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Search of human proteins with 223890246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223890246 muskelin 1, intracellular mediator containing
kelch motifs isoform 1 [Homo sapiens]
(712 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223890246 muskelin 1, intracellular mediator containing kelch... 1489 0.0
gi|31881798 muskelin 1, intracellular mediator containing kelch ... 1470 0.0
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 57 6e-08
gi|21450863 attractin isoform 2 [Homo sapiens] 51 4e-06
gi|21450861 attractin isoform 1 [Homo sapiens] 51 4e-06
gi|46410931 attractin-like 1 [Homo sapiens] 48 4e-05
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 43 0.001
gi|11056006 kelch-like 12 [Homo sapiens] 42 0.002
gi|26190616 kelch domain containing 1 [Homo sapiens] 42 0.002
gi|21314675 kelch domain containing 4 [Homo sapiens] 40 0.006
gi|40018614 DRE1 protein [Homo sapiens] 40 0.007
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 39 0.013
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 39 0.013
gi|34101268 kelch-like 8 [Homo sapiens] 39 0.013
gi|166235129 kelch-like 3 [Homo sapiens] 39 0.022
gi|14780904 kelch-like 1 protein [Homo sapiens] 38 0.037
gi|38194229 kelch-like 17 [Homo sapiens] 36 0.11
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 35 0.24
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 35 0.24
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 35 0.24
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 34 0.41
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 34 0.41
gi|24308181 kelch-like 9 [Homo sapiens] 34 0.41
gi|7657301 kelch domain containing 2 [Homo sapiens] 34 0.41
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 33 0.70
gi|40807500 kelch-like 20 [Homo sapiens] 33 0.70
gi|45643138 kelch-like 13 [Homo sapiens] 33 0.92
gi|8922640 kelch domain containing 8A [Homo sapiens] 33 0.92
gi|171543895 ataxin 2 [Homo sapiens] 33 1.2
gi|55956890 kelch/ankyrin repeat containing cyclin A1 interactin... 33 1.2
>gi|223890246 muskelin 1, intracellular mediator containing kelch
motifs isoform 1 [Homo sapiens]
Length = 712
Score = 1489 bits (3856), Expect = 0.0
Identities = 712/712 (100%), Positives = 712/712 (100%)
Query: 1 MLENMGIGIRNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCN 60
MLENMGIGIRNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCN
Sbjct: 1 MLENMGIGIRNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCN 60
Query: 61 LKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSF 120
LKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSF
Sbjct: 61 LKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSF 120
Query: 121 NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIA 180
NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIA
Sbjct: 121 NFSIWYVELSGIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIA 180
Query: 181 LEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDG 240
LEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDG
Sbjct: 181 LEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDG 240
Query: 241 EDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGP 300
EDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGP
Sbjct: 241 EDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGP 300
Query: 301 SARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
SARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG
Sbjct: 301 SARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
Query: 361 PKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLRE 420
PKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLRE
Sbjct: 361 PKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLRE 420
Query: 421 DSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTK 480
DSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTK
Sbjct: 421 DSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTK 480
Query: 481 KDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYK 540
KDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYK
Sbjct: 481 KDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYK 540
Query: 541 NDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKL 600
NDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKL
Sbjct: 541 NDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKL 600
Query: 601 CRPSKDYLLRHCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLAS 660
CRPSKDYLLRHCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLAS
Sbjct: 601 CRPSKDYLLRHCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLAS 660
Query: 661 ALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL 712
ALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL
Sbjct: 661 ALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL 712
>gi|31881798 muskelin 1, intracellular mediator containing kelch
motifs isoform 2 [Homo sapiens]
Length = 735
Score = 1470 bits (3806), Expect = 0.0
Identities = 702/702 (100%), Positives = 702/702 (100%)
Query: 11 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGM 70
NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGM
Sbjct: 34 NILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGM 93
Query: 71 NEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELS 130
NEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELS
Sbjct: 94 NEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELS 153
Query: 131 GIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDIH 190
GIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDIH
Sbjct: 154 GIDDPDIVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDIH 213
Query: 191 DKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGG 250
DKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGG
Sbjct: 214 DKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGG 273
Query: 251 HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCI 310
HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCI
Sbjct: 274 HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCI 333
Query: 311 DIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMC 370
DIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMC
Sbjct: 334 DIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMC 393
Query: 371 MDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDI 430
MDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDI
Sbjct: 394 MDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDI 453
Query: 431 QSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTG 490
QSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTG
Sbjct: 454 QSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTG 513
Query: 491 FTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPT 550
FTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPT
Sbjct: 514 FTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPT 573
Query: 551 KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLR 610
KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLR
Sbjct: 574 KSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLR 633
Query: 611 HCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFT 670
HCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFT
Sbjct: 634 HCKYLIRKHRFEEKAQVDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFT 693
Query: 671 ALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL 712
ALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL
Sbjct: 694 ALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL 735
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 57.0 bits (136), Expect = 6e-08
Identities = 80/327 (24%), Positives = 124/327 (37%), Gaps = 62/327 (18%)
Query: 198 DFD-ACEELIEK-AVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVI 255
DFD +C + +E +N G F E RW ++ P D G R V+
Sbjct: 29 DFDHSCSDSVEYLTLNFGPF-------ETVHRWRRLPPC-------DEFVGARRSKHTVV 74
Query: 256 DVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRR 315
+ + +Y+FGG +G L D + VK+ W C + T P A H + +
Sbjct: 75 AYK-DAIYVFGGDNGKTMLNDLLRFDVKDCSW-CRAFTT---GTPPAPRYHHSAV-VYGS 128
Query: 316 QIYTLGRYLDSSVRNSK-SLKSDFYRYDIDTNTWMLLSED----TAADGGPKLVFDHQMC 370
++ G Y NS K+D + Y T W + A V+ ++
Sbjct: 129 SMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLW 188
Query: 371 M------DSEKHMIYTFG--GRILTCNGSVDDSRASEPQ---------------FSG--- 404
+ ++ + ++T G R LTC V S P FSG
Sbjct: 189 IFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSG 248
Query: 405 ------LFAFNCQCQTW-KLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKT 457
LF F + +TW ++ E P Q R GH M+ + +R LYVFGG T
Sbjct: 249 AKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMV--AFDRHLYVFGGAADNT 306
Query: 458 YLNDFFSYDVDSDHVDIISDGTKKDSG 484
N+ YDVD +++ + + G
Sbjct: 307 LPNELHCYDVDFQTWEVVQPSSDSEVG 333
>gi|21450863 attractin isoform 2 [Homo sapiens]
Length = 1272
Score = 50.8 bits (120), Expect = 4e-06
Identities = 45/176 (25%), Positives = 69/176 (39%), Gaps = 21/176 (11%)
Query: 280 YSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFY 339
Y + +N W+ + G H D + R +Y G Y S N L D Y
Sbjct: 480 YDLDKNTWSILHTQGALVQGGYG---HSSVYDHRTRALYVHGGYKAFSA-NKYRLADDLY 535
Query: 340 RYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASE 399
RYD+DT W +L + + H + S ++ FGG + S ++
Sbjct: 536 RYDVDTQMWTILKDSRF------FRYLHTAVIVSGTMLV--FGG---NTHNDTSMSHGAK 584
Query: 400 PQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRS 455
S A++ C W +L + D+ +R GH + H N +YVFGG S
Sbjct: 585 CFSSDFMAYDIACDRWSVLPRPDLH---HDV-NRFGHSAVLH--NSTMYVFGGFNS 634
Score = 38.9 bits (89), Expect = 0.017
Identities = 47/245 (19%), Positives = 94/245 (38%), Gaps = 40/245 (16%)
Query: 243 NRPGMRGGHQMVIDVQTETVYLFGGW-DGTQDLA-DFWAYSVKENQWTCISRDTEKENGP 300
N +R GH + + + +Y++GG D T ++ + + + W ++ +++
Sbjct: 387 NNVVVRYGHSLAL--YKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAV 444
Query: 301 SARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLL-SEDTAADG 359
S H + + R + + + S+ YD+D NTW +L ++ G
Sbjct: 445 VGHSAHIVTLKNGRVVMLVIFGHCPLY-----GYISNVQEYDLDKNTWSILHTQGALVQG 499
Query: 360 GPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLR 419
G + H D +Y GG S + R ++ L+ ++ Q W +L+
Sbjct: 500 G----YGHSSVYDHRTRALYVHGGYKAF---SANKYRLAD----DLYRYDVDTQMWTILK 548
Query: 420 EDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQR---------SKTYLNDFFSYDVDSD 470
+ R H + S + VFGG +K + +DF +YD+ D
Sbjct: 549 DSRF--------FRYLHTAVIVSGT--MLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACD 598
Query: 471 HVDII 475
++
Sbjct: 599 RWSVL 603
>gi|21450861 attractin isoform 1 [Homo sapiens]
Length = 1429
Score = 50.8 bits (120), Expect = 4e-06
Identities = 45/176 (25%), Positives = 69/176 (39%), Gaps = 21/176 (11%)
Query: 280 YSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFY 339
Y + +N W+ + G H D + R +Y G Y S N L D Y
Sbjct: 480 YDLDKNTWSILHTQGALVQGGYG---HSSVYDHRTRALYVHGGYKAFSA-NKYRLADDLY 535
Query: 340 RYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASE 399
RYD+DT W +L + + H + S ++ FGG + S ++
Sbjct: 536 RYDVDTQMWTILKDSRF------FRYLHTAVIVSGTMLV--FGG---NTHNDTSMSHGAK 584
Query: 400 PQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRS 455
S A++ C W +L + D+ +R GH + H N +YVFGG S
Sbjct: 585 CFSSDFMAYDIACDRWSVLPRPDLH---HDV-NRFGHSAVLH--NSTMYVFGGFNS 634
Score = 38.9 bits (89), Expect = 0.017
Identities = 47/245 (19%), Positives = 94/245 (38%), Gaps = 40/245 (16%)
Query: 243 NRPGMRGGHQMVIDVQTETVYLFGGW-DGTQDLA-DFWAYSVKENQWTCISRDTEKENGP 300
N +R GH + + + +Y++GG D T ++ + + + W ++ +++
Sbjct: 387 NNVVVRYGHSLAL--YKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAV 444
Query: 301 SARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLL-SEDTAADG 359
S H + + R + + + S+ YD+D NTW +L ++ G
Sbjct: 445 VGHSAHIVTLKNGRVVMLVIFGHCPLY-----GYISNVQEYDLDKNTWSILHTQGALVQG 499
Query: 360 GPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLR 419
G + H D +Y GG S + R ++ L+ ++ Q W +L+
Sbjct: 500 G----YGHSSVYDHRTRALYVHGGYKAF---SANKYRLAD----DLYRYDVDTQMWTILK 548
Query: 420 EDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQR---------SKTYLNDFFSYDVDSD 470
+ R H + S + VFGG +K + +DF +YD+ D
Sbjct: 549 DSRF--------FRYLHTAVIVSGT--MLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACD 598
Query: 471 HVDII 475
++
Sbjct: 599 RWSVL 603
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 47.8 bits (112), Expect = 4e-05
Identities = 55/239 (23%), Positives = 89/239 (37%), Gaps = 24/239 (10%)
Query: 228 WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDL-ADFWAYSVKENQ 286
WS P + G G+ H M +D + + + G+ + Y + N
Sbjct: 395 WSTKTP-TVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNT 453
Query: 287 WTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTN 346
W G H D + IY G Y + N L D Y+Y+++T
Sbjct: 454 WLVPETKGAIVQGGYG---HTSVYDEITKSIYVHGGY-KALPGNKYGLVDDLYKYEVNTK 509
Query: 347 TWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLF 406
TW +L E A + H + + +I FGG + ++ F
Sbjct: 510 TWTILKESGFAR------YLHSAVLINGAMLI--FGGNTHNDTSLSNGAKCFSADF---L 558
Query: 407 AFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSY 465
A++ C WK+L + + + D+ +R GH + N +Y+FGG S LND Y
Sbjct: 559 AYDIACDEWKILPKPNLH---RDV-NRFGHSAVV--INGSMYIFGG-FSSVLLNDILVY 610
Score = 37.0 bits (84), Expect = 0.063
Identities = 46/243 (18%), Positives = 92/243 (37%), Gaps = 41/243 (16%)
Query: 341 YDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEP 400
Y+++++ W + + GP + H + + E I+ +GGRI T +G+V D
Sbjct: 336 YNLESSIWNVGTPSR----GPLQRYGHSLALYQEN--IFMYGGRIETNDGNVTDE----- 384
Query: 401 QFSGLFAFNCQCQTWKLLREDSCNAGPE-DIQSRIGHCMLFHSKN-RCLYVFGGQRSKTY 458
L+ FN Q+W G + ++ H M S++ + +FG Y
Sbjct: 385 ----LWVFNIHSQSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGY 440
Query: 459 LNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKRE 518
+ Y + S+ + + G + G+ + D I+V G K +
Sbjct: 441 TSSIQEYHISSNTWLV-----PETKGAIVQGGYGHTSVYDEITKSIYVHGGY-KALPGNK 494
Query: 519 ENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPTKSLQEEEPCPRFAHQLVYDELHKVHYLF 578
+ + + Y++ +W ++ +E R+ H V ++ +F
Sbjct: 495 YGLVDDLYKYEVNTKTW----------------TILKESGFARYLHSAVL--INGAMLIF 536
Query: 579 GGN 581
GGN
Sbjct: 537 GGN 539
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 42.7 bits (99), Expect = 0.001
Identities = 57/216 (26%), Positives = 79/216 (36%), Gaps = 36/216 (16%)
Query: 264 LFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRY 323
+FGG D L D Y+ N W + P+AR H + + + G
Sbjct: 244 VFGGQDLNNALGDLVLYNFSANTW----ESWDLSPAPAARHSH-VAVAWAGSLVLMGGEL 298
Query: 324 LDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGG 383
D S+ N S R W LL+ ++ GP + H + + +Y GG
Sbjct: 299 ADGSLTNDVWAFSPLGR-----GHWELLAPPASSSSGPPGLAGHAAALVDDV-WLYVSGG 352
Query: 384 RILTCNGSVDDSRASEPQFSGLFAFNCQCQT---WKLLREDSCNAGPEDIQSRIGHCMLF 440
R + SGLF F + W E AG + GH M+F
Sbjct: 353 RT-----------PHDLFSSGLFRFRLDSTSGGYW----EQVIPAGGRP-PAATGHSMVF 396
Query: 441 HSKNRCLYVFGGQRSKTYLNDFFSYDVDSD---HVD 473
H+ +R L V GG R T FS V+S HVD
Sbjct: 397 HAPSRALLVHGGHRPSTAR---FSVRVNSTELFHVD 429
Score = 33.9 bits (76), Expect = 0.54
Identities = 48/216 (22%), Positives = 77/216 (35%), Gaps = 41/216 (18%)
Query: 213 GLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGM--RGGHQMV-IDVQTETVYLFGGWD 269
GL + RW+Q++ ED PG R H + +YL GG
Sbjct: 1467 GLLGNLYRYSVSERRWTQML-----AGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLT 1521
Query: 270 GTQDLADFWAYSVKENQWTCISRDTEKENGPS-----ARSCHKMCIDIQRRQIYTLGRYL 324
DFW ++ QW +E P A + H + + + +G Y
Sbjct: 1522 AGGVTRDFWVLNLTTLQW-------RQEKAPQTVELPAVAGHTLTAR-RGLSLLLVGGYS 1573
Query: 325 DSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG--PKLVFDHQMCMDSEKHMIYTFG 382
+ N + L+ Y + T TW+ + A G P ++ H +Y FG
Sbjct: 1574 PENGFNQQLLE-----YQLATGTWV-----SGAQSGTPPTGLYGHSAVYHEATDSLYVFG 1623
Query: 383 GRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLL 418
G + A P+ L++ +C +TW LL
Sbjct: 1624 GFRFHV-----ELAAPSPE---LYSLHCPDRTWSLL 1651
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/144 (23%), Positives = 64/144 (44%), Gaps = 30/144 (20%)
Query: 212 DGLFNQYISQQEYKPR---WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGW 268
DGL N S ++Y P W+ + P +TK G + + + +Y+ GG+
Sbjct: 435 DGL-NILNSVEKYDPHTGHWTNVTPMATKRSGAG------------VALLNDHIYVVGGF 481
Query: 269 DGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSV 328
DGT L+ AY+++ + WT ++ T C+ + + R ++Y + Y
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPR-------CY-VGATVLRGRLYAIAGY----- 528
Query: 329 RNSKSLKSDFYRYDIDTNTWMLLS 352
+ SL S YD ++W +++
Sbjct: 529 -DGNSLLSSIECYDPIIDSWEVVT 551
Score = 32.0 bits (71), Expect = 2.0
Identities = 35/172 (20%), Positives = 62/172 (36%), Gaps = 42/172 (24%)
Query: 187 TDIHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKP---RWSQIIPKSTKGDGEDN 243
T + D + + G FD ++ S + Y P +WS + GD +
Sbjct: 375 TTLGDMIYVSGGFDGSR-------------RHTSMERYDPNIDQWSML------GDMQTA 415
Query: 244 RPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSAR 303
R G + V + +Y GG+DG L Y WT ++ K +G
Sbjct: 416 REGAG------LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAG-- 467
Query: 304 SCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDT 355
+ + IY +G + + + S Y+I T++W ++ T
Sbjct: 468 ------VALLNDHIYVVGGF------DGTAHLSSVEAYNIRTDSWTTVTSMT 507
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 42.4 bits (98), Expect = 0.002
Identities = 73/311 (23%), Positives = 121/311 (38%), Gaps = 59/311 (18%)
Query: 248 RGGHQMVIDVQTETVYLFGGWDGTQDLA------DFWAYSVKENQWTCISRDTEKENGPS 301
R GH V+D +Y++GG+ +D + W Y + W + E S
Sbjct: 13 RSGHCAVVD--GNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMS 70
Query: 302 ARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGP 361
SC CI+ ++Y G Y D N + R +T W +++ +G P
Sbjct: 71 G-SCGA-CIN---GKLYIFGGYDDKGYSNRLYFVN--LRTRDETYIWEKITD---FEGQP 120
Query: 362 KLVFDHQMCMDSEKHMIYTFGG-------RILTCNGSVDDSRASEPQFSG----LFAFNC 410
D C + +IY FGG + C V D+ E F G + F+
Sbjct: 121 PTPRDKLSCWVYKDRLIY-FGGYGCRRHSELQDCF-DVHDASWEEQIFWGWHNDVHIFDT 178
Query: 411 QCQTWKLLREDSCNAGPEDIQSRIGH-CMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDS 469
+ QTW + + P Q R H C + +K Y+FGG+ +T +ND ++D
Sbjct: 179 KTQTW--FQPEIKGGVPP--QPRAAHTCAVLGNKG---YIFGGRVLQTRMNDLHYLNLD- 230
Query: 470 DHVDIISDGTKKDSGMVPMTGFTQR----ATIDPELNE-IHVLSGLSKDKEKREENVRNS 524
T SG + + G + + T+ P ++ + + GLS D +
Sbjct: 231 ---------TWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDG---- 277
Query: 525 FWIYDIVRNSW 535
WI+++ N W
Sbjct: 278 -WIHNVTTNCW 287
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 40.4 bits (93), Expect = 0.006
Identities = 62/311 (19%), Positives = 111/311 (35%), Gaps = 49/311 (15%)
Query: 245 PGMRGGHQMVIDVQTETVYLFGG--WDGTQDLA--DFWAYSVKENQWTCISRDTEKENGP 300
P R + + + + + LFGG ++G + + + Y+ +++ WT + + P
Sbjct: 61 PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPS-----P 115
Query: 301 SARSCHKMCIDIQRR--QIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAAD 358
R C + + + Q++ G S D + + T TW E +
Sbjct: 116 PPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTW----EQVKST 171
Query: 359 GGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLL 418
GGP H+M + K + FGG +S ++ ++AFN TW L
Sbjct: 172 GGPSGRSGHRMV--AWKRQLILFGG--------FHESTRDYIYYNDVYAFNLDTFTWSKL 221
Query: 419 REDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDG 478
P C + + + V+GG + D SD + +
Sbjct: 222 SPSGTGPTPRS------GCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPED 275
Query: 479 TKKD---------SGM--VPMTGFTQRATIDPELNEIHVLSGLSKDKEKREE---NVRNS 524
++D SG+ P +GF+ + N + G D+E+ E N
Sbjct: 276 GREDKWVWTRMNPSGVKPTPRSGFS----VAMAPNHQTLFFGGVCDEEEEESLSGEFFND 331
Query: 525 FWIYDIVRNSW 535
+ YD RN W
Sbjct: 332 LYFYDATRNRW 342
Score = 39.7 bits (91), Expect = 0.010
Identities = 39/147 (26%), Positives = 61/147 (41%), Gaps = 25/147 (17%)
Query: 214 LFNQYISQQEYKPRWSQI-IPKSTKGDGEDNRPGMRGGHQMVIDVQTE-TVYLFGGW--- 268
L+N+ K W+++ IP P R HQ V+ Q +++FGG
Sbjct: 93 LYNELYVYNTRKDTWTKVDIPSP---------PPRRCAHQAVVVPQGGGQLWVFGGEFAS 143
Query: 269 -DGTQ--DLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLD 325
+G Q D W + W + GPS RS H+M +RQ+ G + +
Sbjct: 144 PNGEQFYHYKDLWVLHLATKTW----EQVKSTGGPSGRSGHRMVA--WKRQLILFGGFHE 197
Query: 326 SSVRNSKSLKSDFYRYDIDTNTWMLLS 352
S+ +D Y +++DT TW LS
Sbjct: 198 ST--RDYIYYNDVYAFNLDTFTWSKLS 222
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 40.0 bits (92), Expect = 0.007
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 27/137 (19%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
VY+ GG+DG L+ Y N+WT ++ E + P+ SC +++ +G
Sbjct: 409 VYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC--------VGKLFVIG 460
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMD--SEKHMIY 379
D + + K YD +TN+W+L + A + C+ S ++IY
Sbjct: 461 GGPDDNTCSDK-----VQSYDPETNSWLLRAAIPIA----------KRCITAVSLNNLIY 505
Query: 380 TFGG--RILTCNGSVDD 394
GG + + C V+D
Sbjct: 506 VAGGLTKAIYCYDPVED 522
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/109 (24%), Positives = 44/109 (40%), Gaps = 14/109 (12%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DG L Y V+ WT ++ P + I + + +IY LG
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVA--------PMKHRRSALGITVHQGRIYVLG 570
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMC 370
Y + +S YD DT+TW ++ T+ G + + C
Sbjct: 571 GYDGHTFLDSVEC------YDPDTDTWSEVTRMTSGRSGVGVAVTMEPC 613
Score = 38.9 bits (89), Expect = 0.017
Identities = 33/136 (24%), Positives = 49/136 (36%), Gaps = 29/136 (21%)
Query: 220 SQQEYKPR---WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLAD 276
S + Y+P W + P T+ G + + V +Y GG+DGT L
Sbjct: 439 SVERYEPERDEWHLVAPMLTRRIG------------VGVAVLNRLLYAVGGFDGTNRLNS 486
Query: 277 FWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKS 336
Y + N+W I+ +G H IY G Y NS
Sbjct: 487 AECYYPERNEWRMITAMNTIRSGAGVCVLHNC--------IYAAGGYDGQDQLNSVE--- 535
Query: 337 DFYRYDIDTNTWMLLS 352
RYD++T TW ++
Sbjct: 536 ---RYDVETETWTFVA 548
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/109 (24%), Positives = 44/109 (40%), Gaps = 14/109 (12%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DG L Y V+ WT ++ P + I + + +IY LG
Sbjct: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVA--------PMKHRRSALGITVHQGRIYVLG 570
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMC 370
Y + +S YD DT+TW ++ T+ G + + C
Sbjct: 571 GYDGHTFLDSVEC------YDPDTDTWSEVTRMTSGRSGVGVAVTMEPC 613
Score = 38.9 bits (89), Expect = 0.017
Identities = 33/136 (24%), Positives = 49/136 (36%), Gaps = 29/136 (21%)
Query: 220 SQQEYKPR---WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLAD 276
S + Y+P W + P T+ G + + V +Y GG+DGT L
Sbjct: 439 SVERYEPERDEWHLVAPMLTRRIG------------VGVAVLNRLLYAVGGFDGTNRLNS 486
Query: 277 FWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKS 336
Y + N+W I+ +G H IY G Y NS
Sbjct: 487 AECYYPERNEWRMITAMNTIRSGAGVCVLHNC--------IYAAGGYDGQDQLNSVE--- 535
Query: 337 DFYRYDIDTNTWMLLS 352
RYD++T TW ++
Sbjct: 536 ---RYDVETETWTFVA 548
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 39.3 bits (90), Expect = 0.013
Identities = 56/238 (23%), Positives = 89/238 (37%), Gaps = 45/238 (18%)
Query: 248 RGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHK 307
R H VI V+ + VY GG DG + L + N+W + K G + S
Sbjct: 355 RRRHVGVISVEGK-VYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASL-- 411
Query: 308 MCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDH 367
IY +G D++ N D RYDI+++ W ++ GG V
Sbjct: 412 ------GGPIYAIGGLDDNTCFN------DVERYDIESDQWSTVAPMNTPRGGVGSV--- 456
Query: 368 QMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGP 427
+ + +Y GG +D AS S + ++ W ++E
Sbjct: 457 -----ALVNHVYAVGG---------NDGMAS---LSSVERYDPHLDKWIEVKEMG----- 494
Query: 428 EDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGM 485
Q R G+ + + CLYV GG + L+ YD S+ D ++ T G+
Sbjct: 495 ---QRRAGNGV--SKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGV 547
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 38.5 bits (88), Expect = 0.022
Identities = 25/104 (24%), Positives = 47/104 (45%), Gaps = 12/104 (11%)
Query: 257 VQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQ 316
V + +Y GG+DG+ LA AYS K N+W ++ P + + + +
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVA--------PMNTRRSSVGVGVVEGK 442
Query: 317 IYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
+Y +G Y + S+ S +Y+ TN W+ +++ + G
Sbjct: 443 LYAVGGYDGA----SRQCLSTVEQYNPATNEWIYVADMSTRRSG 482
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 37.7 bits (86), Expect = 0.037
Identities = 70/337 (20%), Positives = 123/337 (36%), Gaps = 80/337 (23%)
Query: 185 MLTDIHDKLVLKGDFDACEELIEKAVNDGLFNQ---YISQQEYKPRWSQIIPKSTKGDGE 241
+L D+ + + K D + C++LI +A+ L + + KPR S + G +
Sbjct: 410 ILADLENHALFKNDLE-CQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMD 468
Query: 242 DNR-----------------PGMRGGHQMVIDVQT--ETVYLFGGWDGTQDLADFWAYSV 282
+N+ GM G ++ V + +++ GG DG + L Y+
Sbjct: 469 NNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNP 528
Query: 283 KENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYD 342
K WT + P + H + + + IY +G + S N+ R+D
Sbjct: 529 KTKTWTVLP--------PMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVE------RWD 574
Query: 343 IDTNTWMLLSEDTAADGGPKLVF-----------DHQMCMDSEKH-------------MI 378
+ W ++ + A + D C+ S ++ M
Sbjct: 575 PQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMC 634
Query: 379 YTFGG-RILTCNGSV-----DDSRASEP---QFSGLFAFNCQCQTWKLLREDSCNAGPED 429
GG + TC+G + D+ AS + ++ + TW ++ S P D
Sbjct: 635 KRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSM---PRD 691
Query: 430 IQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYD 466
+G C+L LY GG +TYLN SYD
Sbjct: 692 A---VGVCLLGDR----LYAVGGYDGQTYLNTMESYD 721
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 36.2 bits (82), Expect = 0.11
Identities = 29/87 (33%), Positives = 38/87 (43%), Gaps = 14/87 (16%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DGT DLA +Y N W E G + RSC + + +Y+ G
Sbjct: 391 LYAVGGYDGTSDLATVESYDPVTNTW-----QPEVSMG-TRRSC--LGVAALHGLLYSAG 442
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTW 348
Y +S NS RYD T TW
Sbjct: 443 GYDGASCLNSAE------RYDPLTGTW 463
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 35.0 bits (79), Expect = 0.24
Identities = 23/99 (23%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DG+ L+ AY++K N+W ++ P + + + +Y +G
Sbjct: 314 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVA--------PMNTRRSSVGVGVVGGLLYAVG 365
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
Y + S+ S Y+ TN W ++E + G
Sbjct: 366 GYDGA----SRQCLSTVECYNATTNEWTYIAEMSTRRSG 400
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 35.0 bits (79), Expect = 0.24
Identities = 23/99 (23%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DG+ L+ AY++K N+W ++ P + + + +Y +G
Sbjct: 406 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVA--------PMNTRRSSVGVGVVGGLLYAVG 457
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
Y + S+ S Y+ TN W ++E + G
Sbjct: 458 GYDGA----SRQCLSTVECYNATTNEWTYIAEMSTRRSG 492
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 35.0 bits (79), Expect = 0.24
Identities = 23/99 (23%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG+DG+ L+ AY++K N+W ++ P + + + +Y +G
Sbjct: 402 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVA--------PMNTRRSSVGVGVVGGLLYAVG 453
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGG 360
Y + S+ S Y+ TN W ++E + G
Sbjct: 454 GYDGA----SRQCLSTVECYNATTNEWTYIAEMSTRRSG 488
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 34.3 bits (77), Expect = 0.41
Identities = 37/125 (29%), Positives = 49/125 (39%), Gaps = 24/125 (19%)
Query: 260 ETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYT 319
+ +YL GG + LAD W Y + W +SR T R H + +IYT
Sbjct: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT------VPRCRHNSL--VYDGKIYT 687
Query: 320 LGRY-LDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMI 378
LG + +V + + RYD TN W A PK V + K I
Sbjct: 688 LGGLGVAGNVDHVE-------RYDTITNQW------EAVAPLPKAVHSAAATVCGGK--I 732
Query: 379 YTFGG 383
Y FGG
Sbjct: 733 YVFGG 737
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 34.3 bits (77), Expect = 0.41
Identities = 37/125 (29%), Positives = 49/125 (39%), Gaps = 24/125 (19%)
Query: 260 ETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYT 319
+ +YL GG + LAD W Y + W +SR T R H + +IYT
Sbjct: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT------VPRCRHNSL--VYDGKIYT 687
Query: 320 LGRY-LDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMI 378
LG + +V + + RYD TN W A PK V + K I
Sbjct: 688 LGGLGVAGNVDHVE-------RYDTITNQW------EAVAPLPKAVHSAAATVCGGK--I 732
Query: 379 YTFGG 383
Y FGG
Sbjct: 733 YVFGG 737
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 34.3 bits (77), Expect = 0.41
Identities = 29/138 (21%), Positives = 54/138 (39%), Gaps = 22/138 (15%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG +LA Y+ + N+W+ +++ +E G + +Y
Sbjct: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAG-------------TVYGGL 447
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTF 381
Y+ + + + +++ +D DT+ WM + T G H MC +K +Y
Sbjct: 448 MYISGGITHD-TFQNELMCFDPDTDKWMQKAPMTTVRG------LHCMCTVGDK--LYVI 498
Query: 382 GGRILTCNGSVDDSRASE 399
GG DD + E
Sbjct: 499 GGNHFRGTSDYDDVLSCE 516
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 34.3 bits (77), Expect = 0.41
Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 9/61 (14%)
Query: 228 WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWD-GTQDLADFWAYSVKENQ 286
W+++IP+ G R H + V ++ ++LFGG+ Q L+D W Y + +N+
Sbjct: 255 WNELIPQGICPVG-------RSWHSLT-PVSSDHLFLFGGFTTDKQPLSDAWTYCISKNE 306
Query: 287 W 287
W
Sbjct: 307 W 307
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 33.5 bits (75), Expect = 0.70
Identities = 18/49 (36%), Positives = 22/49 (44%), Gaps = 3/49 (6%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCI 310
VY+FGG L + Y +E WT + DT P R H MCI
Sbjct: 255 VYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLL---PPGRLDHSMCI 300
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 33.5 bits (75), Expect = 0.70
Identities = 28/132 (21%), Positives = 52/132 (39%), Gaps = 29/132 (21%)
Query: 222 QEYKP---RWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFW 278
+ Y P RW I P T+ + V + +Y GG D T +L+
Sbjct: 478 ERYNPQENRWHTIAPMGTRRK------------HLGCAVYQDMIYAVGGRDDTTELSSAE 525
Query: 279 AYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDF 338
Y+ + NQW+ + T + +G + + + Q+ +G + ++ + +
Sbjct: 526 RYNPRTNQWSPVVAMTSRRSG--------VGLAVVNGQLMAVGGFDGTTYLKTIEV---- 573
Query: 339 YRYDIDTNTWML 350
+D D NTW L
Sbjct: 574 --FDPDANTWRL 583
Score = 31.6 bits (70), Expect = 2.7
Identities = 32/130 (24%), Positives = 52/130 (40%), Gaps = 29/130 (22%)
Query: 222 QEYKPR---WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFW 278
+ Y P+ W+++ ST+ G + + V +Y GG DGT L
Sbjct: 431 ERYDPKENKWTRVASMSTRRLG------------VAVAVLGGFLYAVGGSDGTSPLNTVE 478
Query: 279 AYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDF 338
Y+ +EN+W I+ R H C + + IY +G D++ +S
Sbjct: 479 RYNPQENRWHTIA-------PMGTRRKHLGCA-VYQDMIYAVGGRDDTTELSSAE----- 525
Query: 339 YRYDIDTNTW 348
RY+ TN W
Sbjct: 526 -RYNPRTNQW 534
Score = 31.2 bits (69), Expect = 3.5
Identities = 20/89 (22%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 260 ETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYT 319
E ++ GGW ++ Y + N+W ++ +++ G + + + +Y
Sbjct: 318 EVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCG--------VGVSVLDDLLYA 369
Query: 320 LGRYLDSSVRNSKSLKSDFYRYDIDTNTW 348
+G + SS NS RYD TN W
Sbjct: 370 VGGHDGSSYLNSVE------RYDPKTNQW 392
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 33.1 bits (74), Expect = 0.92
Identities = 28/138 (20%), Positives = 53/138 (38%), Gaps = 22/138 (15%)
Query: 262 VYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLG 321
+Y GG + +L Y+ + N+WT +++ +E G + +Y
Sbjct: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAG-------------TVYGGV 489
Query: 322 RYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTF 381
Y+ + + + + + +D DT+ W+ + T G H MC E+ +Y
Sbjct: 490 MYISGGITHD-TFQKELMCFDPDTDKWIQKAPMTTVRG------LHCMCTVGER--LYVI 540
Query: 382 GGRILTCNGSVDDSRASE 399
GG DD + E
Sbjct: 541 GGNHFRGTSDYDDVLSCE 558
>gi|8922640 kelch domain containing 8A [Homo sapiens]
Length = 350
Score = 33.1 bits (74), Expect = 0.92
Identities = 58/275 (21%), Positives = 103/275 (37%), Gaps = 53/275 (19%)
Query: 262 VYLFGGWDGTQDLAD-FWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTL 320
VY GG D D F YS + +QWT + R P+AR+ + + ++I +
Sbjct: 33 VYAIGGCDDNGVPMDCFEVYSPEADQWTALPRL------PTARA--GVAVTALGKRIMVI 84
Query: 321 GRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYT 380
G V ++ Y+ID W S A G + + ++ + +Y
Sbjct: 85 G-----GVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMG--------ISVTAKDYRVYA 131
Query: 381 FGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLF 440
GG L D R Q + +L++ + P L
Sbjct: 132 AGGMGL-------DLRPHN-----------HLQHYDMLKDMWVSLAPMPTPRYAATSFLR 173
Query: 441 HSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPE 500
SK +YV GG++SK +N F +D++ + K + F+ T+D
Sbjct: 174 GSK---IYVLGGRQSKYAVNAFEVFDIE-------TRSWTKFPNIPYKRAFSSFVTLD-- 221
Query: 501 LNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSW 535
N ++ L GL + + R+ + ++D+ + W
Sbjct: 222 -NHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGW 255
>gi|171543895 ataxin 2 [Homo sapiens]
Length = 1313
Score = 32.7 bits (73), Expect = 1.2
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 639 DLYITVDHSDPEET----KEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVN 693
DL + H E+ K +++ S LFK SDF + F D+D +YA+R D+ ++
Sbjct: 302 DLVLDAAHEKSTESSSGPKREEIMESILFKC-SDFVVVQFKDMDSSYAKRDAFTDSAIS 359
>gi|55956890 kelch/ankyrin repeat containing cyclin A1 interacting
protein isoform b [Homo sapiens]
Length = 288
Score = 32.7 bits (73), Expect = 1.2
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 6/87 (6%)
Query: 240 GEDNRPGMRGG----HQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTE 295
G+ R G RG H V + + GGWDG++ LA A + W + T
Sbjct: 66 GQAVRLGARGSPPRSHHDAAPVDGRWLCVVGGWDGSRRLATVTALDTERGVWEAWT-GTP 124
Query: 296 KENGPSARSCHKMCIDIQRRQIYTLGR 322
+ P+ S H C I R++ GR
Sbjct: 125 GDCPPAGLSSH-TCTRISDRELQVAGR 150
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,107,618
Number of Sequences: 37866
Number of extensions: 1351291
Number of successful extensions: 2722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 143
length of query: 712
length of database: 18,247,518
effective HSP length: 109
effective length of query: 603
effective length of database: 14,120,124
effective search space: 8514434772
effective search space used: 8514434772
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.