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Search of human proteins with 237858679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
(1174 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 2412 0.0
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 2402 0.0
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 2397 0.0
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 1645 0.0
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 1233 0.0
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 1229 0.0
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 1226 0.0
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 1032 0.0
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 829 0.0
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 732 0.0
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 724 0.0
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 724 0.0
gi|28373129 contactin 5 isoform short [Homo sapiens] 369 e-102
gi|7657359 contactin 5 isoform long [Homo sapiens] 368 e-101
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 365 e-100
gi|4827022 contactin 2 precursor [Homo sapiens] 365 e-100
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 365 e-100
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 365 e-100
gi|75709184 contactin 3 [Homo sapiens] 363 e-100
gi|7657361 contactin 6 [Homo sapiens] 319 9e-87
gi|119220552 sidekick 1 [Homo sapiens] 265 2e-70
gi|28373126 contactin 4 isoform c precursor [Homo sapiens] 264 3e-70
gi|222352127 sidekick 2 [Homo sapiens] 239 9e-63
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 217 5e-56
gi|157311649 neogenin homolog 1 [Homo sapiens] 214 4e-55
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 209 2e-53
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 199 1e-50
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 189 2e-47
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 189 2e-47
gi|19743806 roundabout 1 isoform b [Homo sapiens] 186 1e-46
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 2412 bits (6252), Expect = 0.0
Identities = 1174/1174 (100%), Positives = 1174/1174 (100%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
Query: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
Query: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
Query: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
Query: 601 YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ 660
YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ
Sbjct: 601 YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ 660
Query: 661 FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG 720
FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG
Sbjct: 661 FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG 720
Query: 721 APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS 780
APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS
Sbjct: 721 APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS 780
Query: 781 RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL 840
RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL
Sbjct: 781 RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL 840
Query: 841 QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY 900
QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY
Sbjct: 841 QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY 900
Query: 901 KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG 960
KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG
Sbjct: 901 KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG 960
Query: 961 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP
Sbjct: 961 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
Query: 1021 APPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD 1080
APPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD
Sbjct: 1021 APPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD 1080
Query: 1081 VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG 1140
VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG
Sbjct: 1081 VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG 1140
Query: 1141 SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1174
SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Sbjct: 1141 SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1174
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 2402 bits (6226), Expect = 0.0
Identities = 1174/1189 (98%), Positives = 1174/1189 (98%), Gaps = 15/1189 (1%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
Query: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
Query: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
Query: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
Query: 601 YTCVASTELDQDLAKAYLTVL---------------GRPDRPRDLELTDLAERSVRLTWI 645
YTCVASTELDQDLAKAYLTVL GRPDRPRDLELTDLAERSVRLTWI
Sbjct: 601 YTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWI 660
Query: 646 PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVG 705
PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVG
Sbjct: 661 PGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVG 720
Query: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765
SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR
Sbjct: 721 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 780
Query: 766 RETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAP 825
RETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAP
Sbjct: 781 RETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAP 840
Query: 826 TEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGD 885
TEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGD
Sbjct: 841 TEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGD 900
Query: 886 RLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETIN 945
RLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETIN
Sbjct: 901 RLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETIN 960
Query: 946 LEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSA 1005
LEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSA
Sbjct: 961 LEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSA 1020
Query: 1006 RTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFI 1065
RTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFI
Sbjct: 1021 RTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFI 1080
Query: 1066 KRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSL 1125
KRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSL
Sbjct: 1081 KRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSL 1140
Query: 1126 VDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1174
VDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Sbjct: 1141 VDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1189
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 2397 bits (6211), Expect = 0.0
Identities = 1169/1174 (99%), Positives = 1169/1174 (99%), Gaps = 5/1174 (0%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
Query: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
Query: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
Query: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
Query: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
Query: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
Query: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
Query: 601 YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ 660
YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ
Sbjct: 601 YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQ 660
Query: 661 FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG 720
FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG
Sbjct: 661 FEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSG 720
Query: 721 APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS 780
APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS
Sbjct: 721 APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS 780
Query: 781 RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL 840
RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL
Sbjct: 781 RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISL 840
Query: 841 QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY 900
QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY
Sbjct: 841 QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNY 900
Query: 901 KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG 960
KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG
Sbjct: 901 KLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIG 960
Query: 961 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP
Sbjct: 961 YTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
Query: 1021 APPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD 1080
APPNE AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD
Sbjct: 1021 APPNE-----AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKD 1075
Query: 1081 VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG 1140
VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG
Sbjct: 1076 VPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDG 1135
Query: 1141 SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1174
SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Sbjct: 1136 SFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1169
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 1645 bits (4260), Expect = 0.0
Identities = 829/953 (86%), Positives = 848/953 (88%), Gaps = 49/953 (5%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
Query: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236
Query: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK
Sbjct: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283
Query: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
Sbjct: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
Query: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534
WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
Sbjct: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523
Query: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA
Sbjct: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583
Query: 595 ERDQGSYTCVASTELDQDLAKAYLTVL---------------GRPDRPRDLELTDLAERS 639
ERDQGSYTCVASTELDQDLAKAYLTVL GRPDRPRDLELTDLAERS
Sbjct: 584 ERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERS 643
Query: 640 VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI 699
VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI
Sbjct: 644 VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVI 703
Query: 700 AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY 759
AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY
Sbjct: 704 AINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY 763
Query: 760 IVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGED 819
IVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGED
Sbjct: 764 IVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGED 823
Query: 820 YPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ 879
P +AP +VR N I+L+W+ + + G + Y Y + N K+
Sbjct: 824 LP-SAPRRFRVRQPNLETINLEWD--HPEHPNGIMIGYTLKY-----VAFNGTKVGKQIV 875
Query: 880 ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP--EGVPSA 930
+F ++ + V R P S Y+ + G G + T+E P E P+A
Sbjct: 876 ENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG-EAVTEESPAPPNEATPTA 927
Score = 302 bits (773), Expect = 1e-81
Identities = 162/236 (68%), Positives = 176/236 (74%), Gaps = 15/236 (6%)
Query: 939 PNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSR 998
PN + N+ W H P + ++Y+ N TK + P +Q TD
Sbjct: 1020 PNSKWANITWKHNFGPG---TDFVVEYIDSNHTKKTVPVKAQAQP------IQLTDLYPG 1070
Query: 999 YRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLI 1058
+TL ++ G + T + + AYTNNQADIATQGWFIGLMCAIALLVLI
Sbjct: 1071 MTYTLRVYSRDNEGISSTVIT------FMTSTAYTNNQADIATQGWFIGLMCAIALLVLI 1124
Query: 1059 LLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQ 1118
LLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQ
Sbjct: 1125 LLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQ 1184
Query: 1119 QESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1174
QESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Sbjct: 1185 QESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA 1240
Score = 300 bits (769), Expect = 4e-81
Identities = 285/952 (29%), Positives = 421/952 (44%), Gaps = 102/952 (10%)
Query: 126 IRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS-MEPITQDKRVS 184
I+ ++++ P K++ +V + ++C G P+P W +S I +D RVS
Sbjct: 33 IQNELTQPPTITKQSAKDHIVDPRDNILIECEAK-GNPAPSFHWTRNSRFFNIAKDPRVS 91
Query: 185 -QGHNGDL---YFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
+ +G L + S ++ + +Y C AR F + N L+V
Sbjct: 92 MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALS--NRIRLQV------------- 136
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGD-L 298
+ S ++P+ +V G L L+C G+P+P I W + +
Sbjct: 137 -------------SKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPI 183
Query: 299 PSDKAKFENFNKALRITNVSEED-SGEYFCLASNKMGSIRHTI----------------S 341
DK + N L +NV +D +Y C N HTI +
Sbjct: 184 TQDKRVSQGHNGDLYFSNVMLQDMQTDYSC---NARFHFTHTIQQKNPFTLKVLTTRGVA 240
Query: 342 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 401
R + Y + ++ G D L C A+G P P + W G L P+ +
Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL----PSDKAKFEN 296
Query: 402 DTIIFRDTQISSR--AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 459
R T +S Y C SN+ G + V V P + P+N ++
Sbjct: 297 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP--GEDG 354
Query: 460 RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI-KMIRKEDQGIYTCVATNIL 518
RL C G+P PT++W NG+ N + G I + + + +Y C +N
Sbjct: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEH 414
Query: 519 GKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDDEPLY 576
G + V D P +Q+ R +L+C P T+ W K+ +
Sbjct: 415 GYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP--TLRWFKNGQGSN 472
Query: 577 I--GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTD 634
+ GN E+ SL I + + DQG YTCVA+ L + + L V P R +
Sbjct: 473 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD-PTRIYRMPEDQ 531
Query: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNY 694
+A R + + + P V + +D + + K S+ + ++
Sbjct: 532 VARRGTTVQ-LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLT--IFGVAERDQG 588
Query: 695 QFRVIAINEVGS----------SHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITW 744
+ +A E+ + + P+ R P D++ + ++ +TW
Sbjct: 589 SYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTW 648
Query: 745 TPMNATSAFGPNLRYIVKWRRRETREA-WNNVTVW-GS-RYVVGQTPVYVPYEIRVQAEN 801
P +A ++ P Y+V++ + + W++ + + GS V + YV Y+ RV A N
Sbjct: 649 IPGDANNS--PITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAIN 706
Query: 802 DFGKGPE--PESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRA 859
+ G P SG P + P +VK + + W + + + G Y
Sbjct: 707 EVGSSHPSLPSERYRTSGAP-PESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIV 765
Query: 860 YYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETK 919
+ R + + W + G R VV + Y Y++ + N G GP E+
Sbjct: 766 KWRRRET--REAW-----NNVTVWGSRY--VVGQTPVYVPYEIRVQAENDFGKGPEPESV 816
Query: 920 EFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE 979
+ E +PSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE
Sbjct: 817 IGYSGEDLPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE 876
Query: 980 NFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAA 1031
NFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAA
Sbjct: 877 NFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAA 928
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 1233 bits (3189), Expect = 0.0
Identities = 604/622 (97%), Positives = 604/622 (97%), Gaps = 17/622 (2%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
Query: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61 GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240
KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---------- 230
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 231 -------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
Query: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
Query: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
Query: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480
TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 404 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 463
Query: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540
GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 464 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 523
Query: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600
DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 524 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 583
Query: 601 YTCVASTELDQDLAKAYLTVLG 622
YTCVASTELDQDLAKAYLTVLG
Sbjct: 584 YTCVASTELDQDLAKAYLTVLG 605
Score = 98.2 bits (243), Expect = 4e-20
Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)
Query: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318
++L+EC A G P P W + ++F N K R++
Sbjct: 52 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103
Query: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374
EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G
Sbjct: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 162
Query: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428
P P + WM + EP+ + N ++ ++ +D Q Y CN H
Sbjct: 163 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 218
Query: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479
N F V + P + P+ ++ L +C G P P + W+K G
Sbjct: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 278
Query: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539
D + + N +L I + +ED G Y C+A+N +G + + + VK P
Sbjct: 279 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 337
Query: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596
++ + G +L CR +P K TV W+ + EPL + D++
Sbjct: 338 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 395
Query: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626
+ Y C S E LA A+++VL P R
Sbjct: 396 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 1229 bits (3179), Expect = 0.0
Identities = 607/1167 (52%), Positives = 815/1167 (69%), Gaps = 14/1167 (1%)
Query: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSR 74
+L L + A+E+P+DL QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF WTRN
Sbjct: 20 ILFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGT 79
Query: 75 FFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP 134
F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I ++ S+SP
Sbjct: 80 HFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSP 139
Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
LW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG NGDLYFS
Sbjct: 140 LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199
Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPD--MYSARGVAE 252
NV+ +D + DY C ARF+ T TIQQK P ++KV++ ND+ N D Y A+ E
Sbjct: 200 NVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRE 259
Query: 253 RTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL 312
R P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++NF K L
Sbjct: 260 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTL 319
Query: 313 RITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 372
+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG L+CRAN
Sbjct: 320 QIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRAN 379
Query: 373 GNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANA 432
GNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+GYLLANA
Sbjct: 380 GNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANA 439
Query: 433 FVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY 492
FV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L Y ++
Sbjct: 440 FVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH 499
Query: 493 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 552
ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +RG+ V
Sbjct: 500 ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSF 559
Query: 553 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 612
EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+T LD
Sbjct: 560 ECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSV 619
Query: 613 LAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWH 672
A A L+V+ P+ P DLELTD ++SV+L+W PGD NNSPIT +++++E+ +PG+WH
Sbjct: 620 SASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH 679
Query: 673 DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKG 732
++ G+ +A L+LSPYVNY FRV+A+N +G S PS SE+Y T + P+ NP V+G
Sbjct: 680 HQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEG 739
Query: 733 EGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWG-SRYVVGQTPVYV 791
G+ +N+ ITW P+N + GP L+Y V WR+++ + W +V V S+Y+V TP +V
Sbjct: 740 LGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFV 799
Query: 792 PYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQ 851
PY I+VQA ND G PEP V+G+SGED P AP V+V V+NST + W+ V +++
Sbjct: 800 PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIR 859
Query: 852 GQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRG 911
G L+ YR YYW+ S K +++ +F G + G++ L P+S+Y L + VVNG+G
Sbjct: 860 GHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKG 919
Query: 912 DGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGT 971
+GP S + F TPEGVPSAP ++ P L+++ LEWD P HPNGI+ YTLKY N T
Sbjct: 920 EGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINST 979
Query: 972 -KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTA 1030
++G + N+T++T++ + +RY+F A+T GSG +TEE+ +E
Sbjct: 980 HELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDE----- 1034
Query: 1031 AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPE--DP 1088
A + Q DIATQGWFIGLMCA+ALL+LILLIVCFI+R++GGKYPV+EK+D PE
Sbjct: 1035 AMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPM 1094
Query: 1089 KEEDGSF-DYSD-EDNKPL-QGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQ 1145
KE+DG+F +YSD ED+KPL +GS+T D T+K+++SDDSLVDYGEG GQFNEDGSFIGQ
Sbjct: 1095 KEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQ 1154
Query: 1146 YTVKKDKEETEGNESSEATSPVNAIYS 1172
Y+ KK+KE EGNESSEA SPVNA+ S
Sbjct: 1155 YSGKKEKEPAEGNESSEAPSPVNAMNS 1181
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 1226 bits (3172), Expect = 0.0
Identities = 604/628 (96%), Positives = 604/628 (96%), Gaps = 23/628 (3%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
Query: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236
Query: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK
Sbjct: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283
Query: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
Sbjct: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
Query: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR
Sbjct: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
Query: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR
Sbjct: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
Query: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534
WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
Sbjct: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523
Query: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA
Sbjct: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583
Query: 595 ERDQGSYTCVASTELDQDLAKAYLTVLG 622
ERDQGSYTCVASTELDQDLAKAYLTVLG
Sbjct: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611
Score = 98.2 bits (243), Expect = 4e-20
Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)
Query: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318
++L+EC A G P P W + ++F N K R++
Sbjct: 58 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109
Query: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374
EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G
Sbjct: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 168
Query: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428
P P + WM + EP+ + N ++ ++ +D Q Y CN H
Sbjct: 169 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 224
Query: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479
N F V + P + P+ ++ L +C G P P + W+K G
Sbjct: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284
Query: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539
D + + N +L I + +ED G Y C+A+N +G + + + VK P
Sbjct: 285 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
Query: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596
++ + G +L CR +P K TV W+ + EPL + D++
Sbjct: 344 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401
Query: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626
+ Y C S E LA A+++VL P R
Sbjct: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 1032 bits (2668), Expect = 0.0
Identities = 507/1032 (49%), Positives = 694/1032 (67%), Gaps = 20/1032 (1%)
Query: 15 LLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 68
+L L + A+E+P+D L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF
Sbjct: 20 ILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 79
Query: 69 WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 128
WTRN F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I +
Sbjct: 80 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 139
Query: 129 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 188
+ S+SPLW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG N
Sbjct: 140 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 199
Query: 189 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPD--MYS 246
GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++ ND+ N D Y
Sbjct: 200 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 259
Query: 247 ARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 306
A+ ER P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++
Sbjct: 260 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 319
Query: 307 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 366
NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG
Sbjct: 320 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 379
Query: 367 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 426
L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+G
Sbjct: 380 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439
Query: 427 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 486
YLLANAFV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L
Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 499
Query: 487 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 546
Y ++ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +R
Sbjct: 500 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 559
Query: 547 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 606
G+ V EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+
Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619
Query: 607 TELDQDLAKAYLTVLGR----------PDRPRDLELTDLAERSVRLTWIPGDANNSPITD 656
T LD A A L+V+ P+ P DLELTD ++SV+L+W PGD NNSPIT
Sbjct: 620 TTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITK 679
Query: 657 YVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERY 716
+++++E+ +PG+WH ++ G+ +A L+LSPYVNY FRV+A+N +G S PS SE+Y
Sbjct: 680 FIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY 739
Query: 717 RTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVT 776
T + P+ NP V+G G+ +N+ ITW P+N + GP L+Y V WR+++ + W +V
Sbjct: 740 LTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVV 799
Query: 777 VWG-SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNS 835
V S+Y+V TP +VPY I+VQA ND G PEP V+G+SGED P AP V+V V+NS
Sbjct: 800 VANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNS 859
Query: 836 TAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLF 895
T + W+ V +++G L+ YR YYW+ S K +++ +F G + G++ L
Sbjct: 860 TLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLE 919
Query: 896 PYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPN 955
P+S+Y L + VVNG+G+GP S + F TPEGVPSAP ++ P L+++ LEWD P HPN
Sbjct: 920 PFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPN 979
Query: 956 GIMIGYTLKYVAFNGT-KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEA 1014
GI+ YTLKY N T ++G + N+T++T++ + +RY+F A+T GSG
Sbjct: 980 GILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQ 1039
Query: 1015 VTEESPAPPNEA 1026
+TEE+ +EA
Sbjct: 1040 ITEEAVTTVDEA 1051
Score = 288 bits (736), Expect = 3e-77
Identities = 332/1245 (26%), Positives = 517/1245 (41%), Gaps = 188/1245 (15%)
Query: 32 TQPPTITKQSAKDHIVDPRDNILIECEAK-GNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
++ P TK+ + + ++++ C G P P W NS F + + RVS + +
Sbjct: 142 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNS-FQRLPQSERVS-QGLN 199
Query: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQV-------------------- 130
G L + S PE+ +Y C+AR + + + V
Sbjct: 200 GDL---YFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTE 256
Query: 131 ---SKSP-------LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
+KS L P+ N G L+L+C GLP+P+I+W + ++
Sbjct: 257 FYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE-GLPTPIIYWAKED-GMLPKN 314
Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSC---NARFHFTHTIQQKNPFTLKVLTNHPYNDSS 237
+ V + L +V D +Y C NA HTI +
Sbjct: 315 RTVYKNFEKTLQIIHVSEAD-SGNYQCIAKNALGAIHHTISVR----------------- 356
Query: 238 LRNHPDMYSARGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGVPTPDIAWYKKGG 296
+ P ++ TA +VL G D L C A+G P P I+W G
Sbjct: 357 -------------VKAAPYWI----TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGV 399
Query: 297 DL---PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE 353
+ P D ++ + + + +NV E S Y C ASN+ G + V V A P +
Sbjct: 400 PIEIAPDDPSRKIDGDTII-FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILT 458
Query: 354 PKNLI--LAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 411
P N + + L C G+P PT++W G + + T+ Q
Sbjct: 459 PANTLYQVIANRPALLDCAFFGSPLPTIEWF-KGAKGSALHEDIYVLHENGTLEIPVAQK 517
Query: 412 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP 471
S Y C N+ G + + D P + + + V + +C
Sbjct: 518 DSTGTYTCVARNKLGMAKNEVHLEIKD--PTWIVKQPEYAVVQRGSMVSFECKVKHDHTL 575
Query: 472 TLR--WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV 529
+L W K+ + L + L + + +D G YTCVA L L V
Sbjct: 576 SLTVLWLKDNR--ELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSV 633
Query: 530 KDPTR----IYRMPE--------DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI 577
PT +Y +P DQ+ + +VQL D + +T ++ ++ ++
Sbjct: 634 VAPTPTPAPVYDVPNPPFDLELTDQLDK---SVQLSWTPGDDNNSPITKFIIEYEDAMHK 690
Query: 578 GNRMKKEDDSLTIFGVAERDQGSYTCVA---------STELDQDLAKAYLTVLGRPDR-P 627
+ + A+ Y + L + ++ YLT PD+ P
Sbjct: 691 PGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNP 750
Query: 628 RDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEE----DQFQPGVWHDHSKYPGSV 681
+E ++ +TW P G +N P Y V + + D++ V + SKY
Sbjct: 751 TAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKY---- 806
Query: 682 NSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAP-PESNPGDVKGEGTRKNNM 740
V +V Y +V A+N++G + P+ SG P PG+V+
Sbjct: 807 --IVSGTPTFVPYLIKVQALNDMGFAPE--PAVVMGHSGEDLPMVAPGNVRVNVVNSTLA 862
Query: 741 EITWTPMNATSAFGPNLRY-IVKWR-----RRETREAWNNVTVWGSRYVVGQTPVYVP-- 792
E+ W P+ S G Y I W+ +R R + + G P P
Sbjct: 863 EVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFS 922
Query: 793 -YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQ 851
Y + V+ N G+GP + + E P +AP+ +K+ +++L+W+
Sbjct: 923 HYTLNVRVVNGKGEGPASPDRVFNTPEGVP-SAPSSLKIVNPTLDSLTLEWDP--PSHPN 979
Query: 852 GQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRG 911
G L EY Y +S + P ++ R + L + YK G
Sbjct: 980 GILTEYTLKYQPINSTHE----LGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAG 1035
Query: 912 DGPRSETKEFTTPEGVPSAPR-----RFRVRQPNLETI---------NLEWDH--PEHPN 955
G + + TT + P + + P + + N+ W++ PEH N
Sbjct: 1036 SGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVN 1095
Query: 956 GIMIGYTLKY-VAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG--SG 1012
+ ++Y VA + + K+IV +++ F ++ P + Y+ + A G S
Sbjct: 1096 -----FYVEYGVAGSKEEWRKEIVNG---SRSFFGLKGLMPGTAYKVRVGAVGDSGFVSS 1147
Query: 1013 EAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGK 1072
E V E PA + Q DIATQGWFIGLMCA+ALL+LILLIVCFI+R++GGK
Sbjct: 1148 EDVFETGPA----------MASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGK 1197
Query: 1073 YPVREKKDVPLGPE--DPKEEDGSF-DYSD-EDNKPLQ-GSQTSLDGTIKQQESDDSLVD 1127
YPV+EK+D PE KE+DG+F +YSD ED+KPL+ GS+T D T+K+++SDDSLVD
Sbjct: 1198 YPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVD 1257
Query: 1128 YGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYS 1172
YGEG GQFNEDGSFIGQY+ KK+KE EGNESSEA SPVNA+ S
Sbjct: 1258 YGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNS 1302
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 829 bits (2141), Expect = 0.0
Identities = 478/1221 (39%), Positives = 661/1221 (54%), Gaps = 77/1221 (6%)
Query: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
+ LL AIEIP + Q PTI KQS K + P D IECEAKGNP P+F WT++
Sbjct: 15 MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73
Query: 74 RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
F D R+ SGT I + G ++G+Y+CFA NK G A+S I V
Sbjct: 74 NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130
Query: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV GDLYF
Sbjct: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190
Query: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAER 253
+NV +D + DY C A F TI QK P L V + NDSS A + +R
Sbjct: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGS-KANSIKQR 249
Query: 254 TPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNK 310
P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP + EN+ K
Sbjct: 250 KPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGK 309
Query: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCR 370
L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G L+C
Sbjct: 310 TLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCE 369
Query: 371 ANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEH 425
A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC SN H
Sbjct: 370 AEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVH 423
Query: 426 GYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
G +LANA + V+DV P + + + ++ L C FF SP + W K + L+
Sbjct: 424 GTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLE 483
Query: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P++
Sbjct: 484 GRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIP 543
Query: 546 RGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQG 599
+ ++L C K D LK L +SW KD E I R+ + +LTI V DQG
Sbjct: 544 KLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQG 603
Query: 600 SYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVV 659
Y C A T LD +TVL PD P +L L++ RSVRLTW G +NS I++Y+V
Sbjct: 604 IYCCSAHTALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIV 663
Query: 660 QFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS 719
+FE ++ +PG W + ++ G + +L L+P+V YQFRVIA+NEVG S PS PS+ + T
Sbjct: 664 EFEGNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETP 723
Query: 720 GAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWG 779
A P+ NP +++ + ++ M I W P+ + GP L Y V W+ + W TV
Sbjct: 724 PAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN 783
Query: 780 SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAIS 839
V VY PY+++VQA N G GP+P+SV YSGEDYP AP V V+NST +
Sbjct: 784 HTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVK 843
Query: 840 LQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSN 899
+ W+ V D V G+L+ Y+ +W+ SLL ++ F G R G+V L +S
Sbjct: 844 VTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSE 903
Query: 900 YKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMI 959
+ L ++ N +G GP SE F TPEGVP P +V + + +T L W P+ NG +
Sbjct: 904 FHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLT 963
Query: 960 GYTLKYVAFNGT-KVGK-QIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTE 1017
GY L+Y N T ++G+ + +P++ + + + ++Y+F L A T G G+ +TE
Sbjct: 964 GYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITE 1023
Query: 1018 ESPA---------------------PPNEATPTA-------------------------- 1030
ES P P A
Sbjct: 1024 ESSTLGEGSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRG 1083
Query: 1031 -AYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPK 1089
Y DI+TQGWFIGLMCAIALL L+LL VCF+KR+RGGKY V+EK+D+ PE
Sbjct: 1084 REYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQS 1143
Query: 1090 EEDGSF-DYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTV 1148
+D +F +YSD D KPL+GS SL+ ++ ES DSLV+YGEG G F+EDGSFIG Y
Sbjct: 1144 VKDETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAG 1203
Query: 1149 KKDKEETEGNESSEATSPVNA 1169
K+K E N SS AT P+ A
Sbjct: 1204 SKEKGSVESNGSSTATFPLRA 1224
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 732 bits (1889), Expect = 0.0
Identities = 392/1010 (38%), Positives = 556/1010 (55%), Gaps = 31/1010 (3%)
Query: 17 CLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 76
CLL I+IP +L +PP IT+QS + +V P D+I ++CEA G P F WTR+ F
Sbjct: 17 CLL-----IQIPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHF 71
Query: 77 NIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP 134
++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL +P
Sbjct: 72 KPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP 131
Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G NG+LYF+
Sbjct: 132 KWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFA 191
Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERT 254
NV+ D +DY C+A F T TI QK P L+V + + +R
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATN-----------------SMIDRK 234
Query: 255 PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRI 314
P ++P ++S + L+G L+LECIA G PTP I W + G +P+D+ ++N NK L++
Sbjct: 235 PRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQL 294
Query: 315 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGN 374
V EED GEY CLA N +GS RH V V+AAPYWL +P++ + PGE RL C+ G
Sbjct: 295 LKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGR 354
Query: 375 PKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFV 434
P+P V W +NG P++ + + +I + Q S V QC N HG LLANA++
Sbjct: 355 PQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYI 414
Query: 435 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 494
V+ +P ++L+ NQ + + L C FG+P+P+++W + L + Y N
Sbjct: 415 YVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYAN 474
Query: 495 GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLEC 554
G+L I+ ++ D G Y C+A N L+VKD T+I + P + ++G+ V C
Sbjct: 475 GTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTC 534
Query: 555 RVKHDPSLKLTVSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQ 611
+ DPSL+ +++W D L +G+ K ED L I + DQG+Y+CVASTELD
Sbjct: 535 QASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDV 594
Query: 612 DLAKAYLTVLGRPDRPRDLELTD---LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQP 668
++A L V+G P L L+D L + VR++W P + +N+PI Y ++FE+ + P
Sbjct: 595 VESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 654
Query: 669 GVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPG 728
W+ K PG+ S L+LSPYV+Y FRV AIN+ G PS SE T A PE NP
Sbjct: 655 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPV 714
Query: 729 DVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTP 788
DVKGEG NM ITW P+ P ++Y V+WR + TR W V VV T
Sbjct: 715 DVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTS 774
Query: 789 VYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD 848
+VPYEI+VQA N GKGPEP+ IGYSGEDYP+A P + ++NS+A+ ++W V
Sbjct: 775 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 834
Query: 849 TVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVN 908
V+G LR Y YWRE S K+ + P + ++S L PYS+Y LE+ N
Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 894
Query: 909 GRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAF 968
GRG GP SE F+TPEGVP P + + ++ L W P NG++ GY L Y
Sbjct: 895 GRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 953
Query: 969 NGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEE 1018
+ G+ P + P RYRF L A T+ G GEA+ E
Sbjct: 954 DEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVRE 1003
Score = 234 bits (596), Expect = 5e-61
Identities = 299/1200 (24%), Positives = 477/1200 (39%), Gaps = 126/1200 (10%)
Query: 26 EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
EI + P K++ K V+ +++++ C + P + NS+ +I +D RV+
Sbjct: 122 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 181
Query: 86 MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR----IRLQVSKSP------- 134
M + + + + +Y C A + + +R++ + S
Sbjct: 182 MGQNGNLYFANVLTS----DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRL 237
Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
L+P + +V +G PL L+C G P+P I W+ S P+ D+ Q HN L
Sbjct: 238 LFPTNSSSHLVALQGQPLVLECIAE-GFPTPTIKWLRPS-GPMPADRVTYQNHNKTLQLL 295
Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERT 254
V +D +Y C A ++SL + Y E
Sbjct: 296 KVGEED-DGEYRCLA-------------------------ENSLGSARHAYYV--TVEAA 327
Query: 255 PSFMY-PQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG---GDLPSDKAKFENFNK 310
P +++ PQ S + G L+C G P P++ W G +L D+ K+
Sbjct: 328 PYWLHKPQ----SHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ-KYRIQRG 382
Query: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKN--LILAPGEDGRLV 368
AL ++NV D+ C A N+ G + + V P + N + G L+
Sbjct: 383 ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLL 442
Query: 369 CRANGNPKPTVQWMVNGEP--LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 426
C+A G P P+VQW+ LQ P A T+ RD Q + Y C +N+
Sbjct: 443 CKAFGAPVPSVQWLDEDGTTVLQDERFFP---YANGTLGIRDLQANDTGRYFCLAANDQN 499
Query: 427 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLD 485
+ A + V D PR+ + + F S P++ W +G+ L
Sbjct: 500 NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELG 559
Query: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL-EVKDPTRIYRMPEDQVA 544
+ + E+G L I + DQG Y+CVA+ L E++ +L V P + R+ +
Sbjct: 560 DSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLH 619
Query: 545 RRGTTVQLECRVKHDPSLKLTVSWLKDD----------EPLYIGNRMKKEDDSLTIFGVA 594
Q + RV P+ K D E Y ++ S T+ ++
Sbjct: 620 ---LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-KLS 675
Query: 595 ERDQGSYTCVASTELD----QDLAKAYLTVLGRPDR-PRDLELTDLAERSVRLTWIPGDA 649
++ A + +++ +T P++ P D++ ++ +TW P
Sbjct: 676 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 735
Query: 650 N--NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 707
N+P Y VQ+ Q G W + + V S +V Y+ +V A+N G
Sbjct: 736 MDWNAPQVQYRVQWRP-QGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKG 792
Query: 708 HPSLPSERYRTSGAP-PESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRR 766
P SG P++ P E + + + W P++ G Y V + R
Sbjct: 793 PE--PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWRE 850
Query: 767 ETREAWNNVTVWGSRYVV----------GQTPVYVPYEIRVQAENDFGKGPEPESVIGYS 816
++ + + VV G P Y Y + VQA N G+G P S +S
Sbjct: 851 GSQRKHSKRHIHKDHVVVPANTTSVILSGLRP-YSSYHLEVQAFN--GRGSGPASEFTFS 907
Query: 817 GEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQK 876
+ P + + ++T++ L+W S G L Y Y K
Sbjct: 908 TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHN--GVLTGYVLSYHPLDEGGKGQLSFNL 965
Query: 877 RQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFR 935
R P R + L P+ Y+ ++ G G + T G+
Sbjct: 966 RD----PELRTHNLTD-LSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA 1020
Query: 936 VRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENF-SPNQTKFTVQRTD 994
N ++ W E + + + A K G + + S NQ+ +T
Sbjct: 1021 TAGENYSVVS--WVPKEGQCNFR--FHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQ 1076
Query: 995 PVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIAL 1054
P + Y L AV + T A AT+GWFIG + AI L
Sbjct: 1077 PDTDYEIHLFKERMFRHQMAV---------KTNGTGRVRLPPAGFATEGWFIGFVSAIIL 1127
Query: 1055 LVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSF-DYSDEDNKPLQGSQTSLD 1113
L+L+LLI+CFIKRS+GGKY V++K+D + E +D +F +YSD + K SQ SL+
Sbjct: 1128 LLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSSQPSLN 1187
Query: 1114 GTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSL 1173
G IK SDDSL DYG + QFNEDGSFIGQY+ KK+KE GN+SS ATSP+N +L
Sbjct: 1188 GDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVAL 1247
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 724 bits (1870), Expect = 0.0
Identities = 391/1015 (38%), Positives = 556/1015 (54%), Gaps = 36/1015 (3%)
Query: 17 CLLSLGGAIEIPMD-----LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR 71
CLL I+IP + + +PP IT+QS + +V P D+I ++CEA G P F WTR
Sbjct: 17 CLL-----IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR 71
Query: 72 NSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 129
+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL
Sbjct: 72 DGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLM 131
Query: 130 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 189
+P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G NG
Sbjct: 132 AEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG 191
Query: 190 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARG 249
+LYF+NV+ D +DY C+A F T TI QK P L+V +
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATN-----------------S 234
Query: 250 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN 309
+ +R P ++P ++S + L+G L+LECIA G PTP I W + G +P+D+ ++N N
Sbjct: 235 MIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHN 294
Query: 310 KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC 369
K L++ V EED GEY CLA N +GS RH V V+AAPYWL +P++ + PGE RL C
Sbjct: 295 KTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDC 354
Query: 370 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL 429
+ G P+P V W +NG P++ + + +I + Q S V QC N HG LL
Sbjct: 355 QVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLL 414
Query: 430 ANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 489
ANA++ V+ +P ++L+ NQ + + L C FG+P+P+++W + L +
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 490 HVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTT 549
Y NG+L I+ ++ D G Y C+A N L+VKD T+I + P + ++G+
Sbjct: 475 FPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSR 534
Query: 550 VQLECRVKHDPSLKLTVSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
V C+ DPSL+ +++W D L +G+ K ED L I + DQG+Y+CVAS
Sbjct: 535 VTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAS 594
Query: 607 TELDQDLAKAYLTVLGRPDRPRDLELTD---LAERSVRLTWIPGDANNSPITDYVVQFEE 663
TELD ++A L V+G P L L+D L + VR++W P + +N+PI Y ++FE+
Sbjct: 595 TELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFED 654
Query: 664 DQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPP 723
+ P W+ K PG+ S L+LSPYV+Y FRV AIN+ G PS SE T A P
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAP 714
Query: 724 ESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV 783
E NP DVKGEG NM ITW P+ P ++Y V+WR + TR W V V
Sbjct: 715 EKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV 774
Query: 784 VGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWN 843
V T +VPYEI+VQA N GKGPEP+ IGYSGEDYP+A P + ++NS+A+ ++W
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834
Query: 844 RVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLE 903
V V+G LR Y YWRE S K+ + P + ++S L PYS+Y LE
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLE 894
Query: 904 MVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTL 963
+ NGRG GP SE F+TPEGVP P + + ++ L W P NG++ GY L
Sbjct: 895 VQAFNGRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVL 953
Query: 964 KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEE 1018
Y + G+ P + P RYRF L A T+ G GEA+ E
Sbjct: 954 SYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVRE 1008
Score = 234 bits (596), Expect = 5e-61
Identities = 299/1200 (24%), Positives = 477/1200 (39%), Gaps = 126/1200 (10%)
Query: 26 EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
EI + P K++ K V+ +++++ C + P + NS+ +I +D RV+
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 186
Query: 86 MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR----IRLQVSKSP------- 134
M + + + + +Y C A + + +R++ + S
Sbjct: 187 MGQNGNLYFANVLTS----DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRL 242
Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
L+P + +V +G PL L+C G P+P I W+ S P+ D+ Q HN L
Sbjct: 243 LFPTNSSSHLVALQGQPLVLECIAE-GFPTPTIKWLRPS-GPMPADRVTYQNHNKTLQLL 300
Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERT 254
V +D +Y C A ++SL + Y E
Sbjct: 301 KVGEED-DGEYRCLA-------------------------ENSLGSARHAYYV--TVEAA 332
Query: 255 PSFMY-PQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG---GDLPSDKAKFENFNK 310
P +++ PQ S + G L+C G P P++ W G +L D+ K+
Sbjct: 333 PYWLHKPQ----SHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ-KYRIQRG 387
Query: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKN--LILAPGEDGRLV 368
AL ++NV D+ C A N+ G + + V P + N + G L+
Sbjct: 388 ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLL 447
Query: 369 CRANGNPKPTVQWMVNGEP--LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 426
C+A G P P+VQW+ LQ P A T+ RD Q + Y C +N+
Sbjct: 448 CKAFGAPVPSVQWLDEDGTTVLQDERFFP---YANGTLGIRDLQANDTGRYFCLAANDQN 504
Query: 427 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLD 485
+ A + V D PR+ + + F S P++ W +G+ L
Sbjct: 505 NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELG 564
Query: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL-EVKDPTRIYRMPEDQVA 544
+ + E+G L I + DQG Y+CVA+ L E++ +L V P + R+ +
Sbjct: 565 DSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLH 624
Query: 545 RRGTTVQLECRVKHDPSLKLTVSWLKDD----------EPLYIGNRMKKEDDSLTIFGVA 594
Q + RV P+ K D E Y ++ S T+ ++
Sbjct: 625 ---LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-KLS 680
Query: 595 ERDQGSYTCVASTELD----QDLAKAYLTVLGRPDR-PRDLELTDLAERSVRLTWIPGDA 649
++ A + +++ +T P++ P D++ ++ +TW P
Sbjct: 681 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 650 N--NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 707
N+P Y VQ+ Q G W + + V S +V Y+ +V A+N G
Sbjct: 741 MDWNAPQVQYRVQWRP-QGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKG 797
Query: 708 HPSLPSERYRTSGAP-PESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRR 766
P SG P++ P E + + + W P++ G Y V + R
Sbjct: 798 PE--PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWRE 855
Query: 767 ETREAWNNVTVWGSRYVV----------GQTPVYVPYEIRVQAENDFGKGPEPESVIGYS 816
++ + + VV G P Y Y + VQA N G+G P S +S
Sbjct: 856 GSQRKHSKRHIHKDHVVVPANTTSVILSGLRP-YSSYHLEVQAFN--GRGSGPASEFTFS 912
Query: 817 GEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQK 876
+ P + + ++T++ L+W S G L Y Y K
Sbjct: 913 TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHN--GVLTGYVLSYHPLDEGGKGQLSFNL 970
Query: 877 RQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFR 935
R P R + L P+ Y+ ++ G G + T G+
Sbjct: 971 RD----PELRTHNLTD-LSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA 1025
Query: 936 VRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENF-SPNQTKFTVQRTD 994
N ++ W E + + + A K G + + S NQ+ +T
Sbjct: 1026 TAGENYSVVS--WVPKEGQCNFR--FHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQ 1081
Query: 995 PVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIAL 1054
P + Y L AV + T A AT+GWFIG + AI L
Sbjct: 1082 PDTDYEIHLFKERMFRHQMAV---------KTNGTGRVRLPPAGFATEGWFIGFVSAIIL 1132
Query: 1055 LVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSF-DYSDEDNKPLQGSQTSLD 1113
L+L+LLI+CFIKRS+GGKY V++K+D + E +D +F +YSD + K SQ SL+
Sbjct: 1133 LLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYSDNEEKAFGSSQPSLN 1192
Query: 1114 GTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSL 1173
G IK SDDSL DYG + QFNEDGSFIGQY+ KK+KE GN+SS ATSP+N +L
Sbjct: 1193 GDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVAL 1252
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 724 bits (1870), Expect = 0.0
Identities = 391/1015 (38%), Positives = 556/1015 (54%), Gaps = 36/1015 (3%)
Query: 17 CLLSLGGAIEIPMD-----LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR 71
CLL I+IP + + +PP IT+QS + +V P D+I ++CEA G P F WTR
Sbjct: 17 CLL-----IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR 71
Query: 72 NSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 129
+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL
Sbjct: 72 DGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLM 131
Query: 130 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 189
+P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G NG
Sbjct: 132 AEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG 191
Query: 190 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARG 249
+LYF+NV+ D +DY C+A F T TI QK P L+V +
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATN-----------------S 234
Query: 250 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN 309
+ +R P ++P ++S + L+G L+LECIA G PTP I W + G +P+D+ ++N N
Sbjct: 235 MIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHN 294
Query: 310 KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC 369
K L++ V EED GEY CLA N +GS RH V V+AAPYWL +P++ + PGE RL C
Sbjct: 295 KTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDC 354
Query: 370 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL 429
+ G P+P V W +NG P++ + + +I + Q S V QC N HG LL
Sbjct: 355 QVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLL 414
Query: 430 ANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 489
ANA++ V+ +P ++L+ NQ + + L C FG+P+P+++W + L +
Sbjct: 415 ANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERF 474
Query: 490 HVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTT 549
Y NG+L I+ ++ D G Y C+A N L+VKD T+I + P + ++G+
Sbjct: 475 FPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSR 534
Query: 550 VQLECRVKHDPSLKLTVSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
V C+ DPSL+ +++W D L +G+ K ED L I + DQG+Y+CVAS
Sbjct: 535 VTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAS 594
Query: 607 TELDQDLAKAYLTVLGRPDRPRDLELTD---LAERSVRLTWIPGDANNSPITDYVVQFEE 663
TELD ++A L V+G P L L+D L + VR++W P + +N+PI Y ++FE+
Sbjct: 595 TELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFED 654
Query: 664 DQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPP 723
+ P W+ K PG+ S L+LSPYV+Y FRV AIN+ G PS SE T A P
Sbjct: 655 KEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAP 714
Query: 724 ESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV 783
E NP DVKGEG NM ITW P+ P ++Y V+WR + TR W V V
Sbjct: 715 EKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV 774
Query: 784 VGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWN 843
V T +VPYEI+VQA N GKGPEP+ IGYSGEDYP+A P + ++NS+A+ ++W
Sbjct: 775 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 834
Query: 844 RVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLE 903
V V+G LR Y YWRE S K+ + P + ++S L PYS+Y LE
Sbjct: 835 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLE 894
Query: 904 MVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTL 963
+ NGRG GP SE F+TPEGVP P + + ++ L W P NG++ GY L
Sbjct: 895 VQAFNGRGSGPASEF-TFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVL 953
Query: 964 KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEE 1018
Y + G+ P + P RYRF L A T+ G GEA+ E
Sbjct: 954 SYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVRE 1008
Score = 228 bits (581), Expect = 3e-59
Identities = 299/1204 (24%), Positives = 477/1204 (39%), Gaps = 130/1204 (10%)
Query: 26 EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
EI + P K++ K V+ +++++ C + P + NS+ +I +D RV+
Sbjct: 127 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 186
Query: 86 MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR----IRLQVSKSP------- 134
M + + + + +Y C A + + +R++ + S
Sbjct: 187 MGQNGNLYFANVLTS----DNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRL 242
Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
L+P + +V +G PL L+C G P+P I W+ S P+ D+ Q HN L
Sbjct: 243 LFPTNSSSHLVALQGQPLVLECIAE-GFPTPTIKWLRPS-GPMPADRVTYQNHNKTLQLL 300
Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERT 254
V +D +Y C A ++SL + Y E
Sbjct: 301 KVGEED-DGEYRCLA-------------------------ENSLGSARHAYYV--TVEAA 332
Query: 255 PSFMY-PQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG---GDLPSDKAKFENFNK 310
P +++ PQ S + G L+C G P P++ W G +L D+ K+
Sbjct: 333 PYWLHKPQ----SHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQ-KYRIQRG 387
Query: 311 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKN--LILAPGEDGRLV 368
AL ++NV D+ C A N+ G + + V P + N + G L+
Sbjct: 388 ALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLL 447
Query: 369 CRANGNPKPTVQWMVNGEP--LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 426
C+A G P P+VQW+ LQ P A T+ RD Q + Y C +N+
Sbjct: 448 CKAFGAPVPSVQWLDEDGTTVLQDERFFP---YANGTLGIRDLQANDTGRYFCLAANDQN 504
Query: 427 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLD 485
+ A + V D PR+ + + F S P++ W +G+ L
Sbjct: 505 NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELG 564
Query: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL-EVKDPTRIYRMPEDQVA 544
+ + E+G L I + DQG Y+CVA+ L E++ +L V P + R+ +
Sbjct: 565 DSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLH 624
Query: 545 RRGTTVQLECRVKHDPSLKLTVSWLKDD----------EPLYIGNRMKKEDDSLTIFGVA 594
Q + RV P+ K D E Y ++ S T+ ++
Sbjct: 625 ---LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-KLS 680
Query: 595 ERDQGSYTCVASTELD----QDLAKAYLTVLGRPDR-PRDLELTDLAERSVRLTWIPGDA 649
++ A + +++ +T P++ P D++ ++ +TW P
Sbjct: 681 PYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 650 N--NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 707
N+P Y VQ+ Q G W + + V S +V Y+ +V A+N G
Sbjct: 741 MDWNAPQVQYRVQWRP-QGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKG 797
Query: 708 HPSLPSERYRTSGAP-PESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRR 766
P SG P++ P E + + + W P++ G Y V + R
Sbjct: 798 PE--PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWRE 855
Query: 767 ETREAWNNVTVWGSRYVV----------GQTPVYVPYEIRVQAENDFGKGPEPESVIGYS 816
++ + + VV G P Y Y + VQA N G+G P S +S
Sbjct: 856 GSQRKHSKRHIHKDHVVVPANTTSVILSGLRP-YSSYHLEVQAFN--GRGSGPASEFTFS 912
Query: 817 GEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQK 876
+ P + + ++T++ L+W S G L Y Y K
Sbjct: 913 TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHN--GVLTGYVLSYHPLDEGGKGQLSFNL 970
Query: 877 RQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFR 935
R P R + L P+ Y+ ++ G G + T G+
Sbjct: 971 RD----PELRTHNLTD-LSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISA 1025
Query: 936 VRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENF-SPNQTKFTVQRTD 994
N ++ W E + + + A K G + + S NQ+ +T
Sbjct: 1026 TAGENYSVVS--WVPKEGQCNFR--FHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQ 1081
Query: 995 PVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIAL 1054
P + Y L AV + T A AT+GWFIG + AI L
Sbjct: 1082 PDTDYEIHLFKERMFRHQMAV---------KTNGTGRVRLPPAGFATEGWFIGFVSAIIL 1132
Query: 1055 LVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSF-DY----SDEDNKPLQGSQ 1109
L+L+LLI+CFIKRS+GGKY V++K+D + E +D +F +Y SD + K SQ
Sbjct: 1133 LLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQ 1192
Query: 1110 TSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNA 1169
SL+G IK SDDSL DYG + QFNEDGSFIGQY+ KK+KE GN+SS ATSP+N
Sbjct: 1193 PSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINP 1252
Query: 1170 IYSL 1173
+L
Sbjct: 1253 AVAL 1256
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 369 bits (948), Expect = e-102
Identities = 286/988 (28%), Positives = 437/988 (44%), Gaps = 84/988 (8%)
Query: 9 WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64
W FL + L +++ Q P D I+ P D+ + + CE +GNP
Sbjct: 5 WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56
Query: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
PS+ W RN ++ D R S+ GT +I S + G YQC A N G+ LS
Sbjct: 57 PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111
Query: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182
LQ + + V V+EG + L C+PPP P + W+ + + +D R
Sbjct: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171
Query: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNH 241
+SQ G+LY S V D+ + Y C + T+ +VL+ P +LRN
Sbjct: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA---------RVLS--PPTPLTLRND 218
Query: 242 PDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 301
M G E +P ++ +G + +EC A G P P I W K G +PS
Sbjct: 219 GVM----GEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS- 269
Query: 302 KAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361
KA+ L I NV +D+G Y C A N G ++V P+W+++ + L
Sbjct: 270 KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDS 329
Query: 362 GEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNT 421
G R C+A G P+PT +W+ NG PL P E+ ++ + S +YQC
Sbjct: 330 GSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLA 386
Query: 422 SNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKN 478
N++G + A+A + +L P NQL + I+ + + ++C GSP PT+ W K
Sbjct: 387 ENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KK 443
Query: 479 GQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRM 538
G + + + +GSL I K D+G Y C N+ G AE L VK+PTRI
Sbjct: 444 GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELT 503
Query: 539 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTI 590
P+ G ++ L C+ HD SL +T W +P+ + R + L I
Sbjct: 504 PKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMI 563
Query: 591 FGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDAN 650
+ G Y C T D +A L V G P P + + ++ E + L+W P N
Sbjct: 564 RNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADN 623
Query: 651 NSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSAV-LRLSPYVNYQFRVIAINEVG 705
+SPI+ Y +Q F G W P G + SA+ + L+P+V Y+FRV+A N +G
Sbjct: 624 HSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIG 681
Query: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765
+ PS PS RT+ A P++ P +V G R++ + I W P++ G YIV +R
Sbjct: 682 TGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP 741
Query: 766 RETREAWNNVTVWGSR-----YVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDY 820
TR W V S Y P P+E++V N+ G GP + V+ S E
Sbjct: 742 NGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE 800
Query: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
P AAPT+VK ++ + I + W + G+ + + YW++ + R
Sbjct: 801 PSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
Query: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQP 939
SF +++ L + Y + NG G GP S TT + PS AP R Q
Sbjct: 859 SFV------ILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ 912
Query: 940 NLETINLEWDH--PEHPNGIMIGYTLKY 965
+ ++L W+ P ++GY + Y
Sbjct: 913 GSQ-VSLGWEPVIPLANESEVVGYKVFY 939
Score = 31.2 bits (69), Expect = 6.1
Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)
Query: 926 GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 983
G P P V + T L W + + Y L+ + F+ G + K + E +
Sbjct: 595 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 654
Query: 984 NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034
+ +P Y F + A +G+G+ T NEA P A TN
Sbjct: 655 DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 705
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 368 bits (945), Expect = e-101
Identities = 280/953 (29%), Positives = 427/953 (44%), Gaps = 76/953 (7%)
Query: 44 DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
D I+ P D+ + + CE +GNP PS+ W RN ++ D R S+ GT +I S
Sbjct: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159
+ G YQC A N G+ LS LQ + + V V+EG + L C+PP
Sbjct: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
Query: 160 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216
P P + W+ + + +D R +SQ G+LY S V D+ + Y C + T+
Sbjct: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
Query: 217 IQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLL 276
+VL+ P +LRN M G E +P ++ +G +
Sbjct: 279 ---------RVLS--PPTPLTLRNDGVM----GEYEPKIEVHFPFTVTAA----KGTTVK 319
Query: 277 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336
+EC A G P P I W K G +PS KA+ L I NV +D+G Y C A N G
Sbjct: 320 MECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKN 378
Query: 337 RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 396
++V P+W+++ + L G R C+A G P+PT +W+ NG PL P
Sbjct: 379 SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSR 435
Query: 397 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 456
E+ ++ + S +YQC N++G + A+A + +L P NQL + I+
Sbjct: 436 VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIV 493
Query: 457 NRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 513
+ + ++C GSP PT+ W K G + + + +GSL I K D+G Y C
Sbjct: 494 TKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCR 552
Query: 514 ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 573
N+ G AE L VK+PTRI P+ G ++ L C+ HD SL +T W +
Sbjct: 553 GENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQ 612
Query: 574 PL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPD 625
P+ + R + L I + G Y C T D +A L V G P
Sbjct: 613 PIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPG 672
Query: 626 RPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSV 681
P + + ++ E + L+W P N+SPI+ Y +Q F G W P G +
Sbjct: 673 PPGIVIVEEITESTATLSWSPAADNHSPISSYNLQ-ARSPFSLG-WQTVKTVPEIITGDM 730
Query: 682 NSAV-LRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNM 740
SA+ + L+P+V Y+FRV+A N +G+ PS PS RT+ A P++ P +V G R++ +
Sbjct: 731 ESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHEL 790
Query: 741 EITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSR-----YVVGQTPVYVPYEI 795
I W P++ G YIV +R TR W V S Y P P+E+
Sbjct: 791 VIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEV 849
Query: 796 RVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLR 855
+V N+ G GP + V+ S E P AAPT+VK ++ + I + W + G+ +
Sbjct: 850 KVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQ 907
Query: 856 EYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPR 915
+ YW++ + R SF +++ L + Y + NG G GP
Sbjct: 908 GFEVGYWKDMEQEDTAETVKTRGNESFV------ILTGLEGNTLYHFTVRAYNGAGYGPP 961
Query: 916 SETKEFTTPEGVPS-APRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965
S TT + PS AP R Q + ++L W+ P ++GY + Y
Sbjct: 962 SSEVSATTKKSPPSQAPSNLRWEQQGSQ-VSLGWEPVIPLANESEVVGYKVFY 1013
Score = 58.5 bits (140), Expect = 4e-08
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 55/321 (17%)
Query: 40 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
+ D +D + EC+A G P P++ W +N + P+ + +G L+I
Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158
+ G YQC A NK+G ++ ++ +P + L ++V + + ++C
Sbjct: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
Query: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218
P G P P I W + ++KR++ +G L N D + Y C F
Sbjct: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVF----- 557
Query: 219 QKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLE 278
++ ++ V E T + P+ T + G ++L
Sbjct: 558 ---------------------GSAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLN 592
Query: 279 CIASGVPTPDIAWY-----------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 327
C A + D+ +Y ++GG S +A+ + + L I N+ +G Y C
Sbjct: 593 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGC 650
Query: 328 LASNKMGSIRHTISVRVKAAP 348
S+ + V+ P
Sbjct: 651 RVQTTADSVSDEAELLVRGPP 671
Score = 43.9 bits (102), Expect = 0.001
Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)
Query: 31 LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89
L PT K I+ +D ++IEC+ +G+P P+ W + R + ++ R+++
Sbjct: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
Query: 90 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147
+++ + EG+Y C N FG+A +++ + ++ L PK +
Sbjct: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
Query: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198
G + L C V F+ + +PI ++ +Q + DL N++L
Sbjct: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
Score = 31.2 bits (69), Expect = 6.1
Identities = 27/111 (24%), Positives = 42/111 (37%), Gaps = 2/111 (1%)
Query: 926 GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVA-FN-GTKVGKQIVENFSP 983
G P P V + T L W + + Y L+ + F+ G + K + E +
Sbjct: 669 GPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG 728
Query: 984 NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034
+ +P Y F + A +G+G+ T NEA P A TN
Sbjct: 729 DMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN 779
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 365 bits (938), Expect = e-100
Identities = 283/971 (29%), Positives = 433/971 (44%), Gaps = 81/971 (8%)
Query: 8 PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
PW V +F+LCL + P+ + +P + + + + CE KGNP
Sbjct: 4 PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57
Query: 65 PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
P W N + D R S+ G+L+I+ + G YQC A N FGT +S
Sbjct: 58 PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112
Query: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
+LQ + + V V+ G + L C PPP W+ + ++R
Sbjct: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172
Query: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNH----PYNDSSLRN 240
G+LY + V D+ +Y+C T+T+ TNH P LRN
Sbjct: 173 SQETGNLYIAKVEKSDVG-NYTCVV----TNTV-----------TNHKVLGPPTPLILRN 216
Query: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300
M G E +P+ ++ +G + LEC A G P P I W + G +
Sbjct: 217 DGVM----GEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIA 268
Query: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360
KA+ N L I N +ED+G Y C+A N G + A P W+ + ++ +A
Sbjct: 269 RKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVA 328
Query: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420
E+ C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC
Sbjct: 329 MEENVFWECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCL 385
Query: 421 TSNEHGYLLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFK 477
N+HG + +NA +SV+ V P R L R L++V ++C SP P W K
Sbjct: 386 AENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-K 442
Query: 478 NGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR 537
G+ + + E+G+L I + K D G YTC+ATN G A + L VKDPTR+
Sbjct: 443 KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMV 502
Query: 538 MPEDQVARRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LT 589
P G ++ L C+V HD SL + +W + D R+ +D + L
Sbjct: 503 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 562
Query: 590 IFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDA 649
I + + G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG
Sbjct: 563 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPD 622
Query: 650 NNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEV 704
N+SPIT YV+Q F G W S P ++ + V+ L+P+V Y+FR +A N +
Sbjct: 623 NHSPITMYVIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVI 680
Query: 705 GSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR 764
G PS PSE+ RT A PE P +V G G K+ + ITW + G Y+V +
Sbjct: 681 GIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF- 739
Query: 765 RRETREAWNNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGE 818
R + W +TV SRYV V + P+E++V N+ G+GP + + YS E
Sbjct: 740 RPYGKMIW-MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAE 798
Query: 819 DYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQ 878
+ P P + R +++T I + W +G+++ Y YWR +N +
Sbjct: 799 EEPTKPPASIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------AR 851
Query: 879 QASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQ 938
+ G++ ++ L Y L + N G GP S T TT + PS P +
Sbjct: 852 KIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWN 911
Query: 939 PNLETINLEWD 949
+ I L WD
Sbjct: 912 SSDSKIILNWD 922
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 365 bits (937), Expect = e-100
Identities = 277/940 (29%), Positives = 420/940 (44%), Gaps = 68/940 (7%)
Query: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
+ +L+ C A+ +P ++ W N + +P + G LVI + G Y
Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170
QC A N GT +S L+ + KE DPV EG + L CNPP P W+
Sbjct: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
Query: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVL 228
+ T + G+LY + D+ +YSC A H + K+ F+
Sbjct: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFST--KSVFSKFAQ 226
Query: 229 TNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 288
N D+ L A + R P+ Y L G + LEC A G P P
Sbjct: 227 LNLAAEDTRL-------FAPSIKARFPAETY---------ALVGQQVTLECFAFGNPVPR 270
Query: 289 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKA 346
I W K G L ++ L+I +VS ED G Y C A N G R T+ R V+A
Sbjct: 271 IKWRKVDGSL---SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQA 325
Query: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406
P WL + G + R C A G P+PTV+W+ NGEPL S N +AGD + F
Sbjct: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRF 382
Query: 407 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPF 465
+ +YQC N+HG + A+A ++V + P L+P +LI + C
Sbjct: 383 SKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP 442
Query: 466 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 525
+P + W K G ++ V +G+L I+ I + D+G YTC A N +GKA +
Sbjct: 443 RAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
Query: 526 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YI 577
L V+D T+I P G + L+C HDP++ LT +W DD P+ Y
Sbjct: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
Query: 578 GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAE 637
+K+ LTI R G YTC+A T +D +A + V G P P + + D+ +
Sbjct: 562 RTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGD 621
Query: 638 RSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV-----NSAVLRLSPYV 692
+++L+W G N+SPI Y +Q G W P ++ + VL L+P++
Sbjct: 622 TTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAETAQVLGLTPWM 679
Query: 693 NYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSA 752
+Y+FRVIA N +G+ PS PS + RT A P P + G G + + WTPM+
Sbjct: 680 DYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQ 739
Query: 753 FGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPV--YVPYEIRVQAENDFGKGP 807
G Y++ +RR+ + W V G+ +V V Y P+E+++++ N G GP
Sbjct: 740 NGDGFGYLLSFRRQGSTH-WQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
Query: 808 EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSL 867
E + + YS E+ PR APT+V + ++S+ +++ W V D + G L Y YW+
Sbjct: 799 ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQD-MNGILLGYEIRYWKAGD- 856
Query: 868 LKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGV 927
K + R R VS L P + Y + + N G GP S + TT +
Sbjct: 857 -KEAAADRVRTAGLDTSAR----VSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPP 911
Query: 928 PSAPRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965
P P + +++++WD P + GY + Y
Sbjct: 912 PRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
Score = 67.4 bits (163), Expect = 8e-11
Identities = 88/354 (24%), Positives = 124/354 (35%), Gaps = 76/354 (21%)
Query: 44 DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103
D D N+ C A G P P+ W RN +P S + R L D R
Sbjct: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
Query: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159
E G YQC A NK GT ++ +++ L P L+PV G + + C P
Sbjct: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
Query: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219
P V+ W S E + RV+ +G L N+ D + Y+C A
Sbjct: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTCFAE--------- 491
Query: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279
N N + S R + T + SS + G +L L+C
Sbjct: 492 --------------NFMGKANSTGILSVRDATKITLA-------PSSADINLGDNLTLQC 530
Query: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE------------EDSGEYFC 327
AS PT D+ + D P D F+ R TNV E G+Y C
Sbjct: 531 HASHDPTMDLTFTWTLDDFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
Query: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 381
+A + S +V V+ PG G +V R G+ + W
Sbjct: 588 MAQTVVDSASKEATVLVRG-------------PPGPPGGVVVRDIGDTTIQLSW 628
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 365 bits (937), Expect = e-100
Identities = 281/926 (30%), Positives = 412/926 (44%), Gaps = 87/926 (9%)
Query: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 112
Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 113 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 172
Query: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARF-HFTHTIQQK--NPF 223
+ + IT DKR VSQ NG+LY +NV D + +YSC T ++ K
Sbjct: 173 LLNEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSKFIPLI 230
Query: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 283
+ T PY + D+Y+ L G ++ LEC A G
Sbjct: 231 PIPERTTKPYPADIVVQFKDVYA-----------------------LMGQNVTLECFALG 267
Query: 284 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 343
P PDI W K +PS A+ L+I N+ ED G Y C A N G +H +
Sbjct: 268 NPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 326
Query: 344 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 403
V+A P W++ + + G D C A G P PT++W+ NG G+
Sbjct: 327 VQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GEL 376
Query: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLD 462
++ D + +YQC N +G + ANA + +L + P ++P + I R ++
Sbjct: 377 RLY-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 435
Query: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
C +P P W K G ++ ++E+GSLEI I + D GIYTC A N GKA
Sbjct: 436 CKPKAAPKPKFSWSK-GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 494
Query: 523 NQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEP 574
+ L + DPTRI P + G ++C DP+L LT W +
Sbjct: 495 STGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENI 554
Query: 575 LYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTD 634
Y N M + L I + G YTC A T +D A A L V G P P L + D
Sbjct: 555 HYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIED 614
Query: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSA-VLRLS 689
+ SV LTW G N+SPI+ Y +Q + W D P G++ +A + L
Sbjct: 615 IRATSVALTWSRGSDNHSPISKYTIQTK--TILSDDWKDAKTDPPIIEGNMEAARAVDLI 672
Query: 690 PYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 749
P++ Y+FRV+A N +G PS+PS R +T GA P P DV G G R + ITW P++
Sbjct: 673 PWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSR 732
Query: 750 TSAFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV--YVPYEIRVQAENDFG 804
+G N YIV ++ + E W VTV RYV + ++++V+A N+ G
Sbjct: 733 EYHYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 791
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
GP + S +D P APTEV V+V++S+ IS+ W V V+ Y A + +E
Sbjct: 792 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 851
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
+ + SQ+ + L P + Y +E+ N G GP S+ E T
Sbjct: 852 EAANRVQVTSQEYSAR----------LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 901
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDH 950
+ PS P R + + WDH
Sbjct: 902 KAPPSQPPRIISSVRSGSRYIITWDH 927
Score = 68.2 bits (165), Expect = 4e-11
Identities = 92/403 (22%), Positives = 143/403 (35%), Gaps = 57/403 (14%)
Query: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 230 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 284
Query: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 285 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 339
Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 340 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 388
Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263
Y C A + LK+L P E P
Sbjct: 389 -YQCIAENTYGAIYANAE---LKILALAP-----------------TFEMNP-------M 420
Query: 264 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSG 323
+ +G +++EC P P +W K L + + +L I N++ D G
Sbjct: 421 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 480
Query: 324 EYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQW 381
Y C A N G T ++ + + P N + GE+ + C A+ +P T W
Sbjct: 481 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 540
Query: 382 MVNGEPLQSAPPNPNRE-----VAGDTIIFRDTQISSRAVYQC 419
NG + N + + + ++ R+ Q+ Y C
Sbjct: 541 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 583
Score = 53.9 bits (128), Expect = 9e-07
Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 9/180 (5%)
Query: 455 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 514
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 57 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 116
Query: 515 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 117 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 175
Query: 572 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTC-VASTELDQDLAKAYLTVLGRPDR 626
+ P++I + + + +L I V D+G+Y+C V+S + + + ++ ++ P+R
Sbjct: 176 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 235
Score = 36.6 bits (83), Expect = 0.14
Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 13/214 (6%)
Query: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
P P +++ + +T+++L W+R + Y + ++L + W K
Sbjct: 603 PPGPPGGLRIEDIRATSVALTWSRGSDNH-----SPISKYTIQTKTILSDDWKDAKTDPP 657
Query: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG-PRSETKEFTTPEGVPS-APRRFRVRQ 938
G+ L P+ Y+ +V N G G P + T P+ AP
Sbjct: 658 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 717
Query: 939 PNLETINLEWD--HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 996
+ + W E+ G GY + + F+G + K V N + + P
Sbjct: 718 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPS 777
Query: 997 SRYRFTLSARTQVGSGE----AVTEESPAPPNEA 1026
+ ++ + A G G AV + P+EA
Sbjct: 778 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEA 811
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 365 bits (937), Expect = e-100
Identities = 281/926 (30%), Positives = 412/926 (44%), Gaps = 87/926 (9%)
Query: 53 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
Query: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARF-HFTHTIQQK--NPF 223
+ + IT DKR VSQ NG+LY +NV D + +YSC T ++ K
Sbjct: 162 LLNEFPVFITMDKRRFVSQ-TNGNLYIANVEASD-KGNYSCFVSSPSITKSVFSKFIPLI 219
Query: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 283
+ T PY + D+Y+ L G ++ LEC A G
Sbjct: 220 PIPERTTKPYPADIVVQFKDVYA-----------------------LMGQNVTLECFALG 256
Query: 284 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 343
P PDI W K +PS A+ L+I N+ ED G Y C A N G +H +
Sbjct: 257 NPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIY 315
Query: 344 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 403
V+A P W++ + + G D C A G P PT++W+ NG G+
Sbjct: 316 VQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GEL 365
Query: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLD 462
++ D + +YQC N +G + ANA + +L + P ++P + I R ++
Sbjct: 366 RLY-DVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424
Query: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
C +P P W K G ++ ++E+GSLEI I + D GIYTC A N GKA
Sbjct: 425 CKPKAAPKPKFSWSK-GTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
Query: 523 NQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEP 574
+ L + DPTRI P + G ++C DP+L LT W +
Sbjct: 484 STGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENI 543
Query: 575 LYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTD 634
Y N M + L I + G YTC A T +D A A L V G P P L + D
Sbjct: 544 HYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIED 603
Query: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP----GSVNSA-VLRLS 689
+ SV LTW G N+SPI+ Y +Q + W D P G++ +A + L
Sbjct: 604 IRATSVALTWSRGSDNHSPISKYTIQTK--TILSDDWKDAKTDPPIIEGNMEAARAVDLI 661
Query: 690 PYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNA 749
P++ Y+FRV+A N +G PS+PS R +T GA P P DV G G R + ITW P++
Sbjct: 662 PWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSR 721
Query: 750 TSAFGPNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPV--YVPYEIRVQAENDFG 804
+G N YIV ++ + E W VTV RYV + ++++V+A N+ G
Sbjct: 722 EYHYGNNFGYIVAFKPFDGEE-WKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKG 780
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
GP + S +D P APTEV V+V++S+ IS+ W V V+ Y A + +E
Sbjct: 781 DGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKE 840
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
+ + SQ+ + L P + Y +E+ N G GP S+ E T
Sbjct: 841 EAANRVQVTSQEYSAR----------LENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDH 950
+ PS P R + + WDH
Sbjct: 891 KAPPSQPPRIISSVRSGSRYIITWDH 916
Score = 68.2 bits (165), Expect = 4e-11
Identities = 92/403 (22%), Positives = 143/403 (35%), Gaps = 57/403 (14%)
Query: 25 IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
I IP T+P P KD N+ +EC A GNP P W + + P
Sbjct: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273
Query: 84 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
+ SG ++ F E EG Y+C A N G ++ R+ V P W E+++
Sbjct: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328
Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
V G+ L C G P P I W+ K H G+L +V ++
Sbjct: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377
Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGT 263
Y C A + LK+L P E P
Sbjct: 378 -YQCIAENTYGAIYANAE---LKILALAP-----------------TFEMNP-------M 409
Query: 264 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSG 323
+ +G +++EC P P +W K L + + +L I N++ D G
Sbjct: 410 KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469
Query: 324 EYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQW 381
Y C A N G T ++ + + P N + GE+ + C A+ +P T W
Sbjct: 470 IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529
Query: 382 MVNGEPLQSAPPNPNRE-----VAGDTIIFRDTQISSRAVYQC 419
NG + N + + + ++ R+ Q+ Y C
Sbjct: 530 SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTC 572
Score = 53.9 bits (128), Expect = 9e-07
Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 9/180 (5%)
Query: 455 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 514
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
Query: 515 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
Query: 572 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTC-VASTELDQDLAKAYLTVLGRPDR 626
+ P++I + + + +L I V D+G+Y+C V+S + + + ++ ++ P+R
Sbjct: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPER 224
Score = 36.6 bits (83), Expect = 0.14
Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 13/214 (6%)
Query: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
P P +++ + +T+++L W+R + Y + ++L + W K
Sbjct: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNH-----SPISKYTIQTKTILSDDWKDAKTDPP 646
Query: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG-PRSETKEFTTPEGVPS-APRRFRVRQ 938
G+ L P+ Y+ +V N G G P + T P+ AP
Sbjct: 647 IIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGG 706
Query: 939 PNLETINLEWD--HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 996
+ + W E+ G GY + + F+G + K V N + + P
Sbjct: 707 GRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPS 766
Query: 997 SRYRFTLSARTQVGSGE----AVTEESPAPPNEA 1026
+ ++ + A G G AV + P+EA
Sbjct: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEA 800
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 363 bits (932), Expect = e-100
Identities = 274/975 (28%), Positives = 424/975 (43%), Gaps = 87/975 (8%)
Query: 8 PWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHI-VDPRDN-ILIECEAKGNPAP 65
PW L + LGG + L Q P K+ + V D I + CEA+GNP+P
Sbjct: 4 PWKQLILLSFIGCLGGEL-----LLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSP 58
Query: 66 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 125
+ W N +++ + R + G LV+ G YQCFA N GT +S
Sbjct: 59 HYRWQLNGSDIDMSMEHRYKLN--GGNLVV---INPNRNWDTGTYQCFATNSLGTIVSRE 113
Query: 126 IRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD--KRV 183
+LQ + + + V V+EG + L C PPP W+ + ++ +R
Sbjct: 114 AKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRF 173
Query: 184 SQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPD 243
G LY S V D+ +Y+C T+ +P L + ++
Sbjct: 174 VSQETGHLYISKVEPSDVG-NYTCVVTSMVTNARVLGSPTPLVLRSD------------- 219
Query: 244 MYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKA 303
G E +P+ ++ +G + LEC A G P P I W + G S K
Sbjct: 220 --GVMGEYEPKIEVQFPETLPAA----KGSTVKLECFALGNPIPQINWRRSDGLPFSSKI 273
Query: 304 KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGE 363
K F+ L I N +ED+G Y C+A N G + A P+W+ K++ +A +
Sbjct: 274 KLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVED 333
Query: 364 DGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSN 423
CRA+G PKP+ +W+ NG L ++ + + ++ ++QC N
Sbjct: 334 SLYWECRASGKPKPSYRWLKNGAALVL---EERTQIENGALTISNLSVTDSGMFQCIAEN 390
Query: 424 EHGYLLANAFVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGS 482
+HG + ++A + V+ P +P +L++V + + LDC SP W K G S
Sbjct: 391 KHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW-KKGDVS 449
Query: 483 NLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQ 542
+ + +G L+I + K D G YTC+A N GKA L V +PTRI P +
Sbjct: 450 VQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNM 509
Query: 543 VARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDS----LTI 590
G +V L C+V+HDP L + +W K D G+ +K S L I
Sbjct: 510 DVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKD-----GSHFEKVGGSSSGDLMI 564
Query: 591 FGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDAN 650
+ + G Y C+ T +D + A L V G P P ++++ ++ + + +L+W G N
Sbjct: 565 RNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDN 624
Query: 651 NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEVG 705
+SP+ Y +Q F G W + P ++ + V+ L+P+V Y+FRV+A N++G
Sbjct: 625 HSPVISYSIQ-ARTPFSVG-WQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIG 682
Query: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765
PSLPSE+ RT A PE P +V G G ++ + ITW P+ G Y+V +R
Sbjct: 683 GGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRP 742
Query: 766 RETREAWNNVTVWGSRYVVG-QTPVYV----------PYEIRVQAENDFGKGPEPESVIG 814
VT W V TP YV PYE++V N+ G+GP
Sbjct: 743 L-------GVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTV 795
Query: 815 YSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVS 874
+S E+ P AP++V ++S+ I + WN + G L Y YW K S
Sbjct: 796 FSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGG--KEESSS 853
Query: 875 QKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRF 934
+ + + RLRG+ S L Y+ + N G GP S T TT + PS P
Sbjct: 854 KMKVAGNETSARLRGLKSNLAYYTAVR----AYNSAGAGPFSATVNVTTKKTPPSQPPGN 909
Query: 935 RVRQPNLETINLEWD 949
V + L W+
Sbjct: 910 VVWNATDTKVLLNWE 924
Score = 32.0 bits (71), Expect = 3.6
Identities = 27/107 (25%), Positives = 39/107 (36%), Gaps = 6/107 (5%)
Query: 926 GVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIV----ENF 981
G P P +V + T L W + + +I Y+++ A VG Q V E
Sbjct: 596 GSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQ--ARTPFSVGWQTVTTVPEVI 653
Query: 982 SPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATP 1028
TV +P Y F + A ++G GE EA P
Sbjct: 654 DGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVP 700
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 319 bits (818), Expect = 9e-87
Identities = 249/938 (26%), Positives = 400/938 (42%), Gaps = 60/938 (6%)
Query: 50 RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 109
+ +++ C A G P+P + W +N + R G+L I+ ++ G
Sbjct: 43 KSEVILNCAANGYPSPHYRWKQNGTDIDFTMS--YHYRLDGGSLAIN---SPHTDQDIGM 97
Query: 110 YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 169
YQC A N GT LS + +LQ + + + V V+EG + L C PPP W
Sbjct: 98 YQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAW 157
Query: 170 MSSSMEPITQD--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
+ Q+ +R G+LY + V D+ +Y+C Q P L
Sbjct: 158 TFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVG-NYTCFITNKEAQRSVQGPPTPLVQ 216
Query: 228 LTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 287
T+ G E +P+ ++ + + LEC A G P P
Sbjct: 217 RTD---------------GVMGEYEPKIEVRFPETIQAA----KDSSVKLECFALGNPVP 257
Query: 288 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 347
DI+W + G K K+ L I N +ED G Y C+ASN G + A
Sbjct: 258 DISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAP 317
Query: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFR 407
P W + +N L+ ++ C+A+G P P W+ NGE L P ++ T+I
Sbjct: 318 PEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLN---PEERIQIENGTLIIT 374
Query: 408 DTQISSRAVYQCNTSNEHGYLLANAFVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFF 466
+S VYQC N++ + ANA + VL P SP + V + + C
Sbjct: 375 MLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPN 434
Query: 467 GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 526
P + W K G + + E+GSL+I I + D G YTC+ATN G A+N
Sbjct: 435 AFPRAAISW-KRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGS 493
Query: 527 LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK---- 582
L VK+ T I P G ++ L C+V HDPS+++ W + + + + +
Sbjct: 494 LIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFER 553
Query: 583 ---KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERS 639
+ L I + G Y C T L+ A A + V G P P D+++ D++ +
Sbjct: 554 IGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTT 613
Query: 640 VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP-----GSVNSAVLRLSPYVNY 694
+L+W G NNSPI + +Q F G W + P + N+ V+ LSP+V Y
Sbjct: 614 SQLSWRAGPDNNSPIQIFTIQ-TRTPFSVG-WQAVATVPEILNGKTYNATVVGLSPWVEY 671
Query: 695 QFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFG 754
+FRV+A N +G PS PSE RT + P P ++ G G ++ + ITW + G
Sbjct: 672 EFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNG 731
Query: 755 PNLRYIVKWRRRETREAWNN---VTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEP 809
YI+ +R + W+ +V SR+V + P+E++V N+ G+G
Sbjct: 732 EGFGYIIMFRPVGS-TTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLS 790
Query: 810 ESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLK 869
I YSGED P+ AP ++ +++ + + WN + + G++ Y YW + S K
Sbjct: 791 TVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDS--K 848
Query: 870 NLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS 929
+ + R + + G+ + +++ + N G GP S TT + PS
Sbjct: 849 ESMIGKIRVSGNVTTKNITGLKANTIYFASVR----AYNTAGTGPSSPPVNVTTKKSPPS 904
Query: 930 APRRFRVRQPNLETINLEWDHPE--HPNGIMIGYTLKY 965
P + + L W+H + ++GY + Y
Sbjct: 905 QPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILY 942
Score = 78.6 bits (192), Expect = 3e-14
Identities = 101/424 (23%), Positives = 171/424 (40%), Gaps = 54/424 (12%)
Query: 23 GAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDP 82
G E +++ P TI Q+AKD ++ +EC A GNP P W R + P
Sbjct: 223 GEYEPKIEVRFPETI--QAAKD------SSVKLECFALGNPVPDISWRR------LDGSP 268
Query: 83 RVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD 142
+ S + I +E EG Y+C A N G L+ + +L P W ++ +
Sbjct: 269 LPGKVKYSKSQAI-LEIPNFQQEDEGFYECIASNLRGRNLA-KGQLIFYAPPEW-EQKIQ 325
Query: 143 PVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQ 202
+ L +C G P+P W+ + E + ++R+ Q NG L + + + D
Sbjct: 326 NTHLSIYDNLLWECK-ASGKPNPWYTWLKNG-ERLNPEERI-QIENGTLIITMLNVSDSG 382
Query: 203 TDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQG 262
Y C A +N + + Y ++ LR V P F
Sbjct: 383 V-YQCAA----------ENKYQI------IYANAELR----------VLASAPDFS-KSP 414
Query: 263 TASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDS 322
V G D+++ C + P I+W + L K F + +L+I N++ D+
Sbjct: 415 VKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDA 474
Query: 323 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV--Q 380
G Y C+A+N+ G+ ++T S+ VK P + + GE L C+ + +P V
Sbjct: 475 GSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFV 534
Query: 381 WMVNGEPLQSAPPNPNRE-VAGDTI---IFRDTQISSRAVYQCNTSNEHGYLLANAFVSV 436
W NG+ + + E + G+++ + R+ Q+ Y C L A A + V
Sbjct: 535 WFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIV 594
Query: 437 LDVP 440
P
Sbjct: 595 RGPP 598
Score = 33.9 bits (76), Expect = 0.94
Identities = 44/231 (19%), Positives = 81/231 (35%), Gaps = 16/231 (6%)
Query: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQA 880
P P +V+V ++ST L W + Q+ + + + W +
Sbjct: 597 PPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQI-----FTIQTRTPFSVGWQAVATVPE 651
Query: 881 SFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFT-TPEGVPS-APRRFRVRQ 938
G V L P+ Y+ +V N G G SE E T VP AP
Sbjct: 652 ILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGG 711
Query: 939 PNLETINLEWDH--PEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 996
+ + + W+ E NG GY + + T K+ V + ++ + + P+
Sbjct: 712 GSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPL 771
Query: 997 SRYRFTLSARTQVGSGEAVT-------EESPAPPNEATPTAAYTNNQADIA 1040
S + + G G T E+ P T +++ ++ +++
Sbjct: 772 SPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVS 822
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 265 bits (676), Expect = 2e-70
Identities = 242/938 (25%), Positives = 389/938 (41%), Gaps = 55/938 (5%)
Query: 108 GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVI 167
G Y+C RN+ G L + +QV+ + + V Q G L P P P +
Sbjct: 165 GFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQ-GRAAILNLLPITSYPRPQV 223
Query: 168 FWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
W + I ++ N V+L +D A ++ + +KN
Sbjct: 224 TWFREGHKIIPSNRIAITLEN-----QLVILATTTSD----AGAYYVQAVNEKNG----- 269
Query: 228 LTNHPYNDSSLRNHPDMYSARGVAER-TPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 286
N +S H + G E P+ + P G S +V + LECIAS P
Sbjct: 270 -----ENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRS--VVAGSSETTLECIASARPV 322
Query: 287 PDIA--WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC---LASNKMGSIRHTIS 341
D++ W + G + S +F + L I+N + D+G Y C L + R T
Sbjct: 323 EDLSVTWKRNGVRITSG---LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAF 379
Query: 342 VRVKAAPYWLDEPKNLILAPGEDG-RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV- 399
+ + PY+ EP++ I A E+ + C+A G P PT+QW + + S NP +V
Sbjct: 380 LFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISI-SRLQNPRYKVL 438
Query: 400 AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 459
A + + + ++QC SNE G + + ++ V ++ P + + R V
Sbjct: 439 ASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAP-VFTQRPVDTTVTDGMTA 497
Query: 460 RLDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
L C G+P P + W + ++ + + E+G L+I + +D G YTC A N
Sbjct: 498 ILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAAN 557
Query: 517 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD---E 573
G L V + T I PED V +GTT L C HDP + L W KD+
Sbjct: 558 TEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALT 617
Query: 574 PLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELT 633
P + ++D SL I D G Y+C +E D A L V+ P P++L ++
Sbjct: 618 PSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
Query: 634 DLAERS--VRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPY 691
+ S V L+W+ NSPI Y+V+ E+ P H + P V L+P
Sbjct: 678 PNSSHSHAVVLSWVRPFDGNSPILYYIVELSENN-SPWKVHLSNVGPEMTGVTVSGLTPA 736
Query: 692 VNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATS 751
YQFRV A+NEVG S + R PP + P ++ G ++ + W P T
Sbjct: 737 RTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETE 796
Query: 752 AFGPNLRYIVKWRRRETREAW--NNVTVWGSRY-VVGQTPVYVPYEIRVQAENDFGKGPE 808
G YI+++R + N+T Y +V ++ YEI+V A N G G
Sbjct: 797 HNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF 856
Query: 809 PESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLL 868
+V Y+ + P A P V+ +NST I WN + G + Y+ W +
Sbjct: 857 SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPE 916
Query: 869 KNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVP 928
V+ F G G ++ L ++ Y ++ GDGP S + T E P
Sbjct: 917 A---VTVVTIAPDFHGVH-HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKP 972
Query: 929 SAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKF 988
A + ++ + W P NGI+ GY + + + + ++ + ++
Sbjct: 973 GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG--RNDSRLTHTLNSTTHEY 1030
Query: 989 TVQRTDPVSRYRFTLSARTQVGSG--EAVTEESPAPPN 1024
+Q ++ Y ++A T VG+G + T S PP+
Sbjct: 1031 KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPD 1068
Score = 130 bits (326), Expect = 1e-29
Identities = 107/420 (25%), Positives = 185/420 (44%), Gaps = 25/420 (5%)
Query: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEE----DQFQPGVWHDHSKYPG 679
P P +L +++++ RS L + PG + I+ ++V+ + D+ + ++ P
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
Query: 680 SVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNN 739
+ + L+PY +Y+FR+ +N VG S S S +T APP+ P V + +
Sbjct: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
Query: 740 MEITWTPMNATSAFG--PNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPVYVPYE 794
+ + W P+ + G ++ Y +K+ R + + + V + + + ++ YE
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYE 1249
Query: 795 IRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQL 854
+++QA N G GP E V G + E P AAP V ++ST I L W V G +
Sbjct: 1250 LQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLI 1309
Query: 855 REYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG- 913
Y+ + R L + R +++ L + Y+L+++ G+G
Sbjct: 1310 LGYKILF-RAKDL-----DPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGV 1363
Query: 914 PRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKV 973
P + T + P P R + L ++ + W PE PNGI++GY + Y + +
Sbjct: 1364 PSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPH 1423
Query: 974 GKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAV--------TEESPAPPNE 1025
VE +FT P S Y F LSA+T+ G GE + E PAPP E
Sbjct: 1424 TFTTVE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
Score = 126 bits (317), Expect = 1e-28
Identities = 112/437 (25%), Positives = 177/437 (40%), Gaps = 40/437 (9%)
Query: 623 RPDRPRDLEL--TDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGS 680
RP PR+L + ++ RS+RL W+PG SPI + +Q E G W +S
Sbjct: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRE--LPRGEWQTYSSSISH 1533
Query: 681 VNSAVL--RLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKN 738
+A + RL P+ +Y+ R+ A N++G S S +E T P PG V +
Sbjct: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
Query: 739 NMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNN--------------VTVWGSRYVV 784
++ I W P S G Y + +R E +T S V
Sbjct: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
Query: 785 GQTPV-----------YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM 833
+ Y YE+ + A N G+ P V + GE P AP V+V +
Sbjct: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPL 1713
Query: 834 NSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSR 893
++ + + W+ ++ G ++ Y+ YYW S +N K P RL+ + S
Sbjct: 1714 TASQLEVTWDPPPPESQNGNIQGYKIYYWEADS--QNETEKMKVLFLPEPVVRLKNLTS- 1770
Query: 894 LFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEH 953
++ Y + + N GDGP+S+ ++ T + P AP + T+N+ W P
Sbjct: 1771 ---HTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
Query: 954 PNGIMIGYTLKYVAFNGTK-VGKQIVENFSPN-QTKFTVQRTDPVSRYRFTLSARTQVGS 1011
NGI+ GY + Y + V K + N Q V+ Y F + ART +
Sbjct: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-ITY 1886
Query: 1012 GEAVTEESPAPPNEATP 1028
G + A P E +P
Sbjct: 1887 GPELQANITAGPAEGSP 1903
Score = 74.7 bits (182), Expect = 5e-13
Identities = 96/423 (22%), Positives = 164/423 (38%), Gaps = 47/423 (11%)
Query: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNS 683
P P L ++ SVR+ W P + N I Y + + P H+ V +
Sbjct: 1378 PGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-----HTFTTVEVGA 1432
Query: 684 AVLR-----LSPYVNYQFRVIAINEVGSSHP---SLPSERYRTSGAPPESNPGDVKGEGT 735
V + L+P Y FR+ A G P ++ + R APP V
Sbjct: 1433 TVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL--VPQAEV 1490
Query: 736 RKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW----NNVTVWGSRYVVGQTPVYV 791
++ + W P + P +RY R R W ++++ + VV + +
Sbjct: 1491 TARSLRLQWVP--GSDGASP-IRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFT 1547
Query: 792 PYEIRVQAENDFGKGP---EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSD 848
Y++R++A ND G E E+V +D P P V ++++ +QW +
Sbjct: 1548 SYKLRLKATNDIGDSDFSSETEAVTTL--QDVPGEPPGSVSATPHTTSSVLIQWQPPRDE 1605
Query: 849 TVQGQLREYRAYY---------WRESSLLKN--LWVSQKRQQASFPGDRLRGV-----VS 892
++ G L+ YR YY E+ LKN ++ Q+SF ++
Sbjct: 1606 SLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELT 1665
Query: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPS-APRRFRVRQPNLETINLEWD-- 949
L Y Y++ M N G+ P S E E P+ AP+ +V + + WD
Sbjct: 1666 HLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPP 1725
Query: 950 HPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQV 1009
PE NG + GY + Y + +++ F P + ++ ++Y ++SA
Sbjct: 1726 PPESQNGNIQGYKIYYWEADSQNETEKMKVLFLP-EPVVRLKNLTSHTKYLVSISAFNAA 1784
Query: 1010 GSG 1012
G G
Sbjct: 1785 GDG 1787
Score = 60.8 bits (146), Expect = 7e-09
Identities = 104/485 (21%), Positives = 184/485 (37%), Gaps = 54/485 (11%)
Query: 620 VLGRPDRPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEEDQFQPGVWHD---- 673
V G P P + T SV + W P ++ N + Y + + E +++ G +
Sbjct: 1577 VPGEP--PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTL 1634
Query: 674 ------HSKYPG-----SVNSA-------VLRLSPYVNYQFRVIAINEVGSSHPSLPSER 715
H++ +VNS+ + L Y Y+ + A N +G S S P E
Sbjct: 1635 KNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEV 1694
Query: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRY-IVKWRRRETREAWNN 774
+ AP + P +V+ + +E+TW P S G Y I W E
Sbjct: 1695 FVGEAAPAMA-PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKM 1753
Query: 775 VTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRV 832
++ VV + + Y + + A N G GP+ + G + + P AP+ +
Sbjct: 1754 KVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSE 1812
Query: 833 MNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVS 892
+ ST +++ W + G L+ YR Y L + K G+ R +
Sbjct: 1813 ITSTTLNVSWGEPAA--ANGILQGYRVVY----EPLAPVQGVSKVVTVEVRGNWQRWLKV 1866
Query: 893 RLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP-EGVPSAPRRFRVRQPNLETINLEWDHP 951
R V GP + P EG P +PR V + E + L+W
Sbjct: 1867 RDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE-LTLQWTEG 1925
Query: 952 EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSR---YRFTLSARTQ 1008
+ GY ++ + + V++ + T +T+ D + + Y F + A +
Sbjct: 1926 HSGDTPTTGYVIE-ARPSDEGLWDMFVKDIPRSATSYTLS-LDKLRQGVTYEFRVVAVNE 1983
Query: 1009 VGSGEAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRS 1068
G GE P N +T +A +A + WF+ +M +L+V++L++ +
Sbjct: 1984 AGYGE--------PSNPSTAVSAQV--EAPFYEEWWFLLVMALSSLIVILLVVFALVLHG 2033
Query: 1069 RGGKY 1073
+ KY
Sbjct: 2034 QNKKY 2038
Score = 58.2 bits (139), Expect = 5e-08
Identities = 73/339 (21%), Positives = 140/339 (41%), Gaps = 50/339 (14%)
Query: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
+ +PP T + + + + I C+A G P P+ W +++ + ++PR +
Sbjct: 382 IIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASG 441
Query: 91 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
G + RPE+ G +QCFA N+ G ++ + +P++ + +D V +G
Sbjct: 442 GLRIQKL----RPED-SGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD-TTVTDGM 495
Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG---HNGDLYFSNVMLQDMQTDYSC 207
L+C G P P I W + + R+ + +G L + V +QD +Y+C
Sbjct: 496 TAILRCE-VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD-AGNYTC 553
Query: 208 NARFHFTHTIQQKN-PFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASS 266
A +T N TL V +N +S+ + P+
Sbjct: 554 YA----ANTEGSLNASATLTV-----WNRTSIVHPPE----------------------D 582
Query: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKF-ENFNKALRITNVSEEDS 322
+V++G L C A+ P + + K ++ PS ++ + +L I+ D
Sbjct: 583 HVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI 642
Query: 323 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAP 361
G+Y C ++ G+ + V P+ P+NL+++P
Sbjct: 643 GDYSCEIVSEGGNDSRMARLEVIELPH---SPQNLLVSP 678
Score = 57.8 bits (138), Expect = 6e-08
Identities = 88/392 (22%), Positives = 146/392 (37%), Gaps = 36/392 (9%)
Query: 267 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 326
Q+ L G L+L C+A G + W + +L + ++++ I ++ + D+G Y
Sbjct: 114 QIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI-----IPSLQKLDAGFYR 168
Query: 327 CLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRL-VCRANGNPKPTVQWMVN 384
C+ N+MG+ ++ V+V ++D + ++ G L + P+P V W
Sbjct: 169 CVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
Query: 385 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE-HGYLLANAFVSVL------ 437
G + P N + ++ T S Y NE +G + F+ +
Sbjct: 229 GHKI--IPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVG 286
Query: 438 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 494
+ P ++ P V + T L+C P+ L G + G +
Sbjct: 287 TPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSF--G 344
Query: 495 GSLEIKMIRKEDQGIYTCVATNILGKAENQVR----LEVKDPTRIYRMPEDQV-ARRGTT 549
L I D G Y C A + G A R L + +P PE ++ A T
Sbjct: 345 RRLTISNPTSADTGPYVCEAA-LPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEET 403
Query: 550 VQLECRVKHDPSLKLTVSWLKDDEPL-YIGNRMKK--EDDSLTIFGVAERDQGSYTCVAS 606
V + C+ P T+ W KD + + N K L I + D G + C AS
Sbjct: 404 VDIGCQAMGVP--LPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFAS 461
Query: 607 TELDQDLAKAYLTVLG----RPDRPRDLELTD 634
E + YL V RP D +TD
Sbjct: 462 NEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTD 493
Score = 35.4 bits (80), Expect = 0.32
Identities = 45/193 (23%), Positives = 72/193 (37%), Gaps = 16/193 (8%)
Query: 22 GGAIEIP--MDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF--N 77
GG I+ +D+T + Q D V ++ CE G P P+ W R +
Sbjct: 464 GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASG 523
Query: 78 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLW 136
+ PR + G + + G Y C+A N G+ S + + S +
Sbjct: 524 SVRIPRFMLLESGGLQIAPVFI-----QDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
Query: 137 PKENLDPVVVQEGAPLTLQCNP--PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
P E D VV+ +G TL C P + ++ + + R+ +G L S
Sbjct: 579 PPE--DHVVI-KGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLIS 635
Query: 195 NVMLQDMQTDYSC 207
D+ DYSC
Sbjct: 636 QTWSGDI-GDYSC 647
Score = 34.7 bits (78), Expect = 0.55
Identities = 30/111 (27%), Positives = 44/111 (39%), Gaps = 6/111 (5%)
Query: 927 VPSAPRRFRVRQPNLE---TINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSP 983
+P +P+ V PN + L W P N ++ Y ++ N K + N P
Sbjct: 667 LPHSPQNLLV-SPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSP--WKVHLSNVGP 723
Query: 984 NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTN 1034
T TV P Y+F + A +VG G+ E S E P+A N
Sbjct: 724 EMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKN 774
>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
Length = 698
Score = 264 bits (675), Expect = 3e-70
Identities = 187/603 (31%), Positives = 285/603 (47%), Gaps = 39/603 (6%)
Query: 369 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 428
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG +
Sbjct: 9 CKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 65
Query: 429 LANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
+NA +SV+ V P R L R L++V ++C SP P W K G+ +
Sbjct: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKE 122
Query: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
+ E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVT 182
Query: 546 RGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERD 597
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 183 VGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKH 242
Query: 598 QGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDY 657
G Y C+ T +D+ A A L V G P P + + ++ + + +L+W PG N+SPIT Y
Sbjct: 243 AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMY 302
Query: 658 VVQFEEDQFQPGVWHDHSKYPGSVN-----SAVLRLSPYVNYQFRVIAINEVGSSHPSLP 712
V+Q F G W S P ++ + V+ L+P+V Y+FR +A N +G PS P
Sbjct: 303 VIQ-ARTPFSVG-WQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRP 360
Query: 713 SERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAW 772
SE+ RT A PE P +V G G K+ + ITW + G Y+V + R + W
Sbjct: 361 SEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAF-RPYGKMIW 419
Query: 773 NNVTVW----GSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPT 826
+TV SRYV V + P+E++V N+ G+GP + + YS E+ P P
Sbjct: 420 -MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 478
Query: 827 EVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDR 886
+ R +++T I + W +G+++ Y YWR +N ++ G++
Sbjct: 479 SIFARSLSATDIEVFWASPLEKN-RGRIQGYEVKYWRHEDKEEN------ARKIRTVGNQ 531
Query: 887 LRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINL 946
++ L Y L + N G GP S T TT + PS P + + I L
Sbjct: 532 TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 591
Query: 947 EWD 949
WD
Sbjct: 592 NWD 594
Score = 85.9 bits (211), Expect = 2e-16
Identities = 150/688 (21%), Positives = 252/688 (36%), Gaps = 86/688 (12%)
Query: 278 ECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 336
EC A+G P P W K G L + D+ + E L IT V+ D+G Y CLA NK G I
Sbjct: 8 ECKANGRPKPTYKWLKNGEPLLTRDRIQIEQ--GTLNITIVNLSDAGMYQCLAENKHGVI 65
Query: 337 RHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 393
+ V A + ++ G + + C+ +PKP W G +
Sbjct: 66 FSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWK-KGRDILKENE 124
Query: 394 NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRV 453
G+ I T+ S Y C +N G + + V D P R++ P + + V
Sbjct: 125 RITISEDGNLRIINVTK-SDAGSYTCIATNHFGTASSTGNLVVKD-PTRVMVPPSSM-DV 181
Query: 454 ILYNRTRLDCPFF--GSPIPTLRWFKNGQGSNLDGGNYHVY------ENGSLEIKMIRKE 505
+ L C S W NG + D H G L I+ I+ +
Sbjct: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241
Query: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE----DQVARRGTTVQLECRVKHDPS 561
G Y C+ + + L V+ P PE D++ TT QL R D
Sbjct: 242 HAGKYVCMVQTSVDRLSAAADLIVRGPP---GPPEAVTIDEIT--DTTAQLSWRPGPDNH 296
Query: 562 LKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV- 620
+T+ ++ P +G + + V E G L+ + + TV
Sbjct: 297 SPITMYVIQARTPFSVGWQ--------AVSTVPELIDGKTFTATVVGLNPWVEYEFRTVA 348
Query: 621 -----LGRPDRPRDLELTDLA---------------ERSVRLTW--IPGDANNSPITDYV 658
+G P RP + T+ A + + +TW +P + N YV
Sbjct: 349 ANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYV 408
Query: 659 VQFEEDQFQPGVWHDHSKYPGSVNSAVLR---LSPYVNYQFRVIAINEVGSSHPSLPSER 715
V F + +W + V R + P+ ++ +V N G P P+
Sbjct: 409 VAFR--PYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTV 465
Query: 716 YRTSGAPPESNPGDVKGEGTRKNNMEITW-TPM--NATSAFGPNLRYIVKWRRRETREAW 772
++ P P + ++E+ W +P+ N G ++Y WR + E
Sbjct: 466 VYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKY---WRHEDKEENA 522
Query: 773 NNVTVWGSRYVVGQTPV--YVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKV 830
+ G++ T + V Y + V+A N G GP +V + + P P + +
Sbjct: 523 RKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNI-I 581
Query: 831 RVMNSTAISLQWNRVYSDTVQGQLREYRAYY-WRESSLLKNLWVSQKRQQASFPGDRLRG 889
+ + I L W++V + + +++ Y+ Y W S + ++ + S P D
Sbjct: 582 WNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFD---- 637
Query: 890 VVSRLFPYSNYKLEMVVVNGRGDGPRSE 917
+Y +E+ + GDG SE
Sbjct: 638 --------EDYIIEIKPFSDGGDGSSSE 657
Score = 63.9 bits (154), Expect = 8e-10
Identities = 72/308 (23%), Positives = 119/308 (38%), Gaps = 51/308 (16%)
Query: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
+N+ EC+A G P P++ W +N + R+ + + + + I S G Y
Sbjct: 3 ENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLSDA------GMY 54
Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNPPPGLPSPVIFW 169
QC A NK G SN ++ P + + L V +V+ G + ++C P P PV W
Sbjct: 55 QCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTW 113
Query: 170 MSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT 229
+ + +++R++ +G+L NV D + Y+C + T
Sbjct: 114 -KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTC-------------------IAT 152
Query: 230 NHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
NH SS N V + M P SS V G ++L C + + DI
Sbjct: 153 NHFGTASSTGNL--------VVKDPTRVMVP---PSSMDVTVGESIVLPCQVTHDHSLDI 201
Query: 290 --AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTI 340
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 202 VFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA 261
Query: 341 SVRVKAAP 348
+ V+ P
Sbjct: 262 DLIVRGPP 269
Score = 53.9 bits (128), Expect = 9e-07
Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYF 326
+V G ++++EC P P W KKG D+ + + + + LRI NV++ D+G Y
Sbjct: 90 LVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGSYT 148
Query: 327 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV--QWMVN 384
C+A+N G+ T ++ VK + P ++ + GE L C+ + + W N
Sbjct: 149 CIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFN 208
Query: 385 GEPLQSAPPNPN------REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 438
G + + ++ AGD +I R+ Q+ Y C L A A + V
Sbjct: 209 GHLIDFDRDGDHFERVGGQDSAGDLMI-RNIQLKHAGKYVCMVQTSVDRLSAAADLIVRG 267
Query: 439 VP 440
P
Sbjct: 268 PP 269
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 239 bits (611), Expect = 9e-63
Identities = 245/1007 (24%), Positives = 398/1007 (39%), Gaps = 82/1007 (8%)
Query: 51 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
+ +++ C A+G+ F W N+R + S+ R +D + G Y
Sbjct: 42 NRLVLTCMAEGSWPLEFKWLHNNRELT-----KFSLEYRYMITSLD-------RTHAGFY 89
Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170
+C RN+ G L + +QV+ + +E V G ++ P P + W
Sbjct: 90 RCIVRNRMGALLQRQTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWF 148
Query: 171 SSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKN-------PF 223
+ I R++ L + + D A ++ + KN P
Sbjct: 149 RDGRK-IPPSSRIAITLENTLVILSTVAPD--------AGRYYVQAVNDKNGDNKTSQPI 199
Query: 224 TLKVLTNHPYNDSSLRNHPDMYSARGVAER-TPSFMYPQGTASSQMVLRGMDLLLECIAS 282
TL V + G A+ P+ + P S +V ++ LEC+A+
Sbjct: 200 TLTV-----------------ENVGGPADPIAPTIIIPPKNTS--VVAGTSEVTLECVAN 240
Query: 283 GVPTPD--IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC---LASNKMGSIR 337
P I W KK G L S + N+ L I N + D+G Y C L S+ + S+
Sbjct: 241 ARPLIKLHIIW-KKDGVLLS--GGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVV 297
Query: 338 HTISVRVKAAPYWLDEPKNLILAPGEDG-RLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 396
+ V P ++ EP+ I A E + C+A G P P++ W + ++
Sbjct: 298 RGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRF 357
Query: 397 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 456
R+ + ++QC N G + + +++V + P + R L ++
Sbjct: 358 RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT--RGPLDSTVID 415
Query: 457 NRTR-LDCPFFGSPIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 512
+ L C G+P P + W K + ++ + E+GSL I D G YTC
Sbjct: 416 GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475
Query: 513 VATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 572
+ATN G E L V TRI + P+DQ +GT + C V HDP + + W KD
Sbjct: 476 LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG 535
Query: 573 EPLYIGNRMK---KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRD 629
L + + + SL I D G+YTC + D A+L V P P
Sbjct: 536 ATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH 595
Query: 630 --LELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLR 687
L+ + R++ LTW NSP+ Y+++ E+ P S P + + V
Sbjct: 596 PVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENN-APWTVLLASVDPKATSVTVKG 654
Query: 688 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPM 747
L P +YQFR+ A+N+VG S +ER PP + P +V G ++ I W P
Sbjct: 655 LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPP 714
Query: 748 NATSAFGPNLRYIVKW--RRRETREAWNNVT-VWGSRYVVGQTPVYVPYEIRVQAENDFG 804
+ G YI+++ + N+T + ++ ++ YEI V A N G
Sbjct: 715 PESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAG 774
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
G V ++ + P P V NST I WN + G + Y+ W
Sbjct: 775 LGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEP 834
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
+ V+ + +F G VS L ++ Y ++ GDGPRS + T
Sbjct: 835 E---QEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTH 891
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPN 984
E VP + ++ + W P NGI+ GY + + +N T V ++ PN
Sbjct: 892 EDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTR---VTHYLPN 948
Query: 985 QT-KFTVQRTDPVSRYRFTLSARTQVGSGE--AVTEESPAPPNEATP 1028
T ++ V ++ Y ++A T G G+ A T S PP P
Sbjct: 949 VTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP 995
Score = 140 bits (352), Expect = 9e-33
Identities = 109/420 (25%), Positives = 188/420 (44%), Gaps = 27/420 (6%)
Query: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGV-W---HDHSKYPG 679
P P +L ++++ RSV L + PG + I+ ++V+ + G W H S P
Sbjct: 993 PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052
Query: 680 SVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNN 739
+ + V L+P+ Y FR+ +N VG+S PS PS + +T APP+ P +V + +
Sbjct: 1053 ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETS 1112
Query: 740 MEITWTPMNATSAFG--PNLRYIVKWRRRETREAWNNVTVWG---SRYVVGQTPVYVPYE 794
+ + W P+ G ++ Y +K+ R + + V Y + + Y
Sbjct: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYR 1172
Query: 795 IRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQL 854
++VQA N G GP ++V+G + E P + PT V S+++ ++W+ V G +
Sbjct: 1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLV 1232
Query: 855 REYRAYY-WRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDG 913
Y+ Y ++S W+ + S ++ L Y Y+++++ GDG
Sbjct: 1233 LGYKVMYKEKDSDTQPRFWLVEGNSSRS-------AQLTGLGKYVLYEVQVLAFTRIGDG 1285
Query: 914 PRSETKEF-TTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTK 972
S T + VP P + ++ L W P PNGI++ Y + + N T
Sbjct: 1286 SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITH-RLNTTT 1344
Query: 973 VGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEA-----VTEES---PAPPN 1024
VE +P+ ++T P S Y F ++A+T+ G GEA VT E P PP+
Sbjct: 1345 ANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPS 1404
Score = 138 bits (348), Expect = 3e-32
Identities = 119/457 (26%), Positives = 189/457 (41%), Gaps = 56/457 (12%)
Query: 612 DLAKAYLTVLGRPDRPRD-----LELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQF 666
+ A+A + + DRP+ ++ D+ RSV L+W PG SP+ Y +Q E
Sbjct: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRE--L 1442
Query: 667 QPGVWHDHSKYPGSVNSAVL--RLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPE 724
G W HS S+ + RL P+ +Y+FRV A N++G S S SE T A P+
Sbjct: 1443 PSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
Query: 725 SNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR-------RRETREAWNNV-T 776
P + ++ I W P G L + +++R R T NN
Sbjct: 1503 EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGA 1562
Query: 777 VWG----------------SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDY 820
W ++Y + + YEIR+ N G+GP + GE
Sbjct: 1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV 1622
Query: 821 PRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE-----SSLLKNLWVSQ 875
P AAP V V +T + + W D+ G ++ Y+ Y+W + +K L++++
Sbjct: 1623 PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
Query: 876 KRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFR 935
+ + L Y+ Y + + N GDGPRS + T + PSAP +
Sbjct: 1683 NSVK-----------LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVK 1731
Query: 936 VRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNG----TKVGKQIVENFSPNQTKFTVQ 991
+ ++N+ W+ P+ PNGI+ GY L Y + +K+ V+ SP K V+
Sbjct: 1732 FSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLK--VK 1789
Query: 992 RTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATP 1028
YRF + A+T G + P E P
Sbjct: 1790 DLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGEGAP 1825
Score = 67.0 bits (162), Expect = 1e-10
Identities = 78/334 (23%), Positives = 127/334 (38%), Gaps = 47/334 (14%)
Query: 29 MDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRR 88
+ + +PP K+ + + + I C+AKG P PS W +++ + K R R
Sbjct: 302 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 361
Query: 89 RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQE 148
G + SG P++ G +QCFARN G ++ S +P + LD V+ +
Sbjct: 362 DGGLQI----SGLVPDD-TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI-D 415
Query: 149 GAPLTLQCNPPPGLPSPVIFWMSSS---MEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205
G + L C G P P I W Q R + +G L S + D T Y
Sbjct: 416 GMSVVLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGT-Y 473
Query: 206 SCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTAS 265
+C A ++ R + + V RT PQ
Sbjct: 474 TCLA--------------------------TNSRGVDEASADLVVWARTRITKPPQ---- 503
Query: 266 SQMVLRGMDLLLECIASGVPTPDI--AWYKKGGDLPSD---KAKFENFNKALRITNVSEE 320
Q V++G + C + P I W K G L ++ + + + N +L I+
Sbjct: 504 DQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDR-NGSLHISQTWSG 562
Query: 321 DSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
D G Y C + G+ + +RV+ P+ + P
Sbjct: 563 DIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHP 596
Score = 64.7 bits (156), Expect = 5e-10
Identities = 82/375 (21%), Positives = 136/375 (36%), Gaps = 32/375 (8%)
Query: 266 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEY 325
+Q+ L G L+L C+A G + W +L ++ IT++ +G Y
Sbjct: 35 TQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYM-----ITSLDRTHAGFY 89
Query: 326 FCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRL-VCRANGNPKPTVQWMV 383
C+ N+MG+ ++ V+V + + K+ ++ GE + R P+P V W
Sbjct: 90 RCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFR 149
Query: 384 NGEPLQSAPPNPNREVA-GDTIIFRDTQISSRAVYQCNTSNEHG----------YLLANA 432
+G + PP+ + +T++ T Y N+ + N
Sbjct: 150 DGRKI---PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENV 206
Query: 433 FVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY 492
+ P ++ P V + L+C P+ L G L GG
Sbjct: 207 GGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISD-- 264
Query: 493 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR---LEVKDPTRIYRMPEDQV-ARRGT 548
N L I D G Y C A + VR L V +P + + PE + A
Sbjct: 265 HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEK 324
Query: 549 TVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK---KEDDSLTIFGVAERDQGSYTCVA 605
V + C+ K P +T W KD + + + + D L I G+ D G + C A
Sbjct: 325 VVDIPCQAKGVPPPSIT--WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA 382
Query: 606 STELDQDLAKAYLTV 620
+ YL V
Sbjct: 383 RNAAGEVQTSTYLAV 397
Score = 58.9 bits (141), Expect = 3e-08
Identities = 90/427 (21%), Positives = 163/427 (38%), Gaps = 23/427 (5%)
Query: 619 TVLGRPDR-PRDLELTDLAERSVRLTWIP---GDANNSPIT-DYVVQFEEDQFQPGVWHD 673
T+ PD P ++ L +E S+ L W+P + N +P + Y +++
Sbjct: 1091 TLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSH 1150
Query: 674 HSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGE 733
+ + + L + Y+ +V A N +GS P + RT + P S P +V
Sbjct: 1151 VVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSAL 1209
Query: 734 GTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTP---VY 790
T ++M + W+ + G L Y V ++ +++ V G+ Q Y
Sbjct: 1210 ATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKY 1269
Query: 791 VPYEIRVQAENDFGKG-PEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDT 849
V YE++V A G G P ++ + +D P P + + +T++ L W +
Sbjct: 1270 VLYEVQVLAFTRIGDGSPSHPPILERTLDDVP-GPPMGILFPEVRTTSVRLIWQPPAAPN 1328
Query: 850 VQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNG 909
G + Y+ + ++ V A + + L P S Y +
Sbjct: 1329 --GIILAYQITHRLNTTTANTATVEVLAPSAR------QYTATGLKPESVYLFRITAQTR 1380
Query: 910 RGDGPRSETKEFTTPE-GVPSAPRRFRVRQPNLE--TINLEWDHPEHPNGIMIGYTLKYV 966
+G G +E TT + P P R V+Q ++ ++ L W+ + YT++
Sbjct: 1381 KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR 1440
Query: 967 AFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEA 1026
+ + S N + F V R P + Y+F + A +G E E +A
Sbjct: 1441 ELPSGRWALHSA-SVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1499
Query: 1027 TPTAAYT 1033
P A T
Sbjct: 1500 APDEAPT 1506
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/89 (33%), Positives = 42/89 (47%), Gaps = 6/89 (6%)
Query: 639 SVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWH----DHSKYPGSVNSAVLRLSPYVNY 694
++ + W GD PIT YV++ G+W D K S ++ L P V+Y
Sbjct: 1839 AIAIHWSSGDPGKGPITRYVIEARPSD--EGLWDILIKDIPKEVSSYTFSMDILKPGVSY 1896
Query: 695 QFRVIAINEVGSSHPSLPSERYRTSGAPP 723
FRVIA+N+ G PS PS+ A P
Sbjct: 1897 DFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
Score = 38.5 bits (88), Expect = 0.038
Identities = 30/107 (28%), Positives = 42/107 (39%), Gaps = 10/107 (9%)
Query: 944 INLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTL 1003
INL W P N +I Y L+ N ++ + P T TV+ P Y+F L
Sbjct: 608 INLTWTKPFDGNSPLIRYILEMSENNAPWT--VLLASVDPKATSVTVKGLVPARSYQFRL 665
Query: 1004 SARTQVGSGE--------AVTEESPAPPNEATPTAAYTNNQADIATQ 1042
A VG G+ ++ EE P P + + TN I Q
Sbjct: 666 CAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQ 712
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 217 bits (553), Expect = 5e-56
Identities = 260/1034 (25%), Positives = 413/1034 (39%), Gaps = 133/1034 (12%)
Query: 36 TITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVI 95
TI+ + K + + + C G W RN N K+ R++ L++
Sbjct: 317 TISPRKVKSSV---GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHEN-LIM 372
Query: 96 DF--RSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK--ENLDPVVVQEGAP 151
D +S G G YQCF R LS + +QV PK VV P
Sbjct: 373 DHMVKSDG------GAYQCFVRKD---KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEP 423
Query: 152 LTLQCNPPPGLPSPVIFWMSSSMEPITQ--DKRVSQ---GHNGDLYFSNVMLQDMQTD-- 204
++L CN G P P I W +PI + R+SQ + + N+ ++
Sbjct: 424 VSLMCNVK-GTPLPTITWTLDD-DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGV 481
Query: 205 YSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTA 264
Y C A N + + +Y AR + R P+ + P
Sbjct: 482 YRCTAN-----------------------NSAGVV----LYQAR-INVRGPASIRPMKNI 513
Query: 265 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD--KAKFENFNKALRITNVSEE-D 321
++ + G D + C G P I WYK LP + + FEN N L++++V +E D
Sbjct: 514 TA---IAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN-NGTLKLSDVQKEVD 569
Query: 322 SGEYFC-LASNKMGSIRHTISVRVKAAPYW--LDEPKNLILAPGEDGRLVCRANGNPKP- 377
GEY C + S ++ V VK P+ + P+ I G+ + C P
Sbjct: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI---GQRVFIPCVVVSGDLPI 626
Query: 378 TVQWMVNGEPLQSAPPNPNREVAGDTIIFRDT-QISSRAV-----YQCNTSNEHGYLLAN 431
T+ W +G P+ + V D I F + +IS+ ++ Y C NE +
Sbjct: 627 TITWQKDGRPIPGS-----LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681
Query: 432 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD------ 485
+ + V P ++ PR+Q I L+C G P+PT+ W K +G+ +
Sbjct: 682 SQLIVRVPPKFVVQPRDQ--DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIA 738
Query: 486 -GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK-AENQVRLEVKDPTRIYRMPEDQV 543
G V NGSL IK + +ED G Y C +N +G + L VK P I P +
Sbjct: 739 LNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL 798
Query: 544 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL------YIGNRMKKEDD---SLTIFGVA 594
A +G ++ C + + V W K+D + Y+ + + ++ +L I
Sbjct: 799 ATQGQKKEMSCTAHGEKPI--IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
Query: 595 ERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPI 654
D G ++C A +D LTV PD P ++E+ D+ R++ L W G NSPI
Sbjct: 857 REDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFDGNSPI 915
Query: 655 TDYVVQFEEDQFQPGVWHDHSKYPGSVNSA-VLRLSPYVNYQFRVIAINEVGSSHPSLPS 713
T Y ++ + +NSA ++ + P Y R+ A N +G S PS +
Sbjct: 916 TGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--N 973
Query: 714 ERYRTSG-APPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRET--RE 770
E T+ A P+ P +V E ++ +TW G Y + +R T
Sbjct: 974 ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNF 1033
Query: 771 AWNNVTVWGSR----YVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPT 826
+N ++V S Y + + Y + VQA N G GP + +I + ED P P
Sbjct: 1034 QFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPE 1093
Query: 827 EVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWR-----ESSLLKNLWVSQKRQQAS 881
V+ + +IS+ W+ + + + G L+ +R YW E +KN+ +Q
Sbjct: 1094 NVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQ------ 1147
Query: 882 FPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNL 941
P L G L Y+NY ++++ GDG RSE T E VP P + +
Sbjct: 1148 -PSLELDG----LEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASA 1202
Query: 942 ETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE-NFSPNQTKFTVQRTDPVSRYR 1000
+ + W P NGI+ KY F I E SP+ + + +Y
Sbjct: 1203 SMVFVSWLPPLKLNGII----RKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258
Query: 1001 FTLSARTQVGSGEA 1014
+ A T G G +
Sbjct: 1259 VWVVAVTSAGRGNS 1272
Score = 135 bits (341), Expect = 2e-31
Identities = 186/870 (21%), Positives = 329/870 (37%), Gaps = 98/870 (11%)
Query: 19 LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 78
LS +++ ++ P I+ S K +V P + + + C KG P P+ WT +
Sbjct: 392 LSAQDYVQVVLEDGTPKIISAFSEK--VVSPAEPVSLMCNVKGTPLPTITWTLDDDPILK 449
Query: 79 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE-YQCFARNKFGTALSN-RIRLQVSKSPLW 136
R+S S V+ + + + +G Y+C A N G L RI ++ S +
Sbjct: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-IR 508
Query: 137 PKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNV 196
P +N+ + G + C G P I W +S ++V+ +NG L S+V
Sbjct: 509 PMKNITAIA---GRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDV 564
Query: 197 MLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPS 256
+ + +Y+CN + Q T+KV P
Sbjct: 565 QKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV---------------------------PP 597
Query: 257 FMYPQGTASSQMVLRGMDLLLECIASGVPTP-DIAWYKKGGDLPSDKA-KFEN--FNKAL 312
F+ P + G + + C+ P I W K G +P +N F +L
Sbjct: 598 FIQPFEFPRFSI---GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
Query: 313 RITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 372
RI+N+S +G Y C+A N+ ++ H + V+ P ++ +P++ G+ L C A
Sbjct: 655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAE 714
Query: 373 GNPKPTVQWMVN---GEPLQSAPPNPNREV---AGDTIIFRDTQISSRAVYQCNTSNEHG 426
G P PT+ W + G P Q P N + + +++ + Y C SN+ G
Sbjct: 715 GYPVPTIVWKFSKGAGVP-QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG 773
Query: 427 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 486
++ + + +P + S N + + + C G +RW K + N +
Sbjct: 774 ADVSKSMYLTVKIPAMITSYPNTTL-ATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEM 832
Query: 487 GNYHVYEN-------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539
Y V +L+I +ED G ++C A N G+ ++L V++P +
Sbjct: 833 ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE 892
Query: 540 EDQVARRGTTVQ---------------LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 584
V R T++ +EC+ K D SW + ++
Sbjct: 893 IKDVKARTITLRWTMGFDGNSPITGYDIECKNKSD-------SWDSAQRTKDVSPQL--- 942
Query: 585 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL---GRPD-RPRDLELTDLAERSV 640
+S TI + S A + + LT+ PD P+++ L ++ +S+
Sbjct: 943 -NSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI 1001
Query: 641 RLTWIPGDAN--NSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVL---RLSPYVNYQ 695
R+TW + N I Y + + E + S +S V L+ + Y
Sbjct: 1002 RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYG 1061
Query: 696 FRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGP 755
V A N G+ PS T P P +V+ T ++ I+W+ ++ + G
Sbjct: 1062 LVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGI 1120
Query: 756 NLRY-IVKWRRRETREAW--NNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESV 812
+ ++ W E N+T + Y Y I+V A G G E +
Sbjct: 1121 LQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQI 1180
Query: 813 IGYSGEDYPRAAPTEVKVRVMNSTAISLQW 842
+ ED P P VK +++ + + W
Sbjct: 1181 FTRTKEDVP-GPPAGVKAAAASASMVFVSW 1209
Score = 113 bits (282), Expect = 1e-24
Identities = 135/573 (23%), Positives = 220/573 (38%), Gaps = 63/573 (10%)
Query: 54 LIECEAKGNPAPSFHW--TRNSRFFNIAKDPRVSMRRRSGTL-VIDFR-SGGRPEEYEGE 109
L+ C A G P + W +++ P + +GTL + F S ++
Sbjct: 43 LVPCPAAGIPPVTLRWYLATGEEIYDV---PGIRHVHPNGTLQIFPFPPSSFSTLIHDNT 99
Query: 110 YQCFARNKFGTALSNRIRLQ-VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS--PV 166
Y C A N G S + ++ V + P + ++ G +C P + + V
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVR--VEDQKTMRGNVAVFKCIIPSSVEAYITV 157
Query: 167 IFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 226
+ W ++ + R G LY +V +D +Y C R +T +Q N + +
Sbjct: 158 VSWEKDTVS-LVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSN--SAR 214
Query: 227 VLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 286
+ + P N + PS + + + G + L C A G P
Sbjct: 215 LFVSDPANSA------------------PSIL---DGFDHRKAMAGQRVELPCKALGHPE 253
Query: 287 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
PD W K L +F+ L I N+ DSG Y C SN+ G+ + + VK
Sbjct: 254 PDYRWLKDNMPLELS-GRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQ 312
Query: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG---DT 403
P+ + + G L C G + W NGE L P N + G +
Sbjct: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN---PGKNVRITGINHEN 369
Query: 404 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL--DVPPRMLSPRNQLIRVILYNRTRL 461
+I S YQC + L A +V V+ D P+++S ++ + V L
Sbjct: 370 LIMDHMVKSDGGAYQCFVRKDK--LSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSL 426
Query: 462 DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN--------GSLEIKMIRKEDQGIYTCV 513
C G+P+PT+ W + L GG++ + + L I + D G+Y C
Sbjct: 427 MCNVKGTPLPTITWTLD-DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
Query: 514 ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 573
A N G Q R+ V+ P I R ++ A G + CRV P ++ W K+
Sbjct: 486 ANNSAGVVLYQARINVRGPASI-RPMKNITAIAGRDTYIHCRVIGYP--YYSIKWYKNSN 542
Query: 574 PLYIGNRMK--KEDDSLTIFGV-AERDQGSYTC 603
L +R + + +L + V E D+G YTC
Sbjct: 543 LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
Score = 66.6 bits (161), Expect = 1e-10
Identities = 58/200 (29%), Positives = 82/200 (41%), Gaps = 11/200 (5%)
Query: 530 KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYI---GNRMKKE 584
K P RI + L C+ DPS V W+KD P + G R
Sbjct: 1283 KAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP--AVKWMKDSNGTPSLVTIDGRRSIFS 1340
Query: 585 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTW 644
+ S I V D G Y+C+A+ D L V PD+PR L ++ S+ L+W
Sbjct: 1341 NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSW 1399
Query: 645 IPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEV 704
+PGD S I Y++Q+ ED + W P + + L Y+F + A N V
Sbjct: 1400 LPGDNGGSSIRGYILQYSEDNSEQ--WGSFPISPSERSYRLENLKCGTWYKFTLTAQNGV 1457
Query: 705 GSSHPSLPSERYRTSGAPPE 724
G S E +T G P+
Sbjct: 1458 GPGRISEIIEA-KTLGKEPQ 1476
Score = 60.1 bits (144), Expect = 1e-08
Identities = 75/303 (24%), Positives = 119/303 (39%), Gaps = 34/303 (11%)
Query: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLV-CRANGNPKPTVQW-MVNG 385
LA + S + S + ++ Y+++ ++ G LV C A G P T++W + G
Sbjct: 4 LALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATG 63
Query: 386 EPLQSAPPNPNREVAGDTIIFRDTQISSRAV-----YQCNTSNEHGYLLANAFVSVLDVP 440
E + P + G IF S + Y C N G + + DV
Sbjct: 64 EEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQ------DVH 117
Query: 441 PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPT--------LRWFKNGQGSNLDGGNYHVY 492
+ + +RV R + F IP+ + W K+ S + G + +
Sbjct: 118 IKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTV-SLVSGSRFLIT 176
Query: 493 ENGSLEIKMIRKEDQGIYT--CVATNILG---KAENQVRLEVKDPTR----IYRMPEDQV 543
G+L IK ++ ED G+Y C+ + + N RL V DP I + +
Sbjct: 177 STGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRK 235
Query: 544 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 603
A G V+L C+ P + WLKD+ PL + R +K L I + D GSY C
Sbjct: 236 AMAGQRVELPCKALGHP--EPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVC 293
Query: 604 VAS 606
S
Sbjct: 294 EVS 296
Score = 55.1 bits (131), Expect = 4e-07
Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 21/116 (18%)
Query: 461 LDCPFFGSPIPTLRWFKNGQGS----NLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
L C G P P ++W K+ G+ +DG ++ NGS I+ ++ ED G Y+C+A N
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRR-SIFSNGSFIIRTVKAEDSGYYSCIANN 1363
Query: 517 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 572
G E + L+V ++P DQ V S +T+SWL D
Sbjct: 1364 NWGSDEIILNLQV-------QVPPDQP---------RLTVSKTTSSSITLSWLPGD 1403
Score = 49.3 bits (116), Expect = 2e-05
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 7/86 (8%)
Query: 274 DLLLECIASGVPTPDIAWYKKGGDLPS----DKAKFENFNKALRITNVSEEDSGEYFCLA 329
D++L C A G P+P + W K PS D + N + I V EDSG Y C+A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 330 SNKMGSIRHTISVRVKAAPYWLDEPK 355
+N GS ++++V+ P D+P+
Sbjct: 1362 NNNWGSDEIILNLQVQVPP---DQPR 1384
Score = 35.4 bits (80), Expect = 0.32
Identities = 25/103 (24%), Positives = 39/103 (37%), Gaps = 8/103 (7%)
Query: 928 PSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTK 987
P P ++ TI L W N + GY ++ + + Q ++ SP
Sbjct: 885 PPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944
Query: 988 FTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTA 1030
T+ P S Y + A+ ++G E P NE T TA
Sbjct: 945 ATIIDIHPSSTYSIRMYAKNRIGKSE--------PSNELTITA 979
Score = 35.4 bits (80), Expect = 0.32
Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 927 VPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 986
VP R V + +I L W ++ + GY L+Y N + G + SP++
Sbjct: 1378 VPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPI---SPSER 1434
Query: 987 KFTVQRTDPVSRYRFTLSARTQVGSG 1012
+ ++ + Y+FTL+A+ VG G
Sbjct: 1435 SYRLENLKCGTWYKFTLTAQNGVGPG 1460
Score = 34.3 bits (77), Expect = 0.72
Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 4/81 (4%)
Query: 367 LVCRANGNPKPTVQWM--VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE 424
L C+A G+P P V+WM NG P + + I R + Y C +N
Sbjct: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNN 1364
Query: 425 HG--YLLANAFVSVLDVPPRM 443
G ++ N V V PR+
Sbjct: 1365 WGSDEIILNLQVQVPPDQPRL 1385
Score = 32.3 bits (72), Expect = 2.7
Identities = 29/110 (26%), Positives = 48/110 (43%), Gaps = 16/110 (14%)
Query: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN--IAKDPRVSMRR 88
LT T+T KD I++ C+A G+P+P+ W ++S + D R S+
Sbjct: 1289 LTFSGTVTTPWMKD--------IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFS 1340
Query: 89 RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 138
++ ++ E G Y C A N +G+ + LQV P P+
Sbjct: 1341 NGSFIIRTVKA-----EDSGYYSCIANNNWGSD-EIILNLQVQVPPDQPR 1384
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 214 bits (545), Expect = 4e-55
Identities = 205/796 (25%), Positives = 341/796 (42%), Gaps = 65/796 (8%)
Query: 270 LRGMDLLLECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNV-----SEEDS 322
+RG ++L C A P+P I W K G +L SD + + +L I+NV ++ D
Sbjct: 65 VRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDE 124
Query: 323 GEYFCLAS-NKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQ 380
G Y C+A+ +G+I T + V P + +P+ + G + L C N + P V+
Sbjct: 125 GYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVR 184
Query: 381 WMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 440
W N +PL + +G +I T+ +Y+C + ++ +
Sbjct: 185 WEQNRQPLL-LDDRVIKLPSGMLVISNATE-GDGGLYRCVVESGGPPKYSDEVELKVLPD 242
Query: 441 PRMLSPR------NQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY-E 493
P ++S + L+RVI + L C G P PT++W KN + + + V
Sbjct: 243 PEVISDLVFLKQPSPLVRVIGQDVV-LPCVASGLPTPTIKWMKNEEALDTESSERLVLLA 301
Query: 494 NGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLE 553
GSLEI + ++D G Y C+A N E Q L V+ + P + A + E
Sbjct: 302 GGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFE 361
Query: 554 CRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KEDDSLTIFGVAERDQGSYTCVASTELDQD 612
C V P+ TV W+K+ + + + K ++ +L + G+ + D+G Y C+A ++
Sbjct: 362 CEVTGKPTP--TVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNA 419
Query: 613 LAKAYLTVLGR--------PDRPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFE 662
A A L +L P PRD+ + ++ R ++LTW D + +T V +
Sbjct: 420 QAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
Query: 663 EDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAP 722
E + V +++ +PG + + L P Y FRV+A N+ GS S P R P
Sbjct: 480 EGIARERV--ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAP---LRVETQP 534
Query: 723 PESNPG---DVKGEGTRKNNMEITW-TPMNATSAF-GPNLRYIVKWRRRETREAWNNVTV 777
PG +++ ++ +TW TP++ L Y+ K +E +V V
Sbjct: 535 EVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKE-----QDVDV 589
Query: 778 WGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 837
Y + Y Y RV A N G G V + D P AAP + + V NS +
Sbjct: 590 SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
Query: 838 ISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPY 897
I + W T GQ+ Y+ Y R++S ++ + G +L ++ L
Sbjct: 650 IMIHWQPPAPATQNGQITGYKIRY-RKASRKSDV------TETLVSGTQLSQLIEGLDRG 702
Query: 898 SNYKLEMVVVNGRGDGPRSETKEFTTPEG------VPSAPRRFRVRQPNLETINLEWDHP 951
+ Y + + G GP ++ T E VP P VR P + +I + W P
Sbjct: 703 TEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR-PLVTSIVVSWTPP 761
Query: 952 EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGS 1011
E+ N ++ GY + Y G+ + I ++ Q +T++ DP S Y TL A VG
Sbjct: 762 ENQNIVVRGYAIGYGI--GSPHAQTIKVDYK--QRYYTIENLDPSSHYVITLKAFNNVGE 817
Query: 1012 GEAVTEESPAPPNEAT 1027
G + E + P+ T
Sbjct: 818 GIPLYESAVTRPHTDT 833
Score = 163 bits (413), Expect = 8e-40
Identities = 248/1100 (22%), Positives = 424/1100 (38%), Gaps = 146/1100 (13%)
Query: 6 PPPWVHAAFLLCLLSLGGAIEIPMDLTQPP--TITKQSAKDHIVDPRD-------NILIE 56
P W++ LL + G A Q P +I + +V+P D ++++
Sbjct: 14 PSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILN 73
Query: 57 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR- 115
C A P+P W ++ F N+ D R + + + + EG YQC A
Sbjct: 74 CSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATV 133
Query: 116 NKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME 175
GT +S +L V+ P + + +P V G L C L P + W + +
Sbjct: 134 ESLGTIISRTAKLIVAGLPRFTSQP-EPSSVYAGNNAILNCEVNADL-VPFVRW-EQNRQ 190
Query: 176 PITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYND 235
P+ D RV + +G L SN D Y C ++ P Y+D
Sbjct: 191 PLLLDDRVIKLPSGMLVISNATEGDGGL-YRC--------VVESGGP--------PKYSD 233
Query: 236 S-SLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK- 293
L+ PD E ++ + + V+ G D++L C+ASG+PTP I W K
Sbjct: 234 EVELKVLPD-------PEVISDLVFLKQPSPLVRVI-GQDVVLPCVASGLPTPTIKWMKN 285
Query: 294 -KGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD 352
+ D S + +L I++V+E+D+G YFC+A N +I + V+A P +L
Sbjct: 286 EEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLK 345
Query: 353 EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 412
+P N+ D C G P PTV+W+ NG+ + P + + V + S
Sbjct: 346 QPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMV--IPSDYFKIVKEHNLQVLGLVKS 403
Query: 413 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYN-----------RTRL 461
YQC N+ G A A + +L+ P P R ++ + RT
Sbjct: 404 DEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPA 463
Query: 462 DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 521
P + ++ + K G H E + I+ + I+ +A N G
Sbjct: 464 SDPHGDNLTYSVFYTKEGIARERVENTSHPGEM-QVTIQNLMPATVYIFRVMAQNKHGSG 522
Query: 522 ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW---------LKDD 572
E+ P R+ PE Q+ G L S +TV+W +++
Sbjct: 523 ESSA------PLRVETQPEVQLP--GPAPNLRAYAASPTS--ITVTWETPVSGNGEIQNY 572
Query: 573 EPLYIGNRMKKEDD------SLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPD- 625
+ Y+ KE D S TI G+ + + S+ VA + ++ + V D
Sbjct: 573 KLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDV 632
Query: 626 ---RPRDLELTDLAERSVRLTWIP--GDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGS 680
P++L L +S+ + W P N IT Y +++ + + V + G+
Sbjct: 633 PSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDV--TETLVSGT 690
Query: 681 VNSAVLR-LSPYVNYQFRVIA--INEVGSSHPSLPSERYRT----SGAPPESNPGDVKGE 733
S ++ L Y FRV A IN G + L +E + + + P + V+
Sbjct: 691 QLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPL 750
Query: 734 GTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPY 793
T ++ ++WTP + Y + + V Y + Y
Sbjct: 751 VT---SIVVSWTPPENQNIVVRG--YAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHY 805
Query: 794 EIRVQAENDFGKG-PEPESVIGYSGEDYPRAAPTEVKVRVMNS------------TAISL 840
I ++A N+ G+G P ES + P +EV + V+N+ + +
Sbjct: 806 VITLKAFNNVGEGIPLYESAV-----TRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGV 860
Query: 841 QWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQ-----QASFPGD---------R 886
Q + + DT++ W ++SL K+ ++ R + + P +
Sbjct: 861 QASILSHDTIR--------ITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912
Query: 887 LRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRR---FRVRQPNLET 943
L +V+ L P + Y+ ++V GR S T TT E VP++P + ++ +T
Sbjct: 913 LSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKT 972
Query: 944 INLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTL 1003
I + W P NG + GY + Y ++ ++E N+ +Q + Y F +
Sbjct: 973 IIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKI 1032
Query: 1004 SARTQVGSG---EAVTEESP 1020
AR G G EAV +P
Sbjct: 1033 QARNSKGMGPMSEAVQFRTP 1052
Score = 40.0 bits (92), Expect = 0.013
Identities = 66/329 (20%), Positives = 111/329 (33%), Gaps = 41/329 (12%)
Query: 624 PDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSK-----YP 678
P+ P L + L S+ ++W P + N + Y + + G+ H++ Y
Sbjct: 739 PEVPSSLHVRPLVT-SIVVSWTPPENQNIVVRGYAIGY-------GIGSPHAQTIKVDYK 790
Query: 679 GSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS-----------GAP----- 722
+ + L P +Y + A N VG P S R AP
Sbjct: 791 QRYYT-IENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVP 849
Query: 723 ---PESNPGDVKGEGTRKNNMEITWTPMNATS--AFGPNLRYIVKWRRR-ETREAWNNVT 776
P P V+ + + ITW + + Y V+W+ + N
Sbjct: 850 DPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNAN 909
Query: 777 VWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNST 836
Y+V YE V + G + E P + P +V V
Sbjct: 910 ATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGK 969
Query: 837 AISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFP 896
++ N G++ Y YY + + + WV + G+RL + L
Sbjct: 970 PKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEP-----VVGNRLTHQIQELTL 1024
Query: 897 YSNYKLEMVVVNGRGDGPRSETKEFTTPE 925
+ Y ++ N +G GP SE +F TP+
Sbjct: 1025 DTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 209 bits (531), Expect = 2e-53
Identities = 251/1047 (23%), Positives = 410/1047 (39%), Gaps = 132/1047 (12%)
Query: 36 TITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSG-TLV 94
T+T + K I +++ C G+P + W RN+ + D +S+R S TL+
Sbjct: 378 TLTPKKLKTGI---GSTVILSCALTGSPEFTIRWYRNTEL--VLPDEAISIRGLSNETLL 432
Query: 95 IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTL 154
I + + G YQCFA K TA I +P + VV G +L
Sbjct: 433 IT----SAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVS-SFSEKVVNPGEQFSL 487
Query: 155 QCNPPPGLPSPVIFWMSSSMEPITQD--KRVSQGHNGD---LYFSNVMLQDMQTD--YSC 207
C G P P + W EPI +D R +Q D + NV ++ Y C
Sbjct: 488 MC-AAKGAPPPTVTWALDD-EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRC 545
Query: 208 NARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQ 267
AR + + ++ ++R P + + R +
Sbjct: 546 TAR-----NLVGSAEYQARI---------NVRGPPSIRAMRNIT---------------- 575
Query: 268 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYF 326
+ G D L+ C G P I WYK LP + + N L++T+V + D GEY
Sbjct: 576 -AVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYL 634
Query: 327 C-LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLV---CRANGNPKPT-VQW 381
C + SI ++ V VK P L +P P G+L+ C + P + W
Sbjct: 635 CSVLIQPQLSISQSVHVAVKVPP--LIQPFEF--PPASIGQLLYIPCVVSSGDMPIRITW 690
Query: 382 MVNGEPLQSAPPNPNREVAGDTIIFRD----TQISSRAV-----YQCNTSNEHGYLLANA 432
+G+ + S +G TI ++ QISS ++ Y C SN A A
Sbjct: 691 RKDGQVIISG--------SGVTIESKEFMSSLQISSVSLKHNGNYTCIASN------AAA 736
Query: 433 FVS-----VLDVPPR-MLSPRNQLIRVILYNRTR-LDCPFFGSPIPTLRWFKNGQGSNLD 485
VS ++ VPPR ++ P NQ +Y + L+C G P P + W K+ +GS
Sbjct: 737 TVSRERQLIVRVPPRFVVQPNNQ---DGIYGKAGVLNCSVDGYPPPKVMW-KHAKGSGNP 792
Query: 486 G--------GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK-AENQVRLEVKDPTRIY 536
G + N SL I+ + +ED G Y C A+N +G + L VK P I
Sbjct: 793 QQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT 852
Query: 537 RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-------KEDDSLT 589
P +A +G +L C + + + + W K D + M+ D+ ++
Sbjct: 853 SHPNTTIAIKGHAKELNCTARGERPI--IIRWEKGDTVIDPDRVMRYAIATKDNGDEVVS 910
Query: 590 IFGVAERDQGS---YTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIP 646
+ D+G ++C A +D LTV PD P +LE+ ++ RS+ L W
Sbjct: 911 TLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP-ELEIREVKARSMNLRWTQ 969
Query: 647 GDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSA-VLRLSPYVNYQFRVIAINEVG 705
NS IT + ++++ ++N A ++ L P Y R+ + N++G
Sbjct: 970 RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIG 1029
Query: 706 SSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRR 765
S PS T A P+ P DV + ++++TW G Y + +R
Sbjct: 1030 RSEPS-KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRE 1088
Query: 766 RETREAWN------NVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGED 819
T Y + + Y + VQA N G GP + + ED
Sbjct: 1089 NSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLED 1148
Query: 820 YPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQ 879
P P V+ + S + W+ T+ G L+ YR +W S + W +
Sbjct: 1149 VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFW--SLYVDGEWGEMQNIT 1206
Query: 880 ASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQP 939
+ LRG+ ++NY ++++ GDG RS T E VP P +
Sbjct: 1207 TTRERVELRGMEK----FTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPS 1262
Query: 940 NLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRY 999
+ ++ + W P PNG++ YT+ + + G+ SP Q + + + +Y
Sbjct: 1263 SASSVVVSWLPPTKPNGVIRKYTI-FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQY 1321
Query: 1000 RFTLSARTQVGSGEAVTEESPAPPNEA 1026
++A T G G + + + P +A
Sbjct: 1322 LLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
Score = 145 bits (365), Expect = 3e-34
Identities = 157/621 (25%), Positives = 257/621 (41%), Gaps = 58/621 (9%)
Query: 6 PPP---------WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIE 56
PPP W+ FLL L SL A P D+ S + +++
Sbjct: 50 PPPRRIGPLYGMWL-VTFLLLLDSLHKAR--PEDVGTSLYFVNDSLQQVTFSSSVGVVVP 106
Query: 57 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY--EGEYQCFA 114
C A G+P+ + W + +I P + +GTL + S + + +Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGD-DIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTA 165
Query: 115 RNKFGTALSNRIRLQ-VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS--PVIFWMS 171
N G S IR++ V + P + ++ G +C P + V+ W
Sbjct: 166 ENAAGKIRSPNIRVKAVFREPYTVR--VEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEK 223
Query: 172 SSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNH 231
++ I + R ++G LY S+V +D + Y C +T H
Sbjct: 224 DTVS-IIPEHRFFITYHGGLYISDVQKEDALSTYRC--------------------ITKH 262
Query: 232 PYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 291
Y+ + +++ S AE P+ + SQ V G + L C ASG P P I W
Sbjct: 263 KYSGETRQSNGARLSVTDPAESIPTIL---DGFHSQEVWAGHTVELPCTASGYPIPAIRW 319
Query: 292 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 351
K G LP+D +++ L I+++ EDSG Y C +N GS T + V +
Sbjct: 320 LKDGRPLPAD-SRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVT 378
Query: 352 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 411
PK L G L C G+P+ T++W N E + R ++ +T++ Q
Sbjct: 379 LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
Query: 412 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP 471
S YQC + + A +++ D PR++S ++ + V + L C G+P P
Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCAAKGAPPP 497
Query: 472 TLRWFKNGQGSNLDGG---NYHVYENGS----LEIKMIRKEDQGIYTCVATNILGKAENQ 524
T+ W + + DG N + +G+ + + + D G+Y C A N++G AE Q
Sbjct: 498 TVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557
Query: 525 VRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNR-MKK 583
R+ V+ P I R + A G + CRV P ++ W KD L +R +
Sbjct: 558 ARINVRGPPSI-RAMRNITAVAGRDTLINCRVIGYP--YYSIKWYKDALLLPDNHRQVVF 614
Query: 584 EDDSLTIFGVAE-RDQGSYTC 603
E+ +L + V + D+G Y C
Sbjct: 615 ENGTLKLTDVQKGMDEGEYLC 635
Score = 99.4 bits (246), Expect = 2e-20
Identities = 130/539 (24%), Positives = 209/539 (38%), Gaps = 69/539 (12%)
Query: 130 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH-N 188
V S + ++L V + + C P G PS + W ++ + I + H N
Sbjct: 81 VGTSLYFVNDSLQQVTFSSSVGVVVPC-PAAGSPSAALRWYLATGDDIYDVPHIRHVHAN 139
Query: 189 GDLY---FS----NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNH 241
G L FS N + D DY C A + I+ N +K + PY
Sbjct: 140 GTLQLYPFSPSAFNSFIHD--NDYFCTAE-NAAGKIRSPN-IRVKAVFREPYTVR----- 190
Query: 242 PDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC-IASGVP--TPDIAWYKKGGDL 298
Q +RG + +C I S V ++W K +
Sbjct: 191 ----------------------VEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSI 228
Query: 299 PSDKAKFENFNKALRITNVSEEDS-GEYFCLASNKM-GSIRHTISVRV------KAAPYW 350
+ F ++ L I++V +ED+ Y C+ +K G R + R+ ++ P
Sbjct: 229 IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTI 288
Query: 351 LDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ 410
LD + + G L C A+G P P ++W+ +G PL A + + G TI D +
Sbjct: 289 LDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLP-ADSRWTKRITGLTI--SDLR 345
Query: 411 ISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPI 470
Y C +N G A + V+D L+P+ ++ + + L C GSP
Sbjct: 346 TEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVILSCALTGSPE 403
Query: 471 PTLRWFKNGQGSNLDGG-NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV 529
T+RW++N + D + N +L I +K G Y C AT A++ + +
Sbjct: 404 FTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIAL 463
Query: 530 KDPT-RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL-----YIGNRMKK 583
+D T RI ++V G L C K P TV+W DDEP+ + N+
Sbjct: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP--TVTWALDDEPIVRDGSHRTNQYTM 521
Query: 584 EDDS----LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAER 638
D + + + G RD G Y C A + +A + V G P +T +A R
Sbjct: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGR 580
Score = 67.8 bits (164), Expect = 6e-11
Identities = 76/280 (27%), Positives = 116/280 (41%), Gaps = 17/280 (6%)
Query: 550 VQLECRVKHDPSLKLTVSWLKDDEPLYI-----GNRMKKEDDSLTIFGVAERDQGSYTCV 604
V+L C DP+ V W KD E I G+R+ + +L + V D G YTC
Sbjct: 1367 VRLPCNSVGDPAP--AVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 605 ASTELDQDLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEED 664
A+ D L V PD+PR L ++ + S+ LTWIPGD S I +V+Q+ D
Sbjct: 1425 ATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVD 1483
Query: 665 QFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPE 724
+ W D + + L Y+ ++ A N VGS S E +T G P
Sbjct: 1484 NSEE--WKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEA-KTHGREPS 1540
Query: 725 SNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV- 783
+ + T N+ + P ++++R + T AW + S V
Sbjct: 1541 FSKD--QHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGT-WAWQGLRANSSGEVF 1597
Query: 784 VGQTPVYVPYEIRVQAENDFGKGPEPE--SVIGYSGEDYP 821
+ + YE+R++A N G G E + + Y G P
Sbjct: 1598 LTELREATWYELRMRACNSAGCGNETAQFATLDYDGSTIP 1637
Score = 50.8 bits (120), Expect = 7e-06
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 460 RLDCPFFGSPIPTLRWFKNGQGSNLD---GGNYHVYENGSLEIKMIRKEDQGIYTCVATN 516
RL C G P P ++W K+ + S + G+ ++ NG+L ++ ++ ED G YTC ATN
Sbjct: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
Query: 517 ILGKAENQVRLEVKDP 532
G V L V+ P
Sbjct: 1428 TGGFDTIIVNLLVQVP 1443
Score = 40.0 bits (92), Expect = 0.013
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 15/108 (13%)
Query: 260 PQGTASSQMVLRG--------MDLLLECIASGVPTPDIAWYKKGGD----LPSDKAKFEN 307
P G A ++++ G D+ L C + G P P + W K D + D + +
Sbjct: 1344 PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIH 1403
Query: 308 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPK 355
N L + V EDSG Y C A+N G +++ V+ P D+P+
Sbjct: 1404 TNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPP---DQPR 1448
Score = 36.2 bits (82), Expect = 0.19
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 8/87 (9%)
Query: 363 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPP---NPNREV-AGDTIIFRDTQISSRAVYQ 418
+D RL C + G+P P V+W + E SA P + +R + T++ R + Y
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSE--DSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
Query: 419 CNTSNEHGY--LLANAFVSVLDVPPRM 443
C +N G+ ++ N V V PR+
Sbjct: 1423 CTATNTGGFDTIIVNLLVQVPPDQPRL 1449
Score = 31.2 bits (69), Expect = 6.1
Identities = 33/138 (23%), Positives = 55/138 (39%), Gaps = 11/138 (7%)
Query: 927 VPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQT 986
VP R V + + +I L W ++ + G+ L+Y N + + S ++
Sbjct: 1442 VPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFI---SSSER 1498
Query: 987 KFTVQRTDPVSRYRFTLSARTQVGSG------EAVTE-ESPAPPNEATPTAAYTNNQADI 1039
F + + Y+ L+A+ VGSG EA T P+ + + A +
Sbjct: 1499 SFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARL 1558
Query: 1040 ATQGWFIGLMCAIALLVL 1057
QGW G C I +VL
Sbjct: 1559 NLQGWNNG-GCPITAIVL 1575
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 199 bits (507), Expect = 1e-50
Identities = 213/804 (26%), Positives = 319/804 (39%), Gaps = 71/804 (8%)
Query: 265 SSQMVLRGMDLLLECIA-SGVPTPDIAWYKKGGDLP--SDKAKFENFNKALRITNV---- 317
S + +RG ++LL+C A S P I W K G L D+ K + N +L I N+
Sbjct: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
Query: 318 -SEEDSGEYFCLAS-NKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGN 374
+ D G Y C AS GS I T V V +L + +++ G+ L C G
Sbjct: 107 HHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGE 166
Query: 375 PKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN- 431
P PT+ W N + L P + V +G I R Q +Y+C+ N N
Sbjct: 167 PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR-LQPGDIGIYRCSARNPASSRTGNE 225
Query: 432 AFVSVLDVP----PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 487
A V +L P R + I L+C G P P+ W + + L
Sbjct: 226 AEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSK 285
Query: 488 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRG 547
Y + +L I + +D G+YTCV T L V P P + A
Sbjct: 286 KYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYES 345
Query: 548 TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDS-LTIFGVAERDQGSYTCVAS 606
++ EC V P TV+W+K+ + + + + S L I GV + D+G Y CVA
Sbjct: 346 MDIEFECTVSGKP--VPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAE 403
Query: 607 TELDQDLAKAYLTV--------LGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYV 658
E A L V P PRD+ ++ R VRL+W P I +
Sbjct: 404 NEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFT 463
Query: 659 VQF--EEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERY 716
V F E D + + ++ PGS+ V L P Y FRV+A NE G P S+
Sbjct: 464 VFFSREGDNRERAL---NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWG---PGESSQPI 517
Query: 717 RTSGAPPESNPGDV---KGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWN 773
+ + P PG V + T ++ ITW P A GP Y + T +
Sbjct: 518 KVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVSTGKE-Q 574
Query: 774 NVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM 833
N+ V G Y + + Y +R A N +G G + + + D P A P V + V+
Sbjct: 575 NIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV 634
Query: 834 NSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSR 893
NS +I + W S T G + Y+ +++ +++ + + + L + +
Sbjct: 635 NSRSIKVSWLPPPSGTQNGFITGYK---------IRHRKTTRRGEMETLEPNNLWYLFTG 685
Query: 894 LFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEG------VPSAPRRFRVRQPNLETINLE 947
L S Y ++ + G GP S TPE VP P VR P I +
Sbjct: 686 LEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR-PQTNCIIMS 744
Query: 948 WDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE--NFSPNQTKFTVQRTDPVSRYRFTLSA 1005
W P +PN ++ GY + Y VG E Q ++++R + S Y +L A
Sbjct: 745 WTPPLNPNIVVRGYIIGY------GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA 798
Query: 1006 RTQVGSG----EAVTEESPAPPNE 1025
G G E+ T S P +
Sbjct: 799 FNNAGEGVPLYESATTRSITDPTD 822
Score = 157 bits (398), Expect = 4e-38
Identities = 234/1039 (22%), Positives = 398/1039 (38%), Gaps = 141/1039 (13%)
Query: 52 NILIECEAKGNPA-PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
N+L++C A+ + P W ++ + D R L+ + + EG Y
Sbjct: 56 NVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLY 115
Query: 111 QCFAR-NKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 169
QC A G+ +S ++ V+ PL + V G + L+C G P P I W
Sbjct: 116 QCEASLGDSGSIISRTAKVAVA-GPLRFLSQTESVTAFMGDTVLLKCEVI-GEPMPTIHW 173
Query: 170 MSSSME--PITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
+ + PI D RV +G L S + D+ Y C+AR NP
Sbjct: 174 QKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGI-YRCSAR----------NP----- 217
Query: 228 LTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 287
++ N++ +R + S G+ + P S+ + + G D +LEC SG P P
Sbjct: 218 ASSRTGNEAEVR----ILSDPGLHRQLYFLQRP----SNVVAIEGKDAVLECCVSGYPPP 269
Query: 288 DIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
W + + K+ + L I+NV+++DSG Y C+ + K +I + + V
Sbjct: 270 SFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV 329
Query: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406
P++L+ P NL D C +G P PTV WM NG+ + P + + V G +
Sbjct: 330 PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV--IPSDYFQIVGGSNLRI 387
Query: 407 RDTQISSRAVYQCNTSNEHGYLLANAFV----------SVLDVPPRMLSPRNQLIRVILY 456
S YQC NE G +A + SVL PR + P R +
Sbjct: 388 LGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRL 447
Query: 457 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT--CVA 514
+ R G+ I T F + +G N + + + GSL++ + + + +YT VA
Sbjct: 448 S-WRPPAEAKGN-IQTFTVFFSREGDNRERA-LNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
Query: 515 TNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 574
N G E+ P ++ PE QV G L+ V P+ + ++W + P
Sbjct: 505 YNEWGPGES------SQPIKVATQPELQVP--GPVENLQA-VSTSPT-SILITW---EPP 551
Query: 575 LY----------------IGNRMKKEDDSLT--IFGVAERDQGSYTCVASTELDQDLAKA 616
Y G E D L+ + G+ + + S +A ++
Sbjct: 552 AYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
Query: 617 YLTVLGRPD----RPRDLELTDLAERSVRLTWI--PGDANNSPITDYVVQFEEDQFQPGV 670
+TV+ D P+++ L + RS++++W+ P N IT Y ++ + + +
Sbjct: 612 DITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM 671
Query: 671 WHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPS------LPSERYRTSGAPPE 724
+ P ++ L Y F+V A+ G+ PS P S P +
Sbjct: 672 ---ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQ 728
Query: 725 SNPGDVKGEGTRKNNMEITWTPMNATSAFGPNL---RYIVKWRRRETREAWNNVTVWGSR 781
+ V+ + N + ++WTP PN+ YI+ + V
Sbjct: 729 PSSLHVR---PQTNCIIMSWTP-----PLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
Query: 782 YVVGQTPVYVPYEIRVQAENDFGKG------------PEPESVIGYSG--EDYPRAA--- 824
Y + + Y I ++A N+ G+G +P + Y +D+P +
Sbjct: 781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL 840
Query: 825 ------PTEVKVRVMNSTAISLQW--NRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQK 876
P V+ + A+ + W N V + ++R Y WR S + S+
Sbjct: 841 STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLY-TVRWRTSFSASAKYKSED 899
Query: 877 RQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVP-SAPRRFR 935
S+ L+ P + Y+ ++V R S T TT E P SAP+
Sbjct: 900 TTSLSYTATGLK-------PNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLT 952
Query: 936 V--RQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRT 993
V R+ + + W P NG + Y L Y + I+E S ++ +
Sbjct: 953 VITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDL 1012
Query: 994 DPVSRYRFTLSARTQVGSG 1012
+ + Y F + AR G G
Sbjct: 1013 NLDTMYYFRIQARNSKGVG 1031
Score = 77.4 bits (189), Expect = 7e-14
Identities = 80/292 (27%), Positives = 112/292 (38%), Gaps = 45/292 (15%)
Query: 51 DNILIECEAKGNPAPSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 109
D +L++CE G P P+ HW +N + I D RV + SG L I G G
Sbjct: 155 DTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVV-LPSGALQISRLQPGD----IGI 209
Query: 110 YQCFARNKFGTALSNRIRLQVSKSP-----LWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
Y+C ARN + N +++ P L+ + VV EG L+C G P
Sbjct: 210 YRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEC-CVSGYPP 268
Query: 165 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
P W+ + K+ S +L SNV D Y+C + I T
Sbjct: 269 PSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV-TDDDSGMYTCVVTYK-NENISASAELT 326
Query: 225 LKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGV 284
+ V P+ NHP S+ MD+ EC SG
Sbjct: 327 VLV---PPW----FLNHP----------------------SNLYAYESMDIEFECTVSGK 357
Query: 285 PTPDIAWYKKGG-DLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGS 335
P P + W K G +PSD + LRI V + D G Y C+A N+ G+
Sbjct: 358 PVPTVNWMKNGDVVIPSDYFQIVG-GSNLRILGVVKSDEGFYQCVAENEAGN 408
Score = 33.9 bits (76), Expect = 0.94
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 9/81 (11%)
Query: 534 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE---DDSLTI 590
R P D V RG V L+C + D + + + W KD L +G +K+ + SL I
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPV-IKWKKDGIHLALGMDERKQQLSNGSLLI 99
Query: 591 FGVA-----ERDQGSYTCVAS 606
+ + D+G Y C AS
Sbjct: 100 QNILHSRHHKPDEGLYQCEAS 120
Score = 33.5 bits (75), Expect = 1.2
Identities = 45/198 (22%), Positives = 80/198 (40%), Gaps = 17/198 (8%)
Query: 627 PRDLELTDLAERSVRLTW----IPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 682
P ++ L +VR++W +P + S + Y V++ + S+ S++
Sbjct: 847 PVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYK--SEDTTSLS 904
Query: 683 SAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGD---VKGEGTRKNN 739
L P Y+F V+ SS S+ + T A P S P D + EG +
Sbjct: 905 YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKDLTVITREG-KPRA 962
Query: 740 MEITWTPMNATSAFGPNLRYIVKWR--RRETREAWNNVTVWGSR--YVVGQTPVYVPYEI 795
+ ++W P A G YI+ + + + W T+ G R + + + Y
Sbjct: 963 VIVSWQP--PLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
Query: 796 RVQAENDFGKGPEPESVI 813
R+QA N G GP + ++
Sbjct: 1021 RIQARNSKGVGPLSDPIL 1038
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 189 bits (479), Expect = 2e-47
Identities = 188/697 (26%), Positives = 288/697 (41%), Gaps = 55/697 (7%)
Query: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTII 405
P ++ P++ G VC+A G PKP + WM G+ + S + AG +
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 406 FRDTQIS-SRAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLS-PRNQLIRVILYNRTR 460
+ ++ A+Y+C +N G + +A +SVL+ +PP S ++V+ RT
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTA 152
Query: 461 -LDCPFFGSPIPTLRWFKNGQGSN--LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNI 517
+ C G+P P + WFK+ + G +G+L+I+ + DQG Y CVATN
Sbjct: 153 TMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNS 212
Query: 518 LGK-----AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 572
G A VR+ P R P Q G +V L C P V W+
Sbjct: 213 AGTRYSAPANLYVRVRRVAP-RFSIPPSSQEVMPGGSVNLTCVAVGAPMPY--VKWMMGA 269
Query: 573 EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLEL 632
E L + M + L + V +YTCVA + L A A +TV P P DL +
Sbjct: 270 EELTKEDEMPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKALPKPPIDLVV 327
Query: 633 TDLAERSVRLTWIPGDANNSPITDYVVQFE----EDQFQPGVWHDHSKYPGSVNSAVLRL 688
T+ SV LTW G N+ P+T Y +Q+ E FQ ++Y ++ L
Sbjct: 328 TETTATSVTLTWDSG--NSEPVTYYGIQYRAAGTEGPFQEVDGVATTRY------SIGGL 379
Query: 689 SPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMN 748
SP+ Y FRV+A+N +G PS + R RT P S P V+ + M + W P
Sbjct: 380 SPFSEYAFRVLAVNSIGRGPPS-EAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 749 ATSAFGPNLRYIVKWRRRETREAWN-NVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGP 807
+ R R AW+ + T G VG + Y +RV A G GP
Sbjct: 439 EPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGP 498
Query: 808 EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSL 867
P I + A P + + V + T I L W Q ++ Y YW
Sbjct: 499 -PSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLL----PPQERIIMYELVYWA---- 549
Query: 868 LKNLWVSQKRQQASFPGDRLRG-VVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEG 926
+ QQ D + L P + Y+ ++ + G G + T E T +
Sbjct: 550 -----AEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 927 VPSA-PRRFRVRQPNLETINLEWDHP--EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSP 983
PSA P++ T+ + W P + NG++ Y++ Y A +G G+ +V+ S
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 984 NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
+ + + + + YR + A T VG G E SP
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPG---PESSP 698
Score = 149 bits (377), Expect = 1e-35
Identities = 157/586 (26%), Positives = 246/586 (41%), Gaps = 49/586 (8%)
Query: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS---LEIKMIR-KEDQGIYTCVATNIL 518
C G P P + W K G+ + +++G+ L I+ +R + D+ IY C ATN L
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 519 GKAENQVRLEVKDPTR-------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
G+ +L V + + I P+ +V + T + C +P + +SW KD
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPE--ISWFKD 171
Query: 572 D---EPLYIGNRMKK-EDDSLTIFGVAERDQGSYTCVASTELDQDL-AKAYLTVLGRPDR 626
+P R+K+ +L I E DQG Y CVA+ A A L V R
Sbjct: 172 FLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVA 231
Query: 627 PRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVL 686
PR + S + +PG + N ++ G + V VL
Sbjct: 232 PR----FSIPPSSQEV--MPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVL 285
Query: 687 RLSPYV-NYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWT 745
LS V + + +AI+ +G + + T A P+ P D+ T ++ +TW
Sbjct: 286 ELSNVVRSANYTCVAISSLGM----IEATAQVTVKALPKP-PIDLVVTETTATSVTLTWD 340
Query: 746 PMNATSAFGPNLRYIVKWRRRETREAWNNVT-VWGSRYVVGQTPVYVPYEIRVQAENDFG 804
N+ P Y +++R T + V V +RY +G + Y RV A N G
Sbjct: 341 SGNSE----PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIG 396
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
+GP E+V +GE P + P V+ R+++++ + +QW + G +R YR YY +
Sbjct: 397 RGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTPD 454
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
S N W L V L P Y L ++ GDGP S T + T
Sbjct: 455 SRRPPNAWHKHNTDAG------LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ 508
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPN 984
+GVP+ P F+ + I L W P P +I Y L Y A +Q F P
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWA--AEDEDQQHKVTFDPT 564
Query: 985 QTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTA 1030
+ +T++ P + YRF L+AR+ +G G T A ++TP+A
Sbjct: 565 -SSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSA 608
Score = 148 bits (373), Expect = 3e-35
Identities = 179/791 (22%), Positives = 315/791 (39%), Gaps = 95/791 (12%)
Query: 279 CIASGVPTPDIAWYKKGGDLPSDKAKFENFN----KALRITNVS-EEDSGEYFCLASNKM 333
C A+G P P I W KKG + S + + F+ LRI + + D Y C A+N +
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 334 GSIRHTISVRV-------KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 386
G I + + V P P+ ++ ++C A GNP P + W +
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFL 173
Query: 387 PLQSAPPNPN-REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL---ANAFVSVLDVPPR 442
P+ A N +++ + ++ S + Y+C +N G AN +V V V PR
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPR 233
Query: 443 M-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 501
+ P +Q V+ L C G+P+P ++W + L + LE+
Sbjct: 234 FSIPPSSQ--EVMPGGSVNLTCVAVGAPMPYVKWMMGAE--ELTKEDEMPVGRNVLELSN 289
Query: 502 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPS 561
+ + YTCVA + LG E ++ VK + + P D V T +
Sbjct: 290 VVRSAN--YTCVAISSLGMIEATAQVTVK---ALPKPPIDLVVTETT------------A 332
Query: 562 LKLTVSW-LKDDEPL-YIGNRMK--------KEDDSL-----TIFGVAERDQGSYTCVAS 606
+T++W + EP+ Y G + + +E D + +I G++ + ++ +A
Sbjct: 333 TSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV 392
Query: 607 TELDQ----DLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFE 662
+ + + +A PR ++ L+ ++ + W P + N + Y V +
Sbjct: 393 NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYT 452
Query: 663 EDQFQ-PGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA 721
D + P WH H+ G + + V L P + Y RV+A VG PS P+ + +T
Sbjct: 453 PDSRRPPNAWHKHNTDAGLL-TTVGSLLPGITYSLRVLAFTAVGDGPPS-PTIQVKTQQG 510
Query: 722 PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYI----VKWRRRETREAWNNVTV 777
P + P D + E ++++W P R I V W + +
Sbjct: 511 VP-AQPADFQAEVESDTRIQLSW-------LLPPQERIIMYELVYWAAEDEDQQHKVTFD 562
Query: 778 WGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 837
S Y + Y ++ A +D G G ++ + + P A P +V M ST
Sbjct: 563 PTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTT 622
Query: 838 ISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQ--KRQQASFPGDRLRGVVSRLF 895
+ + W +D+ G + +Y Y + V R+ +S+ + L
Sbjct: 623 VRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWD-------LVGLE 675
Query: 896 PYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSA-PRRFRVRQPNLETINLEW--DHPE 952
++ Y++ + G GP S T E VPS PR+ V N +++ W P
Sbjct: 676 KWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS 735
Query: 953 HPNGIMIGYTLKYVAF-NGTKVGKQIVEN-------FSPNQT---KFTVQRTDPVSRYRF 1001
+G + GY + YV NG G I+++ + P ++ + T+ P + Y
Sbjct: 736 KQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSV 795
Query: 1002 TLSARTQVGSG 1012
T++A T G G
Sbjct: 796 TVAAYTTKGDG 806
Score = 118 bits (296), Expect = 3e-26
Identities = 105/416 (25%), Positives = 175/416 (42%), Gaps = 23/416 (5%)
Query: 619 TVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP 678
T G P +P D + ++ ++L+W+ + + V ED+ Q H
Sbjct: 507 TQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQ-----QHKVTF 561
Query: 679 GSVNSAVLR-LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRK 737
+S L L P Y+F++ A +++G P+ RT+ + P + P V
Sbjct: 562 DPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 738 NNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRY-----VVGQTPVYVP 792
+ ++W P A S G +Y V + + + +V SR +VG +
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEK-WTE 679
Query: 793 YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQG 852
Y + V+A D G GPE V+ + ED P P +V+V +NSTA+ + W G
Sbjct: 680 YRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHG 739
Query: 853 QLREYRAYYWR-ESSLLKNLWVSQ-----KRQQASFPGDRLRGVVSRLFPYSNYKLEMVV 906
Q+R Y+ Y R E+ + L + Q + Q + +S L P + Y + +
Sbjct: 740 QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAA 799
Query: 907 VNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYV 966
+GDG RS+ K TT VP P + + T L+W P+ G ++GY L+Y
Sbjct: 800 YTTKGDGARSKPKIVTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGELLGYRLQYC 858
Query: 967 AFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAP 1022
+ + +F + FTV + Y F L+A+ + G GE +E P
Sbjct: 859 RADEARPN---TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTP 911
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/309 (26%), Positives = 116/309 (37%), Gaps = 60/309 (19%)
Query: 57 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGG---------RPEEYE 107
C+A G P P W + K +VS +R VI+F G R + E
Sbjct: 54 CQATGEPKPRITWMK--------KGKKVSSQRFE---VIEFDDGAGSVLRIQPLRVQRDE 102
Query: 108 GEYQCFARNKFGTALSNRIRLQVSKS----PLWPKENLDPV--VVQEGAPLTLQCNPPPG 161
Y+C A N G ++ +L V + P +P ++ P VV++ T+ C G
Sbjct: 103 AIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLC-AAGG 160
Query: 162 LPSPVIFWMSSSM--EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219
P P I W + +P T + R+ Q +G L + D Q Y C A
Sbjct: 161 NPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESD-QGKYECVAT--------- 210
Query: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279
N + R V P F P SSQ V+ G + L C
Sbjct: 211 --------------NSAGTRYSAPANLYVRVRRVAPRFSIPP---SSQEVMPGGSVNLTC 253
Query: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 339
+A G P P + W +L + N L ++NV S Y C+A + +G I T
Sbjct: 254 VAVGAPMPYVKWMMGAEELTKEDEMPVGRN-VLELSNVVR--SANYTCVAISSLGMIEAT 310
Query: 340 ISVRVKAAP 348
V VKA P
Sbjct: 311 AQVTVKALP 319
Score = 54.7 bits (130), Expect = 5e-07
Identities = 50/170 (29%), Positives = 74/170 (43%), Gaps = 20/170 (11%)
Query: 46 IVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRR----RSGTLVIDFRSGG 101
+V+ + C A GNP P W ++ + DP S R RSG L I+
Sbjct: 145 VVEKARTATMLCAAGGNPDPEISWFKDF----LPVDPATSNGRIKQLRSGALQIE----S 196
Query: 102 RPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPP 159
E +G+Y+C A N GT S L V + P+ ++ P V G + L C
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTC-VA 255
Query: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
G P P + WM + E +T++ + G N L SNV+ +Y+C A
Sbjct: 256 VGAPMPYVKWMMGA-EELTKEDEMPVGRN-VLELSNVV---RSANYTCVA 300
Score = 44.7 bits (104), Expect = 5e-04
Identities = 86/396 (21%), Positives = 146/396 (36%), Gaps = 49/396 (12%)
Query: 647 GDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGS 706
G+ PI V+ E Q++P D+ + + L+P Y V A G
Sbjct: 754 GEPRGLPIIQDVM-LAEAQWRPEESEDYE-------TTISGLTPETTYSVTVAAYTTKGD 805
Query: 707 SHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRR 766
S P + T+GA P + T N + W P G L Y +++ R
Sbjct: 806 GARSKP-KIVTTTGAVPGRPTMMIST--TAMNTALLQWHPPKELP--GELLGYRLQYCRA 860
Query: 767 ETREAWNNVTVWGS---RYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRA 823
+ EA N +G + V Y R+ A+N G G E E I + ED P
Sbjct: 861 D--EARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR-TPEDLPSG 917
Query: 824 APTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFP 883
P + V + ++ L W+ G++ Y + +++ Q+ Q +
Sbjct: 918 FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF-------RDINSQQELQNITTD 970
Query: 884 GDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLET 943
R ++ L P + Y +++ +G GP S + + T + FRV +
Sbjct: 971 ---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTS 1027
Query: 944 INLEWDHPEHPNGIM---IGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYR 1000
+ L W+ P+ + I Y + V +G + K I + P + Y
Sbjct: 1028 VLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIAD-------------LQPNTEYS 1074
Query: 1001 FTLSAR-TQVGSGEAVTEESPAP---PNEATPTAAY 1032
F L R + G + + AP P++ P +AY
Sbjct: 1075 FVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAY 1110
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 189 bits (479), Expect = 2e-47
Identities = 188/697 (26%), Positives = 288/697 (41%), Gaps = 55/697 (7%)
Query: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTII 405
P ++ P++ G VC+A G PKP + WM G+ + S + AG +
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLR 92
Query: 406 FRDTQIS-SRAVYQCNTSNEHGYLLANAFVSVLD---VPPRMLS-PRNQLIRVILYNRTR 460
+ ++ A+Y+C +N G + +A +SVL+ +PP S ++V+ RT
Sbjct: 93 IQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTA 152
Query: 461 -LDCPFFGSPIPTLRWFKNGQGSN--LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNI 517
+ C G+P P + WFK+ + G +G+L+I+ + DQG Y CVATN
Sbjct: 153 TMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNS 212
Query: 518 LGK-----AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 572
G A VR+ P R P Q G +V L C P V W+
Sbjct: 213 AGTRYSAPANLYVRVRRVAP-RFSIPPSSQEVMPGGSVNLTCVAVGAPMPY--VKWMMGA 269
Query: 573 EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLEL 632
E L + M + L + V +YTCVA + L A A +TV P P DL +
Sbjct: 270 EELTKEDEMPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKALPKPPIDLVV 327
Query: 633 TDLAERSVRLTWIPGDANNSPITDYVVQFE----EDQFQPGVWHDHSKYPGSVNSAVLRL 688
T+ SV LTW G N+ P+T Y +Q+ E FQ ++Y ++ L
Sbjct: 328 TETTATSVTLTWDSG--NSEPVTYYGIQYRAAGTEGPFQEVDGVATTRY------SIGGL 379
Query: 689 SPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMN 748
SP+ Y FRV+A+N +G PS + R RT P S P V+ + M + W P
Sbjct: 380 SPFSEYAFRVLAVNSIGRGPPS-EAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 749 ATSAFGPNLRYIVKWRRRETREAWN-NVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGP 807
+ R R AW+ + T G VG + Y +RV A G GP
Sbjct: 439 EPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGP 498
Query: 808 EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSL 867
P I + A P + + V + T I L W Q ++ Y YW
Sbjct: 499 -PSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLL----PPQERIIMYELVYWA---- 549
Query: 868 LKNLWVSQKRQQASFPGDRLRG-VVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEG 926
+ QQ D + L P + Y+ ++ + G G + T E T +
Sbjct: 550 -----AEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 927 VPSA-PRRFRVRQPNLETINLEWDHP--EHPNGIMIGYTLKYVAFNGTKVGKQIVENFSP 983
PSA P++ T+ + W P + NG++ Y++ Y A +G G+ +V+ S
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 984 NQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESP 1020
+ + + + + YR + A T VG G E SP
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPG---PESSP 698
Score = 150 bits (378), Expect = 9e-36
Identities = 178/782 (22%), Positives = 311/782 (39%), Gaps = 86/782 (10%)
Query: 279 CIASGVPTPDIAWYKKGGDLPSDKAKFENFN----KALRITNVS-EEDSGEYFCLASNKM 333
C A+G P P I W KKG + S + + F+ LRI + + D Y C A+N +
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 334 GSIRHTISVRV-------KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 386
G I + + V P P+ ++ ++C A GNP P + W +
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFL 173
Query: 387 PLQSAPPNPN-REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLL---ANAFVSVLDVPPR 442
P+ A N +++ + ++ S + Y+C +N G AN +V V V PR
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPR 233
Query: 443 M-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 501
+ P +Q V+ L C G+P+P ++W + L + LE+
Sbjct: 234 FSIPPSSQ--EVMPGGSVNLTCVAVGAPMPYVKWMMGAE--ELTKEDEMPVGRNVLELSN 289
Query: 502 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPS 561
+ + YTCVA + LG E ++ VK + + P D V T +
Sbjct: 290 VVRSAN--YTCVAISSLGMIEATAQVTVK---ALPKPPIDLVVTETT------------A 332
Query: 562 LKLTVSW-LKDDEPL-YIGNRMK--------KEDDSL-----TIFGVAERDQGSYTCVAS 606
+T++W + EP+ Y G + + +E D + +I G++ + ++ +A
Sbjct: 333 TSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV 392
Query: 607 TELDQ----DLAKAYLTVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFE 662
+ + + +A PR ++ L+ ++ + W P + N + Y V +
Sbjct: 393 NSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYT 452
Query: 663 EDQFQ-PGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGA 721
D + P WH H+ G + + V L P + Y RV+A VG PS P+ + +T
Sbjct: 453 PDSRRPPNAWHKHNTDAGLL-TTVGSLLPGITYSLRVLAFTAVGDGPPS-PTIQVKTQQG 510
Query: 722 PPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYI----VKWRRRETREAWNNVTV 777
P + P D + E ++++W P R I V W + +
Sbjct: 511 VP-AQPADFQAEVESDTRIQLSW-------LLPPQERIIMYELVYWAAEDEDQQHKVTFD 562
Query: 778 WGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 837
S Y + Y ++ A +D G G ++ + + P A P +V M ST
Sbjct: 563 PTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTT 622
Query: 838 ISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQ--KRQQASFPGDRLRGVVSRLF 895
+ + W +D+ G + +Y Y + V R+ +S+ + L
Sbjct: 623 VRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWD-------LVGLE 675
Query: 896 PYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSA-PRRFRVRQPNLETINLEW--DHPE 952
++ Y++ + G GP S T E VPS PR+ V N +++ W P
Sbjct: 676 KWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS 735
Query: 953 HPNGIMIGYTLKYVAF-NGTKVGKQIVEN-FSPNQTKFTVQRTDPVSRYRFTLSARTQVG 1010
+G + GY + YV NG G I+++ + T+ P + Y T++A T G
Sbjct: 736 KQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKG 795
Query: 1011 SG 1012
G
Sbjct: 796 DG 797
Score = 149 bits (377), Expect = 1e-35
Identities = 157/586 (26%), Positives = 246/586 (41%), Gaps = 49/586 (8%)
Query: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS---LEIKMIR-KEDQGIYTCVATNIL 518
C G P P + W K G+ + +++G+ L I+ +R + D+ IY C ATN L
Sbjct: 54 CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL 113
Query: 519 GKAENQVRLEVKDPTR-------IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 571
G+ +L V + + I P+ +V + T + C +P + +SW KD
Sbjct: 114 GEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPE--ISWFKD 171
Query: 572 D---EPLYIGNRMKK-EDDSLTIFGVAERDQGSYTCVASTELDQDL-AKAYLTVLGRPDR 626
+P R+K+ +L I E DQG Y CVA+ A A L V R
Sbjct: 172 FLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVA 231
Query: 627 PRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVL 686
PR + S + +PG + N ++ G + V VL
Sbjct: 232 PR----FSIPPSSQEV--MPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVL 285
Query: 687 RLSPYV-NYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWT 745
LS V + + +AI+ +G + + T A P+ P D+ T ++ +TW
Sbjct: 286 ELSNVVRSANYTCVAISSLGM----IEATAQVTVKALPKP-PIDLVVTETTATSVTLTWD 340
Query: 746 PMNATSAFGPNLRYIVKWRRRETREAWNNVT-VWGSRYVVGQTPVYVPYEIRVQAENDFG 804
N+ P Y +++R T + V V +RY +G + Y RV A N G
Sbjct: 341 SGNSE----PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIG 396
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
+GP E+V +GE P + P V+ R+++++ + +QW + G +R YR YY +
Sbjct: 397 RGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTPD 454
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
S N W L V L P Y L ++ GDGP S T + T
Sbjct: 455 SRRPPNAWHKHNTDAG------LLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQ 508
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPN 984
+GVP+ P F+ + I L W P P +I Y L Y A +Q F P
Sbjct: 509 QGVPAQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWA--AEDEDQQHKVTFDPT 564
Query: 985 QTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTA 1030
+ +T++ P + YRF L+AR+ +G G T A ++TP+A
Sbjct: 565 -SSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSA 608
Score = 119 bits (298), Expect = 2e-26
Identities = 105/411 (25%), Positives = 174/411 (42%), Gaps = 22/411 (5%)
Query: 619 TVLGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYP 678
T G P +P D + ++ ++L+W+ + + V ED+ Q H
Sbjct: 507 TQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQ-----QHKVTF 561
Query: 679 GSVNSAVLR-LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRK 737
+S L L P Y+F++ A +++G P+ RT+ + P + P V
Sbjct: 562 DPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVMCVSMGS 620
Query: 738 NNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRY-----VVGQTPVYVP 792
+ ++W P A S G +Y V + + + +V SR +VG +
Sbjct: 621 TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEK-WTE 679
Query: 793 YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQG 852
Y + V+A D G GPE V+ + ED P P +V+V +NSTA+ + W G
Sbjct: 680 YRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHG 739
Query: 853 QLREYRAYYWR-ESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRG 911
Q+R Y+ Y R E+ + L + Q A + +S L P + Y + + +G
Sbjct: 740 QIRGYQVTYVRLENGEPRGLPIIQDVMLA----EAQETTISGLTPETTYSVTVAAYTTKG 795
Query: 912 DGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGT 971
DG RS+ K TT VP P + + T L+W P+ G ++GY L+Y +
Sbjct: 796 DGARSKPKIVTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEA 854
Query: 972 KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAP 1022
+ +F + FTV + Y F L+A+ + G GE +E P
Sbjct: 855 RPN---TIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTP 902
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/309 (26%), Positives = 116/309 (37%), Gaps = 60/309 (19%)
Query: 57 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGG---------RPEEYE 107
C+A G P P W + K +VS +R VI+F G R + E
Sbjct: 54 CQATGEPKPRITWMK--------KGKKVSSQRFE---VIEFDDGAGSVLRIQPLRVQRDE 102
Query: 108 GEYQCFARNKFGTALSNRIRLQVSKS----PLWPKENLDPV--VVQEGAPLTLQCNPPPG 161
Y+C A N G ++ +L V + P +P ++ P VV++ T+ C G
Sbjct: 103 AIYECTATNSLGE-INTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLC-AAGG 160
Query: 162 LPSPVIFWMSSSM--EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219
P P I W + +P T + R+ Q +G L + D Q Y C A
Sbjct: 161 NPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESD-QGKYECVAT--------- 210
Query: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279
N + R V P F P SSQ V+ G + L C
Sbjct: 211 --------------NSAGTRYSAPANLYVRVRRVAPRFSIPP---SSQEVMPGGSVNLTC 253
Query: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 339
+A G P P + W +L + N L ++NV S Y C+A + +G I T
Sbjct: 254 VAVGAPMPYVKWMMGAEELTKEDEMPVGRN-VLELSNVVR--SANYTCVAISSLGMIEAT 310
Query: 340 ISVRVKAAP 348
V VKA P
Sbjct: 311 AQVTVKALP 319
Score = 54.7 bits (130), Expect = 5e-07
Identities = 50/170 (29%), Positives = 74/170 (43%), Gaps = 20/170 (11%)
Query: 46 IVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRR----RSGTLVIDFRSGG 101
+V+ + C A GNP P W ++ + DP S R RSG L I+
Sbjct: 145 VVEKARTATMLCAAGGNPDPEISWFKDF----LPVDPATSNGRIKQLRSGALQIE----S 196
Query: 102 RPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPP 159
E +G+Y+C A N GT S L V + P+ ++ P V G + L C
Sbjct: 197 SEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTC-VA 255
Query: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
G P P + WM + E +T++ + G N L SNV+ +Y+C A
Sbjct: 256 VGAPMPYVKWMMGA-EELTKEDEMPVGRN-VLELSNVV---RSANYTCVA 300
Score = 43.1 bits (100), Expect = 0.002
Identities = 78/355 (21%), Positives = 131/355 (36%), Gaps = 41/355 (11%)
Query: 688 LSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPM 747
L+P Y V A G S P + T+GA P + T N + W P
Sbjct: 778 LTPETTYSVTVAAYTTKGDGARSKP-KIVTTTGAVPGRPTMMIST--TAMNTALLQWHPP 834
Query: 748 NATSAFGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPVYVPYEIRVQAENDFG 804
G L Y +++ R + EA N +G + V Y R+ A+N G
Sbjct: 835 KELP--GELLGYRLQYCRAD--EARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAG 890
Query: 805 KGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRE 864
G E E I + ED P P + V + ++ L W+ G++ Y +
Sbjct: 891 LGEEFEKEIR-TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF--- 946
Query: 865 SSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTP 924
+++ Q+ Q + R ++ L P + Y +++ +G GP S + + T
Sbjct: 947 ----RDINSQQELQNITTD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 999
Query: 925 EGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIM---IGYTLKYVAFNGTKVGKQIVENF 981
+ FRV ++ L W+ P+ + I Y + V +G + K I +
Sbjct: 1000 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIAD-- 1057
Query: 982 SPNQTKFTVQRTDPVSRYRFTLSAR-TQVGSGEAVTEESPAP---PNEATPTAAY 1032
P + Y F L R + G + + AP P++ P +AY
Sbjct: 1058 -----------LQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAY 1101
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 186 bits (471), Expect = 1e-46
Identities = 211/860 (24%), Positives = 328/860 (38%), Gaps = 123/860 (14%)
Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
RL+ P E+ ++V +G P TL C G P+P I W E + DK +
Sbjct: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78
Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSS 237
H +G L+F ++ + + Y C AR + + + +L +
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD------D 132
Query: 238 LRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGG 296
R +P S MV G ++EC G P P I+W K G
Sbjct: 133 FRQNP----------------------SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170
Query: 297 DLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPK 355
L + L IT + D+G+Y C+ +N +G ++ + V P ++ P
Sbjct: 171 PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPS 230
Query: 356 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSR 414
NL + + C A G+P PTV+W + L P E+ D T+ R
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDM 286
Query: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
Y C N G A+A ++V + P ++ PR+Q+ V L C G+P P +
Sbjct: 287 GSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIF 344
Query: 475 WFKNGQGSNL-------DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 527
W + G + L + V + G L I +++ D G Y C N+ G + L
Sbjct: 345 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 404
Query: 528 EVKD------PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNR 580
EV D P I + P +Q T L C P T+ W KD + +R
Sbjct: 405 EVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSR 462
Query: 581 MKK-EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG-----RPDRPRDL---- 630
+K+ E+ L I D G YTC+AST + AY+ V +P RP D
Sbjct: 463 IKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP 522
Query: 631 ------ELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSA 684
E+TD++ +V L+W P + + T Y+++ W ++ + SA
Sbjct: 523 SAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSA 581
Query: 685 VLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNN----- 739
+ L P Y F V A N G S PS S+ +T P S D K N
Sbjct: 582 IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHL 641
Query: 740 ----------MEITWTPMNATSAFGPNLRYIVK----------WRRRETREAWNNVTVWG 779
+E+ WT ++ S + + + + W E R N
Sbjct: 642 HNPTVLSSSSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKN----- 695
Query: 780 SRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVM--NSTA 837
V+ V YEI+ + + +G + E + E+ P A P V V N TA
Sbjct: 696 -SVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTA 754
Query: 838 ISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPY 897
I + W DT G ++EY+ + L N ++ + G V+ L P
Sbjct: 755 ILVSWQPPPEDTQNGMVQEYKVW------CLGN--ETRYHINKTVDGSTFSVVIPFLVPG 806
Query: 898 SNYKLEMVVVNGRGDGPRSE 917
Y +E+ G G G +SE
Sbjct: 807 IRYSVEVAASTGAGSGVKSE 826
Score = 169 bits (429), Expect = 1e-41
Identities = 141/514 (27%), Positives = 222/514 (43%), Gaps = 52/514 (10%)
Query: 34 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
PP I + + D IV + + C+A+G P P+ W + KD S R SG
Sbjct: 28 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 92 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
+L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
P ++C PP G P P I W +D+R++ G L + D Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203
Query: 211 FHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVL 270
T+ + ++ ++ V ER PSF+ S+ V
Sbjct: 204 ---TNMVGERESEVAELT---------------------VLER-PSFV---KRPSNLAVT 235
Query: 271 RGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLAS 330
+C A G P P + W K G+LP + + + + L+I V+ D G Y C+A
Sbjct: 236 VDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAE 294
Query: 331 NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP--- 387
N +G + ++ V+ P+++ +P++ ++A G C A GNP+P + W G
Sbjct: 295 NMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 354
Query: 388 LQSAPPNPNREVA----GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV---- 439
PP + + GD I + Q S Y C T N G ++ A++ V DV
Sbjct: 355 FSYQPPQSSSRFSVSQTGDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 413
Query: 440 PPRML--SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSL 497
PP ++ P NQ + V L C GSP+PT+ W K+G + ENG L
Sbjct: 414 PPPVIRQGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 471
Query: 498 EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 531
+I+ + D G YTC+A+ G+A +EV++
Sbjct: 472 QIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
Score = 76.3 bits (186), Expect = 2e-13
Identities = 90/370 (24%), Positives = 141/370 (38%), Gaps = 60/370 (16%)
Query: 31 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN-----SRFFNIAKDPRVS 85
L +P + + S VD D+ +CEA+G+P P+ W ++ + I D +
Sbjct: 220 LERPSFVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLK 277
Query: 86 MRR-RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV 144
+R+ +G + G Y C A N G A ++ L V + P + + D V
Sbjct: 278 IRKVTAGDM--------------GSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRDQV 322
Query: 145 VVQEGAPLTLQCNPPPGLPSPVIFW-------MSSSMEPITQDKRVSQGHNGDLYFSNVM 197
V G +T QC G P P IFW + S +P R S GDL +NV
Sbjct: 323 VAL-GRTVTFQCE-ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
Query: 198 LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSF 257
D+ Y C TL V S+ + +A+R P
Sbjct: 381 RSDVGY-YICQ---------------TLNVA-------GSIITKAYLEVTDVIADRPPP- 416
Query: 258 MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITN 316
+ QG + + + G +L C+A+G P P I W K G + + ++ + N L+I
Sbjct: 417 VIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475
Query: 317 VSEEDSGEYFCLASNKMGSIRHTISVRVK--AAPYWLDEPKNLILAPGEDGRLVCRANGN 374
D+G Y C+AS G + + V+ P P + L P +
Sbjct: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 535
Query: 375 PKPTVQWMVN 384
T+ W N
Sbjct: 536 NTVTLSWQPN 545
Score = 31.2 bits (69), Expect = 6.1
Identities = 21/109 (19%), Positives = 39/109 (35%), Gaps = 2/109 (1%)
Query: 922 TTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENF 981
T P +PSAP + V + T+ L W + Y ++ + + + EN
Sbjct: 516 TDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 575
Query: 982 SPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTA 1030
+ ++ P + Y F + A G + P + PT+
Sbjct: 576 KTETS--AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTS 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,157,579
Number of Sequences: 37866
Number of extensions: 2588120
Number of successful extensions: 17092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 301
Number of HSP's successfully gapped in prelim test: 238
Number of HSP's that attempted gapping in prelim test: 6908
Number of HSP's gapped (non-prelim): 4988
length of query: 1174
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1061
effective length of database: 13,968,660
effective search space: 14820748260
effective search space used: 14820748260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.