
Sbjct: 1379 EEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-LEAGEEARRRAAREAEALTQRLAEKT 1437
Query: 458 VARASLE-GQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQ 515
LE G+ R+Q+E L+ + L + + V E+ + + LL+E++A VLR
Sbjct: 1438 ETVDRLERGRRRLQQE----LDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1493
Query: 516 AELETSEQVQRDFVRLSQALQVRLERIRQA-ETLEQ 550
E E +E R+ + +L LE ++A E LE+
Sbjct: 1494 EERERAEAEGREREARALSLTRALEEEQEAREELER 1529
Score = 66.2 bits (160), Expect = 7e-11
Identities = 110/507 (21%), Positives = 198/507 (39%), Gaps = 57/507 (11%)
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+ + + + V +Q+Q EV LQ ++ E + L ++ + + + C E E G
Sbjct: 881 ARAQELQKVQELQQQSAREVGELQG----RVAQLEEERARLAEQLRAEAELCAEAEETRG 936
Query: 124 RL---KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 180
RL KQ L + LE ++ + E S +++ +++ I+EL+A L E Q++
Sbjct: 937 RLAARKQELELV--VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 994
Query: 181 Q-RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL 239
Q + + E L L D + L +L D AE + ++ + S
Sbjct: 995 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED--RLAEFSSQAAEEEEKVKSL-- 1050
Query: 240 GGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEG 299
+ L + + E+ G E + G Q + Q
Sbjct: 1051 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1103
Query: 300 RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERV 359
+L+ L R+ +ELQ L R+ ++ + Q+L + LR Q +++AQE +
Sbjct: 1104 EELRAQL---GRKEEELQAALARAEDEGGARAQLL--------KSLREAQAALAEAQEDL 1152
Query: 360 QLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQ 419
+ + K + + L EE + LR E + +QQE + V EL++
Sbjct: 1153 ESERVARTKAEK----QRRDLGEELEALRGELEDTLDSTNAQQELRSKRE--QEVTELKK 1206
Query: 420 LLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEA 479
L +E R A + +R + L E LE+ + + E E L A
Sbjct: 1207 TL---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263
Query: 480 SLCSLRTEMERVQQEQSKAQL------------PDLLSEQRAKVLRLQAELE----TSEQ 523
L SL+T + +Q + + +L +E K+ R QAELE +
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1323
Query: 524 VQRDFVRLSQALQVRLERIRQAETLEQ 550
+ +RLS+ L ++ A+ L Q
Sbjct: 1324 AESKTIRLSKELSSTEAQLHDAQELLQ 1350
Score = 63.5 bits (153), Expect = 5e-10
Identities = 121/498 (24%), Positives = 191/498 (38%), Gaps = 79/498 (15%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R R AL +R+ E E E LRAEL L+ + + K+V E+ + +
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561
Query: 70 EAVAAVQRQCQ-EEVASLQAILKDSISSYEAQITALK--QERQQQQQDCEEKERELGRLK 126
AA + Q E+ +D+ E + ALK ER Q +D +ER K
Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRA----EELIQEIQR 182
QL D KQ A +KL E E+EELKA++ A EE ++++++
Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKL-------EGELEELKAQMASAGQGKEEAVKQLRK 1674
Query: 183 RPRHAPSLHGSTELLPLSRDP--SPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 240
L E SR+ S E + L G EA + + S
Sbjct: 1675 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKG-----LEAEVLRLQEELAASD---- 1725
Query: 241 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 300
++R+ +++E A V+ G L I E+ Q EGR
Sbjct: 1726 ----------RARRQAQQDRDEMADEVANGNLSKAAILE-------------EKRQLEGR 1762
Query: 301 --QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLL---RTLQGTVSQA 355
QL+++LE + L + R+ LL QV++ L R+
Sbjct: 1763 LGQLEEELEEEQSNSELLNDRYRK-----------LLLQVESLTTELSAERSFSAKAESG 1811
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+++++ Q+ EL RL EE+ G RA + A S+ Q EE+ +
Sbjct: 1812 RQQLERQIQELRG----------RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRE 1861
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+ R E R + + ER + LR+ LE+ + L+ QL EE
Sbjct: 1862 RILSGKLVRRAEKRLKEVVLQVEEERRVAD--QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1919
Query: 476 VLEASLCSLRTEMERVQQ 493
+A L+ E+E V +
Sbjct: 1920 RAQAGRRRLQRELEDVTE 1937
Score = 62.0 bits (149), Expect = 1e-09
Identities = 127/573 (22%), Positives = 229/573 (39%), Gaps = 74/573 (12%)
Query: 10 DDDERRRRPGAALED--SRSQEGANGEAESGE-LSRLRAEL---AGAL--AEMETMKAVA 61
+ ++RRRR L++ R+ +G AE+ E L R +AEL +GAL AE +T++
Sbjct: 1274 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1333
Query: 62 EVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERE 121
E+S ST+A+ A Q QEE + A L + + EA+ L+++ +++ E RE
Sbjct: 1334 ELS-STEAQLHDA-QELLQEETRAKLA-LGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1390
Query: 122 LGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
L + LS E +A E++ + +E E L +L E + ++
Sbjct: 1391 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA------REAEALTQRLAEKTETVDRLE 1444
Query: 182 RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGG 241
R G L D + LE +L E D + ++
Sbjct: 1445 R---------GRRRLQQELDDATMDLEQQRQLVS----TLEKKQRKFDQLLAEEKAAVLR 1491
Query: 242 GVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
V + R + E +L T L E E+L+ + R
Sbjct: 1492 AVEE-----RERAEAEGREREARALSLTRALEEE-------------QEAREELERQNRA 1533
Query: 302 LQKDLESVSRERDELQEGLRRSNEDCAKQMQV---LLAQVQNSEQLLRTLQGTVSQAQER 358
L+ +LE++ +D++ + + C Q L AQV E L + A+ R
Sbjct: 1534 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE----DAKLR 1589
Query: 359 VQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQ 418
+++ + L T H+ EE + A+QL + ++ E+ EE + +
Sbjct: 1590 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL-----RDAEVERDEERKQRTLAVAAR 1644
Query: 419 QLLCCTRQEARARLQAQEHGAE-------RLRIEIVTLREALEEETVARASLEGQLRVQR 471
+ L +E +A++ + G E +++ ++ L +EE +R + Q R
Sbjct: 1645 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1704
Query: 472 EETEVLEASLCSLRTEMERVQQEQSKAQ--LPDLLSEQRAKVLRLQAELETSEQVQRDFV 529
+ + LEA + L+ E+ + + +AQ ++ E L A LE Q++
Sbjct: 1705 KRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG 1764
Query: 530 RLSQALQ-----VRLERIRQAETLEQVRSIMDE 557
+L + L+ L R + L QV S+ E
Sbjct: 1765 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1797
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/270 (23%), Positives = 122/270 (45%), Gaps = 26/270 (9%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
QW +L T+ K L V+R+ + LQ A+++Q + Q S + + LQG
Sbjct: 858 QWWRLFTK----VKPLLQVTRQDEVLQAR--------AQELQKVQELQQQSAREVGELQG 905
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQ--GEEE 408
V+Q +E + ++AE + L E EE +G A + S+ E GEEE
Sbjct: 906 RVAQLEEE-RARLAEQLRAEAELCAEA----EETRGRLAARKQELELVVSELEARVGEEE 960
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
+ ++ L QE A L+A+E ++L++E VT +++ LE Q
Sbjct: 961 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1020
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528
+E ++LE L + + ++E+ L L + A + ++ L E+ +++
Sbjct: 1021 KLSKERKLLEDRLAEFSS--QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1078
Query: 529 VRLSQAL-----QVRLERIRQAETLEQVRS 553
+L + L +++ + + Q + E++R+
Sbjct: 1079 EKLKRRLDGESSELQEQMVEQQQRAEELRA 1108
Score = 41.2 bits (95), Expect = 0.003
Identities = 45/244 (18%), Positives = 105/244 (43%), Gaps = 29/244 (11%)
Query: 8 AADDDERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSE 65
AA +E+R+ G LE+ +E +N E + +L ++ E+ ++ + +E
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1809
Query: 66 STKAEAVAAVQR---QCQEEVASLQAILKDSISSYEAQITALKQERQQQQQD-------- 114
S + + +Q + EE A +A K +I++ E+++ +++ +Q+ ++
Sbjct: 1810 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1869
Query: 115 -------------CEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKLREIVLPME 160
EE+ R +L+ L + + L++Q+E+A E++ + + ++
Sbjct: 1870 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1929
Query: 161 KEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSR--DPSPPLEPLEELSGDGG 218
+E+E++ + ++ R R P + + + R + E EE G
Sbjct: 1930 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 1989
Query: 219 PAAE 222
P+ E
Sbjct: 1990 PSPE 1993
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 69.3 bits (168), Expect = 9e-12
Identities = 146/636 (22%), Positives = 252/636 (39%), Gaps = 105/636 (16%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAES--GELSRLRAELAGALAEMETMKAVAEVS 64
VA ++ER R E R++ EAE G L+ + EL ++E+E V E
Sbjct: 899 VAQLEEERAR----LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEE 952
Query: 65 ESTKA-------------------EAVAAVQRQCQEEVASLQAILK---DSISSYEAQIT 102
E ++ EA +++ Q E + +A +K + + E Q +
Sbjct: 953 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1012
Query: 103 ALKQERQ----------QQQQDCEEKERELGRLK------------QLLSRAYPLDSLEK 140
L +ER+ Q + EEK + L +L+ +L LEK
Sbjct: 1013 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1072
Query: 141 QMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLS 200
+ +S +L+E ++ ++ EEL+A+L R EE +Q R +LL
Sbjct: 1073 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG--ARAQLLKSL 1130
Query: 201 RDPSPPL-EPLEELSGDGGPAAEAFAHNCDDSASISSF--SLGGGVGSSSSLPQSRQGLS 257
R+ L E E+L + +A D + + L + S+++ + R
Sbjct: 1131 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1190
Query: 258 PEQEETASLVSTGTLVPE----------GIYLPPPGYQLVPDTQ----WEQ----LQTEG 299
E E + T + E G L QL + WE+ L+ E
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1250
Query: 300 RQLQKDLESVSRERDELQEGLRRSN----------EDCAKQMQVLLAQVQNSEQLLRTLQ 349
+L+ +L S+ R E ++ RR D + ++Q ++ L +
Sbjct: 1251 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVS 1310
Query: 350 GTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQ---GLRAEQLPSSAPQGSQQEQGE 406
G +++A+ + EL +T LH + L EE + L + A +EQ E
Sbjct: 1311 GALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1370
Query: 407 EES---------LPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEET 457
EE+ L ++ +L + +EA A L+A E R E L + L E+T
Sbjct: 1371 EEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-LEAGEEARRRAAREAEALTQRLAEKT 1429
Query: 458 VARASLE-GQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQ 515
LE G+ R+Q+E L+ + L + + V E+ + + LL+E++A VLR
Sbjct: 1430 ETVDRLERGRRRLQQE----LDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1485
Query: 516 AELETSEQVQRDFVRLSQALQVRLERIRQA-ETLEQ 550
E E +E R+ + +L LE ++A E LE+
Sbjct: 1486 EERERAEAEGREREARALSLTRALEEEQEAREELER 1521
Score = 66.2 bits (160), Expect = 7e-11
Identities = 110/507 (21%), Positives = 198/507 (39%), Gaps = 57/507 (11%)
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+ + + + V +Q+Q EV LQ ++ E + L ++ + + + C E E G
Sbjct: 873 ARAQELQKVQELQQQSAREVGELQG----RVAQLEEERARLAEQLRAEAELCAEAEETRG 928
Query: 124 RL---KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 180
RL KQ L + LE ++ + E S +++ +++ I+EL+A L E Q++
Sbjct: 929 RLAARKQELELV--VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 986
Query: 181 Q-RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL 239
Q + + E L L D + L +L D AE + ++ + S
Sbjct: 987 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED--RLAEFSSQAAEEEEKVKSL-- 1042
Query: 240 GGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEG 299
+ L + + E+ G E + G Q + Q
Sbjct: 1043 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1095
Query: 300 RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERV 359
+L+ L R+ +ELQ L R+ ++ + Q+L + LR Q +++AQE +
Sbjct: 1096 EELRAQL---GRKEEELQAALARAEDEGGARAQLL--------KSLREAQAALAEAQEDL 1144
Query: 360 QLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQ 419
+ + K + + L EE + LR E + +QQE + V EL++
Sbjct: 1145 ESERVARTKAEK----QRRDLGEELEALRGELEDTLDSTNAQQELRSKRE--QEVTELKK 1198
Query: 420 LLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEA 479
L +E R A + +R + L E LE+ + + E E L A
Sbjct: 1199 TL---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255
Query: 480 SLCSLRTEMERVQQEQSKAQL------------PDLLSEQRAKVLRLQAELE----TSEQ 523
L SL+T + +Q + + +L +E K+ R QAELE +
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1315
Query: 524 VQRDFVRLSQALQVRLERIRQAETLEQ 550
+ +RLS+ L ++ A+ L Q
Sbjct: 1316 AESKTIRLSKELSSTEAQLHDAQELLQ 1342
Score = 63.5 bits (153), Expect = 5e-10
Identities = 121/498 (24%), Positives = 191/498 (38%), Gaps = 79/498 (15%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R R AL +R+ E E E LRAEL L+ + + K+V E+ + +
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553
Query: 70 EAVAAVQRQCQ-EEVASLQAILKDSISSYEAQITALK--QERQQQQQDCEEKERELGRLK 126
AA + Q E+ +D+ E + ALK ER Q +D +ER K
Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRA----EELIQEIQR 182
QL D KQ A +KL E E+EELKA++ A EE ++++++
Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKL-------EGELEELKAQMASAGQGKEEAVKQLRK 1666
Query: 183 RPRHAPSLHGSTELLPLSRDP--SPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 240
L E SR+ S E + L G EA + + S
Sbjct: 1667 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKG-----LEAEVLRLQEELAASD---- 1717
Query: 241 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 300
++R+ +++E A V+ G L I E+ Q EGR
Sbjct: 1718 ----------RARRQAQQDRDEMADEVANGNLSKAAILE-------------EKRQLEGR 1754
Query: 301 --QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLL---RTLQGTVSQA 355
QL+++LE + L + R+ LL QV++ L R+
Sbjct: 1755 LGQLEEELEEEQSNSELLNDRYRK-----------LLLQVESLTTELSAERSFSAKAESG 1803
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+++++ Q+ EL RL EE+ G RA + A S+ Q EE+ +
Sbjct: 1804 RQQLERQIQELRG----------RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRE 1853
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+ R E R + + ER + LR+ LE+ + L+ QL EE
Sbjct: 1854 RILSGKLVRRAEKRLKEVVLQVEEERRVAD--QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1911
Query: 476 VLEASLCSLRTEMERVQQ 493
+A L+ E+E V +
Sbjct: 1912 RAQAGRRRLQRELEDVTE 1929
Score = 62.0 bits (149), Expect = 1e-09
Identities = 127/573 (22%), Positives = 229/573 (39%), Gaps = 74/573 (12%)
Query: 10 DDDERRRRPGAALED--SRSQEGANGEAESGE-LSRLRAEL---AGAL--AEMETMKAVA 61
+ ++RRRR L++ R+ +G AE+ E L R +AEL +GAL AE +T++
Sbjct: 1266 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1325
Query: 62 EVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERE 121
E+S ST+A+ A Q QEE + A L + + EA+ L+++ +++ E RE
Sbjct: 1326 ELS-STEAQLHDA-QELLQEETRAKLA-LGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1382
Query: 122 LGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
L + LS E +A E++ + +E E L +L E + ++
Sbjct: 1383 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA------REAEALTQRLAEKTETVDRLE 1436
Query: 182 RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGG 241
R G L D + LE +L E D + ++
Sbjct: 1437 R---------GRRRLQQELDDATMDLEQQRQLVS----TLEKKQRKFDQLLAEEKAAVLR 1483
Query: 242 GVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
V + R + E +L T L E E+L+ + R
Sbjct: 1484 AVEE-----RERAEAEGREREARALSLTRALEEE-------------QEAREELERQNRA 1525
Query: 302 LQKDLESVSRERDELQEGLRRSNEDCAKQMQV---LLAQVQNSEQLLRTLQGTVSQAQER 358
L+ +LE++ +D++ + + C Q L AQV E L + A+ R
Sbjct: 1526 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE----DAKLR 1581
Query: 359 VQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQ 418
+++ + L T H+ EE + A+QL + ++ E+ EE + +
Sbjct: 1582 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL-----RDAEVERDEERKQRTLAVAAR 1636
Query: 419 QLLCCTRQEARARLQAQEHGAE-------RLRIEIVTLREALEEETVARASLEGQLRVQR 471
+ L +E +A++ + G E +++ ++ L +EE +R + Q R
Sbjct: 1637 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1696
Query: 472 EETEVLEASLCSLRTEMERVQQEQSKAQ--LPDLLSEQRAKVLRLQAELETSEQVQRDFV 529
+ + LEA + L+ E+ + + +AQ ++ E L A LE Q++
Sbjct: 1697 KRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG 1756
Query: 530 RLSQALQ-----VRLERIRQAETLEQVRSIMDE 557
+L + L+ L R + L QV S+ E
Sbjct: 1757 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1789
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/270 (23%), Positives = 122/270 (45%), Gaps = 26/270 (9%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
QW +L T+ K L V+R+ + LQ A+++Q + Q S + + LQG
Sbjct: 850 QWWRLFTK----VKPLLQVTRQDEVLQAR--------AQELQKVQELQQQSAREVGELQG 897
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQ--GEEE 408
V+Q +E + ++AE + L E EE +G A + S+ E GEEE
Sbjct: 898 RVAQLEEE-RARLAEQLRAEAELCAEA----EETRGRLAARKQELELVVSELEARVGEEE 952
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
+ ++ L QE A L+A+E ++L++E VT +++ LE Q
Sbjct: 953 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1012
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528
+E ++LE L + + ++E+ L L + A + ++ L E+ +++
Sbjct: 1013 KLSKERKLLEDRLAEFSS--QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1070
Query: 529 VRLSQAL-----QVRLERIRQAETLEQVRS 553
+L + L +++ + + Q + E++R+
Sbjct: 1071 EKLKRRLDGESSELQEQMVEQQQRAEELRA 1100
Score = 41.2 bits (95), Expect = 0.003
Identities = 45/244 (18%), Positives = 105/244 (43%), Gaps = 29/244 (11%)
Query: 8 AADDDERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSE 65
AA +E+R+ G LE+ +E +N E + +L ++ E+ ++ + +E
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1801
Query: 66 STKAEAVAAVQR---QCQEEVASLQAILKDSISSYEAQITALKQERQQQQQD-------- 114
S + + +Q + EE A +A K +I++ E+++ +++ +Q+ ++
Sbjct: 1802 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1861
Query: 115 -------------CEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKLREIVLPME 160
EE+ R +L+ L + + L++Q+E+A E++ + + ++
Sbjct: 1862 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1921
Query: 161 KEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSR--DPSPPLEPLEELSGDGG 218
+E+E++ + ++ R R P + + + R + E EE G
Sbjct: 1922 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 1981
Query: 219 PAAE 222
P+ E
Sbjct: 1982 PSPE 1985
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 69.3 bits (168), Expect = 9e-12
Identities = 146/636 (22%), Positives = 252/636 (39%), Gaps = 105/636 (16%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAES--GELSRLRAELAGALAEMETMKAVAEVS 64
VA ++ER R E R++ EAE G L+ + EL ++E+E V E
Sbjct: 940 VAQLEEERAR----LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEE 993
Query: 65 ESTKA-------------------EAVAAVQRQCQEEVASLQAILK---DSISSYEAQIT 102
E ++ EA +++ Q E + +A +K + + E Q +
Sbjct: 994 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1053
Query: 103 ALKQERQ----------QQQQDCEEKERELGRLK------------QLLSRAYPLDSLEK 140
L +ER+ Q + EEK + L +L+ +L LEK
Sbjct: 1054 KLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK 1113
Query: 141 QMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLS 200
+ +S +L+E ++ ++ EEL+A+L R EE +Q R +LL
Sbjct: 1114 LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG--ARAQLLKSL 1171
Query: 201 RDPSPPL-EPLEELSGDGGPAAEAFAHNCDDSASISSF--SLGGGVGSSSSLPQSRQGLS 257
R+ L E E+L + +A D + + L + S+++ + R
Sbjct: 1172 REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKRE 1231
Query: 258 PEQEETASLVSTGTLVPE----------GIYLPPPGYQLVPDTQ----WEQ----LQTEG 299
E E + T + E G L QL + WE+ L+ E
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1291
Query: 300 RQLQKDLESVSRERDELQEGLRRSN----------EDCAKQMQVLLAQVQNSEQLLRTLQ 349
+L+ +L S+ R E ++ RR D + ++Q ++ L +
Sbjct: 1292 SELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVS 1351
Query: 350 GTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQ---GLRAEQLPSSAPQGSQQEQGE 406
G +++A+ + EL +T LH + L EE + L + A +EQ E
Sbjct: 1352 GALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLE 1411
Query: 407 EES---------LPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEET 457
EE+ L ++ +L + +EA A L+A E R E L + L E+T
Sbjct: 1412 EEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-LEAGEEARRRAAREAEALTQRLAEKT 1470
Query: 458 VARASLE-GQLRVQREETEVLEASLCSLRTEMERVQQ-EQSKAQLPDLLSEQRAKVLRLQ 515
LE G+ R+Q+E L+ + L + + V E+ + + LL+E++A VLR
Sbjct: 1471 ETVDRLERGRRRLQQE----LDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1526
Query: 516 AELETSEQVQRDFVRLSQALQVRLERIRQA-ETLEQ 550
E E +E R+ + +L LE ++A E LE+
Sbjct: 1527 EERERAEAEGREREARALSLTRALEEEQEAREELER 1562
Score = 66.2 bits (160), Expect = 7e-11
Identities = 110/507 (21%), Positives = 198/507 (39%), Gaps = 57/507 (11%)
Query: 64 SESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELG 123
+ + + + V +Q+Q EV LQ ++ E + L ++ + + + C E E G
Sbjct: 914 ARAQELQKVQELQQQSAREVGELQG----RVAQLEEERARLAEQLRAEAELCAEAEETRG 969
Query: 124 RL---KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEI 180
RL KQ L + LE ++ + E S +++ +++ I+EL+A L E Q++
Sbjct: 970 RLAARKQELELV--VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 1027
Query: 181 Q-RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSL 239
Q + + E L L D + L +L D AE + ++ + S
Sbjct: 1028 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED--RLAEFSSQAAEEEEKVKSL-- 1083
Query: 240 GGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEG 299
+ L + + E+ G E + G Q + Q
Sbjct: 1084 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1136
Query: 300 RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERV 359
+L+ L R+ +ELQ L R+ ++ + Q+L + LR Q +++AQE +
Sbjct: 1137 EELRAQL---GRKEEELQAALARAEDEGGARAQLL--------KSLREAQAALAEAQEDL 1185
Query: 360 QLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQ 419
+ + K + + L EE + LR E + +QQE + V EL++
Sbjct: 1186 ESERVARTKAEK----QRRDLGEELEALRGELEDTLDSTNAQQELRSKRE--QEVTELKK 1239
Query: 420 LLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEA 479
L +E R A + +R + L E LE+ + + E E L A
Sbjct: 1240 TL---EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296
Query: 480 SLCSLRTEMERVQQEQSKAQL------------PDLLSEQRAKVLRLQAELE----TSEQ 523
L SL+T + +Q + + +L +E K+ R QAELE +
Sbjct: 1297 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1356
Query: 524 VQRDFVRLSQALQVRLERIRQAETLEQ 550
+ +RLS+ L ++ A+ L Q
Sbjct: 1357 AESKTIRLSKELSSTEAQLHDAQELLQ 1383
Score = 63.5 bits (153), Expect = 5e-10
Identities = 121/498 (24%), Positives = 191/498 (38%), Gaps = 79/498 (15%)
Query: 13 ERRRRPGAALEDSRSQEGANGEAESGELSR--LRAELAGALAEMETM-KAVAEVSESTKA 69
E R R AL +R+ E E E LRAEL L+ + + K+V E+ + +
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594
Query: 70 EAVAAVQRQCQ-EEVASLQAILKDSISSYEAQITALK--QERQQQQQDCEEKERELGRLK 126
AA + Q E+ +D+ E + ALK ER Q +D +ER K
Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654
Query: 127 QLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRA----EELIQEIQR 182
QL D KQ A +KL E E+EELKA++ A EE ++++++
Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKL-------EGELEELKAQMASAGQGKEEAVKQLRK 1707
Query: 183 RPRHAPSLHGSTELLPLSRDP--SPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLG 240
L E SR+ S E + L G EA + + S
Sbjct: 1708 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKG-----LEAEVLRLQEELAASD---- 1758
Query: 241 GGVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGR 300
++R+ +++E A V+ G L I E+ Q EGR
Sbjct: 1759 ----------RARRQAQQDRDEMADEVANGNLSKAAILE-------------EKRQLEGR 1795
Query: 301 --QLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLL---RTLQGTVSQA 355
QL+++LE + L + R+ LL QV++ L R+
Sbjct: 1796 LGQLEEELEEEQSNSELLNDRYRK-----------LLLQVESLTTELSAERSFSAKAESG 1844
Query: 356 QERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVP 415
+++++ Q+ EL RL EE+ G RA + A S+ Q EE+ +
Sbjct: 1845 RQQLERQIQELRG----------RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRE 1894
Query: 416 ELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETE 475
+ R E R + + ER + LR+ LE+ + L+ QL EE
Sbjct: 1895 RILSGKLVRRAEKRLKEVVLQVEEERRVAD--QLRDQLEKGNLRVKQLKRQLEEAEEEAS 1952
Query: 476 VLEASLCSLRTEMERVQQ 493
+A L+ E+E V +
Sbjct: 1953 RAQAGRRRLQRELEDVTE 1970
Score = 62.0 bits (149), Expect = 1e-09
Identities = 127/573 (22%), Positives = 229/573 (39%), Gaps = 74/573 (12%)
Query: 10 DDDERRRRPGAALED--SRSQEGANGEAESGE-LSRLRAEL---AGAL--AEMETMKAVA 61
+ ++RRRR L++ R+ +G AE+ E L R +AEL +GAL AE +T++
Sbjct: 1307 EGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1366
Query: 62 EVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERE 121
E+S ST+A+ A Q QEE + A L + + EA+ L+++ +++ E RE
Sbjct: 1367 ELS-STEAQLHDA-QELLQEETRAKLA-LGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1423
Query: 122 LGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
L + LS E +A E++ + +E E L +L E + ++
Sbjct: 1424 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAA------REAEALTQRLAEKTETVDRLE 1477
Query: 182 RRPRHAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGG 241
R G L D + LE +L E D + ++
Sbjct: 1478 R---------GRRRLQQELDDATMDLEQQRQLVS----TLEKKQRKFDQLLAEEKAAVLR 1524
Query: 242 GVGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQ 301
V + R + E +L T L E E+L+ + R
Sbjct: 1525 AVEE-----RERAEAEGREREARALSLTRALEEE-------------QEAREELERQNRA 1566
Query: 302 LQKDLESVSRERDELQEGLRRSNEDCAKQMQV---LLAQVQNSEQLLRTLQGTVSQAQER 358
L+ +LE++ +D++ + + C Q L AQV E L + A+ R
Sbjct: 1567 LRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE----DAKLR 1622
Query: 359 VQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQ 418
+++ + L T H+ EE + A+QL + ++ E+ EE + +
Sbjct: 1623 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL-----RDAEVERDEERKQRTLAVAAR 1677
Query: 419 QLLCCTRQEARARLQAQEHGAE-------RLRIEIVTLREALEEETVARASLEGQLRVQR 471
+ L +E +A++ + G E +++ ++ L +EE +R + Q R
Sbjct: 1678 KKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESE 1737
Query: 472 EETEVLEASLCSLRTEMERVQQEQSKAQ--LPDLLSEQRAKVLRLQAELETSEQVQRDFV 529
+ + LEA + L+ E+ + + +AQ ++ E L A LE Q++
Sbjct: 1738 KRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLG 1797
Query: 530 RLSQALQ-----VRLERIRQAETLEQVRSIMDE 557
+L + L+ L R + L QV S+ E
Sbjct: 1798 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1830
Score = 50.1 bits (118), Expect = 6e-06
Identities = 63/270 (23%), Positives = 122/270 (45%), Gaps = 26/270 (9%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
QW +L T+ K L V+R+ + LQ A+++Q + Q S + + LQG
Sbjct: 891 QWWRLFTK----VKPLLQVTRQDEVLQAR--------AQELQKVQELQQQSAREVGELQG 938
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQ--GEEE 408
V+Q +E + ++AE + L E EE +G A + S+ E GEEE
Sbjct: 939 RVAQLEEE-RARLAEQLRAEAELCAEA----EETRGRLAARKQELELVVSELEARVGEEE 993
Query: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468
+ ++ L QE A L+A+E ++L++E VT +++ LE Q
Sbjct: 994 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNS 1053
Query: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528
+E ++LE L + + ++E+ L L + A + ++ L E+ +++
Sbjct: 1054 KLSKERKLLEDRLAEFSS--QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1111
Query: 529 VRLSQAL-----QVRLERIRQAETLEQVRS 553
+L + L +++ + + Q + E++R+
Sbjct: 1112 EKLKRRLDGESSELQEQMVEQQQRAEELRA 1141
Score = 41.2 bits (95), Expect = 0.003
Identities = 45/244 (18%), Positives = 105/244 (43%), Gaps = 29/244 (11%)
Query: 8 AADDDERRRRPG--AALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSE 65
AA +E+R+ G LE+ +E +N E + +L ++ E+ ++ + +E
Sbjct: 1783 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAE 1842
Query: 66 STKAEAVAAVQR---QCQEEVASLQAILKDSISSYEAQITALKQERQQQQQD-------- 114
S + + +Q + EE A +A K +I++ E+++ +++ +Q+ ++
Sbjct: 1843 SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1902
Query: 115 -------------CEEKERELGRLKQLLSRA-YPLDSLEKQMEKAHEDSEKLREIVLPME 160
EE+ R +L+ L + + L++Q+E+A E++ + + ++
Sbjct: 1903 RRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQ 1962
Query: 161 KEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSR--DPSPPLEPLEELSGDGG 218
+E+E++ + ++ R R P + + + R + E EE G
Sbjct: 1963 RELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 2022
Query: 219 PAAE 222
P+ E
Sbjct: 2023 PSPE 2026
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 68.9 bits (167), Expect = 1e-11
Identities = 121/550 (22%), Positives = 220/550 (40%), Gaps = 87/550 (15%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDS 93
E+E ++ + E+E +K E + T A A ++ + ++EVA L+ L++
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA-AQQELRTKREQEVAELKKALEEE 1186
Query: 94 ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLEKQMEKAHEDSEKLR 153
++EAQI ++Q ++ E+ + R K +LEK + D+++L
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA---------NLEKNKQGLETDNKELA 1237
Query: 154 EIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELLPLSRDPSPPLEPLEEL 213
V +++ E + K + + +QE+ HA G + L+ S L+ +
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQEL-----HAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 214 SGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTGTLV 273
S A + D+AS+ S L +++ L QEET ++ + +
Sbjct: 1293 STLLEEAEKKGIKFAKDAASL-----------ESQLQDTQELL---QEETRQKLNLSSRI 1338
Query: 274 PEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQE---GLRRSNEDCAKQ 330
QL+ E LQ+ E R L++ L+ D K+
Sbjct: 1339 -------------------RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 331 MQVLLAQVQNSEQLLRTL---QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGL 387
+ L +++ E+ + L +SQ E L +L T L E+ L +
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 388 RAEQLPSSAPQGSQ---QEQGEEESLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRI 444
R Q+ S+ + + Q EE+S+ + E + RA +A+E + L
Sbjct: 1440 R--QVASNLEKKQKKFDQLLAEEKSISARYAE---------ERDRAEAEAREKETKAL-- 1486
Query: 445 EIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLL 504
+L ALEE A+ E Q + R + E L +S + + + E+SK L +
Sbjct: 1487 ---SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL--EKSKRALEQQV 1541
Query: 505 SEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAE----------TLEQVRSI 554
E R ++ L+ EL+ +E + QA++ + ER Q ++QVR +
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVREL 1601
Query: 555 MDEAPLTDVR 564
EA L D R
Sbjct: 1602 --EAELEDER 1609
Score = 65.1 bits (157), Expect = 2e-10
Identities = 110/594 (18%), Positives = 240/594 (40%), Gaps = 71/594 (11%)
Query: 23 EDSRSQ----EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQ 78
E+ R+Q E +A +L E GA +++ K AE E + ++ Q
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 79 CQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYPL-DS 137
+ + + +++D I+ +Q+ +++ + + ++E + L++ L +
Sbjct: 994 NSKFIKE-KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052
Query: 138 LEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPRHAPSLHGSTELL 197
LEK K ++ L++ + ++ +I+ELK +L + EE +Q R +LH + L
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR-GDDETLHKNNALK 1111
Query: 198 PLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPQSRQGLS 257
+ + E E+ + +A D S + + + L + +
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL--------KTELEDTLDTTA 1163
Query: 258 PEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKDLESVSRERDELQ 317
+QE + + + ++ ++ T +L + LE R + L+
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223
Query: 318 ---EGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQ------ERVQLQMAE--- 365
+GL N++ A +++VL SE + L V + +R+++++AE
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 366 ---------------------------------LVTTHKCLHHEVK-RLNEENQGLRAEQ 391
L T + L E + +LN ++ + E+
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 392 LPSSAPQGSQQEQGEEESLPSSVPELQQLLCCTRQEA---RARLQAQEHGAERLRIEIVT 448
+S + ++E+ ++L V LQ L T+++ +++ E ++L +
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 449 LREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQR 508
L + LEE+ +A LE ++E + L L R ++++Q K LL+E++
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK--FDQLLAEEK 1461
Query: 509 AKVLRLQAELETSEQVQRD----FVRLSQALQVRLERIRQAETL-EQVRSIMDE 557
+ R E + +E R+ + L++AL+ LE + E +Q+R+ M++
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Score = 64.3 bits (155), Expect = 3e-10
Identities = 111/545 (20%), Positives = 236/545 (43%), Gaps = 70/545 (12%)
Query: 7 VAADDDERRRRPGAALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSES 66
V A+ + +R++ A +++ ++ + G+ EL+ ++L L + T+ AE
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKV-SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 67 TKAEAVAAVQRQCQEEVASLQAILKD--SISSYEAQITALKQERQQQQQDCEEKERELGR 124
A+ A+++ Q Q+ LQ + ++SS Q+ K Q+QQ++ EE + L
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE- 1363
Query: 125 LKQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLR-AEELIQEIQRR 183
KQ+L+ L+ Q+ D++K + L + +EE K KLL+ AE L Q ++ +
Sbjct: 1364 -KQVLA-------LQSQLA----DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 184 PRHAPSLHGSTELLPLSRDP-SPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGG 242
L + L D + L+ +++ + + F + SIS+
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA------ 1465
Query: 243 VGSSSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQL 302
+ + R ++ET +L S + E + E+ + + +QL
Sbjct: 1466 ---RYAEERDRAEAEAREKETKAL-SLARALEEALEAK------------EEFERQNKQL 1509
Query: 303 QKDLESVSRERDELQEG---LRRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERV 359
+ D+E + +D++ + L +S +Q++ + Q++ E L+ + + + +
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 360 QLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESLPSSVPELQQ 419
Q A+ + + NEE + L +Q+ + + E+ + +S +++
Sbjct: 1570 QAMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAE-LEDERKQRALAVASKKKMEI 1624
Query: 420 LLCCTRQEARARLQAQEHGAERLR---IEIVTLREALEEETVARASLEGQLRVQREETEV 476
L + A +A++ ++LR ++ + LEE +R + Q + ++ +
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 477 LEASLCSLRTEM---ERVQQ--EQSKAQLPD-----------LLSEQR---AKVLRLQAE 517
LEA + L+ E+ ER ++ EQ + +L D LL E+R A++ +L+ E
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 518 LETSE 522
LE +
Sbjct: 1745 LEEEQ 1749
Score = 55.8 bits (133), Expect = 1e-07
Identities = 99/510 (19%), Positives = 196/510 (38%), Gaps = 88/510 (17%)
Query: 12 DERRRRPGAALEDSRSQ-EGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAE 70
++ +R +E+ R+Q E E ++ E ++LR E+ M+ MKA E T+ E
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV-----NMQAMKAQFERDLQTRDE 1585
Query: 71 AVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGR-----L 125
+R ++V L+A L+D A A K++ + +D E + + +
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDE-RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI 1644
Query: 126 KQLLSRAYPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPR 185
KQL + ++++E+A +++ EK+++ L+A++L+ +E + +R R
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704
Query: 186 HAPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGS 245
HA + A +SAS S L
Sbjct: 1705 HAEQ------------------------------ERDELADEITNSASGKSALLDEKRRL 1734
Query: 246 SSSLPQSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQTEGRQLQKD 305
+ + Q + L EQ L L DT +L E
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKT-----------TLQVDTLNAELAAE------- 1776
Query: 306 LESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNS-EQLLRTLQGTVSQAQERVQLQMA 364
S +++ D ++ L R N++ ++Q L V++ + + L+ + Q +E+++ +
Sbjct: 1777 -RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 365 ELVTTHKCLHHEVKRLNE-----ENQGLRAEQLPSSAPQGS--------QQEQGEEESLP 411
E +K + K+L E E++ A+Q + + Q E+ EEE+
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 412 SSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEE----ETVARASLEGQL 467
++ +R++ + L E L E+ TL+ L + S QL
Sbjct: 1896 AN---------ASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQL 1946
Query: 468 RVQREETEVLEASLCSLRTEMERVQQEQSK 497
++ E+ + S +++ Q QS+
Sbjct: 1947 HLEGASLELSDDDTESKTSDVNETQPPQSE 1976
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/312 (22%), Positives = 128/312 (41%), Gaps = 33/312 (10%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNE------DCAKQMQV----------- 333
Q E+LQ + +L K E ++ EL+E R+ + A+Q+Q
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 334 ---LLAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAE 390
L A+ Q E++L L+ V + +ER Q+ E + ++L+EE +
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 391 QLPSSAPQGSQQEQGEE----ESLPSSVPELQQLLCCTRQEARARLQAQEHGAERL---- 442
QL + ++ EE E S + ++L+ E ++L +E A+ L
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIR 1029
Query: 443 ---RIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTEME--RVQQEQSK 497
+ I L E L++E R LE R ET L+ + L+ +++ ++Q + +
Sbjct: 1030 NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 498 AQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVRSIMDE 557
+L L+ + L L+ ++Q L + + +AE ++ S E
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 558 APLTDVRDIKDT 569
A T++ D DT
Sbjct: 1150 ALKTELEDTLDT 1161
Score = 48.9 bits (115), Expect = 1e-05
Identities = 63/285 (22%), Positives = 123/285 (43%), Gaps = 64/285 (22%)
Query: 291 QWEQLQTEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTLQG 350
Q +LQ + + Q++LE RDE + AQ + SE+ L++L+
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDE------------------IFAQSKESEKKLKSLEA 1687
Query: 351 TVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEESL 410
+ Q QE EL ++ + H E+ + A+++ +SA G E+ L
Sbjct: 1688 EILQLQE-------ELASSERARRHA-----EQERDELADEITNSA-SGKSALLDEKRRL 1734
Query: 411 PSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTL-------REALEEETVARASL 463
+ + +L++ L +E ++ ++ + +++ TL R A ++ AR L
Sbjct: 1735 EARIAQLEEEL----EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 464 EGQ---LRVQREETE------------VLEASLCSLRTEMERVQQEQSKAQLPDLLSEQR 508
E Q L+ + +E E LEA + L ++E+ +E++ A +E++
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 509 AKVLRLQAELET------SEQVQRDFVRLSQALQVRLERIRQAET 547
K + +Q E E EQ+++ R+ Q L+ +LE + T
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQ-LKRQLEEAEEEAT 1894
Score = 37.0 bits (84), Expect = 0.049
Identities = 51/204 (25%), Positives = 92/204 (45%), Gaps = 36/204 (17%)
Query: 11 DDERRRRPGAA---------LEDSRSQEGANGEAESG---ELSRLRAELAGALAEMETMK 58
+DER++R A L+D +Q A +A +L +L+A++ E+E +
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR 1665
Query: 59 A-----VAEVSESTKA-EAVAAVQRQCQEEVASLQAI----------LKDSISSYEAQIT 102
A A+ ES K +++ A Q QEE+AS + L D I++ + +
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKS 1725
Query: 103 ALKQERQQQQ----QDCEEKERELGRLKQLLSR----AYPLDSLEKQMEKAHEDSEKLRE 154
AL E+++ + Q EE E E ++ L R +D+L ++ ++K
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 155 IVLPMEKEIEELKAKLLRAEELIQ 178
+E++ +ELKAKL E ++
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVK 1809
Score = 32.3 bits (72), Expect = 1.2
Identities = 34/153 (22%), Positives = 66/153 (43%), Gaps = 19/153 (12%)
Query: 34 EAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDS 93
+A+ EL +++ + E+E M+ + + + + + A Q Q + E+ +
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQ--QLLEEKNILAEQLQAETELFA-------E 905
Query: 94 ISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAYP-----LDSLEKQMEKAHED 148
A++ A KQE ++ D E + E Q+L + LE+Q+++
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 149 SEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181
+KL+ +EK E K K + E L+ E Q
Sbjct: 966 RQKLQ-----LEKVTAEAKIKKMEEEILLLEDQ 993
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.326
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,517,833
Number of Sequences: 37866
Number of extensions: 998933
Number of successful extensions: 13312
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 7122
Number of HSP's gapped (non-prelim): 5070
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.