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Search of human proteins with 223646115
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223646115 short chain dehydrogenase/reductase family 16C,
member 6 [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 650 0.0
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 352 3e-97
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 238 5e-63
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 216 2e-56
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 215 4e-56
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 186 2e-47
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 174 7e-44
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 79 4e-15
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 78 9e-15
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 70 3e-12
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 69 6e-12
gi|40254992 carbonic reductase 4 [Homo sapiens] 68 1e-11
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 67 2e-11
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 67 2e-11
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 65 1e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 64 1e-10
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 62 7e-10
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 62 9e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 61 2e-09
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 60 2e-09
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 59 4e-09
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 58 1e-08
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 54 1e-07
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 54 1e-07
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 53 3e-07
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 53 4e-07
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 53 4e-07
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 51 1e-06
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 50 2e-06
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 49 8e-06
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 650 bits (1677), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG
Sbjct: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
Query: 61 AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN
Sbjct: 61 AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI
Sbjct: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK
Sbjct: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT 300
YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT
Sbjct: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDT 300
Query: 301 CMASFKGRKKANELQTETEGKHQ 323
CMASFKGRKKANELQTETEGKHQ
Sbjct: 301 CMASFKGRKKANELQTETEGKHQ 323
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 352 bits (903), Expect = 3e-97
Identities = 173/302 (57%), Positives = 223/302 (73%), Gaps = 7/302 (2%)
Query: 9 VLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDV 68
+ LGK + LE++++ ++PK +KNVAGEIVL TGAGSGLGR LA+ FAR G++LVLWD+
Sbjct: 13 IFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDI 72
Query: 69 NQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGK 128
N+EGN ETC++A+E G +V YTCDCS ++ VYRVADQV+KE GDV+IL+NNA +VTGK
Sbjct: 73 NKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGK 132
Query: 129 PFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYF 188
FLD PD ++EKSF VN H WT KAFLPA+I +HGHLVCISS AG+ G+NGL+D
Sbjct: 133 KFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD--- 189
Query: 189 VSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPIL 248
Y ASKFAAFGFAES+F E + K+ +K+TIVCP FI TGMFEGCT+ P LLPIL
Sbjct: 190 ----YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPIL 245
Query: 249 EQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308
E +Y +KI+ AIL+E++YL +PK Y + LK + K + +YLG+ M F +
Sbjct: 246 EPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQ 305
Query: 309 KK 310
KK
Sbjct: 306 KK 307
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 238 bits (607), Expect = 5e-63
Identities = 128/337 (37%), Positives = 195/337 (57%), Gaps = 35/337 (10%)
Query: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
M+++ + V+ K + F+ + ++ K+K+VAG++ L TGAGSGLGR A+ FAR
Sbjct: 1 MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRR 60
Query: 61 AILVLWDVNQEGNMETCRLAKE-------------KGGK-----------KVFPYTCDCS 96
A+LVLWD+N + N ET + + + G +VF YTCD
Sbjct: 61 ALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVG 120
Query: 97 NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAF 156
R+ VY A++VRKE G+V++LVNNA +V+G L+ PD ++E++ +VN HFWT KAF
Sbjct: 121 KRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAF 180
Query: 157 LPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKK 216
LP +++ NHGH+V ++S G+ G+ D Y ASKF GF ESL EL +K
Sbjct: 181 LPTMLEINHGHIVTVASSLGLFSTAGVED-------YCASKFGVVGFHESLSHELKAAEK 233
Query: 217 TEVKSTIVCPHFINTGMFEGCTSK---YPFLLPILEQEYVAKKILNAILEEQVYLMIPKF 273
+K+T+VCP+ ++TGMF GC + PF LP L+ +Y K+ + AIL +Q + P+
Sbjct: 234 DGIKTTLVCPYLVDTGMFRGCRIRKEIEPF-LPPLKPDYCVKQAMKAILTDQPMICTPRL 292
Query: 274 AYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGRKK 310
YI +K I+ + ++ +LG D CM F ++K
Sbjct: 293 MYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRK 329
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 216 bits (550), Expect = 2e-56
Identities = 120/284 (42%), Positives = 176/284 (61%), Gaps = 11/284 (3%)
Query: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
M++I + +LL Y +LESLV IP+++K+VAGEIVL TGAG G+GRQ FA+
Sbjct: 1 MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
Query: 61 AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
+ILVLWD+N+ G ET + K G Y DCSNR+E+YR +QV+KE GDVTI+VN
Sbjct: 61 SILVLWDINKRGVEETAAECR-KLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVN 119
Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
NA V L D + K+F VN + HFW KA LP++++ NHGH+V ++S+ G GI
Sbjct: 120 NAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGI 179
Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
++ PY S SKFAA GF L EL + KT +K++ +CP F+NTG + +++
Sbjct: 180 P------YLIPYCS-SKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR 232
Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQII 284
L P+LE + V + +++ IL + + +P + I L L++ +
Sbjct: 233 ---LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFL 273
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 215 bits (548), Expect = 4e-56
Identities = 127/299 (42%), Positives = 176/299 (58%), Gaps = 13/299 (4%)
Query: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
M + D +LL LES V IPK++K+V GEIVL TGAG G+GR A FA+
Sbjct: 1 MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
Query: 61 AILVLWDVNQEGNMETCRLAKEKG-GKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILV 119
+ LVLWD+N+ G ET AK KG G KV + DCSNR+++Y A +V+ E GDV+ILV
Sbjct: 61 SKLVLWDINKHGLEETA--AKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILV 118
Query: 120 NNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVG 179
NNA +V D +EK+F VN + HFWT KAFLPA+ K NHGH+V ++S AG V
Sbjct: 119 NNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVS 178
Query: 180 INGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTS 239
+ L Y +SKFAA GF ++L EL ++ T VK+T +CP+F+NTG + ++
Sbjct: 179 VPFLL-------AYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST 231
Query: 240 KYPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGV 298
L P LE E V ++++ IL EQ + IP L++I+ + L + + V
Sbjct: 232 S---LGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISV 287
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 186 bits (473), Expect = 2e-47
Identities = 111/294 (37%), Positives = 169/294 (57%), Gaps = 11/294 (3%)
Query: 16 YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAI-LVLWDVNQEGNM 74
Y +++ V ++P K ++++ E VL TG G G+GRQLA FA GA +VLW ++
Sbjct: 18 YLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLK 77
Query: 75 ETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIP 134
ET ++ G + + + CD NR+EVY+ A VR++ GD+TILVNNA +V GK +D
Sbjct: 78 ETTEEIRQMGTECHY-FICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSD 136
Query: 135 DHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYS 194
D + KS +N + FWT KAFLP +++ +GH+VC++S+ + I G D Y
Sbjct: 137 DDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAID-------YC 189
Query: 195 ASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVA 254
SK +AF F ESL L ++ V +T V P +T MF+G ++P L P L+ E VA
Sbjct: 190 TSKASAFAFMESL--TLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVA 247
Query: 255 KKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308
++ + A+ Q L++P + +ILK I+ L ++ G TCM +FKGR
Sbjct: 248 RRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGR 301
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 174 bits (442), Expect = 7e-44
Identities = 105/284 (36%), Positives = 157/284 (55%), Gaps = 47/284 (16%)
Query: 1 MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60
M++I + +LL Y +LESLV IP+++K+VAGEIVL TGAG G+GRQ FA+
Sbjct: 1 MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60
Query: 61 AILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVN 120
+ILVLWD+N +V+KE GDVTI+VN
Sbjct: 61 SILVLWDIN-------------------------------------KVKKEVGDVTIVVN 83
Query: 121 NADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGI 180
NA V L D + K+F VN + HFW KA LP++++ NHGH+V ++S+ G GI
Sbjct: 84 NAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGI 143
Query: 181 NGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
++ PY S SKFAA GF L EL + KT +K++ +CP F+NTG + +++
Sbjct: 144 P------YLIPYCS-SKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR 196
Query: 241 YPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQII 284
L P+LE + V + +++ IL + + +P + I L L++ +
Sbjct: 197 ---LWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFL 237
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 79.3 bits (194), Expect = 4e-15
Identities = 76/244 (31%), Positives = 112/244 (45%), Gaps = 26/244 (10%)
Query: 1 MDVIADTSVL------LGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAI 54
MD I T++L LG F + L V + K + +V+ TGA SGLG++ A
Sbjct: 16 MDFITSTAILPLLFGCLGVFGLFRLLQWV-----RGKAYLRNAVVVITGATSGLGKECAK 70
Query: 55 YFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVF---PY--TCDCSNRQEVYRVADQVR 109
F GA LVL N E R KV PY T D ++ + A ++
Sbjct: 71 VFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEIL 130
Query: 110 KEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLV 169
+ FG V ILVNNA + +D + ++ N KA LP++IK GH+V
Sbjct: 131 QCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIV 190
Query: 170 CISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFI 229
ISSI G + I S Y+ASK A F + L E+ ++ E++ T++ P +I
Sbjct: 191 AISSIQGKMSIPFRS-------AYAASKHATQAFFDCLRAEM---EQYEIEVTVISPGYI 240
Query: 230 NTGM 233
+T +
Sbjct: 241 HTNL 244
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 78.2 bits (191), Expect = 9e-15
Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 26/232 (11%)
Query: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQE------GNMETCRLAKE---KGGK 86
G +VL TGAG+GLGR A+ FA GA++V+ D+ + G++ ++ +E +GGK
Sbjct: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68
Query: 87 KVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
V Y + +E +V FG + ++VNNA ++ + F I D + V+
Sbjct: 69 AVANY----DSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHL 124
Query: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
F +A + K +G ++ SS +G+ G G ++ YSA+K G A S
Sbjct: 125 RGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQAN-------YSAAKLGLLGLANS 177
Query: 207 LFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVAKKIL 258
L E +K+ + + P N G T L+ L+ EYVA +L
Sbjct: 178 LAIE---GRKSNIHCNTIAP---NAGSRMTQTVMPEDLVEALKPEYVAPLVL 223
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 69.7 bits (169), Expect = 3e-12
Identities = 56/205 (27%), Positives = 96/205 (46%), Gaps = 16/205 (7%)
Query: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
+V G++ L TGA G+GR A GA + L D N E ++ C+ A ++ +K
Sbjct: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
Query: 91 YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
CD +++Q++ +V FG + ILVNNA + K + EK+ +N ++
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
L + K N G I +++ + G+ ++ + P Y ASK GF S
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRSAALA 168
Query: 211 LTMIKKTEVKSTIVCPHFINTGMFE 235
++ + V+ +CP F+NT + E
Sbjct: 169 ANLM-NSGVRLNAICPGFVNTAILE 192
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 68.9 bits (167), Expect = 6e-12
Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 33/293 (11%)
Query: 16 YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNME 75
+ L +V +I K + G V+ TG SG+G+ +AI + GA + L N++ ++
Sbjct: 12 FVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQ 71
Query: 76 T---CRLAKEKGGKKVFPYTCDCS-NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFL 131
+ + V + D S + +V V Q +++ G V +LVN A + F
Sbjct: 72 AKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFE 131
Query: 132 DIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSP 191
D+ E+ +N + + +A + + + G +V +SS AG +G+ G +
Sbjct: 132 DLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFT------- 184
Query: 192 YYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQE 251
YSASKFA G AE+L E +K V T+ P +T P +E
Sbjct: 185 AYSASKFAIRGLAEALQME---VKPYNVYITVAYPPDTDT--------------PGFAEE 227
Query: 252 YVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMAS 304
K + ++ E + P+ + KQI+ + F LG D M S
Sbjct: 228 NRTKPLETRLISETTSVCKPE-----QVAKQIVKDAIQGNFNSSLGSDGYMLS 275
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 68.2 bits (165), Expect = 1e-11
Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 14/191 (7%)
Query: 43 GAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVY 102
G G+GR +A AR G L + N EG A + GG + ++CD + +V
Sbjct: 9 GGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAA---AGDLGGDHL-AFSCDVAKEHDVQ 64
Query: 103 RVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIK 162
+++ K G V LVN A + + + N + TCKA + +I+
Sbjct: 65 NTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQ 124
Query: 163 ANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKST 222
G +V + SI G+ G +G S YSASK GF+ +L E + + +++
Sbjct: 125 QQGGSIVNVGSIVGLKGNSGQS-------VYSASKGGLVGFSRALAKE---VARKKIRVN 174
Query: 223 IVCPHFINTGM 233
+V P F++T M
Sbjct: 175 VVAPGFVHTDM 185
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 67.0 bits (162), Expect = 2e-11
Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 13/259 (5%)
Query: 10 LLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVN 69
+LG F Y+ S + P+ + G+ V+ TGA G+GR++A + A+ GA +V+ +
Sbjct: 11 ILGLFMAYYYYSANEEFRPEM---LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS 67
Query: 70 QEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKP 129
+E + E G + + Q K G + +L+ N T
Sbjct: 68 KETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLN 127
Query: 130 FLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFV 189
H V KS VN +++ A LP ++K ++G +V +SS+AG V Y +
Sbjct: 128 LFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVA-------YPM 179
Query: 190 SPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILE 249
YSASKFA GF S+ E + + + V T+ I+T S + +
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYS-VSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPK 238
Query: 250 QEYVAKKIL-NAILEEQVY 267
+E + I A+ +E+VY
Sbjct: 239 EECALEIIKGGALRQEEVY 257
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 67.0 bits (162), Expect = 2e-11
Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 13/259 (5%)
Query: 10 LLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVN 69
+LG F Y+ S + P+ + G+ V+ TGA G+GR++A + A+ GA +V+ +
Sbjct: 11 ILGLFMAYYYYSANEEFRPEM---LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARS 67
Query: 70 QEGNMETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKP 129
+E + E G + + Q K G + +L+ N T
Sbjct: 68 KETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLN 127
Query: 130 FLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFV 189
H V KS VN +++ A LP ++K ++G +V +SS+AG V Y +
Sbjct: 128 LFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVA-------YPM 179
Query: 190 SPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILE 249
YSASKFA GF S+ E + + + V T+ I+T S + +
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYS-VSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPK 238
Query: 250 QEYVAKKIL-NAILEEQVY 267
+E + I A+ +E+VY
Sbjct: 239 EECALEIIKGGALRQEEVY 257
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 64.7 bits (156), Expect = 1e-10
Identities = 52/182 (28%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 35 AGEIVLTTGAGSGLGRQLAIYFA-----RFGAILVLWDVNQEGNMETCRLAKEKGGKKVF 89
A VL +G SG+G +LA+ A R+ + + D+ ++ +E A E G+ +
Sbjct: 4 APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAA--AGEALGQTLT 61
Query: 90 PYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITH 149
D + + V + ++ G+V +LVNNA + P + ++ F N
Sbjct: 62 VAQLDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGA 118
Query: 150 FWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
KA LP + + GH+V ISS+ G+ G+ + Y+ASKFA GF ESL
Sbjct: 119 VRLVKAVLPGMKRRRQGHIVVISSVMGLQGV-------IFNDVYAASKFALEGFFESLAI 171
Query: 210 EL 211
+L
Sbjct: 172 QL 173
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 64.3 bits (155), Expect = 1e-10
Identities = 64/205 (31%), Positives = 92/205 (44%), Gaps = 14/205 (6%)
Query: 31 KKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEG--NMETCRLAKEKGGKKV 88
K V ++V+ T A SGLG++ A F GA LVL N E N+ ++ K
Sbjct: 32 KSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTF 91
Query: 89 FP--YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
P D S+ V VA +V +G V IL+NNA + P I + +K N
Sbjct: 92 TPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANY 151
Query: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
KA LP +I G +V +++I G GI Y+ASK AA GF +
Sbjct: 152 FGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIP-------FRTTYAASKHAALGFFDC 204
Query: 207 LFFELTMIKKTEVKSTIVCPHFINT 231
L E +++ +V + V P FI +
Sbjct: 205 LRAE---VEEYDVVISTVSPTFIRS 226
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 62.0 bits (149), Expect = 7e-10
Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 6/145 (4%)
Query: 34 VAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQE------GNMETCRLAKEKGGKK 87
+AG V TGA G+G+ +A+ A+ GA +V+ + G + T E G K
Sbjct: 8 LAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGK 67
Query: 88 VFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAI 147
P D + Q++ ++ K+FG + ILVNNA ++ LD P ++ VN
Sbjct: 68 ALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTR 127
Query: 148 THFWTCKAFLPAVIKANHGHLVCIS 172
+ KA +P + K+ H++ IS
Sbjct: 128 GTYLASKACIPYLKKSKVAHILNIS 152
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 61.6 bits (148), Expect = 9e-10
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 12/201 (5%)
Query: 38 IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGG---KKVFPYTCD 94
+V TGA SG+G +LA ++ G LVL R E G K + D
Sbjct: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
Query: 95 CSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCK 154
++ V +EFG + ILVNN + +D + K +N + K
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
Query: 155 AFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMI 214
LP +I+ G +V ++SI G++ + +S Y ASK A GF L EL
Sbjct: 172 CVLPHMIERKQGKIVTVNSILGIISVP-------LSIGYCASKHALRGFFNGLRTELATY 224
Query: 215 KKTEVKSTIVCPHFINTGMFE 235
V + +CP + + + E
Sbjct: 225 PGIIVSN--ICPGPVQSNIVE 243
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/196 (24%), Positives = 95/196 (48%), Gaps = 19/196 (9%)
Query: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
G++++ T A G+G+ A+ FAR GA ++ D+N+ E L K G + D
Sbjct: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE---LEKYPG---IQTRVLDV 59
Query: 96 SNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKA 155
+ ++++ + A++V + + +L N A V LD + + S +N + + KA
Sbjct: 60 TKKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKA 115
Query: 156 FLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIK 215
FLP ++ G+++ +SS+A + G+ + YS +K A G +S+ +
Sbjct: 116 FLPKMLAQKSGNIINMSSVAS--SVKGVVNRC----VYSTTKAAVIGLTKSVAADFI--- 166
Query: 216 KTEVKSTIVCPHFINT 231
+ ++ VCP ++T
Sbjct: 167 QQGIRCNCVCPGTVDT 182
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 60.5 bits (145), Expect = 2e-09
Identities = 53/202 (26%), Positives = 93/202 (46%), Gaps = 19/202 (9%)
Query: 38 IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMET----CRLAKEKGGKKVFPYTC 93
+ L TGA G+G +A + G + V+ GN+E C+ A G + PY C
Sbjct: 13 LALVTGASGGIGAAVARALVQQG-LKVVGCARTVGNIEELAAECKSAGYPG--TLIPYRC 69
Query: 94 DCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTC 153
D SN +++ + +R + V I +NNA L L + F VN +
Sbjct: 70 DLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICT 129
Query: 154 KAFLPAVIKAN--HGHLVCISSIAG--VVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
+ ++ + N GH++ I+S++G V+ ++ V+ +YSA+K+A E L
Sbjct: 130 REAYQSMKERNVDDGHIININSMSGHRVLPLS-------VTHFYSATKYAVTALTEGLRQ 182
Query: 210 ELTMIKKTEVKSTIVCPHFINT 231
EL +T +++T + P + T
Sbjct: 183 ELRE-AQTHIRATCISPGVVET 203
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 59.3 bits (142), Expect = 4e-09
Identities = 57/211 (27%), Positives = 95/211 (45%), Gaps = 18/211 (8%)
Query: 38 IVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFP------Y 91
+ L TGAGSG+GR +++ A GA + D+++ ET RL G K+ P +
Sbjct: 13 LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
Query: 92 TCDCSNRQEVYRVADQVRKEFG-DVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
D S + + +QV+ F +++V+ A + + L + + +K VN F
Sbjct: 73 QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132
Query: 151 WTCKAFLPAVIKAN-HGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
+A A++ G ++ ISSI G VG G ++ Y+ASK G ++
Sbjct: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN-------YAASKAGVIGLTQTAAR 185
Query: 210 ELTMIKKTEVKSTIVCPHFINTGMFEGCTSK 240
EL + ++ V P FI T M + K
Sbjct: 186 EL---GRHGIRCNSVLPGFIATPMTQKVPQK 213
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 57.8 bits (138), Expect = 1e-08
Identities = 49/176 (27%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
+V G++ L TGA G+GR A GA + L D N E ++ C+ A ++ +K
Sbjct: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
Query: 91 YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
CD +++Q++ +V FG + ILVNNA + K + EK+ +N ++
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
L + K N G I +++ + G+ ++ + P Y ASK GF S
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRS 164
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 21/224 (9%)
Query: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
G++ + TGA G+GR +A+ + GA + + + + + A+ GG+ V P CD
Sbjct: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65
Query: 96 SNRQEVYRVADQV-RKEFGDVTILVNNADL-------VTGKPFLDIPDHMVEKSFLVNAI 147
S EV + +QV R++ G + +LVNNA K F + P M + V
Sbjct: 66 SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
Query: 148 THFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
H++ ++ A G +V ISS + +Y + Y K A A
Sbjct: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL--------QYMFNVPYGVGKAACDKLAADC 177
Query: 208 FFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLL-PILEQ 250
EL ++ V + P + T + + +K L P+L+Q
Sbjct: 178 AHEL---RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ 218
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 54.3 bits (129), Expect = 1e-07
Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 21/224 (9%)
Query: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
G++ + TGA G+GR +A+ + GA + + + + + A+ GG+ V P CD
Sbjct: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCV-PVVCDS 65
Query: 96 SNRQEVYRVADQV-RKEFGDVTILVNNADL-------VTGKPFLDIPDHMVEKSFLVNAI 147
S EV + +QV R++ G + +LVNNA K F + P M + V
Sbjct: 66 SQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLR 125
Query: 148 THFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
H++ ++ A G +V ISS + +Y + Y K A A
Sbjct: 126 GHYFCSVYGARLMVPAGQGLIVVISSPGSL--------QYMFNVPYGVGKAACDKLAADC 177
Query: 208 FFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLL-PILEQ 250
EL ++ V + P + T + + +K L P+L+Q
Sbjct: 178 AHEL---RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQ 218
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 53.1 bits (126), Expect = 3e-07
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 17/188 (9%)
Query: 31 KKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCR-LAKEKGGKKVF 89
K + G+ V+ TGA +G+G+Q A+ AR G ++L +ME C AK+ G+ +
Sbjct: 33 KATIPGKTVIVTGANTGIGKQTALELARRGGNIIL----ACRDMEKCEAAAKDIRGETLN 88
Query: 90 PYT----CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVN 145
+ D ++ + + A ++ +E V IL+NNA V P D E F VN
Sbjct: 89 HHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAG-VMRCPHWTTEDGF-EMQFGVN 146
Query: 146 AITHFWTCKAFLPAVIKANHGHLVCISSIAGVVG------INGLSDEYFVSPYYSASKFA 199
+ HF L + + ++ +SS+A V G +N + +Y Y SK A
Sbjct: 147 HLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLA 206
Query: 200 AFGFAESL 207
F + L
Sbjct: 207 IVLFTKEL 214
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/181 (29%), Positives = 84/181 (46%), Gaps = 12/181 (6%)
Query: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYT 92
++ G VL TGA +G+G +LA ++AR G+ LVL + + ++ G KVF
Sbjct: 26 SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85
Query: 93 CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL--VNAITHF 150
D ++ + V + G + LV N + G P +L VN +++
Sbjct: 86 ADMASPEAPESVVQFALDKLGGLDYLVLNH--IGGAPAGTRARSPQATRWLMQVNFVSYV 143
Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
LP++ + G LV +SS+ G V + F +P YSA+KFA GF SL E
Sbjct: 144 QLTSRALPSLTDSK-GSLVVVSSLLGRVPTS------FSTP-YSAAKFALDGFFGSLRRE 195
Query: 211 L 211
L
Sbjct: 196 L 196
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/181 (29%), Positives = 84/181 (46%), Gaps = 12/181 (6%)
Query: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYT 92
++ G VL TGA +G+G +LA ++AR G+ LVL + + ++ G KVF
Sbjct: 26 SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85
Query: 93 CDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL--VNAITHF 150
D ++ + V + G + LV N + G P +L VN +++
Sbjct: 86 ADMASPEAPESVVQFALDKLGGLDYLVLNH--IGGAPAGTRARSPQATRWLMQVNFVSYV 143
Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
LP++ + G LV +SS+ G V + F +P YSA+KFA GF SL E
Sbjct: 144 QLTSRALPSLTDSK-GSLVVVSSLLGRVPTS------FSTP-YSAAKFALDGFFGSLRRE 195
Query: 211 L 211
L
Sbjct: 196 L 196
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/179 (26%), Positives = 75/179 (41%), Gaps = 14/179 (7%)
Query: 34 VAGEIVLTTGAGSGLGRQLAIYFAR-----FGAILVLWDVNQEGNMETCRLAKEKGGKKV 88
+A +VL TG SG+G LA+ A F L D+ +G + A +
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
Query: 89 FPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAIT 148
D + + V ++V + G V +LV NA L P + + V VN +
Sbjct: 61 ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
Query: 149 HFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESL 207
+AFLP + + G ++ S+ G++G+ + Y ASKFA G ESL
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLP-------FNDVYCASKFALEGLCESL 170
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 50.4 bits (119), Expect = 2e-06
Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 13/149 (8%)
Query: 35 AGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCD 94
AG++V+ TG G G+G + F GA +V+ D ++ G R +++ VF CD
Sbjct: 8 AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPGAVF-ILCD 62
Query: 95 CSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFL----VNAITHF 150
+ +V + + + FG + +VNNA P P+ + F +N + +
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAG---HHPPPQRPEETSAQGFRQLLELNLLGTY 119
Query: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVG 179
K LP ++ + G+++ ISS+ G +G
Sbjct: 120 TLTKLALP-YLRKSQGNVINISSLVGAIG 147
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 48.5 bits (114), Expect = 8e-06
Identities = 52/202 (25%), Positives = 100/202 (49%), Gaps = 20/202 (9%)
Query: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
GE + TG+ G+G+ A A+ G +VL +++ + KEK + D
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
Query: 96 SNRQEVYRVADQVRKEFG--DVTILVNNADLVTGKP--FLDIP--DHMVEKSFLVNAITH 149
++ +++Y D+++ ++ ILVNN + P FLD+P D++++K +N ++
Sbjct: 110 AS-EDIY---DKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165
Query: 150 FWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFF 209
+ LP +++ + G ++ ISS +G++ + L+ YSA+K F++ L
Sbjct: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLT-------IYSATKTFVDFFSQCLHE 218
Query: 210 ELTMIKKTEVKSTIVCPHFINT 231
E K V+S V P+F+ T
Sbjct: 219 EYRS-KGVFVQS--VLPYFVAT 237
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,007,736
Number of Sequences: 37866
Number of extensions: 445796
Number of successful extensions: 954
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 870
Number of HSP's gapped (non-prelim): 69
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.