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Search of human proteins with 237858582
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237858582 cyclin-dependent kinase 10 isoform d [Homo
sapiens]
(289 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 593 e-170
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 593 e-170
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens] 573 e-164
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 523 e-149
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 303 1e-82
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 302 2e-82
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 302 2e-82
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 214 7e-56
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 211 6e-55
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 206 1e-53
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 206 1e-53
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 204 7e-53
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 204 7e-53
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 204 7e-53
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 203 1e-52
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 198 5e-51
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 197 1e-50
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 197 1e-50
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 197 1e-50
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 196 2e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 193 1e-49
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 192 2e-49
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 192 4e-49
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 192 4e-49
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 183 2e-46
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 593 bits (1529), Expect = e-170
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
Query: 241 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 289
ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Sbjct: 241 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 289
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 593 bits (1529), Expect = e-170
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 72 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 131
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 132 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 191
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 192 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 251
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 252 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 311
Query: 241 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 289
ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Sbjct: 312 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 360
>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
Length = 283
Score = 573 bits (1477), Expect = e-164
Identities = 283/289 (97%), Positives = 283/289 (97%), Gaps = 6/289 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ 234
Query: 241 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 289
ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Sbjct: 235 ATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP 283
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 523 bits (1346), Expect = e-149
Identities = 257/257 (100%), Positives = 257/257 (100%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
Query: 241 ATAGDCLESSYFKEKPL 257
ATAGDCLESSYFKEKPL
Sbjct: 241 ATAGDCLESSYFKEKPL 257
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 447 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 506
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 507 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 566
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 567 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 626
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 627 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 686
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 687 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 734
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 456 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 515
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 516 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 575
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 576 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 635
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 636 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 695
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 696 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 743
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 424 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 483
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 484 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 543
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 544 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 603
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 604 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 663
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 664 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 711
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 653 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 700
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 202 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 261
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 262 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 321
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 322 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 381
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 382 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 441
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 442 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 489
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 303 bits (776), Expect = 1e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 517
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 518 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 577
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 578 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 637
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 638 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 697
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 698 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 745
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 302 bits (774), Expect = 2e-82
Identities = 147/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 505
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 506 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 565
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVT WYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 566 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 625
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP+V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 626 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 685
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 686 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 733
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 302 bits (774), Expect = 2e-82
Identities = 147/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 456 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 515
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 516 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 575
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
+K TP VVT WYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 576 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 635
Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
+ LGTPSE IWPG+S+LP+V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 636 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 695
Query: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 696 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 743
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 214 bits (545), Expect = 7e-56
Identities = 116/262 (44%), Positives = 168/262 (64%), Gaps = 9/262 (3%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
+D E +G+P +++REI+LL L+HPNIV L +VV ++ ++LV + QDL +++
Sbjct: 37 LDLEMEGVPSTAIREISLLKELKHPNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDS- 93
Query: 61 PTPFSEAQ---VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAY 117
TP SE +K + Q+L+G+ + H + +IHRDLK NLL+ + G +K ADFGLARA+
Sbjct: 94 -TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF 152
Query: 118 GVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQI 177
GVP++ T +VVTLWYRAPE+LLG+ TT++D+W++GCI AE++ + L PG SEI Q+
Sbjct: 153 GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQL 212
Query: 178 DLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDP 237
I ++LGTPSE+ WPG ++LP + S K L+ P L G LL L YDP
Sbjct: 213 FRIFRMLGTPSEDTWPGVTQLPDY-KGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDP 271
Query: 238 KKRATAGDCLESSYFKE-KPLP 258
+R TA L YF +P P
Sbjct: 272 SQRITAKTALAHPYFSSPEPSP 293
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 211 bits (537), Expect = 6e-55
Identities = 116/266 (43%), Positives = 167/266 (62%), Gaps = 16/266 (6%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLES-IFLVMGYCEQDL-----A 54
+D E +G+P +++REI+LL L HPNIV+L +V+ H E+ ++LV + QDL A
Sbjct: 37 LDTETEGVPSTAIREISLLKELNHPNIVKLLDVI---HTENKLYLVFEFLHQDLKKFMDA 93
Query: 55 SLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLA 114
S L +P P +K + Q+L+GL + H + ++HRDLK NLL+ +G +K ADFGLA
Sbjct: 94 SALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA 149
Query: 115 RAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEI 174
RA+GVPV+ T +VVTLWYRAPE+LLG +T++D+W++GCI AE++ R L PG SEI
Sbjct: 150 RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209
Query: 175 HQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM 234
Q+ I + LGTP E +WPG + +P + S K + P L E G LL +
Sbjct: 210 DQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLH 268
Query: 235 YDPKKRATAGDCLESSYFKE--KPLP 258
YDP KR +A L +F++ KP+P
Sbjct: 269 YDPNKRISAKAALAHPFFQDVTKPVP 294
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 206 bits (525), Expect = 1e-53
Identities = 109/278 (39%), Positives = 158/278 (56%), Gaps = 11/278 (3%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
+D EK+G PI+++REI +L +L H ++V +KE+V + +LV Y + D
Sbjct: 760 LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD 819
Query: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
L LLE+ FSE +K + Q++ GL+Y H+ +HRD+K SN+L+ + G +K ADFG
Sbjct: 820 LMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFG 879
Query: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 880 LARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 939
Query: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
E+ Q++LI +L G+P +WP KLP +KQ L+ +F ++ A L LL
Sbjct: 940 LELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDH 999
Query: 232 LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPH 269
+ DP KR TA L+S + K+ L P PH
Sbjct: 1000 MLTLDPSKRCTAEQTLQSDFLKDVEL--SKMAPPDLPH 1035
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 206 bits (525), Expect = 1e-53
Identities = 109/278 (39%), Positives = 158/278 (56%), Gaps = 11/278 (3%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
+D EK+G PI+++REI +L +L H ++V +KE+V + +LV Y + D
Sbjct: 760 LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD 819
Query: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
L LLE+ FSE +K + Q++ GL+Y H+ +HRD+K SN+L+ + G +K ADFG
Sbjct: 820 LMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFG 879
Query: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 880 LARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 939
Query: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
E+ Q++LI +L G+P +WP KLP +KQ L+ +F ++ A L LL
Sbjct: 940 LELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDH 999
Query: 232 LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPH 269
+ DP KR TA L+S + K+ L P PH
Sbjct: 1000 MLTLDPSKRCTAEQTLQSDFLKDVEL--SKMAPPDLPH 1035
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 204 bits (519), Expect = 7e-53
Identities = 109/254 (42%), Positives = 153/254 (60%), Gaps = 4/254 (1%)
Query: 5 KDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPF 64
KDGI ++LREI LL L HPNI+ L + H +I LV + E DL ++++
Sbjct: 52 KDGINRTALREIKLLQELSHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVL 109
Query: 65 SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM 124
+ + +K +L L+GL+YLH+++I+HRDLK +NLL+ + G +K ADFGLA+++G P +
Sbjct: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY 169
Query: 125 TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLL 184
T +VVT WYRAPELL G +DMWAVGCILAELL P LPG S++ Q+ I + L
Sbjct: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229
Query: 185 GTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAG 244
GTP+E WP LP + + P L H F + L L+ LF+++P R TA
Sbjct: 230 GTPTEEQWPDMCSLP--DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287
Query: 245 DCLESSYFKEKPLP 258
L+ YF +P P
Sbjct: 288 QALKMKYFSNRPGP 301
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 204 bits (519), Expect = 7e-53
Identities = 104/274 (37%), Positives = 157/274 (57%), Gaps = 13/274 (4%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
+D EK+G PI+++REI +L +L H +I+ +KE+V + +LV Y + D
Sbjct: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
Query: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
L LLE+ F+E +K + Q++ GL Y H+ +HRD+K SN+L+ ++G +K ADFG
Sbjct: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
Query: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
Query: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
E+ Q++LI ++ G+P +WP KLP +KQ L+ +F ++ A L L +
Sbjct: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
Query: 232 LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMP 265
+ DP KR TA L+ + ++ EP MP
Sbjct: 978 MLALDPSKRCTAEQALQCEFLRD----VEPSKMP 1007
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 204 bits (519), Expect = 7e-53
Identities = 104/274 (37%), Positives = 157/274 (57%), Gaps = 13/274 (4%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
+D EK+G PI+++REI +L +L H +I+ +KE+V + +LV Y + D
Sbjct: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
Query: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
L LLE+ F+E +K + Q++ GL Y H+ +HRD+K SN+L+ ++G +K ADFG
Sbjct: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
Query: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
Query: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
E+ Q++LI ++ G+P +WP KLP +KQ L+ +F ++ A L L +
Sbjct: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
Query: 232 LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMP 265
+ DP KR TA L+ + ++ EP MP
Sbjct: 978 MLALDPSKRCTAEQALQCEFLRD----VEPSKMP 1007
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 203 bits (517), Expect = 1e-52
Identities = 114/296 (38%), Positives = 171/296 (57%), Gaps = 15/296 (5%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
+ ++G P +++RE++LL L+H NIV L ++V + +S+ LV Y ++DL +++
Sbjct: 226 EHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTD--KSLTLVFEYLDKDLKQYMDDCGN 283
Query: 63 PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
S VK + Q+LRGL Y HR ++HRDLK NLL+ +KG +K ADFGLARA VP K
Sbjct: 284 IMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTK 343
Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
+ +VVTLWYR P++LLG++ +T IDMW VGCI E+ + RPL PG++ ++ LI +
Sbjct: 344 TYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFR 403
Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
LLGTPS+ WPG S Y+ K L + P L G+ L+ Y+ KKR +
Sbjct: 404 LLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVS 463
Query: 243 AGDCLESSYFKE--KPLPCEPELMPTF----------PHHRNKRAAPATSEGQSKR 286
A + ++ YF+ + PE + F P RN + P T G+++R
Sbjct: 464 AEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNS-SYPETGHGKNRR 518
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 198 bits (503), Expect = 5e-51
Identities = 102/256 (39%), Positives = 158/256 (61%), Gaps = 5/256 (1%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
++ E++G+P +++REI+LL LRHPNIV L++V++ + ++L+ + DL L+++
Sbjct: 37 LESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSI 94
Query: 61 PTP--FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYG 118
P + VK + Q+L+G+ + H ++HRDLK NLL+ DKG +K ADFGLARA+G
Sbjct: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154
Query: 119 VPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQID 178
+P++ T +VVTLWYR+PE+LLG+ +T +D+W++G I AEL +PL G SEI Q+
Sbjct: 155 IPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214
Query: 179 LIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPK 238
I + LGTP+ +WP L + +P +L L E GL LL + +YDP
Sbjct: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPA 273
Query: 239 KRATAGDCLESSYFKE 254
KR + L YF +
Sbjct: 274 KRISGKMALNHPYFND 289
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 197 bits (500), Expect = 1e-50
Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
+ ++G P +++RE++LL L+H NIV L +++ + S+ LV Y + DL L++
Sbjct: 208 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 265
Query: 63 PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
S VK + Q+LRGL Y H I+HRDLK NLL+ ++G +K ADFGLARA VP K
Sbjct: 266 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 325
Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
+ +VVTLWYR P++LLG+T +T IDMW VGCI E+ RPL PG++ ++ LI +
Sbjct: 326 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 385
Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
LLGTP+E WPG + YS L + P L G+ LL L +Y+ K R +
Sbjct: 386 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 445
Query: 243 AGDCLESSYFK 253
A L SYF+
Sbjct: 446 AEAALSHSYFR 456
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 197 bits (500), Expect = 1e-50
Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
+ ++G P +++RE++LL L+H NIV L +++ + S+ LV Y + DL L++
Sbjct: 178 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 235
Query: 63 PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
S VK + Q+LRGL Y H I+HRDLK NLL+ ++G +K ADFGLARA VP K
Sbjct: 236 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 295
Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
+ +VVTLWYR P++LLG+T +T IDMW VGCI E+ RPL PG++ ++ LI +
Sbjct: 296 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 355
Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
LLGTP+E WPG + YS L + P L G+ LL L +Y+ K R +
Sbjct: 356 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 415
Query: 243 AGDCLESSYFK 253
A L SYF+
Sbjct: 416 AEAALSHSYFR 426
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 197 bits (500), Expect = 1e-50
Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
+ ++G P +++RE++LL L+H NIV L +++ + S+ LV Y + DL L++
Sbjct: 178 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 235
Query: 63 PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
S VK + Q+LRGL Y H I+HRDLK NLL+ ++G +K ADFGLARA VP K
Sbjct: 236 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 295
Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
+ +VVTLWYR P++LLG+T +T IDMW VGCI E+ RPL PG++ ++ LI +
Sbjct: 296 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 355
Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
LLGTP+E WPG + YS L + P L G+ LL L +Y+ K R +
Sbjct: 356 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 415
Query: 243 AGDCLESSYFK 253
A L SYF+
Sbjct: 416 AEAALSHSYFR 426
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 196 bits (498), Expect = 2e-50
Identities = 100/256 (39%), Positives = 157/256 (61%), Gaps = 5/256 (1%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
++ E++G+P +++REI+LL LRHPNIV L++V++ + ++L+ + DL L+++
Sbjct: 37 LESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSI 94
Query: 61 PTP--FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYG 118
P + VK + Q+L+G+ + H ++HRDLK NLL+ DKG +K ADFGLARA+G
Sbjct: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154
Query: 119 VPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQID 178
+P++ T + +TLWYR+PE+LLG+ +T +D+W++G I AEL +PL G SEI Q+
Sbjct: 155 IPIRVYTHEAITLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214
Query: 179 LIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPK 238
I + LGTP+ +WP L + +P +L L E GL LL + +YDP
Sbjct: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPA 273
Query: 239 KRATAGDCLESSYFKE 254
KR + L YF +
Sbjct: 274 KRISGKMALNHPYFND 289
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 193 bits (491), Expect = 1e-49
Identities = 106/255 (41%), Positives = 152/255 (59%), Gaps = 4/255 (1%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
+D + +G+P S+LREI LL L+H NIV L +V+ + + + LV +C+QDL ++
Sbjct: 37 LDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSC 94
Query: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
VK + Q+L+GL + H ++HRDLK NLL+ G +K ADFGLARA+G+P
Sbjct: 95 NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154
Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELL-AHRPLLPGTSEIHQIDL 179
V+ + +VVTLWYR P++L G +TSIDMW+ GCI AEL A RPL PG Q+
Sbjct: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214
Query: 180 IVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKK 239
I +LLGTP+E WP +KLP Y + +L + P L+ G LL L +P +
Sbjct: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-TSLVNVVPKLNATGRDLLQNLLKCNPVQ 273
Query: 240 RATAGDCLESSYFKE 254
R +A + L+ YF +
Sbjct: 274 RISAEEALQHPYFSD 288
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 192 bits (489), Expect = 2e-49
Identities = 105/272 (38%), Positives = 153/272 (56%), Gaps = 12/272 (4%)
Query: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVV------VGNHLESIFLVMGYCEQDLA 54
M+ EK+G PI++LREI +L L+H N+V L E+ SI+LV +CE DLA
Sbjct: 52 MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA 111
Query: 55 SLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLA 114
LL N+ F+ +++K ++ +L GL Y+HRN I+HRD+K +N+L+T G +K ADFGLA
Sbjct: 112 GLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171
Query: 115 RAYGVPVKPM----TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPG 170
RA+ + T +VVTLWYR PELLLG ID+W GCI+AE+ P++ G
Sbjct: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231
Query: 171 TSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWL--SEAGLRL 228
+E HQ+ LI QL G+ + +WP L + L K +K + L L
Sbjct: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291
Query: 229 LHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 260
+ L + DP +R + D L +F P+P +
Sbjct: 292 IDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 192 bits (487), Expect = 4e-49
Identities = 101/251 (40%), Positives = 149/251 (59%), Gaps = 4/251 (1%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMP 61
+ ++G P +++RE++LL L+H NIV L +++ H E S+ LV Y ++DL L++
Sbjct: 205 EHEEGAPCTAIREVSLLKDLKHANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCG 261
Query: 62 TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV 121
+ VK + Q+LRGL Y HR ++HRDLK NLL+ ++G +K ADFGLARA +P
Sbjct: 262 NIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT 321
Query: 122 KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIV 181
K + +VVTLWYR P++LLG+T +T IDMW VGCI E+ RPL PG++ Q+ I
Sbjct: 322 KTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF 381
Query: 182 QLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRA 241
++LGTP+E WPG Y+ K L P L G LL L ++ + R
Sbjct: 382 RILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI 441
Query: 242 TAGDCLESSYF 252
+A D ++ +F
Sbjct: 442 SAEDAMKHPFF 452
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 192 bits (487), Expect = 4e-49
Identities = 101/251 (40%), Positives = 149/251 (59%), Gaps = 4/251 (1%)
Query: 3 KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMP 61
+ ++G P +++RE++LL L+H NIV L +++ H E S+ LV Y ++DL L++
Sbjct: 199 EHEEGAPCTAIREVSLLKDLKHANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCG 255
Query: 62 TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV 121
+ VK + Q+LRGL Y HR ++HRDLK NLL+ ++G +K ADFGLARA +P
Sbjct: 256 NIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT 315
Query: 122 KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIV 181
K + +VVTLWYR P++LLG+T +T IDMW VGCI E+ RPL PG++ Q+ I
Sbjct: 316 KTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF 375
Query: 182 QLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRA 241
++LGTP+E WPG Y+ K L P L G LL L ++ + R
Sbjct: 376 RILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI 435
Query: 242 TAGDCLESSYF 252
+A D ++ +F
Sbjct: 436 SAEDAMKHPFF 446
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 183 bits (464), Expect = 2e-46
Identities = 107/252 (42%), Positives = 150/252 (59%), Gaps = 12/252 (4%)
Query: 7 GIPISSLREITLLLRLR---HPNIVELKEVVVGNHLE---SIFLVMGYCEQDLASLLENM 60
G+PIS++RE+ LL RL HPN+V L +V + + + LV + +QDL + L+
Sbjct: 48 GLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA 107
Query: 61 PTPFSEAQ-VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGV 119
P P A+ +K ++ Q LRGL +LH N I+HRDLK N+L+T G VK ADFGLAR Y
Sbjct: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY 167
Query: 120 PVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDL 179
+ +TP VVTLWYRAPE+LL +T T +DMW+VGCI AE+ +PL G SE Q+
Sbjct: 168 QM-ALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 225
Query: 180 IVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKK 239
I L+G P E+ WP LP +P ++ P + E+G +LL + ++P K
Sbjct: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSV---VPEMEESGAQLLLEMLTFNPHK 282
Query: 240 RATAGDCLESSY 251
R +A L+ SY
Sbjct: 283 RISAFRALQHSY 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,627,455
Number of Sequences: 37866
Number of extensions: 525429
Number of successful extensions: 2632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 733
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 1093
Number of HSP's gapped (non-prelim): 892
length of query: 289
length of database: 18,247,518
effective HSP length: 101
effective length of query: 188
effective length of database: 14,423,052
effective search space: 2711533776
effective search space used: 2711533776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.