Search of human proteins with 229577123

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|229577123 t-complex-associated testis expressed 1 [Homo
sapiens]
         (501 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]  1011   0.0  
gi|118918429 NOD3 protein [Homo sapiens]                              113   5e-25
gi|168986655 hypothetical protein LOC145497 [Homo sapiens]             82   1e-15
gi|5174617 nucleotide-binding oligomerization domain containing ...    81   2e-15
gi|11545912 nucleotide-binding oligomerization domain containing...    80   4e-15
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    70   4e-12
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...    69   8e-12
gi|23503285 leucine rich repeat containing 34 [Homo sapiens]           66   8e-11
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]      63   5e-10
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...    62   2e-09
gi|21450705 leucine rich repeat containing 45 [Homo sapiens]           62   2e-09
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...    61   2e-09
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]      60   5e-09
gi|61175232 hypothetical protein LOC221424 [Homo sapiens]              60   6e-09
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]     59   8e-09
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ...    57   3e-08
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ...    57   3e-08
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ...    57   3e-08
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]    55   1e-07
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...    55   1e-07
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              55   1e-07
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]              55   2e-07
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...    54   3e-07
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]           54   3e-07

>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
          Length = 501

 Score = 1011 bits (2614), Expect = 0.0
 Identities = 501/501 (100%), Positives = 501/501 (100%)

Query: 1   MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRR 60
           MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRR
Sbjct: 1   MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRR 60

Query: 61  MRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAV 120
           MRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAV
Sbjct: 61  MRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAV 120

Query: 121 TANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDL 180
           TANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDL
Sbjct: 121 TANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDL 180

Query: 181 LPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHL 240
           LPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHL
Sbjct: 181 LPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHL 240

Query: 241 EELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIII 300
           EELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIII
Sbjct: 241 EELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIII 300

Query: 301 RSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH 360
           RSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH
Sbjct: 301 RSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH 360

Query: 361 NTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTL 420
           NTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTL
Sbjct: 361 NTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTL 420

Query: 421 TSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQR 480
           TSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQR
Sbjct: 421 TSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQR 480

Query: 481 ALNPSHFMSTITANGPENSVG 501
           ALNPSHFMSTITANGPENSVG
Sbjct: 481 ALNPSHFMSTITANGPENSVG 501


>gi|118918429 NOD3 protein [Homo sapiens]
          Length = 1065

 Score =  113 bits (282), Expect = 5e-25
 Identities = 68/205 (33%), Positives = 109/205 (53%), Gaps = 1/205 (0%)

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGA-AK 329
           +A A+K   +LK    + + + D  A+ +  +L  +  LE LDL  N I D G       
Sbjct: 770 MADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGA 829

Query: 330 LLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTN 389
           L ++  L  L+L  N +   GAQ++AHAL  N+ L +L+L  N + D+G +A+A A++ N
Sbjct: 830 LCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVREN 889

Query: 390 KCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLL 449
           + LT+LHL  N +    A  L Q L +N +LTS++L  N IG DG   +   +  N  L 
Sbjct: 890 RTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALT 949

Query: 450 EFDLRLSDVAQESEYLIGQALYANR 474
              L+++ +      ++G+AL  NR
Sbjct: 950 ALYLQVASIGASGAQVLGEALAVNR 974



 Score =  108 bits (270), Expect = 1e-23
 Identities = 76/221 (34%), Positives = 111/221 (50%), Gaps = 2/221 (0%)

Query: 254 MNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELD 313
           +  + N F     + L    + K C   KI  L  +++ +  A+ + RSLL +  L  LD
Sbjct: 642 LRLDTNQFQDPVMELLGSVLSGKDCRIQKI-SLAENQISNKGAKALARSLLVNRSLTSLD 700

Query: 314 LSQNLIGDRGARGAAKLLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLN 372
           L  N IG +GA+  A  L  +R L  L+L  N VR  GA+S+A ALA N  L  L+L+ N
Sbjct: 701 LRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKN 760

Query: 373 CIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGL 432
            I   G Q +A AL+ N+ L  L    N + +  A  L++ L +N  L S++L  N I  
Sbjct: 761 SIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISD 820

Query: 433 DGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYAN 473
            G   L+  +  N+TLL   LR + ++ E    I  AL AN
Sbjct: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCAN 861



 Score =  105 bits (261), Expect = 1e-22
 Identities = 69/205 (33%), Positives = 108/205 (52%), Gaps = 1/205 (0%)

Query: 270  SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
            +L  A+    TL    L  + +  + A+ I  +L  +  L+ LDL+ NL+ D+GAR  A 
Sbjct: 825  ALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAV 884

Query: 330  LLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQT 388
             +  +R L  L+L  N ++A  AQ+L  AL  N +L SL+L+ N I D+G  A+A AL+ 
Sbjct: 885  AVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKV 944

Query: 389  NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTL 448
            N  LT L+L    +    A +L + LA+N TL  ++L  N IG+ G K L   +  N +L
Sbjct: 945  NTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSL 1004

Query: 449  LEFDLRLSDVAQESEYLIGQALYAN 473
               +L+ + +  +    I  AL  N
Sbjct: 1005 RRLNLQENSLGMDGAICIATALSGN 1029



 Score =  104 bits (260), Expect = 2e-22
 Identities = 71/206 (34%), Positives = 109/206 (52%), Gaps = 1/206 (0%)

Query: 270 SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
           +LA A+K   TL    L  + V DD AR +  +L  +  L  L L +N IG  GA+  A 
Sbjct: 713 ALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMAD 772

Query: 330 LLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQT 388
            L  +R L+ L  ++N +   GA++LA AL  N  L SL+L+ N I D G  AL  AL T
Sbjct: 773 ALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCT 832

Query: 389 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTL 448
           N+ L +L L  N +S   A  ++  L  N+TL +++L+ N +   G + +   + +N+TL
Sbjct: 833 NQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTL 892

Query: 449 LEFDLRLSDVAQESEYLIGQALYANR 474
               L+ + +   +   +GQAL  NR
Sbjct: 893 TSLHLQWNFIQAGAAQALGQALQLNR 918



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 67/210 (31%), Positives = 107/210 (50%), Gaps = 1/210 (0%)

Query: 270  SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
            +LA A+K    L+   L  + + D     ++ +L  +  L  L L +N I   GA+  A 
Sbjct: 797  ALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAH 856

Query: 330  LL-SHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQT 388
             L ++S L+ L+L  N +   GA+++A A+  N  L SL+L+ N I+    QAL  ALQ 
Sbjct: 857  ALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQL 916

Query: 389  NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTL 448
            N+ LT+L L  N + +  A  +++ L +NT LT++ L    IG  G + L E ++ N+TL
Sbjct: 917  NRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTL 976

Query: 449  LEFDLRLSDVAQESEYLIGQALYANREAAR 478
               DLR + +       +  AL  N    R
Sbjct: 977  EILDLRGNAIGVAGAKALANALKVNSSLRR 1006



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 56/181 (30%), Positives = 99/181 (54%), Gaps = 5/181 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAK-LLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISL 367
           ++++ L++N I ++GA+  A+ LL +  L  L+L  N +   GA++LA AL  N  L SL
Sbjct: 668 IQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSL 727

Query: 368 NLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           +L+ N + D+G +++A AL +N+ L+ LHL  N +    A  ++  L  N +L  +  S 
Sbjct: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSS 787

Query: 428 NHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANRE----AARQRALN 483
           N IG  G K L E +  N+ L   DL+ + ++      +  AL  N+     + R+ +++
Sbjct: 788 NSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSIS 847

Query: 484 P 484
           P
Sbjct: 848 P 848



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 48/140 (34%), Positives = 83/140 (59%)

Query: 335 RLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTT 394
           R++ ++LA NQ+   GA++LA +L  N +L SL+LR N I  +G +ALA AL+ N+ LT+
Sbjct: 667 RIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726

Query: 395 LHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLR 454
           L L GN + +  A  +++ LA N TL+ ++L  N IG  G +++ + +  N++L E    
Sbjct: 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFS 786

Query: 455 LSDVAQESEYLIGQALYANR 474
            + +       + +AL  N+
Sbjct: 787 SNSIGDGGAKALAEALKVNQ 806



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 46/157 (29%), Positives = 82/157 (52%), Gaps = 1/157 (0%)

Query: 270  SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
            +L  A++   +L    L  + + DD A  + R+L  +  L  L L    IG  GA+   +
Sbjct: 909  ALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGE 968

Query: 330  LLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQT 388
             L+ +R L +L+L  N +   GA++LA+AL  N++L  LNL+ N +  +G   +A AL  
Sbjct: 969  ALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSG 1028

Query: 389  NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
            N  L  ++L GN + +  A ++S+ +  N    ++ +
Sbjct: 1029 NHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM 1065


>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
          Length = 488

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 54/180 (30%), Positives = 91/180 (50%), Gaps = 2/180 (1%)

Query: 297 RIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR-LRVLNLANNQVRAPGAQSLA 355
           + I  +L+ +  + +L+L  N I + G     ++L  +  L+ +N++NN +   GA+ ++
Sbjct: 123 KAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIIS 182

Query: 356 HALAHNTNLI-SLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVL 414
                N++ I SL L  N  +++    L  AL TN  +  L L  N+ S+     L Q+L
Sbjct: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQML 242

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANR 474
           AIN  LTS++LS N+    G   L  G+  N TL + DL ++    E    +G+ L  NR
Sbjct: 243 AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNR 302



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/182 (28%), Positives = 93/182 (51%), Gaps = 1/182 (0%)

Query: 285 KLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS-HSRLRVLNLAN 343
           +L+ +   +D A ++ ++L  +  +++LDLS N   D G     ++L+ +  L  L+L+ 
Sbjct: 196 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSW 255

Query: 344 NQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELS 403
           N     GA +L + L  N  L  L+L +N   +E   AL   L+ N+CL  L +GGN++ 
Sbjct: 256 NNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIG 315

Query: 404 EPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
              A+ +S+ L  N +L  + L  N I +DG   L+  +  N      +L +S+V    +
Sbjct: 316 NEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQ 375

Query: 464 YL 465
           ++
Sbjct: 376 FM 377



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 56/210 (26%), Positives = 96/210 (45%), Gaps = 2/210 (0%)

Query: 266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGAR 325
           R   ++A A+ +   +   +L  + + ++    ++  L ++  L+E+++S N +G  GAR
Sbjct: 120 RGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGAR 179

Query: 326 GAAKLLSHSRLRV--LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALA 383
             +     +   +  L L+ N  +   A  L  AL+ N  +  L+L  N   D GG+ L 
Sbjct: 180 IISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLG 239

Query: 384 HALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMS 443
             L  N  LT+L L  N      A  L   L  N TLT ++LS N  G +    L E + 
Sbjct: 240 QMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLR 299

Query: 444 DNKTLLEFDLRLSDVAQESEYLIGQALYAN 473
            N+ L+  D+  +D+  E    I + L +N
Sbjct: 300 LNRCLVYLDIGGNDIGNEGASKISKGLESN 329



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 1/108 (0%)

Query: 367 LNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
           +NL  + +   G +A+A AL +N  +T L L  N + E     L ++L  N  L  +N+S
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169

Query: 427 CNHIGLDGGKQLLEGMSDN-KTLLEFDLRLSDVAQESEYLIGQALYAN 473
            NH+GL+G + + +    N  ++   +L  +D  ++S  L+ QAL  N
Sbjct: 170 NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTN 217



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 40/144 (27%), Positives = 67/144 (46%), Gaps = 6/144 (4%)

Query: 219 EMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKAC 278
           ++++  + H Q  D+  G  HL ++ L  +V    ++  WN F    R  ++L   ++  
Sbjct: 219 QIKKLDLSHNQFSDV--GGEHLGQM-LAINVGLTSLDLSWNNF--HTRGAVALCNGLRGN 273

Query: 279 HTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK-LLSHSRLR 337
            TL    L+ +   ++ A  +   L  +  L  LD+  N IG+ GA   +K L S+  LR
Sbjct: 274 VTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLR 333

Query: 338 VLNLANNQVRAPGAQSLAHALAHN 361
           VL L  N +   GA  L  A+  N
Sbjct: 334 VLKLFLNPINMDGAILLILAIKRN 357


>gi|5174617 nucleotide-binding oligomerization domain containing 1
           [Homo sapiens]
          Length = 953

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 56/169 (33%), Positives = 89/169 (52%), Gaps = 1/169 (0%)

Query: 286 LTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR-LRVLNLANN 344
           L  +++ D  AR + + L +   L  L L +N I   G +  A  + +S+ +  + +  N
Sbjct: 763 LYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGN 822

Query: 345 QVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE 404
           QV   GA++ A AL ++ +L +L+L  N I  EGG++LA ALQ N  L  L L  NEL++
Sbjct: 823 QVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELND 882

Query: 405 PTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDL 453
             A  L+++L +N TL  + L  N I   G  QL + +  N  + E  L
Sbjct: 883 EVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICL 931



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 53/194 (27%), Positives = 98/194 (50%), Gaps = 1/194 (0%)

Query: 281 LKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR-LRVL 339
           L + +L+ +++ D   +++   L  + ++  L L  N I D GAR   K+L   + L  L
Sbjct: 730 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHL 789

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGG 399
            L  N++ + G + LA A+ ++ ++  + +  N + DEG +A A AL+ +  LTTL L  
Sbjct: 790 KLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLAS 849

Query: 400 NELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVA 459
           N +S      L++ L  NT+L  + L+ N +  +  + L E +  N+TL    L  + + 
Sbjct: 850 NGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQIT 909

Query: 460 QESEYLIGQALYAN 473
            +    +  AL +N
Sbjct: 910 AKGTAQLADALQSN 923



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 50/154 (32%), Positives = 82/154 (53%), Gaps = 1/154 (0%)

Query: 278 CHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLL-SHSRL 336
           C  L   KL ++K+  +  + +  ++ +   + E+ +  N +GD GA+  A+ L +H  L
Sbjct: 783 CKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSL 842

Query: 337 RVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLH 396
             L+LA+N +   G +SLA AL  NT+L  L L  N + DE  ++LA  L+ N+ L  L 
Sbjct: 843 TTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLW 902

Query: 397 LGGNELSEPTATLLSQVLAINTTLTSINLSCNHI 430
           L  N+++      L+  L  NT +T I L+ N I
Sbjct: 903 LIQNQITAKGTAQLADALQSNTGITEICLNGNLI 936



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 48/167 (28%), Positives = 85/167 (50%), Gaps = 1/167 (0%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRL-RVLNLANNQVRAPGAQSLAHALAHNTNLISL 367
           L  L LS N I D G +  ++ L+  ++   L L NNQ+   GA+ +   L     L  L
Sbjct: 730 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHL 789

Query: 368 NLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
            L  N I  EGG+ LA A++ +K ++ + + GN++ +  A   ++ L  + +LT+++L+ 
Sbjct: 790 KLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLAS 849

Query: 428 NHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANR 474
           N I  +GGK L   +  N +L    L  +++  E    + + L  N+
Sbjct: 850 NGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQ 896



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/131 (33%), Positives = 67/131 (51%), Gaps = 1/131 (0%)

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330
           LA A+K   ++    +  ++V D+ A+    +L +HP L  L L+ N I   G +  A+ 
Sbjct: 804 LALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARA 863

Query: 331 L-SHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTN 389
           L  ++ L +L L  N++    A+SLA  L  N  L  L L  N I  +G   LA ALQ+N
Sbjct: 864 LQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSN 923

Query: 390 KCLTTLHLGGN 400
             +T + L GN
Sbjct: 924 TGITEICLNGN 934



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 1/109 (0%)

Query: 270 SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
           + A A++   +L    L  + +  +  + + R+L  +  LE L L+QN + D  A   A+
Sbjct: 831 AFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE 890

Query: 330 LLS-HSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDE 377
           +L  +  L+ L L  NQ+ A G   LA AL  NT +  + L  N I+ E
Sbjct: 891 MLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPE 939


>gi|11545912 nucleotide-binding oligomerization domain containing 2
            [Homo sapiens]
          Length = 1040

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 65/193 (33%), Positives = 88/193 (45%), Gaps = 1/193 (0%)

Query: 282  KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS-HSRLRVLN 340
            K   L  + + D     +I   L    L++L L  N + D  A   AKLL+       L 
Sbjct: 818  KALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALR 877

Query: 341  LANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGN 400
            L NN + A GAQ LA  L  NT+L  L    N + DEG QALA AL  ++ L  L L GN
Sbjct: 878  LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGN 937

Query: 401  ELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQ 460
             +    A  L+ +LA N  L  + L  NH+  +G   L EG+  N +L    L  + +  
Sbjct: 938  NIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITY 997

Query: 461  ESEYLIGQALYAN 473
                 + QAL  N
Sbjct: 998  LGAEALLQALERN 1010



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 4/184 (2%)

Query: 268  CLSLAAAIKACH-TLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARG 326
            C    A + AC       +L  + +    A+++   L  +  L+ L    N +GD GA+ 
Sbjct: 859  CAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQA 918

Query: 327  AAKLLS-HSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHA 385
             A+ L  H  LR L+L  N + + GAQ+LA  LA N  L  L L  N ++DEG  +LA  
Sbjct: 919  LAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEG 978

Query: 386  LQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDN 445
            L+ N  L  L L  N ++   A  L Q L  N T+  + L  N   L+   +L  G  D 
Sbjct: 979  LKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKL--GCRDT 1036

Query: 446  KTLL 449
            + LL
Sbjct: 1037 RLLL 1040



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 60/178 (33%), Positives = 85/178 (47%), Gaps = 1/178 (0%)

Query: 278  CHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK-LLSHSRL 336
            C  L+   L  +K+ D  A  + + L        L L  N I   GA+  A+ L  ++ L
Sbjct: 842  CEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSL 901

Query: 337  RVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLH 396
            + L    N+V   GAQ+LA AL  + +L  L+L  N I   G QALA  L  N  L  L 
Sbjct: 902  QFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELC 961

Query: 397  LGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLR 454
            L  N L +     L++ L  N++L  + LS N I   G + LL+ +  N T+LE  LR
Sbjct: 962  LEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLR 1019


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
            sapiens]
          Length = 1866

 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 19/234 (8%)

Query: 230  LGDLVAGLSH---LEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKL 286
            L  L +GL H   LEELDL  +              F      +L  A++    LK   L
Sbjct: 1511 LAHLASGLGHCHHLEELDLSNNQ-------------FDEEGTKALMRALEGKWMLKRLDL 1557

Query: 287  TRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLL-SHSRLRVLNLANNQ 345
            +   ++     ++   L     L+ L L++N IGD G    ++ L + + L  L+L++NQ
Sbjct: 1558 SHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQ 1617

Query: 346  VRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEP 405
            +   G Q LA  L     L  ++L  N I   GG  LA +L   + L  L LG N L +P
Sbjct: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677

Query: 406  TATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVA 459
            TA  L+Q L  +  L  ++L  +H+G  G   L + +  +  L E  L  +++A
Sbjct: 1678 TALGLAQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA 1729



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 53/149 (35%), Positives = 72/149 (48%), Gaps = 4/149 (2%)

Query: 309  LEELDLSQ-NLIGDRGARGA---AKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNL 364
            L++L LSQ NL  D  A      + LLS S L+   L ++ V   G   LA  L H  +L
Sbjct: 1465 LQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL 1524

Query: 365  ISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSIN 424
              L+L  N  ++EG +AL  AL+    L  L L    L+  T  LL+  L+  T L S+ 
Sbjct: 1525 EELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLR 1584

Query: 425  LSCNHIGLDGGKQLLEGMSDNKTLLEFDL 453
            L+ N IG  G   L E +    +L E DL
Sbjct: 1585 LNRNSIGDVGCCHLSEALRAATSLEELDL 1613



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 53/206 (25%), Positives = 91/206 (44%), Gaps = 4/206 (1%)

Query: 269  LSLAAAIKACHTLKIFKLTRSKV--DDDKARIIIRSLL-DHPVLEELDLSQNLIGDRGAR 325
            L +   ++ C  L+   L++  +  DDD + ++++SLL     L+   L+ + +   G  
Sbjct: 1453 LLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLA 1512

Query: 326  GAAKLLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAH 384
              A  L H   L  L+L+NNQ    G ++L  AL     L  L+L    +       L H
Sbjct: 1513 HLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTH 1572

Query: 385  ALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSD 444
             L    CL +L L  N + +     LS+ L   T+L  ++LS N IG  G + L   +  
Sbjct: 1573 RLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPG 1632

Query: 445  NKTLLEFDLRLSDVAQESEYLIGQAL 470
               L + DL  + ++      + ++L
Sbjct: 1633 LPELRKIDLSGNSISSAGGVQLAESL 1658



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 48/154 (31%), Positives = 70/154 (45%), Gaps = 18/154 (11%)

Query: 230  LGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRS 289
            L   + G  HLEE+ L           E NL     R C+ L         L+   L   
Sbjct: 1708 LAQALDGSPHLEEISLA----------ENNLAGGVLRFCMELPL-------LRQIDLVSC 1750

Query: 290  KVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-SRLRVLNLANNQVRA 348
            K+D+  A+++  S    P LE + LS NL+GD  A   A++L    RL+ ++L  NQ+ A
Sbjct: 1751 KIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITA 1810

Query: 349  PGAQSLAHALAHNTNLISLNLRLNCIEDEGGQAL 382
             GA  LA  LA  +++  + L  N I  +  Q L
Sbjct: 1811 LGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 62/244 (25%), Positives = 100/244 (40%), Gaps = 40/244 (16%)

Query: 230  LGDLVAGLSHLEELDLVYD-VKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTR 288
            L + +   + LEELDL ++ + D G+                LA  +     L+   L+ 
Sbjct: 1598 LSEALRAATSLEELDLSHNQIGDAGVQH--------------LATILPGLPELRKIDLSG 1643

Query: 289  SKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRA 348
            + +       +  SL+    LEEL L  N +GD  A G A+ L    LRVL+L  + +  
Sbjct: 1644 NSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQ-HLRVLHLPFSHLGP 1702

Query: 349  PGAQSLAHALAHNTNLISLNLRLN-----------------------C-IEDEGGQALAH 384
             GA SLA AL  + +L  ++L  N                       C I+++  + L  
Sbjct: 1703 GGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTS 1762

Query: 385  ALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSD 444
            +  +   L  + L  N L +  A  L+QVL     L  ++L  N I   G   L EG++ 
Sbjct: 1763 SFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1822

Query: 445  NKTL 448
              ++
Sbjct: 1823 GSSI 1826



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 57/233 (24%), Positives = 97/233 (41%), Gaps = 56/233 (24%)

Query: 285  KLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRL-RVLNLAN 343
            +L + ++    A  +I  L + P LEE+DLS N + D G R  A+  S   + R L+L++
Sbjct: 848  RLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSD 907

Query: 344  NQVRAPGAQSLAHALAHNTNLISLNLRL-------------------------------- 371
            N +   G   +  A++    L  L++ L                                
Sbjct: 908  NGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQ 967

Query: 372  ---------------NC-IEDEGGQALAHALQTNKCLTTLHL--GGNELSEPTATLLSQV 413
                           +C ++++  + L  AL  +  L  LHL   GN L +  A  L+Q+
Sbjct: 968  MPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQL 1027

Query: 414  LAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLI 466
            L     L S+NLS N + LD    L+   S     L++  RL D++ ES++++
Sbjct: 1028 LPGLGALQSLNLSENGLSLDAVLGLVRCFS----TLQWLFRL-DISFESQHIL 1075


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 47/151 (31%), Positives = 78/151 (51%), Gaps = 2/151 (1%)

Query: 302  SLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
            +LL +  L  L+LS+N + D G +   + L      L+ LNL+       G   LA+AL+
Sbjct: 890  ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949

Query: 360  HNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTT 419
            HN N+  L+L  N ++D+G + L  AL+ ++ L TL L    L+      L  VL+ + +
Sbjct: 950  HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009

Query: 420  LTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
            L ++NL  N +  DG K L + +  +   L+
Sbjct: 1010 LVNLNLLGNELDTDGVKMLCKALKKSTCRLQ 1040



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 55/207 (26%), Positives = 98/207 (47%), Gaps = 5/207 (2%)

Query: 268  CLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHP--VLEELDLSQNLIGDRGAR 325
            C  LA  + +   +    L  +++ DD  +++  +L  HP   LE L+L    +     +
Sbjct: 827  CQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALT-HPKCALERLELWFCQLAAPACK 885

Query: 326  GAAKLLSHSR-LRVLNLANNQVRAPGAQSLAHALAH-NTNLISLNLRLNCIEDEGGQALA 383
              +  L  +R L  LNL+ N +R  G + L  AL   + NL SLNL       EG   LA
Sbjct: 886  HLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELA 945

Query: 384  HALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMS 443
            +AL  N  +  L LG N+L +    LL + L  +  L ++ L+  ++     + L   +S
Sbjct: 946  NALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLS 1005

Query: 444  DNKTLLEFDLRLSDVAQESEYLIGQAL 470
             +K+L+  +L  +++  +   ++ +AL
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKAL 1032



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 53/165 (32%), Positives = 76/165 (46%), Gaps = 5/165 (3%)

Query: 282 KIFKLTRSKVDDDKA-RIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS--RLRV 338
           K+ KLT   V  +   + +I +L  +  L  L+ S N +G        K L HS   L+ 
Sbjct: 756 KVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKY 814

Query: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHL 397
           L L    + A   Q LA  L    ++  L L  N ++D+G + L  AL   KC L  L L
Sbjct: 815 LCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874

Query: 398 GGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
              +L+ P    LS  L  N +LT +NLS N +  +G K L E +
Sbjct: 875 WFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEAL 919


>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
          Length = 419

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 53/195 (27%), Positives = 81/195 (41%), Gaps = 28/195 (14%)

Query: 312 LDLSQNLIGDRGARGAAKLLSHS-RLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLR 370
           LD+  NL+ D GA  AAKLL     L  LNL  N +   G + +A  L  N  L  L + 
Sbjct: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174

Query: 371 LNCIEDEGGQALAHALQTNK---------------------------CLTTLHLGGNELS 403
            N IE++GG   A  LQ N                            CL  LH+  +++ 
Sbjct: 175 GNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIK 234

Query: 404 EPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
                 L   L +N++L  +++SCN I  DG   L + +  N TL   DL  + +     
Sbjct: 235 NSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGA 294

Query: 464 YLIGQALYANREAAR 478
             + + L ++  + +
Sbjct: 295 NYLSETLTSHNRSLK 309



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 46/178 (25%), Positives = 83/178 (46%), Gaps = 1/178 (0%)

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330
           +A  +    TLK  ++T +K+++         L  +  LE+LDL    + +        L
Sbjct: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRML 217

Query: 331 LSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNK 390
             +  L  L++  + ++  G Q L  AL  N++L  L++  N I  +G   LA  L++N 
Sbjct: 218 KENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT 277

Query: 391 CLTTLHLGGNELSEPTATLLSQVL-AINTTLTSINLSCNHIGLDGGKQLLEGMSDNKT 447
            L  + L  N +    A  LS+ L + N +L ++++  N+I  +G   L + M  N T
Sbjct: 278 TLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 54/205 (26%), Positives = 95/205 (46%), Gaps = 17/205 (8%)

Query: 238 SHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKAR 297
           S LE+LDL     DC +              + +   +K  H L    + +  + +   +
Sbjct: 194 SSLEKLDL----GDCDLE----------ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQ 239

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLL-SHSRLRVLNLANNQVRAPGAQSLAH 356
            +  +L  +  L  LD+S N I   G    A +L S++ L V++L+ N++   GA  L+ 
Sbjct: 240 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSE 299

Query: 357 AL-AHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLA 415
            L +HN +L +L++  N IE EG  AL+ +++TN   + +++ GN+  E T    S ++ 
Sbjct: 300 TLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQ 359

Query: 416 INTTLTSINLSCNHIGLDGGKQLLE 440
           +   L   N       +DG   L E
Sbjct: 360 MG-CLKPDNTDVEPFVVDGRVYLAE 383



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 26/113 (23%), Positives = 51/113 (45%), Gaps = 4/113 (3%)

Query: 336 LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTL 395
           L +L   + +++   A  +   +A N  L+ +      +  E    L+  L+    +  L
Sbjct: 60  LHILQEVDEEIKKGLAAGITLNIAGNNRLVPVER----VTGEDFWILSKILKNCLYINGL 115

Query: 396 HLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTL 448
            +G N L +  A   +++L     L  +NL  N IG +GG+ + + +  N+TL
Sbjct: 116 DVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTL 168


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 51/149 (34%), Positives = 76/149 (51%), Gaps = 4/149 (2%)

Query: 294 DKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGA 351
           D  + I  SL+ +  L  LDL  + IGD G +   + L H   +L+ L L +  +     
Sbjct: 716 DGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCC 775

Query: 352 QSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLL 410
            ++++AL  + +LI LNL  N + D+G Q L  AL+  KC L  L L    L+E     L
Sbjct: 776 LNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835

Query: 411 SQVLAINTTLTSINLSCNHIGLDGGKQLL 439
           S  L  N  LT + L+ N +G DGG +L+
Sbjct: 836 SLALISNKRLTHLCLADNVLG-DGGVKLM 863



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 3/174 (1%)

Query: 280  TLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS--RLR 337
            TLK   L R       +  +  SLL +  L  LDL  N + D G +    +  H    L+
Sbjct: 873  TLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQ 932

Query: 338  VLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLH 396
             L L    +       LA  + +N NL SL+L  N ++D+G + L  AL+   C +  L 
Sbjct: 933  DLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG 992

Query: 397  LGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
            L    L+      LS  L  N  L  +NL+ N +G +G  +L + +   K  L+
Sbjct: 993  LEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQ 1046



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 44/144 (30%), Positives = 69/144 (47%), Gaps = 2/144 (1%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAP-GAQSLAHALAHNTNLISL 367
           L ELDL  + +           L H   ++  L    +  P G Q ++ +L HN NL+ L
Sbjct: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734

Query: 368 NLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
           +L+ + I D G ++L  AL+  +C L TL L    L+      +S  L  + +L  +NLS
Sbjct: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794

Query: 427 CNHIGLDGGKQLLEGMSDNKTLLE 450
            N++  DG + L E +   K  LE
Sbjct: 795 TNNLLDDGVQLLCEALRHPKCYLE 818



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 3/144 (2%)

Query: 302 SLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR--LRVLNLANNQVRAPGAQSLAHALA 359
           +L+ +  L  L L+ N++GD G +  +  L H++  L+ L L      +  ++ L+ +L 
Sbjct: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINT 418
           HN +L  L+L  N ++D G + L    +   C L  L L G  L+      L+ V+  N 
Sbjct: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957

Query: 419 TLTSINLSCNHIGLDGGKQLLEGM 442
            L S++L  N +  DG K L + +
Sbjct: 958 NLRSLDLGNNDLQDDGVKILCDAL 981


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
           sapiens]
          Length = 1061

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 55/165 (33%), Positives = 79/165 (47%), Gaps = 3/165 (1%)

Query: 281 LKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRV 338
           L++ +L + +++    + +   L  +P L ELDL+ N + D G R   + L H   RLR 
Sbjct: 801 LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 860

Query: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHL 397
           L L   ++ A     LA  L+ N +L  L+L LN + D G   L   L+   C L TL L
Sbjct: 861 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920

Query: 398 GGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
           G   L       LS VL  N  L  ++LS N +G  G   L EG+
Sbjct: 921 GICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGL 965



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 57/230 (24%), Positives = 102/230 (44%), Gaps = 4/230 (1%)

Query: 217 EGEMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYR-DCLSLAAAI 275
           E E  +  + H+Q+  +    S +E +   + +K C      +L+  TY  D    A   
Sbjct: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681

Query: 276 KACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-- 333
              HTL +    R+ + D  +  +  +L  +P L EL L +N +G RG +   + L H  
Sbjct: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741

Query: 334 SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-L 392
            +L+ L L   ++ +   + L+ AL  N NL  ++L  N +   G   L   L+  +C L
Sbjct: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801

Query: 393 TTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
             + L   +L       ++ VL  N  L  ++L+ N +   G + L +G+
Sbjct: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGL 851



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 40/122 (32%), Positives = 58/122 (47%), Gaps = 6/122 (4%)

Query: 309  LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
            L ELDLS N +GD G    A+ L H   RL+ L L +  + A   ++L   L  N  L  
Sbjct: 943  LRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTD 1002

Query: 367  LNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
            L L  N + D G + L   L    C L  L L G +L++ T    S++ A+  T   +++
Sbjct: 1003 LYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH---SRLAALRVTKPYLDI 1059

Query: 426  SC 427
             C
Sbjct: 1060 GC 1061



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 14/103 (13%)

Query: 239  HLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARI 298
            +L ELDL ++  D G   +W L+L      L+      AC   K++ L    +       
Sbjct: 942  NLRELDLSFN--DLG---DWGLWL------LAEGLQHPACRLQKLW-LDSCGLTAKACEN 989

Query: 299  IIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVL 339
            +  +L  +  L +L L+ N +GD G R   K LSH   +LRVL
Sbjct: 990  LYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 1032


>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
          Length = 670

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 61/235 (25%), Positives = 95/235 (40%), Gaps = 38/235 (16%)

Query: 286 LTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR---------- 335
           L+   + ++ A +++R L  + VL  LDL  N +   GA    KLL  ++          
Sbjct: 65  LSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWN 124

Query: 336 ---------------------LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCI 374
                                L+ L+L NNQ+   GA+ LA AL  NT L  L+LR N +
Sbjct: 125 SLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNV 184

Query: 375 EDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAIN---TTLTSINLSCNHIG 431
              GG+AL + L +N+ L  L L GN +       + Q +  +    T    N +  H+ 
Sbjct: 185 GLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHV- 243

Query: 432 LDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQRALNPSH 486
                + ++ + + K+    DL  +   Q  E        A R    Q ALN  H
Sbjct: 244 ---LSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERH 295



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 37/137 (27%), Positives = 56/137 (40%), Gaps = 2/137 (1%)

Query: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLG 398
           L+LA   +     ++L   L   T    L L    + +EG   L   L  N  L  L L 
Sbjct: 35  LDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLK 94

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGL--DGGKQLLEGMSDNKTLLEFDLRLS 456
           GN L    A  L ++L  N ++ S+ L  N +G   D       G++ N  L   DLR +
Sbjct: 95  GNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNN 154

Query: 457 DVAQESEYLIGQALYAN 473
            ++ +    +  AL  N
Sbjct: 155 QISHKGAEELALALKGN 171



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 28/115 (24%), Positives = 53/115 (46%), Gaps = 3/115 (2%)

Query: 254 MNFEWNLFLFTYRDCLS-LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEEL 312
           +  EWN  L T+ D  +     + A   L+   L  +++    A  +  +L  +  L++L
Sbjct: 119 LTLEWNS-LGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQL 177

Query: 313 DLSQNLIGDRGARGAAKLLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           DL  N +G  G R     L  +R L  L+LA N +     +++  A+ H+ + ++
Sbjct: 178 DLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLT 232



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 23/84 (27%), Positives = 37/84 (44%)

Query: 264 TYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRG 323
           +++    LA A+K   TL+   L  + V     R ++  L  +  L  LDL+ N I    
Sbjct: 157 SHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDV 216

Query: 324 ARGAAKLLSHSRLRVLNLANNQVR 347
            R   + + HS+ R+     NQ R
Sbjct: 217 LRAVEQAMGHSQDRLTTFQENQAR 240


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
           sapiens]
          Length = 287

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 47/160 (29%), Positives = 77/160 (48%), Gaps = 3/160 (1%)

Query: 286 LTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLAN 343
           L R ++       +  +L+ +  L  +DLS N +G  G     + L H   RL+++ L  
Sbjct: 32  LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91

Query: 344 NQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNEL 402
            Q+ +   Q +A  L  N +L+ L+L  N +ED G + L   L+   C L TL L    L
Sbjct: 92  CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151

Query: 403 SEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
           +      L+  L++N +L  ++LS N +G  G   L EG+
Sbjct: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGL 191



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 53/166 (31%), Positives = 80/166 (48%), Gaps = 3/166 (1%)

Query: 281 LKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRV 338
           L++ +L + +++    + +   L  +P L ELDL+ N + D G R   + L H   RLR 
Sbjct: 84  LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 143

Query: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHL 397
           L L   ++ A     LA  L+ N +L  L+L LN + D G   L   L+   C L TL L
Sbjct: 144 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203

Query: 398 GGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMS 443
               L+      L   L IN TLT + L+ N +G  G + L + +S
Sbjct: 204 DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 249



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 42/146 (28%), Positives = 65/146 (44%), Gaps = 2/146 (1%)

Query: 327 AAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH-NTNLISLNLRLNCIEDEGGQALAHA 385
           +A L+++  L  ++L+ N V  PG   L   L H    L  + LR   +E    Q +A  
Sbjct: 46  SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 105

Query: 386 LQTNKCLTTLHLGGNELSEPTATLLSQVLAINT-TLTSINLSCNHIGLDGGKQLLEGMSD 444
           L TN  L  L L GN L +    LL Q L      L ++ L    +      +L   +S 
Sbjct: 106 LGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSV 165

Query: 445 NKTLLEFDLRLSDVAQESEYLIGQAL 470
           N++L E DL L+++      L+ + L
Sbjct: 166 NQSLRELDLSLNELGDLGVLLLCEGL 191


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 55/172 (31%), Positives = 78/172 (45%), Gaps = 4/172 (2%)

Query: 299 IIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR--LRVLNLANNQVRAPGAQSLAH 356
           I   LL +  +  LDLS N++ D G +   + L H    L  L L    + A G + LA 
Sbjct: 799 ISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLAS 858

Query: 357 ALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLA 415
           AL  N NL  L +  N I D G Q L  AL    C L  L L    L+      L+ VL 
Sbjct: 859 ALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLT 918

Query: 416 INTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE-FDLRLSDVAQESEYLI 466
            + TL  +NL+ N +   G   L E +   +  L+   LR +D  +E++ L+
Sbjct: 919 CSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALL 970



 Score = 37.7 bits (86), Expect = 0.025
 Identities = 43/175 (24%), Positives = 70/175 (40%), Gaps = 34/175 (19%)

Query: 280 TLKIFKLTRSKVDDDKARIIIRSLLDHP--VLEELDLSQNLIGDRGARG-AAKLLSHSRL 336
           +++   L+ + + D+  + +  +L  HP   L+ L L +  I   G    A+ L+S+  L
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEAL-KHPDCCLDSLCLVKCFITAAGCEDLASALISNQNL 866

Query: 337 RVLNLANNQVRAPGAQSLAHALAH-----------------------------NTNLISL 367
           ++L +  N++   G Q L  AL H                             +  L  L
Sbjct: 867 KILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQL 926

Query: 368 NLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLT 421
           NL LN ++  G   L  AL+  +C L  L L   +  E T  LL+     N  LT
Sbjct: 927 NLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLT 981



 Score = 33.1 bits (74), Expect = 0.61
 Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 1/136 (0%)

Query: 336 LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNC-IEDEGGQALAHALQTNKCLTT 394
           L+ L+    ++     +SL  AL +    +     +NC +     + LA  L  NK LT 
Sbjct: 696 LKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTY 755

Query: 395 LHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLR 454
           L++  N+L      L   + + +T L  + L+  H+     + + E +  NK++   DL 
Sbjct: 756 LNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLS 815

Query: 455 LSDVAQESEYLIGQAL 470
            + +  E    + +AL
Sbjct: 816 ANVLKDEGLKTLCEAL 831


>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
          Length = 316

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 55/182 (30%), Positives = 89/182 (48%), Gaps = 6/182 (3%)

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330
           LA A++   +++   L  S + D    ++  +L  HP L  LDL   ++GD        L
Sbjct: 77  LAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGL 136

Query: 331 L----SHSRLRVLNL-ANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHA 385
           L    + S L+ L L AN  +   G   LA A+AH++ +  LNL  N + D     LA A
Sbjct: 137 LPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVA 196

Query: 386 LQTNKCLTTLHLGGNELSEPTA-TLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSD 444
           + +++ L  L L G  L+  +A TLL  V    T L S+ L+ N I  +  +Q+ + +S+
Sbjct: 197 VASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSE 256

Query: 445 NK 446
            +
Sbjct: 257 GE 258



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 38/145 (26%), Positives = 67/145 (46%), Gaps = 13/145 (8%)

Query: 312 LDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRL 371
           + +S   +     R   + L  + +R+L+L   ++       +  ALA  T+L  LNL L
Sbjct: 6   IQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNL 65

Query: 372 NCIEDEGG-QALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLT--------- 421
             +      + LA AL+TN+ + +L L G+ L++    LL+  LA++  L          
Sbjct: 66  GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCML 125

Query: 422 ---SINLSCNHIGLDGGKQLLEGMS 443
              +INL C  +  DG K  L+ ++
Sbjct: 126 GDEAINLICGLLPPDGAKSGLKELT 150


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 6/171 (3%)

Query: 301 RSLLDHPVLEELDLSQNLIGDRGARGAA--KLLSHSRLRVLNLANNQVRAPGAQSLAHAL 358
           R LL  P L +LDL  N + + G        L    +L  L+L+     +   Q +A  +
Sbjct: 797 RVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVI 856

Query: 359 AHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNE--LSEPTATLLSQVLAI 416
           A N  L SL +  N IED G Q L   L+   C+  +++G  E  L+      L+ VL  
Sbjct: 857 ATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML-VNIGLEECMLTSACCRSLASVLTT 915

Query: 417 NTTLTSINLSCNHIGLDGGKQLLEGM-SDNKTLLEFDLRLSDVAQESEYLI 466
           N TL  +NL  NH+G DG  +LLE + S +  L    L L+ +  +++ L+
Sbjct: 916 NKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966


>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 56/191 (29%), Positives = 88/191 (46%), Gaps = 3/191 (1%)

Query: 266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGA 324
           R  + LA A+K    L+   L  +K++  +    + +LL     L+ LDL  N + D G 
Sbjct: 247 RPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGL 306

Query: 325 RGAAKLLSHSR--LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQAL 382
               + L   R  L  L L NNQ+   G   L   L H  +L +LNL  N I +EG + L
Sbjct: 307 AYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366

Query: 383 AHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
            + L +N+ +  L L   +L+   A  +++ +A +  L  ++L  N I   G   L   +
Sbjct: 367 KNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426

Query: 443 SDNKTLLEFDL 453
             N +LL  DL
Sbjct: 427 KVNHSLLRLDL 437



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 4/218 (1%)

Query: 254 MNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELD 313
           +N  +N  + T R   + A  ++    L+      + + D  A  + R+L     L  L 
Sbjct: 180 LNISFNKHIGT-RGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 314 LSQNLIGDRGARGAAKLLS-HSRLRVLNLANNQVRA-PGAQSLAHALAHNTNLISLNLRL 371
           L    +  R     A  L  +  LR L LA+N++     +  L + L  N +L  L+LR 
Sbjct: 239 LENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRN 298

Query: 372 NCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHI 430
           N + D G   +   L +  K L TL L  N+L+      L   L    +L ++NL  N I
Sbjct: 299 NHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPI 358

Query: 431 GLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
           G +G + L  G+  N+++L   L  + +  E    + +
Sbjct: 359 GNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAE 396


>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 56/191 (29%), Positives = 88/191 (46%), Gaps = 3/191 (1%)

Query: 266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGA 324
           R  + LA A+K    L+   L  +K++  +    + +LL     L+ LDL  N + D G 
Sbjct: 247 RPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGL 306

Query: 325 RGAAKLLSHSR--LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQAL 382
               + L   R  L  L L NNQ+   G   L   L H  +L +LNL  N I +EG + L
Sbjct: 307 AYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366

Query: 383 AHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
            + L +N+ +  L L   +L+   A  +++ +A +  L  ++L  N I   G   L   +
Sbjct: 367 KNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426

Query: 443 SDNKTLLEFDL 453
             N +LL  DL
Sbjct: 427 KVNHSLLRLDL 437



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 4/218 (1%)

Query: 254 MNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELD 313
           +N  +N  + T R   + A  ++    L+      + + D  A  + R+L     L  L 
Sbjct: 180 LNISFNKHIGT-RGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 314 LSQNLIGDRGARGAAKLLS-HSRLRVLNLANNQVRA-PGAQSLAHALAHNTNLISLNLRL 371
           L    +  R     A  L  +  LR L LA+N++     +  L + L  N +L  L+LR 
Sbjct: 239 LENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRN 298

Query: 372 NCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHI 430
           N + D G   +   L +  K L TL L  N+L+      L   L    +L ++NL  N I
Sbjct: 299 NHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPI 358

Query: 431 GLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
           G +G + L  G+  N+++L   L  + +  E    + +
Sbjct: 359 GNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAE 396


>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 56/191 (29%), Positives = 88/191 (46%), Gaps = 3/191 (1%)

Query: 266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGA 324
           R  + LA A+K    L+   L  +K++  +    + +LL     L+ LDL  N + D G 
Sbjct: 247 RPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGL 306

Query: 325 RGAAKLLSHSR--LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQAL 382
               + L   R  L  L L NNQ+   G   L   L H  +L +LNL  N I +EG + L
Sbjct: 307 AYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366

Query: 383 AHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
            + L +N+ +  L L   +L+   A  +++ +A +  L  ++L  N I   G   L   +
Sbjct: 367 KNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426

Query: 443 SDNKTLLEFDL 453
             N +LL  DL
Sbjct: 427 KVNHSLLRLDL 437



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 4/218 (1%)

Query: 254 MNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELD 313
           +N  +N  + T R   + A  ++    L+      + + D  A  + R+L     L  L 
Sbjct: 180 LNISFNKHIGT-RGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 314 LSQNLIGDRGARGAAKLLS-HSRLRVLNLANNQVRA-PGAQSLAHALAHNTNLISLNLRL 371
           L    +  R     A  L  +  LR L LA+N++     +  L + L  N +L  L+LR 
Sbjct: 239 LENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRN 298

Query: 372 NCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHI 430
           N + D G   +   L +  K L TL L  N+L+      L   L    +L ++NL  N I
Sbjct: 299 NHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPI 358

Query: 431 GLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
           G +G + L  G+  N+++L   L  + +  E    + +
Sbjct: 359 GNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAE 396


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 52/160 (32%), Positives = 75/160 (46%), Gaps = 4/160 (2%)

Query: 299  IIRSLLDHPVLEELDLSQNLIGDRGARGAAKLL--SHSRLRVLNLANNQVRAPGAQSLAH 356
            I + L   P L+ L L+ N + D+G    +  L  S   L+ L L +  + A G QSLA 
Sbjct: 886  ISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLAS 945

Query: 357  ALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLA 415
            AL  N +L  L L  N + +EG   L  +++   C L  L L    L       L+  L 
Sbjct: 946  ALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALM 1005

Query: 416  INTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRL 455
             N+ LT ++LS N +  +G K L E M +    L+ DL L
Sbjct: 1006 GNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQ-DLEL 1044



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 42/148 (28%), Positives = 73/148 (49%), Gaps = 4/148 (2%)

Query: 306 HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTN 363
           HP L +LDL  +++ +R  +     L H   +++ L   N Q+  PG Q L   +  N N
Sbjct: 780 HPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQI-TPGVQHLWRIVMANRN 838

Query: 364 LISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTS 422
           L SLNL    +++E  +    AL+  KC L +L L    L+      +SQ+L  + +L S
Sbjct: 839 LRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKS 898

Query: 423 INLSCNHIGLDGGKQLLEGMSDNKTLLE 450
           ++L+ N +   G   L + +  ++  L+
Sbjct: 899 LSLAGNKVTDQGVMPLSDALRVSQCALQ 926



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 3/162 (1%)

Query: 280  TLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS--RLR 337
            +L+   L +  +D      +  +L+ +  L  L LS N + D G +   +++      L+
Sbjct: 981  SLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQ 1040

Query: 338  VLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHAL-QTNKCLTTLH 396
             L L    + A   +SL+  ++ + +L SL+L  N + D G  AL   L Q N  L  L 
Sbjct: 1041 DLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100

Query: 397  LGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQL 438
            L    L+      LS  L+ N  LTS+NL  N+    G  +L
Sbjct: 1101 LKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKL 1142



 Score = 36.2 bits (82), Expect = 0.071
 Identities = 32/122 (26%), Positives = 52/122 (42%), Gaps = 1/122 (0%)

Query: 307 PVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           PV+      + LI ++     + L +H  LR L+L ++ +     ++L   L H T  I 
Sbjct: 754 PVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQ 813

Query: 367 LNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLA-INTTLTSINL 425
             +  N     G Q L   +  N+ L +L+LGG  L E    +  + L      L S+ L
Sbjct: 814 TLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRL 873

Query: 426 SC 427
            C
Sbjct: 874 DC 875


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 50/160 (31%), Positives = 71/160 (44%), Gaps = 3/160 (1%)

Query: 286 LTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLAN 343
           L  S +     R +   L     L ELDLS N +GD G R   + L H    +R L L  
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779

Query: 344 NQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNEL 402
             +       ++  L+ N  L+ L+L  N + D G + L   L+   C L  L L  + L
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 839

Query: 403 SEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGM 442
           +    + LS VL+ N  LT + L  N +G  G K L EG+
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL 879



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/153 (32%), Positives = 72/153 (47%), Gaps = 4/153 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L ELDLS N +GD G R     L H    L+ L L N+ + +    +L+  L+ N NL  
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859

Query: 367 LNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L LR N + D+G + L   L    C L  L L    L+      LS +L  + +L  ++L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV 458
             N +G  G     E +     LL+ +L LS++
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQ-NLGLSEM 951


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 51/158 (32%), Positives = 73/158 (46%), Gaps = 16/158 (10%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSR---LRVLNLANNQVRAPGAQSLAHALAHNTNLI 365
           L ELDLS N  G  G +G   LL  S    L+ L L N  +   G + LA AL       
Sbjct: 114 LVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKS 173

Query: 366 S-----LNLRL-----NCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLA 415
           S     L L++     N +E++G  ALA A +    L  +H+  N ++ P  T L+Q  A
Sbjct: 174 SAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFA 233

Query: 416 INTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDL 453
           +N  L  INL+ N     G   + E +   KTL + ++
Sbjct: 234 VNPLLRVINLNDNTFTEKGAVAMAETL---KTLRQVEV 268



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 49/202 (24%), Positives = 81/202 (40%), Gaps = 38/202 (18%)

Query: 271 LAAAIKACH----------TLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIG 320
           LAAA+  CH           LK+F   R+++++D A  +  +      LEE+ + QN I 
Sbjct: 162 LAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGIN 221

Query: 321 DRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQ 380
                                       PG  +LA A A N  L  +NL  N   ++G  
Sbjct: 222 H---------------------------PGITALAQAFAVNPLLRVINLNDNTFTEKGAV 254

Query: 381 ALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAIN-TTLTSINLSCNHIGLDGGKQLL 439
           A+A  L+T + +  ++ G   +    A  ++  +      L  +NLS   I  D    + 
Sbjct: 255 AMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVA 314

Query: 440 EGMSDNKTLLEFDLRLSDVAQE 461
           E M+D   L + DL  + + +E
Sbjct: 315 EAMADKAELEKLDLNGNTLGEE 336



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 2/147 (1%)

Query: 270 SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
           +LA A +   TL+   + ++ ++      + ++   +P+L  ++L+ N   ++GA   A+
Sbjct: 199 ALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAE 258

Query: 330 LLSHSR-LRVLNLANNQVRAPGAQSLAHALAHNT-NLISLNLRLNCIEDEGGQALAHALQ 387
            L   R + V+N  +  VR+ GA ++A A+      L  LNL    I+ +   A+A A+ 
Sbjct: 259 TLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMA 318

Query: 388 TNKCLTTLHLGGNELSEPTATLLSQVL 414
               L  L L GN L E     L +VL
Sbjct: 319 DKAELEKLDLNGNTLGEEGCEQLQEVL 345



 Score = 35.8 bits (81), Expect = 0.093
 Identities = 28/120 (23%), Positives = 55/120 (45%), Gaps = 2/120 (1%)

Query: 270 SLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK 329
           +LA A      L++  L  +   +  A  +  +L     +E ++    L+  +GA   A 
Sbjct: 227 ALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIAD 286

Query: 330 LLSHS--RLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ 387
            +     +L+ LNL+  +++   A ++A A+A    L  L+L  N + +EG + L   L+
Sbjct: 287 AIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLE 346


>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
          Length = 975

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 6/174 (3%)

Query: 268 CLSLAAAI-KACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARG 326
           C  +AA +    H L    L   ++D    R ++   L      +L L  N +G    + 
Sbjct: 713 CTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLR---ARKLGLQLNSLGPEACKD 769

Query: 327 AAKLLSHSRLRV--LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAH 384
              LL H + ++  L L+NN + A G   L   LA NT++  L+L    + DEG + LA 
Sbjct: 770 LRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAA 829

Query: 385 ALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQL 438
            L  N+ L  L++  N   +  A  L++    + +L  ++L  N +  +G + L
Sbjct: 830 QLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/132 (25%), Positives = 63/132 (47%), Gaps = 4/132 (3%)

Query: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHL 397
           +NLA+ Q+   G ++L         L    L+LN +  E  + L   L  ++C +TTL L
Sbjct: 730 VNLASCQLDPAGLRTLLPVFLRARKL---GLQLNSLGPEACKDLRDLLLHDQCQITTLRL 786

Query: 398 GGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSD 457
             N L+     +L + LA NT++T ++L    +G +G + L   +  N+ L E ++  + 
Sbjct: 787 SNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNG 846

Query: 458 VAQESEYLIGQA 469
               +   + +A
Sbjct: 847 AGDTAALALARA 858



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 36/144 (25%), Positives = 58/144 (40%), Gaps = 5/144 (3%)

Query: 334 SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGG--QALAHALQTNKC 391
           S LR LNLA  ++       +A  L    + +      +C  D  G    L   L+  K 
Sbjct: 696 SSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKL 755

Query: 392 LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEF 451
              L+  G E  +    LL   L     +T++ LS N +   G   L+EG++ N ++   
Sbjct: 756 GLQLNSLGPEACKDLRDLL---LHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHL 812

Query: 452 DLRLSDVAQESEYLIGQALYANRE 475
            L  + +  E   L+   L  NR+
Sbjct: 813 SLLHTGLGDEGLELLAAQLDRNRQ 836


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/153 (32%), Positives = 72/153 (47%), Gaps = 4/153 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L ELDLS N +GD G R     L H    L+ L L N+ + +    +L+  L+ N NL  
Sbjct: 743 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 802

Query: 367 LNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L LR N + D+G + L   L    C L  L L    L+      LS +L  + +L  ++L
Sbjct: 803 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 862

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV 458
             N +G  G     E +     LL+ +L LS++
Sbjct: 863 GNNDLGDLGVMMFCEVLKQQSCLLQ-NLGLSEM 894


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 4/158 (2%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALAHNTNLIS 366
           L+EL L+ N +GD GAR   + L     +L  L + +    A      +  LA N  L+ 
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345

Query: 367 LNLRLNCIEDEGGQALAHAL-QTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINL 425
           L +  N +ED G + L   L Q    L  L L   ++S+ + + L+  L  N +L  ++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405

Query: 426 SCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463
           S N +G  G  QL+E +     LLE  L L D+    E
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLE-QLVLYDIYWSEE 442



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 45/213 (21%)

Query: 216 SEGEMEEPTVDHYQLGD-----LVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLS 270
           S+  + E  +   +LGD     L  GL H         + +CG+         T + C  
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI---------TAKGCGD 275

Query: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLD------------------------- 305
           L   ++A  +LK   L  +++ D+ AR++  +LL+                         
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 306 ----HPVLEELDLSQNLIGDRGARGAAKLLSH--SRLRVLNLANNQVRAPGAQSLAHALA 359
               +  L EL +S N + D G R   + L    S LRVL LA+  V      SLA  L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 360 HNTNLISLNLRLNCIEDEGGQALAHALQTNKCL 392
            N +L  L+L  NC+ D G   L  +++   CL
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCL 428



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 46/172 (26%), Positives = 75/172 (43%), Gaps = 3/172 (1%)

Query: 282 KIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVL 339
           ++ +L    + + + + I  +L  +P L EL+L  N +GD G     + L     +++ L
Sbjct: 31  QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90

Query: 340 NLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLG 398
           +L N  +   G   L+  L     L  L+L  N + D G Q L   L   +C L  L L 
Sbjct: 91  SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150

Query: 399 GNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
              LS  +   L+ VL        + +S N I   G + L +G+ D+   LE
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 298 IIIRSLLDHPVLEELDLSQNLIGDRGARGAAK--LLSHSRLRVLNLANNQVRAPGAQSLA 355
           ++  +L   P L+EL LS NL+GD G +   +  L    RL  L L    + A   + LA
Sbjct: 104 VLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163

Query: 356 HALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVL 414
             L    +   L +  N I + G + L   L+ + C L  L L    ++      L  ++
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIV 223

Query: 415 AINTTLTSINLSCNHIGLDGGKQLLEGM 442
           A   +L  + L  N +G  G  +L  G+
Sbjct: 224 ASKASLRELALGSNKLGDVGMAELCPGL 251



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 68/144 (47%), Gaps = 5/144 (3%)

Query: 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLN 368
           ++ LD+    + D  AR A  L    + +V+ L +  +     + ++ AL  N  L  LN
Sbjct: 5   IQSLDIQCEELSD--ARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELN 62

Query: 369 LRLNCIEDEGGQALAHALQTNKC-LTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSC 427
           LR N + D G   +   LQT  C +  L L    L+     +LS  L    TL  ++LS 
Sbjct: 63  LRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSD 122

Query: 428 NHIGLDGGKQLL-EGMSDNKTLLE 450
           N +G D G QLL EG+ D +  LE
Sbjct: 123 NLLG-DAGLQLLCEGLLDPQCRLE 145


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,619,320
Number of Sequences: 37866
Number of extensions: 900459
Number of successful extensions: 3883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 3457
Number of HSP's gapped (non-prelim): 326
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.