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Search of human proteins with 23397572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23397572 kelch-like 34 [Homo sapiens]
(644 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23397572 kelch-like 34 [Homo sapiens] 1300 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 280 4e-75
gi|45643138 kelch-like 13 [Homo sapiens] 276 4e-74
gi|31542246 kelch-like 36 [Homo sapiens] 263 5e-70
gi|156616301 kelch-like 32 [Homo sapiens] 238 1e-62
gi|8922854 kelch-like 26 [Homo sapiens] 228 1e-59
gi|55741643 kelch-like 14 [Homo sapiens] 217 3e-56
gi|226442729 kelch-like 15 [Homo sapiens] 206 4e-53
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 203 5e-52
gi|24432026 kelch-like [Homo sapiens] 175 1e-43
gi|166235129 kelch-like 3 [Homo sapiens] 170 4e-42
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 166 6e-41
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 166 6e-41
gi|40807500 kelch-like 20 [Homo sapiens] 164 2e-40
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 160 3e-39
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 157 4e-38
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 157 4e-38
gi|14780904 kelch-like 1 protein [Homo sapiens] 156 5e-38
gi|55925608 kelch-like 21 [Homo sapiens] 154 2e-37
gi|38194229 kelch-like 17 [Homo sapiens] 154 3e-37
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 152 9e-37
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 152 9e-37
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 151 2e-36
gi|223890235 intracisternal A particle-promoted polypeptide isof... 149 8e-36
gi|11056006 kelch-like 12 [Homo sapiens] 148 2e-35
gi|34101268 kelch-like 8 [Homo sapiens] 147 2e-35
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 141 2e-33
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 139 1e-32
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 138 1e-32
gi|128485503 kelch-like 30 [Homo sapiens] 136 5e-32
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 1300 bits (3364), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS 60
MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS
Sbjct: 1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS 60
Query: 61 HTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
HTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR
Sbjct: 61 HTQESRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGR 120
Query: 121 YLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLR 180
YLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLR
Sbjct: 121 YLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLR 180
Query: 181 AVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGS 240
AVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGS
Sbjct: 181 AVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGS 240
Query: 241 GLVLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAA 300
GLVLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAA
Sbjct: 241 GLVLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAA 300
Query: 301 PQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHS 360
PQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHS
Sbjct: 301 PQRAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHS 360
Query: 361 VCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWC 420
VCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWC
Sbjct: 361 VCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWC 420
Query: 421 GAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISG 480
GAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISG
Sbjct: 421 GAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISG 480
Query: 481 GKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE 540
GKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE
Sbjct: 481 GKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE 540
Query: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD
Sbjct: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
Query: 601 RWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGEALDLVLG 644
RWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGEALDLVLG
Sbjct: 601 RWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGEALDLVLG 644
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 280 bits (715), Expect = 4e-75
Identities = 194/621 (31%), Positives = 294/621 (47%), Gaps = 70/621 (11%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLET-EGSE-FPAHRSLLACSSDYFRALFKSHTQESRAR 68
H +L G+ LR EG LCDVTL +G E FP HR+++A +SDYF+A+F +E
Sbjct: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
Query: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
I LH + GL++++DFIYTA LSL+MD ++DTLEAAS+LQ+ L C +L ++
Sbjct: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
Query: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
+NC +A + L I+ + LL+ G L+L L VL + +
Sbjct: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE----FLKLPFERLAFVLSSNSL 207
Query: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPAR 247
E L A WLR E R+ + +L++ +RF L+ P D++ V + +
Sbjct: 208 KHCTELELFKAACRWLRLE--DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNT 265
Query: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
L+++A NY P QP+MQ ++T+IRS T ++ +GG +++V+
Sbjct: 266 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVV------------ 313
Query: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
+E + +E +E WRSL + P H + GNF
Sbjct: 314 --------SKELRMYDERAQE-----------------WRSLAPMDAPRYQHGIAVIGNF 348
Query: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
L+V+GG+S + D V R+DPR++ W +V ++ E R F A+ L
Sbjct: 349 LYVVGGQSNYDTKGKTAVD-------TVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHL 401
Query: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
AVGG A GE LA+VE Y+ R + W+ + +GHAG V G++YISGG
Sbjct: 402 YAVGGRSAAGE-LATVECYNPRMNEWSYVAKMSEPHYGHAGTVYG-GLMYISGGIT---- 455
Query: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTAR-------FGHHMAVLRGAVFAFLGRYEPFSE 540
+ +L P+ W +KAPM T R G + V+ G F Y+
Sbjct: 456 -HDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514
Query: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
E Y P DQWT + + + G+AV E ++GG W + V V YD + D
Sbjct: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI--VQKYDPEKD 572
Query: 601 RWEDIGCALPWAWSGLRCAVL 621
W + LP + G+R L
Sbjct: 573 EWHKV-FDLPESLGGIRACTL 592
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 276 bits (706), Expect = 4e-74
Identities = 190/621 (30%), Positives = 288/621 (46%), Gaps = 70/621 (11%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSE--FPAHRSLLACSSDYFRALFKSHTQESRAR 68
H +L G+ LR EG LCDVTL ++ FP HR ++A +SDYF+A+F +E
Sbjct: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
Query: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
I LH S GL++++DFIYTA LSL+MD ++DTLEAAS+LQ+ L C +L +
Sbjct: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
Query: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
+NC +A + L ++ + LL+ G L+L L VL + +
Sbjct: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGE----FLKLPFERLAFVLSSNSL 249
Query: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPAR 247
E L WLR E R+ +L++ +RF L+ P +++ V + +
Sbjct: 250 KHCTELELFKATCRWLRLE--EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNT 307
Query: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
L+++A NY P QP+MQ ++T+IRS T ++ +GG +++V+
Sbjct: 308 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV------------ 355
Query: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
++ + +D H W+SL + P H + GNF
Sbjct: 356 -------------------------SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNF 390
Query: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
L+V+GG+S + D V R+DPR++ W +V ++ E R F A+ L
Sbjct: 391 LYVVGGQSNYDTKGKTAVD-------TVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 443
Query: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
AVGG A GE L +VE Y+ R + WT + +GHAG V GV+YISGG
Sbjct: 444 YAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG-GVMYISGGIT---- 497
Query: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTAR-------FGHHMAVLRGAVFAFLGRYEPFSE 540
+ ++L P+ W +KAPM T R G + V+ G F Y+
Sbjct: 498 -HDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556
Query: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
E Y P DQWT + + + G+AV E ++GG W + V V YD D D
Sbjct: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI--VQKYDPDKD 614
Query: 601 RWEDIGCALPWAWSGLRCAVL 621
W + LP + G+R L
Sbjct: 615 EWHKV-FDLPESLGGIRACTL 634
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 263 bits (671), Expect = 5e-70
Identities = 193/641 (30%), Positives = 294/641 (45%), Gaps = 73/641 (11%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H +L R G CDV L + PAHR+LLA SDYF ++F +E+ + +
Sbjct: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
L S GL+ ++DF+Y L L ++ LE A LQ+ + C YLE++++ +N
Sbjct: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
+ +A+ + L + I++H L P L ++ L L + +V R
Sbjct: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTL---SFTPDFLQNVSMQKLCVYLSSSEVQR 204
Query: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLP--AR 247
E LL AL WL Q+P ER AH ++LE + F L+P D+L RV +LP A
Sbjct: 205 ECEHDLLQAALQWLTQQP--EREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEAN 262
Query: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
+G I +A+ YH + QP+MQ ++T++R+ Q R+L VGG
Sbjct: 263 CEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGG-------------------- 302
Query: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
E E EL+ + D + +W T LP H V G F
Sbjct: 303 ----------------EVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGF 346
Query: 368 LFVLGG---ESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVG 424
+F+ GG G A+S L ++RYDPR W +V +M + R F+ ++
Sbjct: 347 IFIAGGSFSRDNGGDAASNL----------LYRYDPRCKQWIKVASMNQRRVDFYLASIE 396
Query: 425 ERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAG 484
+ L+A+GG G L+SVE Y + D W+ LPR +GHAG + + VYISG G
Sbjct: 397 DMLVAIGGRNENG-ALSSVETYSPKTDSWSYVAGLPRFTYGHAGTI-YKDFVYISG---G 451
Query: 485 RGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERY 544
++L VW ++ PM TAR H M L ++++ G + +ER+
Sbjct: 452 HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERF 511
Query: 545 D--------PGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYD 596
D P +QWTR+ PL + G+AV E +LGG W ++ T V YD
Sbjct: 512 DVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQV--YD 569
Query: 597 LDLDRWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGE 637
+ D+W G LP A +G V L +D+++ G+
Sbjct: 570 READKWSR-GVDLPKAIAGGSACVCALEPRPEDKKKKGKGK 609
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 238 bits (608), Expect = 1e-62
Identities = 187/629 (29%), Positives = 289/629 (45%), Gaps = 61/629 (9%)
Query: 5 LSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQE 64
L + ++H ++L R++G LCD+TL E +F AH+++LA SDYFRA+F E
Sbjct: 18 LCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVE 77
Query: 65 SRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLER 124
S A ++LH ++ GL++ L+F YT + L ++D L A S+LQ+ E L LC YL +
Sbjct: 78 SGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 137
Query: 125 QLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLG 184
+L N +A F L A +V HL ELL + P +L L L+ VL
Sbjct: 138 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLK--SRPEEVLTLPYCLLQEVLK 195
Query: 185 APDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVL 244
+ + + E ++ LA+ WL + ELL+ +RFGL+ D L V LV
Sbjct: 196 SDRLTSLSEEQIWQLAVRWLEHNC---HYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQ 252
Query: 245 PAR-VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQR 303
+ L+ +AL YH + QP+ Q +T R + ++GG++ ++E+
Sbjct: 253 ASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKEL----- 307
Query: 304 AARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCT 363
+ P +E N + + N W L +P H V
Sbjct: 308 ----RYFNPVDQE------------------NALIAAIAN--WSELAPMPVGRSHHCVAV 343
Query: 364 AGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
G+FLFV GGE S + RYDPR ++W E+ M+ R HF GA+
Sbjct: 344 MGDFLFVAGGEVEHASGRT-------CAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAM 396
Query: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
E L AVGG +VL +VE Y ++++WT + R+L HAG V D G+++ISGG
Sbjct: 397 EEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVAD-GLLWISGGVT 455
Query: 484 GRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFS---- 539
A L V P + W ++PM R H MA ++ ++ G ++
Sbjct: 456 NT----AQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRI 511
Query: 540 ---EIERYDPGADQWTRLR-PLPYDRFCYGLAVVEETALLLGGLK-WRDSRQVPTRNVVG 594
I+ Y+ DQWTR L + G+AV L+GG W + P +
Sbjct: 512 LVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNE---PLACIQV 568
Query: 595 YDLDLDRWEDI--GCALPWAWSGLRCAVL 621
D+ + E++ G LP+A +G+ L
Sbjct: 569 LDVSREGKEEVFYGPTLPFASNGIAACFL 597
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 228 bits (581), Expect = 1e-59
Identities = 182/630 (28%), Positives = 274/630 (43%), Gaps = 73/630 (11%)
Query: 10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV 69
+H +LL G LRA+G L DV L FPAH+ +LA SDYFRA+F +E+ V
Sbjct: 44 SHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV 103
Query: 70 IHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129
I L SA GL+ ++DF Y+A ++L +D V+D L AA +LQ+ + LC +L+ ++ E
Sbjct: 104 IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVE 163
Query: 130 NCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVA 189
C +A F LA ++ + H ++ A L L L L + +
Sbjct: 164 TCLNIGQMATTFSLASLRESVDAFTFRHFLQI----AEEEDFLRLPLERLVFFLQSNRLQ 219
Query: 190 RVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPARV 248
E L A+ WL+ +P R + +L +RF L+ ++++ V + +V
Sbjct: 220 SCAEIDLFRAAVRWLQHDPA--RRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
Query: 249 KGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308
+ +++A NY P RQ MQ +T++RS ++ GG + R+ +
Sbjct: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTD--------SDRSVSSK 329
Query: 309 V-AAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
V PEP +R LT++ V NF
Sbjct: 330 VYQLPEPGA---------------------------RHFRELTEMEVGCSHTCVAVLDNF 362
Query: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
++V GG+ + D +RYDP + W + AM+E+R F + +
Sbjct: 363 VYVAGGQHLQYRSGEGAVD-------ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMV 415
Query: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
A GG G LASVE Y RR+ W A +L R GHAGA G +YISGG E
Sbjct: 416 YATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHAGAASG-GRLYISGGYGISVE 473
Query: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE------I 541
+ L+ P W KAPM R H M G ++A GR + +
Sbjct: 474 ----DKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAV 529
Query: 542 ERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVG----YDL 597
E Y P DQWT + P+ + G ++E ++GG WR NV G Y+
Sbjct: 530 EYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWR------LNNVTGIVQVYNT 583
Query: 598 DLDRWEDIGCALPWAWSGLRCAVLQLAEGG 627
D D WE P +++G+ CA + L G
Sbjct: 584 DTDEWER-DLHFPESFAGIACAPVLLPRAG 612
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 217 bits (552), Expect = 3e-56
Identities = 163/517 (31%), Positives = 251/517 (48%), Gaps = 78/517 (15%)
Query: 76 SAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAA 135
S+ GL+ +L+++YTA ++LS+DTVE+ L + L + + LC ++L Q++ +N
Sbjct: 131 SSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVC 190
Query: 136 NVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEAR 195
+AA GL T A + +V +L LN +RA+L + E
Sbjct: 191 KIAALHGLEETKKLANKYLVE-------------DVLLLNFEEMRALLDSLPPPVESELA 237
Query: 196 LLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLPARVKGLIIQ 254
L +++ WL + T R+ + +L++R+RF L+PA +++ RV S + + L++
Sbjct: 238 LFQMSVLWLEHDRET-RMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLD 296
Query: 255 ALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEP 314
A+NYH P RQ Q + IRS + +LLVGG P P
Sbjct: 297 AMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGG----------------------LPPGP 334
Query: 315 EEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGE 374
+ L + ++E+ W+ LT +P H V NFLFVLGGE
Sbjct: 335 DRLPSNLVQYYDDEK--------------KTWKILTIMPYNSAHHCVVEVENFLFVLGGE 380
Query: 375 ---SPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVG 431
+P+G S T V RYDPRF++W ++P M+E RA F+ + + L +G
Sbjct: 381 DQWNPNGKHS----------TNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIG 430
Query: 432 GLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGAS 491
G G L+SVE Y+L + W +LP+ L HAGAV G +YISGG GE
Sbjct: 431 GRNETG-YLSSVECYNLETNEWRYVSSLPQPLAAHAGAV-HNGKIYISGG-VHNGE---- 483
Query: 492 SLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRY-EPFSE-----IERYD 545
+ LY P VW++K M T R H +AV+ ++A G + + FS +E YD
Sbjct: 484 YVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYD 543
Query: 546 PGADQWTRLR-PLPYDRFCYGLAVVEETALLLGGLKW 581
P DQW L+ P+ R G AV++++ L+GG W
Sbjct: 544 PKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSW 580
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 206 bits (525), Expect = 4e-53
Identities = 174/650 (26%), Positives = 284/650 (43%), Gaps = 84/650 (12%)
Query: 7 YCKA-HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQES 65
+C + H ++ G++AL EG L DVTL E +F AH++LLA SDYFR +F + +E
Sbjct: 8 FCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRER 67
Query: 66 RARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQ 125
IHL +A G +L F+Y + LSM+TV + L+AA Y+Q+ E + C +L +
Sbjct: 68 DQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAK 127
Query: 126 LAPENCCFAANVAARFG--LAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVL 183
+ ENC + FG + + + ++ + L++R P L L+ L + L
Sbjct: 128 ICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSR---PDFLSYLSFEKLMSYL 184
Query: 184 GAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGL 242
++R PE L +WLR + R H +++ +RF L+ P V +V +
Sbjct: 185 DNDHLSRFPEIELYEAVQSWLRHD--RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFY 242
Query: 243 VLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQ 302
+++ + QALNY +QPL+ + + IRS + + + G +V ++
Sbjct: 243 RYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKI---- 298
Query: 303 RAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVC 362
L ++ WEL V PL +
Sbjct: 299 ------------------LLLKKPRVWWELEGPQV-----------------PLRPDCLA 323
Query: 363 TAGNFLFVLGGE--SPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWC 420
NF+F+LGGE P G + +++V RYDPR ++W ++ M R+ F
Sbjct: 324 IVNNFVFLLGGEELGPDGEFHA---------SSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
Query: 421 GAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISG 480
G +G+ + AV G E S E YD+ D+W P +GH G V + ++I+G
Sbjct: 375 GVIGKFIYAVAG-RTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLN-NKLFITG 432
Query: 481 GKAGRGEGGASSLRDLYVLGPEEQ----------VWSKKAPMGTARFGHHMAVLRGAVFA 530
G + D G EQ W K+ M AR H M G ++
Sbjct: 433 GITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYV 492
Query: 531 FLG---------RYEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKW 581
F G + E Y+P DQWT L +P R +G+ V+++ ++LGGL +
Sbjct: 493 FGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCY 552
Query: 582 RDSRQVPTRNVVGYDLDLDRW-EDIGCALPWAWSGLRCAVLQLAEGGDDE 630
+ +++ +D D ++W ED +P GL+ L + DE
Sbjct: 553 NGHY---SDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDE 599
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 203 bits (516), Expect = 5e-52
Identities = 162/622 (26%), Positives = 265/622 (42%), Gaps = 69/622 (11%)
Query: 10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV 69
++G LL G +R E FLCD+ + T+ F H+S++A S+YF + K R
Sbjct: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR--- 110
Query: 70 IHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129
+ L+ S GL ++ + YT L+LS+ T+ + AA YLQ+ + +C +L R+++ E
Sbjct: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
Query: 130 NCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVA 189
NC + N+A + L + AA++ I + E A ++L + +L D+
Sbjct: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEF----AESDQFMKLTFEQINELLIDDDLQ 226
Query: 190 RVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLPARV 248
E +A+ WL E +R+ + +LL +RFG + A D++ V S ++ A
Sbjct: 227 LPSEIVAFQIAMKWL--EFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADC 284
Query: 249 KGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308
L++ A+NYH P Q +Q +T IR ++ VGGR
Sbjct: 285 HRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGR-------------------- 324
Query: 309 VAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFL 368
P E+ L + + + + W LT++P V FL
Sbjct: 325 -----PGLTEKSLSRD------------ILYRDPENGWSKLTEMPAKSFNQCVAVMDGFL 367
Query: 369 FVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLL 428
+V GGE + + + ++ + RYDPRF+ W + +M + R HF +
Sbjct: 368 YVAGGEDQNDA-----RNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVY 422
Query: 429 AVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEG 488
A GG A G LAS+E Y ++W L A HA AV D G V ++GG
Sbjct: 423 AAGGRNAEGS-LASLECYVPSTNQWQPKTPLEVARCCHASAVAD-GRVLVTGGYIANAYS 480
Query: 489 GASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLG-RYEPFSE------I 541
R + P W + + T R H L V+ G + P E +
Sbjct: 481 -----RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTV 535
Query: 542 ERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDR 601
E Y P QW+ PL G++ + A L+GG W + + + + + +L+
Sbjct: 536 ECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGG--WNEGEKKYKKCIQCFSPELNE 593
Query: 602 WEDIGCALPWAWSGLRCAVLQL 623
W + LP A G+ C L +
Sbjct: 594 WTE-DDELPEATVGVSCCTLSM 614
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 175 bits (443), Expect = 1e-43
Identities = 166/624 (26%), Positives = 262/624 (41%), Gaps = 73/624 (11%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H ALL G ALR G L DV L EG AHR LLA S DYFR +F +E +
Sbjct: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEV 91
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
+H S + ++L FIYT+ L LS+ V++TL AA LQ+ E + C +L + EN
Sbjct: 92 LIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 151
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
+A F L+ + + I+ + + +L + ++L + +
Sbjct: 152 ILDVYRLAELFDLSRLTEQLDTYILKNFVAF----SRTDKYRQLPLEKVYSLLSSNRLEV 207
Query: 191 VPEARLLGLALAW---LRQEPTTERLAH-CTELLERVRFGLVPADVLRRVYSGSGLVLPA 246
E + AL + L Q + H +LLE VRF L+ A+VL+R++ + P+
Sbjct: 208 SCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHD---KLDPS 264
Query: 247 RVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAAR 306
++ + AL YH S QP +Q QT +RS ++ GG + P
Sbjct: 265 PLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIH---------STPSTVLS 315
Query: 307 GQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGH-SVCTAG 365
Q P E W+ T P + + +
Sbjct: 316 DQAKYLNPLLGE---------------------------WKHFTASLAPRMSNQGIAVLN 348
Query: 366 NFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGE 425
NF++++GG++ + ++ RYDPR + W ++ ++++ A VG
Sbjct: 349 NFVYLIGGDNNVQGFRA---------ESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGR 399
Query: 426 RLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGR 485
+ AV G + L +VE YD + W L R ++ HAGA + G +YI+ G+ G
Sbjct: 400 YIYAVAGRDYHND-LNAVERYDPATNSWAYVAPLKREVYAHAGATLE-GKMYITCGRRGE 457
Query: 486 GEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAF------LGRYEPFS 539
L++ + P W A R H MA L ++ G
Sbjct: 458 -----DYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVH 512
Query: 540 EIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDL 599
++ Y + QW+ + PLP G+AV++ +LGG +R T V YD++
Sbjct: 513 QVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRS--HNRGSRTGYVHIYDVEK 570
Query: 600 DRWEDIGCALPWAWSGLRCAVLQL 623
D WE+ G L + SGL VL L
Sbjct: 571 DCWEE-GPQLDNSISGLAACVLTL 593
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 170 bits (430), Expect = 4e-42
Identities = 153/599 (25%), Positives = 243/599 (40%), Gaps = 71/599 (11%)
Query: 10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV 69
AH G LR++ LCDV + E E AHR +LA S YF A+F ES+A+
Sbjct: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
Query: 70 IHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129
I + L +L+D+IYTA + ++ + V+ L AAS LQ+ + C +L+ QL P
Sbjct: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
Query: 130 NCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVA 189
NC A L A H E++ L L+ + +++ + +
Sbjct: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVML----GEEFLSLSLDQVCSLISSDKLT 206
Query: 190 RVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARV- 248
E ++ ++W+ E T RL H +L+E VR L+P D L + L+
Sbjct: 207 VSSEEKVFEAVISWINYEKET-RLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTC 265
Query: 249 KGLIIQALNYHTTPSRQPLM-QGEQTSIRSPQT--RILLVGGRRAREVVIEEVAAPQRAA 305
K +I+A+ YH P Q L+ + +T R+P + ++++V G +A + +
Sbjct: 266 KDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAI----------- 314
Query: 306 RGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAG 365
++V +D RW + +LP+ V
Sbjct: 315 ----------------------------RSVECYDFEEDRWDQIAELPSRRCRAGVVFMA 346
Query: 366 NFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGE 425
++ +GG + S RV T V YD WT + +M+E R+ + +
Sbjct: 347 GHVYAVGGFNGS----------LRVRTVDV--YDGVKDQWTSIASMQERRSTLGAAVLND 394
Query: 426 RLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGR 485
L AVGG G LASVE Y + + W + G G +Y GG G
Sbjct: 395 LLYAVGGFD-GSTGLASVEAYSYKTNEWFFVAPM-NTRRSSVGVGVVEGKLYAVGGYDGA 452
Query: 486 GEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPF--SEIER 543
S++ P W A M T R G + VL G ++A G P +E
Sbjct: 453 SRQCLSTVEQ---YNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEV 509
Query: 544 YDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
YDPG + W ++ + R G+ V ++GG D +V Y+ D+W
Sbjct: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG----DDGSCNLASVEYYNPVTDKW 564
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/119 (28%), Positives = 46/119 (38%), Gaps = 13/119 (10%)
Query: 336 VVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQV 395
V ++ + W + + T G V L+ GG D +V V
Sbjct: 460 VEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGH------------DGPLVRKSV 507
Query: 396 HRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWT 454
YDP + W +V M R + AV L VGG G LASVE Y+ D+WT
Sbjct: 508 EVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWT 565
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 166 bits (420), Expect = 6e-41
Identities = 150/588 (25%), Positives = 246/588 (41%), Gaps = 73/588 (12%)
Query: 22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQ 81
LR++ LCDVT+ E E AHR +LA S YF A+F ESRA+ + + L+
Sbjct: 53 LRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLR 112
Query: 82 RLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARF 141
L+D++YTA + ++ + V+ L AA LQ+ + C +LE QL P NC A
Sbjct: 113 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 172
Query: 142 GLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLAL 201
L+ A H +++ L L + +++ + + E ++ +
Sbjct: 173 ACTDLLNKANTYAEQHFADVVL----SEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228
Query: 202 AWLRQEPTTERLAHCTELLERVRFGLVPADVL-RRVYSGSGLVLPARVKGLIIQALNYHT 260
AW+ + R L+E VR L+P + L +RV + + + K +I+A+ YH
Sbjct: 229 AWVNHDKDV-RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHL 287
Query: 261 TPSRQP-LMQGEQTSIRSPQT--RILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEE 317
P+ Q LM+ +T +R+P ++++V G +A + +
Sbjct: 288 LPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAI----------------------- 324
Query: 318 EEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPS 377
++V +D RW + +LP+ + +F +GG + S
Sbjct: 325 ----------------RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 368
Query: 378 GSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGG 437
RV T V YDP WT V MR+ R+ + L AVGG G
Sbjct: 369 ----------LRVRT--VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD-GS 415
Query: 438 EVLASVEMYDLRRDRWTAAGAL-PRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDL 496
L+SVE Y+++ + W + R G VG G++Y GG G S++ +
Sbjct: 416 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG--GLLYAVGGYDGASRQCLSTV-EC 472
Query: 497 YVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPF--SEIERYDPGADQWTRL 554
Y E W+ A M T R G + VL ++A G P +E YDP + W ++
Sbjct: 473 YNATTNE--WTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 530
Query: 555 RPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
+ R G+ V ++GG D +V Y+ D+W
Sbjct: 531 ADMNMCRRNAGVCAVNGLLYVVGG----DDGSCNLASVEYYNPTTDKW 574
Score = 53.1 bits (126), Expect = 8e-07
Identities = 38/133 (28%), Positives = 54/133 (40%), Gaps = 13/133 (9%)
Query: 336 VVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQV 395
V ++ + W + ++ T G V N L+ +GG D +V V
Sbjct: 470 VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH------------DGPLVRKSV 517
Query: 396 HRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTA 455
YDP +AW +V M R + AV L VGG G LASVE Y+ D+WT
Sbjct: 518 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTV 576
Query: 456 AGALPRALHGHAG 468
+ +AG
Sbjct: 577 VSSCMSTGRSYAG 589
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 166 bits (420), Expect = 6e-41
Identities = 150/588 (25%), Positives = 246/588 (41%), Gaps = 73/588 (12%)
Query: 22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQ 81
LR++ LCDVT+ E E AHR +LA S YF A+F ESRA+ + + L+
Sbjct: 49 LRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLR 108
Query: 82 RLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARF 141
L+D++YTA + ++ + V+ L AA LQ+ + C +LE QL P NC A
Sbjct: 109 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 168
Query: 142 GLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLAL 201
L+ A H +++ L L + +++ + + E ++ +
Sbjct: 169 ACTDLLNKANTYAEQHFADVVL----SEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
Query: 202 AWLRQEPTTERLAHCTELLERVRFGLVPADVL-RRVYSGSGLVLPARVKGLIIQALNYHT 260
AW+ + R L+E VR L+P + L +RV + + + K +I+A+ YH
Sbjct: 225 AWVNHDKDV-RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHL 283
Query: 261 TPSRQP-LMQGEQTSIRSPQT--RILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEE 317
P+ Q LM+ +T +R+P ++++V G +A + +
Sbjct: 284 LPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAI----------------------- 320
Query: 318 EEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPS 377
++V +D RW + +LP+ + +F +GG + S
Sbjct: 321 ----------------RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 364
Query: 378 GSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGG 437
RV T V YDP WT V MR+ R+ + L AVGG G
Sbjct: 365 ----------LRVRT--VDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD-GS 411
Query: 438 EVLASVEMYDLRRDRWTAAGAL-PRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDL 496
L+SVE Y+++ + W + R G VG G++Y GG G S++ +
Sbjct: 412 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG--GLLYAVGGYDGASRQCLSTV-EC 468
Query: 497 YVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPF--SEIERYDPGADQWTRL 554
Y E W+ A M T R G + VL ++A G P +E YDP + W ++
Sbjct: 469 YNATTNE--WTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 526
Query: 555 RPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
+ R G+ V ++GG D +V Y+ D+W
Sbjct: 527 ADMNMCRRNAGVCAVNGLLYVVGG----DDGSCNLASVEYYNPTTDKW 570
Score = 53.1 bits (126), Expect = 8e-07
Identities = 38/133 (28%), Positives = 54/133 (40%), Gaps = 13/133 (9%)
Query: 336 VVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQV 395
V ++ + W + ++ T G V N L+ +GG D +V V
Sbjct: 466 VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH------------DGPLVRKSV 513
Query: 396 HRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTA 455
YDP +AW +V M R + AV L VGG G LASVE Y+ D+WT
Sbjct: 514 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTV 572
Query: 456 AGALPRALHGHAG 468
+ +AG
Sbjct: 573 VSSCMSTGRSYAG 585
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 164 bits (415), Expect = 2e-40
Identities = 154/589 (26%), Positives = 239/589 (40%), Gaps = 68/589 (11%)
Query: 22 LRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQ 81
LR LCDV L + AHR +L+ S YFRA+F ESR + + ++
Sbjct: 61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAME 120
Query: 82 RLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARF 141
L+DF YT+ +++ V+ L AA LQ+ E C +L+RQL P NC A
Sbjct: 121 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH 180
Query: 142 GLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLAL 201
L A++ + QE++ + L L ++ + ++ E ++ +
Sbjct: 181 SCRELLRIADKFTQHNFQEVME----SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
Query: 202 AWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPARVKGLIIQALNYHT 260
AW++ ER ++L+ VR L+ P ++ V S + + L+ +A NY
Sbjct: 237 AWVKYS-IQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLL 295
Query: 261 TPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEE 320
P +PLMQG +T R P R EV+ A G +
Sbjct: 296 LPQERPLMQGPRTRPRKP---------IRCGEVLF--------AVGGWCSG--------- 329
Query: 321 LEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSA 380
+ +V +D + WR + + G V + L+ +GG S
Sbjct: 330 ----------DAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
Query: 381 SSPLADDSRVVTAQVHRYDPRFHAW-TEVPAMREARAHFWCGAVGERLLAVGGLGAGGEV 439
+S V RYDP+ + W ++V R +G L AVGG G
Sbjct: 380 NS------------VERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQD-GVSC 426
Query: 440 LASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVL 499
L VE YD + ++WT ++ G A AV G +Y G G G S L +
Sbjct: 427 LNIVERYDPKENKWTRVASMSTRRLGVAVAVLG-GFLYAVG-----GSDGTSPLNTVERY 480
Query: 500 GPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYE--PFSEIERYDPGADQWTRLRPL 557
P+E W APMGT R AV + ++A GR + S ERY+P +QW+ + +
Sbjct: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAM 540
Query: 558 PYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIG 606
R GLAVV + +GG + + +D D + W G
Sbjct: 541 TSRRSGVGLAVVNGQLMAVGGF----DGTTYLKTIEVFDPDANTWRLYG 585
Score = 89.4 bits (220), Expect = 1e-17
Identities = 78/270 (28%), Positives = 119/270 (44%), Gaps = 28/270 (10%)
Query: 365 GNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVG 424
G LF +GG + SS V RYDP+ + W V +M + R +
Sbjct: 317 GEVLFAVGGWCSGDAISS------------VERYDPQTNEWRMVASMSKRRCGVGVSVLD 364
Query: 425 ERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAG 484
+ L AVGG G L SVE YD + ++W++ A G G +Y GG
Sbjct: 365 DLLYAVGGHD-GSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGG--- 420
Query: 485 RGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGR--YEPFSEIE 542
+ G S L + P+E W++ A M T R G +AVL G ++A G P + +E
Sbjct: 421 --QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVE 478
Query: 543 RYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
RY+P ++W + P+ R G AV ++ +GG RD + Y+ ++W
Sbjct: 479 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG---RDD-TTELSSAERYNPRTNQW 534
Query: 603 EDIGCALPWAWSGLRCAVLQ---LAEGGDD 629
+ A+ SG+ AV+ +A GG D
Sbjct: 535 SPV-VAMTSRRSGVGLAVVNGQLMAVGGFD 563
Score = 66.6 bits (161), Expect = 7e-11
Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 19/190 (10%)
Query: 336 VVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQV 395
V +D ++W + + T LG +V G FL+ +GG +SPL V
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG----SDGTSPL--------NTV 477
Query: 396 HRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTA 455
RY+P+ + W + M R H C + + AVGG E L+S E Y+ R ++W+
Sbjct: 478 ERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSP 536
Query: 456 AGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTA 515
A+ G AV + ++ + G G + L+ + V P+ W M
Sbjct: 537 VVAMTSRRSGVGLAVVNGQLMAVG------GFDGTTYLKTIEVFDPDANTWRLYGGMNYR 590
Query: 516 RFGHHMAVLR 525
R G + V++
Sbjct: 591 RLGGGVGVIK 600
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 160 bits (406), Expect = 3e-39
Identities = 151/598 (25%), Positives = 231/598 (38%), Gaps = 63/598 (10%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H LL G LR LCD+ L + AH+ +LA S YF+A+F + E +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
LQ ++++ YT + +S DTVE L AA+ LQ+ L C +LE QL P N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
C + A +G AA + I + + + EL L ++ +
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAV----CQTEEFFELTHADLDEIVSNDCLNV 192
Query: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARV-K 249
E + +W++ + ER + +LL VR L+ L R+Y + L+ R K
Sbjct: 193 ATEETVFYALESWIKYD-VQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
Query: 250 GLIIQALNYHTTPSRQPLMQGE-QTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308
L+ +AL YH P + Q T R + VGG+ ++ V +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSV---------E 302
Query: 309 VAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFL 368
+ P+ N W L L P +C +
Sbjct: 303 MYFPQ-----------------------------NDSWIGLAPLNIPRYEFGICVLDQKV 333
Query: 369 FVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLL 428
+V+GG + + + R V ++P + WT + M E+R+ + L
Sbjct: 334 YVIGGIATNVRPGVTI----RKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELY 389
Query: 429 AVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEG 488
A+GG G L SVE Y + +W + A AV D G++Y GG
Sbjct: 390 ALGGYD-GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLD-GMIYAIGGY------ 441
Query: 489 GASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGR--YEPFSEIERYDP 546
G + + + P + W A M R + V+ G +F G S IERYDP
Sbjct: 442 GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDP 501
Query: 547 GADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWED 604
+QWT RP+ R G AV++ ++GG S V YD D W D
Sbjct: 502 HQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG----HSGSSYLNTVQKYDPISDTWLD 555
Score = 34.7 bits (78), Expect = 0.28
Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 12/84 (14%)
Query: 335 NVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQ 394
++ +D + ++W + P G N+L+V+GG S S ++
Sbjct: 495 SIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNT------------ 542
Query: 395 VHRYDPRFHAWTEVPAMREARAHF 418
V +YDP W + M R +F
Sbjct: 543 VQKYDPISDTWLDSAGMIYCRCNF 566
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 157 bits (396), Expect = 4e-38
Identities = 141/588 (23%), Positives = 225/588 (38%), Gaps = 80/588 (13%)
Query: 28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
LCDV L PAHR +L+ SDYF A+F + E++ + + L L+ +
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
Query: 88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTL 147
YT L L DT+E L AA LQ+T+ + +C +L +QL P NC + G L
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
Query: 148 DAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQE 207
+ A + + H E++ L L + +L + D+ E + + W+ +
Sbjct: 301 NVAHKYTMEHFIEVIKN----QEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHD 356
Query: 208 PTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPL 267
R LL +R L+P +L + + S + L+++A+ YH P R+ +
Sbjct: 357 -VQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSM 415
Query: 268 MQGEQTSIR-SPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEE 326
MQ +T R S + VGG A +
Sbjct: 416 MQSPRTKPRKSTVGALYAVGGMDAMKG--------------------------------- 442
Query: 327 EEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLAD 386
T + +D+ + W + + L V N L+V+GG
Sbjct: 443 ------TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR------------ 484
Query: 387 DSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMY 446
D V ++P WT +P M R + + AVGG G L +VE +
Sbjct: 485 DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERW 543
Query: 447 DLRRDRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQ 504
D +W A+ + PR+ G V +Y GG+ G+S L+ + P
Sbjct: 544 DPEGRQWNYVASMSTPRST---VGVVALNNKLYAIGGR-----DGSSCLKSMEYFDPHTN 595
Query: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRP 556
WS APM R G +A G ++ G P S +ERYDP D W+ + P
Sbjct: 596 KWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP 655
Query: 557 LPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWED 604
L R + + + ++GG V YD + W++
Sbjct: 656 LSVPRDAVAVCPLGDKLYVVGGY----DGHTYLNTVESYDAQRNEWKE 699
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 157 bits (396), Expect = 4e-38
Identities = 141/588 (23%), Positives = 225/588 (38%), Gaps = 80/588 (13%)
Query: 28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
LCDV L PAHR +L+ SDYF A+F + E++ + + L L+ +
Sbjct: 181 LCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYA 240
Query: 88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTL 147
YT L L DT+E L AA LQ+T+ + +C +L +QL P NC + G L
Sbjct: 241 YTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELL 300
Query: 148 DAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQE 207
+ A + + H E++ L L + +L + D+ E + + W+ +
Sbjct: 301 NVAHKYTMEHFIEVIKN----QEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHD 356
Query: 208 PTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPL 267
R LL +R L+P +L + + S + L+++A+ YH P R+ +
Sbjct: 357 -VQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSM 415
Query: 268 MQGEQTSIR-SPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEE 326
MQ +T R S + VGG A +
Sbjct: 416 MQSPRTKPRKSTVGALYAVGGMDAMKG--------------------------------- 442
Query: 327 EEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLAD 386
T + +D+ + W + + L V N L+V+GG
Sbjct: 443 ------TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR------------ 484
Query: 387 DSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMY 446
D V ++P WT +P M R + + AVGG G L +VE +
Sbjct: 485 DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG-HDGWSYLNTVERW 543
Query: 447 DLRRDRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQ 504
D +W A+ + PR+ G V +Y GG+ G+S L+ + P
Sbjct: 544 DPEGRQWNYVASMSTPRST---VGVVALNNKLYAIGGR-----DGSSCLKSMEYFDPHTN 595
Query: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRP 556
WS APM R G +A G ++ G P S +ERYDP D W+ + P
Sbjct: 596 KWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP 655
Query: 557 LPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWED 604
L R + + + ++GG V YD + W++
Sbjct: 656 LSVPRDAVAVCPLGDKLYVVGGY----DGHTYLNTVESYDAQRNEWKE 699
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 156 bits (395), Expect = 5e-38
Identities = 145/583 (24%), Positives = 229/583 (39%), Gaps = 74/583 (12%)
Query: 28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
LCDV L + PAHR +L+ SDYF A+F S E++ I + L L+ F
Sbjct: 211 LCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFA 270
Query: 88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTL 147
YT L L DT+E+ L AA LQ+ + + +C +L + L P NC A G +
Sbjct: 271 YTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELM 330
Query: 148 DAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEARLLGLALAWLRQE 207
A + ++ E++ L L L +L + DV E + + W++ +
Sbjct: 331 KVAHSYTMENIMEVIRN----QEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYD 386
Query: 208 PTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPL 267
R + LL +R L+P +L + + + + LI++A+ YH P R+ L
Sbjct: 387 -MQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTL 445
Query: 268 MQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEE 327
MQ SP+T+ P+++ G + A + + E+
Sbjct: 446 MQ-------SPRTK-------------------PRKSTVGTLYAVGGMDNNKGATTIEK- 478
Query: 328 EEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADD 387
+D+ + W + L V + LFV+GG D
Sbjct: 479 -----------YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR------------D 515
Query: 388 SRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYD 447
V Y+P+ WT +P M R + + AVGG G L +VE +D
Sbjct: 516 GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGG-HDGWSYLNTVERWD 574
Query: 448 LRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWS 507
+ +WT ++ A G G +Y GG+ G+S L + P W+
Sbjct: 575 PQSQQWTFVASMSIA-RSTVGVAALNGKLYSVGGR-----DGSSCLSSMEYYDPHTNKWN 628
Query: 508 KKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRPLPY 559
APM R G +A G ++A G P S +ERYDP D WT + PL
Sbjct: 629 MCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSM 688
Query: 560 DRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRW 602
R G+ ++ + +GG Q + YD + W
Sbjct: 689 PRDAVGVCLLGDRLYAVGGY----DGQTYLNTMESYDPQTNEW 727
Score = 46.2 bits (108), Expect = 9e-05
Identities = 49/203 (24%), Positives = 75/203 (36%), Gaps = 27/203 (13%)
Query: 330 WELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSR 389
W V +D + +W + + V L+ +GG S SS
Sbjct: 564 WSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSS------- 616
Query: 390 VVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAG-----GEVLASVE 444
+ YDP + W M + R L AVGG A +L VE
Sbjct: 617 -----MEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVE 671
Query: 445 MYDLRRDRWT--AAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPE 502
YD + D WT A ++PR G +GDR +Y GG G+ + L + P+
Sbjct: 672 RYDPKTDTWTMVAPLSMPRDAVG-VCLLGDR--LYAVGGYDGQ-----TYLNTMESYDPQ 723
Query: 503 EQVWSKKAPMGTARFGHHMAVLR 525
W++ A + R G + V++
Sbjct: 724 TNEWTQMASLNIGRAGACVVVIK 746
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 154 bits (390), Expect = 2e-37
Identities = 177/622 (28%), Positives = 250/622 (40%), Gaps = 99/622 (15%)
Query: 10 AHGGALLTGYQALRAEGFLCDVTLETEGS-EFPAHRSLLACSSDYFRALFKSHTQESRAR 68
AH +LL G LRAE DVTLE G +FPAHR++LA +S YFRA+F +ESRA
Sbjct: 16 AHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAE 75
Query: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
+ LH LQ LLDF YT +++S D E L AA LQ CG +L++QL
Sbjct: 76 RVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDL 135
Query: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
NC + A F + AA+R I+ H+ EL G L L L L +
Sbjct: 136 ANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-----GAEQLERLPLARLLRYLRDDGL 190
Query: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARV 248
E LAL W+R +P R AH +LLE VR V RR Y L A V
Sbjct: 191 CVPKEEAAYQLALRWVRADP-PRRAAHWPQLLEAVRLPFV-----RRFY------LLAHV 238
Query: 249 KGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308
+ +PL+ R P LL R AR+ + A R RG
Sbjct: 239 EA--------------EPLV------ARCPPCLRLL---REARDF---QAARYDRHDRGP 272
Query: 309 VAAPEPEEEEEELE--------EEEEEEEWELTQNVVAFDVYN---HRWRSLTQLPTPL- 356
P E +++ +E +V D YN +WR L + P L
Sbjct: 273 CPRMRPRPSTGLAEILVLVGGCDQDCDE-------LVTVDCYNPQTGQWRYLAEFPDHLG 325
Query: 357 LGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARA 416
G+S+ GN ++V GG +D SR+ V RY+ + W EV M +AR
Sbjct: 326 GGYSIVALGNDIYVTGG-----------SDGSRLYDC-VWRYNSSVNEWAEVAPMLKARE 373
Query: 417 HFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVV 476
+ + L V S E YD D W A + + + RG +
Sbjct: 374 YHSSSVLDGLLYVVAA--------DSTERYDHTTDSWEALQPMTYPM-DNCSTTACRGRL 424
Query: 477 YISGGKAGRGEGGASSLRDLYVLGPEEQVWS--KKAPMGTARFGHHMAVLRGAVFAFLGR 534
Y G AG+ + P+ +WS + F A L G ++
Sbjct: 425 YAIGSLAGK------ETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--- 475
Query: 535 YEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVG 594
+ +E++ Y+P ++W ++ + LAV+ + GG D+ + V
Sbjct: 476 RDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGY---DNTFELSDVVEA 532
Query: 595 YDLDLDRWEDIG-CALPWAWSG 615
YD + W +G P W G
Sbjct: 533 YDPETRAWSVVGRLPEPTFWHG 554
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 2/104 (1%)
Query: 392 TAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRD 451
+A+V Y+P + W ++P+M + +G +L GG E+ VE YD
Sbjct: 479 SAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETR 538
Query: 452 RWTAAGALPRAL--HGHAGAVGDRGVVYISGGKAGRGEGGASSL 493
W+ G LP HG SGG+ + G+ +
Sbjct: 539 AWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDM 582
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 154 bits (388), Expect = 3e-37
Identities = 145/577 (25%), Positives = 223/577 (38%), Gaps = 40/577 (6%)
Query: 9 KAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRAR 68
K H +R G LCD+ L E AH+ +LA S YF A+F + ESR
Sbjct: 72 KRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQT 131
Query: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
+ LH L +L+ F YTA + + V+ L AAS LQ+ C ++L QL P
Sbjct: 132 HVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 191
Query: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
NC A + L AA R ++ H ++ L P L + D
Sbjct: 192 SNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDV-----AKTEEFMLLPLKQVLELVSSDS 246
Query: 189 ARVP-EARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVL-PA 246
VP E + L+W++ + R H L++ VR L+ D L LV
Sbjct: 247 LNVPSEEEVYRAVLSWVKHDVDARR-QHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHP 305
Query: 247 RVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTR---ILLVGGRRAREVVIEEVAAPQR 303
K L+I+AL +H P ++ ++ +T R + + VGG + + A R
Sbjct: 306 DCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTR 365
Query: 304 AARGQVAAPEPEEEE--------EELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTP 355
R V A L + V ++D + W+ + T
Sbjct: 366 TDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTR 425
Query: 356 LLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREAR 415
V L+ GG + +S RYDP WT V AM R
Sbjct: 426 RSCLGVAALHGLLYSAGGYDGASCLNS------------AERYDPLTGTWTSVAAMSTRR 473
Query: 416 AHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGV 475
+ + L AVGG + LA+VE Y+ + + W+ ++ + AG G
Sbjct: 474 RYVRVATLDGNLYAVGGYDSSSH-LATVEKYEPQVNVWSPVASM-LSRRSSAGVAVLEGA 531
Query: 476 VYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGR- 534
+Y++G G G S L + P+ W APM R H + + G ++A G
Sbjct: 532 LYVAG-----GNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGND 586
Query: 535 -YEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVE 570
+ IE+Y+P ++W + R G+AV+E
Sbjct: 587 GSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/218 (29%), Positives = 91/218 (41%), Gaps = 23/218 (10%)
Query: 364 AGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
AG LF +GG S + YD R W V +M RA AV
Sbjct: 340 AGPVLFAVGGGSLFA------------IHGDCEAYDTRTDRWHVVASMSTRRARVGVAAV 387
Query: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
G RL AVGG G LA+VE YD + W ++ G G++Y +G
Sbjct: 388 GNRLYAVGGYD-GTSDLATVESYDPVTNTWQPEVSM-GTRRSCLGVAALHGLLYSAG--- 442
Query: 484 GRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--- 540
G GAS L P W+ A M T R +A L G ++A +G Y+ S
Sbjct: 443 --GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYA-VGGYDSSSHLAT 499
Query: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGG 578
+E+Y+P + W+ + + R G+AV+E + GG
Sbjct: 500 VEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGG 537
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 152 bits (384), Expect = 9e-37
Identities = 144/589 (24%), Positives = 231/589 (39%), Gaps = 80/589 (13%)
Query: 28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
LCDV L PAHR +L+ SDYF A+F + +E+R I + L L+ +
Sbjct: 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 232
Query: 88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTL 147
YT L L D +E L A LQ+++ + C ++L +QL P NC + A G
Sbjct: 233 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLH 292
Query: 148 DAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVP-EARLLGLALAWLRQ 206
A + H E++ L P S A L A D +P E +L L W+R
Sbjct: 293 KVAHNYTMEHFMEVIRNQE-----FVLLPASEIAKLLASDDMNIPNEETILNALLTWVRH 347
Query: 207 EPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQP 266
+ +R ++LL +R L+ L + + + LI++A+ YH P R+P
Sbjct: 348 D-LEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRP 406
Query: 267 LMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEE 326
++Q SP+T+ P+++ G + A + + E+
Sbjct: 407 MLQ-------SPRTK-------------------PRKSTVGTLFAVGGMDSTKGATSIEK 440
Query: 327 EEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLAD 386
+D+ + W + + L V + L+V+GG
Sbjct: 441 ------------YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR------------ 476
Query: 387 DSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMY 446
D V Y+P+ W+ +P M R + + AVGG G L +VE +
Sbjct: 477 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERW 535
Query: 447 DLRRDRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQ 504
D + +W A + PR+ G A G +Y GG+ G+S L+ + P
Sbjct: 536 DPQARQWNFVATMSTPRSTVGVAVL---SGKLYAVGGR-----DGSSCLKSVECFDPHTN 587
Query: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRP 556
W+ A M R G + G ++A G P S +ERYDP D WT +
Sbjct: 588 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 647
Query: 557 LPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
+ R G+ ++ + +GG Q V YD + W +
Sbjct: 648 MSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEWTQV 692
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/137 (32%), Positives = 67/137 (48%), Gaps = 12/137 (8%)
Query: 334 QNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGG-ESPSGSASSPLADDSRVVT 392
++V FD + ++W Q+ G V T L+ +GG ++P+ + +S L+D
Sbjct: 577 KSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC----- 631
Query: 393 AQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDR 452
V RYDP+ WT V +M +R +G++L AVGG G L +VE YD + +
Sbjct: 632 --VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNE 688
Query: 453 WTAAGALPRALHGHAGA 469
WT L G AGA
Sbjct: 689 WTQVAPL---CLGRAGA 702
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/196 (25%), Positives = 71/196 (36%), Gaps = 27/196 (13%)
Query: 330 WELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSR 389
W V +D +W + + TP V L+ +GG S S
Sbjct: 526 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS------- 578
Query: 390 VVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLAS-----VE 444
V +DP + WT M + R L A+GG A L S VE
Sbjct: 579 -----VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 633
Query: 445 MYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGK--AGRGEGGASSLRDLYVLGPE 502
YD + D WTA ++ + AVG V + G K A G G + L + P+
Sbjct: 634 RYDPKTDMWTAVASMSIS----RDAVG----VCLLGDKLYAVGGYDGQAYLNTVEAYDPQ 685
Query: 503 EQVWSKKAPMGTARFG 518
W++ AP+ R G
Sbjct: 686 TNEWTQVAPLCLGRAG 701
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 152 bits (384), Expect = 9e-37
Identities = 144/589 (24%), Positives = 231/589 (39%), Gaps = 80/589 (13%)
Query: 28 LCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFI 87
LCDV L PAHR +L+ SDYF A+F + +E+R I + L L+ +
Sbjct: 219 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 278
Query: 88 YTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTL 147
YT L L D +E L A LQ+++ + C ++L +QL P NC + A G
Sbjct: 279 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLH 338
Query: 148 DAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVP-EARLLGLALAWLRQ 206
A + H E++ L P S A L A D +P E +L L W+R
Sbjct: 339 KVAHNYTMEHFMEVIRNQE-----FVLLPASEIAKLLASDDMNIPNEETILNALLTWVRH 393
Query: 207 EPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQP 266
+ +R ++LL +R L+ L + + + LI++A+ YH P R+P
Sbjct: 394 D-LEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRP 452
Query: 267 LMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEE 326
++Q SP+T+ P+++ G + A + + E+
Sbjct: 453 MLQ-------SPRTK-------------------PRKSTVGTLFAVGGMDSTKGATSIEK 486
Query: 327 EEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLAD 386
+D+ + W + + L V + L+V+GG
Sbjct: 487 ------------YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR------------ 522
Query: 387 DSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMY 446
D V Y+P+ W+ +P M R + + AVGG G L +VE +
Sbjct: 523 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERW 581
Query: 447 DLRRDRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQ 504
D + +W A + PR+ G A G +Y GG+ G+S L+ + P
Sbjct: 582 DPQARQWNFVATMSTPRSTVGVAVL---SGKLYAVGGR-----DGSSCLKSVECFDPHTN 633
Query: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRP 556
W+ A M R G + G ++A G P S +ERYDP D WT +
Sbjct: 634 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 693
Query: 557 LPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
+ R G+ ++ + +GG Q V YD + W +
Sbjct: 694 MSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEWTQV 738
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/137 (32%), Positives = 67/137 (48%), Gaps = 12/137 (8%)
Query: 334 QNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGG-ESPSGSASSPLADDSRVVT 392
++V FD + ++W Q+ G V T L+ +GG ++P+ + +S L+D
Sbjct: 623 KSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC----- 677
Query: 393 AQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDR 452
V RYDP+ WT V +M +R +G++L AVGG G L +VE YD + +
Sbjct: 678 --VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNE 734
Query: 453 WTAAGALPRALHGHAGA 469
WT L G AGA
Sbjct: 735 WTQVAPL---CLGRAGA 748
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/196 (25%), Positives = 71/196 (36%), Gaps = 27/196 (13%)
Query: 330 WELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSR 389
W V +D +W + + TP V L+ +GG S S
Sbjct: 572 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS------- 624
Query: 390 VVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLAS-----VE 444
V +DP + WT M + R L A+GG A L S VE
Sbjct: 625 -----VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 679
Query: 445 MYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGK--AGRGEGGASSLRDLYVLGPE 502
YD + D WTA ++ + AVG V + G K A G G + L + P+
Sbjct: 680 RYDPKTDMWTAVASMSIS----RDAVG----VCLLGDKLYAVGGYDGQAYLNTVEAYDPQ 731
Query: 503 EQVWSKKAPMGTARFG 518
W++ AP+ R G
Sbjct: 732 TNEWTQVAPLCLGRAG 747
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 151 bits (381), Expect = 2e-36
Identities = 148/604 (24%), Positives = 247/604 (40%), Gaps = 60/604 (9%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H +L +R CDV L+ F AHR +LA SS YF ALF +ES V+
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
+ A Q LLDFIYT +++ ++ V++ + AA LQ+TE + LC +L+ Q+ P N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
C + + L+ +E I H E+ L L L +L + +++
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEV----HSGEEFLALTKDQLIKILRSEELSI 194
Query: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSG-SGLVLPARVK 249
E ++ A+ W+ ++ +R H E+L+ +RF L+P L + G S L ++
Sbjct: 195 EDEYQVFLAAMQWILKD-LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQ 253
Query: 250 GLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQV 309
L+ + +P QTS P+ ++AR+ + V R G+
Sbjct: 254 TLLKEYCEVCKSPKENKFCSFLQTSKVRPR--------KKARK-YLYAVGGYTRLQGGRW 304
Query: 310 AAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLF 369
+ + V FD ++ W +++ L G V G ++
Sbjct: 305 S------------------DSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVY 346
Query: 370 VLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLA 429
+GGE S ++ YDP WT V +M R + A
Sbjct: 347 AIGGEKDS------------MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYA 394
Query: 430 VGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGG 489
+GG G E+ ++E +D ++W G + + + + G +G++Y+ GG + G
Sbjct: 395 LGG-WVGAEIGNTIERFDPDENKWEVVGNMAVSRY-YFGCCEMQGLIYVIGGISNEG--- 449
Query: 490 ASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLG---RYEPFSEIERYDP 546
LR V P + WS PMGT R +A L +++ G + +E+Y
Sbjct: 450 -IELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 547 GADQWTRLRPLPYDRFCYGLAVVEETALLL--GGLKWRDSRQVP--TRNVVGYDLDLDRW 602
++W + + R G+ VV LL GG P +V Y+ D W
Sbjct: 509 EEEKWVEVASMKVPR--AGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
Query: 603 EDIG 606
+IG
Sbjct: 567 TEIG 570
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/197 (24%), Positives = 83/197 (42%), Gaps = 17/197 (8%)
Query: 331 ELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRV 390
E+ + FD ++W + + C ++V+GG S G +
Sbjct: 402 EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG-----------I 450
Query: 391 VTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRR 450
YDP W+ +P M RA+ A+ + + +VGG + L +VE Y
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEE 510
Query: 451 DRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGA-SSLRDLYVLGPEEQVWS 507
++W A+ +PRA V G++Y+SGG++ + A +L + V P W+
Sbjct: 511 EKWVEVASMKVPRA---GMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWT 567
Query: 508 KKAPMGTARFGHHMAVL 524
+ M T+R +AVL
Sbjct: 568 EIGNMITSRCEGGVAVL 584
Score = 36.2 bits (82), Expect = 0.096
Identities = 25/90 (27%), Positives = 35/90 (38%), Gaps = 10/90 (11%)
Query: 330 WELTQN----VVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLA 385
W TQ+ V + +W + + P G V L+V GG S S +P
Sbjct: 493 WNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGT 552
Query: 386 DDSRVVTAQVHRYDPRFHAWTEVPAMREAR 415
DS V Y+P WTE+ M +R
Sbjct: 553 LDS------VEVYNPHSDTWTEIGNMITSR 576
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 149 bits (376), Expect = 8e-36
Identities = 143/599 (23%), Positives = 245/599 (40%), Gaps = 56/599 (9%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H +L +R CDV L+ F AHR +LA SS YF ALF +ES V+
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
+ A Q LLDFIYT +++ ++ V++ + AA LQ+TE + LC +L+ Q+ P N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
C + + L+ +E I H E+ L L L +L + +++
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEV----HSGEEFLALTKDQLIKILRSEELSI 194
Query: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSG-SGLVLPARVK 249
E ++ A+ W+ ++ +R H E+L+ +RF L+P L + G S L ++
Sbjct: 195 EDEYQVFLAAMQWILKD-LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQ 253
Query: 250 GLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQV 309
L+ + +P QTS P+ ++AR+ + V R G+
Sbjct: 254 TLLKEYCEVCKSPKENKFCSFLQTSKVRPR--------KKARK-YLYAVGGYTRLQGGRW 304
Query: 310 AAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLF 369
+ + V FD ++ W +++ L G V G ++
Sbjct: 305 S------------------DSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVY 346
Query: 370 VLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLA 429
+GGE S ++ YDP WT V +M R + A
Sbjct: 347 AIGGEKDS------------MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYA 394
Query: 430 VGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGG 489
+GG G E+ ++E +D ++W G + + + + G +G++Y+ GG + G
Sbjct: 395 LGG-WVGAEIGNTIERFDPDENKWEVVGNMAVSRY-YFGCCEMQGLIYVIGGISNEG--- 449
Query: 490 ASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLG---RYEPFSEIERYDP 546
LR V P + WS PMGT R +A L +++ G + +E+Y
Sbjct: 450 -IELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 547 GADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
++W + + R G+ VV LL S + Y++ +WE++
Sbjct: 509 EEEKWVEVASMKVPR--AGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKWENM 565
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 148 bits (373), Expect = 2e-35
Identities = 145/603 (24%), Positives = 239/603 (39%), Gaps = 79/603 (13%)
Query: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
H ++L +LR LCDVTL E +FPAHR +LA SDYF A+F S E +
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
+ +A+ ++ LLDF+YT + ++++ V++ L AA LQ+ C +LE QL P N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
C + A + AAE H E++ + L+ + ++ ++
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQH----EEFILLSQGEVEKLIKCDEIQV 190
Query: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLV-LPARVK 249
E + + W++ ER LL+ VR L+ + V + + +
Sbjct: 191 DSEEPVFEAVINWVK-HAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 250 GLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILL-VGGRRAREVVIEEVAAPQRAARGQ 308
L+ +A +H P + MQG +T R +LL VGG +++ I+ V
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE--------- 300
Query: 309 VAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFL 368
+ + + +EW ++ R+ + L + +
Sbjct: 301 -------------KYDPKTQEWSFLPSITR----KRRYVASVSL------------HDRI 331
Query: 369 FVLGGESPSGSASSP-----LADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
+V+GG SS AD+ V W V M R +
Sbjct: 332 YVIGGYDGRSRLSSVECLDYTADEDGV--------------WYSVAPMNVRRGLAGATTL 377
Query: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
G+ + GG G S+E YD D+W+ G + A G AG V GV+Y G
Sbjct: 378 GDMIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREG-AGLVVASGVIYCLG--- 432
Query: 484 GRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYE---PFSE 540
G G + L + P W+ PM T R G +A+L ++ +G ++ S
Sbjct: 433 --GYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYV-VGGFDGTAHLSS 489
Query: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
+E Y+ D WT + + R G V+ + G D + ++ YD +D
Sbjct: 490 VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGY---DGNSL-LSSIECYDPIID 545
Query: 601 RWE 603
WE
Sbjct: 546 SWE 548
Score = 79.3 bits (194), Expect = 1e-14
Identities = 66/248 (26%), Positives = 106/248 (42%), Gaps = 29/248 (11%)
Query: 364 AGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
A L V+GG GS SP+ V +YDP+ W+ +P++ R + ++
Sbjct: 279 ANEVLLVVGG---FGSQQSPID--------VVEKYDPKTQEWSFLPSITRKRRYVASVSL 327
Query: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDR---WTAAGALPRALHGHAGAVGDRGVVYISG 480
+R+ +GG G L+SVE D D W + + G AGA ++Y+SG
Sbjct: 328 HDRIYVIGGYD-GRSRLSSVECLDYTADEDGVWYSVAPM-NVRRGLAGATTLGDMIYVSG 385
Query: 481 GKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFS- 539
G G + D P WS M TAR G + V G ++ LG Y+ +
Sbjct: 386 GFDGSRRHTSMERYD-----PNIDQWSMLGDMQTAREGAGLVVASGVIYC-LGGYDGLNI 439
Query: 540 --EIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDL 597
+E+YDP WT + P+ R G+A++ + ++GG +V Y++
Sbjct: 440 LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF----DGTAHLSSVEAYNI 495
Query: 598 DLDRWEDI 605
D W +
Sbjct: 496 RTDSWTTV 503
Score = 64.3 bits (155), Expect = 3e-10
Identities = 61/209 (29%), Positives = 88/209 (42%), Gaps = 13/209 (6%)
Query: 401 RFHAWTEVPA-MREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGAL 459
+FH E+ + M+ R GA E LL VGG G+ + VE YD + W+ ++
Sbjct: 257 KFHLRPELRSQMQGPRTRARLGA-NEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSI 315
Query: 460 PRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGH 519
R + +V +Y+ GG GR SS+ L E+ VW APM R G
Sbjct: 316 TRKRR-YVASVSLHDRIYVIGGYDGRSR--LSSVECLDYTADEDGVWYSVAPMNVRR-GL 371
Query: 520 HMAVLRGAVFAFLGRYEP---FSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLL 576
A G + G ++ + +ERYDP DQW+ L + R GL V L
Sbjct: 372 AGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCL 431
Query: 577 GGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
GG D + +V YD W ++
Sbjct: 432 GGY---DGLNI-LNSVEKYDPHTGHWTNV 456
Score = 60.1 bits (144), Expect = 6e-09
Identities = 53/189 (28%), Positives = 74/189 (39%), Gaps = 23/189 (12%)
Query: 339 FDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRY 398
+D +W L + T G + A ++ LGG D + V +Y
Sbjct: 399 YDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY------------DGLNILNSVEKY 446
Query: 399 DPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGA 458
DP WT V M R+ + + + VGG G L+SVE Y++R D WT +
Sbjct: 447 DPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTS 505
Query: 459 L--PRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTAR 516
+ PR + GA RG +Y A G G S L + P W MGT R
Sbjct: 506 MTTPRC---YVGATVLRGRLY-----AIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQR 557
Query: 517 FGHHMAVLR 525
+ VLR
Sbjct: 558 CDAGVCVLR 566
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 147 bits (372), Expect = 2e-35
Identities = 141/601 (23%), Positives = 237/601 (39%), Gaps = 77/601 (12%)
Query: 13 GALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHL 72
G+LL Y+ G LCDVTL+ H+ +LAC YFRA+F S E++ +I +
Sbjct: 55 GSLLRFYE----NGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEI 110
Query: 73 HVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCC 132
++ L+ F+Y++ L+L++D V+ L AA LQV C Y++ P NC
Sbjct: 111 RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCL 170
Query: 133 FAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVP 192
A +D A++ H E++ + ++P L +L + D+
Sbjct: 171 AVRAFAESHNRIDLMDMADQYACDHFTEVVEC----EDFVSVSPQHLHKLLSSSDLNIEN 226
Query: 193 EARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLP-ARVKGL 251
E ++ A+ WL P E L +VR L+P D L V + +V + + L
Sbjct: 227 EKQVYNAAIKWLLANPQ-HHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDL 285
Query: 252 IIQALNYHTTPSRQPLMQGEQTSIRSPQTR----ILLVGGRRAREVVIEEVAAPQRAARG 307
+ +A NYH S + + E + +P+ + VGGR G
Sbjct: 286 LDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGR------------------G 327
Query: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
P +++ + + + W ++ + V +
Sbjct: 328 GSGDP--------------------FRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGK 367
Query: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
++ +GG D + +DP + W +M R ++G +
Sbjct: 368 VYAVGGH------------DGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPI 415
Query: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
A+GGL VE YD+ D+W+ + G G+V VY GG
Sbjct: 416 YAIGGLD-DNTCFNDVERYDIESDQWSTVAPM-NTPRGGVGSVALVNHVYAVGGN----- 468
Query: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYE--PFSEIERYD 545
G +SL + P W + MG R G+ ++ L G ++ G + P S +ERYD
Sbjct: 469 DGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYD 528
Query: 546 PGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
P +++W + L R G+A V +GG + V +D L+RWE +
Sbjct: 529 PRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG----HNGNAYLNTVEAFDPVLNRWELV 584
Query: 606 G 606
G
Sbjct: 585 G 585
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/189 (26%), Positives = 72/189 (38%), Gaps = 19/189 (10%)
Query: 335 NVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQ 394
+V +D+ + +W ++ + TP G N ++ +GG S SS
Sbjct: 429 DVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSS------------ 476
Query: 395 VHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWT 454
V RYDP W EV M + RA + L VGG L+SVE YD R ++W
Sbjct: 477 VERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSNKWD 535
Query: 455 AAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGT 514
AL G G G ++ G G G + L + P W +
Sbjct: 536 YVAALTTP-RGGVGIATVMGKIFAVG-----GHNGNAYLNTVEAFDPVLNRWELVGSVSH 589
Query: 515 ARFGHHMAV 523
R G +AV
Sbjct: 590 CRAGAGVAV 598
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 141 bits (356), Expect = 2e-33
Identities = 140/585 (23%), Positives = 236/585 (40%), Gaps = 55/585 (9%)
Query: 1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS 60
M+ L + +H +L LR DVTL FP HR++LA SS YF A+F
Sbjct: 18 MNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSH 77
Query: 61 HTQESRARVI----HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALG 116
+ESR + +LH P L+ LLDF Y++ ++++ + E LEA LQ +
Sbjct: 78 GLRESRDDTVNFQDNLH-PEV--LELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRD 134
Query: 117 LCGRYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNP 176
+LE+ L P NC ++ + + R + H + + L+
Sbjct: 135 AAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETV----RQSEDFNSLSK 190
Query: 177 TSLRAVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRV 236
+L ++ + ++ E + L W++ + R H ELL VR L+P+D L+
Sbjct: 191 DTLLDLISSDELETEDERVVFEAILQWVKHD-LEPRKVHLPELLRSVRLALLPSDCLQEA 249
Query: 237 YSGSGLVL-----------PARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLV 285
S L++ R K I+Q T+P +P G +L++
Sbjct: 250 VSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGH---------TLLIL 300
Query: 286 GGRRAREVVIEEVAAPQRAARGQVAAPEPEEEE-------EELEEEEEEEEWELTQNVVA 338
GG+ I +V + + P P +E + E ++++V
Sbjct: 301 GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV 360
Query: 339 FDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRY 398
+D + W + GH N L+V+GG + S + V QV +Y
Sbjct: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHT---SLAGVFPASPSVSLKQVEKY 417
Query: 399 DPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGA 458
DP + W V +R+ ++ + +L GG ++++ V+ YD +RWT
Sbjct: 418 DPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE 477
Query: 459 LPRALHGHAGAV-GDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARF 517
P+ A AV G + ++I GG E A+S Y E W++ M R
Sbjct: 478 CPQPWRYTAAAVLGSQ--IFIMGGDT---EFTAAS---AYRFDCETNQWTRIGDMTAKRM 529
Query: 518 GHHMAVLRGAVFAFLGRY---EPFSEIERYDPGADQWTRLRPLPY 559
H A+ G +G Y + ++ YDP +D W + +PY
Sbjct: 530 SCH-ALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPY 573
Score = 55.8 bits (133), Expect = 1e-07
Identities = 52/249 (20%), Positives = 96/249 (38%), Gaps = 25/249 (10%)
Query: 364 AGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
AG+ L +LGG++ + ++++ D + + R F A+
Sbjct: 293 AGHTLLILGGQT--------------FMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAI 338
Query: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
G ++ GG G+ V V +YD + W+ A + A GH A + + + G +
Sbjct: 339 GCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTS 398
Query: 484 GRGEGGAS---SLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLG---RYEP 537
G AS SL+ + P W AP+ + + +F F G +
Sbjct: 399 LAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDM 458
Query: 538 FSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDL 597
S+++ YDP ++WT P AV+ ++GG + + +D
Sbjct: 459 VSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-----DTEFTAASAYRFDC 513
Query: 598 DLDRWEDIG 606
+ ++W IG
Sbjct: 514 ETNQWTRIG 522
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 139 bits (349), Expect = 1e-32
Identities = 141/588 (23%), Positives = 230/588 (39%), Gaps = 81/588 (13%)
Query: 30 DVTLETEG-SEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIY 88
D T E E S+ + R +L+ SDYF A+F + +E+R I + L L+ + Y
Sbjct: 159 DGTSEEENESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAY 218
Query: 89 TAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLD 148
T L L D +E L A LQ+++ + C ++L +QL P NC + A G
Sbjct: 219 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 278
Query: 149 AAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVP-EARLLGLALAWLRQE 207
A + H E++ L P S A L A D +P E +L L W+R +
Sbjct: 279 VAHNYTMEHFMEVIRNQE-----FVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 333
Query: 208 PTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQALNYHTTPSRQPL 267
+R ++LL +R L+ L + + + LI++A+ YH P R+P+
Sbjct: 334 -LEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPM 392
Query: 268 MQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEPEEEEEELEEEEEE 327
+Q SP+T+ P+++ G + A + + E+
Sbjct: 393 LQ-------SPRTK-------------------PRKSTVGTLFAVGGMDSTKGATSIEK- 425
Query: 328 EEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADD 387
+D+ + W + + L V + L+V+GG D
Sbjct: 426 -----------YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR------------D 462
Query: 388 SRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYD 447
V Y+P+ W+ +P M R + + AVGG G L +VE +D
Sbjct: 463 GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWD 521
Query: 448 LRRDRW--TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQV 505
+ +W A + PR+ G A G +Y GG+ G+S L+ + P
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVL---SGKLYAVGGR-----DGSSCLKSVECFDPHTNK 573
Query: 506 WSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSE--------IERYDPGADQWTRLRPL 557
W+ A M R G + G ++A G P S +ERYDP D WT + +
Sbjct: 574 WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM 633
Query: 558 PYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDI 605
R G+ ++ + +GG Q V YD + W +
Sbjct: 634 SISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEWTQV 677
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/137 (32%), Positives = 67/137 (48%), Gaps = 12/137 (8%)
Query: 334 QNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGG-ESPSGSASSPLADDSRVVT 392
++V FD + ++W Q+ G V T L+ +GG ++P+ + +S L+D
Sbjct: 562 KSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC----- 616
Query: 393 AQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDR 452
V RYDP+ WT V +M +R +G++L AVGG G L +VE YD + +
Sbjct: 617 --VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNE 673
Query: 453 WTAAGALPRALHGHAGA 469
WT L G AGA
Sbjct: 674 WTQVAPL---CLGRAGA 687
Score = 51.2 bits (121), Expect = 3e-06
Identities = 50/196 (25%), Positives = 71/196 (36%), Gaps = 27/196 (13%)
Query: 330 WELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSR 389
W V +D +W + + TP V L+ +GG S S
Sbjct: 511 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS------- 563
Query: 390 VVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLAS-----VE 444
V +DP + WT M + R L A+GG A L S VE
Sbjct: 564 -----VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 618
Query: 445 MYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGK--AGRGEGGASSLRDLYVLGPE 502
YD + D WTA ++ + AVG V + G K A G G + L + P+
Sbjct: 619 RYDPKTDMWTAVASMSIS----RDAVG----VCLLGDKLYAVGGYDGQAYLNTVEAYDPQ 670
Query: 503 EQVWSKKAPMGTARFG 518
W++ AP+ R G
Sbjct: 671 TNEWTQVAPLCLGRAG 686
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 138 bits (348), Expect = 1e-32
Identities = 134/577 (23%), Positives = 239/577 (41%), Gaps = 39/577 (6%)
Query: 1 MSYFLSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKS 60
++ +L + ++ ++LT LR + DV L FP HR++LA S YF A+F
Sbjct: 18 INIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSG 77
Query: 61 HTQESRARVIHL-HVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCG 119
+ES+ ++ + L+ LLD+ Y++ + ++ + E LEA L+ + C
Sbjct: 78 GLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACA 137
Query: 120 RYLERQLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSL 179
+LE+ L P NC ++ + + R +S+ Q + L+L +
Sbjct: 138 EFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKN----EDFLQLPQDMV 193
Query: 180 RAVLGAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSG 239
+L + ++ E + A+ W+ + +R + ELL+ VR L+PA L +
Sbjct: 194 VQLLSSEELETEDERLVYESAINWISYD-LKKRYCYLPELLQTVRLALLPAIYLMENVAM 252
Query: 240 SGLVLPARVKGLIIQALNYHTTPSRQPLMQ--GEQTSI----RSPQTRILLVGGR--RAR 291
L+ R I++ + ++Q G TS+ R + L+GG+
Sbjct: 253 EELITKQRKSKEIVE----EAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCD 308
Query: 292 EVVIEEVAAPQRAARGQVAAPEPEEEE-----EELEEEEEEEEWELTQNVVAFDVYNHRW 346
++ + + A + + + +P E + E ++++V +D + W
Sbjct: 309 KLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEW 368
Query: 347 RSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWT 406
+ GH + L+V+GG + +A+ L V QV YDP + WT
Sbjct: 369 SKAAPMLVARFGHGSAELKHCLYVVGGHT---AATGCLPASPSVSLKQVEHYDPTINKWT 425
Query: 407 EVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGH 466
V +RE ++ + +L A GG + L V+ YD +RWT P+
Sbjct: 426 MVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYT 485
Query: 467 AGAV-GDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLR 525
A AV G++ ++I GG E A S Y E W+K + R H AV
Sbjct: 486 AAAVLGNQ--IFIMGGDT---EFSACS---AYKFNSETYQWTKVGDVTAKRMSCH-AVAS 536
Query: 526 GAVFAFLGRY---EPFSEIERYDPGADQWTRLRPLPY 559
G +G Y + ++ YDP D W + +PY
Sbjct: 537 GNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPY 573
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 136 bits (343), Expect = 5e-32
Identities = 160/605 (26%), Positives = 234/605 (38%), Gaps = 76/605 (12%)
Query: 15 LLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHV 74
+L G Q LR++ L DVTL G E P HR LLA SS YF A+F ES + + L
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 75 PSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFA 134
A + +L+DF+YT L+++ VE A+ L +CGRYL++QL NC
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 135 ANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVARVPEA 194
+ GL A + L+E A L+L L L + PE
Sbjct: 121 CEFGEQQGLLGVAAKA----WAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQ 176
Query: 195 RLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVLPARVKGLIIQ 254
L + W+R +P R AH ELL V VP ++++ + L+
Sbjct: 177 SRLEALMRWVRHDPQA-RAAHLPELLSLVHLDAVPRPCVQQLLASEPLI----------- 224
Query: 255 ALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQVAAPEP 314
+ R L QG G A + +EEV GQ
Sbjct: 225 ---QESEACRAALSQGHD-------------GAPLALQQKLEEVLV---VVGGQA----- 260
Query: 315 EEEEEELEEEEEEEEWELTQNVVAFDVYN---HRWRSLTQLPT-PLLGHSVCTAGNFLFV 370
LEEEE E E T + F YN RW +L P G S+ N ++V
Sbjct: 261 ------LEEEEAGE--EPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYV 312
Query: 371 LGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAV 430
GG G+ + + T Q + + +W V M + R + A+ + +
Sbjct: 313 TGGS--RGTKTDTWS------TTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVI 364
Query: 431 GGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGA 490
GG + VE YD D WT + + + A G RG +Y+ G A + A
Sbjct: 365 GGTTLD---VVEVESYDPYTDSWTPVSPALKYV-SNFSAAGCRGRLYLVGSSACKYNALA 420
Query: 491 SSLRDLYVLGPEEQVWSKKAPMGTARF--GHHMAVLRGAVFAFLGRYEPFSEIERYDPGA 548
L P WS A ++ A L G ++ +G + ++ YDPGA
Sbjct: 421 -----LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELY-LIG--DNTKKVYVYDPGA 472
Query: 549 DQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCA 608
+ W +++ + G V AL + G +W+ + YD D W G A
Sbjct: 473 NLWQKVQS-QHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHG-A 530
Query: 609 LPWAW 613
LP W
Sbjct: 531 LPRLW 535
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,813,179
Number of Sequences: 37866
Number of extensions: 1330895
Number of successful extensions: 17118
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 367
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 11649
Number of HSP's gapped (non-prelim): 3006
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.