Search of human proteins with 237858575

Search of human proteins with 237858575

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|237858575 cyclin-dependent kinase 10 isoform b [Homo
sapiens]
         (272 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      556   e-159
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      523   e-149
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      523   e-149
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      503   e-143
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   288   3e-78
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    288   5e-78
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    288   5e-78
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   214   8e-56
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        209   3e-54
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   206   2e-53
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   206   2e-53
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   205   4e-53
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    204   9e-53
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    204   9e-53
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   202   3e-52
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             198   5e-51
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         197   1e-50
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         197   1e-50
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         197   1e-50
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           196   2e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   193   1e-49
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        192   3e-49
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          192   3e-49
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]                   191   6e-49
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    183   1e-46

>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  556 bits (1432), Expect = e-159
 Identities = 272/272 (100%), Positives = 272/272 (100%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
           PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
           VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240

Query: 241 ATAGDCLESSYFKEKPLRLPISGVCEGCREPG 272
           ATAGDCLESSYFKEKPLRLPISGVCEGCREPG
Sbjct: 241 ATAGDCLESSYFKEKPLRLPISGVCEGCREPG 272


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  523 bits (1346), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
           PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
           VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240

Query: 241 ATAGDCLESSYFKEKPL 257
           ATAGDCLESSYFKEKPL
Sbjct: 241 ATAGDCLESSYFKEKPL 257


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  523 bits (1346), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 72  MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 131

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
           PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 132 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 191

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 192 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 251

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
           VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR
Sbjct: 252 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 311

Query: 241 ATAGDCLESSYFKEKPL 257
           ATAGDCLESSYFKEKPL
Sbjct: 312 ATAGDCLESSYFKEKPL 328


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  503 bits (1294), Expect = e-143
 Identities = 251/257 (97%), Positives = 251/257 (97%), Gaps = 6/257 (2%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
           PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKR 240
           VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM      
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM------ 234

Query: 241 ATAGDCLESSYFKEKPL 257
           ATAGDCLESSYFKEKPL
Sbjct: 235 ATAGDCLESSYFKEKPL 251


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 447 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 506

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 507 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 566

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 567 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 626

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 627 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 686

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 687 RISAEDGLKHEYFRETPL 704


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 456 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 515

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 516 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 575

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 576 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 635

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 636 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 695

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 696 RISAEDGLKHEYFRETPL 713


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 424 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 483

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 484 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 543

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 544 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 603

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 604 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 663

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 664 RISAEDGLKHEYFRETPL 681


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 653 RISAEDGLKHEYFRETPL 670


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 202 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 261

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 262 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 321

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 322 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 381

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 382 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 441

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 442 RISAEDGLKHEYFRETPL 459


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  288 bits (738), Expect = 3e-78
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 517

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 518 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 577

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 578 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 637

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 638 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 697

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 698 RISAEDGLKHEYFRETPL 715


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  288 bits (736), Expect = 5e-78
 Identities = 136/258 (52%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 505

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 506 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 565

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVT WYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 566 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 625

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP+V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 626 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 685

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 686 RISAEDGLKHEYFRETPL 703


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  288 bits (736), Expect = 5e-78
 Identities = 136/258 (52%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 456 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 515

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 516 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 575

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
           +K  TP VVT WYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 576 LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKV 635

Query: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
            + LGTPSE IWPG+S+LP+V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 636 FKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 695

Query: 240 RATAGDCLESSYFKEKPL 257
           R +A D L+  YF+E PL
Sbjct: 696 RISAEDGLKHEYFRETPL 713


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  214 bits (544), Expect = 8e-56
 Identities = 114/255 (44%), Positives = 165/255 (64%), Gaps = 8/255 (3%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           +D E +G+P +++REI+LL  L+HPNIV L +VV  ++   ++LV  +  QDL   +++ 
Sbjct: 37  LDLEMEGVPSTAIREISLLKELKHPNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDS- 93

Query: 61  PTPFSEAQ---VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAY 117
            TP SE     +K  + Q+L+G+ + H + +IHRDLK  NLL+ + G +K ADFGLARA+
Sbjct: 94  -TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAF 152

Query: 118 GVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQI 177
           GVP++  T +VVTLWYRAPE+LLG+   TT++D+W++GCI AE++  + L PG SEI Q+
Sbjct: 153 GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQL 212

Query: 178 DLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDP 237
             I ++LGTPSE+ WPG ++LP   + S  K     L+   P L   G  LL  L  YDP
Sbjct: 213 FRIFRMLGTPSEDTWPGVTQLPDY-KGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDP 271

Query: 238 KKRATAGDCLESSYF 252
            +R TA   L   YF
Sbjct: 272 SQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  209 bits (531), Expect = 3e-54
 Identities = 114/266 (42%), Positives = 165/266 (62%), Gaps = 14/266 (5%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLES-IFLVMGYCEQDL-----A 54
           +D E +G+P +++REI+LL  L HPNIV+L +V+   H E+ ++LV  +  QDL     A
Sbjct: 37  LDTETEGVPSTAIREISLLKELNHPNIVKLLDVI---HTENKLYLVFEFLHQDLKKFMDA 93

Query: 55  SLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLA 114
           S L  +P P     +K  + Q+L+GL + H + ++HRDLK  NLL+  +G +K ADFGLA
Sbjct: 94  SALTGIPLPL----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA 149

Query: 115 RAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEI 174
           RA+GVPV+  T +VVTLWYRAPE+LLG    +T++D+W++GCI AE++  R L PG SEI
Sbjct: 150 RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209

Query: 175 HQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFM 234
            Q+  I + LGTP E +WPG + +P   + S  K    +     P L E G  LL  +  
Sbjct: 210 DQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLH 268

Query: 235 YDPKKRATAGDCLESSYFKEKPLRLP 260
           YDP KR +A   L   +F++    +P
Sbjct: 269 YDPNKRISAKAALAHPFFQDVTKPVP 294


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  206 bits (523), Expect = 2e-53
 Identities = 106/266 (39%), Positives = 155/266 (58%), Gaps = 9/266 (3%)

Query: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
            +D EK+G PI+++REI +L +L H ++V +KE+V              + +LV  Y + D
Sbjct: 760  LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD 819

Query: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
            L  LLE+    FSE  +K  + Q++ GL+Y H+   +HRD+K SN+L+ + G +K ADFG
Sbjct: 820  LMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFG 879

Query: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 880  LARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 939

Query: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
             E+ Q++LI +L G+P   +WP   KLP       +KQ    L+ +F ++  A L LL  
Sbjct: 940  LELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDH 999

Query: 232  LFMYDPKKRATAGDCLESSYFKEKPL 257
            +   DP KR TA   L+S + K+  L
Sbjct: 1000 MLTLDPSKRCTAEQTLQSDFLKDVEL 1025


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  206 bits (523), Expect = 2e-53
 Identities = 106/266 (39%), Positives = 155/266 (58%), Gaps = 9/266 (3%)

Query: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
            +D EK+G PI+++REI +L +L H ++V +KE+V              + +LV  Y + D
Sbjct: 760  LDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD 819

Query: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
            L  LLE+    FSE  +K  + Q++ GL+Y H+   +HRD+K SN+L+ + G +K ADFG
Sbjct: 820  LMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFG 879

Query: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 880  LARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 939

Query: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
             E+ Q++LI +L G+P   +WP   KLP       +KQ    L+ +F ++  A L LL  
Sbjct: 940  LELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDH 999

Query: 232  LFMYDPKKRATAGDCLESSYFKEKPL 257
            +   DP KR TA   L+S + K+  L
Sbjct: 1000 MLTLDPSKRCTAEQTLQSDFLKDVEL 1025


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  205 bits (521), Expect = 4e-53
 Identities = 112/267 (41%), Positives = 157/267 (58%), Gaps = 10/267 (3%)

Query: 5   KDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPF 64
           KDGI  ++LREI LL  L HPNI+ L +     H  +I LV  + E DL  ++++     
Sbjct: 52  KDGINRTALREIKLLQELSHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVL 109

Query: 65  SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM 124
           + + +K  +L  L+GL+YLH+++I+HRDLK +NLL+ + G +K ADFGLA+++G P +  
Sbjct: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY 169

Query: 125 TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLL 184
           T +VVT WYRAPELL G       +DMWAVGCILAELL   P LPG S++ Q+  I + L
Sbjct: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229

Query: 185 GTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAG 244
           GTP+E  WP    LP     + +  P   L H F    +  L L+  LF+++P  R TA 
Sbjct: 230 GTPTEEQWPDMCSLP--DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287

Query: 245 DCLESSYFKEKPLRLPISGVCEGCREP 271
             L+  YF  +P      G   GC+ P
Sbjct: 288 QALKMKYFSNRP------GPTPGCQLP 308


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  204 bits (518), Expect = 9e-53
 Identities = 102/270 (37%), Positives = 158/270 (58%), Gaps = 10/270 (3%)

Query: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
            +D EK+G PI+++REI +L +L H +I+ +KE+V              + +LV  Y + D
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
            L  LLE+    F+E  +K  + Q++ GL Y H+   +HRD+K SN+L+ ++G +K ADFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
             E+ Q++LI ++ G+P   +WP   KLP       +KQ    L+ +F ++  A L L  +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977

Query: 232  LFMYDPKKRATAGDCLESSYFKE-KPLRLP 260
            +   DP KR TA   L+  + ++ +P ++P
Sbjct: 978  MLALDPSKRCTAEQALQCEFLRDVEPSKMP 1007


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  204 bits (518), Expect = 9e-53
 Identities = 102/270 (37%), Positives = 158/270 (58%), Gaps = 10/270 (3%)

Query: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
            +D EK+G PI+++REI +L +L H +I+ +KE+V              + +LV  Y + D
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
            L  LLE+    F+E  +K  + Q++ GL Y H+   +HRD+K SN+L+ ++G +K ADFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
             E+ Q++LI ++ G+P   +WP   KLP       +KQ    L+ +F ++  A L L  +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977

Query: 232  LFMYDPKKRATAGDCLESSYFKE-KPLRLP 260
            +   DP KR TA   L+  + ++ +P ++P
Sbjct: 978  MLALDPSKRCTAEQALQCEFLRDVEPSKMP 1007


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  202 bits (514), Expect = 3e-52
 Identities = 104/251 (41%), Positives = 155/251 (61%), Gaps = 2/251 (0%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
           + ++G P +++RE++LL  L+H NIV L ++V  +  +S+ LV  Y ++DL   +++   
Sbjct: 226 EHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTD--KSLTLVFEYLDKDLKQYMDDCGN 283

Query: 63  PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
             S   VK  + Q+LRGL Y HR  ++HRDLK  NLL+ +KG +K ADFGLARA  VP K
Sbjct: 284 IMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTK 343

Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
             + +VVTLWYR P++LLG++  +T IDMW VGCI  E+ + RPL PG++   ++ LI +
Sbjct: 344 TYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFR 403

Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
           LLGTPS+  WPG S       Y+  K     L +  P L   G+ L+     Y+ KKR +
Sbjct: 404 LLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVS 463

Query: 243 AGDCLESSYFK 253
           A + ++  YF+
Sbjct: 464 AEEAMKHVYFR 474


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  198 bits (503), Expect = 5e-51
 Identities = 102/256 (39%), Positives = 158/256 (61%), Gaps = 5/256 (1%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           ++ E++G+P +++REI+LL  LRHPNIV L++V++ +    ++L+  +   DL   L+++
Sbjct: 37  LESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSI 94

Query: 61  PTP--FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYG 118
           P       + VK  + Q+L+G+ + H   ++HRDLK  NLL+ DKG +K ADFGLARA+G
Sbjct: 95  PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154

Query: 119 VPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQID 178
           +P++  T +VVTLWYR+PE+LLG+   +T +D+W++G I AEL   +PL  G SEI Q+ 
Sbjct: 155 IPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214

Query: 179 LIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPK 238
            I + LGTP+  +WP    L        + +P  +L      L E GL LL  + +YDP 
Sbjct: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPA 273

Query: 239 KRATAGDCLESSYFKE 254
           KR +    L   YF +
Sbjct: 274 KRISGKMALNHPYFND 289


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  197 bits (500), Expect = 1e-50
 Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
           + ++G P +++RE++LL  L+H NIV L +++  +   S+ LV  Y + DL   L++   
Sbjct: 208 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 265

Query: 63  PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
             S   VK  + Q+LRGL Y H   I+HRDLK  NLL+ ++G +K ADFGLARA  VP K
Sbjct: 266 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 325

Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
             + +VVTLWYR P++LLG+T  +T IDMW VGCI  E+   RPL PG++   ++ LI +
Sbjct: 326 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 385

Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
           LLGTP+E  WPG +       YS        L +  P L   G+ LL  L +Y+ K R +
Sbjct: 386 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 445

Query: 243 AGDCLESSYFK 253
           A   L  SYF+
Sbjct: 446 AEAALSHSYFR 456


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  197 bits (500), Expect = 1e-50
 Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
           + ++G P +++RE++LL  L+H NIV L +++  +   S+ LV  Y + DL   L++   
Sbjct: 178 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 235

Query: 63  PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
             S   VK  + Q+LRGL Y H   I+HRDLK  NLL+ ++G +K ADFGLARA  VP K
Sbjct: 236 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 295

Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
             + +VVTLWYR P++LLG+T  +T IDMW VGCI  E+   RPL PG++   ++ LI +
Sbjct: 296 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 355

Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
           LLGTP+E  WPG +       YS        L +  P L   G+ LL  L +Y+ K R +
Sbjct: 356 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 415

Query: 243 AGDCLESSYFK 253
           A   L  SYF+
Sbjct: 416 AEAALSHSYFR 426


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  197 bits (500), Expect = 1e-50
 Identities = 106/251 (42%), Positives = 150/251 (59%), Gaps = 2/251 (0%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
           + ++G P +++RE++LL  L+H NIV L +++  +   S+ LV  Y + DL   L++   
Sbjct: 178 EHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGN 235

Query: 63  PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
             S   VK  + Q+LRGL Y H   I+HRDLK  NLL+ ++G +K ADFGLARA  VP K
Sbjct: 236 LMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTK 295

Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 182
             + +VVTLWYR P++LLG+T  +T IDMW VGCI  E+   RPL PG++   ++ LI +
Sbjct: 296 TYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFR 355

Query: 183 LLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRAT 242
           LLGTP+E  WPG +       YS        L +  P L   G+ LL  L +Y+ K R +
Sbjct: 356 LLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMS 415

Query: 243 AGDCLESSYFK 253
           A   L  SYF+
Sbjct: 416 AEAALSHSYFR 426


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  196 bits (498), Expect = 2e-50
 Identities = 100/256 (39%), Positives = 157/256 (61%), Gaps = 5/256 (1%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           ++ E++G+P +++REI+LL  LRHPNIV L++V++ +    ++L+  +   DL   L+++
Sbjct: 37  LESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSI 94

Query: 61  PTP--FSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYG 118
           P       + VK  + Q+L+G+ + H   ++HRDLK  NLL+ DKG +K ADFGLARA+G
Sbjct: 95  PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154

Query: 119 VPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQID 178
           +P++  T + +TLWYR+PE+LLG+   +T +D+W++G I AEL   +PL  G SEI Q+ 
Sbjct: 155 IPIRVYTHEAITLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214

Query: 179 LIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPK 238
            I + LGTP+  +WP    L        + +P  +L      L E GL LL  + +YDP 
Sbjct: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPA 273

Query: 239 KRATAGDCLESSYFKE 254
           KR +    L   YF +
Sbjct: 274 KRISGKMALNHPYFND 289


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  193 bits (491), Expect = 1e-49
 Identities = 106/255 (41%), Positives = 152/255 (59%), Gaps = 4/255 (1%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
           +D + +G+P S+LREI LL  L+H NIV L +V+  +  + + LV  +C+QDL    ++ 
Sbjct: 37  LDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSC 94

Query: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
                   VK  + Q+L+GL + H   ++HRDLK  NLL+   G +K ADFGLARA+G+P
Sbjct: 95  NGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP 154

Query: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELL-AHRPLLPGTSEIHQIDL 179
           V+  + +VVTLWYR P++L G    +TSIDMW+ GCI AEL  A RPL PG     Q+  
Sbjct: 155 VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKR 214

Query: 180 IVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKK 239
           I +LLGTP+E  WP  +KLP    Y +      +L +  P L+  G  LL  L   +P +
Sbjct: 215 IFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-TSLVNVVPKLNATGRDLLQNLLKCNPVQ 273

Query: 240 RATAGDCLESSYFKE 254
           R +A + L+  YF +
Sbjct: 274 RISAEEALQHPYFSD 288


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  192 bits (487), Expect = 3e-49
 Identities = 101/251 (40%), Positives = 149/251 (59%), Gaps = 4/251 (1%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMP 61
           + ++G P +++RE++LL  L+H NIV L +++   H E S+ LV  Y ++DL   L++  
Sbjct: 205 EHEEGAPCTAIREVSLLKDLKHANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCG 261

Query: 62  TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV 121
              +   VK  + Q+LRGL Y HR  ++HRDLK  NLL+ ++G +K ADFGLARA  +P 
Sbjct: 262 NIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT 321

Query: 122 KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIV 181
           K  + +VVTLWYR P++LLG+T  +T IDMW VGCI  E+   RPL PG++   Q+  I 
Sbjct: 322 KTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF 381

Query: 182 QLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRA 241
           ++LGTP+E  WPG         Y+  K     L    P L   G  LL  L  ++ + R 
Sbjct: 382 RILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI 441

Query: 242 TAGDCLESSYF 252
           +A D ++  +F
Sbjct: 442 SAEDAMKHPFF 452


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  192 bits (487), Expect = 3e-49
 Identities = 101/251 (40%), Positives = 149/251 (59%), Gaps = 4/251 (1%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMP 61
           + ++G P +++RE++LL  L+H NIV L +++   H E S+ LV  Y ++DL   L++  
Sbjct: 199 EHEEGAPCTAIREVSLLKDLKHANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCG 255

Query: 62  TPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV 121
              +   VK  + Q+LRGL Y HR  ++HRDLK  NLL+ ++G +K ADFGLARA  +P 
Sbjct: 256 NIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT 315

Query: 122 KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIV 181
           K  + +VVTLWYR P++LLG+T  +T IDMW VGCI  E+   RPL PG++   Q+  I 
Sbjct: 316 KTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIF 375

Query: 182 QLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRA 241
           ++LGTP+E  WPG         Y+  K     L    P L   G  LL  L  ++ + R 
Sbjct: 376 RILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI 435

Query: 242 TAGDCLESSYF 252
           +A D ++  +F
Sbjct: 436 SAEDAMKHPFF 446


>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
          Length = 372

 Score =  191 bits (485), Expect = 6e-49
 Identities = 105/276 (38%), Positives = 154/276 (55%), Gaps = 12/276 (4%)

Query: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVV------VGNHLESIFLVMGYCEQDLA 54
           M+ EK+G PI++LREI +L  L+H N+V L E+             SI+LV  +CE DLA
Sbjct: 52  MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA 111

Query: 55  SLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLA 114
            LL N+   F+ +++K ++  +L GL Y+HRN I+HRD+K +N+L+T  G +K ADFGLA
Sbjct: 112 GLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171

Query: 115 RAYGVPVKPM----TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPG 170
           RA+ +         T +VVTLWYR PELLLG       ID+W  GCI+AE+    P++ G
Sbjct: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231

Query: 171 TSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWL--SEAGLRL 228
            +E HQ+ LI QL G+ +  +WP      L  +  L K     +K +          L L
Sbjct: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291

Query: 229 LHFLFMYDPKKRATAGDCLESSYFKEKPLRLPISGV 264
           +  L + DP +R  + D L   +F   P+   + G+
Sbjct: 292 IDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGM 327


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  183 bits (465), Expect = 1e-46
 Identities = 103/260 (39%), Positives = 147/260 (56%), Gaps = 5/260 (1%)

Query: 3   KEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPT 62
           +E++G P +++RE +LL  L+H NIV L +++  +  E++ LV  Y   DL   ++  P 
Sbjct: 151 QEEEGTPFTAIREASLLKGLKHANIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPG 208

Query: 63  PFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVK 122
                 VK  + Q+LRGL Y+H+ +I+HRDLK  NLL++D G +K ADFGLARA  VP  
Sbjct: 209 GLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSH 268

Query: 123 PMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIH-QIDLIV 181
             + +VVTLWYR P++LLG+T  +T +DMW VGCI  E++      PG  +I  Q++ I 
Sbjct: 269 TYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIF 328

Query: 182 QLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLR--LLHFLFMYDPKK 239
            +LGTP+E+ WPG   LP             NL+  +  LS       L   L    PK 
Sbjct: 329 LVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKN 388

Query: 240 RATAGDCLESSYFKEKPLRL 259
           R +A   L   YF + P RL
Sbjct: 389 RLSAQAALSHEYFSDLPPRL 408


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,742,458
Number of Sequences: 37866
Number of extensions: 468151
Number of successful extensions: 2350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 850
Number of HSP's gapped (non-prelim): 865
length of query: 272
length of database: 18,247,518
effective HSP length: 101
effective length of query: 171
effective length of database: 14,423,052
effective search space: 2466341892
effective search space used: 2466341892
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.