Search of human proteins with 23503325

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23503325 mirror-image polydactyly 1 [Homo sapiens]
         (442 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23503325 mirror-image polydactyly 1 [Homo sapiens]                 862   0.0  
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     66   7e-11
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]                    64   2e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    64   2e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    64   2e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    64   2e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    64   2e-10
gi|55770834 centromere protein F [Homo sapiens]                        64   2e-10
gi|122937396 coiled-coil domain containing 150 [Homo sapiens]          64   2e-10
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       64   3e-10
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       64   3e-10
gi|118498368 kinectin 1 isoform c [Homo sapiens]                       64   3e-10
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        64   3e-10
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]         64   3e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    64   3e-10
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]                    64   4e-10
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]                      63   6e-10
gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]                    63   6e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    63   6e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    63   6e-10
gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]              62   1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    62   1e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        62   1e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        62   1e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         62   1e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         62   1e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         62   1e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         62   1e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         62   1e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         62   1e-09

>gi|23503325 mirror-image polydactyly 1 [Homo sapiens]
          Length = 442

 Score =  862 bits (2227), Expect = 0.0
 Identities = 442/442 (100%), Positives = 442/442 (100%)

Query: 1   MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR 60
           MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR
Sbjct: 1   MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR 60

Query: 61  STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL 120
           STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL
Sbjct: 61  STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL 120

Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA 180
           DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA
Sbjct: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA 180

Query: 181 VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
           VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN
Sbjct: 181 VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240

Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
           GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH
Sbjct: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300

Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
           LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN
Sbjct: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360

Query: 361 YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420
           YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ
Sbjct: 361 YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420

Query: 421 KLERLVDVLRKKVGTGTMRTVI 442
           KLERLVDVLRKKVGTGTMRTVI
Sbjct: 421 KLERLVDVLRKKVGTGTMRTVI 442


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 72/369 (19%), Positives = 169/369 (45%), Gaps = 41/369 (11%)

Query: 103  VTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKL---KFKLELQEKETEAKI 159
            +T + +K K++A L  + + + T    L+++L +E+K++++L   + KLE    +   +I
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITD---LEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064

Query: 160  AEKTAALVE-EVYFAQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN------ 211
            AE  A + E ++  A+KE + +A ++R++    +++ A+ + + +E  +  L+       
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124

Query: 212  -----INPEENDM--TLQELLNRINNADTGIAIQKNGAI-----------IVDRIYKTKE 253
                    ++ D+   L+ L   + +     A Q+                ++   KT E
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184

Query: 254  CKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTS----ANNMRHLTA----EN 305
             +++   ++ S  +EE    L + KR++  L   K+  +      AN ++ L        
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY-SLHKSLSQEENLKDQFNYTLS 364
            ++ + ++A+L  +Q       +   +L +++  L+V   ++   LSQ ++   +     S
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLER 424
              E  L++ + ++    +Q   L+T+L+Q   E+ +   QL+   EA     +++  L  
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 425  LVDVLRKKV 433
             V  ++KK+
Sbjct: 1365 QVADMKKKM 1373



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 80/319 (25%), Positives = 150/319 (47%), Gaps = 44/319 (13%)

Query: 123  LRTSNKKLQQ---KLAKEDKEQRKLKFKLELQEKETEAKI--AEKTAALVEEVYFAQKER 177
            L+   KK+QQ   +L ++ +E+   + KL+L++  TEAK+   E+   ++E+      + 
Sbjct: 934  LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993

Query: 178  DEAVMSRLQ------LAIEERDEAIARA--KHMEMSLKVLENINPEEND-MTLQELLNRI 228
             + +  R+          EE+ +++A+   KH  M   + E +  EE     L++   ++
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

Query: 229  NNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVK 288
                T ++ Q     I +   +  E KM++  +E     EE  AAL+   R+E+E     
Sbjct: 1054 EGDSTDLSDQ-----IAELQAQIAELKMQLAKKE-----EELQAALA---RVEEE----A 1096

Query: 289  EQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY--SLH 346
             Q   +   +R L ++ ++   L+  L S + +R  A +Q + L EE++ L+     +L 
Sbjct: 1097 AQKNMALKKIRELESQISE---LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153

Query: 347  KSLSQEE---NLKDQFNYTLSTYEEALKNRENIVSITQQQN----EELATQLQQALTERA 399
             + +Q+E     + + N    T EE  K  E  +   +Q++    EELA QL+Q    +A
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213

Query: 400  NMELQLQH-AREASQVANE 417
            N+E   Q    E  ++ANE
Sbjct: 1214 NLEKAKQTLENERGELANE 1232



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 84/361 (23%), Positives = 152/361 (42%), Gaps = 67/361 (18%)

Query: 119  ELDILRTSNKKLQQKLAKEDKEQRKLK-----FKLELQEKETEAKIAEKTAALVE---EV 170
            E++ L +S   + + + + +K +R L+      K +L+E E E +  E     +E   + 
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564

Query: 171  YFAQKERD-------------------EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE- 210
              AQ ERD                     + + L+   ++R  A+A  K +EM LK LE 
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624

Query: 211  -----NINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSA 265
                 N N +E    L++L  ++ +    +   +     +    K  E K++    EM  
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684

Query: 266  LIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETA 325
            L EE  AA    ++ +QE   + ++    AN+         ++R L+A++          
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADE---IANSSGKGALALEEKRRLEARI---------- 1731

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEENLK-DQFNYTLSTYEEALKNRENIVSITQQQN 384
                 +LEEE++  +    L     ++ NL+ DQ N  L+      +  EN     ++QN
Sbjct: 1732 ----AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787

Query: 385  EELATQLQQ--------------ALTER-ANMELQLQHAREASQVANEKVQKLE-RLVDV 428
            +EL  +LQ+              AL  + A +E QL +  +  Q A ++V++ E +L DV
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847

Query: 429  L 429
            L
Sbjct: 1848 L 1848



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 66/304 (21%), Positives = 123/304 (40%), Gaps = 34/304 (11%)

Query: 105  SDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTA 164
            SDS   K    L K+   L +  +  Q+ L +E++++  L  KL+  E E  +       
Sbjct: 1292 SDSKSSK----LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS------- 1340

Query: 165  ALVEEVYFAQKERDEAVMSRLQLAIEERDEAIA-RAKHMEMSLKVLENINPEENDMTLQE 223
                  +  Q E +E     L+  I      +A   K ME S+  LE         T +E
Sbjct: 1341 ------FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE---------TAEE 1385

Query: 224  LLNRINNADTGIAIQKNGAIIV-DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQ 282
            +  ++     G++ +    +   D++ KTK    +   + +  L  +R +A +  K+ ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 283  ELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
                + E+   SA           + R  + K LS+ +A E A++Q  +LE      R+ 
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE------RLN 1499

Query: 343  YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANME 402
                  +    + KD    ++   E++ +  E  V   + Q EEL  +LQ     +  +E
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559

Query: 403  LQLQ 406
            + LQ
Sbjct: 1560 VNLQ 1563



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 76/343 (22%), Positives = 149/343 (43%), Gaps = 58/343 (16%)

Query: 123  LRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAA------LVEEVYFAQKE 176
            L+  +++ ++K  +  ++ R+++ +LE + K+    +A +         L   +  A K 
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632

Query: 177  RDEAV--MSRLQLAIEE-----------RDEAIARAKHMEMSLKVLENINPEENDMTLQE 223
            RDEA+  + +LQ  +++           R+E +A+AK  E  LK +E        + LQE
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME-----AEMIQLQE 1687

Query: 224  LLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQE 283
             L     A      Q+    + D I  +        + + +  +EE+    ++  +LE+E
Sbjct: 1688 ELAAAERAKR--QAQQERDELADEIANS--------SGKGALALEEKRRLEARIAQLEEE 1737

Query: 284  LHHVKEQNQTSANNMR---------HLTAENNQERALKAKLLSMQQARETAVQQYK-KLE 333
            L   +EQ  T   N R          +  + N ER+   K  + +Q  E   ++ K KL+
Sbjct: 1738 LE--EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795

Query: 334  EEIQTLRVYY-----SLHKSLSQ-EENLKDQFNYTLSTYEEALKNRENIVSITQQQNEEL 387
            E   T++  Y     +L   ++Q EE L ++     +  ++  +  + +  +  Q ++E 
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855

Query: 388  AT------QLQQALTERANMELQLQHAREASQVANEKVQKLER 424
                    Q  +A T    ++ QL+ A E +Q AN   +KL+R
Sbjct: 1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 46/194 (23%), Positives = 81/194 (41%), Gaps = 12/194 (6%)

Query: 252  KECKMRITAEEMSALIEERDAA---LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQE 308
            +E +M    EE+  + E++ AA   L++ + L+ +L   K Q Q        L AE  + 
Sbjct: 843  QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902

Query: 309  RA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRV--------YYSLHKSLSQEENLKDQF 359
            RA L AK   +++       + ++ EE  Q L+            L + L +EE+ + + 
Sbjct: 903  RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962

Query: 360  NYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
                 T E  LK  E    I + QN +LA + +      A     L    E S+   +  
Sbjct: 963  QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022

Query: 420  QKLERLVDVLRKKV 433
             K E ++  L +++
Sbjct: 1023 NKHEAMITDLEERL 1036


>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
          Length = 284

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)

Query: 118 KELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKER 177
           +EL  L+   K  + +L K  ++ +  + KLEL EK+      +  AAL   +   ++E 
Sbjct: 41  EELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGD-VAALNRRIQLVEEEL 99

Query: 178 DEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIA 236
           D A   RL  A+++ +EA   A   E  +KV+EN    +E  M +QE+  ++  A     
Sbjct: 100 DRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEM--QLKEA----- 151

Query: 237 IQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSAN 296
             K+ A   DR Y+    K+ I   E+    E  + +  KC  LE+EL +V        N
Sbjct: 152 --KHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNV-------TN 202

Query: 297 NMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK 356
           N++                 S++ A E   ++  K EEEI+       L   L + E   
Sbjct: 203 NLK-----------------SLEAASEKYSEKEDKYEEEIKL------LSDKLKEAETRA 239

Query: 357 DQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
           +    T++  E+ + + E  ++  +++N  L   L Q L E
Sbjct: 240 EFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNE 280



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 22/165 (13%)

Query: 269 ERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQ 328
           ++ AA  KCK++E+EL H++++ + + + +   + +          L   Q+  E   ++
Sbjct: 28  DKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSED----------LKDAQEKLELTEKK 77

Query: 329 YKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA 388
               E ++       +L++ +   E   D+    L+T   AL+  E       +    + 
Sbjct: 78  ASDAEGDVA------ALNRRIQLVEEELDRAQERLAT---ALQKLEEAEKAADESERGMK 128

Query: 389 TQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
               +A+ +   ME+Q    +EA  +A E  +K E   +V RK V
Sbjct: 129 VIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYE---EVARKLV 170


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)

Query: 72   DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
            DD++   + E+  ++E R +D+          T+ +++E+    L K  +   +   +L+
Sbjct: 991  DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 132  QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
             +L KE+K   E  KLK KLE    +   +IA+  A + E ++  A+KE + +A ++RL 
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 187  LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
              I +++ A+ + + +E  +  L E+++ E       E   R    D G  ++     + 
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1156

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
            D +  T       T +E+ A  E+    L K    E   H   V+E  Q  A  +  LT 
Sbjct: 1157 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 304  ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
            +  Q +  KA                  +L  + QA++    + KKLE ++Q L+   S 
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 345  -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
                       +HK  ++ E++    N            +++    L++ + ++    +Q
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 384  NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
               ++T+L+Q   ER +++ QL    EA Q     +  L   +   +KK+
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)

Query: 137  EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
            E  E+++ + + +L E ETE +   K  AL      A K++ E  +  L+L    AI+ R
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1640

Query: 193  DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
            +EAI + + ++  +K     LE+     +++  T +E   +  + +  +   +      +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700

Query: 247  RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
            R  K  + +    AEE+++ +  R+A   + +RLE  +  ++E+ +    NM       R
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 300  HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
              T +  Q     A   S  Q  E+A QQ ++  +E+++      LH+    E  +K +F
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1812

Query: 360  NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
              T++  E  +   E  V                        + Q ++E    +  +   
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872

Query: 397  ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
            E+ N     ++ QL+ A E SQ  N   +KL+R +D
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)

Query: 11   SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
            S LE       KS Q  E+L    E      H +  +L  +I  E      ++    Q  
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1095

Query: 68   SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
             +  DDE        +K   +E   +D+  +  +     + ++K+K    L +EL+ L+T
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1153

Query: 126  -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
                   S    Q+  AK ++E   LK  L+ + +  EA++ E   K A  VEE+     
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 174  QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
            Q +R +A + + +  +E+ +  +A               + K +E  ++ L       E 
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 212  INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
               E ND  + +L N + +  TG+  +  G AI + +   +   +++ T E +     ++
Sbjct: 1274 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 271  DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
                +K ++LE+E + +++Q     +   N  RH++  N Q    K KL       E   
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 327  QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
            +  K+ ++EI+ L + Y     +  + E  K++    L      L N+  +VS  +++  
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 386  ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
                +  Q L E  N+  +    R+ ++  A EK  K   L   L +
Sbjct: 1452 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)

Query: 14   EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
            EQE T + K+   + +      + M +K  + V E+T E  E   +   N          
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1223

Query: 74   ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
                   +    +E  + D+  E     Q   + + K+K +   ++EL    +  ++ + 
Sbjct: 1224 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276

Query: 133  KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
            +L   + +  KL+ ++E     L E E +A K+A+  A+L  ++   Q+   E    +L 
Sbjct: 1277 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 187  LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
            ++       EER       DE +   +++E  +  L NI   ++   LQ+  + +   + 
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1392

Query: 234  GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
            G                  + + +   E ++   EE+ AA  K ++ +  L    +    
Sbjct: 1393 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 294  SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
              +N R L +  E  Q +      + K +S + A E    + +  E+E + L +  +L +
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 348  SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
            +L  +E L+       +  E+ + +++++   V   ++    L TQ+++  T+   +E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 405  LQHAREASQVANEKVQKLE 423
            LQ   +A       +Q L+
Sbjct: 1555 LQATEDAKLRLEVNMQALK 1573



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            D + KTKE + +  AE     +E++ + L++ K L QE    + +    A  MR   A  
Sbjct: 859  DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
             QE  L+  L  M+   E    + ++L+ E + + +    L + L +EE  + +      
Sbjct: 917  KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
            T E  +K  E+ + +   QN +L+ + ++ L ER      N+  + + A+  +++ N+  
Sbjct: 975  TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 420  QKLERLVDVLRKK 432
              +  L   L+K+
Sbjct: 1034 SMISELEVRLKKE 1046


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)

Query: 72   DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
            DD++   + E+  ++E R +D+          T+ +++E+    L K  +   +   +L+
Sbjct: 998  DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 132  QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
             +L KE+K   E  KLK KLE    +   +IA+  A + E ++  A+KE + +A ++RL 
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 187  LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
              I +++ A+ + + +E  +  L E+++ E       E   R    D G  ++     + 
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1163

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
            D +  T       T +E+ A  E+    L K    E   H   V+E  Q  A  +  LT 
Sbjct: 1164 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 304  ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
            +  Q +  KA                  +L  + QA++    + KKLE ++Q L+   S 
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 345  -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
                       +HK  ++ E++    N            +++    L++ + ++    +Q
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 384  NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
               ++T+L+Q   ER +++ QL    EA Q     +  L   +   +KK+
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)

Query: 137  EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
            E  E+++ + + +L E ETE +   K  AL      A K++ E  +  L+L    AI+ R
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1647

Query: 193  DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
            +EAI + + ++  +K     LE+     +++  T +E   +  + +  +   +      +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707

Query: 247  RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
            R  K  + +    AEE+++ +  R+A   + +RLE  +  ++E+ +    NM       R
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 300  HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
              T +  Q     A   S  Q  E+A QQ ++  +E+++      LH+    E  +K +F
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1819

Query: 360  NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
              T++  E  +   E  V                        + Q ++E    +  +   
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879

Query: 397  ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
            E+ N     ++ QL+ A E SQ  N   +KL+R +D
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)

Query: 11   SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
            S LE       KS Q  E+L    E      H +  +L  +I  E      ++    Q  
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1102

Query: 68   SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
             +  DDE        +K   +E   +D+  +  +     + ++K+K    L +EL+ L+T
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1160

Query: 126  -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
                   S    Q+  AK ++E   LK  L+ + +  EA++ E   K A  VEE+     
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 174  QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
            Q +R +A + + +  +E+ +  +A               + K +E  ++ L       E 
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 212  INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
               E ND  + +L N + +  TG+  +  G AI + +   +   +++ T E +     ++
Sbjct: 1281 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 271  DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
                +K ++LE+E + +++Q     +   N  RH++  N Q    K KL       E   
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 327  QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
            +  K+ ++EI+ L + Y     +  + E  K++    L      L N+  +VS  +++  
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 386  ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
                +  Q L E  N+  +    R+ ++  A EK  K   L   L +
Sbjct: 1459 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)

Query: 14   EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
            EQE T + K+   + +      + M +K  + V E+T E  E   +   N          
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1230

Query: 74   ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
                   +    +E  + D+  E     Q   + + K+K +   ++EL    +  ++ + 
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283

Query: 133  KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
            +L   + +  KL+ ++E     L E E +A K+A+  A+L  ++   Q+   E    +L 
Sbjct: 1284 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 187  LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
            ++       EER       DE +   +++E  +  L NI   ++   LQ+  + +   + 
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1399

Query: 234  GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
            G                  + + +   E ++   EE+ AA  K ++ +  L    +    
Sbjct: 1400 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 294  SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
              +N R L +  E  Q +      + K +S + A E    + +  E+E + L +  +L +
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 348  SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
            +L  +E L+       +  E+ + +++++   V   ++    L TQ+++  T+   +E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 405  LQHAREASQVANEKVQKLE 423
            LQ   +A       +Q L+
Sbjct: 1562 LQATEDAKLRLEVNMQALK 1580



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            D + KTKE + +  AE     +E++ + L++ K L QE    + +    A  MR   A  
Sbjct: 866  DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
             QE  L+  L  M+   E    + ++L+ E + + +    L + L +EE  + +      
Sbjct: 924  KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
            T E  +K  E+ + +   QN +L+ + ++ L ER      N+  + + A+  +++ N+  
Sbjct: 982  TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 420  QKLERLVDVLRKK 432
              +  L   L+K+
Sbjct: 1041 SMISELEVRLKKE 1053


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)

Query: 72   DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
            DD++   + E+  ++E R +D+          T+ +++E+    L K  +   +   +L+
Sbjct: 998  DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 132  QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
             +L KE+K   E  KLK KLE    +   +IA+  A + E ++  A+KE + +A ++RL 
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 187  LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
              I +++ A+ + + +E  +  L E+++ E       E   R    D G  ++     + 
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1163

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
            D +  T       T +E+ A  E+    L K    E   H   V+E  Q  A  +  LT 
Sbjct: 1164 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 304  ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
            +  Q +  KA                  +L  + QA++    + KKLE ++Q L+   S 
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 345  -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
                       +HK  ++ E++    N            +++    L++ + ++    +Q
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 384  NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
               ++T+L+Q   ER +++ QL    EA Q     +  L   +   +KK+
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)

Query: 137  EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
            E  E+++ + + +L E ETE +   K  AL      A K++ E  +  L+L    AI+ R
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1647

Query: 193  DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
            +EAI + + ++  +K     LE+     +++  T +E   +  + +  +   +      +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707

Query: 247  RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
            R  K  + +    AEE+++ +  R+A   + +RLE  +  ++E+ +    NM       R
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 300  HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
              T +  Q     A   S  Q  E+A QQ ++  +E+++      LH+    E  +K +F
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1819

Query: 360  NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
              T++  E  +   E  V                        + Q ++E    +  +   
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879

Query: 397  ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
            E+ N     ++ QL+ A E SQ  N   +KL+R +D
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)

Query: 11   SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
            S LE       KS Q  E+L    E      H +  +L  +I  E      ++    Q  
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1102

Query: 68   SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
             +  DDE        +K   +E   +D+  +  +     + ++K+K    L +EL+ L+T
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1160

Query: 126  -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
                   S    Q+  AK ++E   LK  L+ + +  EA++ E   K A  VEE+     
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 174  QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
            Q +R +A + + +  +E+ +  +A               + K +E  ++ L       E 
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 212  INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
               E ND  + +L N + +  TG+  +  G AI + +   +   +++ T E +     ++
Sbjct: 1281 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 271  DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
                +K ++LE+E + +++Q     +   N  RH++  N Q    K KL       E   
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 327  QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
            +  K+ ++EI+ L + Y     +  + E  K++    L      L N+  +VS  +++  
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 386  ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
                +  Q L E  N+  +    R+ ++  A EK  K   L   L +
Sbjct: 1459 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)

Query: 14   EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
            EQE T + K+   + +      + M +K  + V E+T E  E   +   N          
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1230

Query: 74   ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
                   +    +E  + D+  E     Q   + + K+K +   ++EL    +  ++ + 
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283

Query: 133  KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
            +L   + +  KL+ ++E     L E E +A K+A+  A+L  ++   Q+   E    +L 
Sbjct: 1284 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 187  LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
            ++       EER       DE +   +++E  +  L NI   ++   LQ+  + +   + 
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1399

Query: 234  GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
            G                  + + +   E ++   EE+ AA  K ++ +  L    +    
Sbjct: 1400 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441

Query: 294  SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
              +N R L +  E  Q +      + K +S + A E    + +  E+E + L +  +L +
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 348  SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
            +L  +E L+       +  E+ + +++++   V   ++    L TQ+++  T+   +E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 405  LQHAREASQVANEKVQKLE 423
            LQ   +A       +Q L+
Sbjct: 1562 LQATEDAKLRLEVNMQALK 1580



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            D + KTKE + +  AE     +E++ + L++ K L QE    + +    A  MR   A  
Sbjct: 866  DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
             QE  L+  L  M+   E    + ++L+ E + + +    L + L +EE  + +      
Sbjct: 924  KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
            T E  +K  E+ + +   QN +L+ + ++ L ER      N+  + + A+  +++ N+  
Sbjct: 982  TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040

Query: 420  QKLERLVDVLRKK 432
              +  L   L+K+
Sbjct: 1041 SMISELEVRLKKE 1053


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)

Query: 72   DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
            DD++   + E+  ++E R +D+          T+ +++E+    L K  +   +   +L+
Sbjct: 991  DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 132  QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
             +L KE+K   E  KLK KLE    +   +IA+  A + E ++  A+KE + +A ++RL 
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 187  LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
              I +++ A+ + + +E  +  L E+++ E       E   R    D G  ++     + 
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1156

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
            D +  T       T +E+ A  E+    L K    E   H   V+E  Q  A  +  LT 
Sbjct: 1157 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 304  ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
            +  Q +  KA                  +L  + QA++    + KKLE ++Q L+   S 
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 345  -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
                       +HK  ++ E++    N            +++    L++ + ++    +Q
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 384  NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
               ++T+L+Q   ER +++ QL    EA Q     +  L   +   +KK+
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)

Query: 137  EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
            E  E+++ + + +L E ETE +   K  AL      A K++ E  +  L+L    AI+ R
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1640

Query: 193  DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
            +EAI + + ++  +K     LE+     +++  T +E   +  + +  +   +      +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700

Query: 247  RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
            R  K  + +    AEE+++ +  R+A   + +RLE  +  ++E+ +    NM       R
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 300  HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
              T +  Q     A   S  Q  E+A QQ ++  +E+++      LH+    E  +K +F
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1812

Query: 360  NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
              T++  E  +   E  V                        + Q ++E    +  +   
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872

Query: 397  ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
            E+ N     ++ QL+ A E SQ  N   +KL+R +D
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)

Query: 11   SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
            S LE       KS Q  E+L    E      H +  +L  +I  E      ++    Q  
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1095

Query: 68   SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
             +  DDE        +K   +E   +D+  +  +     + ++K+K    L +EL+ L+T
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1153

Query: 126  -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
                   S    Q+  AK ++E   LK  L+ + +  EA++ E   K A  VEE+     
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 174  QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
            Q +R +A + + +  +E+ +  +A               + K +E  ++ L       E 
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 212  INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
               E ND  + +L N + +  TG+  +  G AI + +   +   +++ T E +     ++
Sbjct: 1274 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 271  DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
                +K ++LE+E + +++Q     +   N  RH++  N Q    K KL       E   
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 327  QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
            +  K+ ++EI+ L + Y     +  + E  K++    L      L N+  +VS  +++  
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 386  ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
                +  Q L E  N+  +    R+ ++  A EK  K   L   L +
Sbjct: 1452 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)

Query: 14   EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
            EQE T + K+   + +      + M +K  + V E+T E  E   +   N          
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1223

Query: 74   ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
                   +    +E  + D+  E     Q   + + K+K +   ++EL    +  ++ + 
Sbjct: 1224 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276

Query: 133  KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
            +L   + +  KL+ ++E     L E E +A K+A+  A+L  ++   Q+   E    +L 
Sbjct: 1277 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 187  LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
            ++       EER       DE +   +++E  +  L NI   ++   LQ+  + +   + 
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1392

Query: 234  GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
            G                  + + +   E ++   EE+ AA  K ++ +  L    +    
Sbjct: 1393 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434

Query: 294  SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
              +N R L +  E  Q +      + K +S + A E    + +  E+E + L +  +L +
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 348  SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
            +L  +E L+       +  E+ + +++++   V   ++    L TQ+++  T+   +E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 405  LQHAREASQVANEKVQKLE 423
            LQ   +A       +Q L+
Sbjct: 1555 LQATEDAKLRLEVNMQALK 1573



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            D + KTKE + +  AE     +E++ + L++ K L QE    + +    A  MR   A  
Sbjct: 859  DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
             QE  L+  L  M+   E    + ++L+ E + + +    L + L +EE  + +      
Sbjct: 917  KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
            T E  +K  E+ + +   QN +L+ + ++ L ER      N+  + + A+  +++ N+  
Sbjct: 975  TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033

Query: 420  QKLERLVDVLRKK 432
              +  L   L+K+
Sbjct: 1034 SMISELEVRLKKE 1046


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 75/301 (24%), Positives = 146/301 (48%), Gaps = 32/301 (10%)

Query: 119  ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
            ELD++   ++K  + L  E +++++   +LE+     E  + EK    V+      KE+ 
Sbjct: 2384 ELDVVTIRSEK--ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ-----MKEKS 2436

Query: 179  EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE-NINPEENDMTLQ--ELLNRINNADTG- 234
               M  LQ  ++E +E +A   + + + K  E N++ +   + L+  +LL  ++ A    
Sbjct: 2437 STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNY 2496

Query: 235  IAIQKNGAIIVDRIYKTKECKMRITAEEMSAL---IEERDAALSKCKRLEQELHHVKEQN 291
            I +Q +   ++  +   K+ K+    EE+S L   I++++  +SK  ++E E    KEQN
Sbjct: 2497 IVLQSSVNGLIQEVEDGKQ-KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN 2555

Query: 292  QTSANNMRHLTAENNQE-RALKAKLLSMQQARETAVQQYKKLEEEIQTLRV-----YYSL 345
                  +R+LT E  Q+ + L++K  S+Q   E     YK LE E++  ++        +
Sbjct: 2556 L----ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611

Query: 346  HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
            +K  ++E  L+ +       +E A K  E    ++ ++N  LA +LQ  L E  + + QL
Sbjct: 2612 NKMTAKETELQREM------HEMAQKTAELQEELSGEKN-RLAGELQLLLEEIKSSKDQL 2664

Query: 406  Q 406
            +
Sbjct: 2665 K 2665



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 66/340 (19%), Positives = 164/340 (48%), Gaps = 35/340 (10%)

Query: 120  LDILRTSNKKLQQKLAKEDKEQRKLKFK----------LELQEKET-----EAK-----I 159
            +++L+T  K+L +++A    +Q   K K          LEL++ +      EAK     +
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499

Query: 160  AEKTAALVEEVYFAQK--ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN 217
                  L++EV   ++  E+ +  +SRL+  I+++++ +++   +E   ++ +  N E  
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559

Query: 218  DMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC 277
            ++T+ EL  +I    +  A  ++   ++   YK  E ++ +T  +  + +E+ +   +K 
Sbjct: 2560 NLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618

Query: 278  KRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQ 337
              L++E+H   E  Q +A     L+ E N+   L  +L  + +  +++  Q K+L  E  
Sbjct: 2619 TELQREMH---EMAQKTAELQEELSGEKNR---LAGELQLLLEEIKSSKDQLKELTLENS 2672

Query: 338  TLRVYYS-LHK-SLSQEENLKDQF-NYTLSTYEEALKNRENIVSITQQQNEELATQLQQA 394
             L+     +HK  + +E  ++++   Y L  +E   K++  ++   +Q   E+ T  ++ 
Sbjct: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732

Query: 395  LTER---ANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
             ++    ++ +L++   + + +  N  ++   ++++ L+K
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 93/454 (20%), Positives = 176/454 (38%), Gaps = 59/454 (12%)

Query: 6   KDITHSYL--EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTN 63
           +D + SY   EQE T  ++ST    +   NS    +  S  L++++  +N E   +   N
Sbjct: 239 RDFSASYFSGEQEVTP-SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL--RNKIN 295

Query: 64  FQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDIL 123
              +     ++ +     K+  ++ +      E +   +V +    E  +     + D  
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE--LVRTTAQYDQA 353

Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            T    L+QKL K  ++    +   E      E KI EK     EE+   Q+        
Sbjct: 354 STKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413

Query: 184 RLQLAIEERDEAIARAKHMEMSLKV-LENINPEENDM--TLQELLNRINNADTGIAIQKN 240
            +Q+      E + +AK+M   L+  L+ +   +  +   L+E   ++  A+      + 
Sbjct: 414 CIQMKARLTQE-LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ- 471

Query: 241 GAIIVDRIYKTKECKMRITAEEM----SALIEERDAALSKCKRLEQELHHVKEQNQTSAN 296
                      KE ++R + EEM    + L    +    +   LE EL ++K+    S N
Sbjct: 472 ----------IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521

Query: 297 NMRHLTAENNQERA--------------------LKAKLLSMQQARETAVQQYKKLEEEI 336
               + A+N  +                      LK  +  +++ R+ +    KK E  I
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHI 581

Query: 337 QTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALT 396
           + L     L K+  + + L          YEE LK  + + S  + +NE+L TQ++   +
Sbjct: 582 EQLND--KLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCWKSENEKLLTQME---S 635

Query: 397 ERANMELQLQHAREA-------SQVANEKVQKLE 423
           E+ N++ ++ H           S   NE+V+ LE
Sbjct: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 68/325 (20%), Positives = 145/325 (44%), Gaps = 39/325 (12%)

Query: 118  KELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKER 177
            +E+  LR   +KL+ ++  ++K+Q  +  KL+ +E+E ++ + +K   L  E+  ++ E 
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS-LKDKVENLERELQMSE-EN 2169

Query: 178  DEAVMSRLQLAIEERDEAIARAKHMEMSLKVLE----NINPEENDMT--LQELLNRINNA 231
             E V+   + +  E +    + + M  SLKV E     +  E+ ++T  +QE   +++  
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSA-------LIEERDAALSKCKRLEQEL 284
            D  ++  K+       + + ++ +++I  E  +A       L E  +A  + C   +QE+
Sbjct: 2230 DKLLSSFKS------LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG--DQEI 2281

Query: 285  HHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS 344
                EQ+        H     N    L+A+L + ++ +   +QQ K+ E     L+    
Sbjct: 2282 MKATEQSLDPPIEEEHQL--RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK---- 2335

Query: 345  LHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQ 404
                  + ENL+ +     +  E A    EN    ++ + E L  +++        +EL 
Sbjct: 2336 -----GRVENLERELEIARTNQEHAALEAEN----SKGEVETLKAKIEGMTQSLRGLELD 2386

Query: 405  LQHAR-EASQVANEKVQKLERLVDV 428
            +   R E   + NE  ++ ER+ ++
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISEL 2411



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 107/489 (21%), Positives = 203/489 (41%), Gaps = 61/489 (12%)

Query: 1    MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSE-----KSMHRKSTELVN------EI 49
            +EN  +++  S   QE   ++      E  T+ ++     +S+     +LV        +
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215

Query: 50   TCENTEWPGQRSTNFQIISSYP------DDESVYCTTEKYNVMEHRHNDMHYECMTPCQV 103
            T +  E  GQ S   +++SS+       +   +    E    +E   N +         +
Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275

Query: 104  TSDSD----KEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKI 159
              D +     E+++   ++E   LR S +KL+ +L  ++K+Q  L    +L+E E  A +
Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ--LCVLQQLKESEHHADL 2333

Query: 160  AE-KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLE----NINP 214
             + +   L  E+  A+  ++ A +   + +  E +   A+ + M  SL+ LE     I  
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392

Query: 215  EENDMT--LQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRI-TAEEMSAL----I 267
            E+ ++T  LQ+   RI+  +   +  +N  I+ ++  +  + K +  TA EM       +
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFEN--ILQEKEQEKVQMKEKSSTAMEMLQTQLKEL 2450

Query: 268  EERDAALSKCKRLEQELHHVKEQNQTS---------ANNMRHLTAENNQERALKAKLLSM 318
             ER AAL      +QE    KEQN +S         A  ++ L    N    L++ +  +
Sbjct: 2451 NERVAALHN----DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506

Query: 319  QQARETAVQQYKKLEEEIQTLRVYYS----LHKSLSQ---EENLKDQFNYTLSTYEEALK 371
             Q  E   Q+ +K +EEI  L+        L   LSQ   E  L  + N  L      L+
Sbjct: 2507 IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566

Query: 372  NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
             +   + + Q +N  L   L+   +   N+E +L+  +       EKV K+      L++
Sbjct: 2567 QK---IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623

Query: 432  KVGTGTMRT 440
            ++     +T
Sbjct: 2624 EMHEMAQKT 2632



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 58/297 (19%), Positives = 121/297 (40%), Gaps = 43/297 (14%)

Query: 128 KKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL 187
           ++L  KL+K +KE + L   LEL++KE E    EKT      ++   K  +E ++++++ 
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT------LFSCWKSENEKLLTQME- 634

Query: 188 AIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDR 247
              E++   ++  H+E  LK  +  + E N+      ++R           +N ++ +  
Sbjct: 635 --SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR-----------ENLSVEIRN 681

Query: 248 IYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE-NN 306
           ++   + K      +  A +E           L+Q+     +++Q    NM   T++   
Sbjct: 682 LHNVLDSKSVEVETQKLAYME-----------LQQKAEFSDQKHQKEIENMCLKTSQLTG 730

Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           Q   L+ KL  +        + Y+ L  E ++LR    L KS        +    +L  +
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR---DLLKSKDASLVTNEDHQRSLLAF 787

Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLE 423
           ++      +  +I  +Q            +ER+   L+   + + S +   +V  LE
Sbjct: 788 DQQPAMHHSFANIIGEQG--------SMPSERSECRLEADQSPKNSAILQNRVDSLE 836



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 63/362 (17%), Positives = 144/362 (39%), Gaps = 25/362 (6%)

Query: 80   TEKYNVME-HRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKED 138
            TE+  + E  + N +  + +   Q+ S+     T++   KE+  + + NK+  ++L +E+
Sbjct: 922  TEQAEIQELKKSNHLLEDSLKELQLLSE-----TLSLEKKEMSSIISLNKREIEELTQEN 976

Query: 139  KEQRKLKFKLE------LQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL---AI 189
               +++   L       +Q+ E+ A   ++    + E+    K+    ++ R +    A 
Sbjct: 977  GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036

Query: 190  EERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIY 249
            E+  +    A+     L+ L N    E     +   N +       A +    +      
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLN----ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1092

Query: 250  KTKECKMRITAEEM-----SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
            + +   + +  E +     S + + ++ + S+   L+QE+  +KE+       +  L  E
Sbjct: 1093 EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152

Query: 305  NNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLS 364
            N Q   +       Q      ++   K E E +  +  +     L  +E   D +N  L 
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVK-ERESERNQCNFKPQMDLEVKEISLDSYNAQLV 1211

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLER 424
              E  L+N+E  +  ++++ E L  +LQ    +     LQ   ++E S + + ++   E+
Sbjct: 1212 QLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEK 1271

Query: 425  LV 426
             +
Sbjct: 1272 YI 1273



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 68/325 (20%), Positives = 139/325 (42%), Gaps = 41/325 (12%)

Query: 119  ELDILRTSNKKLQQKLAKEDK---------EQRKLKFKLELQEKETEAKIAEKTAALVEE 169
            +L +  TSN+ L+     ED+         E ++L  KL LQE +   KI  +    +E+
Sbjct: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKI--EACIELEK 1830

Query: 170  VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRIN 229
            +    K+ +  +  +L+    +  E + R       ++  E +N +     L+   ++ +
Sbjct: 1831 IVGELKKENSDLSEKLEYFSCDHQELLQR-------VETSEGLNSD-----LEMHADKSS 1878

Query: 230  NADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMS----ALIEERDAALSKCKRLEQELH 285
              D G  + K      +R    +    RI +E+ S    AL  E D  + + ++L  E  
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938

Query: 286  HVKEQNQTSA--NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY 343
            +  +Q         +  +T+E NQ   L+ +L +M +      Q  +K++E+ Q L  + 
Sbjct: 1939 NENKQKVIVCLEEELSVVTSERNQ---LRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995

Query: 344  S--LHKSLSQEENLKD--QFNYTLST-YEEALKNRENIVSITQQQNEELATQLQQALTER 398
            S  LH     E  +K+  +   TLS+   E LK++ ++    Q++ + L    Q     +
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL----QEKLQSLEKDSQALSLTK 2051

Query: 399  ANMELQLQHAREASQVANEKVQKLE 423
              +E Q+    +  ++  ++ + L+
Sbjct: 2052 CELENQIAQLNKEKELLVKESESLQ 2076



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 26/141 (18%), Positives = 67/141 (47%), Gaps = 6/141 (4%)

Query: 291 NQTSANNMRHLTAENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLH 346
           N +S + +  L A+N + R     L+ +L   ++  +  V ++++L+ +++  +V   L 
Sbjct: 273 NSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV--ELI 330

Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
           +        +D+   T + Y++A      +    ++  E+L+ Q Q A + R ++E +++
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390

Query: 407 HAREASQVANEKVQKLERLVD 427
              +  Q    + Q+  + +D
Sbjct: 391 EKEKEFQEELSRQQRSFQTLD 411



 Score = 30.8 bits (68), Expect = 2.6
 Identities = 43/202 (21%), Positives = 82/202 (40%), Gaps = 32/202 (15%)

Query: 13   LEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPD 72
            L++E +G       + QL +   KS    S + + E+T EN+E   ++S +         
Sbjct: 2635 LQEELSGEKNRLAGELQLLLEEIKS----SKDQLKELTLENSEL--KKSLDCMHKDQVEK 2688

Query: 73   DESVYCTTEKYNVMEHRHNDMH----------YECMTPCQVTSDSDKEKTIAFLLKELDI 122
            +  V     +Y +  H     H          YE          + KE+ ++    E+D+
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748

Query: 123  LRTSNKKLQQKLAKEDKEQRKLK------------FKLELQEKETEAKIAEKTAALVEEV 170
            L++S ++L   L    +   +LK             K E +  + + K+  K+   +EE 
Sbjct: 2749 LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE- 2807

Query: 171  YFAQKERDEAVMSRLQLAIEER 192
               +KE  +  +S+LQ A E++
Sbjct: 2808 ---EKEILQKELSQLQAAQEKQ 2826


>gi|122937396 coiled-coil domain containing 150 [Homo sapiens]
          Length = 1101

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 68/320 (21%), Positives = 144/320 (45%), Gaps = 25/320 (7%)

Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAI 189
           L+++LAK   +   L   L+  E+E +  +A++ A+L  E+     +       +++   
Sbjct: 495 LEKELAKNKVDINTLTHNLQTLEEENK-HLADQMASL--ELQQVTSDYHGLAQQKVEKIT 551

Query: 190 EERDEAIARAKHMEMSLKVLENINPEENDMTLQ-ELLNRINNADTGIAIQKNGAIIVDRI 248
           E +++       +++ +K LE       D +LQ + L ++N        Q N  +   R+
Sbjct: 552 ESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRV 611

Query: 249 Y------KTKECK--MRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
           +        KE K  +  + EE+S  ++ R+AAL + ++L+++L  V+++      N + 
Sbjct: 612 HLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQR 671

Query: 301 LTAENNQERALKAKLL--------SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE 352
             AE  ++      +L         MQ A E    +  + + EI  L+    L++   Q+
Sbjct: 672 QLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQK 731

Query: 353 -ENLKDQFNYTLSTYEE----ALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
            E   DQ+   +   E+     +++ +  + + ++ N +LA  L+QAL    +++ +L H
Sbjct: 732 LEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDH 791

Query: 408 AREASQVANEKVQKLERLVD 427
            +E  +    + Q LE   D
Sbjct: 792 IQEQLESKELERQNLETFKD 811



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 71/327 (21%), Positives = 133/327 (40%), Gaps = 56/327 (17%)

Query: 106 DSDKEKTIAFLLKEL------DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKI 159
           D D +K I+ +  E       DIL  + + L  ++ + +   + LK  +   + E +   
Sbjct: 70  DLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLN- 128

Query: 160 AEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME-MSLKVLENINPEEND 218
            +KTA L + +                 AI+E      +  H+E M+L+       EE D
Sbjct: 129 PQKTAFLKDRLN----------------AIQEEHSKDLKLLHLEVMNLRQQLRAVKEEED 172

Query: 219 MTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCK 278
               E+             +KN AII + + KT + KM +  +E+              +
Sbjct: 173 KAQDEVQRLTATLKIASQTKKNAAIIEEEL-KTTKRKMNLKIQELR-------------R 218

Query: 279 RLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQT 338
           +L QE  +++E  + SA+             A+  K+  M    E   +Q   L++    
Sbjct: 219 QLAQE-KYLRESLEKSAS-------------AMLLKIQEMGSTVEVERKQVHILQQNCIA 264

Query: 339 LR-VYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
           LR    S  + L+QE+  K++     S  +  L +R++++S   ++N+ L     +   E
Sbjct: 265 LRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEE 324

Query: 398 RANME---LQLQHAREASQVANEKVQK 421
            A +    + L  A E +QV N+++ K
Sbjct: 325 NAYLRSEIMSLHEASEKAQVLNDQLTK 351



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 73/362 (20%), Positives = 151/362 (41%), Gaps = 81/362 (22%)

Query: 120 LDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFA------ 173
           L I     +  Q+K  +E  E+      L++QE  +  ++  K   ++++   A      
Sbjct: 211 LKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQ 270

Query: 174 -----------QKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ 222
                      +KE  E   S+L+  +  RD+ I++      +L++  N   EEN     
Sbjct: 271 SAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRS 330

Query: 223 ELLNRINNADTGIAI-------------------QKNGAIIVDR--IYKTKECKMRITAE 261
           E+++    ++    +                    +   II D   I + ++  M  T +
Sbjct: 331 EIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQ 390

Query: 262 EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ----------ERAL 311
           E + L++   A+++       EL  V+ +      ++ HL  E+NQ            A+
Sbjct: 391 EQNLLLDAAHASIT------NELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAV 444

Query: 312 KAKLLSMQQAR-----ETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           + +LL    AR     E ++Q+ K L EE    +  +    + +++E ++++ N      
Sbjct: 445 QKELLESTIARLRGELEASMQEKKSLLEE----KERFQREVNKTEKEIVQERCNLE---- 496

Query: 367 EEALKNRENIVSIT------QQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420
           +E  KN+ +I ++T      +++N+ LA Q+       A++ELQ Q   +   +A +KV+
Sbjct: 497 KELAKNKVDINTLTHNLQTLEEENKHLADQM-------ASLELQ-QVTSDYHGLAQQKVE 548

Query: 421 KL 422
           K+
Sbjct: 549 KI 550



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 41/204 (20%), Positives = 92/204 (45%), Gaps = 17/204 (8%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I  L K+    R + KK+ Q+   E K+         ++   T  ++ +K A L E++  
Sbjct: 828  IEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAEL-EKILE 886

Query: 173  AQKERDEAVMSRLQLAIEERD---EAIARAKHMEMSLKVLENINPE------ENDMTLQE 223
            + KE+ +   ++++L +  +    + I R K +E  LK +E I  +      E  +++Q 
Sbjct: 887  SNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQR 946

Query: 224  LLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQE 283
             +  + N    + +        D   + K+ ++ + AE      + R    ++C+ LE+ 
Sbjct: 947  FVCEMTNLQKEMQMLAKSQY--DASVRNKQQELHLEAER-----KIRQELENRCQELEET 999

Query: 284  LHHVKEQNQTSANNMRHLTAENNQ 307
            + H+K+  + + N ++  + E+ Q
Sbjct: 1000 VRHLKKCKEATENTLKEASVESEQ 1023



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 70/358 (19%), Positives = 141/358 (39%), Gaps = 67/358 (18%)

Query: 123 LRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVM 182
           L+ S K  +   A ED+E +K+      Q +  EAK       ++ E   A   + +  +
Sbjct: 645 LKESQKLKEDLEAVEDRENKKVG---NFQRQLAEAKEDNCKVTIMLENVLASHSKMQGAL 701

Query: 183 SRLQLAIEERDEAIARAK-HMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNG 241
            ++Q+ +  RD  IA  K   +++ + ++ +  E +    + L+    +     ++QK  
Sbjct: 702 EKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQK-- 759

Query: 242 AIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
                         + +  E+   L    + AL     L+ +L H++EQ ++     ++L
Sbjct: 760 -------------ALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNL 806

Query: 302 -------TAENNQERALKAKLLS-----MQQARETA-------VQQYKKLEEE-----IQ 337
                  T E+  E  L A+ +       Q  RET        V + KK  +E     ++
Sbjct: 807 ETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVE 866

Query: 338 TLRVYYSLHKSL--------SQEENLKDQFNY----------------TLSTYEEALKNR 373
             R    L + L        S +E +K+Q                    +   E+ LK  
Sbjct: 867 VSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQM 926

Query: 374 ENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
           E I    Q++N E +  +Q+ + E  N++ ++Q   ++   A+ + ++ E  ++  RK
Sbjct: 927 ELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERK 984



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 71/324 (21%), Positives = 125/324 (38%), Gaps = 77/324 (23%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I  L K L + R  N+KL   L +  +    L+ KL+  +++ E+K              
Sbjct: 754  IESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESK-------------- 799

Query: 173  AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
             + ER      + ++  E + EA   A+ +E   K  +         T +E         
Sbjct: 800  -ELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQ---------TERE--------- 840

Query: 233  TGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEE--RDAALSKCKR-LEQELHHVKE 289
                              TK+   R  AE   AL E   R   +S+  R L Q+L  +++
Sbjct: 841  -----------------TTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEK 883

Query: 290  QNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSL 349
              +++   ++      NQ+  +K  L     A+    Q  +++++          + K L
Sbjct: 884  ILESNKEKIK------NQKTQIKLHL----SAKANNAQNIERMKQ----------IEKEL 923

Query: 350  SQEENLKDQFNYTLSTYEEALKNRENIVSIT--QQQNEELATQLQQALTERANMELQLQH 407
             Q E +KDQ  Y    YE++L  +  +  +T  Q++ + LA     A       EL L+ 
Sbjct: 924  KQMELIKDQ--YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEA 981

Query: 408  AREASQVANEKVQKLERLVDVLRK 431
             R+  Q    + Q+LE  V  L+K
Sbjct: 982  ERKIRQELENRCQELEETVRHLKK 1005


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)

Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
           ++   + K  Q+++ K++ EQ   + K++LQE     +E ++ I ++TA        ++ 
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
            + A++   +++ S+L   +  + +   R   M++     + +N EE+  M +Q++L + 
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578

Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
                 I    + IA Q + +++ + ++K    K +   +   +L  ERD   SK    E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634

Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
           +EL  ++  N      ++ L A  N++ A   +L  MQQ+      + + LEE++Q    
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690

Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
            + +   + + + L DQ N  L +  + L+       +++Q N+++  Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)

Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
           +D+L+  +  +Q  L K  K        Q + K KL    KE  A   ++   L +E+  
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363

Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
            +KER   V++R++    +R   + +  ++  +   +     ++  M  Q++  ++  A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418

Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
                Q+NG +        +++   +  ++    ++ + L+ E      K  +L+QE   
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475

Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
            K   Q +      L  AE   E     ++ +    + A++    ++   E E+Q+L  +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533

Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
             L  +L  ++ L+ +    + + ++ +   E++    Q   +QNE L  Q+QQ  ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593

Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
                   A E  +V  EK +++++  D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 88/414 (21%), Positives = 173/414 (41%), Gaps = 48/414 (11%)

Query: 28   EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
            E +    E  +  K T+L+ ++  EN  +  Q    +  N+Q  SS+P  E +    +E+
Sbjct: 923  EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 981

Query: 83   YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
               +    N++    + +   +  ++  +EK      + ++ L ++ K LQ K+ K  KE
Sbjct: 982  EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1037

Query: 141  QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
            +++    +EL+ KE   K+  K +      Y       E          ++  E +A   
Sbjct: 1038 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1087

Query: 201  HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
              E  +KVLE+   E ++M TL +L     +   A+T   +QK     + R  + +E K 
Sbjct: 1088 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1141

Query: 257  RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMR---HLTAENNQERALKA 313
            ++  +E    I++  ++ +     EQEL  ++ +N+   N  R   HL  E   E+A   
Sbjct: 1142 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRREREHL--EMELEKAEME 1196

Query: 314  KLLSMQQARETAVQQYKKL----EEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEA 369
            +   + + RE   Q  + L     E+ +  +V   LHK+    E ++ +     +     
Sbjct: 1197 RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI-VKAAGDTTV 1255

Query: 370  LKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLE 423
            ++N +        + E ++  L Q +T+   ++  LQ   +      E  Q LE
Sbjct: 1256 IENSDVSPETESSEKETMSVSLNQTVTQ---LQQLLQAVNQQLTKEKEHYQVLE 1306



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 78/371 (21%), Positives = 152/371 (40%), Gaps = 80/371 (21%)

Query: 85   VMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLK-----------ELDILRTSNKKLQQK 133
            V E  + D+  E M  C +    +K KT+  LL+           EL+ +RT N  L + 
Sbjct: 721  VSEQPNKDV-VEQMEKC-IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK- 777

Query: 134  LAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERD 193
                           E+Q+ + +       A+LVEE+     E+D  + S  +L   E  
Sbjct: 778  ---------------EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822

Query: 194  EAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKE 253
            +   + K +++S+              +QEL N +   +  +   K        + + KE
Sbjct: 823  KVANKEKTVQLSI-----------TSKVQELQNLLKGKEEQMNTMK-------AVLEEKE 864

Query: 254  CKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKA 313
              +  T + +  L EE ++  +  + + Q  H++KE   +SA+    L     ++     
Sbjct: 865  KDLANTGKWLQDLQEENESLKAHVQEVAQ--HNLKE--ASSASQFEELEIVLKEKENELK 920

Query: 314  KLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY----TLSTYEEA 369
            +L +M + RE+ +    +L +++Q     +      SQ E LK Q NY    +   +EE 
Sbjct: 921  RLEAMLKERESDLSSKTQLLQDVQDENKLFK-----SQIEQLKQQ-NYQQASSFPPHEEL 974

Query: 370  LK-----------------NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREAS 412
            LK                 + ++ V   +++N +L  +  +A+   A+ E  LQ   + +
Sbjct: 975  LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD--KVN 1032

Query: 413  QVANEKVQKLE 423
            + + E+ Q++E
Sbjct: 1033 KTSKERQQQVE 1043



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)

Query: 84  NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
           +V E +  +   + +   QV  +SD  K     ++ + + +      +   +K+   Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169

Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
            K   + Q+K+              E      +R EA    L L  E + E+ +  K   
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212

Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
              +  EN+  +E  +     +  ++NAD+   + K   I       V+ I K+   K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272

Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
              ++ +A ++ +D  LS    +  E      +  +KE     Q+    ++   LT   +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332

Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           Q +     L ++++       + K+L +E+ T +      +S      +KD+    + T 
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383

Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
           E+     +N + ++ Q+ +++  + QQ    R  ME ++ H ++ + +  + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)

Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
           E D+  A  K  +  L +   +  E+  + + +LL            +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321

Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
           + + ++     ++       +A+ E+  A   +CK+L QE+   KE++      M+    
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381

Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
              +E  +       Q     + Q+ ++++ + Q +R       +  ++EN  L+D  + 
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435

Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
           T +  E       N +   +Q    L  +L +   +    E+Q ++A +A+     ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492

Query: 422 LER 424
            ER
Sbjct: 493 AER 495



 Score = 32.3 bits (72), Expect = 0.88
 Identities = 73/379 (19%), Positives = 158/379 (41%), Gaps = 60/379 (15%)

Query: 109  KEKTIAFLLKELDILRTSNKK--LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
            K K++  LL E ++L+ +NK+  +Q  +  + +E + L    E Q    +A + EK   L
Sbjct: 809  KIKSVEELL-EAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 867

Query: 167  VEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQE 223
                 + Q  +E +E++ + +Q +A     EA + ++  E+ + + E    +EN++   E
Sbjct: 868  ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KENELKRLE 923

Query: 224  LLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSALIEERDA 272
             + +   +D          +Q    +   +I + K+   +  +     EE+  +I ER+ 
Sbjct: 924  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 983

Query: 273  ALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQ 327
             +S    +   L+  + H  K+ N     N   + A  + E+ L+ K+    + R+  V+
Sbjct: 984  EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1043

Query: 328  QYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EENLK--D 357
              + + +E ++ L    S+  +LS                            E  LK  D
Sbjct: 1044 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1103

Query: 358  QFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQ 413
            + +  L      Y+  L   E I+   Q+  E+   + +  + E      Q+Q +  +S+
Sbjct: 1104 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1163

Query: 414  VANEKVQKLERLVDVLRKK 432
               E+++   + ++ LR++
Sbjct: 1164 QELERLRSENKDIENLRRE 1182


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)

Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
           ++   + K  Q+++ K++ EQ   + K++LQE     +E ++ I ++TA        ++ 
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
            + A++   +++ S+L   +  + +   R   M++     + +N EE+  M +Q++L + 
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578

Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
                 I    + IA Q + +++ + ++K    K +   +   +L  ERD   SK    E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634

Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
           +EL  ++  N      ++ L A  N++ A   +L  MQQ+      + + LEE++Q    
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690

Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
            + +   + + + L DQ N  L +  + L+       +++Q N+++  Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 87/405 (21%), Positives = 174/405 (42%), Gaps = 62/405 (15%)

Query: 28   EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
            E +    E  +  K T+L+ ++  EN  +  Q    +  N+Q  SS+P  E +    +E+
Sbjct: 946  EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004

Query: 83   YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
               +    N++    + +   +  ++  +EK      + ++ L ++ K LQ K+ K  KE
Sbjct: 1005 EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1060

Query: 141  QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
            +++    +EL+ KE   K+  K +      Y       E          ++  E +A   
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1110

Query: 201  HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
              E  +KVLE+   E ++M TL +L     +   A+T   +QK     + R  + +E K 
Sbjct: 1111 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1164

Query: 257  RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
            ++  +E    I++  ++ +     EQEL  ++ +N+   N  R       +   L+ +L 
Sbjct: 1165 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRR-------EREHLEMELE 1214

Query: 317  SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENI 376
              +  R T V + ++L++ +  L            ++ L D       +Y EA++  E +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTEL------------QKKLDD-------SYSEAVRQNEEL 1255

Query: 377  VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
              +  Q NE L T+L+    ER  +   L  A+++ ++   K+ K
Sbjct: 1256 NLLKAQLNETL-TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)

Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
           +D+L+  +  +Q  L K  K        Q + K KL    KE  A   ++   L +E+  
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363

Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
            +KER   V++R++    +R   + +  ++  +   +     ++  M  Q++  ++  A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418

Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
                Q+NG +        +++   +  ++    ++ + L+ E      K  +L+QE   
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475

Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
            K   Q +      L  AE   E     ++ +    + A++    ++   E E+Q+L  +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533

Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
             L  +L  ++ L+ +    + + ++ +   E++    Q   +QNE L  Q+QQ  ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593

Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
                   A E  +V  EK +++++  D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)

Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
           ++++ A+ +  Q+ L+ K   +E E ++  ++ T  LV +    Q+             +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563

Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
           +E++  ++Q  +E+ +   A+ +  H +++ +   ++  EE    + E   +I   +  +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623

Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
           A +++     +   K        ++   +++ AL  E+ AA  + ++++Q ++       
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683

Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
            ++EQ Q   +N M      N+Q +ALK+                              K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743

Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
           L ++++  ET + Q    EEE+  +R   S   SL++E ++LK    DQ ++        
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800

Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
                    + + EE L+       N+E  V   +Q+ + L  ++     E+A       
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860

Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
             +E   +   K +++  +  VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)

Query: 84  NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
           +V E +  +   + +   QV  +SD  K     ++ + + +      +   +K+   Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169

Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
            K   + Q+K+              E      +R EA    L L  E + E+ +  K   
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212

Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
              +  EN+  +E  +     +  ++NAD+   + K   I       V+ I K+   K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272

Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
              ++ +A ++ +D  LS    +  E      +  +KE     Q+    ++   LT   +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332

Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           Q +     L ++++       + K+L +E+ T +      +S      +KD+    + T 
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383

Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
           E+     +N + ++ Q+ +++  + QQ    R  ME ++ H ++ + +  + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)

Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
           E D+  A  K  +  L +   +  E+  + + +LL            +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321

Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
           + + ++     ++       +A+ E+  A   +CK+L QE+   KE++      M+    
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381

Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
              +E  +       Q     + Q+ ++++ + Q +R       +  ++EN  L+D  + 
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435

Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
           T +  E       N +   +Q    L  +L +   +    E+Q ++A +A+     ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492

Query: 422 LER 424
            ER
Sbjct: 493 AER 495



 Score = 32.7 bits (73), Expect = 0.68
 Identities = 73/385 (18%), Positives = 156/385 (40%), Gaps = 63/385 (16%)

Query: 107  SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
            ++KEKT+  L +E+  L+         K  Q  +  + +E + L    E Q    +A + 
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 161  EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
            EK   L     + Q  +E +E++ + +Q +A     EA + ++  E+ + + E    +EN
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940

Query: 218  DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
            ++   E + +   +D          +Q    +   +I + K+   +  +     EE+  +
Sbjct: 941  ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000

Query: 267  IEERDAALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQA 321
            I ER+  +S    +   L+  + H  K+ N     N   + A  + E+ L+ K+    + 
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1060

Query: 322  RETAVQQYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EE 353
            R+  V+  + + +E ++ L    S+  +LS                            E 
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120

Query: 354  NLK--DQFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
             LK  D+ +  L      Y+  L   E I+   Q+  E+   + +  + E      Q+Q 
Sbjct: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1180

Query: 408  AREASQVANEKVQKLERLVDVLRKK 432
            +  +S+   E+++   + ++ LR++
Sbjct: 1181 SFTSSEQELERLRSENKDIENLRRE 1205


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)

Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
           ++   + K  Q+++ K++ EQ   + K++LQE     +E ++ I ++TA        ++ 
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
            + A++   +++ S+L   +  + +   R   M++     + +N EE+  M +Q++L + 
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578

Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
                 I    + IA Q + +++ + ++K    K +   +   +L  ERD   SK    E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634

Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
           +EL  ++  N      ++ L A  N++ A   +L  MQQ+      + + LEE++Q    
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690

Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
            + +   + + + L DQ N  L +  + L+       +++Q N+++  Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)

Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
           +D+L+  +  +Q  L K  K        Q + K KL    KE  A   ++   L +E+  
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363

Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
            +KER   V++R++    +R   + +  ++  +   +     ++  M  Q++  ++  A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418

Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
                Q+NG +        +++   +  ++    ++ + L+ E      K  +L+QE   
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475

Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
            K   Q +      L  AE   E     ++ +    + A++    ++   E E+Q+L  +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533

Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
             L  +L  ++ L+ +    + + ++ +   E++    Q   +QNE L  Q+QQ  ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593

Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
                   A E  +V  EK +++++  D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)

Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
           ++++ A+ +  Q+ L+ K   +E E ++  ++ T  LV +    Q+             +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563

Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
           +E++  ++Q  +E+ +   A+ +  H +++ +   ++  EE    + E   +I   +  +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623

Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
           A +++     +   K        ++   +++ AL  E+ AA  + ++++Q ++       
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683

Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
            ++EQ Q   +N M      N+Q +ALK+                              K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743

Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
           L ++++  ET + Q    EEE+  +R   S   SL++E ++LK    DQ ++        
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800

Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
                    + + EE L+       N+E  V   +Q+ + L  ++     E+A       
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860

Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
             +E   +   K +++  +  VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)

Query: 84  NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
           +V E +  +   + +   QV  +SD  K     ++ + + +      +   +K+   Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169

Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
            K   + Q+K+              E      +R EA    L L  E + E+ +  K   
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212

Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
              +  EN+  +E  +     +  ++NAD+   + K   I       V+ I K+   K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272

Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
              ++ +A ++ +D  LS    +  E      +  +KE     Q+    ++   LT   +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332

Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           Q +     L ++++       + K+L +E+ T +      +S      +KD+    + T 
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383

Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
           E+     +N + ++ Q+ +++  + QQ    R  ME ++ H ++ + +  + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)

Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
           E D+  A  K  +  L +   +  E+  + + +LL            +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321

Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
           + + ++     ++       +A+ E+  A   +CK+L QE+   KE++      M+    
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381

Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
              +E  +       Q     + Q+ ++++ + Q +R       +  ++EN  L+D  + 
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435

Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
           T +  E       N +   +Q    L  +L +   +    E+Q ++A +A+     ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492

Query: 422 LER 424
            ER
Sbjct: 493 AER 495



 Score = 32.7 bits (73), Expect = 0.68
 Identities = 71/365 (19%), Positives = 147/365 (40%), Gaps = 52/365 (14%)

Query: 107  SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
            ++KEKT+  L +E+  L+         K  Q  +  + +E + L    E Q    +A + 
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 161  EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
            EK   L     + Q  +E +E++ + +Q +A     EA + ++  E+ + + E    +EN
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940

Query: 218  DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
            ++   E + +   +D          +Q    +   +I + K+   +  +     EE+  +
Sbjct: 941  ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000

Query: 267  IEERDAALSKCKRLEQELHHVKE--QNQTSANNMRHLTAENNQERALKAKLLSMQQARET 324
            I ER+  +S    L  EL  +K+  ++Q   NN R    E  +  A +       +    
Sbjct: 1001 ISEREKEISG---LWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVP 1057

Query: 325  AVQQY--------KKLEE---------EIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYE 367
            +   Y        KK +E         E++ L      HK L + + +          Y+
Sbjct: 1058 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLE-----HK-LKEADEMHTLLQLECEKYK 1111

Query: 368  EALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVD 427
              L   E I+   Q+  E+   + +  + E      Q+Q +  +S+   E+++   + ++
Sbjct: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171

Query: 428  VLRKK 432
             LR++
Sbjct: 1172 NLRRE 1176


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)

Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
           ++   + K  Q+++ K++ EQ   + K++LQE     +E ++ I ++TA        ++ 
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520

Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
            + A++   +++ S+L   +  + +   R   M++     + +N EE+  M +Q++L + 
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578

Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
                 I    + IA Q + +++ + ++K    K +   +   +L  ERD   SK    E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634

Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
           +EL  ++  N      ++ L A  N++ A   +L  MQQ+      + + LEE++Q    
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690

Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
            + +   + + + L DQ N  L +  + L+       +++Q N+++  Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 87/405 (21%), Positives = 174/405 (42%), Gaps = 62/405 (15%)

Query: 28   EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
            E +    E  +  K T+L+ ++  EN  +  Q    +  N+Q  SS+P  E +    +E+
Sbjct: 946  EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004

Query: 83   YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
               +    N++    + +   +  ++  +EK      + ++ L ++ K LQ K+ K  KE
Sbjct: 1005 EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1060

Query: 141  QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
            +++    +EL+ KE   K+  K +      Y       E          ++  E +A   
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1110

Query: 201  HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
              E  +KVLE+   E ++M TL +L     +   A+T   +QK     + R  + +E K 
Sbjct: 1111 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1164

Query: 257  RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
            ++  +E    I++  ++ +     EQEL  ++ +N+   N  R       +   L+ +L 
Sbjct: 1165 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRR-------EREHLEMELE 1214

Query: 317  SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENI 376
              +  R T V + ++L++ +  L            ++ L D       +Y EA++  E +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTEL------------QKKLDD-------SYSEAVRQNEEL 1255

Query: 377  VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
              +  Q NE L T+L+    ER  +   L  A+++ ++   K+ K
Sbjct: 1256 NLLKAQLNETL-TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)

Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
           +D+L+  +  +Q  L K  K        Q + K KL    KE  A   ++   L +E+  
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363

Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
            +KER   V++R++    +R   + +  ++  +   +     ++  M  Q++  ++  A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418

Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
                Q+NG +        +++   +  ++    ++ + L+ E      K  +L+QE   
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475

Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
            K   Q +      L  AE   E     ++ +    + A++    ++   E E+Q+L  +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533

Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
             L  +L  ++ L+ +    + + ++ +   E++    Q   +QNE L  Q+QQ  ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593

Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
                   A E  +V  EK +++++  D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)

Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
           ++++ A+ +  Q+ L+ K   +E E ++  ++ T  LV +    Q+             +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563

Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
           +E++  ++Q  +E+ +   A+ +  H +++ +   ++  EE    + E   +I   +  +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623

Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
           A +++     +   K        ++   +++ AL  E+ AA  + ++++Q ++       
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683

Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
            ++EQ Q   +N M      N+Q +ALK+                              K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743

Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
           L ++++  ET + Q    EEE+  +R   S   SL++E ++LK    DQ ++        
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800

Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
                    + + EE L+       N+E  V   +Q+ + L  ++     E+A       
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860

Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
             +E   +   K +++  +  VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)

Query: 84  NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
           +V E +  +   + +   QV  +SD  K     ++ + + +      +   +K+   Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169

Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
            K   + Q+K+              E      +R EA    L L  E + E+ +  K   
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212

Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
              +  EN+  +E  +     +  ++NAD+   + K   I       V+ I K+   K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272

Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
              ++ +A ++ +D  LS    +  E      +  +KE     Q+    ++   LT   +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332

Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
           Q +     L ++++       + K+L +E+ T +      +S      +KD+    + T 
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383

Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
           E+     +N + ++ Q+ +++  + QQ    R  ME ++ H ++ + +  + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)

Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
           E D+  A  K  +  L +   +  E+  + + +LL            +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321

Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
           + + ++     ++       +A+ E+  A   +CK+L QE+   KE++      M+    
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381

Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
              +E  +       Q     + Q+ ++++ + Q +R       +  ++EN  L+D  + 
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435

Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
           T +  E       N +   +Q    L  +L +   +    E+Q ++A +A+     ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492

Query: 422 LER 424
            ER
Sbjct: 493 AER 495



 Score = 32.7 bits (73), Expect = 0.68
 Identities = 73/385 (18%), Positives = 156/385 (40%), Gaps = 63/385 (16%)

Query: 107  SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
            ++KEKT+  L +E+  L+         K  Q  +  + +E + L    E Q    +A + 
Sbjct: 825  ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884

Query: 161  EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
            EK   L     + Q  +E +E++ + +Q +A     EA + ++  E+ + + E    +EN
Sbjct: 885  EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940

Query: 218  DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
            ++   E + +   +D          +Q    +   +I + K+   +  +     EE+  +
Sbjct: 941  ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000

Query: 267  IEERDAALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQA 321
            I ER+  +S    +   L+  + H  K+ N     N   + A  + E+ L+ K+    + 
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1060

Query: 322  RETAVQQYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EE 353
            R+  V+  + + +E ++ L    S+  +LS                            E 
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120

Query: 354  NLK--DQFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
             LK  D+ +  L      Y+  L   E I+   Q+  E+   + +  + E      Q+Q 
Sbjct: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1180

Query: 408  AREASQVANEKVQKLERLVDVLRKK 432
            +  +S+   E+++   + ++ LR++
Sbjct: 1181 SFTSSEQELERLRSENKDIENLRRE 1205


>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
          Length = 284

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 71/284 (25%), Positives = 124/284 (43%), Gaps = 42/284 (14%)

Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
           EL  L+   K  + +L K  +  +  + KLEL EK+     A+  A+L   +   ++E D
Sbjct: 42  ELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEAD-VASLNRRIQLVEEELD 100

Query: 179 EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAI 237
            A   RL  A+++ +EA   A   E  +KV+E+    +E  M +QE+  ++  A      
Sbjct: 101 RA-QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEI--QLKEA------ 151

Query: 238 QKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANN 297
            K+ A   DR Y+    K+ I   ++    E  + +  KC  LE+EL       +T  NN
Sbjct: 152 -KHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEEL-------KTVTNN 203

Query: 298 MRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKD 357
           ++ L A+                  E   Q+  + EEEI+       L   L + E   +
Sbjct: 204 LKSLEAQ-----------------AEKYSQKEDRYEEEIKV------LSDKLKEAETRAE 240

Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANM 401
               +++  E+++ + E  V+  +++N  +   L Q L E  NM
Sbjct: 241 FAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 31/130 (23%), Positives = 59/130 (45%), Gaps = 18/130 (13%)

Query: 298 MRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKD 357
           M  L  EN  +RA +A     +  ++ A  + K+LE+E+       SL K L   E+  D
Sbjct: 10  MLKLDKENALDRAEQA-----EADKKAAEDRSKQLEDEL------VSLQKKLKGTEDELD 58

Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
           +       Y EALK+ +  + + +++  +    +         +E +L  A+E    A +
Sbjct: 59  K-------YSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQ 111

Query: 418 KVQKLERLVD 427
           K+++ E+  D
Sbjct: 112 KLEEAEKAAD 121



 Score = 29.3 bits (64), Expect = 7.5
 Identities = 35/165 (21%), Positives = 75/165 (45%), Gaps = 22/165 (13%)

Query: 269 ERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQ 328
           ++ AA  + K+LE EL  ++++ + + + +      +    ALK      Q+  E A ++
Sbjct: 28  DKKAAEDRSKQLEDELVSLQKKLKGTEDEL------DKYSEALK----DAQEKLELAEKK 77

Query: 329 YKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA 388
               E ++       SL++ +   E   D+    L+T  + L+  E     +++  + + 
Sbjct: 78  ATDAEADVA------SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 131

Query: 389 TQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
           ++ Q+   +   ME+Q    +EA  +A +  +K E   +V RK V
Sbjct: 132 SRAQK---DEEKMEIQEIQLKEAKHIAEDADRKYE---EVARKLV 170


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 65/328 (19%), Positives = 138/328 (42%), Gaps = 56/328 (17%)

Query: 107  SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
            S KE+ +++L  +L     +  K+Q ++ +++   + L  +LE+Q KE + +I +    L
Sbjct: 1402 SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVEL 1461

Query: 167  VE-----EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTL 221
             E     E    +    + +  +LQ A+  R EA+   K ++  L +           T+
Sbjct: 1462 CEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG--------TI 1513

Query: 222  QELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
            + L   + + ++ ++ Q       ++   T   ++ +  EE   LI E D +L       
Sbjct: 1514 ERLTKSLADVESQVSAQ-------NKEKDTVLGRLALLQEERDKLITEMDRSLL------ 1560

Query: 282  QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
                                     + ++L +   S++ A E   +  +KL +EI++L+ 
Sbjct: 1561 -------------------------ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595

Query: 342  YYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRE---NIVSITQQQNEELATQLQQALT 396
                  +  QE++  L+ ++   L +YE      E   ++V   +Q+ +EL  +L+    
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655

Query: 397  ERANMELQLQHAREASQVANEKVQKLER 424
             +   E QLQ A +  +   EK++K  +
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAK 1683



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 78/377 (20%), Positives = 167/377 (44%), Gaps = 70/377 (18%)

Query: 108  DKEKTIAFLLKELDILRTSNKK--------LQQKLAKEDKEQRKL-KFKLELQEKETEA- 157
            +K   +   +K L+ ++T ++K        L Q +    K Q +L  FK+ L + ++EA 
Sbjct: 2033 EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092

Query: 158  -------KIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVL- 209
                   K+ ++  +  E V    K++DE +  RL+ A E+    +   K+M+  L  L 
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH---LKEKKNMQEKLDALR 2149

Query: 210  -ENINPEENDMTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSALI 267
             E ++ EE   T+ E+   +N  D  +  +Q+N          +   ++    + MS+L 
Sbjct: 2150 REKVHLEE---TIGEIQVTLNKKDKEVQQLQEN--------LDSTVTQLAAFTKSMSSLQ 2198

Query: 268  EERDAALSKCKRLEQELH----------HVKEQN-QTSANNMRHLTAENNQERALKAKLL 316
            ++RD  + + K+ E++             +KE N     + +R ++    + +   ++L 
Sbjct: 2199 DDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE 2258

Query: 317  SMQQARETAVQQYKKLEEEI----------------QTLRVYYSLHKSLSQEEN----LK 356
              +Q  E+  Q   +L++++                +T  +Y+S    L++ E+    LK
Sbjct: 2259 HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLK 2318

Query: 357  DQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVAN 416
            DQ     ++ E+  + + N+  I +QQ  +    +Q +      +E  LQ +RE +   +
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQEAD----IQNSKFSYEQLETDLQASRELTSRLH 2374

Query: 417  EKV-QKLERLVDVLRKK 432
            E++  K ++++ +L  K
Sbjct: 2375 EEINMKEQKIISLLSGK 2391



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/332 (19%), Positives = 140/332 (42%), Gaps = 60/332 (18%)

Query: 131 QQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
           +++L+K DK       E  K+K KL+ +E+      A+ T A  E+   +  E +E VM 
Sbjct: 129 EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM 188

Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ--------ELLNRINNADTGI 235
           + QL  +E   +  +A+  +   +        E D   +        ELL  +  AD   
Sbjct: 189 KQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET 248

Query: 236 AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSA 295
            +Q+               K+R+   ++    E           L+QEL   +++NQ  +
Sbjct: 249 EMQQ---------------KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293

Query: 296 NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENL 355
             ++ + AE+N  R       +++  RE +    +K+E E+   ++ +          NL
Sbjct: 294 QQLQQMEAEHNTLRN------TVETEREESKILLEKMELEVAERKLSF---------HNL 338

Query: 356 KDQFNYTLSTYEEALKNRENIVS----ITQQQNEELATQLQQALT-ERANMELQ------ 404
           +++ ++ L  +E+A + +  + S    + Q+   E+  +    L+ ++   ELQ      
Sbjct: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398

Query: 405 ----LQHAREASQVANEKVQKLERLVDVLRKK 432
                +  ++ ++ A +  Q +++L D L++K
Sbjct: 399 KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 38/341 (11%)

Query: 102  QVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE 161
            QVT+   +E T+     +L +      +L    +   K   +L+ +L   +KE   K+ E
Sbjct: 2617 QVTA-LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTL 221
                L +E+       D  +M       EER   +AR   +EM  K+L  +  E   +T 
Sbjct: 2676 IEDKLKKEL--KHLHHDAGIMRNETETAEERVAELARDL-VEMEQKLLM-VTKENKGLTA 2731

Query: 222  QELLNRINNADTGIAIQKNGAII-VDRIYKTKECKMRITAE--EMSALIEERDAALSKCK 278
            Q  +     + + +   ++ A   +D + +  +  ++  A+  E   L  ERDA LS+  
Sbjct: 2732 Q--IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSET- 2788

Query: 279  RLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETA---VQQYKKLEEE 335
                        N T  N++ HL   N Q  +   +LL +    E +   VQ + K    
Sbjct: 2789 --------AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840

Query: 336  IQTLR--VYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA----- 388
            +Q  R  ++  L K    EE  K +     ST    +++ +  +S  Q   + L      
Sbjct: 2841 LQNERDHLWNELEKFRKSEEG-KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899

Query: 389  -----TQLQQALTERANMELQLQHARE---ASQVANEKVQK 421
                  Q+ Q +TE   ++ QLQ  ++   A Q+  E++++
Sbjct: 2900 LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 67/332 (20%), Positives = 140/332 (42%), Gaps = 61/332 (18%)

Query: 119  ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKET----------EAKIAEKTAALVE 168
            ++++L+     +Q + +++    R L+ +L+ +E E            +K+ E + AL +
Sbjct: 811  KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870

Query: 169  --------EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDM- 219
                    +    +K+RD   +  LQ  IEE+D+ +       M+ K+++ +N E+  + 
Sbjct: 871  KELEITKMDQLLLEKKRD---VETLQQTIEEKDQQVTEIS-FSMTEKMVQ-LNEEKFSLG 925

Query: 220  ----TLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKM----RITAEEMS------- 264
                TL+E LN ++ A+     Q      V    K    +M    +I+ EE+        
Sbjct: 926  VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985

Query: 265  -----------ALIEERDAALSKCKRLEQELHHVKEQNQTS---ANNMRHLTAEN--NQE 308
                       A +  R   L +  RLE+EL ++K++++     +   R    E+  N+E
Sbjct: 986  KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE 1045

Query: 309  RALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEE 368
             + K      Q+      Q   + E E+Q +R      K L ++   ++QF   +    +
Sbjct: 1046 YSEKCVTSKCQEIEIYLKQTISEKEVELQHIR------KDLEEKLAAEEQFQALVKQMNQ 1099

Query: 369  ALKNRENIVSITQQQNEELATQLQQALTERAN 400
             L+++ N + + Q +  E    +Q+ +T   +
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 68/360 (18%), Positives = 142/360 (39%), Gaps = 42/360 (11%)

Query: 92  DMHYECMTPCQVTSDSDKEKTIAF---LLKEL-DILRTSNKKLQQKLAKEDKEQRKLKFK 147
           ++H E       T+  D ++ +A+   L+ EL DI+R  + +LQQK     +E++    K
Sbjct: 33  ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK 92

Query: 148 LELQEKETEAKIAEKTAALVE-----EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHM 202
           ++  +   +AK+      + E           + + E  +S+   +  E +  I + KH 
Sbjct: 93  IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK 152

Query: 203 EMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEE 262
               + L +    +      E   + +       + K      +    T + ++  T  E
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212

Query: 263 MSA--LIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQ 320
            +A  ++ E+DA      RL ++              +  L  + + E  ++ KL  +Q 
Sbjct: 213 QAAQQVVREKDARFETQVRLHED-------------ELLQLVTQADVETEMQQKLRVLQ- 258

Query: 321 ARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALK----NRENI 376
                    +KLEE  ++L     +   L QE    +Q N  LS   + ++       N 
Sbjct: 259 ---------RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309

Query: 377 VSITQQQNEELATQLQQALTERA----NMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
           V   +++++ L  +++  + ER     N++ ++ H  E  + A +   +LE     L +K
Sbjct: 310 VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK 369



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 72/340 (21%), Positives = 150/340 (44%), Gaps = 57/340 (16%)

Query: 107  SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
            S K+  +  L +E+  +   N+++Q++L++  K    LK   E ++ + E ++  + A L
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTK----LKETAEEEKDDLEERLMNQLAEL 1933

Query: 167  -------VEEVYFAQKERD--EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN 217
                    ++V  AQ + +  E+ M  L+  + E +E   + + ++   KV   I     
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE--KQQLVKEKTKVESEIR---- 1987

Query: 218  DMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC 277
                +E L +I  A                    KE   +  A+E+  L++E+     + 
Sbjct: 1988 ----KEYLEKIQGAQ-------------------KEPGNKSHAKELQELLKEKQ---QEV 2021

Query: 278  KRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQ 337
            K+L+++   ++ Q + SA        E  Q  + K   ++ +   + AV+  KK + E+ 
Sbjct: 2022 KQLQKDC--IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ-AVEHRKKAQAELA 2078

Query: 338  TLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQA--- 394
            + +V     +S +    L D     L   +E   N+E++ S  +Q++E+L  +L+QA   
Sbjct: 2079 SFKVLLDDTQSEAARV-LADN----LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133

Query: 395  -LTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
             L E+ NM+ +L   R       E + +++  ++   K+V
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 68/343 (19%), Positives = 143/343 (41%), Gaps = 40/343 (11%)

Query: 110 EKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE 169
           E T +   KEL +L    K+ Q+++A           KL+LQ K  E    E    ++++
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAF---------LKLQLQGKRAE----EADHEVLDQ 595

Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN--INPEENDMTLQELLNR 227
               Q E +     ++++ +E+  +      + E SL  +E    + E    T +E+   
Sbjct: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI--S 653

Query: 228 INNADTGI-AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC-----KRLE 281
           +N+A   + + +++G   +  +    +C      E + + I E +    K      K L+
Sbjct: 654 LNDAGVELKSTKQDGDKSLSAVPDIGQCHQD-ELERLKSQILELELNFHKAQEIYEKNLD 712

Query: 282 QELHHVKEQNQ-------TSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEE 334
           ++   +   NQ        + NN    TA + +   L +++  +    E   Q  K+LE 
Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQ-VKQLEM 771

Query: 335 EIQTLRVYYSL-HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQ 393
            +        L ++S +  +NL  +  ++LS      K+++  + + Q + +++  Q  +
Sbjct: 772 NLAEAERQRRLDYESQTAHDNLLTEQIHSLSI---EAKSKDVKIEVLQNELDDVQLQFSE 828

Query: 394 ALTERANMELQLQHAREASQVANEKVQ----KLERLVDVLRKK 432
             T   +++ QLQ+         E+V+    K+E L   L +K
Sbjct: 829 QSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK 871



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 79/454 (17%), Positives = 179/454 (39%), Gaps = 62/454 (13%)

Query: 28   EQLTMNSEKSMHRKSTELVNEITCENTEWPGQRST---NFQIISSYPDDESVYCTTEKYN 84
            E LT + EK + ++   L +    E+TEW  +       ++I+    ++ S      ++ 
Sbjct: 1577 EGLTEDKEKLV-KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHV 1635

Query: 85   VMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKL----QQKLAKEDKE 140
            V   R               +  + EK +    +E++ ++   +K     QQK+ + ++E
Sbjct: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695

Query: 141  QRKLKFKLELQ---EKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIA 197
              +L+ ++       KE    +    A++ EE+   + E  E +  + Q  + E+D    
Sbjct: 1696 NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY-ETLSKKFQSLMSEKDSLSE 1754

Query: 198  RAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIA-----IQKNGAIIV------- 245
              + ++  ++   N++ + N    ++  N+ N  + G        ++  ++ +       
Sbjct: 1755 EVQDLKHQIE--GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS 1812

Query: 246  DRIYKTKECKMRITAE-----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
            + +   K     ++ +     E++  +++ D    +   LE+E    KE +QT  N    
Sbjct: 1813 ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNT 1872

Query: 301  LTAENN---------QERALKAKLLSMQ---------QARETAVQQYKKLEEEIQTLRVY 342
            L ++ +         QE   K  LL+ Q         + +ETA ++   LEE +  +   
Sbjct: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL--MNQL 1930

Query: 343  YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANME 402
              L+ S+                 E  +KN +  VS  +++ ++L  +  +  +E     
Sbjct: 1931 AELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY 1990

Query: 403  LQ-----------LQHAREASQVANEKVQKLERL 425
            L+             HA+E  ++  EK Q++++L
Sbjct: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 85/407 (20%), Positives = 162/407 (39%), Gaps = 90/407 (22%)

Query: 80   TEKYNVMEHRHNDMHYE-CMTP-CQVT------SDSDKEKTIAFLLKELD---------- 121
            TE+  V E + N  + E C+T  CQ        + S+KE  +  + K+L+          
Sbjct: 1032 TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091

Query: 122  -ILRTSNKKLQQKLAKEDKEQRKLKFKLELQEK----ETEAKIAEKTAAL---------- 166
             +++  N+ LQ K  + D  Q ++     + +K     T+A   +  A +          
Sbjct: 1092 ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPC 1151

Query: 167  ----------VEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEE 216
                      +EE   A ++  E +  +LQ A+  R   + +A+  E  L+  E +  ++
Sbjct: 1152 TGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR--EELKQQK 1209

Query: 217  NDMT-LQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
            +D   LQE  +  +  +  I  Q     I  ++ ++ + K+  T ++ S          S
Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQI--QVRESIDGKLPSTDQQESC---------S 1258

Query: 276  KCKRLEQELHHVKEQNQT----SANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKK 331
                LE+ L    EQ+ T     +N      + +    AL+           T+V Q K 
Sbjct: 1259 STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG---------GTSVAQIKA 1309

Query: 332  LEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEE-LATQ 390
              +EI+  +V   L  S               ST  E  K  E +  + +Q N++ L  +
Sbjct: 1310 QLKEIEAEKVELELKVS---------------STTSELTKKSEEVFQLQEQINKQGLEIE 1354

Query: 391  LQQALTERANMELQ-LQHAREASQV---ANEKVQKLERLVDVLRKKV 433
              + ++  A +  + LQ   E+SQ+     E +++L+  +D L+K +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI 1401


>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
          Length = 285

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 65/226 (28%), Positives = 102/226 (45%), Gaps = 16/226 (7%)

Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
           EL  ++   K  + +L K  +  +  + KLEL EK+     AE  A+L   +   ++E D
Sbjct: 43  ELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAE-VASLNRRIQLVEEELD 101

Query: 179 EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAI 237
            A   RL  A+++ +EA   A   E  +KV+EN    +E  M LQE+  ++  A      
Sbjct: 102 RA-QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI--QLKEA------ 152

Query: 238 QKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQTSAN 296
            K+ A   DR Y+    K+ I   ++    E  + A SKC  LE+EL +V        A 
Sbjct: 153 -KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQ 211

Query: 297 NMRHLTAENNQERALKA---KLLSMQQARETAVQQYKKLEEEIQTL 339
             ++   E+  E  +K    KL   +   E A +   KLE+ I  L
Sbjct: 212 AEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 257



 Score = 35.8 bits (81), Expect = 0.080
 Identities = 40/182 (21%), Positives = 75/182 (41%), Gaps = 16/182 (8%)

Query: 256 MRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM----RHLTAENNQERAL 311
           M    ++M  L  +++ AL + ++ E E    +E+++   + +    + L    ++    
Sbjct: 2   MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKY 61

Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALK 371
              L   Q+  E A ++    E E+       SL++ +   E   D+    L+T   AL+
Sbjct: 62  SEALKDAQEKLELAEKKAADAEAEVA------SLNRRIQLVEEELDRAQERLAT---ALQ 112

Query: 372 NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
             E       +    +     +AL +   MELQ    +EA  +A E  +K E   +V RK
Sbjct: 113 KLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE---EVARK 169

Query: 432 KV 433
            V
Sbjct: 170 LV 171



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 11/93 (11%)

Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLE-LQEKETEAKIAEKTAA 165
           S+ E+ +  +   L  L    +K  QK   EDK + ++K   + L+E ET A+ AE++ A
Sbjct: 192 SELEEELKNVTNNLKSLEAQAEKYSQK---EDKYEEEIKILTDKLKEAETRAEFAERSVA 248

Query: 166 LVEEVY-------FAQKERDEAVMSRLQLAIEE 191
            +E+         +AQK + +A+   L  A+ +
Sbjct: 249 KLEKTIDDLEDELYAQKLKYKAISEELDHALND 281


>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
          Length = 248

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 70/282 (24%), Positives = 123/282 (43%), Gaps = 42/282 (14%)

Query: 117 LKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKE 176
           L  L+ ++   + LQQ+  + +   + L+ +L+  E+E   K     AAL   +   ++E
Sbjct: 4   LNSLEAVKRKIQALQQQADEAEDRAQGLQRELD-GERERREKAEGDVAALNRRIQLVEEE 62

Query: 177 RDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGI 235
            D A   RL  A+++ +EA   A   E  +KV+EN    +E  M +QE+  ++  A    
Sbjct: 63  LDRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEM--QLKEA---- 115

Query: 236 AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSA 295
              K+ A   DR Y+    K+ I   E+    E  + +  KC  LE+EL +V        
Sbjct: 116 ---KHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNV-------T 165

Query: 296 NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENL 355
           NN++                 S++ A E   ++  K EEEI+       L   L + E  
Sbjct: 166 NNLK-----------------SLEAASEKYSEKEDKYEEEIKL------LSDKLKEAETR 202

Query: 356 KDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
            +    T++  E+ + + E  ++  +++N  L   L Q L E
Sbjct: 203 AEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNE 244



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 32/136 (23%), Positives = 58/136 (42%), Gaps = 14/136 (10%)

Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV--------YYSLHKSLSQEENLKD 357
           N   A+K K+ ++QQ  + A  + + L+ E+   R           +L++ +   E   D
Sbjct: 5   NSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELD 64

Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
           +    L+T   AL+  E       +    +     +A+ +   ME+Q    +EA  +A E
Sbjct: 65  RAQERLAT---ALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEE 121

Query: 418 KVQKLERLVDVLRKKV 433
             +K E   +V RK V
Sbjct: 122 ADRKYE---EVARKLV 134


>gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
          Length = 247

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 65/244 (26%), Positives = 111/244 (45%), Gaps = 18/244 (7%)

Query: 120 LDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDE 179
           ++ ++   + LQQ+    ++   +L+ ++E + +  E   AE  A+L   +   ++E D 
Sbjct: 7   IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDR 65

Query: 180 AVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAIQ 238
           A   RL  A+++ +EA   A   E  +KV+EN    +E  M LQE+  ++  A       
Sbjct: 66  A-QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI--QLKEA------- 115

Query: 239 KNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQTSANN 297
           K+ A   DR Y+    K+ I   ++    E  + A SKC  LE+EL +V        A  
Sbjct: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA 175

Query: 298 MRHLTAENNQERALKA---KLLSMQQARETAVQQYKKLEEEIQTL--RVYYSLHKSLSQE 352
            ++   E+  E  +K    KL   +   E A +   KLE+ I  L  R+Y  L ++    
Sbjct: 176 EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235

Query: 353 ENLK 356
             LK
Sbjct: 236 NELK 239



 Score = 36.6 bits (83), Expect = 0.047
 Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 14/132 (10%)

Query: 310 ALKAKLLSMQQARETAVQQYKKLEEEIQTLR--------VYYSLHKSLSQEENLKDQFNY 361
           A+K K+  +QQ  + A ++ ++L+ E++  R           SL++ +   E   D+   
Sbjct: 9   AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68

Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
            L+T   AL+  E       +    +     +AL +   MELQ    +EA  +A E  +K
Sbjct: 69  RLAT---ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125

Query: 422 LERLVDVLRKKV 433
            E   +V RK V
Sbjct: 126 YE---EVARKLV 134



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 26/93 (27%), Positives = 48/93 (51%), Gaps = 11/93 (11%)

Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLE-LQEKETEAKIAEKTAA 165
           S+ E+ +  +   L  L    +K  QK   EDK + ++K   + L+E ET A+ AE++ A
Sbjct: 155 SELEEELKNVTNNLKSLEAQAEKYSQK---EDKYEEEIKILTDKLKEAETRAEFAERSVA 211

Query: 166 LVE-------EVYFAQKERDEAVMSRLQLAIEE 191
            +E       E  ++Q ER+  + + L+L + +
Sbjct: 212 KLEKTIDDLEERLYSQLERNRLLSNELKLTLHD 244


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 97/470 (20%), Positives = 199/470 (42%), Gaps = 56/470 (11%)

Query: 1   MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELV-NEITCENTEWPGQ 59
           MEN S  +T +  E  TT  +      + L M  E     K  E++ NEI  E       
Sbjct: 467 MENQS--LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524

Query: 60  RSTNFQIISSYPDDESVYCT----TEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAF 115
           ++ +  ++      E    T    +E+   +  + N+   + ++  +  S    E  +  
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584

Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
           + KE  IL  S K+   KL+K + E+R++K +LE  +++      E+   L  E++  +K
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK-----GERAEELENELHHLEK 639

Query: 176 ERD--EAVMSRLQL------AIEERDEAIARA-----------KHMEMSLKVLENINPE- 215
           E +  +  ++ L++      A+E+ +  + R            K++   L+ LE  N + 
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699

Query: 216 -ENDMTLQELLNRINNADTGIA-IQ-------------KNGAIIVDRIYKTKECKMRITA 260
            E ++ L+  +  +  A   +A +Q             K G  ++   +K  E ++ ++ 
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSY 758

Query: 261 E----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
           +    E   L +  + +  K ++LE EL  ++ +NQT   N+  L   + +   L+ +  
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818

Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK----DQFNYTLSTYEEALKN 372
           S++Q      +  K+LE+E + LR    +  +  +E N+K    ++ N TLS      K 
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 373 RENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKL 422
               +   +++N+EL  +    +     +   L   +  +Q  N  ++KL
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 71/349 (20%), Positives = 158/349 (45%), Gaps = 45/349 (12%)

Query: 119 ELDILRTSN---KKLQQKLAKEDKEQRKLKF-KLELQEKETEAKIAEKTAALVEEVYFAQ 174
           ELD LR       KL+ ++++  +    ++F K  ++E + + ++  +T  ++E+     
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370

Query: 175 KERDEAV----MSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ-------- 222
           + R + +       LQL  +  D  + R    +M  K +E +   E +MTL+        
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER----DMDRKKIEELM--EENMTLEMAQKQSMD 424

Query: 223 -------ELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
                  EL      ++   A QK+    V+ +  ++  K+ +  + ++  +EE    + 
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484

Query: 276 KCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEE 335
             +    ++  ++++NQ  +  +  L  E  QE   K  L + Q   +  +++  +LE+ 
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQE---KQSLQNCQNLSKDLMKEKAQLEKT 541

Query: 336 IQTLRVYYSLHKSLSQEENLKDQFNYTLSTY--------EEALKNRENIVSITQQQNEEL 387
           I+TLR        + ++EN  +  N T+S+         E  +K+ E    I  +  +E 
Sbjct: 542 IETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599

Query: 388 ATQLQQALTERANMELQLQHAREASQVANE---KVQKLERLVDVLRKKV 433
           +++L +   E+  ++ +L+H +E  + A E   ++  LE+  ++L+KK+
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 87/473 (18%), Positives = 184/473 (38%), Gaps = 64/473 (13%)

Query: 1    MENWSKDITHSYLEQETTGINKSTQ-PDEQLTMNSE--------KSMHRKSTELVNEITC 51
            M N  + +TH   E E  G+NK     DEQ T +S         +S  +KS E+  E   
Sbjct: 921  MNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA 977

Query: 52   ENTEWPGQRSTNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEK 111
               E   + STN+    +    + +    + Y  ++ R ++      +P     D+  E+
Sbjct: 978  A-LEARLEESTNY----NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032

Query: 112  TIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVY 171
                  +EL  L+  ++ ++ +      +  K   K +L++ ET+    +     ++   
Sbjct: 1033 ESQETTREL--LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090

Query: 172  FAQKERDEAVMS---RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRI 228
             + +E++  + +   +LQ+     +       +    L + ++    EN+  ++E  +  
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150

Query: 229  NNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVK 288
            +  D+ I   +   ++ +R            A E  +LI +     S  K LE E   ++
Sbjct: 1151 SLYDSLIKDHEKLELLHER-----------QASEYESLISKHGTLKSAHKNLEVEHRDLE 1199

Query: 289  EQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS---- 344
            ++          L       +  + K+L   +  ET   +YKKL  E   L   YS    
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259

Query: 345  ---------------LHKSLSQEENLKDQFNYTLSTYEE------ALKNRENIVS----I 379
                           L+ S  ++  L+ +F+     Y++       L N+  ++S     
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
             +++N  L  Q+Q  + +   +  Q   +++   V  E+ Q +++L ++ R+K
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1370



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 42/278 (15%)

Query: 190 EERDEAIARAKHMEMSLK------VLENINPEENDMTLQELLNRINNADTGIAIQKNGAI 243
           ++++E I R + ++   K      + E  + +EN   LQ +     + +    + KN A+
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195

Query: 244 IVDRIYKTKECKMRITAEEMSALIEERD----------AALSKC-----KRLEQELHHVK 288
            + R+   ++      +E +  L EERD          +A S C     KR E   H   
Sbjct: 196 HLKRLIDERDEH----SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV 251

Query: 289 EQNQTSANNMR---HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSL 345
           E     A   R    L  +  Q    K +L  M+   +   Q+   L  + ++ R+Y   
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311

Query: 346 HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
             +L ++    D+    +S Y+E L +    +   + + EEL    Q  L  +  +E QL
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQL 367

Query: 406 QHAREASQVANE----------KVQKLERLVDVLRKKV 433
           +  R  S   +E          K+  +E   D+ RKK+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 97/470 (20%), Positives = 199/470 (42%), Gaps = 56/470 (11%)

Query: 1   MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELV-NEITCENTEWPGQ 59
           MEN S  +T +  E  TT  +      + L M  E     K  E++ NEI  E       
Sbjct: 467 MENQS--LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524

Query: 60  RSTNFQIISSYPDDESVYCT----TEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAF 115
           ++ +  ++      E    T    +E+   +  + N+   + ++  +  S    E  +  
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584

Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
           + KE  IL  S K+   KL+K + E+R++K +LE  +++      E+   L  E++  +K
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK-----GERAEELENELHHLEK 639

Query: 176 ERD--EAVMSRLQL------AIEERDEAIARA-----------KHMEMSLKVLENINPE- 215
           E +  +  ++ L++      A+E+ +  + R            K++   L+ LE  N + 
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699

Query: 216 -ENDMTLQELLNRINNADTGIA-IQ-------------KNGAIIVDRIYKTKECKMRITA 260
            E ++ L+  +  +  A   +A +Q             K G  ++   +K  E ++ ++ 
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSY 758

Query: 261 E----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
           +    E   L +  + +  K ++LE EL  ++ +NQT   N+  L   + +   L+ +  
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818

Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK----DQFNYTLSTYEEALKN 372
           S++Q      +  K+LE+E + LR    +  +  +E N+K    ++ N TLS      K 
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878

Query: 373 RENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKL 422
               +   +++N+EL  +    +     +   L   +  +Q  N  ++KL
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 71/349 (20%), Positives = 158/349 (45%), Gaps = 45/349 (12%)

Query: 119 ELDILRTSN---KKLQQKLAKEDKEQRKLKF-KLELQEKETEAKIAEKTAALVEEVYFAQ 174
           ELD LR       KL+ ++++  +    ++F K  ++E + + ++  +T  ++E+     
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370

Query: 175 KERDEAV----MSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ-------- 222
           + R + +       LQL  +  D  + R    +M  K +E +   E +MTL+        
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER----DMDRKKIEELM--EENMTLEMAQKQSMD 424

Query: 223 -------ELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
                  EL      ++   A QK+    V+ +  ++  K+ +  + ++  +EE    + 
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484

Query: 276 KCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEE 335
             +    ++  ++++NQ  +  +  L  E  QE   K  L + Q   +  +++  +LE+ 
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQE---KQSLQNCQNLSKDLMKEKAQLEKT 541

Query: 336 IQTLRVYYSLHKSLSQEENLKDQFNYTLSTY--------EEALKNRENIVSITQQQNEEL 387
           I+TLR        + ++EN  +  N T+S+         E  +K+ E    I  +  +E 
Sbjct: 542 IETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599

Query: 388 ATQLQQALTERANMELQLQHAREASQVANE---KVQKLERLVDVLRKKV 433
           +++L +   E+  ++ +L+H +E  + A E   ++  LE+  ++L+KK+
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 85/472 (18%), Positives = 183/472 (38%), Gaps = 63/472 (13%)

Query: 1    MENWSKDITHSYLEQETTGINK--------STQPDEQLTMNSEKSMHRKSTELVNEITCE 52
            M N  + +TH   E E  G+NK        ST    +L  +  +S  +KS E+  E    
Sbjct: 921  MNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977

Query: 53   NTEWPGQRSTNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKT 112
              E   + STN+    +    + +    + Y  ++ R ++      +P     D+  E+ 
Sbjct: 978  -LEARLEESTNY----NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
                 +EL  L+  ++ ++ +      +  K   K +L++ ET+    +     ++    
Sbjct: 1033 SQETTREL--LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090

Query: 173  AQKERDEAVMS---RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRIN 229
            + +E++  + +   +LQ+     +       +    L + ++    EN+  ++E  +  +
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150

Query: 230  NADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKE 289
              D+ I   +   ++ +R            A E  +LI +     S  K LE E   +++
Sbjct: 1151 LYDSLIKDHEKLELLHER-----------QASEYESLISKHGTLKSAHKNLEVEHRDLED 1199

Query: 290  QNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS----- 344
            +          L       +  + K+L   +  ET   +YKKL  E   L   YS     
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259

Query: 345  --------------LHKSLSQEENLKDQFNYTLSTYEE------ALKNRENIVS----IT 380
                          L+ S  ++  L+ +F+     Y++       L N+  ++S      
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1319

Query: 381  QQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
            +++N  L  Q+Q  + +   +  Q   +++   V  E+ Q +++L ++ R+K
Sbjct: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1369



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 42/278 (15%)

Query: 190 EERDEAIARAKHMEMSLK------VLENINPEENDMTLQELLNRINNADTGIAIQKNGAI 243
           ++++E I R + ++   K      + E  + +EN   LQ +     + +    + KN A+
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195

Query: 244 IVDRIYKTKECKMRITAEEMSALIEERD----------AALSKC-----KRLEQELHHVK 288
            + R+   ++      +E +  L EERD          +A S C     KR E   H   
Sbjct: 196 HLKRLIDERDEH----SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV 251

Query: 289 EQNQTSANNMR---HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSL 345
           E     A   R    L  +  Q    K +L  M+   +   Q+   L  + ++ R+Y   
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311

Query: 346 HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
             +L ++    D+    +S Y+E L +    +   + + EEL    Q  L  +  +E QL
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQL 367

Query: 406 QHAREASQVANE----------KVQKLERLVDVLRKKV 433
           +  R  S   +E          K+  +E   D+ RKK+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405


>gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]
          Length = 284

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 18/252 (7%)

Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
           L +E   L+   K  + ++ K  +  ++ + KLE  EK+     A+  A+L   +   ++
Sbjct: 39  LEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEAD-VASLNRRIQLVEE 97

Query: 176 ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTG 234
           E D A   RL  A+++ +EA   A   E  +KV+EN    +E  M LQE+  ++  A   
Sbjct: 98  ELDRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEM--QLKEA--- 151

Query: 235 IAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQT 293
               K+ A   DR Y+    K+ I   E+    E  + A SKC  LE+EL  V       
Sbjct: 152 ----KHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSL 207

Query: 294 SANNMRHLTAENNQE---RALKAKLLSMQQARETAVQQYKKLEEEIQTL--RVYYSLHKS 348
            A   ++ T E+  E   + L+ KL   +   E A +   KLE+ I  L   VY    K 
Sbjct: 208 EAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKY 267

Query: 349 LSQEENLKDQFN 360
            +  E L +  N
Sbjct: 268 KAISEELDNALN 279



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 12/88 (13%)

Query: 116 LLKELDILRTSNKKLQQKL----AKEDKEQRKLKFKLE-LQEKETEAKIAEKTAALVEEV 170
           L +EL I+  + K L+ +      KEDK + ++K   E L+E ET A+ AE++ A +E+ 
Sbjct: 193 LEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKT 252

Query: 171 Y-------FAQKERDEAVMSRLQLAIEE 191
                   +AQK + +A+   L  A+ +
Sbjct: 253 IDDLEDEVYAQKMKYKAISEELDNALND 280



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 39/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)

Query: 255 KMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAK 314
           KM++   +    I+  + A +  K+ E     ++E+ Q     ++    E+  E+  +  
Sbjct: 7   KMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKG--TEDEVEKYSE-- 62

Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRE 374
             S+++A+E   Q  KK  +    +    SL++ +   E   D+    L+T   AL+  E
Sbjct: 63  --SVKEAQEKLEQAEKKATDAEADVA---SLNRRIQLVEEELDRAQERLAT---ALQKLE 114

Query: 375 NIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
                  +    +     +A+ +   MELQ    +EA  +A +  +K E   +V RK V
Sbjct: 115 EAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE---EVARKLV 170


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 83/352 (23%), Positives = 150/352 (42%), Gaps = 53/352 (15%)

Query: 104  TSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKL----KFKLELQEKETEAKI 159
            T D   E+    L+K++       ++L+ +L +++++QR L    K K+E+  K+ EA+I
Sbjct: 1582 TRDEQNEEKKRLLIKQV-------RELEAEL-EDERKQRALAVASKKKMEIDLKDLEAQI 1633

Query: 160  AEKTAALVEEVYFAQKERDEAVMSRLQLAIEE----RDEAIARAKHMEMSLKVLENINPE 215
                 A  E +   Q  + +A M   Q  +EE    RDE  A++K  E  LK LE     
Sbjct: 1634 EAANKARDEVI--KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLE----- 1686

Query: 216  ENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
               + LQE L     A      +++   + D I  +   K        SAL++E+    +
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDE--LADEITNSASGK--------SALLDEKRRLEA 1736

Query: 276  KCKRLEQELHHVKEQNQTSANNMRHLTAE----NNQERALKAKLLSMQQARETAVQQYKK 331
            +  +LE+EL   +   +   +  R  T +    N +  A ++       AR+   +Q K+
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796

Query: 332  LEEEIQTLRVYYS----------------LHKSLSQEENLKDQFNYTLSTYEEALKNREN 375
            L+ ++Q L                     L + L QE   +   N  +   E+ LK    
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856

Query: 376  IVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVD 427
             V   ++  ++   Q+++A      ++ QL+ A E +  AN   +KL+R +D
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 75/379 (19%), Positives = 165/379 (43%), Gaps = 49/379 (12%)

Query: 96   ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDK---EQRKLKFKLELQE 152
            EC +  Q+  + +K K +A +  + +++ +    L+++L KE+K   E  K K KL+ + 
Sbjct: 1010 ECSS--QLAEEEEKAKNLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGET 1064

Query: 153  KETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE 210
             + + +IAE  A + E ++  A+KE + +  ++R       ++ A+   + ++  +  L+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124

Query: 211  ---------NINPEENDMTLQELLNRI-----NNADTGIAIQKNGAIIVDRIYKTKECKM 256
                         E+    L E L  +     +  DT  A Q+        + + K+   
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 257  RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
              T    + + + R    +  + L ++L   K        N + L  + N+E A + K+L
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD-NKELACEVKVL 1243

Query: 317  SMQQARETAVQQYKKLEEEIQTL--------RVYYSLHKSLSQEENLKD----------- 357
              QQ +  +  + KKL+ ++Q L        R+   L +  S+ +N  D           
Sbjct: 1244 --QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301

Query: 358  ---QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQV 414
               +F    ++ E  L++ + ++    +Q   L+++++Q   E+ +++ Q +   EA + 
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361

Query: 415  ANEKVQKLERLVDVLRKKV 433
              ++V  L+  +   +KKV
Sbjct: 1362 LEKQVLALQSQLADTKKKV 1380



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 76/413 (18%), Positives = 177/413 (42%), Gaps = 35/413 (8%)

Query: 14   EQETTGINKSTQPD---EQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSY 70
            EQE   + K+ + +    +  +   +  H  + E ++E   +   +      N Q + + 
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET- 1231

Query: 71   PDDESVYCTTEKYNVM----EHRHNDMHYECMTPCQVTSDSDKEKT-----IAFLLKELD 121
             D++ + C  +    +    EH+   +  +        S+ D+ +       + L  ELD
Sbjct: 1232 -DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290

Query: 122  ILRTSNKKLQQKLAKEDKEQRKLKFKL----ELQEKETEAKI--AEKTAALVEEVYFAQK 175
             + T  ++ ++K  K  K+   L+ +L    EL ++ET  K+  + +   L EE    Q+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350

Query: 176  ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRI-NNADTG 234
            +++E   +R  L   E+     +++  +   KV +++   E+   L+E   ++  +A+  
Sbjct: 1351 QQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIES---LEEAKKKLLKDAEAL 1404

Query: 235  IAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHV-KEQNQT 293
                +  A+  D++ KTK  +++   ++++  ++ +    S  ++ +++   +  E+   
Sbjct: 1405 SQRLEEKALAYDKLEKTKN-RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 294  SANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEE 353
            SA           + R  + K LS+ +A E A++  ++ E + + LR        +    
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA------DMEDLM 1517

Query: 354  NLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
            + KD     +   E++ +  E  V   + Q EEL  +LQ     +  +E+ +Q
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570



 Score = 37.0 bits (84), Expect = 0.036
 Identities = 40/195 (20%), Positives = 79/195 (40%), Gaps = 19/195 (9%)

Query: 250  KTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQE- 308
            K K+ K+    EEM    E +   L + K +  E    + +    A  MR   A   QE 
Sbjct: 865  KEKQTKVEGELEEM----ERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920

Query: 309  ----RALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLS 364
                  L++++   ++  +    + KK++  IQ       L + L +EE  + +      
Sbjct: 921  EEILHDLESRVEEEEERNQILQNEKKKMQAHIQ------DLEEQLDEEEGARQKLQLEKV 974

Query: 365  TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL----QHAREASQVANEKVQ 420
            T E  +K  E  + + + QN +   + +      A    QL    + A+  +++ N++  
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 421  KLERLVDVLRKKVGT 435
             +  L + L+K+  T
Sbjct: 1035 MISDLEERLKKEEKT 1049


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1867

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1868 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1915

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2096 ARVQAEREAAQSRRQV 2111



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2034

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2152

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2210

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2268

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2269 EAEKMKQVAE 2278



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1383

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1429

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1550 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELER 1633



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1972 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2082

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2139

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2183

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2239

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2240 LSKLKARIEAENRALILRDKDNT 2262



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2170 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2288 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2399

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2400 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2250

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2251 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2301 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2418 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 431  KK 432
             K
Sbjct: 2471 LK 2472



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1755

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1756 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1813

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1814 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1856

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1857 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1913

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1914 EDTLRQR 1920



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1532

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1533 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1639

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1640 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 419  VQKL 422
             ++L
Sbjct: 1697 QRQL 1700



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2325 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1356 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1405

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1454

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1455 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1813 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1871

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1872 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1919

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2100 ARVQAEREAAQSRRQV 2115



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2038

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2156

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2214

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2272

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2273 EAEKMKQVAE 2282



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1387

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1433

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1554 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELER 1637



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1976 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2086

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2143

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2187

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2243

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2244 LSKLKARIEAENRALILRDKDNT 2266



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2174 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2292 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2403

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2404 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2254

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2255 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2305 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2422 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474

Query: 431  KK 432
             K
Sbjct: 2475 LK 2476



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1700

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1759

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1760 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1817

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1818 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1860

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1861 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1917

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1918 EDTLRQR 1924



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1536

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1537 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1643

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1644 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700

Query: 419  VQKL 422
             ++L
Sbjct: 1701 QRQL 1704



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2329 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1360 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1409

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1458

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1459 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1867

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1868 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1915

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2096 ARVQAEREAAQSRRQV 2111



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2034

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2152

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2210

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2268

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2269 EAEKMKQVAE 2278



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1383

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1429

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1550 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELER 1633



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1972 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2082

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2139

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2183

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2239

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2240 LSKLKARIEAENRALILRDKDNT 2262



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2170 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2288 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2399

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2400 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2250

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2251 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2301 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2418 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 431  KK 432
             K
Sbjct: 2471 LK 2472



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1755

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1756 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1813

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1814 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1856

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1857 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1913

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1914 EDTLRQR 1920



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1532

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1533 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1639

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1640 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 419  VQKL 422
             ++L
Sbjct: 1697 QRQL 1700



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2325 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1356 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1405

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1454

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1455 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1777 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1835

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1836 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1883

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2064 ARVQAEREAAQSRRQV 2079



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2002

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2120

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2178

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2236

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2237 EAEKMKQVAE 2246



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1351

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1397

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1518 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELER 1601



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1940 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2050

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2107

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2151

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2207

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2208 LSKLKARIEAENRALILRDKDNT 2230



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2138 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2256 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2367

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2368 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2218

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2219 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2269 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2386 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438

Query: 431  KK 432
             K
Sbjct: 2439 LK 2440



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1664

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1723

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1724 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1781

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1782 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1824

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1825 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1881

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1882 EDTLRQR 1888



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1500

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1501 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1607

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1608 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664

Query: 419  VQKL 422
             ++L
Sbjct: 1665 QRQL 1668



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2293 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1324 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1373

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1422

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1423 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1946 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 2004

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 2005 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 2052

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2233 ARVQAEREAAQSRRQV 2248



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2171

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2289

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2347

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2405

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2406 EAEKMKQVAE 2415



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1520

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1566

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1687 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELER 1770



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 2109 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2219

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2276

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2320

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2376

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2377 LSKLKARIEAENRALILRDKDNT 2399



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2307 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2425 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2536

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2537 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2387

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2388 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2438 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2555 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607

Query: 431  KK 432
             K
Sbjct: 2608 LK 2609



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1833

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1892

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1893 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1950

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1951 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1993

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1994 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 2050

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 2051 EDTLRQR 2057



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1669

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1670 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1776

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1777 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833

Query: 419  VQKL 422
             ++L
Sbjct: 1834 QRQL 1837



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2462 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1493 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1542

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1591

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1592 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1787 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1845

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1846 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1893

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2074 ARVQAEREAAQSRRQV 2089



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2012

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2130

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2188

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2246

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2247 EAEKMKQVAE 2256



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1361

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1407

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1528 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELER 1611



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1950 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2060

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2117

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2161

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2217

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2218 LSKLKARIEAENRALILRDKDNT 2240



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2148 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2266 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2377

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2378 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2228

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2229 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2279 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2396 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448

Query: 431  KK 432
             K
Sbjct: 2449 LK 2450



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1674

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1733

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1734 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1791

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1792 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1834

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1835 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1891

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1892 EDTLRQR 1898



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1510

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1511 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1617

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1618 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674

Query: 419  VQKL 422
             ++L
Sbjct: 1675 QRQL 1678



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2303 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1334 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1383

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1432

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1433 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1795 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1853

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1854 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1901

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2082 ARVQAEREAAQSRRQV 2097



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2020

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2138

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2196

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2254

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2255 EAEKMKQVAE 2264



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1369

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1415

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1536 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELER 1619



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1958 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2068

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2125

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2169

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2225

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2226 LSKLKARIEAENRALILRDKDNT 2248



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2156 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2274 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2385

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2386 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2236

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2237 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2287 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2404 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456

Query: 431  KK 432
             K
Sbjct: 2457 LK 2458



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1682

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1741

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1742 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1799

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1800 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1842

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1843 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1899

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1900 EDTLRQR 1906



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1518

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1519 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1625

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1626 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682

Query: 419  VQKL 422
             ++L
Sbjct: 1683 QRQL 1686



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2311 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1342 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1391

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1440

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1441 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)

Query: 134  LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
            LA+E K QR+L  +    Q  E E  +AEK AA+ E      E   A KE+ EA   RL+
Sbjct: 1836 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1894

Query: 187  LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
               E  DEA  R +  E +          ++   ++E L ++  A     +++   ++ D
Sbjct: 1895 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1942

Query: 247  RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
             + + ++ +  I A     E+ +A   E +  L + +   ++    KEQ +  A   R L
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 302  TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
             AE  + R   + ++     A E A +Q K   EE++ L+      + L +  E+    Q
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
                    ++ L+  E   +   QQ E EL   LQQ  +    +  + + AR A++ A E
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122

Query: 418  KVQKLERLVDVLRKKV 433
               + ER     R++V
Sbjct: 2123 ARVQAEREAAQSRRQV 2138



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)

Query: 124  RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
            R + +++Q+ LA E++  R+ K  LE           E+  A VEE    ++  ++    
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2061

Query: 184  RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
            +LQLA E   +R +A  +A    +  K  E     + + ++ + L     A    A +  
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A +       +  +    AE +    EE+  A ++ +   ++L   KE  Q +A   + 
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2179

Query: 301  LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
              A   Q++A  A++   ++  E  ++Q  ++E+E+ TLR+   L ++  Q+  L ++  
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2237

Query: 361  YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
               +   EA + R  +   +   + Q EEL+    +A  E  N  L L+      +   E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2295

Query: 418  KVQKLERLVD 427
            + +K++++ +
Sbjct: 2296 EAEKMKQVAE 2305



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)

Query: 113  IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
            I F+ + L  +    +  +Q+ A+E +   +++  LE Q +  EA    K          
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1410

Query: 173  AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
            AQ ER+ + +  R+Q  +  R+EA   A+  + S++              +EL     ++
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1456

Query: 232  DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
            +  I  +   A   +R     E ++R+   ++ A   +R  A  + + L    +E    K
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516

Query: 289  EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
             Q Q  A  + R +  E+ ++R  + +L S  +A   A ++ ++  + ++ LR+      
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576

Query: 347  KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
            + L Q E   ++        E A ++ E  +   +    E   QL+++L E        R
Sbjct: 1577 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634

Query: 399  ANMELQLQHAREASQVANEKVQKLER 424
               E + Q   EA +   E  ++LER
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELER 1660



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
            Q++LA E++ +R+     E +E+  ++  AE+ AA   +    + ER +A +   +   E
Sbjct: 1999 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053

Query: 191  ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
              ++  AR   +     +  L+  E  +    ++ +  LQ+ L +    +  +  Q  G 
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2109

Query: 243  IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
                R    +  + R+ AE  +A    +     + K+  +E    + Q Q +A  +R   
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2166

Query: 303  AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
             E  QE A +A+     L  +QA +  ++++KK  E  QTLR               K Q
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2210

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L+T    L+  ++  ++  ++ + L  +  +A  +R+ +E +L   R    V  E+
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2266

Query: 419  VQKLERLVD------VLRKKVGT 435
            + KL+  ++      +LR K  T
Sbjct: 2267 LSKLKARIEAENRALILRDKDNT 2289



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)

Query: 10   HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
            H    ++T  + +  Q +++LT   +  E++ H+K+   E +  +  E TE   QRS   
Sbjct: 2197 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254

Query: 65   QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
            + + S           +     E+R   +  +  T   +  +++K K +A     L +  
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314

Query: 125  TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
                +L+Q LA+ED  Q++   +  L+EK    +  ++   L  E    Q++++ A    
Sbjct: 2315 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 185  LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
             +L  ++   A   A+  +   + LE     + +M+ +    ++  A+   A  +     
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2426

Query: 245  VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
                 +    + R  AEE+   +   + A  +   L Q L   ++Q+   A  +R   AE
Sbjct: 2427 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481

Query: 305  NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
              +E+     +AKLL ++      VQQ + L+E     + + S   SL Q E   +Q   
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541

Query: 362  TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
             L                                 ++ EEA + +       +++ EEL 
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601

Query: 389  TQLQQALTERANMELQLQHAREASQVANEK 418
               QQ   +   +  + Q  RE  Q+  E+
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)

Query: 133  KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
            +L  E+ + +K     ELQ  + EA  A +  + VEE  F+ + + E  +S+L+  IE  
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2277

Query: 193  DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
            + A+           + +  N +       E + ++      +++    A  + ++ +  
Sbjct: 2278 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327

Query: 253  ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
              + R  AE+M   ++E+  A+ +  RL+ E   +++Q + +    R L  +  Q  + L
Sbjct: 2328 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384

Query: 312  KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
              +    Q+  E   Q+  ++  E + L++  + + ++ ++ E    +F        E L
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444

Query: 371  KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
                     T+   +E  T +Q    +R   +   +  REA      + +KL++   +L+
Sbjct: 2445 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497

Query: 431  KK 432
             K
Sbjct: 2498 LK 2499



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)

Query: 126  SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
            +N+ L+ +L  E+  Q+K   + E ++++ EA+   +     EE    Q+E  E  + + 
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1723

Query: 186  QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
            Q  + E       A   E+     E    E+    L+E L R+   +   A QK   +  
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1782

Query: 246  DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
            +      E ++ + A +  A  E R  +    +RLE E    +E  + +A  +R L  E 
Sbjct: 1783 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1840

Query: 306  NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
             ++R         Q A E A +Q  + E      RV      ++ +   LK +    L  
Sbjct: 1841 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1883

Query: 366  YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
             +E     E +  + + +  +     +QA   +A++E +L   R+AS    E+ + L  +
Sbjct: 1884 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1940

Query: 426  VDVLRKK 432
             D LR++
Sbjct: 1941 EDTLRQR 1947



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)

Query: 131  QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
            Q++  +E+ +Q +   + E+Q K  +A+ AE++   +EE   V   Q E  E        
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500

Query: 184  RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
             LQ      +EA A+ +  +   + L     +E+    Q   EL +R+  A+   A +K 
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1559

Query: 241  GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
             A+           ++R+ AEE    +  R A + + ++++  L   +   +    + R 
Sbjct: 1560 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 301  LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
              AE     ER+L+ + +++ Q RE A    ++ +++ +  R      + L + + LK  
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1666

Query: 359  FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
                L    E +  ++   S+ Q + E+   + ++    R   E Q    RE ++   EK
Sbjct: 1667 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723

Query: 419  VQKL 422
             ++L
Sbjct: 1724 QRQL 1727



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)

Query: 116  LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
            L  E ++L+   K+L Q+ A+   EDKEQ   +   E Q      E E + ++     AE
Sbjct: 2352 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410

Query: 162  KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
            +    V E+  AQ   +E    R +   EE  E + R   A   +++L     I  +++D
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469

Query: 219  MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
               + L   I   +     +Q+   ++  +  + +  +     +E  AL    + E+D+ 
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529

Query: 274  LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
            L + + +EQE   +++  Q      + L  E  +     E+  +  + SM++AR     A
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589

Query: 326  VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
             +  ++ +EE+Q L       + L  EEN  L++Q       +  AL + E + +
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)

Query: 260  AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
            AEE   L E  +AAL K ++L +     K Q +  A  +         ++ ++ +++  +
Sbjct: 1383 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1432

Query: 320  QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
            +A   A QQ + ++EE+Q LR         S E  ++ +     +     L+  E I   
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1481

Query: 380  TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
                   +  QL+    +R   E +LQ  R  ++ A  + ++ +   + LR++V   + R
Sbjct: 1482 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.123    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,042,544
Number of Sequences: 37866
Number of extensions: 588637
Number of successful extensions: 6716
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 823
Number of HSP's that attempted gapping in prelim test: 3977
Number of HSP's gapped (non-prelim): 2595
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.