Search of human proteins with 10863889

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10863889 squamous cell carcinoma antigen recognized by T
cells 1 [Homo sapiens]
         (800 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10863889 squamous cell carcinoma antigen recognized by T cell...  1566   0.0  
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    64   4e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    64   4e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    64   4e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    64   4e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       64   4e-10
gi|148746195 trichohyalin [Homo sapiens]                               64   6e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        62   3e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        62   3e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         62   3e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         62   3e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         62   3e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         62   3e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         62   3e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         62   3e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    60   1e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    59   1e-08
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    58   3e-08
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    58   3e-08
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  57   5e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    57   7e-08
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        57   7e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    55   3e-07
gi|59806361 hypothetical protein LOC387104 [Homo sapiens]              55   3e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           55   3e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           55   3e-07
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           55   3e-07
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    54   4e-07
gi|31982906 cingulin-like 1 [Homo sapiens]                             54   4e-07
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            52   3e-06

>gi|10863889 squamous cell carcinoma antigen recognized by T cells 1
           [Homo sapiens]
          Length = 800

 Score = 1566 bits (4055), Expect = 0.0
 Identities = 800/800 (100%), Positives = 800/800 (100%)

Query: 1   MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERG 60
           MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERG
Sbjct: 1   MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERG 60

Query: 61  GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
           GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI
Sbjct: 61  GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120

Query: 121 EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLL 180
           EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLL
Sbjct: 121 EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLL 180

Query: 181 NQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEE 240
           NQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEE
Sbjct: 181 NQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEE 240

Query: 241 FGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERA 300
           FGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERA
Sbjct: 241 FGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERA 300

Query: 301 EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGL 360
           EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGL
Sbjct: 301 EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGL 360

Query: 361 RERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRA 420
           RERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRA
Sbjct: 361 RERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRA 420

Query: 421 DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGG 480
           DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGG
Sbjct: 421 DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGG 480

Query: 481 APPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWE 540
           APPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWE
Sbjct: 481 APPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWE 540

Query: 541 EDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG 600
           EDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG
Sbjct: 541 EDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG 600

Query: 601 EENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVAR 660
           EENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVAR
Sbjct: 601 EENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVAR 660

Query: 661 VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKL 720
           VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKL
Sbjct: 661 VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKL 720

Query: 721 TPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK 780
           TPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK
Sbjct: 721 TPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK 780

Query: 781 TPYIVLSGSGKSMNANTITK 800
           TPYIVLSGSGKSMNANTITK
Sbjct: 781 TPYIVLSGSGKSMNANTITK 800


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 172/786 (21%), Positives = 309/786 (39%), Gaps = 107/786 (13%)

Query: 54   KRSRERGGERGSGRRGAEAEA-RSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSS 112
            +R+     E+     G E EA ++       S A   E R KRE+     + A   +T S
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 113  GDAS--------SLSIEE-TNKL----RAKLGL----KPLE------------VNAIKKE 143
             +A         + ++EE T +L    RAK  L    + LE            +   K+E
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 144  AGTKEEPVTADVINPMAL-----RQREELREKLAAAKEK-----RLLNQKLGKIKTLGED 193
               K++ + A V    +      R R EL +K+   + +      +LN+  GK   L +D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 194  ----DPWLDDTAAWI-ERSRQL----QKEKDLAEKRAKLLEEMDQEFGVSTLVE------ 238
                   L DT   + E +RQ      K + L E+R  L +++D+E      +E      
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 239  -----------EEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTL-KDKGVLQEEE 286
                       ++F    + L   +      +E+    + E       L K K  LQ+E 
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 287  DVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERP 346
            D LV V+L ++ +   N+E +++K D L   E       A ++ R+     ++E +    
Sbjct: 1430 DDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LS 1487

Query: 347  HSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRV 406
             +  LE+   A    ER  + ++A++     S   VG  +     +   + T  +  +  
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDT 466
             +  + E +    A   L +  Q   G F   L+ R  +     EE++  + + L   +T
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYET 1603

Query: 467  RVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLE-KGR-----RLRQLQ------- 513
             +E     DE +  A    + + LE D  +LELQ     KGR     +LR+LQ       
Sbjct: 1604 ELE-----DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658

Query: 514  -QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLA 572
             +L+  R S +++    K+ E + +  E D    ++         +      E     LA
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 573  GNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEP 632
             +   +  L D +R  E       E   EE      ++    K  Q     S  +  E  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 633  IVNRGLAAALLL-CQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRRE-- 689
               +  +A   L  QNK L     +    VK+  K   S +  +E K+A  ++   +E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK---STIAALEAKIAQLEEQVEQEAR 1835

Query: 690  EYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMK-TERRMK 748
            E +  T+  K+KD    ++ ++  DE  RK+   E +++ +     KG+ ++K  +R+++
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDE--RKMA--EQYKEQAE----KGNARVKQLKRQLE 1887

Query: 749  KLDEEA 754
            + +EE+
Sbjct: 1888 EAEEES 1893



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 115/531 (21%), Positives = 211/531 (39%), Gaps = 93/531 (17%)

Query: 96   EKRDDGYEAAASSKTSSGDASSLS--IEETNKLRAKLGLKPLEVNA-IKKEAGTKEEPVT 152
            E+ D G +  A  K  +     L   +EE    R KL L+ +   A IKK    ++E + 
Sbjct: 933  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK---LEDEILV 989

Query: 153  ADVINPMALRQREELREKLA------AAKEKRLLNQKLGKIKTLGEDD-PWLDDTAAWIE 205
             D  N    ++R+ L E+++      A +E++  N  L K+K   E     L+      E
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESMISELEVRLKKEE 1047

Query: 206  RSRQ-LQKEK-------------------DLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            +SRQ L+K K                    +AE + +L ++ ++       +++E  Q+ 
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1107

Query: 246  QDLYSARDLQG--------LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDK 297
              L   R+L+G        L  E A  +  E +   L  + + +  E ED L +     +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167

Query: 298  ERA--EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELE---------GERP 346
             RA  E+ V + KK  D    + +  V ++ +QK    + +  E+LE          +  
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNK 1226

Query: 347  HSFRLEQGGTADGLR-----ERELEEIRAKLRLQAQSLSTV---GPRLASEYLTPEEMVT 398
             +   E    A  LR     ++E+E  + KL  Q Q L +    G R  +E L  +    
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKL 1285

Query: 399  FKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVS----EVEEEK 454
              + +     + + E + +  A D+  L  Q QD     +   R +  VS    ++EEE+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345

Query: 455  EPVPQPLPSDDTRVENMD---------ISDEEEGGAPPPGSPQVLEEDEAELELQ----- 500
              +   L  +    +N++         +SD ++       + + LEE +   + +     
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405

Query: 501  ----------KQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEE 541
                       +LEK +  R  Q+L  L    +   ++V  LE +QR +++
Sbjct: 1406 QQYEEKAAAYDKLEKTKN-RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 172/786 (21%), Positives = 309/786 (39%), Gaps = 107/786 (13%)

Query: 54   KRSRERGGERGSGRRGAEAEA-RSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSS 112
            +R+     E+     G E EA ++       S A   E R KRE+     + A   +T S
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 113  GDAS--------SLSIEE-TNKL----RAKLGL----KPLE------------VNAIKKE 143
             +A         + ++EE T +L    RAK  L    + LE            +   K+E
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 144  AGTKEEPVTADVINPMAL-----RQREELREKLAAAKEK-----RLLNQKLGKIKTLGED 193
               K++ + A V    +      R R EL +K+   + +      +LN+  GK   L +D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 194  ----DPWLDDTAAWI-ERSRQL----QKEKDLAEKRAKLLEEMDQEFGVSTLVE------ 238
                   L DT   + E +RQ      K + L E+R  L +++D+E      +E      
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 239  -----------EEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTL-KDKGVLQEEE 286
                       ++F    + L   +      +E+    + E       L K K  LQ+E 
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 287  DVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERP 346
            D LV V+L ++ +   N+E +++K D L   E       A ++ R+     ++E +    
Sbjct: 1437 DDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LS 1494

Query: 347  HSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRV 406
             +  LE+   A    ER  + ++A++     S   VG  +     +   + T  +  +  
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDT 466
             +  + E +    A   L +  Q   G F   L+ R  +     EE++  + + L   +T
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYET 1610

Query: 467  RVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLE-KGR-----RLRQLQ------- 513
             +E     DE +  A    + + LE D  +LELQ     KGR     +LR+LQ       
Sbjct: 1611 ELE-----DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 514  -QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLA 572
             +L+  R S +++    K+ E + +  E D    ++         +      E     LA
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 573  GNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEP 632
             +   +  L D +R  E       E   EE      ++    K  Q     S  +  E  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 633  IVNRGLAAALLL-CQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRRE-- 689
               +  +A   L  QNK L     +    VK+  K   S +  +E K+A  ++   +E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK---STIAALEAKIAQLEEQVEQEAR 1842

Query: 690  EYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMK-TERRMK 748
            E +  T+  K+KD    ++ ++  DE  RK+   E +++ +     KG+ ++K  +R+++
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDE--RKMA--EQYKEQAE----KGNARVKQLKRQLE 1894

Query: 749  KLDEEA 754
            + +EE+
Sbjct: 1895 EAEEES 1900



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 115/531 (21%), Positives = 211/531 (39%), Gaps = 93/531 (17%)

Query: 96   EKRDDGYEAAASSKTSSGDASSLS--IEETNKLRAKLGLKPLEVNA-IKKEAGTKEEPVT 152
            E+ D G +  A  K  +     L   +EE    R KL L+ +   A IKK    ++E + 
Sbjct: 940  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK---LEDEILV 996

Query: 153  ADVINPMALRQREELREKLA------AAKEKRLLNQKLGKIKTLGEDD-PWLDDTAAWIE 205
             D  N    ++R+ L E+++      A +E++  N  L K+K   E     L+      E
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESMISELEVRLKKEE 1054

Query: 206  RSRQ-LQKEK-------------------DLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            +SRQ L+K K                    +AE + +L ++ ++       +++E  Q+ 
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1114

Query: 246  QDLYSARDLQG--------LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDK 297
              L   R+L+G        L  E A  +  E +   L  + + +  E ED L +     +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174

Query: 298  ERA--EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELE---------GERP 346
             RA  E+ V + KK  D    + +  V ++ +QK    + +  E+LE          +  
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNK 1233

Query: 347  HSFRLEQGGTADGLR-----ERELEEIRAKLRLQAQSLSTV---GPRLASEYLTPEEMVT 398
             +   E    A  LR     ++E+E  + KL  Q Q L +    G R  +E L  +    
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKL 1292

Query: 399  FKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVS----EVEEEK 454
              + +     + + E + +  A D+  L  Q QD     +   R +  VS    ++EEE+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352

Query: 455  EPVPQPLPSDDTRVENMD---------ISDEEEGGAPPPGSPQVLEEDEAELELQ----- 500
              +   L  +    +N++         +SD ++       + + LEE +   + +     
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412

Query: 501  ----------KQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEE 541
                       +LEK +  R  Q+L  L    +   ++V  LE +QR +++
Sbjct: 1413 QQYEEKAAAYDKLEKTKN-RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 172/786 (21%), Positives = 309/786 (39%), Gaps = 107/786 (13%)

Query: 54   KRSRERGGERGSGRRGAEAEA-RSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSS 112
            +R+     E+     G E EA ++       S A   E R KRE+     + A   +T S
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 113  GDAS--------SLSIEE-TNKL----RAKLGL----KPLE------------VNAIKKE 143
             +A         + ++EE T +L    RAK  L    + LE            +   K+E
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 144  AGTKEEPVTADVINPMAL-----RQREELREKLAAAKEK-----RLLNQKLGKIKTLGED 193
               K++ + A V    +      R R EL +K+   + +      +LN+  GK   L +D
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 194  ----DPWLDDTAAWI-ERSRQL----QKEKDLAEKRAKLLEEMDQEFGVSTLVE------ 238
                   L DT   + E +RQ      K + L E+R  L +++D+E      +E      
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 239  -----------EEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTL-KDKGVLQEEE 286
                       ++F    + L   +      +E+    + E       L K K  LQ+E 
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 287  DVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERP 346
            D LV V+L ++ +   N+E +++K D L   E       A ++ R+     ++E +    
Sbjct: 1437 DDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LS 1494

Query: 347  HSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRV 406
             +  LE+   A    ER  + ++A++     S   VG  +     +   + T  +  +  
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDT 466
             +  + E +    A   L +  Q   G F   L+ R  +     EE++  + + L   +T
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYET 1610

Query: 467  RVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLE-KGR-----RLRQLQ------- 513
             +E     DE +  A    + + LE D  +LELQ     KGR     +LR+LQ       
Sbjct: 1611 ELE-----DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 514  -QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLA 572
             +L+  R S +++    K+ E + +  E D    ++         +      E     LA
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 573  GNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEP 632
             +   +  L D +R  E       E   EE      ++    K  Q     S  +  E  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 633  IVNRGLAAALLL-CQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRRE-- 689
               +  +A   L  QNK L     +    VK+  K   S +  +E K+A  ++   +E  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK---STIAALEAKIAQLEEQVEQEAR 1842

Query: 690  EYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMK-TERRMK 748
            E +  T+  K+KD    ++ ++  DE  RK+   E +++ +     KG+ ++K  +R+++
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDE--RKMA--EQYKEQAE----KGNARVKQLKRQLE 1894

Query: 749  KLDEEA 754
            + +EE+
Sbjct: 1895 EAEEES 1900



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 115/531 (21%), Positives = 211/531 (39%), Gaps = 93/531 (17%)

Query: 96   EKRDDGYEAAASSKTSSGDASSLS--IEETNKLRAKLGLKPLEVNA-IKKEAGTKEEPVT 152
            E+ D G +  A  K  +     L   +EE    R KL L+ +   A IKK    ++E + 
Sbjct: 940  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK---LEDEILV 996

Query: 153  ADVINPMALRQREELREKLA------AAKEKRLLNQKLGKIKTLGEDD-PWLDDTAAWIE 205
             D  N    ++R+ L E+++      A +E++  N  L K+K   E     L+      E
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESMISELEVRLKKEE 1054

Query: 206  RSRQ-LQKEK-------------------DLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            +SRQ L+K K                    +AE + +L ++ ++       +++E  Q+ 
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1114

Query: 246  QDLYSARDLQG--------LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDK 297
              L   R+L+G        L  E A  +  E +   L  + + +  E ED L +     +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174

Query: 298  ERA--EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELE---------GERP 346
             RA  E+ V + KK  D    + +  V ++ +QK    + +  E+LE          +  
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNK 1233

Query: 347  HSFRLEQGGTADGLR-----ERELEEIRAKLRLQAQSLSTV---GPRLASEYLTPEEMVT 398
             +   E    A  LR     ++E+E  + KL  Q Q L +    G R  +E L  +    
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKL 1292

Query: 399  FKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVS----EVEEEK 454
              + +     + + E + +  A D+  L  Q QD     +   R +  VS    ++EEE+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352

Query: 455  EPVPQPLPSDDTRVENMD---------ISDEEEGGAPPPGSPQVLEEDEAELELQ----- 500
              +   L  +    +N++         +SD ++       + + LEE +   + +     
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412

Query: 501  ----------KQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEE 541
                       +LEK +  R  Q+L  L    +   ++V  LE +QR +++
Sbjct: 1413 QQYEEKAAAYDKLEKTKN-RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 172/786 (21%), Positives = 309/786 (39%), Gaps = 107/786 (13%)

Query: 54   KRSRERGGERGSGRRGAEAEA-RSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSS 112
            +R+     E+     G E EA ++       S A   E R KRE+     + A   +T S
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 113  GDAS--------SLSIEE-TNKL----RAKLGL----KPLE------------VNAIKKE 143
             +A         + ++EE T +L    RAK  L    + LE            +   K+E
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 144  AGTKEEPVTADVINPMAL-----RQREELREKLAAAKEK-----RLLNQKLGKIKTLGED 193
               K++ + A V    +      R R EL +K+   + +      +LN+  GK   L +D
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 194  ----DPWLDDTAAWI-ERSRQL----QKEKDLAEKRAKLLEEMDQEFGVSTLVE------ 238
                   L DT   + E +RQ      K + L E+R  L +++D+E      +E      
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 239  -----------EEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTL-KDKGVLQEEE 286
                       ++F    + L   +      +E+    + E       L K K  LQ+E 
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 287  DVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERP 346
            D LV V+L ++ +   N+E +++K D L   E       A ++ R+     ++E +    
Sbjct: 1430 DDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LS 1487

Query: 347  HSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRV 406
             +  LE+   A    ER  + ++A++     S   VG  +     +   + T  +  +  
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDT 466
             +  + E +    A   L +  Q   G F   L+ R  +     EE++  + + L   +T
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYET 1603

Query: 467  RVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLE-KGR-----RLRQLQ------- 513
             +E     DE +  A    + + LE D  +LELQ     KGR     +LR+LQ       
Sbjct: 1604 ELE-----DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658

Query: 514  -QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLA 572
             +L+  R S +++    K+ E + +  E D    ++         +      E     LA
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 573  GNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEP 632
             +   +  L D +R  E       E   EE      ++    K  Q     S  +  E  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 633  IVNRGLAAALLL-CQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRRE-- 689
               +  +A   L  QNK L     +    VK+  K   S +  +E K+A  ++   +E  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK---STIAALEAKIAQLEEQVEQEAR 1835

Query: 690  EYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMK-TERRMK 748
            E +  T+  K+KD    ++ ++  DE  RK+   E +++ +     KG+ ++K  +R+++
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDE--RKMA--EQYKEQAE----KGNARVKQLKRQLE 1887

Query: 749  KLDEEA 754
            + +EE+
Sbjct: 1888 EAEEES 1893



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 115/531 (21%), Positives = 211/531 (39%), Gaps = 93/531 (17%)

Query: 96   EKRDDGYEAAASSKTSSGDASSLS--IEETNKLRAKLGLKPLEVNA-IKKEAGTKEEPVT 152
            E+ D G +  A  K  +     L   +EE    R KL L+ +   A IKK    ++E + 
Sbjct: 933  EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK---LEDEILV 989

Query: 153  ADVINPMALRQREELREKLA------AAKEKRLLNQKLGKIKTLGEDD-PWLDDTAAWIE 205
             D  N    ++R+ L E+++      A +E++  N  L K+K   E     L+      E
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN--LTKLKNKHESMISELEVRLKKEE 1047

Query: 206  RSRQ-LQKEK-------------------DLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            +SRQ L+K K                    +AE + +L ++ ++       +++E  Q+ 
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1107

Query: 246  QDLYSARDLQG--------LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDK 297
              L   R+L+G        L  E A  +  E +   L  + + +  E ED L +     +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167

Query: 298  ERA--EKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELE---------GERP 346
             RA  E+ V + KK  D    + +  V ++ +QK    + +  E+LE          +  
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEM-RQKHAQAVEELTEQLEQFKRAKANLDKNK 1226

Query: 347  HSFRLEQGGTADGLR-----ERELEEIRAKLRLQAQSLSTV---GPRLASEYLTPEEMVT 398
             +   E    A  LR     ++E+E  + KL  Q Q L +    G R  +E L  +    
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHKL 1285

Query: 399  FKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVS----EVEEEK 454
              + +     + + E + +  A D+  L  Q QD     +   R +  VS    ++EEE+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345

Query: 455  EPVPQPLPSDDTRVENMD---------ISDEEEGGAPPPGSPQVLEEDEAELELQ----- 500
              +   L  +    +N++         +SD ++       + + LEE +   + +     
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405

Query: 501  ----------KQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEE 541
                       +LEK +  R  Q+L  L    +   ++V  LE +QR +++
Sbjct: 1406 QQYEEKAAAYDKLEKTKN-RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 109/532 (20%), Positives = 210/532 (39%), Gaps = 73/532 (13%)

Query: 71  EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
           E E +S +  +ER + E +E   K  +++D  +A  + K    D      EE    R  +
Sbjct: 148 EKEEKSESR-QERYEIEETETVTKSYQKNDWRDAEENKKE---DKEKEEEEEEKPKRGSI 203

Query: 131 GLKPLEVNAIKKEAGTKEEPVTADVIN-------PMALRQREELREKL------------ 171
           G   +EV   +K   ++EE V   + N       P    +RE+  +++            
Sbjct: 204 GENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE 263

Query: 172 -AAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQL---QKEKDLAEKRAKLLEEM 227
            A A+  RL  ++  +IK   E D  + D  A IE   +    ++E+  AE+R ++ EE 
Sbjct: 264 RAEAERARLEAEERERIKA--EQDKKIADERARIEAEEKAAAQERERREAEERERMREEE 321

Query: 228 DQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEED 287
            +       ++EE  +  ++    ++ +    E      +E E      + +   +EEE 
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER-QRIKEEEKRAAEERQRARAEEEEK 380

Query: 288 VLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPH 347
             V       E  ++N +L +KK               A Q+ +    K ++++EG+  +
Sbjct: 381 AKV-------EEQKRNKQLEEKKH--------------AMQETKIKGEKVEQKIEGKWVN 419

Query: 348 SFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVK 407
             + ++      + +++ EE   K++ + + L    P    E +  E++   K+ K  VK
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479

Query: 408 KIRKKEK---EVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSD 464
               ++K   EV  +  + +    +  +  F    R  GR  V   E E  P  +     
Sbjct: 480 SFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS---RPGGRASVDTKEAEGAPQVEA---- 532

Query: 465 DTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEK 524
             R+E +     E             E +E E   QKQ E    L +L++ ++ R    +
Sbjct: 533 GKRLEELRRRRGET------------ESEEFEKLKQKQQEAALELEELKKKREERRKVLE 580

Query: 525 VVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNRE 576
             E  +K E   R   E+E+  R    +    +E      ++P  GL+ +++
Sbjct: 581 EEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 114/544 (20%), Positives = 219/544 (40%), Gaps = 82/544 (15%)

Query: 73  EARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGL 132
           E R     ++R +      R+  ++ DD  E AA  +        L  ++  +   ++  
Sbjct: 5   ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV-T 63

Query: 133 KPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRL--LNQKLGKIKTL 190
             +EVNA  + +   EE  T      +         E+LA  +E+R   L + L + K  
Sbjct: 64  DQVEVNA--QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-- 119

Query: 191 GEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYS 250
            E DP + D +  +  SR++Q   D AE                T  +EE  + RQ+ Y 
Sbjct: 120 -EFDPTITDASLSLP-SRRMQN--DTAENE--------------TTEKEEKSESRQERYE 161

Query: 251 ARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKK 310
             + + +T  +  + +R+ E      K+K   +EEE+       + + + E  VE +  +
Sbjct: 162 IEETETVTKSYQKNDWRDAEENKKEDKEK---EEEEEEKPKRGSIGENQVEVMVEEKTTE 218

Query: 311 PDYLPYAEDESVDDLAQQKPRSILSKYDEELE---GERPHSFRLEQGGTADGLRERELEE 367
                  E+  V  L   +  S   K +EE E    E  H  ++E+        ER   E
Sbjct: 219 SQ-----EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLE 273

Query: 368 IRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLG 427
              + R++A+    +    A   +  EE    ++ +RR  + R++ +E   RA       
Sbjct: 274 AEERERIKAEQDKKIADERAR--IEAEEKAAAQERERREAEERERMREEEKRA------- 324

Query: 428 DQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRV--ENMDISDEEEGGAPPPG 485
                           R+R+ E E+      Q +  ++ R   E   I +EE+  A    
Sbjct: 325 -------------AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371

Query: 486 SPQVLEEDEAELELQKQLEKGRRLRQLQQ----LQQLRDSGEKVVEIVKKLESRQRGWEE 541
             +  EE++A++E QK      R +QL++    +Q+ +  GEKV +   K+E +    ++
Sbjct: 372 RARAEEEEKAKVEEQK------RNKQLEEKKHAMQETKIKGEKVEQ---KIEGKWVNEKK 422

Query: 542 DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREE-QEELMDFERDEERSANGGSESDG 600
            ++ + + A++        +  GE     +   RE+ QE+   F+++E +      + + 
Sbjct: 423 AQEDKLQTAVL--------KKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474

Query: 601 EENI 604
           +E +
Sbjct: 475 KEEV 478



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 97/490 (19%), Positives = 198/490 (40%), Gaps = 92/490 (18%)

Query: 51  ERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKT 110
           ER +   E+  +    R   EAE +++   RER +AE  ER  + EKR      AA  + 
Sbjct: 276 ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKR------AAEERQ 329

Query: 111 SSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREK 170
              +    + EE  +++ +      E  A ++    KEE            ++  E R++
Sbjct: 330 RIKEEEKRAAEERQRIKEE------EKRAAEERQRIKEEE-----------KRAAEERQR 372

Query: 171 LAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQE 230
             A +E++   ++  + K L E    + +T    E+  Q  + K + EK+A       QE
Sbjct: 373 ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA-------QE 425

Query: 231 FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLV 290
             + T V ++ G+ +     A+  +   ++    +F++ E     +KD+ + +++E    
Sbjct: 426 DKLQTAVLKKQGEEKGTKVQAKREK---LQEDKPTFKKEE-----IKDEKIKKDKEPKEE 477

Query: 291 NVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEE-----LEGER 345
             + +D+++     E++ +  +++ +    + +  ++   R+ +   + E       G+R
Sbjct: 478 VKSFMDRKKG--FTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535

Query: 346 PHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRR 405
               R  +G T       E E+++ K +  A  L  +  +        EE    +K +  
Sbjct: 536 LEELRRRRGET----ESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 591

Query: 406 VKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDD 465
            +K+R++E++                      RL+    RR +E  E+++ +P+   SDD
Sbjct: 592 DRKLREEEEK---------------------RRLKEEIERRRAEAAEKRQKMPEDGLSDD 630

Query: 466 TRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKV 525
            +               P GS   +EE  AE  L K ++K   ++   Q           
Sbjct: 631 KKPFKC---------FTPKGSSLKIEE-RAEF-LNKSVQKSSGVKSTHQ----------- 668

Query: 526 VEIVKKLESR 535
             IV K++SR
Sbjct: 669 AAIVSKIDSR 678



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 94/459 (20%), Positives = 186/459 (40%), Gaps = 60/459 (13%)

Query: 361 RERELE-EIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKE---- 415
           R REL  + R ++RL+A+       R+A +    +E    ++ +RR ++ R ++K+    
Sbjct: 6   RRRELRRQKREEMRLEAE-------RIAYQRNDDDEEEAARERRRRARQERLRQKQEEES 58

Query: 416 -------VVVRADDLLPLGD------QTQ-DGD----FGSRLRGRGRRRVSEVEEEKEPV 457
                  V V A + +P  +       TQ +GD    F  RL  R  RR   ++E  E  
Sbjct: 59  LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ 118

Query: 458 PQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQK--QLEKGRRLRQLQQL 515
            +     D  + +  +S             +  E++E     Q+  ++E+   + +  Q 
Sbjct: 119 KE----FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174

Query: 516 QQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATS---EFCRTLGEIPTYGLA 572
              RD+ E       K E +++  EE+E P+R G+I  N      E   T  +  T  ++
Sbjct: 175 NDWRDAEEN------KKEDKEKEEEEEEKPKR-GSIGENQVEVMVEEKTTESQEETVVMS 227

Query: 573 ---GNREEQEELMDFERDE---ERSANGGSESDGEENIGWSTVNLDEEKQQQDFSASSTT 626
              G    +E   + ER++   E S +   E + +E        L+ E++++  +     
Sbjct: 228 LKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKK 287

Query: 627 ILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYS 686
           I DE   +     AA    Q +   E   ++  R +    +        E+K A +++  
Sbjct: 288 IADERARIEAEEKAA---AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344

Query: 687 RREEYRGFTQDFK-----EKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKM 741
            +EE +   ++ +     EK   +   +    +E   K+  ++  +QL  + H     K+
Sbjct: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404

Query: 742 KTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQK 780
           K E+  +K++ + + +K +  D     V   Q ++K  K
Sbjct: 405 KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 55/333 (16%), Positives = 121/333 (36%), Gaps = 10/333 (3%)

Query: 31  RHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSE 90
           R R   + + R         E R+R +E        R+  + E + +   R+R + E  E
Sbjct: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEE--E 363

Query: 91  RRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEP 150
           +R   E++    E    +K       +  +EE      +  +K  +V    +     E+ 
Sbjct: 364 KRAAEERQRARAEEEEKAKVEE-QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422

Query: 151 VTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQL 210
              D +    L+++ E +     AK ++L   K    K   +D+    D     E    +
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM 482

Query: 211 QKEKDLAEKRAKLLEEMDQEF-GVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREG 269
            ++K   E +++  E M  +            G+   D   A     +     ++  R  
Sbjct: 483 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 542

Query: 270 ETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQK 329
                + + + + Q++++  + +  + K+R E+   L +++        D  + +  +++
Sbjct: 543 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKR 602

Query: 330 PRSILSKYDEELEGERPHSFRLEQGGTADGLRE 362
                 +  EE+E  R  +    Q    DGL +
Sbjct: 603 ------RLKEEIERRRAEAAEKRQKMPEDGLSD 629


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 152/722 (21%), Positives = 275/722 (38%), Gaps = 129/722 (17%)

Query: 51   ERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSK- 109
            +R KR       R    +  E E R     R R Q E  E+R+KRE+ ++  E     + 
Sbjct: 618  QRLKREEPEEERRQQLLKSEEQEERRQQQLR-REQQERREQRLKREEEEERLEQRLKREH 676

Query: 110  TSSGDASSLSIEETNKLRAKLGLK-PLEVNAIKKEAGTKEEPVTADVINPMALRQREELR 168
                    L+ EE  + R ++  + P     ++ EA  ++  V +        R+R+E  
Sbjct: 677  EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736

Query: 169  EKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAW-----IERSRQ-LQKEKDLAEKRAK 222
            EK    + +    ++    +   E++   D T  W      ER RQ L     L E+R +
Sbjct: 737  EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER 796

Query: 223  LL---EEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDK 279
             L   E   +E       EE+  +RRQ     ++LQ          F E E  +   +  
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ----------FLEEEEQLQRRERA 846

Query: 280  GVLQEEEDVLVNVNLVDKERAEKNVELR-----------KKKPDYLPYAEDESVDDLAQQ 328
              LQEEED L      D+ER     + R           +K+  +  YA+    + L  +
Sbjct: 847  QQLQEEEDGLQE----DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL--R 900

Query: 329  KPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLAS 388
            K + +L + +EEL+ E     R          R+ +  + R + +LQ +           
Sbjct: 901  KEQQLLQEEEEELQREEREKRR----------RQEQERQYREEEQLQQEE---------- 940

Query: 389  EYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVS 448
                 E+++  ++ KRR     ++E+E   R D  L   ++   G+   + R + R +  
Sbjct: 941  -----EQLLREEREKRR-----RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 449  EVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRR 508
              EEE                   +  EEE         Q+L E+  +   Q+   + R+
Sbjct: 991  REEEE-------------------LQQEEE---------QLLREEREKRRRQEWERQYRK 1022

Query: 509  LRQLQQLQQ--LRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEI 566
              +LQQ ++  LR+  EK     ++L+ R+R + E+E+ +++   +     E  R     
Sbjct: 1023 KDELQQEEEQLLREEREK-----RRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077

Query: 567  PTYGLAGN-REEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEE----------- 614
              Y      ++E+E+L+  E ++ R      +   EE +      L  E           
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137

Query: 615  ---KQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSA 671
               +++++       +L EEP   R         + + L +   Q +   +   +     
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197

Query: 672  VYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPD----VKIEYVDETGRKLTPKEAFR 727
             Y  E+++    +  R++ YR   Q    K  ++P+    V+   V   GR+    E FR
Sbjct: 1198 QYREEEEL---QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE---NEQFR 1251

Query: 728  QL 729
            QL
Sbjct: 1252 QL 1253



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 115/608 (18%), Positives = 246/608 (40%), Gaps = 96/608 (15%)

Query: 27  EQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQA 86
           +Q  R +E ++H+ +         E+ +R +    E+   R   + E  +  H +ER + 
Sbjct: 423 QQLRREQEEERHEQKH--------EQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474

Query: 87  EPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGT 146
           +  +R  + E+R+   +     +    +     +    + R +  LK  E     ++   
Sbjct: 475 Q-LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 147 KEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIER 206
            E+ +          R++EE RE+L   +E++ L Q+                      R
Sbjct: 534 SEQQLR---------REQEERREQLLKREEEKRLEQE---------------------RR 563

Query: 207 SRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSF 266
            ++L++E++  E+R +LL+            EEE  Q+R        L+       ++  
Sbjct: 564 EQRLKREQE--ERRDQLLKR-----------EEERRQQRLKREQEERLEQRLKREEVERL 610

Query: 267 REGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLA 326
            + E     LK +   +E    L+     +++   +  +LR++                 
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLK---SEEQEERRQQQLRRE----------------- 650

Query: 327 QQKPRSILSKYDEELEG-----ERPHSFRLEQGGTADGLRERELEEIRAKL-RLQAQSLS 380
           QQ+ R    K +EE E      +R H     +   A+  +E+  E I++++ + Q Q  S
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 381 TVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQD--GDF--- 435
               R +  Y  P +    ++ + + +K R++E E+  + ++      Q ++   DF   
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770

Query: 436 --GSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEED 493
                   RGR+R+S     +E   + L +++ +        EEE         +  E++
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE 830

Query: 494 EAELELQKQLEKGRRLRQLQQLQQ-LRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIV 552
              LE ++QL++  R +QLQ+ +  L++  E+     ++ + + R W+ +E+ +R+   +
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR-WQLEEERKRRRHTL 889

Query: 553 F--NATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVN 610
           +   A  E  R   ++        +EE+EEL   ER++ R      +   EE +      
Sbjct: 890 YAKPALQEQLRKEQQL-------LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942

Query: 611 LDEEKQQQ 618
           L  E++++
Sbjct: 943 LLREEREK 950



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 110/536 (20%), Positives = 224/536 (41%), Gaps = 55/536 (10%)

Query: 27   EQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQA 86
            E+  R R+ ++ ++R         + +++  +  GE    RR  E E +     RE  + 
Sbjct: 947  EREKRRRQERERQYRKDK------KLQQKEEQLLGEEPEKRRRQEREKKY----REEEEL 996

Query: 87   EPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIK----K 142
            +  E ++ RE+R+         +    D   L  EE   LR +   + L+    +    +
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKKD--ELQQEEEQLLREEREKRRLQERERQYREEE 1054

Query: 143  EAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAA 202
            E   +EE +  +       R+R+EL  +    KE+ L  ++    + L  ++P   +   
Sbjct: 1055 ELQQEEEQLLGE---ERETRRRQELERQYR--KEEELQQEE----EQLLREEP---EKRR 1102

Query: 203  WIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLV----EEEFGQRRQDLYSARDLQGLT 258
              ER RQ ++E++L ++  +LL E  ++     L     EEE  Q+ ++     + +   
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162

Query: 259  VEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAE 318
             +     +RE E   L  +++ +L+EE++         + R E+ ++ +K+K  Y    E
Sbjct: 1163 RQELERQYREEEE--LQQEEEQLLREEQEKR-RQERERQYREEEELQRQKRKQRYRD--E 1217

Query: 319  DESVDDLAQQKPRSILSKYDEEL--EGERPHSFR-LEQGGTADGLRERELEEIRAKLRLQ 375
            D+  D   Q +P    +  D ++  +G     FR LE     D   +++L+ +  + + +
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277

Query: 376  AQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDF 435
             +       +    +   EE +  ++ K   ++ RK ++E  +       L ++ ++   
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL-------LREEREE--- 1327

Query: 436  GSRLRGRGRRRVSEVEE---EKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEE 492
              R R    R+  E E+   E+E  P      D +    ++  +E+G        Q L  
Sbjct: 1328 -KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE-EEQRLRR 1385

Query: 493  DEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
             E E +  K+ ++ R   + QQL+Q RD   +  E     + R R + E+E   R+
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 118/577 (20%), Positives = 231/577 (40%), Gaps = 71/577 (12%)

Query: 49  GGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASS 108
           G  RR++ +E+  E   G   +E + R     R+R   E   +R + ++R++        
Sbjct: 134 GQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL 193

Query: 109 KTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELR 168
           ++  G  +    +E    R +L    LE+    +E   ++     D +      +    R
Sbjct: 194 QSCKGHETEEFPDEEQLRRREL----LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249

Query: 169 EKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAW-IERSRQLQKEKDLAEKRAKLLEEM 227
           E +   +E++L  ++  + + L E++  L       + R RQ ++++    +R + L   
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 228 DQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEED 287
            +E       E    Q R++    R  Q L  E   +  RE +           L+ E++
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQ--EERREQQ-----------LRREQE 356

Query: 288 VLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPH 347
                  + +E+ E+  E + ++   L     E      QQ  R    + +++L   R  
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQL---RREQQLRREQQLRREQQLRREQQL--RREQ 411

Query: 348 SFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASE---YLTPEEMVTFKKTKR 404
             R EQ    +    RE EE R + + + +       R   E   +L  EE     + +R
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471

Query: 405 RVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSD 464
           R +++++ ++E   R +  L L ++ +        R +  RR  ++  E+E         
Sbjct: 472 RKQQLKRDQEE--ERRERWLKLEEEER--------REQQERREQQLRREQE--------- 512

Query: 465 DTRVENMDISDEEEGGAPPPGSPQVL--EEDEAELELQKQLEKGRRLRQLQQLQQL-RDS 521
           + R + +   +EEE       S Q L  E++E   +L K+ E+ +RL Q ++ Q+L R+ 
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR-EEEKRLEQERREQRLKREQ 571

Query: 522 GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEEL 581
            E+  +++K+ E R++   + E  ER    +                      REE E L
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRL---------------------KREEVERL 610

Query: 582 MDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQ 618
              ER E+R      E +  + +   +   +E +QQQ
Sbjct: 611 EQEERREQRLKREEPEEERRQQL-LKSEEQEERRQQQ 646



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 101/450 (22%), Positives = 185/450 (41%), Gaps = 98/450 (21%)

Query: 194 DPWLDDTAAWIERSRQLQKEKDLAE-----KRAKLLEEMDQEFGVSTLVEEEFGQRRQDL 248
           D  L++      R ++ ++E++LAE     ++ + LE+ D++       +EE  ++RQ+ 
Sbjct: 126 DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRR-----DEELWRQRQEW 180

Query: 249 YSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRK 308
               + +    E  + S +  ET      D+  L+  E     + L  K R EK  + R+
Sbjct: 181 QEREERRA--EEEQLQSCKGHETE--EFPDEEQLRRRE----LLELRRKGREEKQQQ-RR 231

Query: 309 KKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEI 368
           ++ D +   E+E       +K  ++L K +E+L+ E P              R+REL+E 
Sbjct: 232 ERQDRVFQEEEEK----EWRKRETVLRKEEEKLQEEEPQ-------------RQRELQEE 274

Query: 369 RAKLR-LQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLG 427
             +LR L+ Q L              +E    ++  RR +++R+K++E   R +      
Sbjct: 275 EEQLRKLERQELRR----------ERQEEEQQQQRLRREQQLRRKQEEE--RREQ----- 317

Query: 428 DQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            Q +  +   R   +  RR  ++  E+E         + R + +    EEE         
Sbjct: 318 -QEERREQQERREQQEERREQQLRREQE---------ERREQQLRREQEEERREQQLRRE 367

Query: 488 QVLEEDEAELELQKQLEKGRRLRQLQQL---------QQLRDSGEKVVEIVKKLESRQRG 538
           Q  E  E +L  ++QL + ++LR+ QQL         QQLR   +   E   + E + R 
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427

Query: 539 WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSE- 597
            +E+E  E+K         E  R    +        + EQEE  D+ + EE +     E 
Sbjct: 428 EQEEERHEQK--------HEQERREQRL--------KREQEERRDWLKREEETERHEQER 471

Query: 598 --------SDGEENIGWSTVNLDEEKQQQD 619
                    + E    W  +  +E ++QQ+
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQE 501



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 132/627 (21%), Positives = 242/627 (38%), Gaps = 73/627 (11%)

Query: 162  RQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLA---E 218
            R+ E+ R+   +    R   Q L  +    ++     +   W +R R   +E+ L    +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 219  KRAKLLEEMDQEFGVSTLVEEEFGQRRQD----------LYSARDLQGLTVEHAIDSFRE 268
            K AK  +   QE       E E  +RRQ+          L   R+ Q L  +     FRE
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364

Query: 269  GETMILTLKDKG--VLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLA 326
             E   L  +++G   L+EE+       L  +ER  K +    K+   L   E E    L 
Sbjct: 1365 EE---LRHQEQGRKFLEEEQ------RLRRQERERKFL----KEEQQLRCQEREQ--QLR 1409

Query: 327  QQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRL 386
            Q + R    +  +    ER   FR E+       RER+  E   +LR +         +L
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469

Query: 387  ASEYLTPEEMVTFKKTKRR-----VKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRG 441
              E    EE    ++ + R      +++R++E++   R  +L     + +  +   +L  
Sbjct: 1470 LQE---REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 442  RGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQK 501
            + R+R   ++EE++   Q       R ++ D    EE         Q L   E + + + 
Sbjct: 1527 QQRQR-KFLQEEQQLRRQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRL 1583

Query: 502  QLEKGRRLRQ----LQQLQQL-RDSGEKVVEIVKKLESRQRGWEEDED--PERKGAIVFN 554
            + +K RR  Q    ++  QQL R  G++ +      + R R + EDE    ER+   +  
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLR-----QERDRKFREDEQLLQEREEQQLHR 1638

Query: 555  ATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEE---NIGWSTVNL 611
               +  + L E P       R+E+E+ +  +RD +         +GEE            
Sbjct: 1639 QERD-RKFLEEEPQL----RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693

Query: 612  DEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSA 671
             EE+QQ          L EE  + R         + +   ET  +++ R +   K L   
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL--- 1750

Query: 672  VYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYV--DETGRKLTPKEAFRQL 729
                E++    ++  ++   +   + F+E++  + + + + +   E+ RK   +E  RQ 
Sbjct: 1751 ----EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806

Query: 730  SHRFH---GKGSGKMKTERRMKKLDEE 753
                     +  GK + E    +L+E+
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQ 1833


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2081 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2140 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2256

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2313

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2363

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2364 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2403

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2460

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1846

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1847 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1899

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1947

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1948 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1986

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1987 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2041 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2154 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2201

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2202 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2247

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2248 EAENRAL 2254



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1346 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1400 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1564

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1621

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1742 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1838

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1899 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1944



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1133 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1186 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2085 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2144 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2260

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2317

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2367

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2368 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2407

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2464

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1797

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1850

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1851 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1903

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1951

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1952 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1990

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1991 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2045 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2158 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2205

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2206 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2251

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2252 EAENRAL 2258



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1350 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1403

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1404 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1453

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1568

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1625

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1685

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1745

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1746 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1842

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1903 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1948



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1137 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1190 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1245

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2081 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2140 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2256

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2313

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2363

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2364 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2403

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2460

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1793

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1846

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1847 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1899

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1947

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1948 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1986

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1987 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2041 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2154 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2201

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2202 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2247

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2248 EAENRAL 2254



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1346 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1400 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1564

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1621

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1742 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1838

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1899 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1944



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1133 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1186 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2049 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2108 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2224

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2281

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2331

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2332 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2371

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2428

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1761

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1814

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1815 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1867

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1915

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1916 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1954

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1955 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2009 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2122 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2169

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2170 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2215

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2216 EAENRAL 2222



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1314 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1367

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1368 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1417

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1532

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1589

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1649

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1709

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1710 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1806

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1867 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1912



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1101 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1154 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1209

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2218 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2277 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2393

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2450

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2500

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2501 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2540

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2597

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1930

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1983

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1984 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 2036

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 2084

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 2085 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 2123

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 2124 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2178 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2291 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2338

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2339 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2384

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2385 EAENRAL 2391



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1483 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1537 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1586

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1701

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1758

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1818

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1878

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1879 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1975

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 2036 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 2081



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1270 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1323 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1378

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2059 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2118 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2234

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2291

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2341

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2342 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2381

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2438

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1771

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1824

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1825 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1877

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1925

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1926 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1964

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1965 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2019 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2132 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2179

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2180 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2225

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2226 EAENRAL 2232



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1324 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1378 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1427

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1542

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1599

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1719

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1720 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1816

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1877 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1922



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1111 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1164 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1219

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2067 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2126 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2242

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2299

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2349

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2350 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2389

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2446

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1779

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1780 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1832

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1833 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1885

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1933

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1934 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 1972

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 1973 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2027 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2140 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2187

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2188 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2233

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2234 EAENRAL 2240



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1332 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1386 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1435

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1550

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1607

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1667

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1727

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1728 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1824

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1885 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1930



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1119 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1171

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1172 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1227

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 113/529 (21%), Positives = 205/529 (38%), Gaps = 81/529 (15%)

Query: 61   GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI 120
            GE  + RR AE EA  +    ER  A+   +  + E+     E  A ++  +  A+    
Sbjct: 2108 GEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166

Query: 121  EETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAK----- 175
            +E  +  A+      E  A++++     E           LRQ+ ++ ++L   +     
Sbjct: 2167 KEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224

Query: 176  ---EKRLLNQKLGKIKTLGED--------DPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
               +K LL+++L ++K    +        +  L      +E   +L K +  AE RA +L
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL-KARIEAENRALIL 2283

Query: 225  EEMD-------QEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK 277
             + D       +E      V EE  +       A  L+ L  E         E M   LK
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM---LK 2340

Query: 278  DK-GVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSK 336
            +K   +QE   +     L+ +++     + R+ + D     +++    LA++        
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED-----KEQMAQQLAEET-----QG 2390

Query: 337  YDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEM 396
            +   LE ER    +LE    A+ L+ R  E  RA+ R +                  E+ 
Sbjct: 2391 FQRTLEAERQR--QLEMSAEAERLKLRVAEMSRAQARAE------------------EDA 2430

Query: 397  VTFKKTKRRV-KKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKE 455
              F+K    + +K+ + E     +   +  L  Q Q  D  +    R R  ++E+E EKE
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE---RLREAIAELEREKE 2487

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ--------------VLEEDEAELE--L 499
             + Q       + E M    +E+         Q               +E+++A+LE   
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547

Query: 500  QKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            Q ++ K ++LR+ QQ QQ +   E+   +    E+R+R  E +E   RK
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/607 (22%), Positives = 237/607 (39%), Gaps = 101/607 (16%)

Query: 71   EAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKL 130
            + EA ++T  R+  +AE ++ R + E         AS   +  ++ S S +   +L A+ 
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAEA 1820

Query: 131  G-LKPLEVNAIKKEAGTKEEPVTADVINPMALRQREE----LREKLAAAKEKRLLNQKLG 185
            G  + L   A +  A  +E      +    A RQR E    L EKLAA  E         
Sbjct: 1821 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT------- 1873

Query: 186  KIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRR 245
            ++KT  E +  L +  A  ER R+L +++    +R   LEE   +      +EE   Q R
Sbjct: 1874 RLKT--EAEIALKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKAD--IEERLAQLR 1926

Query: 246  QDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVE 305
            +   S  + Q   VE  +   R+ E  IL LK             +       +AE  +E
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALK------------ASFEKAAAGKAELELE 1974

Query: 306  LRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLREREL 365
            L + + +    AED            ++ SK   ELE  R      E+       R RE 
Sbjct: 1975 LGRIRSN----AED------------TLRSKEQAELEAARQRQLAAEEER-----RRREA 2013

Query: 366  EEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLP 425
            EE     R+Q +SL+             EE+   K      +++R++ ++   R   L  
Sbjct: 2014 EE-----RVQ-KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067

Query: 426  LGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPG 485
               Q        RL+   +     V+++++ + Q L  + + ++ +    E    A    
Sbjct: 2068 EAAQ-------KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120

Query: 486  SPQVLEEDEAELELQKQLEKGRRLRQLQQLQ-QLRDSGEKVVEIVKK---LESRQRGWEE 541
                ++ +    + ++Q+E+  RL+Q  + Q Q R   +   E ++K    E+ +R   E
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 542  DEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGE 601
                 +K A   +A  E  +   E     L    + ++EL       E       E+D +
Sbjct: 2181 QAALRQKQAA--DAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLE-------ETDHQ 2228

Query: 602  ENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARV 661
            +N+      LDEE Q+    A +T    +   V   L +  +  +    L+      AR+
Sbjct: 2229 KNL------LDEELQR--LKAEATEAARQRSQVEEELFSVRVQMEELSKLK------ARI 2274

Query: 662  KAPNKSL 668
            +A N++L
Sbjct: 2275 EAENRAL 2281



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 133/654 (20%), Positives = 242/654 (37%), Gaps = 112/654 (17%)

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKE----KDLAEKRAKLLEEMDQE 230
            +E+RL  Q+        E+   L +  A +E+ RQL +     K  AE+ AK L++  QE
Sbjct: 1373 EEERLAEQQRA------EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1426

Query: 231  FGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLK-------DKGVLQ 283
              V          RR++       Q  +++  +   R+     +  K       ++  L+
Sbjct: 1427 EVV----------RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1476

Query: 284  EEEDV-LVNVNLVDKERAEKNVE-----LRKKKPD---YLPYAEDES------VDDLAQQ 328
             EE++ +V + L   ER     E     LR +  +       A++E+      V D +Q+
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 329  KPRS---ILSKYDEELEGERP--------HSFRLEQGGTADGLRERELEEIRAKLRLQAQ 377
            K ++   + S+   E E  R            RL+       LR+ E+E  R     Q Q
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-----QVQ 1591

Query: 378  SLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGS 437
                   R A   L  +     +KT +  + ++++   V    ++      Q  + +   
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--- 1648

Query: 438  RLRGRGRRRVSE----------VEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSP 487
            R R    R +            +  + E V Q         E      E E         
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708

Query: 488  QVLEEDEA---ELELQKQLEKG---RRLRQLQQLQQLR---DSGEKVVEIVKKLESRQRG 538
            Q + + E    ELE Q+QL +G   +RL   Q+L +LR   + GE+  +++++  +R + 
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1768

Query: 539  WEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER-SANGGSE 597
                   +R+        +E  +   E+     +  R E+E     E+ ++R  A  G  
Sbjct: 1769 EAAAATQKRQ-----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823

Query: 598  SDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQK 657
             +  E         +E K+Q+        + +E+    R  A  +L            +K
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQ-------LAEEDAARQRAEAERVL-----------AEK 1865

Query: 658  VARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETG 717
            +A +    +    A   +++K A +++  R  E   F +   E+   +    IE      
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925

Query: 718  RKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVAL 771
            RK +  E  RQ       KG  +  T R+ ++++EE L  K S      G   L
Sbjct: 1926 RKASDSELERQ-------KGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL 1971



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 52/221 (23%), Positives = 86/221 (38%), Gaps = 36/221 (16%)

Query: 364  ELEEIRAKLRLQAQSLSTV-----GPRLASEYL------------TPEEMVTFKKTKRRV 406
            +LE++R+   +  + L T+     G + A E L             P  +   + TK  +
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159

Query: 407  KKIRKKEKEVVVRADDLLPLGDQTQDG-----DFGSRLRGRGRRRVSEVEEEKEPVPQPL 461
            KK+R        +A+   P  D  +D      + G RL+ R   R  EVE  +E V Q L
Sbjct: 1160 KKLR-------AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212

Query: 462  PSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQLQQLRDS 521
                  +   D+   E          Q+    E+   L   L+  RR ++  Q   L DS
Sbjct: 1213 ERWQAVLAQTDVRQRELEQL----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1268

Query: 522  ---GEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEF 559
                E++ +    LE  +R  E+ E+ +R      NA  ++
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 153/743 (20%), Positives = 301/743 (40%), Gaps = 120/743 (16%)

Query: 87   EPSERRVK-REKRDDGYEAAASSKTS----SGDASSLSIEETNKL--------RAKLGLK 133
            E SER++K  E+ ++      SS       S +A    IE+ NK+         +KL   
Sbjct: 547  ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606

Query: 134  PLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLA-AAKEKRLLNQKLGKIKTLGE 192
              E   IKKE    +E             + EEL  +L    KE  LL +K+  +K   E
Sbjct: 607  EFEKRQIKKELEHYKEKG----------ERAEELENELHHLEKENELLQKKITNLKITCE 656

Query: 193  DDPWLDDTAAWIER-SRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSA 251
                L+   + +ER +R+L+K  D  +     LE +++E   ++ ++EE  + R+++ S 
Sbjct: 657  KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLELRRNVESL 713

Query: 252  R---------DLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKE--RA 300
            +          L+   +E   +  ++G  ++     K   ++ E + V+   +D E  R 
Sbjct: 714  KCASMKMAQLQLENKELESEKEQLKKGLELL-----KASFKKTERLEVSYQGLDIENQRL 768

Query: 301  EKNVELRKKKPDYLPYA-EDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADG 359
            +K +E   KK   L    +D  +++   QK    L    + LE     +  LEQ  +   
Sbjct: 769  QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828

Query: 360  LRERELEEIRAKLRLQAQSLST--------VGPRLASEYLTPEEMVTFKKTKRRVKKIRK 411
              +++LE+   +LR QA+   T        +G          +E+  +K++  R+K++ K
Sbjct: 829  KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888

Query: 412  KEKEVVVRA----DDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTR 467
            + KE+V RA      L+ L +        ++       +++   E+     + L  D+  
Sbjct: 889  ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948

Query: 468  VENMDISDEEEGGAPPPGSPQVLEEDEAELE--LQKQLEKGRRLRQ--------LQQLQQ 517
             ++     E +  +    S ++ EE  A LE  L++     ++LRQ         + L+Q
Sbjct: 949  TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1008

Query: 518  LRDSGEKVVEIVKKLESRQRGWEEDE---------------DPERKGAIVFNATSEFCRT 562
             +D  E++V+    +      WE +                + ER  A +          
Sbjct: 1009 RQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067

Query: 563  LGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQDFSA 622
            L ++ T     N   Q +++  +R         + S  E+N    T N   + +    ++
Sbjct: 1068 LKQLETQ----NNNLQAQILALQRQ--------TVSLQEQNTTLQTQNAKLQVENSTLNS 1115

Query: 623  SSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAID 682
             ST+++++         A LL+ Q+   LE   + V + +   KSL  ++  I+D   ++
Sbjct: 1116 QSTSLMNQN--------AQLLIQQSS--LENENESVIKEREDLKSLYDSL--IKDHEKLE 1163

Query: 683  DKYSRR-EEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKM 741
              + R+  EY               ++++E+ D   R       + QL      K  G++
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR-------YNQLL-----KQKGQL 1211

Query: 742  KTERRMKKLDEEALLKKMSSSDT 764
            +   +M K+++E +L +  + +T
Sbjct: 1212 EDLEKMLKVEQEKMLLENKNHET 1234


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 159/755 (21%), Positives = 306/755 (40%), Gaps = 143/755 (18%)

Query: 87   EPSERRVK-REKRDDGYEAAASSKTS----SGDASSLSIEETNKL--------RAKLGLK 133
            E SER++K  E+ ++      SS       S +A    IE+ NK+         +KL   
Sbjct: 547  ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606

Query: 134  PLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLA-AAKEKRLLNQKLGKIKTLGE 192
              E   IKKE    +E             + EEL  +L    KE  LL +K+  +K   E
Sbjct: 607  EFEKRQIKKELEHYKEKG----------ERAEELENELHHLEKENELLQKKITNLKITCE 656

Query: 193  DDPWLDDTAAWIER-SRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSA 251
                L+   + +ER +R+L+K  D  +     LE +++E   ++ ++EE  + R+++ S 
Sbjct: 657  KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLELRRNVESL 713

Query: 252  R---------DLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKE--RA 300
            +          L+   +E   +  ++G  ++     K   ++ E + V+   +D E  R 
Sbjct: 714  KCASMKMAQLQLENKELESEKEQLKKGLELL-----KASFKKTERLEVSYQGLDIENQRL 768

Query: 301  EKNVELRKKKPDYLPYA-EDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADG 359
            +K +E   KK   L    +D  +++   QK    L    + LE     +  LEQ  +   
Sbjct: 769  QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828

Query: 360  LRERELEEIRAKLRLQAQSLST--------VGPRLASEYLTPEEMVTFKKTKRRVKKIRK 411
              +++LE+   +LR QA+   T        +G          +E+  +K++  R+K++ K
Sbjct: 829  KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888

Query: 412  KEKEVVVRA-----------DDLL--PLGDQTQDGDFGS---RLRGRGRRRVSEVEEEKE 455
            + KE+V RA           +DL+   L  Q  + D       L   G  +   + +E+ 
Sbjct: 889  ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948

Query: 456  PVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELE--LQKQLEKGRRLRQ-- 511
                   +DD+R + ++   E    +    S ++ EE  A LE  L++     ++LRQ  
Sbjct: 949  -------TDDSRYKLLESKLE----STLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 997

Query: 512  ------LQQLQQLRDSGEKVVEIVKKLESRQRGWEEDE---------------DPERKGA 550
                   + L+Q +D  E++V+    +      WE +                + ER  A
Sbjct: 998  KTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056

Query: 551  IVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVN 610
             +          L ++ T     N   Q +++  +R         + S  E+N    T N
Sbjct: 1057 TLQAEKQALKTQLKQLETQ----NNNLQAQILALQRQ--------TVSLQEQNTTLQTQN 1104

Query: 611  LDEEKQQQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPS 670
               + +    ++ ST+++++         A LL+ Q+   LE   + V + +   KSL  
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQN--------AQLLIQQSS--LENENESVIKEREDLKSLYD 1154

Query: 671  AVYCIEDKMAIDDKYSRR-EEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQL 729
            ++  I+D   ++  + R+  EY               ++++E+ D   R       + QL
Sbjct: 1155 SL--IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR-------YNQL 1205

Query: 730  SHRFHGKGSGKMKTERRMKKLDEEALLKKMSSSDT 764
                  K  G+++   +M K+++E +L +  + +T
Sbjct: 1206 L-----KQKGQLEDLEKMLKVEQEKMLLENKNHET 1235


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 108/453 (23%), Positives = 189/453 (41%), Gaps = 72/453 (15%)

Query: 207 SRQLQKEKDLAEK---RAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAI 263
           S ++QK K  A K   + K +EE+ +E    T VE+E  +  + L +      +T E A+
Sbjct: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEE----TKVEDEKSEMEEALTA------ITEELAV 482

Query: 264 DSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVD 323
            S +E +      K++    EEE+V    + V     E   E  +K        E+E   
Sbjct: 483 -SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK--------EEEEGQ 533

Query: 324 DLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELE--EIRAKLRLQAQSLST 381
           +  +++     S   EE   E+  S   E+G   +G  E E E  E  AK   + +  S 
Sbjct: 534 EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS- 592

Query: 382 VGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRG 441
                  E  T EE+V   K ++      +K K  V ++    P+ ++ +     S +  
Sbjct: 593 ------EEVATKEELVADAKVEKP-----EKAKSPVPKS----PVEEKGKSPVPKSPVEE 637

Query: 442 RGRRRV--SEVEEE-KEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELE 498
           +G+  V  S VEE+ K PVP+    +  +        EE+  +P P SP  +EE +++ E
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP--VEEAKSKAE 695

Query: 499 LQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDED-PERKGA---IVFN 554
           + K  +K              +  EK V+   K E  ++  E+ +D PE+K A   +   
Sbjct: 696 VGKGEQK--------------EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 741

Query: 555 ATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG---------EENIG 605
           A +E       +  +     +EE + L   +  E+    GGSE +G         +E+I 
Sbjct: 742 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 801

Query: 606 WSTVNLDEEKQQQDFSASSTTILDEEPIVNRGL 638
            +     +E+ +Q+     +   +E+ +V  GL
Sbjct: 802 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGL 834



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 145/784 (18%), Positives = 296/784 (37%), Gaps = 99/784 (12%)

Query: 31  RHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSE 90
           R  E +    R  GS  SG       R +   RGS    + +  RS    R    A  S 
Sbjct: 16  RVTETRSSFSRVSGSPSSG------FRSQSWSRGSPSTVSSSYKRSMLAPR---LAYSSA 66

Query: 91  RRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKK----EAGT 146
                E   D  ++++     SG      +  +N+     GL       I+K    E   
Sbjct: 67  MLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQN 126

Query: 147 KEEPVTADVINPMALRQREELREKLAAAKEKRL---------LNQKLGKIKTLGEDDPWL 197
           KE  + A++    ALRQ++    +L  A ++ +         +N +  +++   + D   
Sbjct: 127 KE--IEAEI---QALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQL--DSDHLE 179

Query: 198 DDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYS-ARDLQG 256
           +D     ER  +  + +D  E   + L +  +E   ++LV+ E  ++ Q L      L+ 
Sbjct: 180 EDIHRLKERFEEEARLRDDTEAAIRALRKDIEE---ASLVKVELDKKVQSLQDEVAFLRS 236

Query: 257 LTVEHAIDSFREGETMILTLKDKGVLQEE-EDVLVNVNLVDKERAEKNVELRKK--KPDY 313
              E   D   + +   +T++ K  L+ +    L  +    +  +++N+   ++  K  Y
Sbjct: 237 NHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRY 296

Query: 314 LPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQ-GGTADGLRERELEEIRAKL 372
               E    +  A +  +  +++Y  +L+ +   S  LE   GT + L ER+L +I  + 
Sbjct: 297 AKLTEAAEQNKEAIRSAKEEIAEYRRQLQSK---SIELESVRGTKESL-ERQLSDIEERH 352

Query: 373 RLQAQSLSTVGPRLASEYL-TPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQ 431
                S      +L +E   T  EM    +  + +  + K   ++ + A   L  G++T+
Sbjct: 353 NHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNV-KMALDIEIAAYRKLLEGEETR 411

Query: 432 DGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLE 491
              F   + G        +   + P+         +VE   +  + +         +++E
Sbjct: 412 FSTFAGSITG-------PLYTHRPPITISSKIQKPKVEAPKLKVQHKF------VEEIIE 458

Query: 492 EDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAI 551
           E + E E               ++++   +  + + +  K E ++   E++E+PE +   
Sbjct: 459 ETKVEDEKS-------------EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 552 VFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNL 611
           V    S    T  E+      G +EE+E   + E ++E + +  +E  G E  G S    
Sbjct: 506 VAAKKSPVKATAPEVKEE--EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 612 DEEKQ---QQDFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAP---- 664
            E+++   + +         +E+ +  +    A    + + + +  V+K  + K+P    
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA---TKEELVADAKVEKPEKAKSPVPKS 620

Query: 665 ------NKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGR 718
                    +P +    + K  +       +      +   E+ G  P V    V+E  +
Sbjct: 621 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP-VSKSPVEEKAK 679

Query: 719 KLTPKEAFRQLSHRFH-GKGSGKMKTERRMKKLDEEALLKKMSS--SDTPLGTVALLQEK 775
              PK    +   +   GKG  K + E+ +K+  +E  ++K      D P        EK
Sbjct: 680 SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP--------EK 731

Query: 776 QKAQ 779
           +KA+
Sbjct: 732 KKAE 735



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 68/321 (21%), Positives = 124/321 (38%), Gaps = 44/321 (13%)

Query: 5   KKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERG 64
           K+  GEKE           G  E+       K  +   GGS   G   ++   +  GE  
Sbjct: 521 KEEEGEKEEEE--------GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572

Query: 65  SGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETN 124
           +   G EAEA+      E+S+   ++  +  + + +  E A S    S       +EE  
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS------PVEEKG 626

Query: 125 KLRA------KLGLKPLEVNAI--KKEAGTKEEPVTADVINPMALRQREELREKLAAAK- 175
           K         + G  P+  + +  K ++   + PV     +P++    EE + K    K 
Sbjct: 627 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKS 685

Query: 176 --EKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKR---AKLLEEMDQE 230
             E+     ++GK +   E++  + +     +  ++ +K KD+ EK+   + + EE   E
Sbjct: 686 PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAE 745

Query: 231 F-----GVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVL-QE 284
                  V   +E+E  +  + L   ++ +    E    S  EG        DKG     
Sbjct: 746 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGG--SEEEG-------SDKGAKGSR 796

Query: 285 EEDVLVNVNLVDKERAEKNVE 305
           +ED+ VN  +  KE  E+  +
Sbjct: 797 KEDIAVNGEVEGKEEVEQETK 817



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 64/303 (21%), Positives = 119/303 (39%), Gaps = 35/303 (11%)

Query: 2   GSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGS--GGSGGERRKRSRER 59
           GSS+K  GE+E   T A A    A  +  +  E K  +  +       +  E+ ++++  
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616

Query: 60  GGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLS 119
             +     +G     +S    + +S   P  +    EK       +   +      S   
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKS---PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 673

Query: 120 IEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRL 179
           +EE  K ++ +   P+E    K E G  E              Q+EE  +++  A ++  
Sbjct: 674 VEE--KAKSPVPKSPVEEAKSKAEVGKGE--------------QKEEEEKEVKEAPKEEK 717

Query: 180 LNQKLGKIKTLGE----DDPWLDDTAA---WIERSRQLQKEKDLAEKRAKLLEEMDQEFG 232
           + +K  K K + E    + P  ++  A    I +S ++  EK+  E+   L +E ++E  
Sbjct: 718 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKA 777

Query: 233 VSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREG-ETMILTLKDKGVLQEEEDVLVN 291
                 EE G  +    S ++      + A++   EG E +    K+KG  +EEE  +V 
Sbjct: 778 GGEGGSEEEGSDKGAKGSRKE------DIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 831

Query: 292 VNL 294
             L
Sbjct: 832 NGL 834


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 108/453 (23%), Positives = 189/453 (41%), Gaps = 72/453 (15%)

Query: 207 SRQLQKEKDLAEK---RAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAI 263
           S ++QK K  A K   + K +EE+ +E    T VE+E  +  + L +      +T E A+
Sbjct: 57  SSKIQKPKVEAPKLKVQHKFVEEIIEE----TKVEDEKSEMEEALTA------ITEELAV 106

Query: 264 DSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVD 323
            S +E +      K++    EEE+V    + V     E   E  +K        E+E   
Sbjct: 107 -SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK--------EEEEGQ 157

Query: 324 DLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELE--EIRAKLRLQAQSLST 381
           +  +++     S   EE   E+  S   E+G   +G  E E E  E  AK   + +  S 
Sbjct: 158 EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS- 216

Query: 382 VGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRG 441
                  E  T EE+V   K ++      +K K  V ++    P+ ++ +     S +  
Sbjct: 217 ------EEVATKEELVADAKVEKP-----EKAKSPVPKS----PVEEKGKSPVPKSPVEE 261

Query: 442 RGRRRV--SEVEEE-KEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELE 498
           +G+  V  S VEE+ K PVP+    +  +        EE+  +P P SP  +EE +++ E
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP--VEEAKSKAE 319

Query: 499 LQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDED-PERKGA---IVFN 554
           + K  +K              +  EK V+   K E  ++  E+ +D PE+K A   +   
Sbjct: 320 VGKGEQK--------------EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365

Query: 555 ATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDG---------EENIG 605
           A +E       +  +     +EE + L   +  E+    GGSE +G         +E+I 
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425

Query: 606 WSTVNLDEEKQQQDFSASSTTILDEEPIVNRGL 638
            +     +E+ +Q+     +   +E+ +V  GL
Sbjct: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGL 458



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 68/321 (21%), Positives = 124/321 (38%), Gaps = 44/321 (13%)

Query: 5   KKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERG 64
           K+  GEKE           G  E+       K  +   GGS   G   ++   +  GE  
Sbjct: 145 KEEEGEKEEEE--------GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 196

Query: 65  SGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETN 124
           +   G EAEA+      E+S+   ++  +  + + +  E A S    S       +EE  
Sbjct: 197 AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS------PVEEKG 250

Query: 125 KLRA------KLGLKPLEVNAI--KKEAGTKEEPVTADVINPMALRQREELREKLAAAK- 175
           K         + G  P+  + +  K ++   + PV     +P++    EE + K    K 
Sbjct: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKS 309

Query: 176 --EKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKR---AKLLEEMDQE 230
             E+     ++GK +   E++  + +     +  ++ +K KD+ EK+   + + EE   E
Sbjct: 310 PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAE 369

Query: 231 F-----GVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVL-QE 284
                  V   +E+E  +  + L   ++ +    E    S  EG        DKG     
Sbjct: 370 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGG--SEEEG-------SDKGAKGSR 420

Query: 285 EEDVLVNVNLVDKERAEKNVE 305
           +ED+ VN  +  KE  E+  +
Sbjct: 421 KEDIAVNGEVEGKEEVEQETK 441



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 52/265 (19%), Positives = 103/265 (38%), Gaps = 30/265 (11%)

Query: 531 KLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEER 590
           K E ++   E++E+PE +   V    S    T  E+      G +EE+E   + E ++E 
Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE--EGEKEEEEGQEEEEEEDEG 166

Query: 591 SANGGSESDGEENIGWSTVNLDEEKQ---QQDFSASSTTILDEEPIVNRGLAAALLLCQN 647
           + +  +E  G E  G S     E+++   + +         +E+ +  +    A    + 
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA---TKE 223

Query: 648 KGLLETTVQKVARVKAP----------NKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQD 697
           + + +  V+K  + K+P             +P +    + K  +       +      + 
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283

Query: 698 FKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFH-GKGSGKMKTERRMKKLDEEALL 756
             E+ G  P V    V+E  +   PK    +   +   GKG  K + E+ +K+  +E  +
Sbjct: 284 PVEEKGKSP-VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342

Query: 757 KKMSS--SDTPLGTVALLQEKQKAQ 779
           +K      D P        EK+KA+
Sbjct: 343 EKKEEKPKDVP--------EKKKAE 359



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 64/303 (21%), Positives = 119/303 (39%), Gaps = 35/303 (11%)

Query: 2   GSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGS--GGSGGERRKRSRER 59
           GSS+K  GE+E   T A A    A  +  +  E K  +  +       +  E+ ++++  
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240

Query: 60  GGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLS 119
             +     +G     +S    + +S   P  +    EK       +   +      S   
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKS---PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297

Query: 120 IEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRL 179
           +EE  K ++ +   P+E    K E G  E              Q+EE  +++  A ++  
Sbjct: 298 VEE--KAKSPVPKSPVEEAKSKAEVGKGE--------------QKEEEEKEVKEAPKEEK 341

Query: 180 LNQKLGKIKTLGE----DDPWLDDTAA---WIERSRQLQKEKDLAEKRAKLLEEMDQEFG 232
           + +K  K K + E    + P  ++  A    I +S ++  EK+  E+   L +E ++E  
Sbjct: 342 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKA 401

Query: 233 VSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREG-ETMILTLKDKGVLQEEEDVLVN 291
                 EE G  +    S ++      + A++   EG E +    K+KG  +EEE  +V 
Sbjct: 402 GGEGGSEEEGSDKGAKGSRKE------DIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455

Query: 292 VNL 294
             L
Sbjct: 456 NGL 458


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 147/782 (18%), Positives = 288/782 (36%), Gaps = 128/782 (16%)

Query: 105 AASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPV--TADVINPMALR 162
           ++S+ ++    SSLS E+   L  +L      +  +++E   K E +  T   ++ + L 
Sbjct: 231 SSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLE 290

Query: 163 QREELREKLAAAKEKRL----------LNQKLGKIKTLGED------------------D 194
            ++  +E +  A + R           L +K  +++ L  +                  +
Sbjct: 291 LQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARME 350

Query: 195 PWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDL 254
              +D    IE    L+++   A  R   + E+++E         +   +  DL   RD 
Sbjct: 351 ELREDNIILIETKAMLEEQLTAARARGDKVHELEKE-------NLQLKSKLHDLELDRDT 403

Query: 255 QGLTVEHAIDSFREGETMILTLKDKGVLQEE-------EDVLVNVNLVDKERAEKNVELR 307
               +E  ++     E M+L +  K  + E        E +  N +L D  R     EL 
Sbjct: 404 DKKRIEELLE-----ENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELN 458

Query: 308 KKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEE 367
           +     +   E E+                   ++G R  S  LE+ G   G  E+E  +
Sbjct: 459 ECASSRILKLEKEN-------------QSLQSTIQGLRDASLVLEESGLKCGELEKENHQ 505

Query: 368 IRAKL-RLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPL 426
           +  K+ +LQ Q        L  E  + +++ T  +   R K+  + + E + +AD    +
Sbjct: 506 LSKKIEKLQTQ--------LEREKQSNQDLETLSEELIREKEQLQSDMETL-KADKARQI 556

Query: 427 GDQTQDGDFGSR----LRGRGR----RRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEE 478
            D  Q+ D  +R    LR R +     R+ +VE+E + + Q +   + ++  ++    + 
Sbjct: 557 KDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQL 616

Query: 479 GGAPPPGSPQVLEEDEAELELQK-QLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQR 537
                    +    ++ E ELQ+ Q E GR  R++  L+   +  E +    + L+   R
Sbjct: 617 HRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENR 676

Query: 538 GWEEDEDPERKGAIVF----------NATSEFCRTLGEIPTYGLAGNREEQEELMDFERD 587
              +  D  +  ++            +A +   R L E   +      + + E    ER+
Sbjct: 677 TLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLERE 736

Query: 588 EERSANG-------GSESDGEENIGWSTVNLDEEKQQQDFSASSTTILDEEPIVNRGLAA 640
           +E            G +S+  E + + +V+ +  + QQ   +SS      E  +    A 
Sbjct: 737 KEELRKNVDLLKALGKKSERLE-LSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAE 795

Query: 641 ALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKE 700
              L ++   L     ++   +   K+L   V  +E      DK    +E +   Q  + 
Sbjct: 796 RQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEK-----DKKLLEKEAKRLWQQVEL 850

Query: 701 KDGYKPD--VKIEYVDETGRKLTPKEAF---------------RQLSHRF--HGKGSGKM 741
           KD    D   K+  V++  R L  + A                R L+ +   H +    +
Sbjct: 851 KDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTL 910

Query: 742 KTERRMKKLDEEALLKKMSSSDTPLGTVAL-----LQEKQKAQKTPYIVLSGSGKSMNAN 796
           + +  ++KL  + L  ++      L  V L     LQE      T Y +L G  +S    
Sbjct: 911 REDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKT 970

Query: 797 TI 798
           T+
Sbjct: 971 TL 972



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 56/275 (20%), Positives = 121/275 (44%), Gaps = 26/275 (9%)

Query: 155  VINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEK 214
            V+  +  +Q     +KL+   EK  LN++L     L EDD   D     +E   +   + 
Sbjct: 915  VLEKLKSQQLSSELDKLSQELEKVGLNREL----LLQEDDSGSDTKYKILEGRNESALKT 970

Query: 215  DLAEKRAKLL---EEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFRE--G 269
             LA K  K++    +M+++  ++  +E E    +++  + R  QG   +H  +SF+   G
Sbjct: 971  TLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQG-EGQHLQNSFKHPAG 1029

Query: 270  ETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQK 329
            +T       +      ++  + +  V K+RA   +EL +        AE + + +  Q  
Sbjct: 1030 KTAASHQGKEAWGPGHKEATMELLRV-KDRA---IELERNNAAL--QAEKQLLKEQLQHL 1083

Query: 330  PRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASE 389
                ++   + L  ++  +F  E   T        L+   AKL+++  +LS+    L ++
Sbjct: 1084 ETQNVTFSSQILTLQKQSAFLQEHNTT--------LQTQTAKLQVENSTLSSQSAALTAQ 1135

Query: 390  YLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLL 424
            Y   +   T K+T+   + ++++++++    + LL
Sbjct: 1136 YTLLQNHHTAKETEN--ESLQRQQEQLTAAYEALL 1168


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 160/722 (22%), Positives = 306/722 (42%), Gaps = 88/722 (12%)

Query: 67   RRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSI-EETNK 125
            ++G E + +      +  Q   +E   KR+K D   +    +K S GD   + + E+ +K
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL-HAKVSEGDRLRVELAEKASK 1284

Query: 126  LRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQ------REELREKLAAAKEKRL 179
            L+ +L      V+ + +EA  K      D  +  +  Q      +EE R+KL  +   R 
Sbjct: 1285 LQNELD----NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340

Query: 180  LNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEK-DLAEKRAKLLEEMDQEFGVSTLVE 238
            L ++   ++   E++          E  + L+K+   L  + A   +++D + G    +E
Sbjct: 1341 LEEEKNSLQEQQEEEE---------EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE 1391

Query: 239  EEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKE 298
            E    +++ L  A  L     E A+ ++ + E      K K  LQ+E D L  V+L  + 
Sbjct: 1392 EA---KKKLLKDAEALSQRLEEKAL-AYDKLE------KTKNRLQQELDDLT-VDLDHQR 1440

Query: 299  RAEKNVELRKKKPDYLPYAEDESVDD-LAQQKPRSILSKYDEELEGERPHSFRLEQGGTA 357
            +   N+E ++KK D L  AE++S+    A+++ R+     ++E +     +  LE+   A
Sbjct: 1441 QVASNLEKKQKKFDQL-LAEEKSISARYAEERDRAEAEAREKETKA-LSLARALEEALEA 1498

Query: 358  DGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVV 417
                ER+ +++RA +     S   VG  +    L   +    ++ +    ++ + E E+ 
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSKRALEQQVEEMRTQLEELEDELQ 1556

Query: 418  VRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEE 477
               D  L L    Q       ++ +  R +   +E+ E   + L      +E  ++ DE 
Sbjct: 1557 ATEDAKLRLEVNMQ------AMKAQFERDLQTRDEQNEEKKRLLIKQVRELE-AELEDER 1609

Query: 478  EGGAPPPGSPQVLEEDEAELELQKQLEKGRR---LRQLQQLQ-QLRDSGEKVVEIVKKLE 533
            +  A    S + +E D  +LE Q +     R   ++QL++LQ Q++D      E+ +   
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR---ELEEARA 1666

Query: 534  SRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQE--ELMDFERDEERS 591
            SR   + + ++ E+K   + +  +E  +   E+ +   A    EQE  EL D   +   S
Sbjct: 1667 SRDEIFAQSKESEKK---LKSLEAEILQLQEELASSERARRHAEQERDELAD---EITNS 1720

Query: 592  ANGGSE-SDGEENIGWSTVNLDEEKQQQDFSAS-------STTILDEEPIVNRGLAAALL 643
            A+G S   D +  +      L+EE +++  +          TT+  +   +N  LAA   
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL--QVDTLNAELAAERS 1778

Query: 644  LCQNKGLLETTVQKVAR-VKAPNKSLPSAVYCIEDKMAIDDKYSRREEYRGFTQDFKEKD 702
              Q        +++  + +KA  + L  AV     K       S  E   G  ++  E++
Sbjct: 1779 AAQKSDNARQQLERQNKELKAKLQELEGAV-----KSKFKATISALEAKIGQLEEQLEQE 1833

Query: 703  GYKPDVKIEYVDETGRKLTPKEAFRQL-SHRFHG--------KGSGKMK-TERRMKKLDE 752
              +     + V  T +KL  KE F Q+   R H         K + +MK  +R++++ +E
Sbjct: 1834 AKERAAANKLVRRTEKKL--KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEE 1891

Query: 753  EA 754
            EA
Sbjct: 1892 EA 1893



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 110/586 (18%), Positives = 241/586 (41%), Gaps = 58/586 (9%)

Query: 211  QKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGE 270
            ++E++L  K  +LL+  +++  V   +EE   ++ Q L   +++    ++   + F E E
Sbjct: 849  RQEEELQAKDEELLKVKEKQTKVEGELEE-MERKHQQLLEEKNILAEQLQAETELFAEAE 907

Query: 271  TMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAED--ESVDDLAQQ 328
             M   L  K   QE E++L ++    +E  E+N  L+ +K     + +D  E +D+    
Sbjct: 908  EMRARLAAKK--QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965

Query: 329  KPRSILSKYDEELEGER-PHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLA 387
            + +  L K   E + ++      L +   +  ++E++L E R         ++    +LA
Sbjct: 966  RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR---------IAECSSQLA 1016

Query: 388  SEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRV 447
             E          ++  + + KIR K++ ++   ++ L   ++T+       L    R+  
Sbjct: 1017 EE----------EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ-----ELEKAKRKLD 1061

Query: 448  SEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGR 507
             E  + ++ + +     D     +   +EE  GA   G  + L ++ A L++ ++L+   
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA-LKVVRELQA-- 1118

Query: 508  RLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDP---ERKGAIVFNATSEFCRTLG 564
                  Q+ +L++  E       K E ++R   E+ +    E +  +   A  +  RT  
Sbjct: 1119 ------QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172

Query: 565  EIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWST-VNLDEEKQQQDFSAS 623
            E     L    EE+ +  + +  + R  +  +  +  E +  +     + EK +Q     
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232

Query: 624  STTILDEEPIVNRGLAAALLLCQNKGLLETTVQKV-ARVKAPNK---SLPSAVYCIEDKM 679
            +  +  E  ++ +  A +      +  L+  VQ++ A+V   ++    L      +++++
Sbjct: 1233 NKELACEVKVLQQVKAESE---HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289

Query: 680  AIDDKYSRREEYRG--FTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKG 737
                      E +G  F +D    +    D +    +ET +KL      RQL    +   
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349

Query: 738  SGKMKTERRMKKLDEEALLKKMSSSDT------PLGTVALLQEKQK 777
              + + E   K L+++ L  +   +DT       LGT+  L+E +K
Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 131/620 (21%), Positives = 218/620 (35%), Gaps = 102/620 (16%)

Query: 27  EQPPRHR----EHKKHKH-RSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGR 81
           + PPRHR    E  +H H R+  S     ERR+ +R +       R   E E   S+   
Sbjct: 386 QSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445

Query: 82  ERSQAEPSERRVKREKRD-----------------DGYEAAASSKTSSGDASSLSIEETN 124
            R   EP + R +R+ RD                 +  + +  +K S     S S  + +
Sbjct: 446 HRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH 505

Query: 125 KLRAKLGLKPLEVNAIKKEAGT-------KEEPVTADVINPMALRQREELRE-------- 169
             R + G           E          +EE    ++ N      R E+R         
Sbjct: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565

Query: 170 KLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQ 229
           ++    EK     +  +I +   +  + D   +W  RS     E+D   +R    +  D 
Sbjct: 566 RVPELPEKGSRGSRGSQIDSHSSNSNYHD---SWETRSSY--PERDRYPERDNRDQARDS 620

Query: 230 EFGVSTLVEEEFGQRRQDLYSARDL--QGLTVEHAIDSFREGETMILTLKDKGVLQEEED 287
            F       +    R +D   +  +  QG   E   D  RE   +     D+  + +  D
Sbjct: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRV-----DR--VDDRRD 673

Query: 288 VLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGERPH 347
                   ++ER  +    R+++ D     E E   + A+++ R    + D E + +R H
Sbjct: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733

Query: 348 SFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVK 407
                     D  RERE E  R K R + +                EE    ++ +R  +
Sbjct: 734 ----------DRERERERERDREKERERER----------------EERERERERERERE 767

Query: 408 KIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTR 467
           + R++E+E     D      ++ +  D+  + +GR  RR  E  EE      P    D R
Sbjct: 768 RERERERERARERDK-----ERERQRDWEDKDKGRDDRR--EKREEIREDRNPRDGHDER 820

Query: 468 VENMDISDEEEGGAPPPGSPQVLEEDEAELEL----QKQLEKGRRLRQLQQLQQLRDSGE 523
                     EG   P  SP+   E   + +       + EK R L Q+ + Q+ R    
Sbjct: 821 KSKKRY--RNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSP 878

Query: 524 KVVEIVKKLESRQRGW-EEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELM 582
             +      E RQ  W EED  PERK +       E    +  +        + EQ E++
Sbjct: 879 SHL-----TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSV------DKQREQTEIL 927

Query: 583 DFERDEERSANGGSESDGEE 602
           +  R   +   G  +S+  E
Sbjct: 928 ESSRMRAQDIIGHHQSEDRE 947


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 113/492 (22%), Positives = 209/492 (42%), Gaps = 71/492 (14%)

Query: 66   GRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNK 125
            G RGA A A +     +R + E +   + +EK D   +  A     +       +   +K
Sbjct: 907  GLRGALAAAEA-----KRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSK 961

Query: 126  LRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQRE------ELRE-----KLAAA 174
            ++ +  +K L       E    EE V AD    +A R+R+      EL++     KL  A
Sbjct: 962  VQLEGKVKELS------ERLEDEEEVNAD----LAARRRKLEDECTELKKDIDDLKLTLA 1011

Query: 175  KEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQ------------LQKEKDLAEKRAK 222
            K ++       K+K L E+   LD++ A + + ++            LQ E+D      K
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK 1071

Query: 223  LLEEMDQEF-GVSTLVEEEFGQRRQDLYSARDLQG---LTVEHAIDSFREGETMILTLKD 278
                ++Q+   +   +E+E   R     + R L+G   LT E   D+ ++ +     L++
Sbjct: 1072 AKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ----QLEE 1127

Query: 279  KGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYD 338
            K  L++++  L  ++L  ++      +++KK  +    AE+   +  A++  R+ + K  
Sbjct: 1128 K--LKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR 1185

Query: 339  EELEGERPH-SFRLEQGGTA-----DGLRERELEEIRAKLRLQAQSL---STVGPRLASE 389
             E   E    S RLE+ G A     +G R+RE E  R +  L+  +L   +TV      +
Sbjct: 1186 AEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQ 1245

Query: 390  YLTPEEMVTFKKTKRRVK-KIRKKEKEVVVRADDLLP-LGDQTQDGDFGSRLRGRGRRRV 447
                 E+     + +RV+ K+ K++ E+ +  DDL   +   T+      +L      ++
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305

Query: 448  SEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGR 507
            SE + + E + + L    T+   +     E          ++LEE E    L  QL +G+
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGE--------LSRLLEEKEC---LISQLSRGK 1354

Query: 508  RLRQLQQLQQLR 519
             L   Q L++LR
Sbjct: 1355 AL-AAQSLEELR 1365



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 61/337 (18%), Positives = 137/337 (40%), Gaps = 18/337 (5%)

Query: 208  RQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFR 267
            R  Q E++LA  RA+L   +      +    +E  +    +   ++   L ++   D+  
Sbjct: 890  RSAQAEEELAALRAEL-RGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948

Query: 268  EGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQ 327
            + E     L    V  E +   ++  L D+E    ++  R++K +       + +DDL  
Sbjct: 949  DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDL-- 1006

Query: 328  QKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLA 387
               +  L+K ++E +        L +   A       L+E  A+L  + ++L     +  
Sbjct: 1007 ---KLTLAKAEKEKQATENKVKNLTEEMAA-------LDESVARLTKEKKALQEAHQQAL 1056

Query: 388  SEYLTPEEMVT-FKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRR 446
             +    E+ V+   K K R+++ + ++ E  +  +  L +  +         L+   +  
Sbjct: 1057 GDLQAEEDRVSALTKAKLRLEQ-QVEDLECSLEQEKKLRMDTERAKRKLEGDLK-LTQES 1114

Query: 447  VSEVEEEKEPVPQPLPSDDTRVENMD--ISDEEEGGAPPPGSPQVLEEDEAELELQKQLE 504
            V++  ++K+ + + L   D+ +  +   + DE+  GA      + L+    ELE + + E
Sbjct: 1115 VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174

Query: 505  KGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEE 541
            +  R R  +Q  +     E++ E +++      G  E
Sbjct: 1175 RAARARVEKQRAEAARELEELSERLEEAGGASAGQRE 1211



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 116/524 (22%), Positives = 207/524 (39%), Gaps = 106/524 (20%)

Query: 33   REHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEA---RSSTHGRERSQAEPS 89
            RE ++   R   +GG+   +R+  R+R  E G  RR  E  A    ++     R QAE +
Sbjct: 1190 RELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGA 1249

Query: 90   ----ERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAG 145
                E+    ++     E   S      D  + ++E   + +A          + +K   
Sbjct: 1250 AELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA----------SAEKLCR 1299

Query: 146  TKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKT-LGEDDPWLDDTAAWI 204
            T E+ ++   I      + EEL+ +LA A  +R      G+++T  GE    L++    I
Sbjct: 1300 TYEDQLSEAKI------KVEELQRQLADASTQR------GRLQTESGELSRLLEEKECLI 1347

Query: 205  ERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAID 264
                QL + K LA   A+ LEE+ ++      +EEE   +              + HA+ 
Sbjct: 1348 S---QLSRGKALA---AQSLEELRRQ------LEEESKAKS------------ALAHAVQ 1383

Query: 265  SFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDD 324
            + R          D  +L+E+ +          E AE   EL++     L    +  V  
Sbjct: 1384 ALRH---------DCDLLREQHE----------EEAEAQAELQR-----LLSKANAEVAQ 1419

Query: 325  LAQQKPRSILSKYDEELEGERPHSFRL---EQGGTADGLRERELEEIRAKLRLQAQSLST 381
               +     + + +E  E ++  + RL   E+G  A   +   LE  +AKLRLQ +S   
Sbjct: 1420 WRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLE--KAKLRLQTESEDV 1477

Query: 382  VGPRLASEYLTPEEMVTFKKTK--RRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRL 439
                L  E  T       KK +   R  + R++++E + R         + +     SR 
Sbjct: 1478 T---LELERATSAAAALDKKQRHLERALEERRRQEEEMQR---------ELEAAQRESRG 1525

Query: 440  RGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAEL-- 497
             G    R+    EE     + L  ++  ++  +ISD  +  +    S Q LE+ +  L  
Sbjct: 1526 LGTELFRLRHGHEEALEALETLKRENKNLQE-EISDLTDQVSLSGKSIQELEKTKKALEG 1584

Query: 498  ---ELQKQLEKGRRLRQLQQLQQLR---DSGEKVVEIVKKLESR 535
               E+Q  LE+     +L++ + LR   +  +   E+ +KL  +
Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1628


>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
          Length = 947

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 132/681 (19%), Positives = 246/681 (36%), Gaps = 147/681 (21%)

Query: 9   GEKEAAGTTAAAGTGGATEQPPRHREHKK--HKHRSGGSGGSGGERRKRSRERGGERGSG 66
           GE   AG  +    GGA + PP      K     + GGSGG G      S   G   G+G
Sbjct: 171 GEGGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTG 230

Query: 67  RRGAEAEARSSTHGRERS-------QAEPSERRVKREKRDDGYEAAASSKTSSGDASS-- 117
            R + +       G   S       Q+E  +  +K+E+      AA     + G +SS  
Sbjct: 231 SRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHAKNGGGSSSRS 290

Query: 118 ------------LSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQRE 165
                       L++   + + A                G +     +   +P  L+++E
Sbjct: 291 SPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQE 350

Query: 166 ELREKLAAAKEK-RLLNQKLGKIKTLGED--DPWLDDTAAWIERSRQLQKEKDLAEKRAK 222
           E++E++   +E+   L  ++ +++T  ++  D + ++ A  ++   +++ E + A K  +
Sbjct: 351 EMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQLQ---EMRHELERANKNCR 407

Query: 223 LLEEMDQEFGVSTLVEEEFGQ--------RRQDLYSARDLQGLTVEHAIDSFREGET--- 271
           +L+   ++     L   + G+          QDL  A+D+  + + H +++  E  T   
Sbjct: 408 ILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDV-SVRLHHELENVEEKRTTTE 466

Query: 272 ---------MILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESV 322
                    +I     K  LQ E + +  ++L  K R  K++   +KK    P  ED   
Sbjct: 467 DENEKLRQQLIEVEIAKQALQNELEKMKELSL--KRRGSKDLPKSEKKAQQTPTEEDN-- 522

Query: 323 DDLAQQ----KPRSIL------------SKYDEELEGERPHSFRLEQ---GGTADGLRER 363
           +DL  Q    K  + L             +++ EL+  R     L+     G A G    
Sbjct: 523 EDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGDLDSPLPKGEAGGPPST 582

Query: 364 ELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDL 423
              E++ +LRL  +  + +G                    R++ ++  + + +    DDL
Sbjct: 583 REAELKLRLRLVEEEANILG--------------------RKIVELEVENRGLKAELDDL 622

Query: 424 LPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGA-- 481
                  +  DF        R +   + E ++ +   L  D+T +   +++D EE     
Sbjct: 623 -------RGDDFNGSANPLMREQSESLSELRQHL--QLVEDETELLRRNVADLEEQNKRI 673

Query: 482 ---------PPPGSPQVLEEDEAELE-LQKQLEKGR--------RLRQLQQLQQLRDSGE 523
                       G       D A+ E LQ++L+  R        ++ QLQ   ++  S  
Sbjct: 674 TAELNKYKYKSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNM 733

Query: 524 KVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMD 583
           +  ++   L    RG   D D E                         AG +E  ++   
Sbjct: 734 QRYDLASHLGI--RGSPRDSDAESD-----------------------AGKKESDDDSRP 768

Query: 584 FERDEERSANGGSESDGEENI 604
             R  E    G S+S+   NI
Sbjct: 769 PHRKREGPIGGESDSEEVRNI 789



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 129/574 (22%), Positives = 206/574 (35%), Gaps = 111/574 (19%)

Query: 10  EKEAAGTTAAAG--TGGATEQPPRHREHKKHK--------------HRSGGSGGSGGERR 53
           E   A T AA G    G  E+PPR  E    K                 GG+GG  GER 
Sbjct: 125 EAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEPPPLGEGGGGGGEGGGAGGGSGERE 184

Query: 54  KRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKRE---KRDDGYEAAASSKT 110
             + +    RG   +G  A+ R  + G   S +  S    K      R+ G   A     
Sbjct: 185 GGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSPSSSSAGKTPGTGSRNSGSGVAGGGSG 244

Query: 111 SSGD-------ASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQ 163
             G         S L      K RA       +++A K   G+     ++ V  P A   
Sbjct: 245 GGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHA-KNGGGSSSR--SSPVSGPPA--- 298

Query: 164 REELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERS----RQLQKEKDLAEK 219
              + E LA A    +     G  ++           AA    S    +QLQ+++++ E+
Sbjct: 299 ---VCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAAAPPSSQPHPQQLQEQEEMQEE 355

Query: 220 RAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDK 279
             KL EE       +  ++ E  + R ++   R           D+F E        +D 
Sbjct: 356 MEKLREE-------NETLKNEIDELRTEMDEMR-----------DTFFE--------EDA 389

Query: 280 GVLQEEEDVLVNVNLVDKERAEKN-----VELRKKKPDYLPYAEDESVDDLAQQKPRSIL 334
             LQE    L        ERA KN       LRK +   L YA+   +D         +L
Sbjct: 390 CQLQEMRHEL--------ERANKNCRILQYRLRKAERKRLRYAQTGEIDG-------ELL 434

Query: 335 SKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPE 394
              +++L+  +  S RL         +    E+   KLR Q   +      L +E    +
Sbjct: 435 RSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMK 494

Query: 395 EMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEK 454
           E+   ++  + + K  KK ++     D+     D      F        R++++++++EK
Sbjct: 495 ELSLKRRGSKDLPKSEKKAQQTPTEEDN----EDLKCQLQFVKEEAALMRKKMAKIDKEK 550

Query: 455 EPVPQPLPSDDTRVENMDIS-DEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQ 513
           +     L    +   ++D    + E G PP          EAEL+L        RLR ++
Sbjct: 551 DRFEHELQKYRSFYGDLDSPLPKGEAGGPP-------STREAELKL--------RLRLVE 595

Query: 514 QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPER 547
             ++    G K+VE    LE   RG + + D  R
Sbjct: 596 --EEANILGRKIVE----LEVENRGLKAELDDLR 623


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 110/457 (24%), Positives = 186/457 (40%), Gaps = 87/457 (19%)

Query: 51   ERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKT 110
            E R+R+   G ER       EA A S T   E  Q    E   +        EA  SSK 
Sbjct: 1494 EERERAEAEGRER-------EARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1546

Query: 111  SSGD-------ASSLSIEETNKLRA---------------KLGLKPLEVNAIKK------ 142
              G        A  ++ +  N LRA               KL L+ + V A+K       
Sbjct: 1547 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE-VTVQALKTQHERDL 1605

Query: 143  ----EAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLD 198
                EAG +     A  +    + + EE +++  A   ++ L  +L ++K          
Sbjct: 1606 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK---------- 1655

Query: 199  DTAAWIERSRQLQKE--KDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQG 256
               A +  + Q ++E  K L + +A++ E   +     T  EE F Q R+   S + L+G
Sbjct: 1656 ---AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE---SEKRLKG 1709

Query: 257  LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLV----NVNLVDKERAEKNVELRKKKPD 312
            L  E      R  E +  + + +   Q++ D +     N NL      E+  +L  +   
Sbjct: 1710 LEAE----VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1765

Query: 313  YLPYAEDE-SVDDLAQQKPRSILSKYDE---ELEGERPHSFRLEQGGTADGLRERELEEI 368
                 E+E S  +L   + R +L + +    EL  ER  S + E G       ER+++E+
Sbjct: 1766 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ---LERQIQEL 1822

Query: 369  RAKLR-----LQAQSLSTVGPRLASEYLTPEEMVTFKKTKRR------VKKIRKKEKEVV 417
            R +L       +A+   T+   L S+    EE +  ++T+ R      V++  K+ KEVV
Sbjct: 1823 RGRLGEEDAGARARHKMTIAA-LESKLAQAEEQLE-QETRERILSGKLVRRAEKRLKEVV 1880

Query: 418  VRADDLLPLGDQTQDGDFGSRLRGRG-RRRVSEVEEE 453
            ++ ++   + DQ +D      LR +  +R++ E EEE
Sbjct: 1881 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1917



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 134/657 (20%), Positives = 255/657 (38%), Gaps = 70/657 (10%)

Query: 81   RERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAI 140
            +++S  E  E + +  + ++     A    +  +  + + E   +L A+     L V+ +
Sbjct: 893  QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL 952

Query: 141  KKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDT 200
            +   G +EE           L+Q  +  E    A+E      +L K+ T  +   + +D 
Sbjct: 953  EARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDL 1012

Query: 201  AAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVE 260
                +++ +L KE+       KLLE+   EF      EEE   + + L   R     T+ 
Sbjct: 1013 LLLEDQNSKLSKER-------KLLEDRLAEFSSQAAEEEE---KVKSLNKLRLKYEATIA 1062

Query: 261  HAIDSFREGETMILTL-KDKGVLQEEEDVLVNVNLVDKERAEK-NVELRKKKPDY---LP 315
               D  R+ E     L K K  L  E   L    +  ++RAE+   +L +K+ +    L 
Sbjct: 1063 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1122

Query: 316  YAEDESVDDL----AQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAK 371
             AEDE         + ++ ++ L++  E+LE ER    + E+     G    ELE +R +
Sbjct: 1123 RAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG---EELEALRGE 1179

Query: 372  LRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQ 431
            L     +L +   +        +E+   KKT     +I +   +  +R      LG+  +
Sbjct: 1180 LE---DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQ-ELRQRHGQALGELAE 1235

Query: 432  DGDFGSRLRGRGRR-------RVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPP 484
              +   R +G   +        VSE+  E   +       + R   +++  +E  G    
Sbjct: 1236 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD 1295

Query: 485  G------SPQVLEEDEAELE-----LQKQLEKGRRL-RQLQQLQ-QLRDSGEKVVEIVK- 530
            G      + + L+  +AELE     L +   K  RL ++L   + QL D+ E + E  + 
Sbjct: 1296 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1355

Query: 531  --KLESRQRGWEED-----EDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMD 583
               L SR R  E +     E  E + A    A  E      ++  +     R ++EE   
Sbjct: 1356 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW----RRRQEEEAGA 1411

Query: 584  FERDEERSANGGSESDG-EENIGWSTVNLD-----EEKQQQDFSASSTTILDEEPIVN-- 635
             E  EE       E++   + +   T  +D       + QQ+   ++  +  +  +V+  
Sbjct: 1412 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1471

Query: 636  --RGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREE 690
              +      LL + K  +   V++  R +A  +   +    +    A++++   REE
Sbjct: 1472 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAREE 1526


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 110/457 (24%), Positives = 186/457 (40%), Gaps = 87/457 (19%)

Query: 51   ERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKT 110
            E R+R+   G ER       EA A S T   E  Q    E   +        EA  SSK 
Sbjct: 1486 EERERAEAEGRER-------EARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1538

Query: 111  SSGD-------ASSLSIEETNKLRA---------------KLGLKPLEVNAIKK------ 142
              G        A  ++ +  N LRA               KL L+ + V A+K       
Sbjct: 1539 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE-VTVQALKTQHERDL 1597

Query: 143  ----EAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLD 198
                EAG +     A  +    + + EE +++  A   ++ L  +L ++K          
Sbjct: 1598 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK---------- 1647

Query: 199  DTAAWIERSRQLQKE--KDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQG 256
               A +  + Q ++E  K L + +A++ E   +     T  EE F Q R+   S + L+G
Sbjct: 1648 ---AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE---SEKRLKG 1701

Query: 257  LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLV----NVNLVDKERAEKNVELRKKKPD 312
            L  E      R  E +  + + +   Q++ D +     N NL      E+  +L  +   
Sbjct: 1702 LEAE----VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1757

Query: 313  YLPYAEDE-SVDDLAQQKPRSILSKYDE---ELEGERPHSFRLEQGGTADGLRERELEEI 368
                 E+E S  +L   + R +L + +    EL  ER  S + E G       ER+++E+
Sbjct: 1758 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ---LERQIQEL 1814

Query: 369  RAKLR-----LQAQSLSTVGPRLASEYLTPEEMVTFKKTKRR------VKKIRKKEKEVV 417
            R +L       +A+   T+   L S+    EE +  ++T+ R      V++  K+ KEVV
Sbjct: 1815 RGRLGEEDAGARARHKMTIAA-LESKLAQAEEQLE-QETRERILSGKLVRRAEKRLKEVV 1872

Query: 418  VRADDLLPLGDQTQDGDFGSRLRGRG-RRRVSEVEEE 453
            ++ ++   + DQ +D      LR +  +R++ E EEE
Sbjct: 1873 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1909



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 134/657 (20%), Positives = 255/657 (38%), Gaps = 70/657 (10%)

Query: 81   RERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAI 140
            +++S  E  E + +  + ++     A    +  +  + + E   +L A+     L V+ +
Sbjct: 885  QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL 944

Query: 141  KKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDT 200
            +   G +EE           L+Q  +  E    A+E      +L K+ T  +   + +D 
Sbjct: 945  EARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDL 1004

Query: 201  AAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVE 260
                +++ +L KE+       KLLE+   EF      EEE   + + L   R     T+ 
Sbjct: 1005 LLLEDQNSKLSKER-------KLLEDRLAEFSSQAAEEEE---KVKSLNKLRLKYEATIA 1054

Query: 261  HAIDSFREGETMILTL-KDKGVLQEEEDVLVNVNLVDKERAEK-NVELRKKKPDY---LP 315
               D  R+ E     L K K  L  E   L    +  ++RAE+   +L +K+ +    L 
Sbjct: 1055 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1114

Query: 316  YAEDESVDDL----AQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAK 371
             AEDE         + ++ ++ L++  E+LE ER    + E+     G    ELE +R +
Sbjct: 1115 RAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG---EELEALRGE 1171

Query: 372  LRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQ 431
            L     +L +   +        +E+   KKT     +I +   +  +R      LG+  +
Sbjct: 1172 LE---DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQ-ELRQRHGQALGELAE 1227

Query: 432  DGDFGSRLRGRGRR-------RVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPP 484
              +   R +G   +        VSE+  E   +       + R   +++  +E  G    
Sbjct: 1228 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD 1287

Query: 485  G------SPQVLEEDEAELE-----LQKQLEKGRRL-RQLQQLQ-QLRDSGEKVVEIVK- 530
            G      + + L+  +AELE     L +   K  RL ++L   + QL D+ E + E  + 
Sbjct: 1288 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1347

Query: 531  --KLESRQRGWEED-----EDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMD 583
               L SR R  E +     E  E + A    A  E      ++  +     R ++EE   
Sbjct: 1348 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW----RRRQEEEAGA 1403

Query: 584  FERDEERSANGGSESDG-EENIGWSTVNLD-----EEKQQQDFSASSTTILDEEPIVN-- 635
             E  EE       E++   + +   T  +D       + QQ+   ++  +  +  +V+  
Sbjct: 1404 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1463

Query: 636  --RGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREE 690
              +      LL + K  +   V++  R +A  +   +    +    A++++   REE
Sbjct: 1464 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAREE 1518


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 110/457 (24%), Positives = 186/457 (40%), Gaps = 87/457 (19%)

Query: 51   ERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKT 110
            E R+R+   G ER       EA A S T   E  Q    E   +        EA  SSK 
Sbjct: 1527 EERERAEAEGRER-------EARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1579

Query: 111  SSGD-------ASSLSIEETNKLRA---------------KLGLKPLEVNAIKK------ 142
              G        A  ++ +  N LRA               KL L+ + V A+K       
Sbjct: 1580 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE-VTVQALKTQHERDL 1638

Query: 143  ----EAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLD 198
                EAG +     A  +    + + EE +++  A   ++ L  +L ++K          
Sbjct: 1639 QGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK---------- 1688

Query: 199  DTAAWIERSRQLQKE--KDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQG 256
               A +  + Q ++E  K L + +A++ E   +     T  EE F Q R+   S + L+G
Sbjct: 1689 ---AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE---SEKRLKG 1742

Query: 257  LTVEHAIDSFREGETMILTLKDKGVLQEEEDVLV----NVNLVDKERAEKNVELRKKKPD 312
            L  E      R  E +  + + +   Q++ D +     N NL      E+  +L  +   
Sbjct: 1743 LEAE----VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1798

Query: 313  YLPYAEDE-SVDDLAQQKPRSILSKYDE---ELEGERPHSFRLEQGGTADGLRERELEEI 368
                 E+E S  +L   + R +L + +    EL  ER  S + E G       ER+++E+
Sbjct: 1799 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ---LERQIQEL 1855

Query: 369  RAKLR-----LQAQSLSTVGPRLASEYLTPEEMVTFKKTKRR------VKKIRKKEKEVV 417
            R +L       +A+   T+   L S+    EE +  ++T+ R      V++  K+ KEVV
Sbjct: 1856 RGRLGEEDAGARARHKMTIAA-LESKLAQAEEQLE-QETRERILSGKLVRRAEKRLKEVV 1913

Query: 418  VRADDLLPLGDQTQDGDFGSRLRGRG-RRRVSEVEEE 453
            ++ ++   + DQ +D      LR +  +R++ E EEE
Sbjct: 1914 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1950



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 134/657 (20%), Positives = 255/657 (38%), Gaps = 70/657 (10%)

Query: 81   RERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAI 140
            +++S  E  E + +  + ++     A    +  +  + + E   +L A+     L V+ +
Sbjct: 926  QQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSEL 985

Query: 141  KKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDT 200
            +   G +EE           L+Q  +  E    A+E      +L K+ T  +   + +D 
Sbjct: 986  EARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDL 1045

Query: 201  AAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVE 260
                +++ +L KE+       KLLE+   EF      EEE   + + L   R     T+ 
Sbjct: 1046 LLLEDQNSKLSKER-------KLLEDRLAEFSSQAAEEEE---KVKSLNKLRLKYEATIA 1095

Query: 261  HAIDSFREGETMILTL-KDKGVLQEEEDVLVNVNLVDKERAEK-NVELRKKKPDY---LP 315
               D  R+ E     L K K  L  E   L    +  ++RAE+   +L +K+ +    L 
Sbjct: 1096 DMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALA 1155

Query: 316  YAEDESVDDL----AQQKPRSILSKYDEELEGERPHSFRLEQGGTADGLRERELEEIRAK 371
             AEDE         + ++ ++ L++  E+LE ER    + E+     G    ELE +R +
Sbjct: 1156 RAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG---EELEALRGE 1212

Query: 372  LRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGDQTQ 431
            L     +L +   +        +E+   KKT     +I +   +  +R      LG+  +
Sbjct: 1213 LE---DTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQ-ELRQRHGQALGELAE 1268

Query: 432  DGDFGSRLRGRGRR-------RVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPP 484
              +   R +G   +        VSE+  E   +       + R   +++  +E  G    
Sbjct: 1269 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD 1328

Query: 485  G------SPQVLEEDEAELE-----LQKQLEKGRRL-RQLQQLQ-QLRDSGEKVVEIVK- 530
            G      + + L+  +AELE     L +   K  RL ++L   + QL D+ E + E  + 
Sbjct: 1329 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1388

Query: 531  --KLESRQRGWEED-----EDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMD 583
               L SR R  E +     E  E + A    A  E      ++  +     R ++EE   
Sbjct: 1389 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW----RRRQEEEAGA 1444

Query: 584  FERDEERSANGGSESDG-EENIGWSTVNLD-----EEKQQQDFSASSTTILDEEPIVN-- 635
             E  EE       E++   + +   T  +D       + QQ+   ++  +  +  +V+  
Sbjct: 1445 LEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTL 1504

Query: 636  --RGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRREE 690
              +      LL + K  +   V++  R +A  +   +    +    A++++   REE
Sbjct: 1505 EKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL--TRALEEEQEAREE 1559


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 114/476 (23%), Positives = 200/476 (42%), Gaps = 85/476 (17%)

Query: 154 DVINPMALRQREELREKLAAA---KEKRLLNQK-LGKIKTLGEDDPWLDDTAAWIERSRQ 209
           +VI P  + Q +E + +LA     K  R  +Q+ L + +T+ E    L+        S  
Sbjct: 535 EVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLE--------SLN 586

Query: 210 LQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREG 269
           +Q+EK+  E+R   L+++ +        E +  ++ + L     ++  TV   ++  ++ 
Sbjct: 587 IQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKT 646

Query: 270 ETMILTLKDKGVLQEEE---DVLV--NVNLVDKERAEKNVELR--KKKPDYLPYA---ED 319
           E      KD  +   EE   D ++   V  ++KE+ E    L+  +KK DY   A   E+
Sbjct: 647 ELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEE 706

Query: 320 ESVDDLAQQKPRSILSKYDEELEGERPHSFRLEQGGTADG-------LRERELEEIRAKL 372
             +   A ++ R       E+ E ER  + +LE+    +        L +R+L  +R K 
Sbjct: 707 IPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKA 766

Query: 373 RLQA---QSLSTVGPRLASE-YLTPEEMVTFKKTKRRVKKIRKKEKEVVVRADDLLPLGD 428
             Q+   + L     RLA E +   EE    +K +RR+   R+KE+E   RA++ + L +
Sbjct: 767 ARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQM-LKE 825

Query: 429 QTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQ 488
           + +      R R    +R  E+ E +E V +                             
Sbjct: 826 REE------RERAERAKREEELREYQERVKK----------------------------- 850

Query: 489 VLEEDEAELELQKQLEKGRRLRQLQQLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERK 548
            LEE E + + Q++LE   R R+ ++ ++L DS       + + +SR  G  + E   RK
Sbjct: 851 -LEEVERK-KRQRELEIEERERRREEERRLGDSS------LSRKDSRW-GDRDSEGTWRK 901

Query: 549 GAIVFNATSEFCRTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENI 604
           G     A SE+ R     P        E ++E     RDEER    G + D E ++
Sbjct: 902 GP---EADSEWRRG----PPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSL 950



 Score = 36.6 bits (83), Expect = 0.095
 Identities = 83/432 (19%), Positives = 168/432 (38%), Gaps = 65/432 (15%)

Query: 53  RKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSS 112
           ++   +R  E    R+  E   R     RE+ +      ++K++   +  E    ++  +
Sbjct: 591 KEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGA 650

Query: 113 GDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLA 172
                + IE+  +L     +   +V  ++KE   K+E           L++R + +EK  
Sbjct: 651 KAFKDIDIEDLEELDPDF-IMAKQVEQLEKE---KKE-----------LQERLKNQEKKI 695

Query: 173 AAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIER------SRQLQKEKDLAEKR--AKLL 224
              E+    +++  IK+  E+   + D   W ++      + QL++EK L  K   +++L
Sbjct: 696 DYFERAKRLEEIPLIKSAYEEQR-IKDMDLWEQQEEERITTMQLEREKALEHKNRMSRML 754

Query: 225 EEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQE 284
           E+ D       L        RQ +Y          E  +  F E             L E
Sbjct: 755 EDRD-------LFVMRLKAARQSVY----------EEKLKQFEER------------LAE 785

Query: 285 EEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEELEGE 344
           E    +      ++   +    R+K+ +    AE++ + +  +++ R+  +K +EEL   
Sbjct: 786 ERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKE-REERERAERAKREEELREY 844

Query: 345 RPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKTKR 404
           +    +LE+       RE E+EE   +   + +   +   R  S +   +   T++K   
Sbjct: 845 QERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPE 904

Query: 405 RVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQPLPSD 464
              + R+   E   R         + +D D   R      RR+ + +E++EP  +P   D
Sbjct: 905 ADSEWRRGPPEKEWRR-------GEGRDEDRSHRRDEERPRRLGD-DEDREPSLRP---D 953

Query: 465 DTRVENMDISDE 476
           D RV    + D+
Sbjct: 954 DDRVPRRGMDDD 965


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 152/779 (19%), Positives = 303/779 (38%), Gaps = 85/779 (10%)

Query: 52   RRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRD-DGYEAAASSKT 110
            +R  S+ER G++  GR  A+ +   + HG   + + P +  +  +  + +G + +   + 
Sbjct: 427  QRPLSQERRGKQSVGRTFAKLQG--AAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRA 484

Query: 111  SSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTA------DVINPMALRQR 164
             S  A S   EE     A L L+     A   ++G K+  V            P  L+ +
Sbjct: 485  PSLGAQSKKEEEVKTATATLMLQN-RATATSPDSGAKKISVKTFPSASNTQATPDLLKGQ 543

Query: 165  EELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLL 224
            +EL ++      K++L   L +    G  D   +D A   + +   +K + L  + A   
Sbjct: 544  QELTQQTNEETAKQILYNYLKE----GSTD---NDDATKRKVNLVFEKIQTLKSRAAGSA 596

Query: 225  EEMDQEFGVSTLVEEEFGQRRQDLYSARDLQG---LTVEHAIDSFREGETMILTLKDKGV 281
            +  +Q    ++ V++   Q+ +      +LQ    L V++  +   E E M   L++   
Sbjct: 597  QGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEE--- 653

Query: 282  LQEEEDVLVNVNLVDKERAEKNV-ELRKKKPDYLPYAEDESVDDLAQQKPRSILSKYDEE 340
            L+ + +  V  N   ++R E++  ELRK   +      +        +  +  LS+  +E
Sbjct: 654  LRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713

Query: 341  LEGERPHSFRLEQGGTADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFK 400
            L+  +    R E+G   + L       ++AK  LQ   ++             E+    +
Sbjct: 714  LDSAKRSEDR-EKGALIEEL-------LQAKQDLQDLLIAK-----------EEQEDLLR 754

Query: 401  KTKRRVKKIRKKEKEVVVRADDLLPLGDQTQDGDFGSRLRGRGRRRVSEVEEEKEPVPQP 460
            K +R +  ++   KE V   D  +    +  D               +E++  +E V + 
Sbjct: 755  KRERELTALKGALKEEVSSHDQEMDKLKEQYD---------------AELQALRESVEEA 799

Query: 461  LPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQ-QLQQLR 519
              + +      + S++++ G       ++L+E+  +L+ + + E  RR+ QLQ Q++ L+
Sbjct: 800  TKNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSE-ELERRVAQLQRQIEDLK 856

Query: 520  DSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGNREEQE 579
                K  E +KK E   R  EE     RK      +         E     L+   +EQ+
Sbjct: 857  GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQK 916

Query: 580  ELMDFERDEERSANGGSESDGE-ENIGWSTVNLDE--EKQQQDFSASSTTI-------LD 629
            +L +  ++E            E EN  W      E  +K+  D   +S T        LD
Sbjct: 917  QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976

Query: 630  EEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIEDKMAIDDKYSRRE 689
            E    NR   A +     +  LE    ++  +K  ++         + + A D+  ++R+
Sbjct: 977  EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ 1036

Query: 690  EYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKE-AFRQLSHRFHGKGSGK-------M 741
                  +D +    Y+ + K    D+  R +   E    QL      + +          
Sbjct: 1037 LLEQTLKDLE----YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092

Query: 742  KTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKSMNANTITK 800
            ++  +M++L  E L ++ +  D     ++ L+ + K  K+  I L GS +S     + +
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKIS-LERQNKDLKSRIIHLEGSYRSSKEGLVVQ 1150


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/193 (25%), Positives = 75/193 (38%), Gaps = 19/193 (9%)

Query: 27  EQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGER--GSGRRGAEAEARSSTHGRERS 84
           E+  R RE +K + R  G     GER+K  RER   R     + G E E R     +ER 
Sbjct: 65  EREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERG 124

Query: 85  QA--EPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKK 142
           +   E  ER  K E++ +  +     K           EE  K R +   K  E    +K
Sbjct: 125 RTSKEGKERERKEERKREERKERERKK-----------EEREKERERKERKKRE----RK 169

Query: 143 EAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAA 202
           + G KEE            R+R     K    +++R   +K  K K   + +   D    
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTN 229

Query: 203 WIERSRQLQKEKD 215
           W E+ R  ++ K+
Sbjct: 230 WREKERGKRERKE 242



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 40/151 (26%), Positives = 57/151 (37%), Gaps = 17/151 (11%)

Query: 5   KKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKR--SRERG-- 60
           K+ RG+KE  G           E+    RE KK +       G   E+RK+   +ERG  
Sbjct: 78  KRERGKKEKKG-----------ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126

Query: 61  GERGSGRRGAEAEARSSTHGRERSQAEPSERRVKRE--KRDDGYEAAASSKTSSGDASSL 118
            + G  R   E   R     RER + E  + R ++E  KR+         +    +    
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186

Query: 119 SIEETNKLRAKLGLKPLEVNAIKKEAGTKEE 149
              E N+   K   +  E    KKE   KEE
Sbjct: 187 KKRERNRKERKKERERKERRERKKERKKKEE 217



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 43/195 (22%), Positives = 78/195 (40%), Gaps = 19/195 (9%)

Query: 52  RRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTS 111
           R++  +ER  ER   RR  E   R     R+R        R K+EK+ +  +     K  
Sbjct: 48  RKEGKKERESERKKERREREKRKREREKERKR-------ERGKKEKKGERKKEERERKKR 100

Query: 112 SGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKL 171
             +  +   EE  K + K   +    +   KE   KEE    +        ++E  R+K 
Sbjct: 101 RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREE--------RKERERKKE 152

Query: 172 AAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEF 231
              KE+    +K  + K +GE +    +     ER  + ++E++  E++ +   +  +E 
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEK----ERKERKKRERNRKERKKERERKERRER 208

Query: 232 GVSTLVEEEFGQRRQ 246
                 +EE  + RQ
Sbjct: 209 KKERKKKEERKKERQ 223



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 31/168 (18%), Positives = 68/168 (40%), Gaps = 15/168 (8%)

Query: 455 EPVPQPLPSDDTRVENMDISDEEEGGAPPPGSPQVLEEDEAELELQKQLEKGRRLRQLQQ 514
           +P  QP    + R    +I   +EG            + E E E +K+  +  + ++ ++
Sbjct: 27  KPCTQPGWQSEIREREREIETRKEG------------KKERESERKKERREREKRKRERE 74

Query: 515 LQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAGN 574
            ++ R+ G+K  +  +K E R+R     E   ++G        +  +  G     G    
Sbjct: 75  KERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134

Query: 575 REEQ---EELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQQQD 619
           R+E+   EE  + ER +E         + ++         +EE+++++
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.128    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,404,356
Number of Sequences: 37866
Number of extensions: 1739125
Number of successful extensions: 14330
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 819
Number of HSP's that attempted gapping in prelim test: 10266
Number of HSP's gapped (non-prelim): 3608
length of query: 800
length of database: 18,247,518
effective HSP length: 110
effective length of query: 690
effective length of database: 14,082,258
effective search space: 9716758020
effective search space used: 9716758020
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.