Search of human proteins with 226246618

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226246618 transforming, acidic coiled-coil containing
protein 1 isoform 3 [Homo sapiens]
         (610 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170763517 transforming, acidic coiled-coil containing protein...  1200   0.0  
gi|226246618 transforming, acidic coiled-coil containing protein...  1200   0.0  
gi|170763519 transforming, acidic coiled-coil containing protein...   664   0.0  
gi|45827753 transforming, acidic coiled-coil containing protein ...   306   3e-83
gi|150418009 transforming, acidic coiled-coil containing protein...   300   2e-81
gi|45827755 transforming, acidic coiled-coil containing protein ...   300   2e-81
gi|11119414 transforming, acidic coiled-coil containing protein ...   300   2e-81
gi|5454102 transforming, acidic coiled-coil containing protein 3...   234   2e-61
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]    56   8e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       55   1e-07
gi|71061468 centromere protein E [Homo sapiens]                        55   2e-07
gi|31982906 cingulin-like 1 [Homo sapiens]                             55   2e-07
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             54   3e-07
gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo sa...    54   3e-07
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         53   9e-07
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         53   9e-07
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]         53   9e-07
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         53   9e-07
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]         53   9e-07
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]         53   9e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     52   2e-06
gi|31542634 filamin A interacting protein 1 [Homo sapiens]             51   3e-06
gi|56550043 sarcolemma associated protein [Homo sapiens]               51   3e-06
gi|58530840 desmoplakin isoform I [Homo sapiens]                       51   4e-06
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    50   6e-06
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    50   6e-06
gi|23503243 Ras association (RalGDS/AF-6) domain family (N-termi...    50   6e-06
gi|225579095 S-phase cyclin A-associated protein in the ER isofo...    50   8e-06
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           50   8e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           50   8e-06

>gi|170763517 transforming, acidic coiled-coil containing protein 1
           isoform 1 [Homo sapiens]
          Length = 805

 Score = 1200 bits (3104), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 1   MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE 60
           MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE
Sbjct: 196 MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE 255

Query: 61  GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS 120
           GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS
Sbjct: 256 GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS 315

Query: 121 SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG 180
           SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG
Sbjct: 316 SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG 375

Query: 181 PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL 240
           PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL
Sbjct: 376 PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL 435

Query: 241 TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD 300
           TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD
Sbjct: 436 TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD 495

Query: 301 ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 360
           ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI
Sbjct: 496 ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 555

Query: 361 EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII 420
           EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII
Sbjct: 556 EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII 615

Query: 421 TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE 480
           TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE
Sbjct: 616 TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE 675

Query: 481 QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI 540
           QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI
Sbjct: 676 QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI 735

Query: 541 HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD 600
           HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD
Sbjct: 736 HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD 795

Query: 601 ELIAKLGKTD 610
           ELIAKLGKTD
Sbjct: 796 ELIAKLGKTD 805


>gi|226246618 transforming, acidic coiled-coil containing protein 1
           isoform 3 [Homo sapiens]
          Length = 610

 Score = 1200 bits (3104), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 1   MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE 60
           MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE
Sbjct: 1   MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVE 60

Query: 61  GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS 120
           GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS
Sbjct: 61  GTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS 120

Query: 121 SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG 180
           SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG
Sbjct: 121 SPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDG 180

Query: 181 PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL 240
           PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL
Sbjct: 181 PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTL 240

Query: 241 TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD 300
           TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD
Sbjct: 241 TSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISD 300

Query: 301 ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 360
           ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI
Sbjct: 301 ISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 360

Query: 361 EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII 420
           EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII
Sbjct: 361 EKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEII 420

Query: 421 TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE 480
           TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE
Sbjct: 421 TKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE 480

Query: 481 QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI 540
           QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI
Sbjct: 481 QALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI 540

Query: 541 HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD 600
           HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD
Sbjct: 541 HAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD 600

Query: 601 ELIAKLGKTD 610
           ELIAKLGKTD
Sbjct: 601 ELIAKLGKTD 610


>gi|170763519 transforming, acidic coiled-coil containing protein 1
           isoform 2 [Homo sapiens]
          Length = 395

 Score =  664 bits (1713), Expect = 0.0
 Identities = 347/363 (95%), Positives = 350/363 (96%), Gaps = 2/363 (0%)

Query: 248 PTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGH 307
           P G+   E  +S  + KS    SGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGH
Sbjct: 35  PEGDPEEE--DSQAETKSLSFRSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGH 92

Query: 308 ATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQK 367
           ATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQK
Sbjct: 93  ATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQK 152

Query: 368 MEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEAN 427
           MEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEAN
Sbjct: 153 MEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEAN 212

Query: 428 EWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN 487
           EWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN
Sbjct: 213 EWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLN 272

Query: 488 SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLD 547
           SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLD
Sbjct: 273 SVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLD 332

Query: 548 KANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLG 607
           KANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLG
Sbjct: 333 KANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLG 392

Query: 608 KTD 610
           KTD
Sbjct: 393 KTD 395


>gi|45827753 transforming, acidic coiled-coil containing protein 2
           isoform c [Homo sapiens]
          Length = 996

 Score =  306 bits (785), Expect = 3e-83
 Identities = 232/643 (36%), Positives = 324/643 (50%), Gaps = 79/643 (12%)

Query: 29  PSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP--KASYHFSPEELDE-NTSPLLG 85
           P  +  LR+PK     +K      S   +  E   +P  K +Y F  ++ D+ N +P   
Sbjct: 371 PVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 430

Query: 86  DARFQKSPPDLKETPGTLSSDTNDSGVE---LGEESRSSPLKLEFDFTEDTGNIEARKAL 142
            ++ Q+SP  L +       DT D  V+      ++ SSP K    F      +EA    
Sbjct: 431 TSKMQESPK-LPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVD 489

Query: 143 PRKLGRKLGSTLTP-KIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNP 201
              L +      TP K     + KS      +DP ++D   + T         E+P    
Sbjct: 490 GDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATP--------ETPPVIS 541

Query: 202 FGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPT---TTLTSSDFCSPT--------- 249
              H+  +    ++++       D   +  D  +P+   T +  + F SPT         
Sbjct: 542 AVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSY 601

Query: 250 --------GNHVNEILESPKKAKSRLI-------------------TSGCKVKKHETQSL 282
                   G+ + +  ++PKK    L+                    + C     E    
Sbjct: 602 EIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEA 661

Query: 283 ALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY---- 338
            ++  ++++  V   ++   N++ H    EK +     QK   A   G P E +E     
Sbjct: 662 LVNTAAKNQHPVPRGLAP--NQESHLQVPEKSS-----QKELEAMGLGTPSEAIEITAPE 714

Query: 339 --FECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGG-- 394
             F  ++  +S + H  S   A    E     +        L   +A    VS+S     
Sbjct: 715 GSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQREAAHPTDVSISKTALY 774

Query: 395 --------ESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKI 446
                   E P  G+   + D  + L + R EIITKE E +EWK KYEE+R+EV+EMRKI
Sbjct: 775 SRIGTAEVEKPA-GLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKI 833

Query: 447 VAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGV 506
           VAEYEKTIAQMIEDEQR    S ++ QQL +EKEQALADLNSVE+SL+DLFRRYE +K V
Sbjct: 834 VAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEV 893

Query: 507 LEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAA 566
           LEGF+KNEE LK+CAQ+YL+RVK+EEQRYQALK+HAEEKLD+AN EIAQVR KA+ E AA
Sbjct: 894 LEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAA 953

Query: 567 LHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKT 609
             A LRKEQ++V++LER L+QKN+EIEELTKICDELIAK+GK+
Sbjct: 954 HQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS 996



 Score =  112 bits (279), Expect = 1e-24
 Identities = 112/383 (29%), Positives = 183/383 (47%), Gaps = 54/383 (14%)

Query: 57  AAVEGTPL-----PKASYHFSPEELDENTSPLLGDARFQKSPPDLKET-PGTLSSDT--- 107
           A +E TPL     PKA+     E  +    P  G  R Q SPP  ++T P T + +    
Sbjct: 264 ALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEV 323

Query: 108 --NDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALP---RKLGRKLGSTLT---PKIQ 159
             +DSG +    ++   ++LEFD++ED  + + ++  P   +K+G+K  + +    PK++
Sbjct: 324 TPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMK 383

Query: 160 KD----GISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLS 215
           K       + ++    P +P   D P+++ +   D  +W+ P+FNPF S S +Q SP L 
Sbjct: 384 KTPEKLDNTPASPPRSPAEP--NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLP 441

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHV-----------NEILESP-KKA 263
            + SY+FDPD  DES+DPFK ++   SS   SP    +            + L  P KK 
Sbjct: 442 QQ-SYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKK 500

Query: 264 KSRLITSGCKVKKHETQSLALDACSRD-EGAVISQISDISNRDGHATDEEKLASTSCGQK 322
           K+ L T   +VKK   +S   D  S+D   A   +   + +   HATDEEKLA T+  QK
Sbjct: 501 KTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTN--QK 558

Query: 323 SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKET---CQKMEEDGSTV---- 375
                V  E ++  +Y + S++        FSS    ++       + ME+ GS++    
Sbjct: 559 WTCMTVDLEADKQ-DYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDD 617

Query: 376 -------LGLLESSAEKAPVSVS 391
                  L L+  +++++PV  S
Sbjct: 618 DAPKKQALYLMFDTSQESPVKSS 640



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 11/119 (9%)

Query: 117 ESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPV 176
           E+ SS  +  F+  E T  ++A  A P      +     P++      +  G    T PV
Sbjct: 21  EAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPEEPGCGSETVPV 77

Query: 177 ARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFK 235
             DGP S  S +  P +  S SF+     +V     P++S G+Y+ D DN  E +D F+
Sbjct: 78  P-DGPRSD-SVEGSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFDNI-ELVDTFQ 128


>gi|150418009 transforming, acidic coiled-coil containing protein 2
            isoform a [Homo sapiens]
          Length = 2948

 Score =  300 bits (769), Expect = 2e-81
 Identities = 237/676 (35%), Positives = 336/676 (49%), Gaps = 115/676 (17%)

Query: 29   PSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP--KASYHFSPEELDE-NTSPLLG 85
            P  +  LR+PK     +K      S   +  E   +P  K +Y F  ++ D+ N +P   
Sbjct: 2293 PVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 2352

Query: 86   DARFQKSPPDLKETPGTLSSDTNDSGVE---LGEESRSSPLKLEFDFTEDTGNIEARKAL 142
             ++ Q+SP  L +       DT D  V+      ++ SSP K    F      +EA    
Sbjct: 2353 TSKMQESPK-LPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVD 2411

Query: 143  PRKLGRKLGSTLTP-KIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNP 201
               L +      TP K     + KS           +  PLS   S+ DP+   +P   P
Sbjct: 2412 GDGLNKPAKKKKTPLKTDTFRVKKSP----------KRSPLSDPPSQ-DPTPAATPETPP 2460

Query: 202  FGS---HSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPT---TTLTSSDFCSPT------ 249
              S   H+  +    ++++       D   +  D  +P+   T +  + F SPT      
Sbjct: 2461 VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 2520

Query: 250  -----------GNHVNEILESPKKAKSRLI-------------------TSGCKVKKHET 279
                       G+ + +  ++PKK    L+                    + C     E 
Sbjct: 2521 NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 2580

Query: 280  QSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY- 338
                ++  ++++  V   ++   N++ H    EK +     QK   A   G P E +E  
Sbjct: 2581 TEALVNTAAKNQHPVPRGLAP--NQESHLQVPEKSS-----QKELEAMGLGTPSEAIEIT 2633

Query: 339  -----FECSNVPVSTINH------AFSSSEAGIEKET----CQKMEEDGSTVLGLLES-- 381
                 F  ++  +S + H      A    E  + ++      QK++E+    +  +E+  
Sbjct: 2634 APEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALK 2693

Query: 382  ------------------SAEKAPVSVSCGG----------ESPLDGICLSESDKTAVLT 413
                              +A    VS+S             E P  G+   + D  + L 
Sbjct: 2694 LARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPA-GLLFQQPDLDSALQ 2752

Query: 414  LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473
            + R EIITKE E +EWK KYEE+R+EV+EMRKIVAEYEKTIAQMIEDEQR    S ++ Q
Sbjct: 2753 IARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQ 2812

Query: 474  QLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQ 533
            QL +EKEQALADLNSVE+SL+DLFRRYE +K VLEGF+KNEE LK+CAQ+YL+RVK+EEQ
Sbjct: 2813 QLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQ 2872

Query: 534  RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIE 593
            RYQALK+HAEEKLD+AN EIAQVR KA+ E AA  A LRKEQ++V++LER L+QKN+EIE
Sbjct: 2873 RYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIE 2932

Query: 594  ELTKICDELIAKLGKT 609
            ELTKICDELIAK+GK+
Sbjct: 2933 ELTKICDELIAKMGKS 2948



 Score =  112 bits (279), Expect = 1e-24
 Identities = 112/383 (29%), Positives = 183/383 (47%), Gaps = 54/383 (14%)

Query: 57   AAVEGTPL-----PKASYHFSPEELDENTSPLLGDARFQKSPPDLKET-PGTLSSDT--- 107
            A +E TPL     PKA+     E  +    P  G  R Q SPP  ++T P T + +    
Sbjct: 2186 ALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEV 2245

Query: 108  --NDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALP---RKLGRKLGSTLT---PKIQ 159
              +DSG +    ++   ++LEFD++ED  + + ++  P   +K+G+K  + +    PK++
Sbjct: 2246 TPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMK 2305

Query: 160  KD----GISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLS 215
            K       + ++    P +P   D P+++ +   D  +W+ P+FNPF S S +Q SP L 
Sbjct: 2306 KTPEKLDNTPASPPRSPAEP--NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLP 2363

Query: 216  SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHV-----------NEILESP-KKA 263
             + SY+FDPD  DES+DPFK ++   SS   SP    +            + L  P KK 
Sbjct: 2364 QQ-SYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKK 2422

Query: 264  KSRLITSGCKVKKHETQSLALDACSRD-EGAVISQISDISNRDGHATDEEKLASTSCGQK 322
            K+ L T   +VKK   +S   D  S+D   A   +   + +   HATDEEKLA T+  QK
Sbjct: 2423 KTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTN--QK 2480

Query: 323  SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKET---CQKMEEDGSTV---- 375
                 V  E ++  +Y + S++        FSS    ++       + ME+ GS++    
Sbjct: 2481 WTCMTVDLEADKQ-DYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDD 2539

Query: 376  -------LGLLESSAEKAPVSVS 391
                   L L+  +++++PV  S
Sbjct: 2540 DAPKKQALYLMFDTSQESPVKSS 2562



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 22/190 (11%)

Query: 57   AAVEGTPLPKASYH------FSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDS 110
            A +E   L  +SYH       S + + ++ SP    A    S  +   +P   + D  ++
Sbjct: 1872 ADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEA 1931

Query: 111  GVELGEE-----SRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISK 165
                  +     SRSS  +  F+  E T  ++A  A P      +     P++      +
Sbjct: 1932 STPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPE 1988

Query: 166  SAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPD 225
              G    T PV  DGP S  S +  P +  S SF+     +V     P++S G+Y+ D D
Sbjct: 1989 EPGCGSETVPVP-DGPRSD-SVEGSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFD 2041

Query: 226  NFDESMDPFK 235
            N  E +D F+
Sbjct: 2042 NI-ELVDTFQ 2050


>gi|45827755 transforming, acidic coiled-coil containing protein 2
            isoform b [Homo sapiens]
          Length = 1094

 Score =  300 bits (769), Expect = 2e-81
 Identities = 237/676 (35%), Positives = 336/676 (49%), Gaps = 115/676 (17%)

Query: 29   PSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP--KASYHFSPEELDE-NTSPLLG 85
            P  +  LR+PK     +K      S   +  E   +P  K +Y F  ++ D+ N +P   
Sbjct: 439  PVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 498

Query: 86   DARFQKSPPDLKETPGTLSSDTNDSGVE---LGEESRSSPLKLEFDFTEDTGNIEARKAL 142
             ++ Q+SP  L +       DT D  V+      ++ SSP K    F      +EA    
Sbjct: 499  TSKMQESPK-LPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVD 557

Query: 143  PRKLGRKLGSTLTP-KIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNP 201
               L +      TP K     + KS           +  PLS   S+ DP+   +P   P
Sbjct: 558  GDGLNKPAKKKKTPLKTDTFRVKKSP----------KRSPLSDPPSQ-DPTPAATPETPP 606

Query: 202  FGS---HSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPT---TTLTSSDFCSPT------ 249
              S   H+  +    ++++       D   +  D  +P+   T +  + F SPT      
Sbjct: 607  VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 666

Query: 250  -----------GNHVNEILESPKKAKSRLI-------------------TSGCKVKKHET 279
                       G+ + +  ++PKK    L+                    + C     E 
Sbjct: 667  NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 726

Query: 280  QSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY- 338
                ++  ++++  V   ++   N++ H    EK +     QK   A   G P E +E  
Sbjct: 727  TEALVNTAAKNQHPVPRGLAP--NQESHLQVPEKSS-----QKELEAMGLGTPSEAIEIT 779

Query: 339  -----FECSNVPVSTINH------AFSSSEAGIEKET----CQKMEEDGSTVLGLLES-- 381
                 F  ++  +S + H      A    E  + ++      QK++E+    +  +E+  
Sbjct: 780  APEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALK 839

Query: 382  ------------------SAEKAPVSVSCGG----------ESPLDGICLSESDKTAVLT 413
                              +A    VS+S             E P  G+   + D  + L 
Sbjct: 840  LARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPA-GLLFQQPDLDSALQ 898

Query: 414  LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473
            + R EIITKE E +EWK KYEE+R+EV+EMRKIVAEYEKTIAQMIEDEQR    S ++ Q
Sbjct: 899  IARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQ 958

Query: 474  QLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQ 533
            QL +EKEQALADLNSVE+SL+DLFRRYE +K VLEGF+KNEE LK+CAQ+YL+RVK+EEQ
Sbjct: 959  QLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQ 1018

Query: 534  RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIE 593
            RYQALK+HAEEKLD+AN EIAQVR KA+ E AA  A LRKEQ++V++LER L+QKN+EIE
Sbjct: 1019 RYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIE 1078

Query: 594  ELTKICDELIAKLGKT 609
            ELTKICDELIAK+GK+
Sbjct: 1079 ELTKICDELIAKMGKS 1094



 Score =  112 bits (279), Expect = 1e-24
 Identities = 112/383 (29%), Positives = 183/383 (47%), Gaps = 54/383 (14%)

Query: 57  AAVEGTPL-----PKASYHFSPEELDENTSPLLGDARFQKSPPDLKET-PGTLSSDT--- 107
           A +E TPL     PKA+     E  +    P  G  R Q SPP  ++T P T + +    
Sbjct: 332 ALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEV 391

Query: 108 --NDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALP---RKLGRKLGSTLT---PKIQ 159
             +DSG +    ++   ++LEFD++ED  + + ++  P   +K+G+K  + +    PK++
Sbjct: 392 TPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMK 451

Query: 160 KD----GISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLS 215
           K       + ++    P +P   D P+++ +   D  +W+ P+FNPF S S +Q SP L 
Sbjct: 452 KTPEKLDNTPASPPRSPAEP--NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLP 509

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHV-----------NEILESP-KKA 263
            + SY+FDPD  DES+DPFK ++   SS   SP    +            + L  P KK 
Sbjct: 510 QQ-SYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKK 568

Query: 264 KSRLITSGCKVKKHETQSLALDACSRD-EGAVISQISDISNRDGHATDEEKLASTSCGQK 322
           K+ L T   +VKK   +S   D  S+D   A   +   + +   HATDEEKLA T+  QK
Sbjct: 569 KTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTN--QK 626

Query: 323 SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKET---CQKMEEDGSTV---- 375
                V  E ++  +Y + S++        FSS    ++       + ME+ GS++    
Sbjct: 627 WTCMTVDLEADKQ-DYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDD 685

Query: 376 -------LGLLESSAEKAPVSVS 391
                  L L+  +++++PV  S
Sbjct: 686 DAPKKQALYLMFDTSQESPVKSS 708



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 46/167 (27%), Positives = 73/167 (43%), Gaps = 14/167 (8%)

Query: 72  SPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEE---SRSSPLKLEFD 128
           SP+  D ++SP+  D     +P DL+      SS   D   ++  +    RSS  +  F+
Sbjct: 41  SPDHRDASSSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQRSSDSEEAFE 100

Query: 129 FTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSK 188
             E T  ++A  A P      +     P++      +  G    T PV  DGP S  S +
Sbjct: 101 TPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPEEPGCGSETVPVP-DGPRSD-SVE 155

Query: 189 PDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFK 235
             P +  S SF+     +V     P++S G+Y+ D DN  E +D F+
Sbjct: 156 GSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFDNI-ELVDTFQ 196


>gi|11119414 transforming, acidic coiled-coil containing protein 2
            isoform d [Homo sapiens]
          Length = 1026

 Score =  300 bits (769), Expect = 2e-81
 Identities = 237/676 (35%), Positives = 336/676 (49%), Gaps = 115/676 (17%)

Query: 29   PSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLP--KASYHFSPEELDE-NTSPLLG 85
            P  +  LR+PK     +K      S   +  E   +P  K +Y F  ++ D+ N +P   
Sbjct: 371  PVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSS 430

Query: 86   DARFQKSPPDLKETPGTLSSDTNDSGVE---LGEESRSSPLKLEFDFTEDTGNIEARKAL 142
             ++ Q+SP  L +       DT D  V+      ++ SSP K    F      +EA    
Sbjct: 431  TSKMQESPK-LPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVD 489

Query: 143  PRKLGRKLGSTLTP-KIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNP 201
               L +      TP K     + KS           +  PLS   S+ DP+   +P   P
Sbjct: 490  GDGLNKPAKKKKTPLKTDTFRVKKSP----------KRSPLSDPPSQ-DPTPAATPETPP 538

Query: 202  FGS---HSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPT---TTLTSSDFCSPT------ 249
              S   H+  +    ++++       D   +  D  +P+   T +  + F SPT      
Sbjct: 539  VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR 598

Query: 250  -----------GNHVNEILESPKKAKSRLI-------------------TSGCKVKKHET 279
                       G+ + +  ++PKK    L+                    + C     E 
Sbjct: 599  NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE 658

Query: 280  QSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEY- 338
                ++  ++++  V   ++   N++ H    EK +     QK   A   G P E +E  
Sbjct: 659  TEALVNTAAKNQHPVPRGLAP--NQESHLQVPEKSS-----QKELEAMGLGTPSEAIEIT 711

Query: 339  -----FECSNVPVSTINH------AFSSSEAGIEKET----CQKMEEDGSTVLGLLES-- 381
                 F  ++  +S + H      A    E  + ++      QK++E+    +  +E+  
Sbjct: 712  APEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALK 771

Query: 382  ------------------SAEKAPVSVSCGG----------ESPLDGICLSESDKTAVLT 413
                              +A    VS+S             E P  G+   + D  + L 
Sbjct: 772  LARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPA-GLLFQQPDLDSALQ 830

Query: 414  LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473
            + R EIITKE E +EWK KYEE+R+EV+EMRKIVAEYEKTIAQMIEDEQR    S ++ Q
Sbjct: 831  IARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQ 890

Query: 474  QLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQ 533
            QL +EKEQALADLNSVE+SL+DLFRRYE +K VLEGF+KNEE LK+CAQ+YL+RVK+EEQ
Sbjct: 891  QLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQ 950

Query: 534  RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIE 593
            RYQALK+HAEEKLD+AN EIAQVR KA+ E AA  A LRKEQ++V++LER L+QKN+EIE
Sbjct: 951  RYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIE 1010

Query: 594  ELTKICDELIAKLGKT 609
            ELTKICDELIAK+GK+
Sbjct: 1011 ELTKICDELIAKMGKS 1026



 Score =  112 bits (279), Expect = 1e-24
 Identities = 112/383 (29%), Positives = 183/383 (47%), Gaps = 54/383 (14%)

Query: 57  AAVEGTPL-----PKASYHFSPEELDENTSPLLGDARFQKSPPDLKET-PGTLSSDT--- 107
           A +E TPL     PKA+     E  +    P  G  R Q SPP  ++T P T + +    
Sbjct: 264 ALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEV 323

Query: 108 --NDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALP---RKLGRKLGSTLT---PKIQ 159
             +DSG +    ++   ++LEFD++ED  + + ++  P   +K+G+K  + +    PK++
Sbjct: 324 TPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMK 383

Query: 160 KD----GISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLS 215
           K       + ++    P +P   D P+++ +   D  +W+ P+FNPF S S +Q SP L 
Sbjct: 384 KTPEKLDNTPASPPRSPAEP--NDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLP 441

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHV-----------NEILESP-KKA 263
            + SY+FDPD  DES+DPFK ++   SS   SP    +            + L  P KK 
Sbjct: 442 QQ-SYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKK 500

Query: 264 KSRLITSGCKVKKHETQSLALDACSRD-EGAVISQISDISNRDGHATDEEKLASTSCGQK 322
           K+ L T   +VKK   +S   D  S+D   A   +   + +   HATDEEKLA T+  QK
Sbjct: 501 KTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTN--QK 558

Query: 323 SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKET---CQKMEEDGSTV---- 375
                V  E ++  +Y + S++        FSS    ++       + ME+ GS++    
Sbjct: 559 WTCMTVDLEADKQ-DYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDD 617

Query: 376 -------LGLLESSAEKAPVSVS 391
                  L L+  +++++PV  S
Sbjct: 618 DAPKKQALYLMFDTSQESPVKSS 640



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 11/119 (9%)

Query: 117 ESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPV 176
           E+ SS  +  F+  E T  ++A  A P      +     P++      +  G    T PV
Sbjct: 21  EAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPE---PEVSTQPPPEEPGCGSETVPV 77

Query: 177 ARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFK 235
             DGP S  S +  P +  S SF+     +V     P++S G+Y+ D DN  E +D F+
Sbjct: 78  P-DGPRSD-SVEGSPFRPPSHSFS-----AVFDEDKPIASSGTYNLDFDNI-ELVDTFQ 128


>gi|5454102 transforming, acidic coiled-coil containing protein 3
           [Homo sapiens]
          Length = 838

 Score =  234 bits (597), Expect = 2e-61
 Identities = 180/549 (32%), Positives = 273/549 (49%), Gaps = 68/549 (12%)

Query: 102 TLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKD 161
           TLS     +  ++   SRS P+KLEFD ++  G    R   PR+LG + G  L P ++K 
Sbjct: 315 TLSPQEEVAAGQMASSSRSGPVKLEFDVSD--GATSKRAPPPRRLGERSG--LKPPLRKA 370

Query: 162 GISKSAGLEQPTDPVARDG-------PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPL 214
            + +    ++  +   R G       P S+ S   D  + + P+F PFG  +        
Sbjct: 371 AVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDT-------- 422

Query: 215 SSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKV 274
              G     P    E+         L +       G  +++ L S     + ++    + 
Sbjct: 423 -KSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAET 481

Query: 275 KKHETQSLALDACS---------------RDEGAVISQISDISNRD-------GHATDEE 312
              E++  AL++ S                 +G    ++ + S RD       G   D  
Sbjct: 482 PTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYL 541

Query: 313 KLASTSCGQKSA----GAEVKGEPEEDLEYFECSNVPVSTIN---HAFSSSEAGIEKETC 365
           +   TS  ++SA       +K +P   L       VPV+T     H  + + +G  +E  
Sbjct: 542 EQFGTSSFKESALRKQSLYLKFDPL--LRDSPGRPVPVATETSSMHGANETPSGRPREA- 598

Query: 366 QKMEEDGSTVLGLLESSAEKAPVSVSCGGESPL------DGICLSESDKTAVLTLIREEI 419
           + +E D    LG L+      P  V   G  PL      D +  S+ D  AV+   +EE 
Sbjct: 599 KLVEFD---FLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEE- 654

Query: 420 ITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEK 479
                   E + + EE   + LE+ KI+  +E+ + Q +E+ Q+    S+   Q++  EK
Sbjct: 655 ------NRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEK 708

Query: 480 EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALK 539
           +Q   DLNS+E+S SDLF+R+E  K V+EG++KNEE+LKKC +DYLAR+ QE QRYQALK
Sbjct: 709 DQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALK 768

Query: 540 IHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKIC 599
            HAEEKL  ANEEIAQVR+KA+AE+ AL A LRKEQM+++SLE+ ++QK +E EELT+IC
Sbjct: 769 AHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRIC 828

Query: 600 DELIAKLGK 608
           D+LI+K+ K
Sbjct: 829 DDLISKMEK 837



 Score = 32.7 bits (73), Expect = 1.00
 Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 15/144 (10%)

Query: 15  EADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIG--------GEFSDTNAAVEGTPLP- 65
           E D+  G +     P RR   R     PLRK A+          E    + A E  P+P 
Sbjct: 339 EFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPA 398

Query: 66  -KASYHFSPEELDE-NTSPLLGDAR---FQKSPPDLKETP-GTLSSDTNDSGVELGEESR 119
            + SYH   +++D+ N  P  GD +    +  PP+  ET  G  +++   +G    E   
Sbjct: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458

Query: 120 SSPLKLEFDFTEDTGNIEARKALP 143
               +L     EDT  ++     P
Sbjct: 459 CLSQQLHSASAEDTPVVQLAAETP 482


>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
          Length = 1233

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 49/206 (23%), Positives = 102/206 (49%), Gaps = 23/206 (11%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDE--QRTSMTSQKSF 472
           + +E+ +K  E  + KK+ ++   E+ E +K + +  +   Q IE E  ++ S  +QK  
Sbjct: 238 LNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE-QQQIEKEIKEKDSELNQKRP 296

Query: 473 QQLTMEKEQA--LADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQ 530
           Q +  ++  +  +  L + ++SL +  + Y+  KG ++  +K   +++K  Q++  R+++
Sbjct: 297 QYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEE 356

Query: 531 EEQ--------------RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQM 576
           E Q              +Y  LK  A ++     +E+ +     KA+   L     +E+ 
Sbjct: 357 ESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDL---EERK 413

Query: 577 KVESLERALQQKNQEIEELTKICDEL 602
           KVE+ E  ++QK +EIEE  K  ++L
Sbjct: 414 KVET-EAKIKQKLREIEENQKRIEKL 438



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 45/197 (22%), Positives = 80/197 (40%), Gaps = 43/197 (21%)

Query: 406 SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTS 465
           S K   L   ++ +   +    + K   +E  +E+L + K   E+          E+R  
Sbjct: 306 SHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF----------EERME 355

Query: 466 MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYL 525
             SQ   + LT+E+ Q                ++Y  LK         EEA K+      
Sbjct: 356 EESQSQGRDLTLEENQV---------------KKYHRLK---------EEASKRA----- 386

Query: 526 ARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERAL 585
           A + QE +++   +   +++LD   EE  +V T+AK +       + + Q ++E LE  +
Sbjct: 387 ATLAQELEKFNRDQKADQDRLDL--EERKKVETEAKIKQKLRE--IEENQKRIEKLEEYI 442

Query: 586 QQKNQEIEELTKICDEL 602
               Q +EE  K+  EL
Sbjct: 443 TTSKQSLEEQKKLEGEL 459



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 39/196 (19%), Positives = 84/196 (42%), Gaps = 35/196 (17%)

Query: 405 ESDKTAVLTLIREEIITK-EIEANEWKKKYEETR--QEVLEMRKIVAEYEKTIAQMIEDE 461
           E +K  +L   R  ++ +  +E+   K   E T   +E+    ++  EY+K   +M++ E
Sbjct: 120 ELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAE 179

Query: 462 QRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCA 521
           + T     +  + +  E+++A  +    +R        Y+ LK                 
Sbjct: 180 EDTQFNYHRK-KNIAAERKEAKQEKEEADR--------YQRLK----------------- 213

Query: 522 QDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVR---TKAKAESAALHAGLRKEQMKV 578
            D + R + + Q ++    H E +++K N+E+A       K K     +   L++++ ++
Sbjct: 214 -DEVVRAQVQLQLFKLY--HNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKEL 270

Query: 579 ESLERALQQKNQEIEE 594
             + R  QQ  +EI+E
Sbjct: 271 GKMMREQQQIEKEIKE 286


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 44/198 (22%), Positives = 100/198 (50%), Gaps = 10/198 (5%)

Query: 415  IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
            ++++I   E+   + +K+   T  +V  + + +A  ++ IA++ ++++      Q++   
Sbjct: 952  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1011

Query: 475  LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQR 534
            L +E+++    +NS+ +S   L ++ ++L+G LE  KK    L++  +     +K  ++ 
Sbjct: 1012 LQVEEDK----VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067

Query: 535  YQAL---KIHAEEKLDKANEEIAQVRTKAKAE---SAALHAGLRKEQMKVESLERALQQK 588
               L   K+  EEKL K   +I Q  +K + E   +  L   L++ Q ++E LE  L+ +
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127

Query: 589  NQEIEELTKICDELIAKL 606
                 ++ K+  +L  +L
Sbjct: 1128 RTARAKVEKLRSDLSREL 1145



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 122/594 (20%), Positives = 226/594 (38%), Gaps = 88/594 (14%)

Query: 75   ELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRS------SPLKLEFD 128
            ELD+ TS +    +  K+  +L++   TL    N+  V+L E  RS         KL+ +
Sbjct: 1229 ELDDVTSNM---EQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285

Query: 129  FTEDTGNIEARKALPRKLGR-KLGST-----LTPKIQKDGISKSAGLEQPTDPVARDGPL 182
              E    +E ++AL  +L R KL  T     L  +++++G +K+A L         D  L
Sbjct: 1286 NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA-LAHALQSARHDCDL 1344

Query: 183  SQTSSKPDPSQWESPSFNPFGSHSVLQ--NSPPLSSEGSYHFDPDNFDESMDPFKPTTTL 240
             +        Q+E  +        VL   NS        Y  D     E ++  K     
Sbjct: 1345 LR-------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1397

Query: 241  TSSDFCSPTGNHVNEILESPKKAKSRLITS----GCKVKKHETQSLALDACSRDEGAVIS 296
               D        VN    S +K K RL          V++    + ALD   R+   +++
Sbjct: 1398 RLQD-AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1456

Query: 297  QISDISNRDGHATDEEKLASTSCGQKSAGAEV---KGEPEEDLEYFECSNVPVSTINHAF 353
            +      +  +   + +L S+    +S   E+   K   EE LE+ E        +    
Sbjct: 1457 EW-----KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1511

Query: 354  SS-----SEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDK 408
            S       E G      +K+ +        L+S+ E+A  S+    E     I  ++ + 
Sbjct: 1512 SDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL----EHEEGKILRAQLEF 1567

Query: 409  TAVLTLIREEIITKEIEANEWKKKYEE--------------TRQEVLEMRKIVAEYEKTI 454
              +   I  ++  K+ E  + K+ ++               +R EVL ++K +      +
Sbjct: 1568 NQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEM 1627

Query: 455  AQMIEDEQRTSMTSQK---SFQQLTMEKEQALAD-----------LNSVERSLSDLFRRY 500
               +    R +  +QK   S Q L  + +  L D           +  VER  + L    
Sbjct: 1628 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1687

Query: 501  ENLKGVLEGFKKNEEALKKCAQDYLARVK----------QEEQRYQALKIHAEEKLDKAN 550
            E L+ V+E  +++ +  ++   +   RV+           ++++ ++     + ++++A 
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747

Query: 551  EEIAQVRTKAK---AESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDE 601
            +E      KAK    ++A +   L+KEQ     LER  +   Q I++L    DE
Sbjct: 1748 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 96/418 (22%), Positives = 175/418 (41%), Gaps = 77/418 (18%)

Query: 257  LESPKKAKSRLITSGCKVKKHETQSLA-LDACSRDEGAVISQISDISNRDG----HATDE 311
            LES +K    L T   K+K    +SL  L+   R+   +  +ISD++ + G    +  + 
Sbjct: 1469 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528

Query: 312  EKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEE- 370
            EK+      +K        E E  LE+ E     +      F+  +A IE++  +K EE 
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGK---ILRAQLEFNQIKAEIERKLAEKDEEM 1585

Query: 371  -----DGSTVLGLLESSA--------EKAPVSVSCGGESPLDGICLSESDKTA------- 410
                 +   V+  L++S         E   V     G+     I LS +++ A       
Sbjct: 1586 EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1645

Query: 411  --VLTLIREEIITKE--IEANEWKKK---YEETRQEVL-----EMRKIVAEYEKTIA--- 455
              + +L+++  I  +  + AN+  K+     E R  +L     E+R +V + E++     
Sbjct: 1646 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1705

Query: 456  -QMIEDEQR--------TSMTSQKS-----FQQLTMEKEQALADLNSVE----RSLSDLF 497
             ++IE  +R        TS+ +QK        QL  E E+A+ +  + E    ++++D  
Sbjct: 1706 QELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA 1765

Query: 498  RRYENLK------GVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANE 551
               E LK        LE  KKN E   K  Q  L     +E    ALK   +++L K   
Sbjct: 1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL-----DEAEQIALK-GGKKQLQKLEA 1819

Query: 552  EIAQVRTKAKAE---SAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             + ++  + +AE   +A    G+RK + +++ L    ++  + +  L  + D+L  K+
Sbjct: 1820 RVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKV 1877



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/194 (21%), Positives = 85/194 (43%), Gaps = 33/194 (17%)

Query: 428  EWKKKYEETRQEV-----------LEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLT 476
            EWK+KYEE++ E+            E+ K+   YE+++ + +E  +R +   Q+    LT
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL-EHLETFKRENKNLQEEISDLT 1515

Query: 477  MEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQ 536
             +  +   +++ +E+    L      L+  LE      EA  +  +  + R + E   + 
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALE----EAEASLEHEEGKILRAQLE---FN 1568

Query: 537  ALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELT 596
             +K   E KL + +EE+ Q +              R  Q  V+SL+ +L  + +   E+ 
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAK--------------RNHQRVVDSLQTSLDAETRSRNEVL 1614

Query: 597  KICDELIAKLGKTD 610
            ++  ++   L + +
Sbjct: 1615 RVKKKMEGDLNEME 1628



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 71/361 (19%), Positives = 139/361 (38%), Gaps = 53/361 (14%)

Query: 253  VNEILESPKK------AKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDG 306
            +NE LE  ++      AK R +   C   K +   L L     ++    ++ + + N   
Sbjct: 924  MNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE-NKVKNLTE 982

Query: 307  HATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVST----INHAFSSSEAGIEK 362
                 +++ +    +K A  E   +  +DL+  E     +S     +       E  +E+
Sbjct: 983  EMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQ 1042

Query: 363  ETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITK 422
            E   +M+         LE +  K    +    ES +D     E+DK      + E++  K
Sbjct: 1043 EKKVRMD---------LERAKRKLEGDLKLTQESIMD----LENDKLQ----LEEKLKKK 1085

Query: 423  EIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQA 482
            E + N+   K E+ +   L+++K + E +  I ++ E+E     T++             
Sbjct: 1086 EFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL-EEELEAERTARAK----------- 1133

Query: 483  LADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHA 542
                  VE+  SDL R  E +       ++ EEA        +   K+ E  +Q ++   
Sbjct: 1134 ------VEKLRSDLSRELEEIS------ERLEEA-GGATSVQIEMNKKREAEFQKMRRDL 1180

Query: 543  EEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDEL 602
            EE   +     A +R K     A L   +   Q   + LE+   +   E++++T   +++
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240

Query: 603  I 603
            I
Sbjct: 1241 I 1241



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 39/185 (21%)

Query: 432 KYEETRQEVLEMR----KIVAEYEKTIAQMIE-DEQRTSMTSQKSFQQLTMEKEQALADL 486
           K  ET +E+  M+    +I    EK+ A+  E +E+  S+  +K+  QL ++ EQ   +L
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD--NL 900

Query: 487 NSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKL 546
           N  E     L +    L+                     A+VK+  +R         E  
Sbjct: 901 NDAEERCDQLIKNKIQLE---------------------AKVKEMNERL--------EDE 931

Query: 547 DKANEEIAQVRTKAKAESAALHAGLRKEQM---KVESLERALQQKNQEIEELTKICDELI 603
           ++ N E+   + K + E + L   +   ++   KVE  + A + K + + E     DE+I
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991

Query: 604 AKLGK 608
           AKL K
Sbjct: 992 AKLTK 996


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 45/212 (21%), Positives = 106/212 (50%), Gaps = 16/212 (7%)

Query: 395  ESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYE----ETRQEVLEMRKIVAEY 450
            +  +D +  S S+KTA +      I T+++E +  K + E       QE+L   K V+E 
Sbjct: 1248 QETIDELRRSVSEKTAQI------INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301

Query: 451  EKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGF 510
            ++T+ ++    ++++     +  ++ ME+ +        +  +  L +  +NLK + E  
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361

Query: 511  KKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAG 570
            +   + LK+  ++ LA++ QE Q  Q   ++ +EK ++  + ++++      +SA L   
Sbjct: 1362 EVKHDQLKEHIRETLAKI-QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL--- 1417

Query: 571  LRKEQMKVESLERALQQKNQEIEELTKICDEL 602
              + ++++  L + LQ+ + E++ + K  D+L
Sbjct: 1418 --RIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/224 (21%), Positives = 105/224 (46%), Gaps = 36/224 (16%)

Query: 394 GESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKT 453
           G+ P D +C  E +    +T +++E+  KE+E NE        R+EV+ + ++     K+
Sbjct: 706 GKVPKDLLCNLELE--GKITDLQKEL-NKEVEENE------ALREEVILLSEL-----KS 751

Query: 454 IAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN 513
           +   +E  ++      +    +T EK++            S++  +   ++G+LE   K 
Sbjct: 752 LPSEVERLRKEIQDKSEELHIITSEKDKLF----------SEVVHKESRVQGLLEEIGKT 801

Query: 514 EEALKKCAQDYLARVKQEEQRYQALKIHAEEKL-------DKANEEIAQVRTKAKAESAA 566
           ++ L     +Y +   QE Q ++ L +  E+K        ++ N+EI  +  +A+   ++
Sbjct: 802 KDDLATTQSNYKS-TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860

Query: 567 LHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD 610
           L  G  K ++  ++ E  LQ+K +E++E     ++L  +L   D
Sbjct: 861 L--GALKTELSYKTQE--LQEKTREVQERLNEMEQLKEQLENRD 900



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 38/184 (20%), Positives = 85/184 (46%), Gaps = 12/184 (6%)

Query: 423  EIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQA 482
            EIE     K+ +E+  E+  + K   + ++ + ++++ E      + K      +E E+ 
Sbjct: 1420 EIEMLGLSKRLQESHDEMKSVAKEKDDLQR-LQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 483  L----ADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQAL 538
            L      L   E ++++L       +  +   +K  EA+    Q+ +  + ++E+++   
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK 1538

Query: 539  KIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKI 598
            +I   E  +K NE + Q +   KA+ +AL +     + K+  L   LQ+  +EI+ + K 
Sbjct: 1539 QI--SEVQEKVNE-LKQFKEHRKAKDSALQS----IESKMLELTNRLQESQEEIQIMIKE 1591

Query: 599  CDEL 602
             +E+
Sbjct: 1592 KEEM 1595



 Score = 36.6 bits (83), Expect = 0.069
 Identities = 61/232 (26%), Positives = 111/232 (47%), Gaps = 44/232 (18%)

Query: 378  LLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETR 437
            L ES  E   V+        L  +  SESD+      ++E I  KEI A     K+ ET 
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQ------LKENI--KEIVA-----KHLETE 1476

Query: 438  QEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE-QALADLNSVERSLSDL 496
            +E+      + E E+TI     +E R ++ S+K  +  T++K+ +A+ D   ++  + ++
Sbjct: 1477 EELKVAHCCLKEQEETI-----NELRVNL-SEKETEISTIQKQLEAIND--KLQNKIQEI 1528

Query: 497  FRRYE--NLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIA 554
            + + E  N+K + E  +K  E LK+  +   A+     Q  ++  +    +L ++ EEI 
Sbjct: 1529 YEKEEQFNIKQISEVQEKVNE-LKQFKEHRKAK-DSALQSIESKMLELTNRLQESQEEI- 1585

Query: 555  QVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
            Q+  K             KE+MK   ++ ALQ +  +++E TK   E++AK+
Sbjct: 1586 QIMIK------------EKEEMK--RVQEALQIERDQLKENTK---EIVAKM 1620



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 46/204 (22%), Positives = 93/204 (45%), Gaps = 16/204 (7%)

Query: 406 SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKI--VAEYEKTIAQMIEDE-- 461
           ++K  +   ++E+    E EA E K K ++  Q + E+  +  + ++ +   Q +E+E  
Sbjct: 519 TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578

Query: 462 QRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCA 521
            +  +  +K  Q   ++K Q   D   +E    DL    E++    E  K+ ++ L   A
Sbjct: 579 SKVELLREKEDQ---IKKLQEYIDSQKLENIKMDLSYSLESI----EDPKQMKQTLFD-A 630

Query: 522 QDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESL 581
           +      K+E    ++  +  +EK+ +      Q+    +   + L A   K++M+V+ L
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEA---KKKMQVD-L 686

Query: 582 ERALQQKNQEIEELTKICDELIAK 605
           E+ LQ    EI +LT + D  + K
Sbjct: 687 EKELQSAFNEITKLTSLIDGKVPK 710



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 42/216 (19%), Positives = 89/216 (41%), Gaps = 26/216 (12%)

Query: 404  SESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQM---IED 460
            SES+  ++ T   +++++   E  ++ +++  TR ++ +++  + +    I Q+     +
Sbjct: 2247 SESEFPSIKTEF-QQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN 2305

Query: 461  EQRTSMTSQKSFQQ--LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGF-------- 510
                 M     F++   T+ KE    DL S++     LF+ Y+ LK  L           
Sbjct: 2306 RIIAIMNESTEFEERSATISKEWE-QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ 2364

Query: 511  -KKNEEALKKCAQDYLARVKQEEQRYQALK---IHAEEKLDKANEE-------IAQVRTK 559
              KN     +  Q    ++++ E      K   +H E K+ K  +E       IA+++ K
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424

Query: 560  AKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL 595
                +  L       Q+  + +    +   +EIE+L
Sbjct: 2425 VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 54/259 (20%), Positives = 119/259 (45%), Gaps = 22/259 (8%)

Query: 356 SEAGIEKETCQKME--EDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLT 413
           SE   E ++ ++ E  E G+ +  LL++  +   + ++   E   D +   E + TA+  
Sbjct: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA--KEEQEDLLRKRERELTALKG 765

Query: 414 LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473
            ++EE+ + + E ++ K++Y+   Q + E  +   +  + +A      ++    ++   +
Sbjct: 766 ALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVK 825

Query: 474 QLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQ 533
            L  E E+       +ER ++ L R+ E+LKG       +E   K+  + Y   ++Q E+
Sbjct: 826 LLQEENEKLQGRSEELERRVAQLQRQIEDLKG-------DEAKAKETLKKYEGEIRQLEE 878

Query: 534 RYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIE 593
                 +HA     K  +E    R   + E  A    L +   + + L   L++++++ E
Sbjct: 879 AL----VHAR----KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930

Query: 594 ELTKICDELIAK---LGKT 609
           +L ++ +E+  +   LGKT
Sbjct: 931 QLRRLKNEMENERWHLGKT 949



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 53/255 (20%), Positives = 110/255 (43%), Gaps = 28/255 (10%)

Query: 366  QKMEEDGSTVLGLLESSAEKAP--VSVSCGGESPLDGICLSESDKTAVLTLIREEI---- 419
            +K E++  +    LE+  E A   +S +   +  L      ES++   L  ++ E+    
Sbjct: 884  RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943

Query: 420  --ITKEIEA--NEWKKKYEETRQEVLEMRKIVAEYE----KTIAQMIEDEQRTSMTSQKS 471
              + K IE    E     E +R   LE++  + EY+    + +A+M    +  ++ ++KS
Sbjct: 944  WHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003

Query: 472  -FQQLTMEKEQALAD--LNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARV 528
                + M+ E  L +  L   +R+  +   + + L+  L+  +   EA      D    V
Sbjct: 1004 RLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLV 1063

Query: 529  KQEEQRYQALKIHAE----------EKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKV 578
            KQ E +   L++  E          E++ ++ E++ Q+R +   E AA    L  +++ +
Sbjct: 1064 KQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAA-RQDLECDKISL 1122

Query: 579  ESLERALQQKNQEIE 593
            E   + L+ +   +E
Sbjct: 1123 ERQNKDLKSRIIHLE 1137



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 37/151 (24%), Positives = 69/151 (45%), Gaps = 12/151 (7%)

Query: 468 SQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLAR 527
           S    + L  +K +   ++  ++R L    +  +N+K   E  + N E L+    + +  
Sbjct: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE 664

Query: 528 VKQEEQRYQALKIHAEEKLDKANEEIAQV---RTKAKAESAALHAGLRKEQMKVESLERA 584
               +QR +     +E +L K  EE+ QV   R + + E   L   L +   +++S +R+
Sbjct: 665 NSTLQQRLE----ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720

Query: 585 L-QQKNQEIEELTK----ICDELIAKLGKTD 610
             ++K   IEEL +    + D LIAK  + D
Sbjct: 721 EDREKGALIEELLQAKQDLQDLLIAKEEQED 751


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/196 (25%), Positives = 90/196 (45%), Gaps = 21/196 (10%)

Query: 414 LIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ 473
           L  E+++ KE +  + + K     +++ E      E +  +     D+ +     Q++ Q
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-----DKTKQQHQEQQALQ 497

Query: 474 QLTMEK-EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEE 532
           Q T  K  +A  DL  V R + D  ++ +NL+ +L+  K+N   L+K  +D  A+++  E
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557

Query: 533 QRYQALKIHAEEKLDKANEEIAQVRTKAKAESAA-------LH-------AGLRKEQMKV 578
                L    +EK     E++ Q+  K K +S +       LH       A LR  Q +V
Sbjct: 558 GETAVLN-QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616

Query: 579 ESLERALQQKNQEIEE 594
            SLE ++ + N ++ E
Sbjct: 617 LSLETSVNELNSQLNE 632



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 47/212 (22%), Positives = 94/212 (44%), Gaps = 15/212 (7%)

Query: 395 ESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTI 454
           E+ L  I +  S+K      ++EE+   E +    K ++++ +Q+  E  +   + +  I
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 416

Query: 455 AQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNE 514
            Q+      T     ++  +L  +++ +   L   E+ ++DL  +   L+  L+    N 
Sbjct: 417 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNS 476

Query: 515 EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKE 574
             L    Q  L + KQ+ Q  QAL+     KL +A  ++ QV  +           +  +
Sbjct: 477 TEL----QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ-----------IGDK 521

Query: 575 QMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K+++LE  LQ+  + I  L K  ++L AK+
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKEREDLYAKI 553



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 53/242 (21%), Positives = 108/242 (44%), Gaps = 41/242 (16%)

Query: 406 SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLE-----------MRKIVAEYEKTI 454
           +D    L+ + E++  K   + E + + ++T+Q+  E           +R+   + E+ +
Sbjct: 456 ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515

Query: 455 AQMIEDEQRTS------MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYEN------ 502
            Q+ + +Q+          S+++   L  E+E   A + + E   + L +  E       
Sbjct: 516 RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE 575

Query: 503 --------LKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEE---KLDKANE 551
                   LK   E  K+ +E L    Q+  A ++  + R  +L+    E   +L+++ E
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635

Query: 552 EIAQ--VRTKAKAE-----SAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIA 604
           +++Q  ++ KAK E      AA  A     Q  +++ + ALQ K QE+ ++T   D++ A
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695

Query: 605 KL 606
           KL
Sbjct: 696 KL 697



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 42/195 (21%), Positives = 86/195 (44%), Gaps = 1/195 (0%)

Query: 408  KTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMT 467
            KTA  TL  ++   KE +  E  K  ++ ++E     K +   +  +A++ E + R    
Sbjct: 1081 KTAKATL-EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139

Query: 468  SQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLAR 527
              K  ++L   K +++ ++ +++ +   L ++   L+G  +  K   E  K+  Q    +
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199

Query: 528  VKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQ 587
            VK+EE+  +   I  E KL    +E      K +   A L   +      + ++++  Q 
Sbjct: 1200 VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259

Query: 588  KNQEIEELTKICDEL 602
              + + EL K  D+L
Sbjct: 1260 SQRRVSELEKQTDDL 1274



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 35/171 (20%), Positives = 72/171 (42%), Gaps = 1/171 (0%)

Query: 425 EANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALA 484
           + NE K+K  +   ++    +++   E        D Q    T+Q + Q    E  +   
Sbjct: 629 QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688

Query: 485 DLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEE 544
            L+ V   L D       L+  L+ +K+   +L++  ++   ++K+ E     +K   E+
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748

Query: 545 KLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL 595
            L    ++  Q+ T  +  +  L   L  E+  V S    LQ+K++ +E +
Sbjct: 749 ALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 46/193 (23%), Positives = 88/193 (45%), Gaps = 24/193 (12%)

Query: 427  NEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADL 486
            NE K+  E+ ++++  ++    E +  + Q  E E +      ++ Q+L  EKE+     
Sbjct: 962  NELKQSSEQKKKQIEALQ---GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018

Query: 487  NSVERS-------LSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA---RVKQEEQRYQ 536
            N+ E+S        SD + R   L    +  K  EE L    +D ++   ++  + +  Q
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078

Query: 537  ALK-IHAEEKLDKANEEIAQVRTKAKA------ESAALHAGLRKEQMKVESLERALQQKN 589
             LK   A  + D A +E  Q++ + KA      E +     L  E+ K+  +E   + K 
Sbjct: 1079 ELKTAKATLEQDSAKKE-QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE---EIKC 1134

Query: 590  QEIEELTKICDEL 602
            ++ +E+TK+ +EL
Sbjct: 1135 RQEKEITKLNEEL 1147



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/280 (21%), Positives = 116/280 (41%), Gaps = 43/280 (15%)

Query: 340 ECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLD 399
           + S  P++T++    SS  G     C K       +    E+  +    S   GGES L 
Sbjct: 21  DSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDS-GHGGESNL- 78

Query: 400 GICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIE 459
              L   D    +TL+R+E+   +    E K   EE ++E LE  + + + E     ++ 
Sbjct: 79  --ALKRDD----VTLLRQEVQDLQASLKEEKWYSEELKKE-LEKYQGLQQQEAKPDGLVT 131

Query: 460 DEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKK 519
           D                       A+L S+E+ L +      N+K + + F++    L  
Sbjct: 132 DSS---------------------AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT 170

Query: 520 CAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAAL--------HAGL 571
                +A +K +    ++L+  AE+K+ +  EE+ +  T  +     L         A L
Sbjct: 171 ----EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226

Query: 572 RKEQMKVESL-ERALQQKNQEIEELTKICDELIAKLGKTD 610
           +KE ++V++L +    ++ +E E+L   C +L ++   ++
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 59/345 (17%), Positives = 133/345 (38%), Gaps = 50/345 (14%)

Query: 291 EGAVISQISDISNRDGHATDE--EKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVST 348
           E AV++Q+ + ++       +  EKL + S   K A   +  + +E   +   +   V +
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618

Query: 349 INHAFS--SSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSES 406
           +  + +  +S+    KE   +++        LL  SAE A  +     ++ LD    +  
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELL-LSAEAAKTAQRADLQNHLDTAQNALQ 677

Query: 407 DK-------TAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIE 459
           DK       T  L  +  ++  K+   ++ +   +E +++ L + +   E E  I ++  
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737

Query: 460 DEQRTSMTSQKSFQQLTMEKE--------------QALADLNSVERSLSDLFRRYENLKG 505
           D      + +++ Q L  +++              Q   +   V  +  DL ++ E L+ 
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797

Query: 506 VLEGFKKNEEALKKCAQDY------------------------LARVKQEEQRYQALKIH 541
           + +   K EE  +   QD+                        L +VK E++        
Sbjct: 798 IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857

Query: 542 AEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQ 586
            ++KL K ++ +   +++ + E+    A +   +   + L+  LQ
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902


>gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo
           sapiens]
          Length = 669

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 60/273 (21%), Positives = 109/273 (39%), Gaps = 29/273 (10%)

Query: 354 SSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGI----------CL 403
           S S++G    +       G    GLL S    +P S SCG  SP              C+
Sbjct: 269 SHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCV 328

Query: 404 SES---DKTAVLTLIREEIITKEI--------EANEWKKKYEETRQEVLEMRKIVAEYEK 452
            E    D+ A L  +R+ +   E             W+++ E  R++     +     ++
Sbjct: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388

Query: 453 TIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKK 512
            +   +   Q+     Q  F QL  E+EQ      ++ER   +L  R E  K  +     
Sbjct: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448

Query: 513 NEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLR 572
               LK+  ++  A + Q+     AL++   E   +A   +++ R +   E+A      R
Sbjct: 449 EISLLKQQLKESQAELVQKGSELVALRVALREA--RATLRVSEGRARGLQEAA------R 500

Query: 573 KEQMKVESLERALQQKNQEIEELTKICDELIAK 605
             ++++E+  + LQ+  QE E+L +   +L A+
Sbjct: 501 ARELELEACSQELQRHRQEAEQLREKAGQLDAE 533


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 757 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 812

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 813 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 872

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 873 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 932

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 933 NQLAECKKQHQEVIS 947



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 98/468 (20%), Positives = 189/468 (40%), Gaps = 73/468 (15%)

Query: 163 ISKSAGLEQPTDPVARDGPL---SQTSSKPDPSQWESPSFNPFGSHSVLQ----NSPPLS 215
           IS+ A L+ PT P   D      S+ S  P   +   P  +P     V       S PLS
Sbjct: 244 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 303

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVK 275
            + S  F    F   +   +      + D  S +    + +L+   +A  + + S  + K
Sbjct: 304 GKESVFFAEPPFKAEISSIRE-----NKDRLSDSTTGADSLLDISSEADQQDLLSLLQAK 358

Query: 276 -------KHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEV 328
                    E Q   L A S  E       +D+S    H+T  +   S     +++  + 
Sbjct: 359 VASLTLHNKELQD-KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDS 412

Query: 329 KGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAP 387
           K  P          +V + ++  + + ++  I     Q+++E    +   LESS AE+  
Sbjct: 413 KSSP----------SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQ 457

Query: 388 VSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIV 447
           + V        + +CL+ ++       I E       +  E + KYEE  +EVL ++K  
Sbjct: 458 LQVELQSRRA-ELVCLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK-- 507

Query: 448 AEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVL 507
               +    ++  E   SM +   F +L + +E+       ++ +L +  R  E ++ + 
Sbjct: 508 ----QMKLGLVSPE---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 560

Query: 508 EGFKKNEE--ALKKCAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRT 558
           E   + E+   +K   ++Y    ++ +  Y ++       K    EK  +A EEI +++ 
Sbjct: 561 EKLVEREKGTVIKPPVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 616

Query: 559 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K++     A    E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 617 TLKSQMTQ-EASDEAEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 662



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 837 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 888

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 889 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 939

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 940 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 980


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 746 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 801

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 802 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 861

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 862 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 921

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 922 NQLAECKKQHQEVIS 936



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 98/468 (20%), Positives = 189/468 (40%), Gaps = 73/468 (15%)

Query: 163 ISKSAGLEQPTDPVARDGPL---SQTSSKPDPSQWESPSFNPFGSHSVLQ----NSPPLS 215
           IS+ A L+ PT P   D      S+ S  P   +   P  +P     V       S PLS
Sbjct: 233 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 292

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVK 275
            + S  F    F   +   +      + D  S +    + +L+   +A  + + S  + K
Sbjct: 293 GKESVFFAEPPFKAEISSIRE-----NKDRLSDSTTGADSLLDISSEADQQDLLSLLQAK 347

Query: 276 -------KHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEV 328
                    E Q   L A S  E       +D+S    H+T  +   S     +++  + 
Sbjct: 348 VASLTLHNKELQD-KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDS 401

Query: 329 KGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAP 387
           K  P          +V + ++  + + ++  I     Q+++E    +   LESS AE+  
Sbjct: 402 KSSP----------SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQ 446

Query: 388 VSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIV 447
           + V        + +CL+ ++       I E       +  E + KYEE  +EVL ++K  
Sbjct: 447 LQVELQSRRA-ELVCLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK-- 496

Query: 448 AEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVL 507
               +    ++  E   SM +   F +L + +E+       ++ +L +  R  E ++ + 
Sbjct: 497 ----QMKLGLVSPE---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 549

Query: 508 EGFKKNEE--ALKKCAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRT 558
           E   + E+   +K   ++Y    ++ +  Y ++       K    EK  +A EEI +++ 
Sbjct: 550 EKLVEREKGTVIKPPVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 605

Query: 559 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K++     A    E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 606 TLKSQMTQ-EASDEAEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 651



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 826 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 877

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 878 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 928

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 929 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 969


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 725 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 780

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 781 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 840

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 841 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 900

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 901 NQLAECKKQHQEVIS 915



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 99/454 (21%), Positives = 186/454 (40%), Gaps = 74/454 (16%)

Query: 163 ISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHF 222
           IS+ A L+ PT P        Q S    P    S   +  G  SV    PP  +E S   
Sbjct: 241 ISQDADLKTPTKP-------KQLSDVSSPRSITSTPLS--GKESVFFAEPPFKAEIS--- 288

Query: 223 DPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSL 282
              +  E+ D    +TT   S     +     ++L S  +AK   +T    +   E Q  
Sbjct: 289 ---SIRENKDRLSDSTTGADSLLDISSEADQQDLL-SLLQAKVASLT----LHNKELQD- 339

Query: 283 ALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECS 342
            L A S  E       +D+S    H+T  +   S     +++  + K  P          
Sbjct: 340 KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP---------- 384

Query: 343 NVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAPVSVSCGGESPLDGI 401
           +V + ++  + + ++  I     Q+++E    +   LESS AE+  + V        + +
Sbjct: 385 SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQLQVELQSRRA-ELV 438

Query: 402 CLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDE 461
           CL+ ++       I E       +  E + KYEE  +EVL ++K      +    ++  E
Sbjct: 439 CLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK------QMKLGLVSPE 485

Query: 462 QRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEE--ALKK 519
              SM +   F +L + +E+       ++ +L +  R  E ++ + E   + E+   +K 
Sbjct: 486 ---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKP 542

Query: 520 CAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRTKAKAESAALHAGLR 572
             ++Y    ++ +  Y ++       K    EK  +A EEI +++   K++     A   
Sbjct: 543 PVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQ-EASDE 597

Query: 573 KEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
            E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 598 AEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 630



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 805 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 856

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 857 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 907

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 908 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 948


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 754 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 809

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 810 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 869

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 870 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 929

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 930 NQLAECKKQHQEVIS 944



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 98/468 (20%), Positives = 189/468 (40%), Gaps = 73/468 (15%)

Query: 163 ISKSAGLEQPTDPVARDGPL---SQTSSKPDPSQWESPSFNPFGSHSVLQ----NSPPLS 215
           IS+ A L+ PT P   D      S+ S  P   +   P  +P     V       S PLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVK 275
            + S  F    F   +   +      + D  S +    + +L+   +A  + + S  + K
Sbjct: 301 GKESVFFAEPPFKAEISSIRE-----NKDRLSDSTTGADSLLDISSEADQQDLLSLLQAK 355

Query: 276 -------KHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEV 328
                    E Q   L A S  E       +D+S    H+T  +   S     +++  + 
Sbjct: 356 VASLTLHNKELQD-KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDS 409

Query: 329 KGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAP 387
           K  P          +V + ++  + + ++  I     Q+++E    +   LESS AE+  
Sbjct: 410 KSSP----------SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQ 454

Query: 388 VSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIV 447
           + V        + +CL+ ++       I E       +  E + KYEE  +EVL ++K  
Sbjct: 455 LQVELQSRRA-ELVCLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK-- 504

Query: 448 AEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVL 507
               +    ++  E   SM +   F +L + +E+       ++ +L +  R  E ++ + 
Sbjct: 505 ----QMKLGLVSPE---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 557

Query: 508 EGFKKNEE--ALKKCAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRT 558
           E   + E+   +K   ++Y    ++ +  Y ++       K    EK  +A EEI +++ 
Sbjct: 558 EKLVEREKGTVIKPPVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 613

Query: 559 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K++     A    E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 614 TLKSQMTQ-EASDEAEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 659



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 834 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 885

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 886 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 936

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 937 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 977


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 754 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 809

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 810 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 869

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 870 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 929

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 930 NQLAECKKQHQEVIS 944



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 98/468 (20%), Positives = 189/468 (40%), Gaps = 73/468 (15%)

Query: 163 ISKSAGLEQPTDPVARDGPL---SQTSSKPDPSQWESPSFNPFGSHSVLQ----NSPPLS 215
           IS+ A L+ PT P   D      S+ S  P   +   P  +P     V       S PLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVK 275
            + S  F    F   +   +      + D  S +    + +L+   +A  + + S  + K
Sbjct: 301 GKESVFFAEPPFKAEISSIRE-----NKDRLSDSTTGADSLLDISSEADQQDLLSLLQAK 355

Query: 276 -------KHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEV 328
                    E Q   L A S  E       +D+S    H+T  +   S     +++  + 
Sbjct: 356 VASLTLHNKELQD-KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDS 409

Query: 329 KGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAP 387
           K  P          +V + ++  + + ++  I     Q+++E    +   LESS AE+  
Sbjct: 410 KSSP----------SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQ 454

Query: 388 VSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIV 447
           + V        + +CL+ ++       I E       +  E + KYEE  +EVL ++K  
Sbjct: 455 LQVELQSRRA-ELVCLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK-- 504

Query: 448 AEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVL 507
               +    ++  E   SM +   F +L + +E+       ++ +L +  R  E ++ + 
Sbjct: 505 ----QMKLGLVSPE---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 557

Query: 508 EGFKKNEE--ALKKCAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRT 558
           E   + E+   +K   ++Y    ++ +  Y ++       K    EK  +A EEI +++ 
Sbjct: 558 EKLVEREKGTVIKPPVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 613

Query: 559 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K++     A    E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 614 TLKSQMTQ-EASDEAEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 659



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 834 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 885

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 886 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 936

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 937 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 977


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 39/195 (20%), Positives = 104/195 (53%), Gaps = 9/195 (4%)

Query: 415 IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
           ++E + +KE+E  + +K+  E +  + +     + YEK  + +   E   S+ + K  ++
Sbjct: 754 LKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSL---ESEVSVLASK-LKE 809

Query: 475 LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN-EEALKKC--AQDYLARVKQE 531
              EKE+  +++  +   +S + R  EN++ +L+  ++   E L+K   AQ+ LA +K+ 
Sbjct: 810 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 869

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALH--AGLRKEQMKVESLERALQQKN 589
            +    L+   ++K+++ ++E+ +++    + S   +  +  +++  ++E+L++ ++Q  
Sbjct: 870 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 929

Query: 590 QEIEELTKICDELIA 604
            ++ E  K   E+I+
Sbjct: 930 NQLAECKKQHQEVIS 944



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 98/468 (20%), Positives = 189/468 (40%), Gaps = 73/468 (15%)

Query: 163 ISKSAGLEQPTDPVARDGPL---SQTSSKPDPSQWESPSFNPFGSHSVLQ----NSPPLS 215
           IS+ A L+ PT P   D      S+ S  P   +   P  +P     V       S PLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300

Query: 216 SEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVK 275
            + S  F    F   +   +      + D  S +    + +L+   +A  + + S  + K
Sbjct: 301 GKESVFFAEPPFKAEISSIRE-----NKDRLSDSTTGADSLLDISSEADQQDLLSLLQAK 355

Query: 276 -------KHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEV 328
                    E Q   L A S  E       +D+S    H+T  +   S     +++  + 
Sbjct: 356 VASLTLHNKELQD-KLQAKSPKEAE-----ADLSFDSYHSTQTDLGPSLGKPGETSPPDS 409

Query: 329 KGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESS-AEKAP 387
           K  P          +V + ++  + + ++  I     Q+++E    +   LESS AE+  
Sbjct: 410 KSSP----------SVLIHSLGKSTTDNDVRI-----QQLQEILQDLQKRLESSEAERKQ 454

Query: 388 VSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIV 447
           + V        + +CL+ ++       I E       +  E + KYEE  +EVL ++K  
Sbjct: 455 LQVELQSRRA-ELVCLNNTE-------ISENSSDLSQKLKETQSKYEEAMKEVLSVQK-- 504

Query: 448 AEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVL 507
               +    ++  E   SM +   F +L + +E+       ++ +L +  R  E ++ + 
Sbjct: 505 ----QMKLGLVSPE---SMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 557

Query: 508 EGFKKNEE--ALKKCAQDYLARVKQEEQRYQAL-------KIHAEEKLDKANEEIAQVRT 558
           E   + E+   +K   ++Y    ++ +  Y ++       K    EK  +A EEI +++ 
Sbjct: 558 EKLVEREKGTVIKPPVEEY----EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD 613

Query: 559 KAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             K++     A    E MK E++ R + + N+++ EL+++  E  A+L
Sbjct: 614 TLKSQMTQ-EASDEAEDMK-EAMNRMIDELNKQVSELSQLYKEAQAEL 659



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 35/163 (21%), Positives = 81/163 (49%), Gaps = 24/163 (14%)

Query: 407 DKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSM 466
           +K  + TL++    +KE E NE  +K+++ ++E+ EM++    Y ++ +++ ED+ +   
Sbjct: 834 EKENIQTLLK----SKEQEVNELLQKFQQAQEELAEMKR----YAESSSKLEEDKDKKIN 885

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLA 526
              K   +L    ++AL  L+ +  S S   R+ + L+ + +  K+ +  L +C      
Sbjct: 886 EMSKEVTKL----KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECK----- 936

Query: 527 RVKQEEQRYQALKIH----AEEKLDK-ANEEIAQVRTKAKAES 564
             KQ ++     ++H     + ++D+   + + Q+ T  K +S
Sbjct: 937 --KQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQS 977


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 78/382 (20%), Positives = 172/382 (45%), Gaps = 39/382 (10%)

Query: 229 ESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKV--KKHETQSLALDA 286
           E++   K   TL +S+        ++E L+  +K K   +    K+  +  + ++L ++ 
Sbjct: 300 ETIQSHKEQCTLLTSEK-EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL-IEQ 357

Query: 287 CSRDEGAVISQISDISNRDGHATDEE--KLASTSCGQKSAGAEVKGEPEEDLEYFECSNV 344
             +D+G VI++     +      +EE  +L S      + G E++ + E+          
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS------ERA 411

Query: 345 PVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSV----SCGGESPLDG 400
               +  A S+++    +E  +K++ +    +  +E ++E+  +S+    S   +  +D 
Sbjct: 412 AFEELEKALSTAQK--TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469

Query: 401 ICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIED 460
           +  S  ++ A L  + E+ + ++ +  E  KK +   +E  E  K+  E  K+ ++ ++ 
Sbjct: 470 MKKSSEEQIAKLQKLHEKELARKEQ--ELTKKLQTREREFQEQMKVALE--KSQSEYLKI 525

Query: 461 EQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKG-VLEGFKKNEEALKK 519
            Q        + ++L ++K+   A L   E  L DL +  E  +  +LE     E +L+K
Sbjct: 526 SQEKEQQESLALEELELQKK---AILTESENKLRDLQQEAETYRTRILE----LESSLEK 578

Query: 520 CAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE 579
             Q+        + + + L +H E + +K N+EI  +  K K E  +L    +++ +  E
Sbjct: 579 SLQE-------NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH--QQDALWTE 629

Query: 580 SLERALQQKNQEIEELTKICDE 601
            L+   QQ   E+E+L + C++
Sbjct: 630 KLQVLKQQYQTEMEKLREKCEQ 651



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/353 (21%), Positives = 162/353 (45%), Gaps = 52/353 (14%)

Query: 284  LDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSN 343
            ++  S    A++S+IS   +R      +E L   +C      A+++   EE         
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKV--KEALLIKTCTVSELEAQLRQLTEEQ-------- 1285

Query: 344  VPVSTINHAFSSSEAGIEKETCQ--KMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGI 401
               +T+N +F  +   +E++  Q   M+ D  +++   E+  ++         E      
Sbjct: 1286 ---NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES--- 1339

Query: 402  CLSE-----SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQ 456
            C+++     S+    +TL++EE+  K++E +   K+  +   + L+    ++E E  I+ 
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ-LQNSISLSEKEAAISS 1398

Query: 457  MIE--DEQRTSMTSQK---SFQQLTMEKEQ--ALADLNSVERSLSDL-------FRRYEN 502
            + +  DE++  +  Q    SF+  T+ KE+  AL  ++      S+        F +++N
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458

Query: 503  ----LKGVLEGFKKNEEALKKCAQDYLAR--VKQEEQRYQALKIHAEEKLDKANEEIAQV 556
                L+  LE   K++EA +K  Q  L +  + Q+ +R+  LK   E+   K  ++ + +
Sbjct: 1459 TVKELQIQLE--LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516

Query: 557  RTKAKAESAA---LHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
             T+ K+++A    L   + ++ +++ESL   L+  NQ+ +   K   EL+ KL
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK---ELVQKL 1566



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 8/129 (6%)

Query: 476 TMEKEQALADLNSVERSLSDLFRRYENL---KGVLEGFKKNEEALKKCAQD----YLARV 528
           ++ KEQ +  L  +ERSLS    +Y  L     +L+  KK  + +   +QD     +A +
Sbjct: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL 192

Query: 529 KQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQK 588
           ++E Q  Q  K H +E+ D + EE  Q  +  + + + L   LR   M V+ L + L Q 
Sbjct: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVL-KPLPQL 251

Query: 589 NQEIEELTK 597
             + E  TK
Sbjct: 252 EPQAEVFTK 260



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 43/185 (23%), Positives = 88/185 (47%), Gaps = 23/185 (12%)

Query: 429  WKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNS 488
            ++ K E+  +E  + ++I+ E E  I QM E ++       K  + LT +       ++ 
Sbjct: 888  YESKLEDGNKEQEQTKQILVEKENMILQMREGQK-------KEIEILTQKLSAKEDSIHI 940

Query: 489  VERSLSDLFRRYEN-LKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLD 547
            +       F+  E  ++ V +  K+ +E LKK   D  A++K+E +   AL++  +EK  
Sbjct: 941  LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN-TALELSQKEKQF 999

Query: 548  KA-------------NEEIAQVRTKAKAESAALHAGLRKEQMKVESL-ERALQQKNQEIE 593
             A             ++ ++++ T  K +  +L    R+E   V S+ E+ L Q+ +E++
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059

Query: 594  ELTKI 598
            E+ +I
Sbjct: 1060 EIHEI 1064



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 67/325 (20%), Positives = 138/325 (42%), Gaps = 33/325 (10%)

Query: 301  ISNRDGHATDEEKLASTSCGQK----SAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSS 356
            IS    + T++EKL      +K    S+  E++ + +E L   E +        H   S 
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK----QHEDQSM 1793

Query: 357  EAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIR 416
               +++E  +K ++    V   +E    K  +      E+  D +  +  +K     ++ 
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853

Query: 417  EEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEK--TIAQMIEDEQRTSM----TSQK 470
            ++I  KE+++   ++K        +EM ++ ++YEK   + QM    + T +    T +K
Sbjct: 1854 QKI--KELDSCLVRQKEVHR----VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907

Query: 471  SFQQLTMEK--EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARV 528
            S   L   K      A  N +E  L+   R  + L   +   +K+   L+K  Q  L  +
Sbjct: 1908 SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967

Query: 529  KQE--EQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGL---------RKEQMK 577
            K+E  ++R + +K   E+   K N  + Q+  +   + A     L         + ++++
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 578  VESLERALQQKNQEIEELTKICDEL 602
             E LE   ++ NQ ++++ +  D+L
Sbjct: 2028 AELLESHQEETNQLLKKIAEKDDDL 2052



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 57/297 (19%), Positives = 111/297 (37%), Gaps = 47/297 (15%)

Query: 328  VKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKM-------EEDGSTVLGLLE 380
            +K E E   +  E  N+ V +      + E  +E E+  K+       E+  + +   L 
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656

Query: 381  SSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEW-------KKKY 433
            S  E+       G ES L  +     ++   + ++ E++ + E   +E        K   
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716

Query: 434  EETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSL 493
              T QE  + +  V   +KT  + I   QR     +K  Q++  EKE+ ++    +    
Sbjct: 1717 AYTEQEEADSQGCV---QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773

Query: 494  SDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEI 553
             +   + E+                       A  KQ E   Q++  H +E+L++ N++ 
Sbjct: 1774 QERLIKLEH-----------------------AEAKQHED--QSMIGHLQEELEEKNKKY 1808

Query: 554  AQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD 610
            + +     A+      G    Q K ++LE       + ++E    C  L  K+ + D
Sbjct: 1809 SLI----VAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQKIKELD 1860



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 43/190 (22%), Positives = 74/190 (38%), Gaps = 31/190 (16%)

Query: 424  IEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQAL 483
            +E N+ ++    T     E+  +++ +EK + Q  E+        Q+  +    EKEQ +
Sbjct: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE-------LQEIHEIQLQEKEQEV 1073

Query: 484  ADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAE 543
            A+L                 K +L G +K E          +  +K+E  +        +
Sbjct: 1074 AELKQ---------------KILLFGCEKEE------MNKEITWLKEEGVKQDTTLNELQ 1112

Query: 544  EKLDKAN---EEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICD 600
            E+L + +     +AQ  TK KA    L   L K   +   L+  L +     EE  +   
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172

Query: 601  ELIAKLGKTD 610
            EL +KL  TD
Sbjct: 1173 ELTSKLKTTD 1182


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 55/196 (28%), Positives = 91/196 (46%), Gaps = 24/196 (12%)

Query: 416 REEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKT----------IAQMIEDEQRTS 465
           R++++  E++   ++ K     QE  EM   +A  E            + Q IE+ + T+
Sbjct: 293 RQKLLKLEVD---FEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETN 349

Query: 466 MTSQKSFQQLTMEKEQALAD-LNSVERSLSDLFRRYENL-KGVLEGFKKNEEALKKCAQD 523
              QK+ ++L     Q L D +   E   S L    ENL K VLE   K+EE  K  +Q 
Sbjct: 350 KNLQKAEEEL-----QELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQC 404

Query: 524 YLARVKQEEQRYQALKIHAE-EKLDKANEEIAQVR---TKAKAESAALHAGLRKEQMKVE 579
              R K +E+ + + ++  E EKL K   E+ ++    +K+K+E   LH  L KE+   +
Sbjct: 405 RELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTK 464

Query: 580 SLERALQQKNQEIEEL 595
            L   L+     ++EL
Sbjct: 465 DLLNELEVVKSRVKEL 480



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 64/291 (21%), Positives = 130/291 (44%), Gaps = 55/291 (18%)

Query: 354 SSSEAGIEKETCQKMEED---GSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTA 410
           S SE   +K+   + E+D     TV   L++S E       C  ++    + LS+ D   
Sbjct: 31  SLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGE-------CERKTK-KSLELSKEDLIQ 82

Query: 411 VLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAE--------------------- 449
           +L+++  E+  +E   +  K   E+T+ EVLE     AE                     
Sbjct: 83  LLSIMEGELQAREDVIHMLKT--EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIG 140

Query: 450 ---YEKTIAQMIEDEQRTSMTSQKSFQQLTMEKE---QALADLNSVERSLSDLFRRYENL 503
              YEK I+++   E++   T ++  +QL + ++   + + +L + +   +D   + ++ 
Sbjct: 141 EDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDF 200

Query: 504 KGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEK-LDKANEEIAQVRTKA-- 560
             +LE   +  E LKK        + ++E+ YQA K     K L+K  +E+ ++++ A  
Sbjct: 201 TNLLE---QERERLKK--------LLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALM 249

Query: 561 KAESAALH-AGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD 610
             +   +H   L  +  KV+ L + L+++ ++++ +T    E   KL K +
Sbjct: 250 LVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE 300



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 53/238 (22%), Positives = 96/238 (40%), Gaps = 48/238 (20%)

Query: 417 EEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQ-QL 475
           EEI   E +  E +KK +E      E+R  V + +K ++++ + E+  S +  +  Q  L
Sbjct: 395 EEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHL 454

Query: 476 TMEKEQALAD----------------------LNSVERSLSDLFRRYENLKGVL------ 507
            +EKE+ L                        L   E SL D   + ++   +L      
Sbjct: 455 NLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKN 514

Query: 508 ------------EGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQ 555
                       +G  KN +  +    D   ++ +E ++   LK   EEK+     E  +
Sbjct: 515 MMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDE 574

Query: 556 VRTKAKAE---SAALHAG---LRKEQMKVESLERALQQ-KNQEIEELTKICDELIAKL 606
           +  K K+E   S+ L      L+K    +E +ER + + ++++  ELT   D  I +L
Sbjct: 575 LIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKEL 632


>gi|56550043 sarcolemma associated protein [Homo sapiens]
          Length = 811

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 58/210 (27%), Positives = 96/210 (45%), Gaps = 26/210 (12%)

Query: 413 TLIREEIITKEIEANEWKKKYEE----TRQEVL-------EMRKIVAEYEKTIAQMIEDE 461
           TL R   IT+E     W+   +E    +R EV+          +      K +  + ED+
Sbjct: 188 TLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDK 247

Query: 462 QRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCA 521
                T+++S +++  EK + +  L+ VERSLS+      +LK + E   + +E L++ A
Sbjct: 248 HNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNE---RTQEELRELA 304

Query: 522 QDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESL 581
             Y   V + +     LK+ AE K     EEI Q   K +AE   L   + + + K + L
Sbjct: 305 NKYNGAVNEIKDLSDKLKV-AEGK----QEEIQQ---KGQAEKKELQHKIDEMEEKEQEL 356

Query: 582 E---RALQQKNQ-EIEELTKICDELIAKLG 607
           +    ALQ  N    E LT + + L++K G
Sbjct: 357 QAKIEALQADNDFTNERLTALQEHLLSKSG 386



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 40/202 (19%), Positives = 85/202 (42%), Gaps = 20/202 (9%)

Query: 406 SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTS 465
           S++   +  ++EE+     E   W+K   E  +E+  ++       +   Q  ED+QR  
Sbjct: 579 SERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSF----QLRCQQCEDQQREE 634

Query: 466 MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKK-----NEEALKKC 520
            T      +L  E E+   + N++E     L R    L   L+  +K      +++L+  
Sbjct: 635 AT------RLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELT 688

Query: 521 AQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVES 580
           +   + ++ ++E   Q   +  +   D A  ++  + +KA+ ++  +     K Q  +  
Sbjct: 689 SDLSILQMSRKELENQVGSLKEQHLRDSA--DLKTLLSKAENQAKDVQKEYEKTQTVLSE 746

Query: 581 LERALQQKNQEIEELTKICDEL 602
           L+   +   QE + +T   DEL
Sbjct: 747 LKLKFEMTEQEKQSIT---DEL 765



 Score = 32.7 bits (73), Expect = 1.00
 Identities = 31/141 (21%), Positives = 55/141 (39%), Gaps = 7/141 (4%)

Query: 412 LTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKS 471
           L  +R+E    E E +  K++      E+    K +   +K   ++  D     M+ ++ 
Sbjct: 642 LEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKEL 701

Query: 472 FQQLTMEKEQALAD-------LNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDY 524
             Q+   KEQ L D       L+  E    D+ + YE  + VL   K   E  ++  Q  
Sbjct: 702 ENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSI 761

Query: 525 LARVKQEEQRYQALKIHAEEK 545
              +KQ +   + L+     K
Sbjct: 762 TDELKQCKNNLKLLREKGNNK 782



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 38/204 (18%), Positives = 86/204 (42%), Gaps = 26/204 (12%)

Query: 412 LTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKS 471
           LT ++E +++K      +  ++ E +++++    +    E+T    +  E +T       
Sbjct: 374 LTALQEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEET---KLSKENQTRAKESDF 430

Query: 472 FQQLTMEKEQALADLNSV---ERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARV 528
              L+  KE++  D       E+ L++   +   LK  L+G +   EA            
Sbjct: 431 SDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEA------------ 478

Query: 529 KQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQ- 587
           KQE Q  +   I A+E    + ++  +++   + E  A    + +   +++ L+  LQ+ 
Sbjct: 479 KQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRL 538

Query: 588 -------KNQEIEELTKICDELIA 604
                  + ++  E+T   DEL++
Sbjct: 539 HIDTENLREEKDSEITSTRDELLS 562


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 54/226 (23%), Positives = 107/226 (47%), Gaps = 30/226 (13%)

Query: 399  DGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQM- 457
            D  CL   D+ A L  ++ ++      A E   K +   QE+  +R    +YE+   +  
Sbjct: 1496 DRKCLE--DENARLQRVQYDLQKANSSATETINKLKVQEQELTRLR---IDYERVSQERT 1550

Query: 458  IEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN--EE 515
            ++D+  T    Q S ++L ++K++   +LN ++R+ S+   + + L+  LEG +++  E+
Sbjct: 1551 VKDQDITRF--QNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQ 1608

Query: 516  ALK------KCAQDYLARVKQEE---QRYQALKIHAEEKLDKANEEIAQVRTKAKA---- 562
            A+K      +  Q  + + + E+   Q+   L  H  EK  +  EE+ ++ ++ +A    
Sbjct: 1609 AIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREK-QRTQEELRRLSSEVEALRRQ 1667

Query: 563  ----ESAALHAGLRKE--QMKVESLERALQQKNQEIEELTKICDEL 602
                + +   A LR E  Q  +E   R+L +   EIE L  + + L
Sbjct: 1668 LLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 40/182 (21%), Positives = 85/182 (46%), Gaps = 16/182 (8%)

Query: 422  KEIEA--NEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEK 479
            KEIE    E++++ +   +   E+ K+   Y++ I  +    +     ++ +  QLTM+K
Sbjct: 1325 KEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK 1384

Query: 480  EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALK 539
            E+   D +     + +L R   +L    E  K+ +  L +  ++ L RV+++ Q+ +A  
Sbjct: 1385 EE---DTSGYRAQIDNLTRENRSLS---EEIKRLKNTLTQTTEN-LRRVEEDIQQQKATG 1437

Query: 540  IHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKIC 599
                ++  +   E+ QV      ES        + +  ++   + +Q KN+EIE L ++ 
Sbjct: 1438 SEVSQRKQQLEVELRQVTQMRTEESV-------RYKQSLDDAAKTIQDKNKEIERLKQLI 1490

Query: 600  DE 601
            D+
Sbjct: 1491 DK 1492



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 34/166 (20%), Positives = 73/166 (43%), Gaps = 20/166 (12%)

Query: 430  KKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSV 489
            K++YE       E+ K+   Y + ++ +    +     ++ + ++++M+KE    D  ++
Sbjct: 1185 KREYEN------ELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKED---DSKNL 1235

Query: 490  ERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKA 549
               L  L R   +LK   E  + N+  L+  A +   R ++   + +A      +K    
Sbjct: 1236 RNQLDRLSRENRDLKD--EIVRLNDSILQ--ATEQRRRAEENALQQKACGSEIMQKKQHL 1291

Query: 550  NEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL 595
              E+ QV  +   ++A       + +  +E   + +Q KN+EIE L
Sbjct: 1292 EIELKQVMQQRSEDNA-------RHKQSLEEAAKTIQDKNKEIERL 1330



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 42/191 (21%), Positives = 79/191 (41%), Gaps = 21/191 (10%)

Query: 415  IREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQ 474
            + EE+   +  A+E   K ++  +E+  MR+ + E    I  + +  ++ S+  ++S   
Sbjct: 1573 VEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632

Query: 475  LTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQR 534
            L  +++     L   +R+  +L R                EAL++        VKQ   R
Sbjct: 1633 LRQQRDVLDGHLREKQRTQEELRR-----------LSSEVEALRRQLLQEQESVKQAHLR 1681

Query: 535  YQALKIHAEEKLDKANE---EIAQVRTKAK---AESAALHAGLRKEQMKVESLER----A 584
             +  +   E+K    NE   EI ++++  +    E   L   LR  +++ + L R    A
Sbjct: 1682 NEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEA 1741

Query: 585  LQQKNQEIEEL 595
               KN  I EL
Sbjct: 1742 DSDKNATILEL 1752



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 37/170 (21%), Positives = 74/170 (43%), Gaps = 22/170 (12%)

Query: 442  EMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYE 501
            E+R +  EY+       E +   + T  +   QL +   + L     ++  ++DL R  E
Sbjct: 1723 ELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTL----ELQGLINDLQRERE 1778

Query: 502  NLKGVLEGFKKN--------EEALKKCAQ------DYLARVKQEEQRYQALKIHAEEKLD 547
            NL+  +E F+K         +E+  +C Q        L ++K  EQ    L+   E++L+
Sbjct: 1779 NLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ-RLEDELN 1837

Query: 548  KAN---EEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEE 594
            +A    E   +V+ + + E   +   L + + +    E A+++   E E+
Sbjct: 1838 RAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK 1887



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 42/194 (21%), Positives = 86/194 (44%), Gaps = 44/194 (22%)

Query: 415  IREEIITKEIEANEWKKKYEETR---------QEVLEMRKIVAEYEKTIAQMIEDE---- 461
            +R+EI   + +A E   + +E++         +E L ++  V E +K   Q +EDE    
Sbjct: 1780 LRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1839

Query: 462  QRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCA 521
            + T     +  Q+L  EK+Q   DLN  +                   + + EEA++K  
Sbjct: 1840 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQ-----------------YSRKEEAIRK-- 1880

Query: 522  QDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESL 581
                  ++ E ++ +  K     ++++   EI ++  + + +   L    R+ Q ++E+ 
Sbjct: 1881 ------IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK---LEDSTRETQSQLET- 1930

Query: 582  ERALQQKNQEIEEL 595
            ER+  Q+  EI++L
Sbjct: 1931 ERSRYQR--EIDKL 1942



 Score = 30.4 bits (67), Expect = 5.0
 Identities = 34/166 (20%), Positives = 75/166 (45%), Gaps = 8/166 (4%)

Query: 431  KKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADL-NSV 489
            +K  +  +E L  +K+  E EK I +   + +R  +  Q+   +   E E  LA + N  
Sbjct: 1143 QKARQCEKENLGWQKL--ESEKAIKEKEYEIERLRVLLQEEGTR-KREYENELAKVRNHY 1199

Query: 490  ERSLSDLFRRYEN----LKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEK 545
               +S+L  +YE      K  ++     +E   K  ++ L R+ +E +  +   +   + 
Sbjct: 1200 NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDS 1259

Query: 546  LDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQE 591
            + +A E+  +    A  + A     ++K+Q     L++ +QQ++++
Sbjct: 1260 ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED 1305


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 51/187 (27%), Positives = 87/187 (46%), Gaps = 15/187 (8%)

Query: 420 ITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEK 479
           + + ++  E K  Y E  + + E+  I + YE+   Q I+D        ++    + +E+
Sbjct: 684 LQERLKNQEKKIDYFERAKRLEEIPLIKSAYEE---QRIKDMDLWEQQEEERITTMQLER 740

Query: 480 EQALADLNSVERSLSDLFRRYENLKGVL-----EGFKKNEEALKKCAQDYLA---RVKQE 531
           E+AL   N + R L D       LK        E  K+ EE L +   + L    R ++E
Sbjct: 741 EKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKE 800

Query: 532 EQRYQALKIHAEEKLDKANEEIAQVRT-KAKAESAALHAGLRKEQMKV---ESLERALQQ 587
           E+R    +   EE+  +A E++ + R  + +AE A     LR+ Q +V   E +ER  +Q
Sbjct: 801 ERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQ 860

Query: 588 KNQEIEE 594
           +  EIEE
Sbjct: 861 RELEIEE 867



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 50/219 (22%), Positives = 96/219 (43%), Gaps = 41/219 (18%)

Query: 416 REEIITKEIEANEWKKKYEET-RQEVLEMRK--IVAEYE----KTIAQMIEDEQRTSMTS 468
           +EE+  +E E  + +K  EE  RQE  E  K  I+ E+E    KT+ + +E  ++T + +
Sbjct: 591 KEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGA 650

Query: 469 Q--------------------KSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGV-L 507
           +                    K  +QL  EK++    L + E+ + D F R + L+ + L
Sbjct: 651 KAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKI-DYFERAKRLEEIPL 709

Query: 508 EGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKAN--------EEIAQVRTK 559
                 E+ +K    D     +QEE+R   +++  E+ L+  N         ++  +R K
Sbjct: 710 IKSAYEEQRIK----DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLK 765

Query: 560 AKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKI 598
           A  +S       + E+   E     L+++ ++ +E  +I
Sbjct: 766 AARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRI 804


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 58/250 (23%), Positives = 113/250 (45%), Gaps = 22/250 (8%)

Query: 351  HAFSSSEAGIEKETCQKME-----EDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSE 405
            HA S +E G + +  Q+++     E     L + + S+    VS S   ++ L+ IC + 
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKS---KANLEKICRTL 1253

Query: 406  SDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTS 465
             D+ +      EEI     E    K + +    E  E+ + + E E  ++Q+   +Q  +
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQT---EAGELSRQLEEKESIVSQLSRSKQAFT 1310

Query: 466  MTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYL 525
              +++  +QL  E +   A  ++++ S  D     E  +   EG  + + AL K   +  
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE-- 1368

Query: 526  ARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERAL 585
              V Q   +Y+   I   E+L++A +++AQ    ++ +  A++A       K  SLE+  
Sbjct: 1369 --VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA-------KCASLEKTK 1419

Query: 586  QQKNQEIEEL 595
            Q+   E+E+L
Sbjct: 1420 QRLQGEVEDL 1429



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 87/416 (20%), Positives = 159/416 (38%), Gaps = 70/416 (16%)

Query: 255  EILESPKKAKSRLITSGCKVKKHETQSLALDACS-RDEGAVISQISDISNRDGHATDEEK 313
            E+ E+ KK   RL  S  +V+    +  +L+    R +G V   + D+   +  A   +K
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445

Query: 314  LA----------STSCGQKSAGAEVKGEPEEDL--EYFECSNVPVSTINH--AFSSSEAG 359
                         T C +  A  E   +    L  E F+  N     ++           
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505

Query: 360  IEKETC---QKMEEDGSTVLGLLES----SAEKAPVSVSCG-GESPLDG----ICLSESD 407
            +E+E     +++ E+G T+  L +S      EKA + ++    E+ L+     I   + +
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565

Query: 408  KTAVLTLIREEIITKEIEANEWKKKYEETRQ--------EVLEMRKIVAEYEKTIAQMIE 459
             T V + I  +I  K+ E  + K+ Y+ T +        EV    + +   +K    + E
Sbjct: 1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625

Query: 460  DEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKK 519
             E + S  ++++ + L          L   +  L D  R  E+LK  L   ++    L+ 
Sbjct: 1626 IEIQLSHANRQAAETLK-HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684

Query: 520  CAQDYLARVKQEE--------------QRYQALK------IHAEEKLDK----------- 548
              ++  A ++Q E              +R Q L       IH ++KL+            
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744

Query: 549  ANEEIAQVRTKAK---AESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDE 601
            A+ +      KAK    ++A +   L+KEQ     LER  +   Q +++L    DE
Sbjct: 1745 ASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1800



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 78/363 (21%), Positives = 148/363 (40%), Gaps = 63/363 (17%)

Query: 296  SQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHA--- 352
            ++I +++ R   A DEE++ +    +K    +   E ++D++  E +   V    HA   
Sbjct: 918  AKIKEVTER---AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974

Query: 353  --------FSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLS 404
                     S  +  I K T +K     +    L +  AE+  V+     +S L+     
Sbjct: 975  KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE----- 1029

Query: 405  ESDKTAVLTLIREEIITKEIEANEWKKKYE-----------ETRQEVLEMRKIVAEYEKT 453
            +  +    +L +E+ +  ++E N+ K + +           E  ++ L+ R    ++E  
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089

Query: 454  IAQM-IEDEQRTSMTSQKSFQQL---------TMEKEQALADLNSVERS-----LSDLFR 498
              Q  +EDEQ   +  QK  ++L          +E E+A       +RS     L +L  
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149

Query: 499  RYENLKGV----LEGFKKNEEALKKCAQDYLARVKQEEQRYQAL-KIHAEE--KLDKANE 551
            R E   GV    +E  KK E    K  +D      Q E    AL K HA+   +L +  +
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209

Query: 552  EIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKIC----DELIAKLG 607
             + +V+ K + E +         +++++ L  +++  ++    L KIC    D+L    G
Sbjct: 1210 NLQRVKQKLEKEKSEF-------KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262

Query: 608  KTD 610
            K +
Sbjct: 1263 KNE 1265



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 51/215 (23%), Positives = 96/215 (44%), Gaps = 29/215 (13%)

Query: 415  IREEIITKEIEANEWKKKYEETRQ--EVLEMRKIVAEYE----KTIAQMIEDEQRTSMTS 468
            ++E++   E  AN  + + EE R   E  E  + +AE E        Q++  +  + + +
Sbjct: 1668 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHT 1727

Query: 469  QKSFQ----QLTMEKEQALADLNSVE----RSLSDLFRRYENLK------GVLEGFKKNE 514
            +K  +    QL  E E A  D  + E    ++++D     E LK        LE  KKN 
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN- 1786

Query: 515  EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAE---SAALHAGL 571
              L++  +D   R+ + EQ   ALK   ++++ K    I ++  + + E   +     GL
Sbjct: 1787 --LEQTVKDLQHRLDEAEQL--ALK-GGKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841

Query: 572  RKEQMKVESLERALQQKNQEIEELTKICDELIAKL 606
            RK + +V+ L    ++  + +  L  + D+L  K+
Sbjct: 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1876


>gi|23503243 Ras association (RalGDS/AF-6) domain family
           (N-terminal) member 8 [Homo sapiens]
          Length = 392

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 36/198 (18%)

Query: 408 KTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMT 467
           +T  L  I +++ + EIE   W++KY    +E     +IV   +K     +E E+     
Sbjct: 173 QTEKLQSIEKQLESNEIEIRFWEQKYNSNLEE-----EIVRLEQKIKRNDVEIEEEEFWE 227

Query: 468 SQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLAR 527
           ++   +Q   E E+ L D                 L+ + +   + E  LK    DYLA+
Sbjct: 228 NELQIEQ---ENEKQLKD----------------QLQEIRQKITECENKLK----DYLAQ 264

Query: 528 VKQEEQRYQALKIHAEEKLDKANEEIAQVRT-KAKAE-------SAALHAGLRKEQMKVE 579
           ++  E   +A K+  E +  + NEE  + +  K K E       S  L  G++  +  + 
Sbjct: 265 IRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLG 324

Query: 580 SLERALQQKNQEIEELTK 597
              + LQ K QE+E+LTK
Sbjct: 325 QATKRLQDKEQELEQLTK 342


>gi|225579095 S-phase cyclin A-associated protein in the ER isoform
           b [Homo sapiens]
          Length = 1154

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 38/189 (20%), Positives = 93/189 (49%), Gaps = 12/189 (6%)

Query: 413 TLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEK------TIAQMIEDEQRTSM 466
           TL  ++++ +E +  +WK++  + R+ ++E + + AE+++       + +  E+E + + 
Sbjct: 320 TLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNE 379

Query: 467 TSQKSFQQLTMEKEQALADLNSVERSLSDL----FRRYENLKGVLEGFKKNEEALKKCAQ 522
            +  +  +   ++   L+ L   E+ L++L     RR E  +   E  ++ + AL+   Q
Sbjct: 380 IAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQ 439

Query: 523 DYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLE 582
             +  +  + +  +A      ++ +KA E+ A+ R + + E  A     ++E M  E L+
Sbjct: 440 ARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAM--EELQ 497

Query: 583 RALQQKNQE 591
           + +Q K+ E
Sbjct: 498 KKIQLKHDE 506



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 67/327 (20%), Positives = 136/327 (41%), Gaps = 50/327 (15%)

Query: 288 SRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVS 347
           S     V+++  ++++R   A +EE +AS    ++    E++ E   D+         + 
Sbjct: 169 SNSMAEVLAKKEELADRLEKA-NEEAIASAIAEEEQLTREIEAEENNDIN--------IE 219

Query: 348 TINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCG-------GESPLDG 400
           T N +  S+  G    +   M  D + VL   E+  E    + S G          P  G
Sbjct: 220 TDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEAR-ESWRQNTSWGDIVEEEPARPPGHG 278

Query: 401 ICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKT--IAQMI 458
           I + E   +           +++    E KKK+EE + +  ++R+ + E EKT  + +++
Sbjct: 279 IHMHEKLSSP----------SRKRTIAESKKKHEEKQMKAQQLREKLRE-EKTLKLQKLL 327

Query: 459 EDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALK 518
           E E+      ++   Q     E         E+ L   F+R   L+ +++  ++ E  + 
Sbjct: 328 EREKDVRKWKEELLDQRRRMME---------EKLLHAEFKREVQLQAIVKKAQEEEAKVN 378

Query: 519 KCA-----------QDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAAL 567
           + A            D L+++K+ EQR   L+   + + ++       V+ + +A  A  
Sbjct: 379 EIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAER 438

Query: 568 HAGLRKEQMKVESLERALQQKNQEIEE 594
            A + +  MK +  E  ++Q+ QE E+
Sbjct: 439 QARVEELLMKRKEQEARIEQQRQEKEK 465



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 23/151 (15%)

Query: 434 EETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSL 493
           +  R +VL   K   EYE+ + ++ E+ QR     Q   + +   K    A+  +    L
Sbjct: 389 QNKRHDVLSKLK---EYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEEL 445

Query: 494 SDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKAN--- 550
             L +R E    + +  ++ E+A +  A++   R +  E+R  AL    +E +++     
Sbjct: 446 --LMKRKEQEARIEQQRQEKEKAREDAARE---RARDREERLAALTAAQQEAMEELQKKI 500

Query: 551 ------------EEIAQVRTKAKAESAALHA 569
                       E+I Q + KA   S+  HA
Sbjct: 501 QLKHDESIRRHMEQIEQRKEKAAELSSGRHA 531


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 64/295 (21%), Positives = 121/295 (41%), Gaps = 13/295 (4%)

Query: 320  GQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKE--TCQKMEEDGSTVLG 377
            G+   G   + E  E L+  +     VS   +   S    + KE  + +    D   +L 
Sbjct: 1291 GRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1350

Query: 378  LLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETR 437
              E+ A+ A  S     E+   G+     ++ A       E+ T + + +EW+++ EE  
Sbjct: 1351 E-ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1409

Query: 438  QEVL---EMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLS 494
              +    E R+  A   + + Q + ++  T    ++  ++L  E + A  DL    + +S
Sbjct: 1410 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1469

Query: 495  DLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI-HAEEKLDKANEEI 553
             L ++      +L   ++    L+   +   A  +  E+  +AL +  A E+  +A EE+
Sbjct: 1470 TLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1527

Query: 554  AQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL----TKICDELIA 604
             +     +AE  AL +        V  LERA +   Q   +L    T++ DEL A
Sbjct: 1528 ERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1582



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 37/214 (17%)

Query: 428  EWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTME--------K 479
            E+  +  E  ++V  + K+  +YE TIA M ED  R     ++  ++L           +
Sbjct: 1035 EFSSQAAEEEEKVKSLNKLRLKYEATIADM-EDRLRKEEKGRQELEKLKRRLDGESSELQ 1093

Query: 480  EQALADLNSVERSLSDLFRRYENLKG--------------VLEGFKKNEEALKKCAQDY- 524
            EQ +      E   + L R+ E L+               +L+  ++ + AL +  +D  
Sbjct: 1094 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1153

Query: 525  ---LARVKQEEQR------YQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQ 575
               +AR K E+QR       +AL+   E+ LD  N +  ++R+K + E   L   L +E 
Sbjct: 1154 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEET 1212

Query: 576  MKVESLERALQQKN-QEIEELTKICDELIAKLGK 608
               E+  + L+Q++ Q + EL +  ++  A+ GK
Sbjct: 1213 RIHEAAVQELRQRHGQALGELAEQLEQ--ARRGK 1244



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 76/377 (20%), Positives = 144/377 (38%), Gaps = 42/377 (11%)

Query: 254  NEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHAT---- 309
            +E+ E   + + R      ++ + E +  A  A + DEG   +Q+   S R+  A     
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK-SLREAQAALAEA 1148

Query: 310  ----DEEKLASTSCGQ--KSAGAEV---KGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 360
                + E++A T   +  +  G E+   +GE E+ L+         S      +  +  +
Sbjct: 1149 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1208

Query: 361  EKET------CQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTL 414
            E+ET       Q++ +     LG L    E+A       G+   +   L+   + + L  
Sbjct: 1209 EEETRIHEAAVQELRQRHGQALGELAEQLEQAR-----RGKGAWEKTRLALEAEVSELRA 1263

Query: 415  IREEIITKEIEANEWKKKYEETRQEVL---------------EMRKIVAEYEKTIAQMIE 459
                + T   E  + +++ E   QEV                ++++  AE E     + E
Sbjct: 1264 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1323

Query: 460  DEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKK 519
             E +T   S K       +   A   L    R+   L  R   ++    G ++  E  + 
Sbjct: 1324 AESKTIRLS-KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE-EA 1381

Query: 520  CAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE 579
             A++   R  Q  Q   +     +E+   A E   + R +A  E+ AL   L ++   V+
Sbjct: 1382 AARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1441

Query: 580  SLERALQQKNQEIEELT 596
             LER  ++  QE+++ T
Sbjct: 1442 RLERGRRRLQQELDDAT 1458



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 33/168 (19%)

Query: 469  QKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDY---- 524
            ++  ++    +E+A  +L + +  LS+  RR E   G LE     EEA ++ A++     
Sbjct: 1374 REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA---GEEARRRAAREAEALT 1430

Query: 525  --LARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTK---------------AKAESAAL 567
              LA   +   R +  +   +++LD A  ++ Q R                 A+ ++A L
Sbjct: 1431 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1490

Query: 568  HAGLRKEQMKVE---------SLERALQQKNQEIEELTKICDELIAKL 606
             A   +E+ + E         SL RAL+++ +  EEL +    L A+L
Sbjct: 1491 RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1538



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 41/159 (25%), Positives = 83/159 (52%), Gaps = 14/159 (8%)

Query: 442  EMRKIVAEYEKT--IAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRR 499
            ++ K V E E+   +A+   ++ R  +T  +   +LT  ++  L     +E ++  L  +
Sbjct: 1547 DVGKSVHELERACRVAEQAANDLRAQVTELED--ELTAAEDAKLR----LEVTVQALKTQ 1600

Query: 500  YE-NLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQ-ALKIHAEEKLDKANEEI-AQV 556
            +E +L+G  E  ++    L K  +D  A V+++E+R Q  L + A +KL+   EE+ AQ+
Sbjct: 1601 HERDLQGRDEAGEERRRQLAKQLRD--AEVERDEERKQRTLAVAARKKLEGELEELKAQM 1658

Query: 557  RTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL 595
             +  + +  A+   LRK Q +++ L R +++     EE+
Sbjct: 1659 ASAGQGKEEAVKQ-LRKMQAQMKELWREVEETRTSREEI 1696



 Score = 29.6 bits (65), Expect = 8.5
 Identities = 36/202 (17%), Positives = 79/202 (39%), Gaps = 5/202 (2%)

Query: 398  LDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTI--- 454
            L+ +  S+ D    +  +       E  AN+ + +  E   E+          E T+   
Sbjct: 1538 LEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQAL 1597

Query: 455  -AQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN 513
              Q   D Q      ++  +QL  +   A  + +   +  +      + L+G LE  K  
Sbjct: 1598 KTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQ 1657

Query: 514  EEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRK 573
              +  +  ++ + ++++ + + + L    EE      E  +Q R   K     L A + +
Sbjct: 1658 MASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK-RLKGLEAEVLR 1716

Query: 574  EQMKVESLERALQQKNQEIEEL 595
             Q ++ + +RA +Q  Q+ +E+
Sbjct: 1717 LQEELAASDRARRQAQQDRDEM 1738


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 64/295 (21%), Positives = 121/295 (41%), Gaps = 13/295 (4%)

Query: 320  GQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKE--TCQKMEEDGSTVLG 377
            G+   G   + E  E L+  +     VS   +   S    + KE  + +    D   +L 
Sbjct: 1283 GRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1342

Query: 378  LLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETR 437
              E+ A+ A  S     E+   G+     ++ A       E+ T + + +EW+++ EE  
Sbjct: 1343 E-ETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1401

Query: 438  QEVL---EMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLS 494
              +    E R+  A   + + Q + ++  T    ++  ++L  E + A  DL    + +S
Sbjct: 1402 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1461

Query: 495  DLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKI-HAEEKLDKANEEI 553
             L ++      +L   ++    L+   +   A  +  E+  +AL +  A E+  +A EE+
Sbjct: 1462 TLEKKQRKFDQLLA--EEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1519

Query: 554  AQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL----TKICDELIA 604
             +     +AE  AL +        V  LERA +   Q   +L    T++ DEL A
Sbjct: 1520 ERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1574



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/214 (24%), Positives = 96/214 (44%), Gaps = 37/214 (17%)

Query: 428  EWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTME--------K 479
            E+  +  E  ++V  + K+  +YE TIA M ED  R     ++  ++L           +
Sbjct: 1027 EFSSQAAEEEEKVKSLNKLRLKYEATIADM-EDRLRKEEKGRQELEKLKRRLDGESSELQ 1085

Query: 480  EQALADLNSVERSLSDLFRRYENLKG--------------VLEGFKKNEEALKKCAQDY- 524
            EQ +      E   + L R+ E L+               +L+  ++ + AL +  +D  
Sbjct: 1086 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1145

Query: 525  ---LARVKQEEQR------YQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQ 575
               +AR K E+QR       +AL+   E+ LD  N +  ++R+K + E   L   L +E 
Sbjct: 1146 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEET 1204

Query: 576  MKVESLERALQQKN-QEIEELTKICDELIAKLGK 608
               E+  + L+Q++ Q + EL +  ++  A+ GK
Sbjct: 1205 RIHEAAVQELRQRHGQALGELAEQLEQ--ARRGK 1236



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 76/377 (20%), Positives = 144/377 (38%), Gaps = 42/377 (11%)

Query: 254  NEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHAT---- 309
            +E+ E   + + R      ++ + E +  A  A + DEG   +Q+   S R+  A     
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK-SLREAQAALAEA 1140

Query: 310  ----DEEKLASTSCGQ--KSAGAEV---KGEPEEDLEYFECSNVPVSTINHAFSSSEAGI 360
                + E++A T   +  +  G E+   +GE E+ L+         S      +  +  +
Sbjct: 1141 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1200

Query: 361  EKET------CQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTL 414
            E+ET       Q++ +     LG L    E+A       G+   +   L+   + + L  
Sbjct: 1201 EEETRIHEAAVQELRQRHGQALGELAEQLEQAR-----RGKGAWEKTRLALEAEVSELRA 1255

Query: 415  IREEIITKEIEANEWKKKYEETRQEVL---------------EMRKIVAEYEKTIAQMIE 459
                + T   E  + +++ E   QEV                ++++  AE E     + E
Sbjct: 1256 ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNE 1315

Query: 460  DEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKK 519
             E +T   S K       +   A   L    R+   L  R   ++    G ++  E  + 
Sbjct: 1316 AESKTIRLS-KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE-EA 1373

Query: 520  CAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVE 579
             A++   R  Q  Q   +     +E+   A E   + R +A  E+ AL   L ++   V+
Sbjct: 1374 AARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVD 1433

Query: 580  SLERALQQKNQEIEELT 596
             LER  ++  QE+++ T
Sbjct: 1434 RLERGRRRLQQELDDAT 1450



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 33/168 (19%)

Query: 469  QKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDY---- 524
            ++  ++    +E+A  +L + +  LS+  RR E   G LE     EEA ++ A++     
Sbjct: 1366 REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA---GEEARRRAAREAEALT 1422

Query: 525  --LARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTK---------------AKAESAAL 567
              LA   +   R +  +   +++LD A  ++ Q R                 A+ ++A L
Sbjct: 1423 QRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1482

Query: 568  HAGLRKEQMKVE---------SLERALQQKNQEIEELTKICDELIAKL 606
             A   +E+ + E         SL RAL+++ +  EEL +    L A+L
Sbjct: 1483 RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1530



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 41/159 (25%), Positives = 83/159 (52%), Gaps = 14/159 (8%)

Query: 442  EMRKIVAEYEKT--IAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRR 499
            ++ K V E E+   +A+   ++ R  +T  +   +LT  ++  L     +E ++  L  +
Sbjct: 1539 DVGKSVHELERACRVAEQAANDLRAQVTELED--ELTAAEDAKLR----LEVTVQALKTQ 1592

Query: 500  YE-NLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQ-ALKIHAEEKLDKANEEI-AQV 556
            +E +L+G  E  ++    L K  +D  A V+++E+R Q  L + A +KL+   EE+ AQ+
Sbjct: 1593 HERDLQGRDEAGEERRRQLAKQLRD--AEVERDEERKQRTLAVAARKKLEGELEELKAQM 1650

Query: 557  RTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEEL 595
             +  + +  A+   LRK Q +++ L R +++     EE+
Sbjct: 1651 ASAGQGKEEAVKQ-LRKMQAQMKELWREVEETRTSREEI 1688



 Score = 29.6 bits (65), Expect = 8.5
 Identities = 36/202 (17%), Positives = 79/202 (39%), Gaps = 5/202 (2%)

Query: 398  LDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTI--- 454
            L+ +  S+ D    +  +       E  AN+ + +  E   E+          E T+   
Sbjct: 1530 LEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQAL 1589

Query: 455  -AQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKN 513
              Q   D Q      ++  +QL  +   A  + +   +  +      + L+G LE  K  
Sbjct: 1590 KTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQ 1649

Query: 514  EEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRK 573
              +  +  ++ + ++++ + + + L    EE      E  +Q R   K     L A + +
Sbjct: 1650 MASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK-RLKGLEAEVLR 1708

Query: 574  EQMKVESLERALQQKNQEIEEL 595
             Q ++ + +RA +Q  Q+ +E+
Sbjct: 1709 LQEELAASDRARRQAQQDRDEM 1730


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.125    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,856,066
Number of Sequences: 37866
Number of extensions: 1214226
Number of successful extensions: 7350
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 708
Number of HSP's that attempted gapping in prelim test: 5328
Number of HSP's gapped (non-prelim): 2250
length of query: 610
length of database: 18,247,518
effective HSP length: 108
effective length of query: 502
effective length of database: 14,157,990
effective search space: 7107310980
effective search space used: 7107310980
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.