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Search of human proteins with 223278413
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223278413 MAM domain containing 2 [Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223278413 MAM domain containing 2 [Homo sapiens] 1422 0.0
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 142 1e-33
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 141 2e-33
gi|119220585 apical early endosomal glycoprotein precursor [Homo... 126 6e-29
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 120 5e-27
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 105 1e-22
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 105 1e-22
gi|16554449 zonadhesin isoform 3 [Homo sapiens] 96 1e-19
gi|27881494 zonadhesin isoform 6 [Homo sapiens] 96 1e-19
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 93 9e-19
gi|223942069 enterokinase precursor [Homo sapiens] 84 6e-16
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 74 4e-13
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 61 3e-09
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 61 3e-09
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 61 4e-09
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 61 4e-09
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 61 4e-09
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 59 1e-08
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 59 1e-08
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 59 2e-08
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 59 2e-08
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 59 2e-08
gi|153070264 meprin A beta [Homo sapiens] 57 4e-08
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 55 2e-07
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 55 2e-07
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 55 2e-07
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 55 2e-07
gi|13124888 epidermal growth factor-like protein 6 precursor [Ho... 55 3e-07
gi|239755252 PREDICTED: hypothetical protein [Homo sapiens] 53 1e-06
gi|169201936 PREDICTED: hypothetical protein [Homo sapiens] 53 1e-06
>gi|223278413 MAM domain containing 2 [Homo sapiens]
Length = 686
Score = 1422 bits (3681), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 60
MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG
Sbjct: 1 MLLRGVLLALQALQLAGALDLPAGSCAFEESTCGFDSVLASLPWILNEEGHYIYVDTSFG 60
Query: 61 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE
Sbjct: 61 KQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
Query: 121 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 180
PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF
Sbjct: 121 PSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIECDFEENHLCGF 180
Query: 181 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 240
VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT
Sbjct: 181 VNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTT 240
Query: 241 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 300
APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME
Sbjct: 241 APMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME 300
Query: 301 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 360
VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW
Sbjct: 301 VIFEVAFNGPKGGYVALDDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGW 360
Query: 361 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 420
TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG
Sbjct: 361 TRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYG 420
Query: 421 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 480
FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD
Sbjct: 421 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWD 480
Query: 481 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 540
CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT
Sbjct: 481 CGLVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYT 540
Query: 541 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY 600
GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY
Sbjct: 541 GPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVY 600
Query: 601 LKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQ 660
LKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQ
Sbjct: 601 LKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQ 660
Query: 661 AGPCGEMEDTTQQSSGYSEDLNEIEY 686
AGPCGEMEDTTQQSSGYSEDLNEIEY
Sbjct: 661 AGPCGEMEDTTQQSSGYSEDLNEIEY 686
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 142 bits (357), Expect = 1e-33
Identities = 174/678 (25%), Positives = 269/678 (39%), Gaps = 136/678 (20%)
Query: 98 SQLNLYMRFEDESFDRLLWSAKEPSDS-WLIASLDLQNSSKKFKILIEGVL--------- 147
S + L+ E+E F W+ + S W+ A + + K FKI+ EG L
Sbjct: 2 SDVFLFKSKEEEIF----WTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFIAL 57
Query: 148 ------GQGNTASIALF---EIKMTTGYCIE---------------------------CD 171
G T S L E T+G CI CD
Sbjct: 58 DHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCD 117
Query: 172 FEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEV 231
FE CG+ + +W + G H DHT G ++Y+++ + V
Sbjct: 118 FESG-FCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGV 173
Query: 232 AQLISP----LTTAPMAGCLSFYYQIQQGNDNVFSLYTR-DVAGLYEEIWKADRPGNAAW 286
A+L SP L TA + F+Y + Q ++ S++TR + G ++ K R + W
Sbjct: 174 AKLGSPVLTKLLTASTPCQVQFWYHLSQHSN--LSVFTRTSLDGNLQKQGKIIRFSESQW 231
Query: 287 NLAEVEFSAP-----YPMEVIFEVAFNGPKGGYVALDDISFSPVHCQ--------NQTEL 333
+ A+++ A P ++I E VALDDIS S C+ T+
Sbjct: 232 SHAKIDLIAEAGESTLPFQLILEATVLS-SNATVALDDISVSQ-ECEISYKSLPRTSTQS 289
Query: 334 LFSAVEASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAG--------DHTTGL--GYYL 383
FS C+FE + C++++ G + ++ + A DH+ G+++
Sbjct: 290 KFS----KCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFM 345
Query: 384 LANTKFTSQPGYIGRLYGPSLPGNLQYC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEK 442
K +S + +L P+ C L F + YG + L +++ EN
Sbjct: 346 FILKK-SSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHM--ENSHDSTV 402
Query: 443 IWSVLESPRGVWMQAEITFKK-PMPTKVVFMSLCKSFWDCGLVALDDITIQ-------LG 494
IW VL + W++A I + P + + +D G+ A+DDI +
Sbjct: 403 IWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYD-GVSAIDDIRFENCTLPLPAE 461
Query: 495 SCSSS------------EKLP-----------------PPPGECTFEQDECTFTQEKRNR 525
SC EKL P +C FE C + Q+ ++
Sbjct: 462 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDD 521
Query: 526 SSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEASH-MVYGQKARLLSRPLRGVSGKHC 582
W R +G TPT TGP D+T G G+Y+YIE+S + A LLS L K C
Sbjct: 522 FDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGC 581
Query: 583 -LTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFE 641
F+YHM+G L++Y + DS LLW+ G Q W+R + S + QI+ E
Sbjct: 582 TFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVE 641
Query: 642 AIRGVSIRSDIAIDDVKF 659
A G DIAIDD+ F
Sbjct: 642 ASVGDGFTGDIAIDDLSF 659
Score = 124 bits (310), Expect = 4e-28
Identities = 173/785 (22%), Positives = 294/785 (37%), Gaps = 156/785 (19%)
Query: 25 SCAFEESTCGFDSVLAS------LPWILNEEGHYIYVDTSFGKQGEKAVLL----SPDLQ 74
+C FE CG++ L + + N E H+ D + + L SP +
Sbjct: 115 TCDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVA 174
Query: 75 AEEWSCLRLVYQITTSSE-----SLSDPSQLNLYMRFE-DESFDRLLWSAKEPSDSWLIA 128
L + +T + LS S L+++ R D + + + W A
Sbjct: 175 KLGSPVLTKLLTASTPCQVQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHA 234
Query: 129 SLDL----QNSSKKFKILIEGVLGQGNTASIALFEIKM---------------TTGYCIE 169
+DL S+ F++++E + N A++AL +I + T +
Sbjct: 235 KIDLIAEAGESTLPFQLILEATVLSSN-ATVALDDISVSQECEISYKSLPRTSTQSKFSK 293
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNV---HSILPQDHTFKSELGHYMYVDSVYVK 226
CDFE N F + +W S + H P+DH+ + GH+M++
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 227 HFQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEE--IWKADRPGNA 284
+Q VA+L SP + GC+ ++ G + + ++ IW+
Sbjct: 354 LWQ-VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGK 412
Query: 285 AWNLAEVEFSA-PYPMEVIFEVAFNGPKGGYVALDDISFSPV------------------ 325
W A ++ P + + G G A+DDI F
Sbjct: 413 QWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCR 472
Query: 326 ----------------HCQNQTELLFSAVEASCNFEQDLCNFYQD-KEGPGWTRVKVKPN 368
C ++T+ + A E CNFE +CN+ QD K+ WTR +
Sbjct: 473 HTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPTP 532
Query: 369 MYRAG---DHTTGL--GYYLLANTKFTSQPGYIGRLYGPSLPG-NLQYC-LRFHYAIYGF 421
G D+T G G+YL + L P L + + C RF+Y ++G
Sbjct: 533 TLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG- 591
Query: 422 LKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLC------ 475
K LA+Y + + +W + + W++ + P +++ +
Sbjct: 592 -KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTG 650
Query: 476 ------KSFWDCGLVALD-------------DITIQLGSCSSSEKLPPPPGECTFEQDEC 516
SF DC L + +T+ +C+ +E + G C + +C
Sbjct: 651 DIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKC 710
Query: 517 TF------------------TQEKRNRSSWHR---------------RRGETPTSYTG-- 541
F + EKR+ W++ G + + G
Sbjct: 711 DFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEE 770
Query: 542 ---PKGDHT--TGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LTFFYHMYGGGTG 595
P DHT T G+Y+Y ++S+ +G A +L+ P+ ++G C L F+ HM G G
Sbjct: 771 NHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILT-PIISLTGPKCTLVFWTHMNGATVG 829
Query: 596 LLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAID 655
L V +KK D+ S LW + G+Q W RA + QI+F A RG+S D+A+D
Sbjct: 830 SLQVLIKK--DNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVD 887
Query: 656 DVKFQ 660
D+ FQ
Sbjct: 888 DISFQ 892
Score = 120 bits (301), Expect = 4e-27
Identities = 143/629 (22%), Positives = 238/629 (37%), Gaps = 142/629 (22%)
Query: 168 IECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKH 227
++C+FE +C + + +W G +++ +D+T + GHY+Y++S +
Sbjct: 503 LQCNFETG-ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQA 561
Query: 228 FQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWN 287
FQ+ A L+SP+ A +F + ++ L +Y+ IW +D G W
Sbjct: 562 FQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRL------AIYQRIW-SDSRGQLLWQ 614
Query: 288 L----------AEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFS-------------- 323
+ + S+ P +++ E + G +A+DD+SF
Sbjct: 615 IFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP 674
Query: 324 -----------PVHCQNQTELLF--------------------------SAVEASCNFEQ 346
P H E + S V C+FE+
Sbjct: 675 TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEK 734
Query: 347 -DLCNFYQDKE--------------GPGWTRVKVKPNMYRAGDHT--TGLGYYLLA---N 386
LC +YQ G G + + N + DHT T G+YL A N
Sbjct: 735 RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSN 794
Query: 387 TKFTSQPGYIGRLYGPSLPG-NLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWS 445
KF + + + P L + + A G +L V I ++N V K+W+
Sbjct: 795 GKFGDTADILTPIISLTGPKCTLVFWTHMNGATVG------SLQVLIKKDN--VTSKLWA 846
Query: 446 VLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGS---------- 495
W +AE+ T++VF + + G VA+DDI+ Q S
Sbjct: 847 QTGQQGAQWKRAEVFLGIRSHTQIVFRAK-RGISYIGDVAVDDISFQDCSPLLSPERKCT 905
Query: 496 ----------CSSSEKL------------------PPPPGECTFEQDECTFTQEKRNRSS 527
C + +KL G C FE D C++ QEK
Sbjct: 906 DHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFD 965
Query: 528 WHRRRGETPTSYTGPKGDHTTG--VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LT 584
W+ + P + T P DHT G G+Y++I++ +A +S P+ K+C +
Sbjct: 966 WNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKII 1025
Query: 585 FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIR 644
F YHMYG G G L++ ++ ++ +L EQ W R + + Q+ FE
Sbjct: 1026 FHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRV 1084
Query: 645 GVSIRSDIAIDDVKFQAGPCGEMEDTTQQ 673
G R DIA+DD+ C + D+ Q+
Sbjct: 1085 GKGQRGDIALDDIVLTEN-CLSLHDSVQE 1112
Score = 83.6 bits (205), Expect = 6e-16
Identities = 132/595 (22%), Positives = 222/595 (37%), Gaps = 139/595 (23%)
Query: 49 EGHYIYVDTSFGKQ-GEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFE 107
+GHY+Y+++S + + A LLSP L A + + + + +L +Y R
Sbjct: 548 KGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIY---RLAIYQRIW 604
Query: 108 DESFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM---- 162
+S +LLW + W+ L++ +S + F+IL+E +G G T IA+ ++
Sbjct: 605 SDSRGQLLWQIFGNQGNRWIRKHLNI-SSRQPFQILVEASVGDGFTGDIAIDDLSFMDCT 663
Query: 163 -----------------------------------TTGYCIE----CDFEEN-------- 175
+ G+CIE CDF+ +
Sbjct: 664 LYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA 723
Query: 176 ----HLCGFVNR----WNPNV-----------NWFVGGG-SIRN-VHSILPQ-DHTFKSE 213
+C F R W + W +G G SI + + P DHT +
Sbjct: 724 SCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTT 783
Query: 214 LGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQQGND--NVFSLYTRDVAGL 271
G Y+Y DS K F + A +++P+ + C ++ G ++ L +D +
Sbjct: 784 DGWYLYADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKD--NV 840
Query: 272 YEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISF---SPV--- 325
++W A W AEV +++F G VA+DDISF SP+
Sbjct: 841 TSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSP 900
Query: 326 --------------HC----------------QNQTELLFSAVEASCNFEQDLCNFYQDK 355
HC ++T + C+FE DLC++ Q+K
Sbjct: 901 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEK 960
Query: 356 EGPGWTRVKVK----PNMYRAGDHTTG--LGYYLLANTKFTSQPGYIGRLYGPSLPGNLQ 409
+ +K A DHT G G+Y+ + F QP R+ P + +
Sbjct: 961 DEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSK 1020
Query: 410 YC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRG-VWMQAEITFKKPMPT 467
C + FHY +YG + A+ + + + Q K+ L +G W + E++
Sbjct: 1021 NCKIIFHYHMYG----NGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDF 1076
Query: 468 KVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEK------LPPPPGECTFEQDEC 516
++ F G +ALDDI + S + +P P G C EC
Sbjct: 1077 QLKFEGRVGK-GQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYREC 1130
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 163 TTGYCIECDFEENH-----LCGFVNRWNPNVNWFVGGGSIRNVHSILPQ-DHTFKSELGH 216
TTG C+FE + C +++W +G S +++P DHT S H
Sbjct: 1435 TTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIG--SRIPAKALIPDSDHTPGSGQ-H 1488
Query: 217 YMYVDSVYVKHFQEVAQLISPLTTAPMAGCLS--FYYQIQQGNDNVFSLYTRDVAGLYEE 274
++YV+S K S A + C ++Y I + + +YT + +GL
Sbjct: 1489 FLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNIL 1548
Query: 275 IWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSP 324
+W W V S+ P +V FE +G + ++ALDDISF+P
Sbjct: 1549 VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP 1598
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 507 GECTFEQDE------CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVG-YYMYIEAS 559
G C FE C+ TQ+ + W P P DHT G G +++Y+ +S
Sbjct: 1437 GSCNFETSSGNWTTACSLTQDSEDDLDW-AIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1495
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLT--FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
G AR+ + S C +FY + G+L VY EE L+W G
Sbjct: 1496 GSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTI-EESGLNILVWSVIG 1554
Query: 618 EQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKF 659
+ W + S ++ FEA + IA+DD+ F
Sbjct: 1555 NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1596
Score = 38.9 bits (89), Expect = 0.016
Identities = 48/230 (20%), Positives = 88/230 (38%), Gaps = 79/230 (34%)
Query: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQ----------ITTSSESLSD 96
N GHYI++ + F +Q +A +S + ++ ++++ +T S+++
Sbjct: 988 NSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTN 1047
Query: 97 PSQLNLYMRFEDESFDRLLWSAKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIA 156
+++ L + E +F W +E S L D F++ EG +G+G IA
Sbjct: 1048 QTKVLLNLTVEQGNF----WRREELS---LFGDED-------FQLKFEGRVGKGQRGDIA 1093
Query: 157 LFEIKMT-------------------TGYC----------------IECDFEEN------ 175
L +I +T TG+C C+F +N
Sbjct: 1094 LDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTG 1153
Query: 176 ------------HLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSE 213
CG+ N N +W +G GS +++ P+DHT +E
Sbjct: 1154 ENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRP--PKDHTLGNE 1201
Score = 37.7 bits (86), Expect = 0.036
Identities = 62/278 (22%), Positives = 105/278 (37%), Gaps = 53/278 (19%)
Query: 424 MSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPT-KVVFMSLCKS----- 477
MSD V++F+ +E W+ S W++A++ + + T K++F S
Sbjct: 1 MSD---VFLFKSKE--EEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFI 55
Query: 478 ------FWDCG------LVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKR-- 523
+ CG L + D+ G C + E + +C+ E DE T K
Sbjct: 56 ALDHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT 115
Query: 524 ---------------NRSSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEA--SHMVYG 564
S W +G + P DHT + G ++Y+EA S V
Sbjct: 116 CDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVAK 175
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWL 624
+ +L++ L S + F+YH+ LSV+ + D + W
Sbjct: 176 LGSPVLTK-LLTASTPCQVQFWYHLSQHSN--LSVFTRTSLDGNLQKQGKIIRFSESQWS 232
Query: 625 RALIEYSCER-----QHQIIFEAIRGVSIRSDIAIDDV 657
A I+ E Q+I EA +S + +A+DD+
Sbjct: 233 HAKIDLIAEAGESTLPFQLILEA-TVLSSNATVALDDI 269
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 51 HYIYVDTSFGKQGEKA-VLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
H++YV++S K+G A + S A C + S+ L +Y E+
Sbjct: 1488 HFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSM---GILKVY-TIEES 1543
Query: 110 SFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMT 163
+ L+WS W S+ L +S+ FK+ E L IAL +I T
Sbjct: 1544 GLNILVWSVIGNKRTGWTYGSVPL-SSNSPFKVAFEADLDGNEDIFIALDDISFT 1597
Score = 29.6 bits (65), Expect = 9.7
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 536 PTSYTGPKGDHTTGVGYYMYIEASHM-VYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGT 594
P T DH ++MY+EA+ + + G KA S R S ++F+Y + T
Sbjct: 1250 PNENTFGSSDHMNW--HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKAT 1307
Query: 595 GLLSVYLKK 603
G + + +K+
Sbjct: 1308 GSIQILIKR 1316
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 141 bits (356), Expect = 2e-33
Identities = 174/678 (25%), Positives = 269/678 (39%), Gaps = 136/678 (20%)
Query: 98 SQLNLYMRFEDESFDRLLWSAKEPSDS-WLIASLDLQNSSKKFKILIEGVL--------- 147
S + L+ E+E F W+ + S W+ A + + K FKI+ EG L
Sbjct: 2 SDVFLFKSKEEEIF----WTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFIAL 57
Query: 148 ------GQGNTASIALF---EIKMTTGYCIE---------------------------CD 171
G T S L E T+G CI CD
Sbjct: 58 DHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCD 117
Query: 172 FEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEV 231
FE CG+ + +W + G H DHT G ++Y+++ + V
Sbjct: 118 FESG-FCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGV 173
Query: 232 AQLISP----LTTAPMAGCLSFYYQIQQGNDNVFSLYTR-DVAGLYEEIWKADRPGNAAW 286
A+L SP L TA + F+Y + Q ++ S++TR + G ++ K R + W
Sbjct: 174 AKLGSPVLTKLLTASTPCQVQFWYHLSQHSN--LSVFTRTSLDGNLQKQGKIIRFSESQW 231
Query: 287 NLAEVEFSAP-----YPMEVIFEVAFNGPKGGYVALDDISFSPVHCQ--------NQTEL 333
+ A+++ A P ++I E VALDDIS S C+ T+
Sbjct: 232 SHAKIDLIAEAGESTLPFQLILEATVLS-SNATVALDDISVSQ-ECEISYKSLPRTSTQS 289
Query: 334 LFSAVEASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAG--------DHTTGL--GYYL 383
FS C+FE + C++++ G + ++ + A DH+ G+++
Sbjct: 290 KFS----KCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFM 345
Query: 384 LANTKFTSQPGYIGRLYGPSLPGNLQYC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEK 442
K +S + +L P+ C L F + YG + L +++ EN
Sbjct: 346 FILKK-SSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHM--ENSHDSTV 402
Query: 443 IWSVLESPRGVWMQAEITFKK-PMPTKVVFMSLCKSFWDCGLVALDDITIQ-------LG 494
IW VL + W++A I + P + + +D G+ A+DDI +
Sbjct: 403 IWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYD-GVSAIDDIRFENCTLPLPAE 461
Query: 495 SCSSS------------EKLP-----------------PPPGECTFEQDECTFTQEKRNR 525
SC EKL P +C FE C + Q+ ++
Sbjct: 462 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDD 521
Query: 526 SSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEASH-MVYGQKARLLSRPLRGVSGKHC 582
W R +G TPT TGP D+T G G+Y+YIE+S + A LLS L K C
Sbjct: 522 FDWTRSQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGC 581
Query: 583 -LTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFE 641
F+YHM+G L++Y + DS LLW+ G Q W+R + S + QI+ E
Sbjct: 582 TFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVE 641
Query: 642 AIRGVSIRSDIAIDDVKF 659
A G DIAIDD+ F
Sbjct: 642 ASVGDGFTGDIAIDDLSF 659
Score = 124 bits (311), Expect = 3e-28
Identities = 173/785 (22%), Positives = 294/785 (37%), Gaps = 156/785 (19%)
Query: 25 SCAFEESTCGFDSVLAS------LPWILNEEGHYIYVDTSFGKQGEKAVLL----SPDLQ 74
+C FE CG++ L + + N E H+ D + + L SP +
Sbjct: 115 TCDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVA 174
Query: 75 AEEWSCLRLVYQITTSSE-----SLSDPSQLNLYMRFE-DESFDRLLWSAKEPSDSWLIA 128
L + +T + LS S L+++ R D + + + W A
Sbjct: 175 KLGSPVLTKLLTASTPCQVQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHA 234
Query: 129 SLDL----QNSSKKFKILIEGVLGQGNTASIALFEIKM---------------TTGYCIE 169
+DL S+ F++++E + N A++AL +I + T +
Sbjct: 235 KIDLIAEAGESTLPFQLILEATVLSSN-ATVALDDISVSQECEISYKSLPRTSTQSKFSK 293
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNV---HSILPQDHTFKSELGHYMYVDSVYVK 226
CDFE N F + +W S + H P+DH+ + GH+M++
Sbjct: 294 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 353
Query: 227 HFQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEE--IWKADRPGNA 284
+Q VA+L SP + GC+ ++ G + + ++ IW+
Sbjct: 354 LWQ-VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGK 412
Query: 285 AWNLAEVEFSA-PYPMEVIFEVAFNGPKGGYVALDDISFSPV------------------ 325
W A ++ P + + G G A+DDI F
Sbjct: 413 QWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCR 472
Query: 326 ----------------HCQNQTELLFSAVEASCNFEQDLCNFYQD-KEGPGWTRVKVKPN 368
C ++T+ + A E CNFE +CN+ QD K+ WTR +
Sbjct: 473 HTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTP 532
Query: 369 MYRAG---DHTTGL--GYYLLANTKFTSQPGYIGRLYGPSLPG-NLQYC-LRFHYAIYGF 421
G D+T G G+YL + L P L + + C RF+Y ++G
Sbjct: 533 TLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG- 591
Query: 422 LKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLC------ 475
K LA+Y + + +W + + W++ + P +++ +
Sbjct: 592 -KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTG 650
Query: 476 ------KSFWDCGLVALD-------------DITIQLGSCSSSEKLPPPPGECTFEQDEC 516
SF DC L + +T+ +C+ +E + G C + +C
Sbjct: 651 DIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKC 710
Query: 517 TF------------------TQEKRNRSSWHR---------------RRGETPTSYTG-- 541
F + EKR+ W++ G + + G
Sbjct: 711 DFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEE 770
Query: 542 ---PKGDHT--TGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LTFFYHMYGGGTG 595
P DHT T G+Y+Y ++S+ +G A +L+ P+ ++G C L F+ HM G G
Sbjct: 771 NHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILT-PIISLTGPKCTLVFWTHMNGATVG 829
Query: 596 LLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAID 655
L V +KK D+ S LW + G+Q W RA + QI+F A RG+S D+A+D
Sbjct: 830 SLQVLIKK--DNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVD 887
Query: 656 DVKFQ 660
D+ FQ
Sbjct: 888 DISFQ 892
Score = 120 bits (301), Expect = 4e-27
Identities = 143/629 (22%), Positives = 238/629 (37%), Gaps = 142/629 (22%)
Query: 168 IECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKH 227
++C+FE +C + + +W G +++ +D+T + GHY+Y++S +
Sbjct: 503 LQCNFETG-ICNWEQDAKDDFDWTRSQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQA 561
Query: 228 FQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWN 287
FQ+ A L+SP+ A +F + ++ L +Y+ IW +D G W
Sbjct: 562 FQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRL------AIYQRIW-SDSRGQLLWQ 614
Query: 288 L----------AEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFS-------------- 323
+ + S+ P +++ E + G +A+DD+SF
Sbjct: 615 IFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP 674
Query: 324 -----------PVHCQNQTELLF--------------------------SAVEASCNFEQ 346
P H E + S V C+FE+
Sbjct: 675 TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEK 734
Query: 347 -DLCNFYQDKE--------------GPGWTRVKVKPNMYRAGDHT--TGLGYYLLA---N 386
LC +YQ G G + + N + DHT T G+YL A N
Sbjct: 735 RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSN 794
Query: 387 TKFTSQPGYIGRLYGPSLPG-NLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWS 445
KF + + + P L + + A G +L V I ++N V K+W+
Sbjct: 795 GKFGDTADILTPIISLTGPKCTLVFWTHMNGATVG------SLQVLIKKDN--VTSKLWA 846
Query: 446 VLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGS---------- 495
W +AE+ T++VF + + G VA+DDI+ Q S
Sbjct: 847 QTGQQGAQWKRAEVFLGIRSHTQIVFRAK-RGISYIGDVAVDDISFQDCSPLLSPERKCT 905
Query: 496 ----------CSSSEKL------------------PPPPGECTFEQDECTFTQEKRNRSS 527
C + +KL G C FE D C++ QEK
Sbjct: 906 DHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFD 965
Query: 528 WHRRRGETPTSYTGPKGDHTTG--VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LT 584
W+ + P + T P DHT G G+Y++I++ +A +S P+ K+C +
Sbjct: 966 WNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKII 1025
Query: 585 FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIR 644
F YHMYG G G L++ ++ ++ +L EQ W R + + Q+ FE
Sbjct: 1026 FHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRV 1084
Query: 645 GVSIRSDIAIDDVKFQAGPCGEMEDTTQQ 673
G R DIA+DD+ C + D+ Q+
Sbjct: 1085 GKGQRGDIALDDIVLTEN-CLSLHDSVQE 1112
Score = 83.6 bits (205), Expect = 6e-16
Identities = 132/595 (22%), Positives = 222/595 (37%), Gaps = 139/595 (23%)
Query: 49 EGHYIYVDTSFGKQ-GEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFE 107
+GHY+Y+++S + + A LLSP L A + + + + +L +Y R
Sbjct: 548 KGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIY---RLAIYQRIW 604
Query: 108 DESFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM---- 162
+S +LLW + W+ L++ +S + F+IL+E +G G T IA+ ++
Sbjct: 605 SDSRGQLLWQIFGNQGNRWIRKHLNI-SSRQPFQILVEASVGDGFTGDIAIDDLSFMDCT 663
Query: 163 -----------------------------------TTGYCIE----CDFEEN-------- 175
+ G+CIE CDF+ +
Sbjct: 664 LYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA 723
Query: 176 ----HLCGFVNR----WNPNV-----------NWFVGGG-SIRN-VHSILPQ-DHTFKSE 213
+C F R W + W +G G SI + + P DHT +
Sbjct: 724 SCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTT 783
Query: 214 LGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQQGND--NVFSLYTRDVAGL 271
G Y+Y DS K F + A +++P+ + C ++ G ++ L +D +
Sbjct: 784 DGWYLYADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKD--NV 840
Query: 272 YEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISF---SPV--- 325
++W A W AEV +++F G VA+DDISF SP+
Sbjct: 841 TSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSP 900
Query: 326 --------------HC----------------QNQTELLFSAVEASCNFEQDLCNFYQDK 355
HC ++T + C+FE DLC++ Q+K
Sbjct: 901 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEK 960
Query: 356 EGPGWTRVKVK----PNMYRAGDHTTG--LGYYLLANTKFTSQPGYIGRLYGPSLPGNLQ 409
+ +K A DHT G G+Y+ + F QP R+ P + +
Sbjct: 961 DEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSK 1020
Query: 410 YC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRG-VWMQAEITFKKPMPT 467
C + FHY +YG + A+ + + + Q K+ L +G W + E++
Sbjct: 1021 NCKIIFHYHMYG----NGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDF 1076
Query: 468 KVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEK------LPPPPGECTFEQDEC 516
++ F G +ALDDI + S + +P P G C EC
Sbjct: 1077 QLKFEGRVGK-GQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYREC 1130
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 163 TTGYCIECDFEENH-----LCGFVNRWNPNVNWFVGGGSIRNVHSILPQ-DHTFKSELGH 216
TTG C+FE + C +++W +G S +++P DHT S H
Sbjct: 1435 TTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIG--SRIPAKALIPDSDHTPGSGQ-H 1488
Query: 217 YMYVDSVYVKHFQEVAQLISPLTTAPMAGCLS--FYYQIQQGNDNVFSLYTRDVAGLYEE 274
++YV+S K S A + C ++Y I + + +YT + +GL
Sbjct: 1489 FLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNIL 1548
Query: 275 IWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSP 324
+W W V S+ P +V FE +G + ++ALDDISF+P
Sbjct: 1549 VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP 1598
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 507 GECTFEQDE------CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVG-YYMYIEAS 559
G C FE C+ TQ+ + W P P DHT G G +++Y+ +S
Sbjct: 1437 GSCNFETSSGNWTTACSLTQDSEDDLDW-AIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1495
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLT--FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
G AR+ + S C +FY + G+L VY EE L+W G
Sbjct: 1496 GSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTI-EESGLNILVWSVIG 1554
Query: 618 EQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKF 659
+ W + S ++ FEA + IA+DD+ F
Sbjct: 1555 NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1596
Score = 38.9 bits (89), Expect = 0.016
Identities = 48/230 (20%), Positives = 88/230 (38%), Gaps = 79/230 (34%)
Query: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQ----------ITTSSESLSD 96
N GHYI++ + F +Q +A +S + ++ ++++ +T S+++
Sbjct: 988 NSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTN 1047
Query: 97 PSQLNLYMRFEDESFDRLLWSAKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIA 156
+++ L + E +F W +E S L D F++ EG +G+G IA
Sbjct: 1048 QTKVLLNLTVEQGNF----WRREELS---LFGDED-------FQLKFEGRVGKGQRGDIA 1093
Query: 157 LFEIKMT-------------------TGYC----------------IECDFEEN------ 175
L +I +T TG+C C+F +N
Sbjct: 1094 LDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTD 1153
Query: 176 ------------HLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSE 213
CG+ N N +W +G GS +++ P+DHT +E
Sbjct: 1154 ENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRP--PKDHTLGNE 1201
Score = 37.7 bits (86), Expect = 0.036
Identities = 62/278 (22%), Positives = 105/278 (37%), Gaps = 53/278 (19%)
Query: 424 MSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPT-KVVFMSLCKS----- 477
MSD V++F+ +E W+ S W++A++ + + T K++F S
Sbjct: 1 MSD---VFLFKSKE--EEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFI 55
Query: 478 ------FWDCG------LVALDDITIQLGSCSSSEKLPPPPGECTFEQDECTFTQEKR-- 523
+ CG L + D+ G C + E + +C+ E DE T K
Sbjct: 56 ALDHLWVYACGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT 115
Query: 524 ---------------NRSSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEA--SHMVYG 564
S W +G + P DHT + G ++Y+EA S V
Sbjct: 116 CDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEAQRSPGVAK 175
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWL 624
+ +L++ L S + F+YH+ LSV+ + D + W
Sbjct: 176 LGSPVLTK-LLTASTPCQVQFWYHLSQHSN--LSVFTRTSLDGNLQKQGKIIRFSESQWS 232
Query: 625 RALIEYSCER-----QHQIIFEAIRGVSIRSDIAIDDV 657
A I+ E Q+I EA +S + +A+DD+
Sbjct: 233 HAKIDLIAEAGESTLPFQLILEA-TVLSSNATVALDDI 269
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 3/69 (4%)
Query: 536 PTSYTGPKGDHTTGVGYYMYIEASHM-VYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGT 594
P T DHT ++MY+EA+ + + G KA S R S ++F+Y + T
Sbjct: 1250 PNENTFGSSDHTNW--HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKAT 1307
Query: 595 GLLSVYLKK 603
G + + +K+
Sbjct: 1308 GSIQILIKR 1316
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 51 HYIYVDTSFGKQGEKA-VLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
H++YV++S K+G A + S A C + S+ L +Y E+
Sbjct: 1488 HFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSM---GILKVY-TIEES 1543
Query: 110 SFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMT 163
+ L+WS W S+ L +S+ FK+ E L IAL +I T
Sbjct: 1544 GLNILVWSVIGNKRTGWTYGSVPL-SSNSPFKVAFEADLDGNEDIFIALDDISFT 1597
>gi|119220585 apical early endosomal glycoprotein precursor [Homo
sapiens]
Length = 1137
Score = 126 bits (317), Expect = 6e-29
Identities = 157/589 (26%), Positives = 236/589 (40%), Gaps = 69/589 (11%)
Query: 106 FEDESFDRLLW---SAKEPSDSWLIAS---LDLQNS----SKKFKILIEGVLGQGNTASI 155
+ED S RL W SA+E S A+ L LQ + + ++L + G + +
Sbjct: 503 WEDASVGRLQWRRVSAQESQGSSAAAAGHFLSLQRAWGQLGAEARVLTPLLGPSGPSCEL 562
Query: 156 ALFEIKMTTGYCIECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELG 215
L + + C+FE + C + + +W R V S P DH + G
Sbjct: 563 HLAYYLQSQPREVSCNFERD-TCSWYPGHLSDTHW-------RWVESRGP-DHDHTTGQG 613
Query: 216 HYMYVDSVYVKHFQEVAQLIS-PLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEE 274
H++ +D + A L+S P A CLSF+Y + L R G
Sbjct: 614 HFVLLDPTDPLAWGHSAHLLSRPQVPAAPTECLSFWYHLHGPQIGTLRLAMRR-EGEETH 672
Query: 275 IWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGY---VALDDISFSPVHCQNQT 331
+W W+ A S +++ F G + GY +ALDD++ P C
Sbjct: 673 LWSRSGTQGNRWHEAWATLSHQPGSHAQYQLLFEGLRDGYHGTMALDDVAVRPGPCWAPN 732
Query: 332 ELLFSAVEASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAG----DHTT--GLGYYLLA 385
C+FE C F G G R + + + A DHTT G+Y++
Sbjct: 733 Y---------CSFEDSDCGF--SPGGQGLWRRQANASGHAAWGPPTDHTTETAQGHYMVV 781
Query: 386 NTKFTSQP-GYIGRLYGPS-LPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKI 443
+T + P G L P CL F Y +G L+ TL VY+ E + ++
Sbjct: 782 DTSPDALPRGQTASLTSKEHRPLAQPACLTFWY--HGSLRSPGTLRVYLEERG---RHQV 836
Query: 444 WSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEKLP 503
S+ W + + +VVF ++ VALDD+ +Q G C
Sbjct: 837 LSLSAHGGLAWRLGSMDVQAERAWRVVFEAVAAGVAH-SYVALDDLLLQDGPC------- 888
Query: 504 PPPGECTFEQDECTFTQ---EKRNRSSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEA 558
P PG C FE C ++ SW G TP+ Y P DHT G G++ + E
Sbjct: 889 PQPGSCDFESGLCGWSHLAWPGLGGYSWDWGGGATPSRYPQPPVDHTLGTEAGHFAFFET 948
Query: 559 SHMVYGQKARLL-SRPLRGVSGKHCLTFFYHMYGGG---TGLLSVYLKKEEDSEESLLWR 614
+ G +A L S PL CL F+YHM G L V L + + +W
Sbjct: 949 GVLGPGGRAAWLRSEPLPATPAS-CLRFWYHMGFPEHFYKGELKVLLHSAQG--QLAVWG 1005
Query: 615 RRGEQSISWLRALIEYSCERQHQIIFEA-IRGVSIRSDIAIDDVKFQAG 662
G + WL A +E + ++ QI+FEA + G IA+DDV++ AG
Sbjct: 1006 AGGHRRHQWLEAQVEVASAKEFQIVFEATLGGQPALGPIALDDVEYLAG 1054
Score = 121 bits (304), Expect = 2e-27
Identities = 95/334 (28%), Positives = 152/334 (45%), Gaps = 27/334 (8%)
Query: 339 EASCNFEQDLCNFYQDK-EGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIG 397
E SCNFE+D C++Y W V+ + + DHTTG G+++L + G+
Sbjct: 574 EVSCNFERDTCSWYPGHLSDTHWRWVESRGPDH---DHTTGQGHFVLLDPTDPLAWGHSA 630
Query: 398 RLYG-PSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQ 456
L P +P CL F Y ++G TL + + E + +WS + W +
Sbjct: 631 HLLSRPQVPAAPTECLSFWYHLHG--PQIGTLRLAMRREGE--ETHLWSRSGTQGNRWHE 686
Query: 457 AEITFKKPMPTKVVFMSLCKSFWDC--GLVALDDITIQLGSCSSSEKLPPPPGECTFEQD 514
A T + + L + D G +ALDD+ ++ G C + P C+FE
Sbjct: 687 AWATLSHQPGSHAQYQLLFEGLRDGYHGTMALDDVAVRPGPCWA-------PNYCSFEDS 739
Query: 515 ECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGV--GYYMYIEASH--MVYGQKARLL 570
+C F+ + W R+ + + GP DHTT G+YM ++ S + GQ A L
Sbjct: 740 DCGFSPG--GQGLWRRQANASGHAAWGPPTDHTTETAQGHYMVVDTSPDALPRGQTASLT 797
Query: 571 SRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEY 630
S+ R ++ CLTF+YH G L VYL++ + L G ++W ++
Sbjct: 798 SKEHRPLAQPACLTFWYHGSLRSPGTLRVYLEERGRHQVLSLSAHGG---LAWRLGSMDV 854
Query: 631 SCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
ER +++FEA+ S +A+DD+ Q GPC
Sbjct: 855 QAERAWRVVFEAVAAGVAHSYVALDDLLLQDGPC 888
Score = 90.5 bits (223), Expect = 5e-18
Identities = 86/335 (25%), Positives = 147/335 (43%), Gaps = 42/335 (12%)
Query: 26 CAFEESTCGFD-----------SVLASLPW-------ILNEEGHYIYVDTSFGK--QGEK 65
C+FE+S CGF + W +GHY+ VDTS +G+
Sbjct: 734 CSFEDSDCGFSPGGQGLWRRQANASGHAAWGPPTDHTTETAQGHYMVVDTSPDALPRGQT 793
Query: 66 AVLLSPDLQA-EEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKEPSDS 124
A L S + + + +CL Y SL P L +Y+ E+ ++L + +
Sbjct: 794 ASLTSKEHRPLAQPACLTFWYH-----GSLRSPGTLRVYL--EERGRHQVLSLSAHGGLA 846
Query: 125 WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE---CDFEENHLCGFV 181
W + S+D+Q + + ++++ E V + +AL ++ + G C + CDFE LCG+
Sbjct: 847 WRLGSMDVQ-AERAWRVVFEAVAAGVAHSYVALDDLLLQDGPCPQPGSCDFESG-LCGWS 904
Query: 182 NRWNPNV---NWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPL 238
+ P + +W GGG+ + + P DHT +E GH+ + ++ + A L S
Sbjct: 905 HLAWPGLGGYSWDWGGGATPSRYPQPPVDHTLGTEAGHFAFFETGVLGPGGRAAWLRSEP 964
Query: 239 TTAPMAGCLSFYYQI---QQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWNLAEVEFSA 295
A A CL F+Y + + + G +W A W A+VE ++
Sbjct: 965 LPATPASCLRFWYHMGFPEHFYKGELKVLLHSAQGQL-AVWGAGGHRRHQWLEAQVEVAS 1023
Query: 296 PYPMEVIFEVAFNG-PKGGYVALDDISF-SPVHCQ 328
+++FE G P G +ALDD+ + + HCQ
Sbjct: 1024 AKEFQIVFEATLGGQPALGPIALDDVEYLAGQHCQ 1058
Score = 89.4 bits (220), Expect = 1e-17
Identities = 53/166 (31%), Positives = 83/166 (50%), Gaps = 14/166 (8%)
Query: 504 PPPGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASH-MV 562
P C FE+D C++ + + W GP DHTTG G+++ ++ + +
Sbjct: 572 PREVSCNFERDTCSWYPGHLSDTHWRWVESR------GPDHDHTTGQGHFVLLDPTDPLA 625
Query: 563 YGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSIS 622
+G A LLSRP + CL+F+YH++G G L + +++E EE+ LW R G Q
Sbjct: 626 WGHSAHLLSRPQVPAAPTECLSFWYHLHGPQIGTLRLAMRRE--GEETHLWSRSGTQGNR 683
Query: 623 WLRALIEYS----CERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
W A S Q+Q++FE +R +A+DDV + GPC
Sbjct: 684 WHEAWATLSHQPGSHAQYQLLFEGLRD-GYHGTMALDDVAVRPGPC 728
Score = 63.9 bits (154), Expect = 5e-10
Identities = 46/157 (29%), Positives = 63/157 (40%), Gaps = 5/157 (3%)
Query: 506 PGECTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTG--VGYYMYIEASHMVY 563
P C FEQD C + + SW R R GP DHT G +G+YM +
Sbjct: 63 PFACDFEQDPCGWRDISTSGYSWLRDRAGAALEGPGPHSDHTLGTDLGWYMAVGTHRGKE 122
Query: 564 GQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISW 623
A L S LR + L +YH G L V L +E LW+ G W
Sbjct: 123 ASTAALRSPTLREAASSCKLRLWYHAASGDVAELRVEL--THGAETLTLWQSTGPWGPGW 180
Query: 624 LRALIEYSCER-QHQIIFEAIRGVSIRSDIAIDDVKF 659
+ R ++ F A R + R +A+DD++F
Sbjct: 181 QELAVTTGRIRGDFRVTFSATRNATHRGAVALDDLEF 217
Score = 44.3 bits (103), Expect = 4e-04
Identities = 81/352 (23%), Positives = 122/352 (34%), Gaps = 56/352 (15%)
Query: 341 SCNFEQDLCNFYQ-DKEGPGWTRVKVKPNMYRAG---DHTTG--LGYYLLANTKFTSQPG 394
+C+FEQD C + G W R + + G DHT G LG+Y+ T +
Sbjct: 65 ACDFEQDPCGWRDISTSGYSWLRDRAGAALEGPGPHSDHTLGTDLGWYMAVGTH-RGKEA 123
Query: 395 YIGRLYGPSLPGNLQYC---LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPR 451
L P+L C L +H A S +A E H + P
Sbjct: 124 STAALRSPTLREAASSCKLRLWYHAA-------SGDVAELRVELTHGAETLTLWQSTGPW 176
Query: 452 GV-WMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITI-QLGSCSSSEKLPPPPGEC 509
G W + +T + V S ++ G VALDD+ G + PP C
Sbjct: 177 GPGWQELAVTTGRIRGDFRVTFSATRNATHRGAVALDDLEFWDCGLPTPQANCPPGHHHC 236
Query: 510 TFE-----------QDECTFTQEKR-------------------NRSS-WHRR-RGETPT 537
+ +D C ++ NRS W R R P
Sbjct: 237 QNKVCVEPQQLCDGEDNCGDLSDENPLTCGRHIATDFETGLGPWNRSEGWSRNHRAGGPE 296
Query: 538 SYTGPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LTFFYHMYGGGTGL 596
+ P+ DH+ ++ S G A L S + +C L F+ ++ G G
Sbjct: 297 RPSWPRRDHSRNSAQGSFL-VSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGSEAGC 355
Query: 597 LSVYLKKEEDSEES---LLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRG 645
L ++L+ LL RRRGE +W+R ++ QI+ G
Sbjct: 356 LQLFLQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILLAGQTG 407
Score = 42.7 bits (99), Expect = 0.001
Identities = 84/381 (22%), Positives = 134/381 (35%), Gaps = 88/381 (23%)
Query: 25 SCAFEESTCGFDSVLAS-LPWILNEEGH-------------------YIYVDTSFGKQGE 64
+C FE+ CG+ + S W+ + G Y+ V T GK+
Sbjct: 65 ACDFEQDPCGWRDISTSGYSWLRDRAGAALEGPGPHSDHTLGTDLGWYMAVGTHRGKEAS 124
Query: 65 KAVLLSPDLQAEEWSC-LRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKEP-S 122
A L SP L+ SC LRL Y + D ++L + + E+ LW + P
Sbjct: 125 TAALRSPTLREAASSCKLRLWYHAAS-----GDVAELRVELTHGAETL--TLWQSTGPWG 177
Query: 123 DSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM-------------------T 163
W ++ F++ + ++AL +++
Sbjct: 178 PGWQELAVTTGRIRGDFRVTFSATRNATHRGAVALDDLEFWDCGLPTPQANCPPGHHHCQ 237
Query: 164 TGYCIE----CDFEENHLCGFVNRWNPNV--------------NWFVGGGSIRNVHSILP 205
C+E CD E+N CG ++ NP W G RN + P
Sbjct: 238 NKVCVEPQQLCDGEDN--CGDLSDENPLTCGRHIATDFETGLGPWNRSEGWSRNHRAGGP 295
Query: 206 Q-------DHTFKSELGHYMYVDSVYVKHFQEVAQLISP-LTTAPMAGCLSFYYQIQQGN 257
+ DH+ S G ++ V V A L SP + + C +YQ G+
Sbjct: 296 ERPSWPRRDHSRNSAQGSFL----VSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGS 351
Query: 258 DN---VFSLYTRDVAGLYEEIWKADRPG--NAAWNLAEVEFSAPYPMEVIFEVAFNGPKG 312
+ L T + R G AW V+ + YP +++ GP G
Sbjct: 352 EAGCLQLFLQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILL-AGQTGP-G 409
Query: 313 GYVALDDISFSPVHCQNQTEL 333
G V LDD+ S HC+ +E+
Sbjct: 410 GVVGLDDLILSD-HCRPVSEV 429
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/168 (25%), Positives = 64/168 (38%), Gaps = 31/168 (18%)
Query: 24 GSCAFEESTCGFDSV----LASLPW-------------------ILNEEGHYIYVDTS-F 59
GSC FE CG+ + L W + E GH+ + +T
Sbjct: 892 GSCDFESGLCGWSHLAWPGLGGYSWDWGGGATPSRYPQPPVDHTLGTEAGHFAFFETGVL 951
Query: 60 GKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSA- 118
G G A L S L A SCLR Y + ++ L+ +W A
Sbjct: 952 GPGGRAAWLRSEPLPATPASCLRFWYHMGFPEHFYKGELKVLLH----SAQGQLAVWGAG 1007
Query: 119 KEPSDSWLIASLDLQNSSKKFKILIEGVL-GQGNTASIALFEIKMTTG 165
WL A +++ S+K+F+I+ E L GQ IAL +++ G
Sbjct: 1008 GHRRHQWLEAQVEVA-SAKEFQIVFEATLGGQPALGPIALDDVEYLAG 1054
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 120 bits (300), Expect = 5e-27
Identities = 143/629 (22%), Positives = 237/629 (37%), Gaps = 142/629 (22%)
Query: 168 IECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKH 227
++C+FE +C + + +W G +++ +D+T + GHY+Y++S +
Sbjct: 228 LQCNFETG-ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQA 286
Query: 228 FQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWN 287
FQ+ A L+SP+ A +F + ++ L +Y+ IW +D G W
Sbjct: 287 FQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRL------AIYQRIW-SDSRGQLLWQ 339
Query: 288 L----------AEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFS-------------- 323
+ + S+ P +++ E + G +A+DD+SF
Sbjct: 340 IFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP 399
Query: 324 -----------PVHCQNQTELLF--------------------------SAVEASCNFEQ 346
P H E + S V C+FE+
Sbjct: 400 TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEK 459
Query: 347 -DLCNFYQDKE--------------GPGWTRVKVKPNMYRAGDHT--TGLGYYLLA---N 386
LC +YQ G G + + N + DHT T G+YL A N
Sbjct: 460 RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSN 519
Query: 387 TKFTSQPGYIGRLYGPSLPG-NLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWS 445
KF + + + P L + + A G +L V I ++N V K+W+
Sbjct: 520 GKFGDTADILTPIISLTGPKCTLVFWTHMNGATVG------SLQVLIKKDN--VTSKLWA 571
Query: 446 VLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGS---------- 495
W +AE+ T++VF + + G VA+DDI+ Q S
Sbjct: 572 QTGQQGAQWKRAEVFLGIRSHTQIVFRAK-RGISYIGDVAVDDISFQDCSPLLSPERKCT 630
Query: 496 ----------CSSSEKL------------------PPPPGECTFEQDECTFTQEKRNRSS 527
C + +KL G C FE D C++ QEK
Sbjct: 631 DHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFD 690
Query: 528 WHRRRGETPTSYTGPKGDHTTG--VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LT 584
W+ + P + T P DHT G G+Y++I + +A +S P+ K+C +
Sbjct: 691 WNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKII 750
Query: 585 FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIR 644
F YHMYG G G L++ ++ ++ +L EQ W R + + Q+ FE
Sbjct: 751 FHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRV 809
Query: 645 GVSIRSDIAIDDVKFQAGPCGEMEDTTQQ 673
G R DIA+DD+ C + D+ Q+
Sbjct: 810 GKGQRGDIALDDIVLTEN-CLSLHDSVQE 837
Score = 119 bits (297), Expect = 1e-26
Identities = 139/606 (22%), Positives = 231/606 (38%), Gaps = 120/606 (19%)
Query: 169 ECDFEENHLCGFVNRWNPNVNWFVGGGSIRNV---HSILPQDHTFKSELGHYMYVDSVYV 225
+CDFE N F + +W S + H P+DH+ + GH+M++
Sbjct: 18 KCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSS 77
Query: 226 KHFQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEE--IWKADRPGN 283
+Q VA+L SP + GC+ ++ G + + ++ IW+
Sbjct: 78 SLWQ-VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
Query: 284 AAWNLAEVEFSA-PYPMEVIFEVAFNGPKGGYVALDDISFSPV----------------- 325
W A ++ P + + G G A+DDI F
Sbjct: 137 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 196
Query: 326 -----------------HCQNQTELLFSAVEASCNFEQDLCNFYQD-KEGPGWTRVKVKP 367
C ++T+ + A E CNFE +CN+ QD K+ WTR +
Sbjct: 197 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT 256
Query: 368 NMYRAG---DHTTGL--GYYLLANTKFTSQPGYIGRLYGPSLPG-NLQYC-LRFHYAIYG 420
G D+T G G+YL + L P L + + C RF+Y ++G
Sbjct: 257 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 316
Query: 421 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLC----- 475
K LA+Y + + +W + + W++ + P +++ +
Sbjct: 317 --KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFT 374
Query: 476 -------KSFWDCGLVALD-------------DITIQLGSCSSSEKLPPPPGECTFEQDE 515
SF DC L + +T+ +C+ +E + G C + +
Sbjct: 375 GDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQK 434
Query: 516 CTF------------------TQEKRNRSSWHR---------------RRGETPTSYTG- 541
C F + EKR+ W++ G + + G
Sbjct: 435 CDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGE 494
Query: 542 ----PKGDHT--TGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LTFFYHMYGGGT 594
P DHT T G+Y+Y ++S+ +G A +L+ P+ ++G C L F+ HM G
Sbjct: 495 ENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILT-PIISLTGPKCTLVFWTHMNGATV 553
Query: 595 GLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAI 654
G L V +KK D+ S LW + G+Q W RA + QI+F A RG+S D+A+
Sbjct: 554 GSLQVLIKK--DNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAV 611
Query: 655 DDVKFQ 660
DD+ FQ
Sbjct: 612 DDISFQ 617
Score = 109 bits (273), Expect = 7e-24
Identities = 100/372 (26%), Positives = 156/372 (41%), Gaps = 56/372 (15%)
Query: 340 ASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAG--------DHTTGL--GYYLLANTKF 389
+ C+FE + C++++ G + ++ + A DH+ G+++ K
Sbjct: 17 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKK- 75
Query: 390 TSQPGYIGRLYGPSLPGNLQYC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLE 448
+S + +L P+ C L F + YG + L +++ EN IW VL
Sbjct: 76 SSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHM--ENSHDSTVIWRVLY 133
Query: 449 SPRGVWMQAEITFKK-PMPTKVVFMSLCKSFWDCGLVALDDITIQ-------LGSCSSS- 499
+ W++A I + P + + +D G+ A+DDI + SC
Sbjct: 134 NQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYD-GVSAIDDIRFENCTLPLPAESCEGLD 192
Query: 500 -----------EKLP-----------------PPPGECTFEQDECTFTQEKRNRSSWHRR 531
EKL P +C FE C + Q+ ++ W R
Sbjct: 193 HFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRN 252
Query: 532 RGETPTSYTGPKGDHTTGV--GYYMYIEASH-MVYGQKARLLSRPLRGVSGKHC-LTFFY 587
+G TPT TGP D+T G G+Y+YIE+S + A LLS L K C F+Y
Sbjct: 253 QGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYY 312
Query: 588 HMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVS 647
HM+G L++Y + DS LLW+ G Q W+R + S + QI+ EA G
Sbjct: 313 HMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDG 372
Query: 648 IRSDIAIDDVKF 659
DIAIDD+ F
Sbjct: 373 FTGDIAIDDLSF 384
Score = 85.9 bits (211), Expect = 1e-16
Identities = 133/595 (22%), Positives = 223/595 (37%), Gaps = 139/595 (23%)
Query: 49 EGHYIYVDTSFGKQ-GEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFE 107
+GHY+Y+++S + + A LLSP L A + + + + +L +Y R
Sbjct: 273 KGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIY---RLAIYQRIW 329
Query: 108 DESFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM---- 162
+S +LLW + W+ L++ +S + F+IL+E +G G T IA+ ++
Sbjct: 330 SDSRGQLLWQIFGNQGNRWIRKHLNI-SSRQPFQILVEASVGDGFTGDIAIDDLSFMDCT 388
Query: 163 -----------------------------------TTGYCIE----CDFEEN-------- 175
+ G+CIE CDF+ +
Sbjct: 389 LYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA 448
Query: 176 ----HLCGFVNR----WNPNV-----------NWFVGGG-SIRN-VHSILPQ-DHTFKSE 213
+C F R W + W +G G SI + + P DHT +
Sbjct: 449 SCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTT 508
Query: 214 LGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQQGND--NVFSLYTRDVAGL 271
G Y+Y DS K F + A +++P+ + C ++ G ++ L +D +
Sbjct: 509 DGWYLYADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKD--NV 565
Query: 272 YEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISF---SPV--- 325
++W A W AEV +++F G VA+DDISF SP+
Sbjct: 566 TSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSP 625
Query: 326 --------------HC----------------QNQTELLFSAVEASCNFEQDLCNFYQDK 355
HC ++T + C+FE DLC++ Q+K
Sbjct: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEK 685
Query: 356 EGPGWTRVKVK----PNMYRAGDHTTG--LGYYLLANTKFTSQPGYIGRLYGPSLPGNLQ 409
+ +K A DHT G G+Y+ N+ F QP R+ P + +
Sbjct: 686 DEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSK 745
Query: 410 YC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRG-VWMQAEITFKKPMPT 467
C + FHY +YG + A+ + + + Q K+ L +G W + E++
Sbjct: 746 NCKIIFHYHMYG----NGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDF 801
Query: 468 KVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEK------LPPPPGECTFEQDEC 516
++ F G +ALDDI + S + +P P G C EC
Sbjct: 802 QLKFEGRVGK-GQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYREC 855
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 163 TTGYCIECDFEENH-----LCGFVNRWNPNVNWFVGGGSIRNVHSILPQ-DHTFKSELGH 216
TTG C+FE + C +++W +G S +++P DHT S H
Sbjct: 1160 TTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIG--SRIPAKALIPDSDHTPGSGQ-H 1213
Query: 217 YMYVDSVYVKHFQEVAQLISPLTTAPMAGCLS--FYYQIQQGNDNVFSLYTRDVAGLYEE 274
++YV+S K S A + C ++Y I + + +YT + +GL
Sbjct: 1214 FLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNIL 1273
Query: 275 IWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSP 324
+W W V S+ P +V FE +G + ++ALDDISF+P
Sbjct: 1274 VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP 1323
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 507 GECTFEQDE------CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVG-YYMYIEAS 559
G C FE C+ TQ+ + W P P DHT G G +++Y+ +S
Sbjct: 1162 GSCNFETSSGNWTTACSLTQDSEDDLDW-AIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1220
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLT--FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
G AR+ + S C +FY + G+L VY EE L+W G
Sbjct: 1221 GSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTI-EESGLNILVWSVIG 1279
Query: 618 EQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKF 659
+ W + S ++ FEA + IA+DD+ F
Sbjct: 1280 NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1321
Score = 39.7 bits (91), Expect = 0.009
Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 79/230 (34%)
Query: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQ----------ITTSSESLSD 96
N GHYI++++ F +Q +A +S + ++ ++++ +T S+++
Sbjct: 713 NSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTN 772
Query: 97 PSQLNLYMRFEDESFDRLLWSAKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIA 156
+++ L + E +F W +E S L D F++ EG +G+G IA
Sbjct: 773 QTKVLLNLTVEQGNF----WRREELS---LFGDED-------FQLKFEGRVGKGQRGDIA 818
Query: 157 LFEIKMT-------------------TGYC----------------IECDFEEN------ 175
L +I +T TG+C C+F +N
Sbjct: 819 LDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTG 878
Query: 176 ------------HLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSE 213
CG+ N N +W +G GS +++ P+DHT +E
Sbjct: 879 ENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRP--PKDHTLGNE 926
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 51 HYIYVDTSFGKQGEKA-VLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
H++YV++S K+G A + S A C + S+ L +Y E+
Sbjct: 1213 HFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSM---GILKVY-TIEES 1268
Query: 110 SFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMT 163
+ L+WS W S+ L +S+ FK+ E L IAL +I T
Sbjct: 1269 GLNILVWSVIGNKRTGWTYGSVPL-SSNSPFKVAFEADLDGNEDIFIALDDISFT 1322
Score = 29.6 bits (65), Expect = 9.7
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 536 PTSYTGPKGDHTTGVGYYMYIEASHM-VYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGT 594
P T DH ++MY+EA+ + + G KA S R S ++F+Y + T
Sbjct: 975 PNENTFGSSDHMNW--HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKAT 1032
Query: 595 GLLSVYLKK 603
G + + +K+
Sbjct: 1033 GSIQILIKR 1041
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 105 bits (263), Expect = 1e-22
Identities = 68/182 (37%), Positives = 92/182 (50%), Gaps = 16/182 (8%)
Query: 509 CTFEQDE-CTFTQEKRNRSSWHRR----RGETPTSYTGPKGDHT-TGVGYYMYIEASH-M 561
C FE C FTQ+ + W ++ R T TGP D + + G+YMYIE S
Sbjct: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
Query: 562 VYGQKARLLS--------RPLRGVSGKHCLTFFYHMYGGGTGLLSVYLK-KEEDSEESLL 612
+ G+KARLLS P + +C +FFYHMYG G+L+VYL+ K + + E+ L
Sbjct: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
Query: 613 WRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQ 672
W G + W A + Q+IFE IRG I DIAIDDV G C + + T+
Sbjct: 868 WSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATK 927
Query: 673 QS 674
S
Sbjct: 928 NS 929
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/179 (26%), Positives = 79/179 (44%), Gaps = 22/179 (12%)
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVH---SILPQDHTFKSELGHYMYVDSVYVK 226
C FE+ ++C F N +W + RN + P S+ G YMY+++ +
Sbjct: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
Query: 227 HFQEVAQLISPL-TTAP--------MAGCLSFYYQIQQGNDNVFSLYTR--DVAGLYEEI 275
E A+L+SP+ + AP A C SF+Y + + V ++Y R + +
Sbjct: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
Query: 276 WKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG----GYVALDDISFSPVHCQNQ 330
W + WN A V YP+ F++ F G +G G +A+DD+S + C Q
Sbjct: 868 WSSSGNKGQRWNEAHVNI---YPI-TSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 922
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 339 EASCNFEQ-DLCNFYQDK-EGPGWTR-------VKVKPNMYRAGDHTTGL-GYYLLANTK 388
E C FE ++C F QD + WT+ K PN D + G+Y+ T
Sbjct: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETS 804
Query: 389 FTSQPGYIGRLYGPSL---------PGNLQYCLRFHYAIYGFLKMSDTLAVYI-FEENHV 438
G RL P P N YC F Y +YG + L VY+ +
Sbjct: 805 RPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYG--QHIGVLNVYLRLKGQTT 862
Query: 439 VQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSS 498
++ +WS + W +A + +++F + + G +A+DD++I G C+
Sbjct: 863 IENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGECAK 921
Query: 499 SE 500
+
Sbjct: 922 QD 923
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 18/137 (13%)
Query: 47 NEEGHYIYVDTSFGK-QGEKAVLLSPDLQAEEWS---------CLRLVYQITTSSESLSD 96
++EG Y+Y++TS + +GEKA LLSP + C Y + +
Sbjct: 793 SKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGV-- 850
Query: 97 PSQLNLYMRFEDES-FDRLLWSAK-EPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTAS 154
LN+Y+R + ++ + LWS+ W A +++ + F+++ EG+ G G
Sbjct: 851 ---LNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGD 906
Query: 155 IALFEIKMTTGYCIECD 171
IA+ ++ + G C + D
Sbjct: 907 IAIDDVSIAEGECAKQD 923
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 105 bits (263), Expect = 1e-22
Identities = 68/182 (37%), Positives = 92/182 (50%), Gaps = 16/182 (8%)
Query: 509 CTFEQDE-CTFTQEKRNRSSWHRR----RGETPTSYTGPKGDHT-TGVGYYMYIEASH-M 561
C FE C FTQ+ + W ++ R T TGP D + + G+YMYIE S
Sbjct: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
Query: 562 VYGQKARLLS--------RPLRGVSGKHCLTFFYHMYGGGTGLLSVYLK-KEEDSEESLL 612
+ G+KARLLS P + +C +FFYHMYG G+L+VYL+ K + + E+ L
Sbjct: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
Query: 613 WRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQ 672
W G + W A + Q+IFE IRG I DIAIDDV G C + + T+
Sbjct: 639 WSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATK 698
Query: 673 QS 674
S
Sbjct: 699 NS 700
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/179 (26%), Positives = 79/179 (44%), Gaps = 22/179 (12%)
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVH---SILPQDHTFKSELGHYMYVDSVYVK 226
C FE+ ++C F N +W + RN + P S+ G YMY+++ +
Sbjct: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
Query: 227 HFQEVAQLISPL-TTAP--------MAGCLSFYYQIQQGNDNVFSLYTR--DVAGLYEEI 275
E A+L+SP+ + AP A C SF+Y + + V ++Y R + +
Sbjct: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
Query: 276 WKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG----GYVALDDISFSPVHCQNQ 330
W + WN A V YP+ F++ F G +G G +A+DD+S + C Q
Sbjct: 639 WSSSGNKGQRWNEAHVNI---YPI-TSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQ 693
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/182 (24%), Positives = 72/182 (39%), Gaps = 23/182 (12%)
Query: 339 EASCNFEQ-DLCNFYQDK-EGPGWTR-------VKVKPNMYRAGDHTTGL-GYYLLANTK 388
E C FE ++C F QD + WT+ K PN D + G+Y+ T
Sbjct: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETS 575
Query: 389 FTSQPGYIGRLYGPSL---------PGNLQYCLRFHYAIYGFLKMSDTLAVYI-FEENHV 438
G RL P P N YC F Y +YG + L VY+ +
Sbjct: 576 RPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYG--QHIGVLNVYLRLKGQTT 633
Query: 439 VQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSS 498
++ +WS + W +A + +++F + + G +A+DD++I G C+
Sbjct: 634 IENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIE-GDIAIDDVSIAEGECAK 692
Query: 499 SE 500
+
Sbjct: 693 QD 694
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 18/137 (13%)
Query: 47 NEEGHYIYVDTSFGK-QGEKAVLLSPDLQAEEWS---------CLRLVYQITTSSESLSD 96
++EG Y+Y++TS + +GEKA LLSP + C Y + +
Sbjct: 564 SKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGV-- 621
Query: 97 PSQLNLYMRFEDES-FDRLLWSAK-EPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTAS 154
LN+Y+R + ++ + LWS+ W A +++ + F+++ EG+ G G
Sbjct: 622 ---LNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGD 677
Query: 155 IALFEIKMTTGYCIECD 171
IA+ ++ + G C + D
Sbjct: 678 IAIDDVSIAEGECAKQD 694
>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
Length = 2812
Score = 95.5 bits (236), Expect = 1e-19
Identities = 125/522 (23%), Positives = 205/522 (39%), Gaps = 53/522 (10%)
Query: 169 ECDFEENH--LCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVK 226
+CDFE++ LC + + +W G + P + + G Y++++S
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGG--YPNGEGSYLHMESNSF- 96
Query: 227 HFQEVAQLISPLTTAPMAGCLSFYYQ---IQQGNDNVFSLYTRDVAGLYEEIWKADRPGN 283
H VA+L+SP C+ F + + G L + + + +WK
Sbjct: 97 HRGGVARLLSPDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQR 156
Query: 284 AAWNLAEVEFSAPYPMEVIFEVAFNGPKGGY----VALDDISFSPVHCQNQTELLFSAVE 339
+W L V A + + + F G +G +ALD +S C +
Sbjct: 157 PSWMLTTVTVPAGFTLPT--RLMFEGTRGSTAYLDIALDALSIRRGSCNRVCMM------ 208
Query: 340 ASCNFE--QDLCNF--YQDKEGPGWTRVKV---KPNMYRAGDHTT-GLGYYLLANTKFTS 391
+C+F+ DLC++ G WT+ K KP + GD ++ G G Y+L + K +
Sbjct: 209 QTCSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVGPDGDFSSPGSGCYMLLDPK-NA 267
Query: 392 QPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEE--NHVVQEKIWSVLES 449
+PG L P + FHY + G S A++I+ + + ++S
Sbjct: 268 RPGQKAVLLSPVSLSSGCLSFSFHYILRG---QSPGAALHIYASVLGSIRKHTLFSGQPG 324
Query: 450 PRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEKLPPPPGEC 509
P W + + + + + + VA+D +I E P +C
Sbjct: 325 PN--WQAVSVNYTAVGRIQFAVVGVFGKTPEPA-VAVDATSI----APCGEGFP----QC 373
Query: 510 TFEQDE---CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVY-GQ 565
FE + C + Q + W P GP G G+Y+Y+EA GQ
Sbjct: 374 DFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPAGGFPNAGGHYIYLEADEFSQAGQ 433
Query: 566 KARLLSRPLRGVSGKHCLTFFYHMYGGGTG-LLSVYLKKEEDSEESLLWRRRGEQSISWL 624
RL+SRP G C+ F YHMYG G G +L + L S LW+R G Q W
Sbjct: 434 SVRLVSRPF-CAPGDICVEFAYHMYGLGEGTMLELLLGSPAGSPPIPLWKRVGSQRPYWQ 492
Query: 625 RALIEYSCERQH--QIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+ Q Q+IF+ I+G + S +A+ + G C
Sbjct: 493 NTSVTVPSGHQQPMQLIFKGIQGSNTASVVAMGFILINPGTC 534
Score = 79.7 bits (195), Expect = 8e-15
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 8/167 (4%)
Query: 508 ECTFEQDE---CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
+C FE D C ++Q + W R G +PT TG G + G G Y+++E++ G
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSFHRG 99
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYG--GGTGLLSVYLKKEEDSEESLLWRRRGEQSIS 622
ARLLS P G C+ F +HM+G G L + L EE +LW+ Q S
Sbjct: 100 GVARLLS-PDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPS 158
Query: 623 WLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEM 667
W+ + +++FE RG + DIA+D + + G C +
Sbjct: 159 WMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALSIRRGSCNRV 205
Score = 73.6 bits (179), Expect = 6e-13
Identities = 84/345 (24%), Positives = 144/345 (41%), Gaps = 29/345 (8%)
Query: 338 VEASCNFEQD---LCNFYQ-DKEGPGWTRVKVKP---NMYRAGDHTTGLGYYLLANTKFT 390
V C+FE D LC++ Q + W R + G + G G YL +
Sbjct: 37 VLTQCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSF 96
Query: 391 SQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESP 450
+ G + RL P L C+ F + ++G + + + E + +W +
Sbjct: 97 HRGG-VARLLSPDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 451 RGVWMQAEITFKK--PMPTKVVFMSLCKS--FWDCGLVALDDITIQLGSCSSSEKLPPPP 506
R WM +T +PT+++F S + D +ALD ++I+ GSC+ +
Sbjct: 156 RPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLD---IALDALSIRRGSCNRVCMMQT-- 210
Query: 507 GECTFE--QDECTFTQ-EKRNRSSWHRRRGETPTSYTGPKGDHTT-GVGYYMYIEASHMV 562
C+F+ D C +T + + W +++G + GP GD ++ G G YM ++ +
Sbjct: 211 --CSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVGPDGDFSSPGSGCYMLLDPKNAR 268
Query: 563 YGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTG-LLSVYLKKEEDSEESLLWRRRGEQSI 621
GQKA LLS P+ SG +F Y + G G L +Y + L+ G+
Sbjct: 269 PGQKAVLLS-PVSLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLF--SGQPGP 325
Query: 622 SWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGE 666
+W + Y+ + Q + G + +A+D PCGE
Sbjct: 326 NWQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSI--APCGE 368
Score = 68.6 bits (166), Expect = 2e-11
Identities = 113/487 (23%), Positives = 190/487 (39%), Gaps = 54/487 (11%)
Query: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRF 106
N EG Y++++++ +G A LLSPDL + C+ + + LS +QL L +
Sbjct: 83 NGEGSYLHMESNSFHRGGVARLLSPDLWEQGPLCVHFAHHMF----GLSWGAQLRLLLLS 138
Query: 107 EDESF--DRLL--WSAKEPSDSWLIASLDL-QNSSKKFKILIEGVLGQGNTASIALFEIK 161
+E D L W+ + P SW++ ++ + + +++ EG G IAL +
Sbjct: 139 GEEGRRPDVLWKHWNTQRP--SWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS 196
Query: 162 MTTGYCIE------CDFE-ENHLCGFVNRWNPNVN---WFVGGGSIRNVHSILPQDHTFK 211
+ G C C F+ N LC + W P + W GS + P
Sbjct: 197 IRRGSCNRVCMMQTCSFDIPNDLCDWT--WIPTASGAKWTQKKGS-SGKPGVGPDGDFSS 253
Query: 212 SELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSF-YYQIQQGND--NVFSLYTRDV 268
G YM +D + Q+ A L+SP++ + +GCLSF ++ I +G +Y +
Sbjct: 254 PGSGCYMLLDPKNARPGQK-AVLLSPVSLS--SGCLSFSFHYILRGQSPGAALHIYASVL 310
Query: 269 AGLYEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSPVHCQ 328
+ + + +PG W V ++A ++ F VA+D S +P
Sbjct: 311 GSIRKHTLFSGQPG-PNWQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSIAPC--- 366
Query: 329 NQTELLFSAVEASCNFEQD---LCNFYQDK-EGPGWT---RVKVKPNMYRAGDHTTGLGY 381
C+FE + C++ Q +G W + M AG G+
Sbjct: 367 -------GEGFPQCDFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPAGGFPNAGGH 419
Query: 382 YLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQE 441
Y+ SQ G RL C+ F Y +YG L L + +
Sbjct: 420 YIYLEADEFSQAGQSVRLVSRPFCAPGDICVEFAYHMYG-LGEGTMLELLLGSPAGSPPI 478
Query: 442 KIWSVLESPRGVWMQAEITFKK--PMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
+W + S R W +T P +++F + S +VA+ I I G+C
Sbjct: 479 PLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSN-TASVVAMGFILINPGTCPVK 537
Query: 500 --EKLPP 504
+LPP
Sbjct: 538 VLPELPP 544
>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
Length = 2721
Score = 95.5 bits (236), Expect = 1e-19
Identities = 125/522 (23%), Positives = 205/522 (39%), Gaps = 53/522 (10%)
Query: 169 ECDFEENH--LCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVK 226
+CDFE++ LC + + +W G + P + + G Y++++S
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGG--YPNGEGSYLHMESNSF- 96
Query: 227 HFQEVAQLISPLTTAPMAGCLSFYYQ---IQQGNDNVFSLYTRDVAGLYEEIWKADRPGN 283
H VA+L+SP C+ F + + G L + + + +WK
Sbjct: 97 HRGGVARLLSPDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQR 156
Query: 284 AAWNLAEVEFSAPYPMEVIFEVAFNGPKGGY----VALDDISFSPVHCQNQTELLFSAVE 339
+W L V A + + + F G +G +ALD +S C +
Sbjct: 157 PSWMLTTVTVPAGFTLPT--RLMFEGTRGSTAYLDIALDALSIRRGSCNRVCMM------ 208
Query: 340 ASCNFE--QDLCNF--YQDKEGPGWTRVKV---KPNMYRAGDHTT-GLGYYLLANTKFTS 391
+C+F+ DLC++ G WT+ K KP + GD ++ G G Y+L + K +
Sbjct: 209 QTCSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVGPDGDFSSPGSGCYMLLDPK-NA 267
Query: 392 QPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEE--NHVVQEKIWSVLES 449
+PG L P + FHY + G S A++I+ + + ++S
Sbjct: 268 RPGQKAVLLSPVSLSSGCLSFSFHYILRG---QSPGAALHIYASVLGSIRKHTLFSGQPG 324
Query: 450 PRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEKLPPPPGEC 509
P W + + + + + + VA+D +I E P +C
Sbjct: 325 PN--WQAVSVNYTAVGRIQFAVVGVFGKTPEPA-VAVDATSI----APCGEGFP----QC 373
Query: 510 TFEQDE---CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVY-GQ 565
FE + C + Q + W P GP G G+Y+Y+EA GQ
Sbjct: 374 DFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPAGGFPNAGGHYIYLEADEFSQAGQ 433
Query: 566 KARLLSRPLRGVSGKHCLTFFYHMYGGGTG-LLSVYLKKEEDSEESLLWRRRGEQSISWL 624
RL+SRP G C+ F YHMYG G G +L + L S LW+R G Q W
Sbjct: 434 SVRLVSRPF-CAPGDICVEFAYHMYGLGEGTMLELLLGSPAGSPPIPLWKRVGSQRPYWQ 492
Query: 625 RALIEYSCERQH--QIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+ Q Q+IF+ I+G + S +A+ + G C
Sbjct: 493 NTSVTVPSGHQQPMQLIFKGIQGSNTASVVAMGFILINPGTC 534
Score = 79.7 bits (195), Expect = 8e-15
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 8/167 (4%)
Query: 508 ECTFEQDE---CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
+C FE D C ++Q + W R G +PT TG G + G G Y+++E++ G
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSFHRG 99
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYG--GGTGLLSVYLKKEEDSEESLLWRRRGEQSIS 622
ARLLS P G C+ F +HM+G G L + L EE +LW+ Q S
Sbjct: 100 GVARLLS-PDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQRPS 158
Query: 623 WLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEM 667
W+ + +++FE RG + DIA+D + + G C +
Sbjct: 159 WMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALSIRRGSCNRV 205
Score = 73.6 bits (179), Expect = 6e-13
Identities = 84/345 (24%), Positives = 144/345 (41%), Gaps = 29/345 (8%)
Query: 338 VEASCNFEQD---LCNFYQ-DKEGPGWTRVKVKP---NMYRAGDHTTGLGYYLLANTKFT 390
V C+FE D LC++ Q + W R + G + G G YL +
Sbjct: 37 VLTQCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSF 96
Query: 391 SQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESP 450
+ G + RL P L C+ F + ++G + + + E + +W +
Sbjct: 97 HRGG-VARLLSPDLWEQGPLCVHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 451 RGVWMQAEITFKK--PMPTKVVFMSLCKS--FWDCGLVALDDITIQLGSCSSSEKLPPPP 506
R WM +T +PT+++F S + D +ALD ++I+ GSC+ +
Sbjct: 156 RPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLD---IALDALSIRRGSCNRVCMMQT-- 210
Query: 507 GECTFE--QDECTFTQ-EKRNRSSWHRRRGETPTSYTGPKGDHTT-GVGYYMYIEASHMV 562
C+F+ D C +T + + W +++G + GP GD ++ G G YM ++ +
Sbjct: 211 --CSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVGPDGDFSSPGSGCYMLLDPKNAR 268
Query: 563 YGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTG-LLSVYLKKEEDSEESLLWRRRGEQSI 621
GQKA LLS P+ SG +F Y + G G L +Y + L+ G+
Sbjct: 269 PGQKAVLLS-PVSLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLF--SGQPGP 325
Query: 622 SWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGE 666
+W + Y+ + Q + G + +A+D PCGE
Sbjct: 326 NWQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSI--APCGE 368
Score = 68.6 bits (166), Expect = 2e-11
Identities = 113/487 (23%), Positives = 190/487 (39%), Gaps = 54/487 (11%)
Query: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRF 106
N EG Y++++++ +G A LLSPDL + C+ + + LS +QL L +
Sbjct: 83 NGEGSYLHMESNSFHRGGVARLLSPDLWEQGPLCVHFAHHMF----GLSWGAQLRLLLLS 138
Query: 107 EDESF--DRLL--WSAKEPSDSWLIASLDL-QNSSKKFKILIEGVLGQGNTASIALFEIK 161
+E D L W+ + P SW++ ++ + + +++ EG G IAL +
Sbjct: 139 GEEGRRPDVLWKHWNTQRP--SWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS 196
Query: 162 MTTGYCIE------CDFE-ENHLCGFVNRWNPNVN---WFVGGGSIRNVHSILPQDHTFK 211
+ G C C F+ N LC + W P + W GS + P
Sbjct: 197 IRRGSCNRVCMMQTCSFDIPNDLCDWT--WIPTASGAKWTQKKGS-SGKPGVGPDGDFSS 253
Query: 212 SELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSF-YYQIQQGND--NVFSLYTRDV 268
G YM +D + Q+ A L+SP++ + +GCLSF ++ I +G +Y +
Sbjct: 254 PGSGCYMLLDPKNARPGQK-AVLLSPVSLS--SGCLSFSFHYILRGQSPGAALHIYASVL 310
Query: 269 AGLYEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSPVHCQ 328
+ + + +PG W V ++A ++ F VA+D S +P
Sbjct: 311 GSIRKHTLFSGQPG-PNWQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSIAPC--- 366
Query: 329 NQTELLFSAVEASCNFEQD---LCNFYQDK-EGPGWT---RVKVKPNMYRAGDHTTGLGY 381
C+FE + C++ Q +G W + M AG G+
Sbjct: 367 -------GEGFPQCDFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPAGGFPNAGGH 419
Query: 382 YLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQE 441
Y+ SQ G RL C+ F Y +YG L L + +
Sbjct: 420 YIYLEADEFSQAGQSVRLVSRPFCAPGDICVEFAYHMYG-LGEGTMLELLLGSPAGSPPI 478
Query: 442 KIWSVLESPRGVWMQAEITFKK--PMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
+W + S R W +T P +++F + S +VA+ I I G+C
Sbjct: 479 PLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSN-TASVVAMGFILINPGTCPVK 537
Query: 500 --EKLPP 504
+LPP
Sbjct: 538 VLPELPP 544
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 92.8 bits (229), Expect = 9e-19
Identities = 61/165 (36%), Positives = 89/165 (53%), Gaps = 10/165 (6%)
Query: 509 CTFEQDE-CTFTQEKRNRSSWHRRRGETP----TSYTGPKGDHT-TGVGYYMYIEASH-M 561
C FE ++ C +TQ+ + W R+ T + TGP D + T GYYM+IE S
Sbjct: 753 CHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPR 812
Query: 562 VYGQKARLLSRPLRGVSGK-HCLTFFYHMYGGGTGLLSVYLK-KEEDSEESLLWRRRGEQ 619
G +ARL+S PL S K +C++FFYHMYG G L++ ++ + + + ++ W G +
Sbjct: 813 ELGDRARLVS-PLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNK 871
Query: 620 SISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
W +A + S QIIFE +RG DIAIDDV + G C
Sbjct: 872 GNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGEC 916
Score = 57.4 bits (137), Expect = 4e-08
Identities = 43/171 (25%), Positives = 76/171 (44%), Gaps = 9/171 (5%)
Query: 170 CDFEENHLCGFVNRWNPNVNW----FVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYV 225
C FE+ +CG+ N +W + R+ ++ P D + E G+YM++++
Sbjct: 753 CHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE-GYYMFIETSRP 811
Query: 226 KHFQEVAQLISPLTTAPMA-GCLSFYYQIQQGNDNVFSLY--TRDVAGLYEEIWKADRPG 282
+ + A+L+SPL A C+SF+Y + + +L +R+ L W
Sbjct: 812 RELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNK 871
Query: 283 NAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSPVHC-QNQTE 332
W A V S P ++IFE G +A+DD++ C + QT+
Sbjct: 872 GNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTD 922
Score = 56.6 bits (135), Expect = 7e-08
Identities = 47/175 (26%), Positives = 78/175 (44%), Gaps = 15/175 (8%)
Query: 341 SCNFEQD-LCNFYQD-KEGPGWTRV-------KVKPNMYRAGDHT-TGLGYYLLANTKFT 390
+C+FE + +C + QD + WTR K PN D + T GYY+ T
Sbjct: 752 TCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRP 811
Query: 391 SQPGYIGRLYGPSLPGNLQ-YCLRFHYAIYGFLKMSDTLAVYIFEENH-VVQEKIWSVLE 448
+ G RL P + + YC+ F Y +YG K +L + + N + WS+
Sbjct: 812 RELGDRARLVSPLYNASAKFYCVSFFYHMYG--KHIGSLNLLVRSRNKGALDTHAWSLSG 869
Query: 449 SPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEKLP 503
+ VW QA + P +++F + + G +A+DD+T++ G C + P
Sbjct: 870 NKGNVWQQAHVPISPSGPFQIIFEGV-RGPGYLGDIAIDDVTLKKGECPRKQTDP 923
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 10/123 (8%)
Query: 49 EGHYIYVDTSFGKQ-GEKAVLLSPDLQAE-EWSCLRLVYQITTSSESLSDPSQLNLYMRF 106
EG+Y++++TS ++ G++A L+SP A ++ C+ Y + LNL +R
Sbjct: 800 EGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIG-----SLNLLVRS 854
Query: 107 EDE-SFDRLLWSAK-EPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTT 164
++ + D WS + W A + + S F+I+ EGV G G IA+ ++ +
Sbjct: 855 RNKGALDTHAWSLSGNKGNVWQQAHVPISPSGP-FQIIFEGVRGPGYLGDIAIDDVTLKK 913
Query: 165 GYC 167
G C
Sbjct: 914 GEC 916
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 83.6 bits (205), Expect = 6e-16
Identities = 49/158 (31%), Positives = 80/158 (50%), Gaps = 4/158 (2%)
Query: 509 CTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYGQKAR 568
C FE C + Q+ + + W R +G T + +TGP DHT G YI G++ R
Sbjct: 347 CNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQER 406
Query: 569 --LLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRA 626
LLS PL CL+F+YHMYG LS+ + +++ E++ ++++ G +W
Sbjct: 407 VGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKT-VFQKEGNYGDNWNYG 465
Query: 627 LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+ + + ++ F A + I SDIA+DD+ G C
Sbjct: 466 QVTLNETVKFKVAFNAFKN-KILSDIALDDISLTYGIC 502
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 16/202 (7%)
Query: 318 DDISFSPVHCQNQTELLFSAVEASCNFEQDLCNFYQD-KEGPGWTRVK---VKPNMYRAG 373
D + F+ + + L + + +CNFE C + QD + W R++ P
Sbjct: 323 DYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNF 382
Query: 374 DHTTG--LGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVY 431
DHT G G+Y+ T + +G L P P CL F Y +YG + L++
Sbjct: 383 DHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYG--ENVHKLSIN 440
Query: 432 IFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITI 491
I + + +++ ++ + W ++T + + KV F + +ALDDI++
Sbjct: 441 ISNDQN-MEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKI--LSDIALDDISL 497
Query: 492 QLGSCSSS-----EKLPPPPGE 508
G C+ S +P PP E
Sbjct: 498 TYGICNGSLYPEPTLVPTPPPE 519
Score = 48.9 bits (115), Expect = 2e-05
Identities = 43/159 (27%), Positives = 69/159 (43%), Gaps = 8/159 (5%)
Query: 168 IECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKH 227
I C+FE+ C +V N + W GS + + DHTF + G Y+ +
Sbjct: 345 INCNFEDG-FCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGR 403
Query: 228 FQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWN 287
+ V L PL CLSF+Y + N + S+ + + + +++ + WN
Sbjct: 404 QERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWN 463
Query: 288 LAEVEFSAPYPMEVIFEVAFNGPKG---GYVALDDISFS 323
+V + V F+VAFN K +ALDDIS +
Sbjct: 464 YGQVTLNE----TVKFKVAFNAFKNKILSDIALDDISLT 498
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 73.9 bits (180), Expect = 4e-13
Identities = 47/124 (37%), Positives = 67/124 (54%), Gaps = 5/124 (4%)
Query: 537 TSYTGPKGDHTTGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGL 596
TS TGP DHT G G ++Y +A G+ ARL+S + + HC+TF+YHM G G
Sbjct: 677 TSKTGPIQDHT-GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGT 735
Query: 597 LSVYLKKEEDSE-ESLLWRRRGEQSISWL--RALIEYSCERQHQIIFEAIRGVSIRSDIA 653
L V L+ ++ E + L+W G Q W R L+ S + +Q+IFE G IA
Sbjct: 736 LRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSL-KLYQVIFEGEIGKGNLGGIA 794
Query: 654 IDDV 657
+DD+
Sbjct: 795 VDDI 798
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/117 (27%), Positives = 62/117 (52%), Gaps = 8/117 (6%)
Query: 49 EGHYIYVDTSFGKQGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFE 107
+G++IY ++G+ A L+SP + ++ + C+ Y + S S L + +R++
Sbjct: 689 DGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHM-----SGSHVGTLRVKLRYQ 743
Query: 108 D-ESFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM 162
E +D+L+W A D W + L S K ++++ EG +G+GN IA+ +I +
Sbjct: 744 KPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISI 800
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform
2 precursor [Homo sapiens]
Length = 1452
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/165 (29%), Positives = 76/165 (46%), Gaps = 14/165 (8%)
Query: 507 GECTFEQ--DECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
G C F++ C ++Q + + +W E + T P D G +M + AS G
Sbjct: 25 GGCLFDEPYSTCGYSQSEGDDFNW-----EQVNTLTKPTSDPWMPSGSFMLVNASGRPEG 79
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYGGGT---GLLSVYLKKEEDSEESLLWRRRGEQSI 621
Q+A LL L+ + HC+ F Y + GLL+VY+K + +W G+ +
Sbjct: 80 QRAHLLLPQLKE-NDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTR 138
Query: 622 SWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+W RA + S +Q+IFE I + +AID+VK PC
Sbjct: 139 TWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPC 182
Score = 60.1 bits (144), Expect = 7e-09
Identities = 48/179 (26%), Positives = 83/179 (46%), Gaps = 22/179 (12%)
Query: 7 LLALQALQLAGALDLPAGSCAFEE--STCGFD---------------SVLASLPWILNEE 49
L L L L A + +G C F+E STCG+ + S PW+
Sbjct: 8 LATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWM--PS 65
Query: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
G ++ V+ S +G++A LL P L+ + C+ Y + SS+S S P LN+Y++ +
Sbjct: 66 GSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFV--SSKSNSPPGLLNVYVKVNNG 123
Query: 110 SFDRLLWS-AKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYC 167
+W+ + +P+ +W A L + F +I V+ G+ +A+ E+K+ C
Sbjct: 124 PLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPC 182
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/158 (24%), Positives = 69/158 (43%), Gaps = 16/158 (10%)
Query: 170 CDFEENH-LCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHF 228
C F+E + CG+ + NW V+++ G +M V++
Sbjct: 27 CLFDEPYSTCGYSQSEGDDFNW-------EQVNTLTKPTSDPWMPSGSFMLVNASGRPEG 79
Query: 229 QEVAQLISPLTTAPMAGCLSFYYQIQQGNDN---VFSLYTRDVAG-LYEEIWKADRPGNA 284
Q A L+ P C+ F+Y + +++ + ++Y + G L IW
Sbjct: 80 QR-AHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTR 138
Query: 285 AWNLAEVEFSAPYP--MEVIFEVAFNGPKGGYVALDDI 320
WN AE+ S +P +VIFEV +G + GY+A+D++
Sbjct: 139 TWNRAELAISTFWPNFYQVIFEVITSGHQ-GYLAIDEV 175
Score = 38.9 bits (89), Expect = 0.016
Identities = 34/149 (22%), Positives = 57/149 (38%), Gaps = 6/149 (4%)
Query: 352 YQDKEGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYC 411
Y EG + +V D G ++L N + G L P L N +C
Sbjct: 38 YSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPE-GQRAHLLLPQLKENDTHC 96
Query: 412 LRFHYAIYGFLKMSDTLA-VYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPT--K 468
+ FHY + L VY+ N + IW++ P W +AE+ P +
Sbjct: 97 IDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQ 156
Query: 469 VVFMSLCKSFWDCGLVALDDITIQLGSCS 497
V+F + G +A+D++ + C+
Sbjct: 157 VIFEVITSGHQ--GYLAIDEVKVLGHPCT 183
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform
1 precursor [Homo sapiens]
Length = 1465
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/165 (29%), Positives = 76/165 (46%), Gaps = 14/165 (8%)
Query: 507 GECTFEQ--DECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
G C F++ C ++Q + + +W E + T P D G +M + AS G
Sbjct: 25 GGCLFDEPYSTCGYSQSEGDDFNW-----EQVNTLTKPTSDPWMPSGSFMLVNASGRPEG 79
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMYGGGT---GLLSVYLKKEEDSEESLLWRRRGEQSI 621
Q+A LL L+ + HC+ F Y + GLL+VY+K + +W G+ +
Sbjct: 80 QRAHLLLPQLKE-NDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTR 138
Query: 622 SWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+W RA + S +Q+IFE I + +AID+VK PC
Sbjct: 139 TWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPC 182
Score = 60.1 bits (144), Expect = 7e-09
Identities = 48/179 (26%), Positives = 83/179 (46%), Gaps = 22/179 (12%)
Query: 7 LLALQALQLAGALDLPAGSCAFEE--STCGFD---------------SVLASLPWILNEE 49
L L L L A + +G C F+E STCG+ + S PW+
Sbjct: 8 LATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWM--PS 65
Query: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
G ++ V+ S +G++A LL P L+ + C+ Y + SS+S S P LN+Y++ +
Sbjct: 66 GSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFV--SSKSNSPPGLLNVYVKVNNG 123
Query: 110 SFDRLLWS-AKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYC 167
+W+ + +P+ +W A L + F +I V+ G+ +A+ E+K+ C
Sbjct: 124 PLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPC 182
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/158 (24%), Positives = 69/158 (43%), Gaps = 16/158 (10%)
Query: 170 CDFEENH-LCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKHF 228
C F+E + CG+ + NW V+++ G +M V++
Sbjct: 27 CLFDEPYSTCGYSQSEGDDFNW-------EQVNTLTKPTSDPWMPSGSFMLVNASGRPEG 79
Query: 229 QEVAQLISPLTTAPMAGCLSFYYQIQQGNDN---VFSLYTRDVAG-LYEEIWKADRPGNA 284
Q A L+ P C+ F+Y + +++ + ++Y + G L IW
Sbjct: 80 QR-AHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTR 138
Query: 285 AWNLAEVEFSAPYP--MEVIFEVAFNGPKGGYVALDDI 320
WN AE+ S +P +VIFEV +G + GY+A+D++
Sbjct: 139 TWNRAELAISTFWPNFYQVIFEVITSGHQ-GYLAIDEV 175
Score = 38.9 bits (89), Expect = 0.016
Identities = 34/149 (22%), Positives = 57/149 (38%), Gaps = 6/149 (4%)
Query: 352 YQDKEGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYC 411
Y EG + +V D G ++L N + G L P L N +C
Sbjct: 38 YSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPE-GQRAHLLLPQLKENDTHC 96
Query: 412 LRFHYAIYGFLKMSDTLA-VYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPT--K 468
+ FHY + L VY+ N + IW++ P W +AE+ P +
Sbjct: 97 IDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQ 156
Query: 469 VVFMSLCKSFWDCGLVALDDITIQLGSCS 497
V+F + G +A+D++ + C+
Sbjct: 157 VIFEVITSGHQ--GYLAIDEVKVLGHPCT 183
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform
1 precursor [Homo sapiens]
Length = 1436
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 16/172 (9%)
Query: 505 PPGECTFEQDE-----CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEAS 559
P CTFE+ C ++Q + + W + R + G + G Y+ + S
Sbjct: 23 PAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVR-----IHPGTRAPADLPHGSYLMVNTS 77
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLTFFYHMY---GGGTGLLSVYLKKEEDSEESLLWRRR 616
GQ+A ++ + L + HC+ F Y +Y G G L VY++ S +W
Sbjct: 78 QHAPGQRAHVIFQSL-SENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMT 136
Query: 617 GEQSISWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGE 666
G W +A + S ++Q++FEA+ R + +DD+ + PC +
Sbjct: 137 GSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAK 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 340 ASCNFEQDL-----CNFYQDK-EGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQP 393
A C FE+ C + Q + + W +V++ P D G YL+ NT P
Sbjct: 25 AGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGS--YLMVNTS-QHAP 81
Query: 394 GYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSD-TLAVYIFEENHVVQEKIWSVLESPRG 452
G + SL N +C++F Y +Y S TL VY+ + +W++ S
Sbjct: 82 GQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGR 141
Query: 453 VWMQAEITFKK--PMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
W QAE+ P +V+F +L S G + LDDI + C+ +
Sbjct: 142 QWHQAELAVSTFWPNEYQVLFEALI-SPDRRGYMGLDDILLLSYPCAKA 189
Score = 34.3 bits (77), Expect = 0.39
Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 3/82 (3%)
Query: 249 FYYQIQQGNDNVFSLYTRDVAG-LYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEV 305
F Y + +Y R G L +W W+ AE+ S +P E V+FE
Sbjct: 105 FLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEA 164
Query: 306 AFNGPKGGYVALDDISFSPVHC 327
+ + GY+ LDDI C
Sbjct: 165 LISPDRRGYMGLDDILLLSYPC 186
Score = 33.1 bits (74), Expect = 0.88
Identities = 38/189 (20%), Positives = 70/189 (37%), Gaps = 32/189 (16%)
Query: 4 RGVLLALQALQLAGALDLPAGSCAFEEST-----CGFDSVL------------------A 40
+ ++LAL A + PA C FEE++ C + A
Sbjct: 5 QALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPA 64
Query: 41 SLPWILNEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQL 100
LP G Y+ V+TS G++A ++ L + C++ Y + S P L
Sbjct: 65 DLP-----HGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFL--YSRDGHSPGTL 117
Query: 101 NLYMRFEDESFDRLLWS-AKEPSDSWLIASLDLQNS-SKKFKILIEGVLGQGNTASIALF 158
+Y+R +W+ W A L + ++++L E ++ + L
Sbjct: 118 GVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLD 177
Query: 159 EIKMTTGYC 167
+I + + C
Sbjct: 178 DILLLSYPC 186
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform
2 precursor [Homo sapiens]
Length = 1442
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 16/172 (9%)
Query: 505 PPGECTFEQDE-----CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEAS 559
P CTFE+ C ++Q + + W + R + G + G Y+ + S
Sbjct: 23 PAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVR-----IHPGTRAPADLPHGSYLMVNTS 77
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLTFFYHMY---GGGTGLLSVYLKKEEDSEESLLWRRR 616
GQ+A ++ + L + HC+ F Y +Y G G L VY++ S +W
Sbjct: 78 QHAPGQRAHVIFQSL-SENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMT 136
Query: 617 GEQSISWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGE 666
G W +A + S ++Q++FEA+ R + +DD+ + PC +
Sbjct: 137 GSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAK 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 340 ASCNFEQDL-----CNFYQDK-EGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQP 393
A C FE+ C + Q + + W +V++ P D G YL+ NT P
Sbjct: 25 AGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGS--YLMVNTS-QHAP 81
Query: 394 GYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSD-TLAVYIFEENHVVQEKIWSVLESPRG 452
G + SL N +C++F Y +Y S TL VY+ + +W++ S
Sbjct: 82 GQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGR 141
Query: 453 VWMQAEITFKK--PMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
W QAE+ P +V+F +L S G + LDDI + C+ +
Sbjct: 142 QWHQAELAVSTFWPNEYQVLFEALI-SPDRRGYMGLDDILLLSYPCAKA 189
Score = 34.3 bits (77), Expect = 0.39
Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 3/82 (3%)
Query: 249 FYYQIQQGNDNVFSLYTRDVAG-LYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEV 305
F Y + +Y R G L +W W+ AE+ S +P E V+FE
Sbjct: 105 FLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEA 164
Query: 306 AFNGPKGGYVALDDISFSPVHC 327
+ + GY+ LDDI C
Sbjct: 165 LISPDRRGYMGLDDILLLSYPC 186
Score = 33.1 bits (74), Expect = 0.88
Identities = 38/189 (20%), Positives = 70/189 (37%), Gaps = 32/189 (16%)
Query: 4 RGVLLALQALQLAGALDLPAGSCAFEEST-----CGFDSVL------------------A 40
+ ++LAL A + PA C FEE++ C + A
Sbjct: 5 QALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPA 64
Query: 41 SLPWILNEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQL 100
LP G Y+ V+TS G++A ++ L + C++ Y + S P L
Sbjct: 65 DLP-----HGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFL--YSRDGHSPGTL 117
Query: 101 NLYMRFEDESFDRLLWS-AKEPSDSWLIASLDLQNS-SKKFKILIEGVLGQGNTASIALF 158
+Y+R +W+ W A L + ++++L E ++ + L
Sbjct: 118 GVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLD 177
Query: 159 EIKMTTGYC 167
+I + + C
Sbjct: 178 DILLLSYPC 186
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform
3 precursor [Homo sapiens]
Length = 1446
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 16/172 (9%)
Query: 505 PPGECTFEQDE-----CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEAS 559
P CTFE+ C ++Q + + W + R + G + G Y+ + S
Sbjct: 23 PAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVR-----IHPGTRAPADLPHGSYLMVNTS 77
Query: 560 HMVYGQKARLLSRPLRGVSGKHCLTFFYHMY---GGGTGLLSVYLKKEEDSEESLLWRRR 616
GQ+A ++ + L + HC+ F Y +Y G G L VY++ S +W
Sbjct: 78 QHAPGQRAHVIFQSL-SENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMT 136
Query: 617 GEQSISWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGE 666
G W +A + S ++Q++FEA+ R + +DD+ + PC +
Sbjct: 137 GSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAK 188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 46/169 (27%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 340 ASCNFEQDL-----CNFYQDK-EGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQP 393
A C FE+ C + Q + + W +V++ P D G YL+ NT P
Sbjct: 25 AGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGS--YLMVNTS-QHAP 81
Query: 394 GYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSD-TLAVYIFEENHVVQEKIWSVLESPRG 452
G + SL N +C++F Y +Y S TL VY+ + +W++ S
Sbjct: 82 GQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGR 141
Query: 453 VWMQAEITFKK--PMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
W QAE+ P +V+F +L S G + LDDI + C+ +
Sbjct: 142 QWHQAELAVSTFWPNEYQVLFEALI-SPDRRGYMGLDDILLLSYPCAKA 189
Score = 34.3 bits (77), Expect = 0.39
Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 3/82 (3%)
Query: 249 FYYQIQQGNDNVFSLYTRDVAG-LYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEV 305
F Y + +Y R G L +W W+ AE+ S +P E V+FE
Sbjct: 105 FLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEA 164
Query: 306 AFNGPKGGYVALDDISFSPVHC 327
+ + GY+ LDDI C
Sbjct: 165 LISPDRRGYMGLDDILLLSYPC 186
Score = 33.1 bits (74), Expect = 0.88
Identities = 38/189 (20%), Positives = 70/189 (37%), Gaps = 32/189 (16%)
Query: 4 RGVLLALQALQLAGALDLPAGSCAFEEST-----CGFDSVL------------------A 40
+ ++LAL A + PA C FEE++ C + A
Sbjct: 5 QALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPA 64
Query: 41 SLPWILNEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQL 100
LP G Y+ V+TS G++A ++ L + C++ Y + S P L
Sbjct: 65 DLP-----HGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFL--YSRDGHSPGTL 117
Query: 101 NLYMRFEDESFDRLLWS-AKEPSDSWLIASLDLQNS-SKKFKILIEGVLGQGNTASIALF 158
+Y+R +W+ W A L + ++++L E ++ + L
Sbjct: 118 GVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLD 177
Query: 159 EIKMTTGYC 167
+I + + C
Sbjct: 178 DILLLSYPC 186
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform
2 precursor [Homo sapiens]
Length = 1441
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/180 (27%), Positives = 80/180 (44%), Gaps = 22/180 (12%)
Query: 501 KLPPPPGE--------CTFEQ--DECTFTQEK-RNRSSWHRRRGETPTSYTGPKGDHTTG 549
+LPP PG C+F++ C ++ N +W E ++ P D
Sbjct: 16 QLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTW-----EQINTWEKPMLDQAVP 70
Query: 550 VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYG---GGTGLLSVYLKKEED 606
G +M + +S GQKA LL L+ + HC+ F Y+ G L+VY+K
Sbjct: 71 TGSFMMVNSSGRASGQKAHLLLPTLKE-NDTHCIDFHYYFSSRDRSSPGALNVYVKVNGG 129
Query: 607 SEESLLWRRRGEQSISWLRALIEYSCERQH--QIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+ + +W G + W++A + S H Q+IFE++ IA+D+V+ A PC
Sbjct: 130 PQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPC 189
Score = 32.3 bits (72), Expect = 1.5
Identities = 29/126 (23%), Positives = 52/126 (41%), Gaps = 5/126 (3%)
Query: 374 DHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMS-DTLAVYI 432
D G +++ N+ + G L P+L N +C+ FHY + S L VY+
Sbjct: 66 DQAVPTGSFMMVNSSGRAS-GQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYV 124
Query: 433 FEENHVVQEKIWSVLESPRGVWMQAEITFKKPMP--TKVVFMSLCKSFWDCGLVALDDIT 490
+W+V W++AE+ P +V+F S+ G +A+D++
Sbjct: 125 KVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLK-GHPGYIAVDEVR 183
Query: 491 IQLGSC 496
+ C
Sbjct: 184 VLAHPC 189
Score = 31.2 bits (69), Expect = 3.3
Identities = 29/126 (23%), Positives = 49/126 (38%), Gaps = 7/126 (5%)
Query: 215 GHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQ---QGNDNVFSLYTRDVAGL 271
G +M V+S Q+ A L+ P C+ F+Y + + ++Y + G
Sbjct: 72 GSFMMVNSSGRASGQK-AHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGP 130
Query: 272 Y-EEIWKADRPGNAAWNLAEVEFSAPYP--MEVIFEVAFNGPKGGYVALDDISFSPVHCQ 328
+W W AE+ S +P +VIFE GY+A+D++ C+
Sbjct: 131 QGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCR 190
Query: 329 NQTELL 334
L
Sbjct: 191 KAPHFL 196
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform
1 precursor [Homo sapiens]
Length = 1460
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/180 (27%), Positives = 80/180 (44%), Gaps = 22/180 (12%)
Query: 501 KLPPPPGE--------CTFEQ--DECTFTQEK-RNRSSWHRRRGETPTSYTGPKGDHTTG 549
+LPP PG C+F++ C ++ N +W E ++ P D
Sbjct: 16 QLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTW-----EQINTWEKPMLDQAVP 70
Query: 550 VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYG---GGTGLLSVYLKKEED 606
G +M + +S GQKA LL L+ + HC+ F Y+ G L+VY+K
Sbjct: 71 TGSFMMVNSSGRASGQKAHLLLPTLKE-NDTHCIDFHYYFSSRDRSSPGALNVYVKVNGG 129
Query: 607 SEESLLWRRRGEQSISWLRALIEYSCERQH--QIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
+ + +W G + W++A + S H Q+IFE++ IA+D+V+ A PC
Sbjct: 130 PQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPC 189
Score = 32.3 bits (72), Expect = 1.5
Identities = 29/126 (23%), Positives = 52/126 (41%), Gaps = 5/126 (3%)
Query: 374 DHTTGLGYYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMS-DTLAVYI 432
D G +++ N+ + G L P+L N +C+ FHY + S L VY+
Sbjct: 66 DQAVPTGSFMMVNSSGRAS-GQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYV 124
Query: 433 FEENHVVQEKIWSVLESPRGVWMQAEITFKKPMP--TKVVFMSLCKSFWDCGLVALDDIT 490
+W+V W++AE+ P +V+F S+ G +A+D++
Sbjct: 125 KVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLK-GHPGYIAVDEVR 183
Query: 491 IQLGSC 496
+ C
Sbjct: 184 VLAHPC 189
Score = 31.2 bits (69), Expect = 3.3
Identities = 29/126 (23%), Positives = 49/126 (38%), Gaps = 7/126 (5%)
Query: 215 GHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQ---QGNDNVFSLYTRDVAGL 271
G +M V+S Q+ A L+ P C+ F+Y + + ++Y + G
Sbjct: 72 GSFMMVNSSGRASGQK-AHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGP 130
Query: 272 Y-EEIWKADRPGNAAWNLAEVEFSAPYP--MEVIFEVAFNGPKGGYVALDDISFSPVHCQ 328
+W W AE+ S +P +VIFE GY+A+D++ C+
Sbjct: 131 QGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCR 190
Query: 329 NQTELL 334
L
Sbjct: 191 KAPHFL 196
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform
a [Homo sapiens]
Length = 1446
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 13/165 (7%)
Query: 507 GECTFEQDE--CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
G CTF+ C + Q+ + W + P Y P+ G YM +++S G
Sbjct: 34 GGCTFDDGPGACDYHQDLYDDFEWVHVSAQEP-HYLPPEMPQ----GSYMIVDSSDHDPG 88
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMY---GGGTGLLSVYLKKEEDSEESLLWRRRGEQSI 621
+KARL P + HC+ F Y +Y G G L++ ++ + + +W G
Sbjct: 89 EKARL-QLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGR 147
Query: 622 SWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
WLRA + S ++Q+IFEA IAIDD++ + PC
Sbjct: 148 DWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPC 192
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/144 (31%), Positives = 59/144 (40%), Gaps = 11/144 (7%)
Query: 200 VHSILPQDHTFKSEL--GHYMYVDSVYVKHFQ-EVAQLISPLTTAPMAGCLSFYYQI--Q 254
VH + H E+ G YM VDS H E A+L P C+ F Y + Q
Sbjct: 58 VHVSAQEPHYLPPEMPQGSYMIVDSS--DHDPGEKARLQLPTMKENDTHCIDFSYLLYSQ 115
Query: 255 QG-NDNVFSLYTRDVAG-LYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGP 310
+G N ++ R G L IW W AE+ S +P E VIFE +G
Sbjct: 116 KGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGG 175
Query: 311 KGGYVALDDISFSPVHCQNQTELL 334
+ GY+A+DDI C L
Sbjct: 176 RSGYIAIDDIQVLSYPCDKSPHFL 199
Score = 44.3 bits (103), Expect = 4e-04
Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 11/161 (6%)
Query: 341 SCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLY 400
+C++ QDL Y D E W V + Y + G Y++ ++ PG RL
Sbjct: 44 ACDYHQDL---YDDFE---WVHVSAQEPHYLPPEMPQGS--YMIVDSS-DHDPGEKARLQ 94
Query: 401 GPSLPGNLQYCLRFHYAIYGFLKMS-DTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEI 459
P++ N +C+ F Y +Y ++ TL + + + IW+V W++AE+
Sbjct: 95 LPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAEL 154
Query: 460 TFKKPMPTKV-VFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
P + V S G +A+DDI + C S
Sbjct: 155 AVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKS 195
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/180 (24%), Positives = 73/180 (40%), Gaps = 21/180 (11%)
Query: 7 LLALQALQLAGALD--LPAGSCAFEESTCGFD------------SVLASLPWILNEE--- 49
LL L L G+ AG C F++ D V A P L E
Sbjct: 15 LLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQ 74
Query: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
G Y+ VD+S GEKA L P ++ + C+ Y + S+ +P LN+ +R
Sbjct: 75 GSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLL--YSQKGLNPGTLNILVRVNKG 132
Query: 110 SFDRLLWSAKE-PSDSWLIASLDLQNS-SKKFKILIEGVLGQGNTASIALFEIKMTTGYC 167
+W+ WL A L + +++++ E + G + IA+ +I++ + C
Sbjct: 133 PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPC 192
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform
b [Homo sapiens]
Length = 1440
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/165 (28%), Positives = 74/165 (44%), Gaps = 13/165 (7%)
Query: 507 GECTFEQDE--CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYG 564
G CTF+ C + Q+ + W + P Y P+ G YM +++S G
Sbjct: 34 GGCTFDDGPGACDYHQDLYDDFEWVHVSAQEP-HYLPPEMPQ----GSYMIVDSSDHDPG 88
Query: 565 QKARLLSRPLRGVSGKHCLTFFYHMY---GGGTGLLSVYLKKEEDSEESLLWRRRGEQSI 621
+KARL P + HC+ F Y +Y G G L++ ++ + + +W G
Sbjct: 89 EKARL-QLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGR 147
Query: 622 SWLRALIEYSC--ERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
WLRA + S ++Q+IFEA IAIDD++ + PC
Sbjct: 148 DWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPC 192
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/144 (31%), Positives = 59/144 (40%), Gaps = 11/144 (7%)
Query: 200 VHSILPQDHTFKSEL--GHYMYVDSVYVKHFQ-EVAQLISPLTTAPMAGCLSFYYQI--Q 254
VH + H E+ G YM VDS H E A+L P C+ F Y + Q
Sbjct: 58 VHVSAQEPHYLPPEMPQGSYMIVDSS--DHDPGEKARLQLPTMKENDTHCIDFSYLLYSQ 115
Query: 255 QG-NDNVFSLYTRDVAG-LYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGP 310
+G N ++ R G L IW W AE+ S +P E VIFE +G
Sbjct: 116 KGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGG 175
Query: 311 KGGYVALDDISFSPVHCQNQTELL 334
+ GY+A+DDI C L
Sbjct: 176 RSGYIAIDDIQVLSYPCDKSPHFL 199
Score = 44.3 bits (103), Expect = 4e-04
Identities = 40/161 (24%), Positives = 67/161 (41%), Gaps = 11/161 (6%)
Query: 341 SCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYIGRLY 400
+C++ QDL Y D E W V + Y + G Y++ ++ PG RL
Sbjct: 44 ACDYHQDL---YDDFE---WVHVSAQEPHYLPPEMPQGS--YMIVDSS-DHDPGEKARLQ 94
Query: 401 GPSLPGNLQYCLRFHYAIYGFLKMS-DTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEI 459
P++ N +C+ F Y +Y ++ TL + + + IW+V W++AE+
Sbjct: 95 LPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAEL 154
Query: 460 TFKKPMPTKV-VFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
P + V S G +A+DDI + C S
Sbjct: 155 AVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKS 195
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/180 (24%), Positives = 73/180 (40%), Gaps = 21/180 (11%)
Query: 7 LLALQALQLAGALD--LPAGSCAFEESTCGFD------------SVLASLPWILNEE--- 49
LL L L G+ AG C F++ D V A P L E
Sbjct: 15 LLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQ 74
Query: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFEDE 109
G Y+ VD+S GEKA L P ++ + C+ Y + S+ +P LN+ +R
Sbjct: 75 GSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLL--YSQKGLNPGTLNILVRVNKG 132
Query: 110 SFDRLLWSAKE-PSDSWLIASLDLQNS-SKKFKILIEGVLGQGNTASIALFEIKMTTGYC 167
+W+ WL A L + +++++ E + G + IA+ +I++ + C
Sbjct: 133 PLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPC 192
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 58.5 bits (140), Expect = 2e-08
Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 24/248 (9%)
Query: 449 SPRGVWMQAEIT---FKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLG-SCS--SSEKL 502
SP G+ M+ E+ + PT KS ++ + G +CS + L
Sbjct: 579 SPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDL 638
Query: 503 PPPPG-ECTFE--QDEC--TFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIE 557
P G C F+ ++ C + K R++W +P T P + ++ ++
Sbjct: 639 QLPSGFNCNFDFLEEPCGWMYDHAKWLRTTW--ASSSSPNDRTFPDDRN------FLRLQ 690
Query: 558 ASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
+ GQ ARL+S P+ C+ F Y GG L V +E E LLW R
Sbjct: 691 SDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVV--REASQESKLLWVIRE 748
Query: 618 EQSISWLRA-LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPCGEMEDTTQQSSG 676
+Q W +I S + ++QI+FE + G +IAIDD++ +E+ + S
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDV--PLENCMEPISA 806
Query: 677 YSEDLNEI 684
++ D+ EI
Sbjct: 807 FAVDIPEI 814
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 28/170 (16%)
Query: 19 LDLPAG-SCAFE--ESTCGFDSVLASLPWILN--------------EEGHYIYVDTSFGK 61
L LP+G +C F+ E CG+ + W+ ++ +++ + + +
Sbjct: 638 LQLPSGFNCNFDFLEEPCGW--MYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQR 695
Query: 62 QGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
+G+ A L+SP + C+ YQ T + L + E +LLW +E
Sbjct: 696 EGQYARLISPPVHLPRSPVCMEFQYQATGGRG-------VALQVVREASQESKLLWVIRE 748
Query: 121 PSDS-WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE 169
W + L + +++I+ EGV+G+G + IA+ +I+++T +E
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE 798
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 205 PQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAG-CLSFYYQIQQGNDNVFSL 263
P D TF + +++ + S + Q A+LISP P + C+ F YQ G +
Sbjct: 675 PNDRTFPDDR-NFLRLQSDSQREGQ-YARLISPPVHLPRSPVCMEFQYQATGGRGVALQV 732
Query: 264 YTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGPKGGYVALDDIS 321
R+ + + +W W + + Y ME ++FE + G +A+DDI
Sbjct: 733 -VREASQESKLLWVIREDQGGEWKHGRIILPS-YDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Query: 322 FS 323
S
Sbjct: 791 IS 792
>gi|153070264 meprin A beta [Homo sapiens]
Length = 701
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/198 (25%), Positives = 90/198 (45%), Gaps = 22/198 (11%)
Query: 478 FWDCGLVALDDITIQLGSCSSSEKLPPPPGECTFE-QDECTFTQEKRNRSSWHRRRGETP 536
F D L+ L+ QL +CSSS C+FE ++ C Q + + W +R + P
Sbjct: 241 FSDSDLLKLN----QLYNCSSSLSFMD---SCSFELENVCGMIQSSGDNADW-QRVSQVP 292
Query: 537 TSYTGPKGDHTT-----GVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYG 591
GP+ DH+ G G++M+ ++S + G A L SR L G CL F+ + G
Sbjct: 293 R---GPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSG 349
Query: 592 GGTGLLSVYLKK----EEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVS 647
+ L++Y+++ D +L+ + + SW + ++ +++FE +G
Sbjct: 350 SESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSG 409
Query: 648 IR-SDIAIDDVKFQAGPC 664
++IDD+ C
Sbjct: 410 ASLGGLSIDDINLSETRC 427
Score = 43.1 bits (100), Expect = 8e-04
Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 31/189 (16%)
Query: 157 LFEIKMTTGYCIECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSEL-- 214
L+ + + C FE ++CG + N +W + V DH+ +
Sbjct: 252 LYNCSSSLSFMDSCSFELENVCGMIQSSGDNADW----QRVSQVPRGPESDHSNMGQCQG 307
Query: 215 -GHYMYVDSVYVKHFQEVAQLISPLTTAPMAG--CLSFYYQIQQGNDNVFSLYTRDVAG- 270
G +M+ DS V ++ T P G CL FY + ++Y R+ +
Sbjct: 308 SGFFMHFDSSSVN--VGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSAD 365
Query: 271 -------LYEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKG-----GYVALD 318
L EEI + +W L V V+FE G KG G +++D
Sbjct: 366 NVDGNLTLVEEIKEIP---TGSWQLYHVTLKVTKKFRVVFE----GRKGSGASLGGLSID 418
Query: 319 DISFSPVHC 327
DI+ S C
Sbjct: 419 DINLSETRC 427
Score = 40.0 bits (92), Expect = 0.007
Identities = 36/125 (28%), Positives = 65/125 (52%), Gaps = 13/125 (10%)
Query: 50 GHYIYVDTSFGKQGEKAVLLSPDLQAEE-WSCLRLVYQITTSSESLSDPSQLNLYMR-FE 107
G +++ D+S G AVL S L + + CL+ Y + SES QLN+Y+R +
Sbjct: 309 GFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQF-YLYNSGSES----DQLNIYIREYS 363
Query: 108 DESFDRLLWSAKE----PSDSWLIASLDLQNSSKKFKILIEGVLGQG-NTASIALFEIKM 162
++ D L +E P+ SW + + L+ +KKF+++ EG G G + +++ +I +
Sbjct: 364 ADNVDGNLTLVEEIKEIPTGSWQLYHVTLK-VTKKFRVVFEGRKGSGASLGGLSIDDINL 422
Query: 163 TTGYC 167
+ C
Sbjct: 423 SETRC 427
Score = 36.2 bits (82), Expect = 0.10
Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 24/172 (13%)
Query: 341 SCNFE-QDLCNFYQDK-EGPGWTRVKVKPNMYRAGDHTT-----GLGYYLLANTKFTSQP 393
SC+FE +++C Q + W RV P + DH+ G G+++ ++ +
Sbjct: 264 SCSFELENVCGMIQSSGDNADWQRVSQVPRGPES-DHSNMGQCQGSGFFMHFDSSSVNV- 321
Query: 394 GYIGRLYGPSL-PGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENH--------VVQEKIW 444
G L +L P CL+F+ +Y SD L +YI E + +V+E
Sbjct: 322 GATAVLESRTLYPKRGFQCLQFY--LYNSGSESDQLNIYIREYSADNVDGNLTLVEE--- 376
Query: 445 SVLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSC 496
+ E P G W +T K +VVF S G +++DDI + C
Sbjct: 377 -IKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRC 427
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/222 (26%), Positives = 94/222 (42%), Gaps = 22/222 (9%)
Query: 449 SPRGVWMQAEIT---FKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLG-SCS--SSEKL 502
SP G+ M+ E+ + PT KS ++ + G +CS + L
Sbjct: 579 SPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDL 638
Query: 503 PPPPG-ECTFE--QDEC--TFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIE 557
P G C F+ ++ C + K R++W +P T P + ++ ++
Sbjct: 639 QLPSGFNCNFDFLEEPCGWMYDHAKWLRTTW--ASSSSPNDRTFPDDRN------FLRLQ 690
Query: 558 ASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
+ GQ ARL+S P+ C+ F Y GG L V +E E LLW R
Sbjct: 691 SDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVV--REASQESKLLWVIRE 748
Query: 618 EQSISWLRA-LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVK 658
+Q W +I S + ++QI+FE + G +IAIDD++
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 28/170 (16%)
Query: 19 LDLPAG-SCAFE--ESTCGFDSVLASLPWILN--------------EEGHYIYVDTSFGK 61
L LP+G +C F+ E CG+ + W+ ++ +++ + + +
Sbjct: 638 LQLPSGFNCNFDFLEEPCGW--MYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQR 695
Query: 62 QGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
+G+ A L+SP + C+ YQ T + L + E +LLW +E
Sbjct: 696 EGQYARLISPPVHLPRSPVCMEFQYQATGGRG-------VALQVVREASQESKLLWVIRE 748
Query: 121 PSDS-WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE 169
W + L + +++I+ EGV+G+G + IA+ +I+++T +E
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE 798
Score = 34.7 bits (78), Expect = 0.30
Identities = 56/243 (23%), Positives = 94/243 (38%), Gaps = 23/243 (9%)
Query: 205 PQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAG-CLSFYYQIQQGNDNVFSL 263
P D TF + +++ + S + Q A+LISP P + C+ F YQ G +
Sbjct: 675 PNDRTFPDDR-NFLRLQSDSQREGQ-YARLISPPVHLPRSPVCMEFQYQATGGRGVALQV 732
Query: 264 YTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGPKGGYVALDDIS 321
R+ + + +W W + + Y ME ++FE + G +A+DDI
Sbjct: 733 -VREASQESKLLWVIREDQGGEWKHGRIILPS-YDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Query: 322 FS-PVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAGDHTTGLG 380
S V +N E + + + +E D N G G P+ + L
Sbjct: 791 ISTDVPLENCMEPISAFAD---EYEVDWSNSSSATSGSG------APSTDKEKSWLYTLD 841
Query: 381 YYLLANTKFTSQPGYIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQ 440
L+ +S +G L G + G L YC + + + TL Y FE ++
Sbjct: 842 PILITIIAMSS----LGVLLGATCAGLLLYCTCSYSGLSS--RSCTTLENYNFELYDGLK 895
Query: 441 EKI 443
K+
Sbjct: 896 HKV 898
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/222 (26%), Positives = 94/222 (42%), Gaps = 22/222 (9%)
Query: 449 SPRGVWMQAEIT---FKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLG-SCS--SSEKL 502
SP G+ M+ E+ + PT KS ++ + G +CS + L
Sbjct: 579 SPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDL 638
Query: 503 PPPPG-ECTFE--QDEC--TFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIE 557
P G C F+ ++ C + K R++W +P T P + ++ ++
Sbjct: 639 QLPSGFNCNFDFLEEPCGWMYDHAKWLRTTW--ASSSSPNDRTFPDDRN------FLRLQ 690
Query: 558 ASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
+ GQ ARL+S P+ C+ F Y GG L V +E E LLW R
Sbjct: 691 SDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVV--REASQESKLLWVIRE 748
Query: 618 EQSISWLRA-LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVK 658
+Q W +I S + ++QI+FE + G +IAIDD++
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 28/170 (16%)
Query: 19 LDLPAG-SCAFE--ESTCGFDSVLASLPWILN--------------EEGHYIYVDTSFGK 61
L LP+G +C F+ E CG+ + W+ ++ +++ + + +
Sbjct: 638 LQLPSGFNCNFDFLEEPCGW--MYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQR 695
Query: 62 QGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
+G+ A L+SP + C+ YQ T + L + E +LLW +E
Sbjct: 696 EGQYARLISPPVHLPRSPVCMEFQYQATGGRG-------VALQVVREASQESKLLWVIRE 748
Query: 121 PSDS-WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE 169
W + L + +++I+ EGV+G+G + IA+ +I+++T +E
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE 798
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 205 PQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAG-CLSFYYQIQQGNDNVFSL 263
P D TF + +++ + S + Q A+LISP P + C+ F YQ G +
Sbjct: 675 PNDRTFPDDR-NFLRLQSDSQREGQ-YARLISPPVHLPRSPVCMEFQYQATGGRGVALQV 732
Query: 264 YTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGPKGGYVALDDIS 321
R+ + + +W W + + Y ME ++FE + G +A+DDI
Sbjct: 733 -VREASQESKLLWVIREDQGGEWKHGRIILPS-YDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Query: 322 FS 323
S
Sbjct: 791 IS 792
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/222 (26%), Positives = 94/222 (42%), Gaps = 22/222 (9%)
Query: 449 SPRGVWMQAEIT---FKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLG-SCS--SSEKL 502
SP G+ M+ E+ + PT KS ++ + G +CS + L
Sbjct: 579 SPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDL 638
Query: 503 PPPPG-ECTFE--QDEC--TFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIE 557
P G C F+ ++ C + K R++W +P T P + ++ ++
Sbjct: 639 QLPSGFNCNFDFLEEPCGWMYDHAKWLRTTW--ASSSSPNDRTFPDDRN------FLRLQ 690
Query: 558 ASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
+ GQ ARL+S P+ C+ F Y GG L V +E E LLW R
Sbjct: 691 SDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVV--REASQESKLLWVIRE 748
Query: 618 EQSISWLRA-LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVK 658
+Q W +I S + ++QI+FE + G +IAIDD++
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 28/170 (16%)
Query: 19 LDLPAG-SCAFE--ESTCGFDSVLASLPWILN--------------EEGHYIYVDTSFGK 61
L LP+G +C F+ E CG+ + W+ ++ +++ + + +
Sbjct: 638 LQLPSGFNCNFDFLEEPCGW--MYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQR 695
Query: 62 QGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
+G+ A L+SP + C+ YQ T + L + E +LLW +E
Sbjct: 696 EGQYARLISPPVHLPRSPVCMEFQYQATGGRG-------VALQVVREASQESKLLWVIRE 748
Query: 121 PSDS-WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE 169
W + L + +++I+ EGV+G+G + IA+ +I+++T +E
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE 798
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/157 (25%), Positives = 69/157 (43%), Gaps = 11/157 (7%)
Query: 205 PQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAG-CLSFYYQIQQGNDNVFSL 263
P D TF + +++ + S + Q A+LISP P + C+ F YQ G +
Sbjct: 675 PNDRTFPDDR-NFLRLQSDSQREGQ-YARLISPPVHLPRSPVCMEFQYQATGGRGVALQV 732
Query: 264 YTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGPKGGYVALDDIS 321
R+ + + +W W + + Y ME ++FE + G +A+DDI
Sbjct: 733 -VREASQESKLLWVIREDQGGEWKHGRIILPS-YDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Query: 322 FS-PVHCQNQTELLFSAVEASCNFEQDLCNFYQDKEG 357
S V +N E + + A NF+ D+ + ++EG
Sbjct: 791 ISTDVPLENCMEPI--SAFAGENFKVDIPEIH-EREG 824
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 55.1 bits (131), Expect = 2e-07
Identities = 58/222 (26%), Positives = 94/222 (42%), Gaps = 22/222 (9%)
Query: 449 SPRGVWMQAEIT---FKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLG-SCS--SSEKL 502
SP G+ M+ E+ + PT KS ++ + G +CS + L
Sbjct: 579 SPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDL 638
Query: 503 PPPPG-ECTFE--QDEC--TFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIE 557
P G C F+ ++ C + K R++W +P T P + ++ ++
Sbjct: 639 QLPSGFNCNFDFLEEPCGWMYDHAKWLRTTW--ASSSSPNDRTFPDDRN------FLRLQ 690
Query: 558 ASHMVYGQKARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
+ GQ ARL+S P+ C+ F Y GG L V +E E LLW R
Sbjct: 691 SDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVV--REASQESKLLWVIRE 748
Query: 618 EQSISWLRA-LIEYSCERQHQIIFEAIRGVSIRSDIAIDDVK 658
+Q W +I S + ++QI+FE + G +IAIDD++
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 28/170 (16%)
Query: 19 LDLPAG-SCAFE--ESTCGFDSVLASLPWILN--------------EEGHYIYVDTSFGK 61
L LP+G +C F+ E CG+ + W+ ++ +++ + + +
Sbjct: 638 LQLPSGFNCNFDFLEEPCGW--MYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQR 695
Query: 62 QGEKAVLLSPDLQAEEWS-CLRLVYQITTSSESLSDPSQLNLYMRFEDESFDRLLWSAKE 120
+G+ A L+SP + C+ YQ T + L + E +LLW +E
Sbjct: 696 EGQYARLISPPVHLPRSPVCMEFQYQATGGRG-------VALQVVREASQESKLLWVIRE 748
Query: 121 PSDS-WLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKMTTGYCIE 169
W + L + +++I+ EGV+G+G + IA+ +I+++T +E
Sbjct: 749 DQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLE 798
Score = 33.9 bits (76), Expect = 0.51
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 205 PQDHTFKSELGHYMYVDSVYVKHFQEVAQLISPLTTAPMAG-CLSFYYQIQQGNDNVFSL 263
P D TF + +++ + S + Q A+LISP P + C+ F YQ G +
Sbjct: 675 PNDRTFPDDR-NFLRLQSDSQREGQ-YARLISPPVHLPRSPVCMEFQYQATGGRGVALQV 732
Query: 264 YTRDVAGLYEEIWKADRPGNAAWNLAEVEFSAPYPME--VIFEVAFNGPKGGYVALDDIS 321
R+ + + +W W + + Y ME ++FE + G +A+DDI
Sbjct: 733 -VREASQESKLLWVIREDQGGEWKHGRIILPS-YDMEYQIVFEGVIGKGRSGEIAIDDIR 790
Query: 322 FS 323
S
Sbjct: 791 IS 792
>gi|13124888 epidermal growth factor-like protein 6 precursor [Homo
sapiens]
Length = 553
Score = 54.7 bits (130), Expect = 3e-07
Identities = 42/161 (26%), Positives = 67/161 (41%), Gaps = 21/161 (13%)
Query: 508 ECTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEA--SHMVYGQ 565
+C+F C + Q++ + W+ D +G+YM + A H
Sbjct: 401 DCSFNHGICDWKQDREDDFDWN-------------PADRDNAIGFYMAVPALAGHKKDIG 447
Query: 566 KARLLSRPLRGVSGKHCLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLR 625
+ +LL L+ S CL F Y + G G L V++K +S +L W + + W
Sbjct: 448 RLKLLLPDLQPQSN-FCLLFDYRLAGDKVGKLRVFVK---NSNNALAWEKTTSEDEKWKT 503
Query: 626 ALIEY--SCERQHQIIFEAIRGVSIRSDIAIDDVKFQAGPC 664
I+ + IIFEA RG +IA+D V +G C
Sbjct: 504 GKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLVSGLC 544
Score = 37.0 bits (84), Expect = 0.061
Identities = 37/166 (22%), Positives = 61/166 (36%), Gaps = 20/166 (12%)
Query: 338 VEASCNFEQDLCNFYQDKEGP-GWTRVKVKPNMYRAGDHTTGLGYYLLANTKFTSQPGYI 396
+ C+F +C++ QD+E W D +G+Y +A I
Sbjct: 398 ISVDCSFNHGICDWKQDREDDFDW----------NPADRDNAIGFY-MAVPALAGHKKDI 446
Query: 397 GR--LYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVW 454
GR L P L +CL F Y + G L V++ N+ + W S W
Sbjct: 447 GRLKLLLPDLQPQSNFCLLFDYRLAG--DKVGKLRVFVKNSNNAL---AWEKTTSEDEKW 501
Query: 455 MQAEI-TFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGSCSSS 499
+I ++ TK + + G +A+D + + G C S
Sbjct: 502 KTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLVSGLCPDS 547
Score = 34.7 bits (78), Expect = 0.30
Identities = 31/125 (24%), Positives = 52/125 (41%), Gaps = 12/125 (9%)
Query: 47 NEEGHYIYVDTSFGKQGE--KAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYM 104
N G Y+ V G + + + LL PDLQ + CL Y++ +L +++
Sbjct: 428 NAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVG-----KLRVFV 482
Query: 105 RFEDESFDRLLWSAKEPSDS-WLIASLDLQNSSKKFK-ILIEGVLGQGNTASIALFEIKM 162
+ S + L W D W + L + K I+ E G+G T IA+ + +
Sbjct: 483 K---NSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLL 539
Query: 163 TTGYC 167
+G C
Sbjct: 540 VSGLC 544
>gi|239755252 PREDICTED: hypothetical protein [Homo sapiens]
Length = 377
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/157 (27%), Positives = 66/157 (42%), Gaps = 6/157 (3%)
Query: 509 CTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYGQKAR 568
C FE C TQ++ + SW +R G S P DH V + ++ V +
Sbjct: 69 CDFEDGLCHMTQDQSLQPSWTKRSGMIGLS--PPFYDHNGDVSAH-FLSLVSRVDSISSS 125
Query: 569 LLSRPLRGVSGKH-CLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRAL 627
L SR + +H C FY+ +G L V L+ LW+ W R +
Sbjct: 126 LRSRVFLPTNDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQWERNV 185
Query: 628 IEYSCERQHQIIFEAIRGVSIRSD--IAIDDVKFQAG 662
I+ ++ Q++FE + D IAIDD+ F +G
Sbjct: 186 IKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSG 222
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/292 (21%), Positives = 114/292 (39%), Gaps = 51/292 (17%)
Query: 342 CNFEQDLCNFYQDKE-GPGWTR----VKVKPNMYRAGDHTTGLGYYLLA--NTKFTSQPG 394
C+FE LC+ QD+ P WT+ + + P Y DH + + L+ + +
Sbjct: 69 CDFEDGLCHMTQDQSLQPSWTKRSGMIGLSPPFY---DHNGDVSAHFLSLVSRVDSISSS 125
Query: 395 YIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVW 454
R++ LP N Q+ + + Y ++S L V + + +W + W
Sbjct: 126 LRSRVF---LPTNDQHDCQITF-YYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQW 181
Query: 455 MQAEITFKKPMPTKVVFM-SLCKSFWDCGLVALDDITIQLG-------------SCSSSE 500
+ I + +VVF + ++ ++A+DDI+ G + ++
Sbjct: 182 ERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSGCLPANDGILLCQEALNAER 241
Query: 501 KLPPPPGE----------------CTFEQDECTFTQE-KRNRSSWHRRRG-ETPTSYTGP 542
+L P + C FE D C +T E + SW R + E P + P
Sbjct: 242 ELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWTSEASAGQISWMRTKAREIPAFESTP 301
Query: 543 KGDH-TTGVGYYMYIEASH---MVYGQKARLLSRPLRGVSGKHC-LTFFYHM 589
+ D GYY+++ A H + + L+ + GK C L F+Y M
Sbjct: 302 QQDQGGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCLGKSCHLQFYYAM 353
Score = 32.3 bits (72), Expect = 1.5
Identities = 57/264 (21%), Positives = 93/264 (35%), Gaps = 58/264 (21%)
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELG-HYMY----VDSVY 224
CDFE+ LC + +W G I + P + ++ H++ VDS+
Sbjct: 69 CDFEDG-LCHMTQDQSLQPSWTKRSGMI----GLSPPFYDHNGDVSAHFLSLVSRVDSIS 123
Query: 225 VKHFQEVAQLISPLTTAPMAGC-LSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGN 283
V L T C ++FYY Q + + G + +W+
Sbjct: 124 SSLRSRVF-----LPTNDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALP 178
Query: 284 AAWNLAEVEFSAPYPMEVIFE--VAFNGPKGGYVALDDISFS----PVH----------- 326
W ++ + +V+FE +A + +A+DDISFS P +
Sbjct: 179 NQWERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSGCLPANDGILLCQEALN 238
Query: 327 -----CQNQTELL-FSAVE------ASCNFEQDLCNFYQDKEGP--GWTRVKVK------ 366
C T+L F A + +C FE D+C + + W R K +
Sbjct: 239 AERELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWTSEASAGQISWMRTKAREIPAFE 298
Query: 367 --PNMYRAGDHTTGLGYYLLANTK 388
P + GD GYY+ K
Sbjct: 299 STPQQDQGGDDE---GYYVWVGAK 319
>gi|169201936 PREDICTED: hypothetical protein [Homo sapiens]
Length = 377
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/157 (27%), Positives = 66/157 (42%), Gaps = 6/157 (3%)
Query: 509 CTFEQDECTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVGYYMYIEASHMVYGQKAR 568
C FE C TQ++ + SW +R G S P DH V + ++ V +
Sbjct: 69 CDFEDGLCHMTQDQSLQPSWTKRSGMIGLS--PPFYDHNGDVSAH-FLSLVSRVDSISSS 125
Query: 569 LLSRPLRGVSGKH-CLTFFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRAL 627
L SR + +H C FY+ +G L V L+ LW+ W R +
Sbjct: 126 LRSRVFLPTNDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQWERNV 185
Query: 628 IEYSCERQHQIIFEAIRGVSIRSD--IAIDDVKFQAG 662
I+ ++ Q++FE + D IAIDD+ F +G
Sbjct: 186 IKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSG 222
Score = 39.7 bits (91), Expect = 0.009
Identities = 64/292 (21%), Positives = 114/292 (39%), Gaps = 51/292 (17%)
Query: 342 CNFEQDLCNFYQDKE-GPGWTR----VKVKPNMYRAGDHTTGLGYYLLA--NTKFTSQPG 394
C+FE LC+ QD+ P WT+ + + P Y DH + + L+ + +
Sbjct: 69 CDFEDGLCHMTQDQSLQPSWTKRSGMIGLSPPFY---DHNGDVSAHFLSLVSRVDSISSS 125
Query: 395 YIGRLYGPSLPGNLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVW 454
R++ LP N Q+ + + Y ++S L V + + +W + W
Sbjct: 126 LRSRVF---LPTNDQHDCQITF-YYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALPNQW 181
Query: 455 MQAEITFKKPMPTKVVFM-SLCKSFWDCGLVALDDITIQLG-------------SCSSSE 500
+ I + +VVF + ++ ++A+DDI+ G + ++
Sbjct: 182 ERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSGCLPANDGILLCQEALNAER 241
Query: 501 KLPPPPGE----------------CTFEQDECTFTQE-KRNRSSWHRRRG-ETPTSYTGP 542
+L P + C FE D C +T E + SW R + E P + P
Sbjct: 242 ELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWTSEASAGQISWMRTKAREIPAFESTP 301
Query: 543 KGDH-TTGVGYYMYIEASH---MVYGQKARLLSRPLRGVSGKHC-LTFFYHM 589
+ D GYY+++ A H + + L+ + GK C L F+Y M
Sbjct: 302 QQDQGGDDEGYYVWVGAKHGFTLNHLDSRAYLNSSVCHCLGKSCHLQFYYAM 353
Score = 32.3 bits (72), Expect = 1.5
Identities = 57/264 (21%), Positives = 93/264 (35%), Gaps = 58/264 (21%)
Query: 170 CDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELG-HYMY----VDSVY 224
CDFE+ LC + +W G I + P + ++ H++ VDS+
Sbjct: 69 CDFEDG-LCHMTQDQSLQPSWTKRSGMI----GLSPPFYDHNGDVSAHFLSLVSRVDSIS 123
Query: 225 VKHFQEVAQLISPLTTAPMAGC-LSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGN 283
V L T C ++FYY Q + + G + +W+
Sbjct: 124 SSLRSRVF-----LPTNDQHDCQITFYYFSCQVSGKLMVGLQTACGGPIQHLWQNTAALP 178
Query: 284 AAWNLAEVEFSAPYPMEVIFE--VAFNGPKGGYVALDDISFS----PVH----------- 326
W ++ + +V+FE +A + +A+DDISFS P +
Sbjct: 179 NQWERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAIDDISFSSGCLPANDGILLCQEALN 238
Query: 327 -----CQNQTELL-FSAVE------ASCNFEQDLCNFYQDKEGP--GWTRVKVK------ 366
C T+L F A + +C FE D+C + + W R K +
Sbjct: 239 AERELCHPDTDLCRFDATDEELRLCQACGFEFDMCEWTSEASAGQISWMRTKAREIPAFE 298
Query: 367 --PNMYRAGDHTTGLGYYLLANTK 388
P + GD GYY+ K
Sbjct: 299 STPQQDQGGDDE---GYYVWVGAK 319
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,814,216
Number of Sequences: 37866
Number of extensions: 1363985
Number of successful extensions: 3030
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2718
Number of HSP's gapped (non-prelim): 170
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.