Search of human proteins with 10863975

Search of human proteins with 10863975

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10863975 islet-specific glucose-6-phosphatase-related
protein isoform 1 [Homo sapiens]
         (355 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10863975 islet-specific glucose-6-phosphatase-related protein...   746   0.0  
gi|4557599 glucose-6-phosphatase, catalytic subunit [Homo sapiens]    373   e-103
gi|126273546 islet-specific glucose-6-phosphatase-related protei...   324   6e-89
gi|24308434 glucose-6-phosphatase catalytic subunit 3 [Homo sapi...   215   6e-56
gi|23510289 sphingosine-1-phosphate phosphotase 2 [Homo sapiens]       40   0.002
gi|55770876 notch4 preproprotein [Homo sapiens]                        31   1.9  
gi|150456451 hypothetical protein LOC54914 [Homo sapiens]              30   4.3  
gi|13540569 sphingosine-1-phosphate phosphatase 1 [Homo sapiens]       29   5.6  

>gi|10863975 islet-specific glucose-6-phosphatase-related protein
           isoform 1 [Homo sapiens]
          Length = 355

 Score =  746 bits (1927), Expect = 0.0
 Identities = 355/355 (100%), Positives = 355/355 (100%)

Query: 1   MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60
           MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
Sbjct: 1   MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60

Query: 61  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120
           AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS
Sbjct: 61  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120

Query: 121 CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI 180
           CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI
Sbjct: 121 CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI 180

Query: 181 LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK 240
           LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK
Sbjct: 181 LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK 240

Query: 241 KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS 300
           KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS
Sbjct: 241 KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS 300

Query: 301 LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ 355
           LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
Sbjct: 301 LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ 355


>gi|4557599 glucose-6-phosphatase, catalytic subunit [Homo sapiens]
          Length = 357

 Score =  373 bits (958), Expect = e-103
 Identities = 179/355 (50%), Positives = 237/355 (66%), Gaps = 4/355 (1%)

Query: 1   MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60
           M+ LH  G+    +LQ +Y+    +   +S + D RN F++ FP+ F   + VG K++WV
Sbjct: 5   MNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIKLLWV 64

Query: 61  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120
           AVIGDWLNL+FKWILFG RPYWWV +T  Y N S P ++QFP TCETGPGSPSGHAMG +
Sbjct: 65  AVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAMGTA 124

Query: 121 CVWYVMVTAALSHTVCGMDKFSITLH-RLTWSFLWSVFWLIQISVCISRVFIATHFPHQV 179
            V+YVMVT+ LS       K   T   R     LW  FW +Q++VC+SR+++A HFPHQV
Sbjct: 125 GVYYVMVTSTLS---IFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQV 181

Query: 180 ILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIA 239
           + GV+ G+ V E F H   I  ASL  Y     FLF FA+GFYLLL+ L +DLLW++  A
Sbjct: 182 VAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEKA 241

Query: 240 KKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALT 299
           ++WC  P+W+HIDTTPFA L++NLG LFGLG A+NS M+  SC+G  +  L FRL   + 
Sbjct: 242 QRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIVA 301

Query: 300 SLTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKS 354
           SL +L ++  L+ P+  E +FYVLSFCKSA +PL  V+ IPY +  ++ Q  KKS
Sbjct: 302 SLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKS 356


>gi|126273546 islet-specific glucose-6-phosphatase-related protein
           isoform 2 [Homo sapiens]
          Length = 154

 Score =  324 bits (831), Expect = 6e-89
 Identities = 147/147 (100%), Positives = 147/147 (100%)

Query: 1   MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60
           MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
Sbjct: 1   MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60

Query: 61  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120
           AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS
Sbjct: 61  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120

Query: 121 CVWYVMVTAALSHTVCGMDKFSITLHR 147
           CVWYVMVTAALSHTVCGMDKFSITLHR
Sbjct: 121 CVWYVMVTAALSHTVCGMDKFSITLHR 147


>gi|24308434 glucose-6-phosphatase catalytic subunit 3 [Homo
           sapiens]
          Length = 346

 Score =  215 bits (547), Expect = 6e-56
 Identities = 126/350 (36%), Positives = 188/350 (53%), Gaps = 27/350 (7%)

Query: 8   GVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWVAVIGDWL 67
           G++I + LQ           +++ +GDP+ +F  YFP  +  ++ VG  ++W+++I +WL
Sbjct: 8   GIVIAEALQNQLAWLENVWLWITFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWL 67

Query: 68  NLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGASCVWYVMV 127
           NLIFKW LFG RP+WWV E+  Y + +   + QFP++CETGPGSPSGH M      + ++
Sbjct: 68  NLIFKWFLFGDRPFWWVHESGYY-SQAPAQVHQFPSSCETGPGSPSGHCMITGAALWPIM 126

Query: 128 TAALSHTVCGMDKFSITLHRLTW-----SFLWSVFWLIQISVCISRVFIATHFPHQVILG 182
           TA  S           T  R  W     S  +  F L   +V +SR+FI  HFPHQV+ G
Sbjct: 127 TALSSQVA--------TRARSRWVRVMPSLAYCTFLL---AVGLSRIFILAHFPHQVLAG 175

Query: 183 VIGGMLVAEAFEHTPGI-QTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAKK 241
           +I G ++   +  TP +     L  Y  T L L L     Y  L  L +DL WS+ +A K
Sbjct: 176 LITGAVL--GWLMTPRVPMERELSFYGLTALALMLGTSLIYWTLFTLGLDLSWSISLAFK 233

Query: 242 WCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRG--GNNYTLSFRLLCALT 299
           WC  P+WIH+D+ PFA L R+ G   GLG A++S  +    R   GN      ++ C + 
Sbjct: 234 WCERPEWIHVDSRPFASLSRDSGAALGLGIALHSPCYAQVRRAQLGNGQ----KIACLVL 289

Query: 300 SLTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQ 349
           ++ +L    +L  P  +  LFY+ +F K    P  V+A +P++VHM   Q
Sbjct: 290 AMGLLGPLDWLGHPP-QISLFYIFNFLKYTLWPCLVLALVPWAVHMFSAQ 338


>gi|23510289 sphingosine-1-phosphate phosphotase 2 [Homo sapiens]
          Length = 399

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 38/165 (23%), Positives = 73/165 (44%), Gaps = 33/165 (20%)

Query: 36  RNIFFIYFPLCFQFNQTVGTKMIWVAV-------IGDWLN--LIFKWILFGHRPYWWVQE 86
           +N F+ Y    FQF+  +G ++ ++         I  +L+  LI  W+L  +      ++
Sbjct: 82  KNYFYYYL---FQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQV-AKD 137

Query: 87  TQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLH 146
              +P  SSP + +         G PS HAM A+ + + ++ +              T+ 
Sbjct: 138 VLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLIS--------------TMD 183

Query: 147 RLTWSFLWSVFWLIQIS--VCISRVFIATHFPHQVILGVIGGMLV 189
           R  + F+  +   +  S  VC+SR++   H     +L V+GG+L+
Sbjct: 184 RYQYPFVLGLVMAVVFSTLVCLSRLYTGMH----TVLDVLGGVLI 224


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 30.8 bits (68), Expect = 1.9
 Identities = 19/47 (40%), Positives = 21/47 (44%), Gaps = 4/47 (8%)

Query: 68   NLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSG 114
            N  +   L GH   W   E +I P HS PC      TCE   GSP G
Sbjct: 1028 NAFYCQCLPGHTGQWC--EVEIDPCHSQPCFH--GGTCEATAGSPLG 1070


>gi|150456451 hypothetical protein LOC54914 [Homo sapiens]
          Length = 1801

 Score = 29.6 bits (65), Expect = 4.3
 Identities = 22/82 (26%), Positives = 40/82 (48%), Gaps = 6/82 (7%)

Query: 276 EMFLLSCRGGNNYTLSFRLLCALTSL--TILQLYHFLQIPTHEEHLFYVLSFCKSASIPL 333
           EM    C   ++  LS++L+C +TS+  TI   +  L++ T        L+  +S  +P+
Sbjct: 386 EMIQQECYRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESL-LPI 444

Query: 334 TVVAFIP---YSVHMLMKQSGK 352
           T V   P      H+L++  G+
Sbjct: 445 TAVIPAPAFLLLAHLLVEDKGQ 466


>gi|13540569 sphingosine-1-phosphate phosphatase 1 [Homo sapiens]
          Length = 441

 Score = 29.3 bits (64), Expect = 5.6
 Identities = 39/203 (19%), Positives = 76/203 (37%), Gaps = 39/203 (19%)

Query: 39  FFIYFPL-CFQFNQTVGTKM--IWVAV--IGDWLNLIFKWILFGHRPYWWVQETQIYPNH 93
           + ++FP   +  +  VG ++  IWV V  +G     I +W                 P  
Sbjct: 144 YILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRW-----------------PRP 186

Query: 94  SSPCLEQFPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLHRLTWSFL 153
           +SP + +      +    PS HAM  + +   MV             +    + L +  +
Sbjct: 187 ASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLT----------YGRWQYPLIYGLI 236

Query: 154 WSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLF 213
               W     VC+SR+++  H    +I G +  +L+   F     +    +  + +T+ +
Sbjct: 237 LIPCWCSL--VCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDL----IDNFNQTHKY 290

Query: 214 LFLFAVGFYLLLRVLNIDL-LWS 235
                +G +L L + +  L  WS
Sbjct: 291 APFIIIGLHLALGIFSFTLDTWS 313


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.330    0.142    0.480 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,015,709
Number of Sequences: 37866
Number of extensions: 611390
Number of successful extensions: 1641
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1631
Number of HSP's gapped (non-prelim): 9
length of query: 355
length of database: 18,247,518
effective HSP length: 103
effective length of query: 252
effective length of database: 14,347,320
effective search space: 3615524640
effective search space used: 3615524640
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.