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Search of human proteins with 22208951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 907 0.0
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 907 0.0
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 159 5e-39
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 154 2e-37
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 139 5e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 130 2e-30
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 130 2e-30
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 130 2e-30
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 130 2e-30
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 130 2e-30
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 127 2e-29
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 127 2e-29
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 127 2e-29
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 122 9e-28
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 112 7e-25
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 110 2e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 110 2e-24
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 109 6e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 109 6e-24
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 107 2e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 106 5e-23
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 105 1e-22
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 105 1e-22
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 103 3e-22
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 102 7e-22
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 102 7e-22
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 100 3e-21
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 100 3e-21
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 98 1e-20
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 98 1e-20
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 907 bits (2344), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ
Sbjct: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE
Sbjct: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA
Sbjct: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV
Sbjct: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 300
FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP
Sbjct: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 300
Query: 301 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 360
WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT
Sbjct: 301 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 360
Query: 361 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 420
LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS
Sbjct: 361 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 420
Query: 421 LHNYLLYEDVLRMYEVPELAAIQDG 445
LHNYLLYEDVLRMYEVPELAAIQDG
Sbjct: 421 LHNYLLYEDVLRMYEVPELAAIQDG 445
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 907 bits (2344), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ
Sbjct: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE
Sbjct: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA
Sbjct: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV
Sbjct: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 300
FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP
Sbjct: 314 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 373
Query: 301 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 360
WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT
Sbjct: 374 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 433
Query: 361 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 420
LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS
Sbjct: 434 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 493
Query: 421 LHNYLLYEDVLRMYEVPELAAIQDG 445
LHNYLLYEDVLRMYEVPELAAIQDG
Sbjct: 494 LHNYLLYEDVLRMYEVPELAAIQDG 518
Score = 68.9 bits (167), Expect = 9e-12
Identities = 56/199 (28%), Positives = 107/199 (53%), Gaps = 15/199 (7%)
Query: 80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN---CQA 136
A+ + N ++++ LL+KG + + D+ G P+ AA + +E L +LI++ ++ N +
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196
+ L +AA +GH K V++LL +GADP+ E++ P+ A + G +L LL L
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLL--L 132
Query: 197 TNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQK 253
+ A G + + + ++ A F + + +++LLR G + + Q FG +P+ +A Q
Sbjct: 133 QHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD--DFGI-TPLFVAAQY 189
Query: 254 DCEFFGIVNILLKYGAQIN 272
++IL+ GA +N
Sbjct: 190 G--KLESLSILISSGANVN 206
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 159 bits (402), Expect = 5e-39
Identities = 131/480 (27%), Positives = 225/480 (46%), Gaps = 61/480 (12%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT +G L LA G + V+ LLE G PN + TPL +AV+ G D++ L++H
Sbjct: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
+++ + W+++H+A+ Q +I+ LLL+ G N +D FG+TPL VAA+YG +
Sbjct: 167 NTSLD-QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDV 225
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
L LI G +V A D A+ LF AA G+ C+ LLL G ++ + LPIH A
Sbjct: 226 LEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV--PNRAGHLPIHRA 283
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG----------- 230
A GH L LIP+T++ + ++P++SA G + CLE+L+ NG
Sbjct: 284 AYEGHYLALKYLIPVTSKNA-IRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHI 342
Query: 231 ---YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGIVNILLKY 267
Y + + L FG S+ P+ C+ + IV +LL +
Sbjct: 343 SQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSH 402
Query: 268 GAQIN--ELH---------LAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQA 316
GA +N +H + Y L E + R L G + ++ ++ I +
Sbjct: 403 GANVNCYFMHVNDTRFPSVIQYALNDE--VMLRLLLNNGYQV---EMCFDCMHGDIFGNS 457
Query: 317 KYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTL-----IFTLEFTNWKTLAPAVERMLSA 371
+ ++ G+ ++ N + + +++ + T ++ P ++ SA
Sbjct: 458 FVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSA 517
Query: 372 -RASNAW-ILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
W ++Q + SL HLCRL+IR + ++L + + +LPLP ++ Y+L+++
Sbjct: 518 LEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 577
Score = 60.1 bits (144), Expect = 4e-09
Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 38/222 (17%)
Query: 46 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKL-------------- 91
A++ G I L+ +++ ++ + GW LH+A Q +I+++
Sbjct: 50 AIKQGHIPELQEYVKYKYAMDEADEK-GWFPLHEAVVQPIQQILEIVLDASYKTLWEFKT 108
Query: 92 ---------------------LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGA 130
LL KG ++D G TPL +A + G + +S LI
Sbjct: 109 CDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
Query: 131 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 190
+++ + + + + AA++G V LLL G +++ + P+ AA+ GH +L
Sbjct: 169 SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGG--NVHLRDGFGVTPLGVAAEYGHCDVL 226
Query: 191 DLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYS 232
+ LI + S ++ A GG+ DC+ +LL G S
Sbjct: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGS 268
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 154 bits (389), Expect = 2e-37
Identities = 127/485 (26%), Positives = 227/485 (46%), Gaps = 76/485 (15%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T + A++LA +GH + LL+AGA+P+ + TPL+ A E + +++L+QH
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A+ N + GW +LH++ + + E++++L+ GA E ++ +GITPLFVAAQ G+LE+
Sbjct: 180 NADTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
L L GA++N QA D A+ L+ A + H + VE LLS GAD + N+D LP+H A
Sbjct: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK-TNKDGL-LPLHIA 296
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLE----------------- 224
++ G+ +I+ +L+P+T+R + VSP++ A H++ LE
Sbjct: 297 SKKGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 355
Query: 225 -------------------------ILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFG 259
+LL++G P+ SP+ +A + C
Sbjct: 356 ARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI------SPLLVAIRHGC--LR 407
Query: 260 IVNILLKYGAQINELHLAYCLKYEK--------FSIFRYFLRKGCSLGP-WNHIYEFVNH 310
+ +LL +GA I+ + + S+ ++ + GC P ++ +Y H
Sbjct: 408 TMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPH 467
Query: 311 AIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDT-----LIFTLEFTNWKTLAPAV 365
Q + A +P ++ ++ + + + L++ L +
Sbjct: 468 PPAPQPSSR--FNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRL 525
Query: 366 ERMLSARASNAWILQQHIATVPS-LTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNY 424
+ + + W + + A P L HLCRL +R ++ R++ + LPLP L Y
Sbjct: 526 KEHIDSFED--WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRY 580
Query: 425 LLYED 429
L YE+
Sbjct: 581 LKYEN 585
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 37 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 96
L PL A+++G + L+ +++ G N+ + GW LH+A++ +K+L R
Sbjct: 55 LAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
Query: 97 A----NKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 152
+ Q++ T +++A G L+ L L+ +GA + + TPL+ A + +
Sbjct: 114 PGTIDQRTLQEE---TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
Query: 153 KCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 212
+ V++L+ AD + CN W +H + +++ +L+ + ++P++
Sbjct: 171 EAVKILVQHNADTNHRCNR-GW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 213 SAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC--EFFGIVNILLKYGAQ 270
A G + L L + G + QA S A + C E +V LL GA
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQA-------SDNASALYEACKNEHEEVVEFLLSQGAD 281
Query: 271 INE 273
N+
Sbjct: 282 ANK 284
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 139 bits (350), Expect = 5e-33
Identities = 125/419 (29%), Positives = 194/419 (46%), Gaps = 58/419 (13%)
Query: 57 LLLQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 114
LL+ +GA+VN C +LH+A+ +++KL+L GA+ + Q +G TPL +AA
Sbjct: 4 LLINYGADVN---LRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
Query: 115 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 174
Q G E + +L+ GAN + QA D ++ L AA G+ V LLL GAD ++ N S
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN--SG 118
Query: 175 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---- 230
LPIH AA GH L +LIP+T+ A + +SPV+ A G H CLE+L++ G
Sbjct: 119 HLPIHVAADRGHLLALKILIPVTDLAA-IKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
Query: 231 ----------YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGI 260
Y ++ L F S+ PV C+ + +
Sbjct: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYEL 237
Query: 261 VNILLKYGA------QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 314
+++LL++GA ++N LH L+Y LR + G H K
Sbjct: 238 ISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKV 295
Query: 315 QAKY--KEWLPHLLV-AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSA 371
Y + W ++ F +I L SW+ +S + L++ + + ++ +L
Sbjct: 296 HPSYTVEGWTSTVIKDTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQK 353
Query: 372 RASNAWILQQHIATVP-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
+ W I T P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 354 QG--IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 410
Score = 69.3 bits (168), Expect = 7e-12
Identities = 72/246 (29%), Positives = 122/246 (49%), Gaps = 24/246 (9%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
GF L LAA GH +I+++LL GA+ + + ++ L A G D + LLL++GA+
Sbjct: 52 GFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADA 111
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + G +H A+ + + +K+L+ + GI+P+ AA + L +L
Sbjct: 112 NIPKN-SGHLPIHVAADRGHLLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELL 169
Query: 126 ISSGANVNC---QALDK------ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQL 176
I +G +VN Q ++K + L+ A V+LLLS+GA P N+D
Sbjct: 170 IQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP----NQDPVNC 225
Query: 177 PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY--SAVFGGHED--CLEILLRNGYS 232
+ A +MG+ +++ LL L + A +V+P++ SA+ +D L +LL GY
Sbjct: 226 -LQIALRMGNYELISLL--LRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGY- 281
Query: 233 PDAQAC 238
D + C
Sbjct: 282 -DTERC 286
Score = 57.0 bits (136), Expect = 3e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
++LI+ GA+VN + ++ T L AA+ G V+L+L SGA PD P+ AA
Sbjct: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGF--TPLALAA 60
Query: 183 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
Q GHT+I+++L+ A + S + A GG+ D + +LL G
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG 108
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 130 bits (328), Expect = 2e-30
Identities = 93/301 (30%), Positives = 145/301 (48%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+ LLL+ G
Sbjct: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+++ + G LH ASF + I+K LL++GA+ + TPL +AA+ G E
Sbjct: 428 ASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL--------------- 167
L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 546
Query: 168 ----------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
C P+H AA+ G ++ +LL+ G N ++P+
Sbjct: 547 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 606
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ AV + D +++LL G SP + A G++ A Q E + LL+YG
Sbjct: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSLLQYGGSA 661
Query: 272 N 272
N
Sbjct: 662 N 662
Score = 128 bits (322), Expect = 9e-30
Identities = 103/358 (28%), Positives = 172/358 (48%), Gaps = 46/358 (12%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G +V+ L+ +G
Sbjct: 143 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 202
Query: 65 ----VNGSH------------------------SMCGWNSLHQASFQENAEIIKLLLRKG 96
+ H S G+ LH A+ EN + +LLL +G
Sbjct: 203 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 262
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ GITPL +A++ G + + +L+ GA + + D+ TPL AA+ GH + E
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
+LL GA + + PIH AAQ H + LL+ D L+ ++P++ A
Sbjct: 323 ILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---- 272
GH ++LL G P+++A F +P+ +A +K+ ++ +LLK GA I+
Sbjct: 381 CGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVMELLLKTGASIDAVTE 435
Query: 273 ----ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLL 326
LH+A + + I + L++G S N E H + A+A + E +LL
Sbjct: 436 SGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAARAGHTEVAKYLL 490
Score = 127 bits (320), Expect = 2e-29
Identities = 94/274 (34%), Positives = 139/274 (50%), Gaps = 8/274 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 591 RDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 649
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H
Sbjct: 650 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHL 707
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AQ GH + D+LI T +P++ A G+ ++ LL+ + D A
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTK 765
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 274
G+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 766 LGY-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 796
Score = 118 bits (295), Expect = 1e-26
Identities = 94/351 (26%), Positives = 157/351 (44%), Gaps = 52/351 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V++ LL++G
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 167
Query: 63 ANVN----------------------------GSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N G+ +LH A+ ++ +LL+
Sbjct: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 227
Query: 95 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC 154
N + G TPL +AA Y L +L++ GA+VN + TPL IA++ G+
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 287
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
V LLL GA + ++ P+H AA+ GH +I ++L+ N +SP++ A
Sbjct: 288 VRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE- 273
G H DC+ +LL+ D + +P+ +A C + +LL GA+ N
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLDKGAKPNSR 400
Query: 274 -------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 310
LH+A K + L+ G S+ H+ F+ H
Sbjct: 401 ALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449
Score = 114 bits (286), Expect = 1e-25
Identities = 70/233 (30%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT + LH AA GH +I +ILL+ GA A T +P+ +A + +D +RLLLQ+
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 360
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A ++ ++ LH A+ + + K+LL KGA + G TPL +A + +
Sbjct: 361 DAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ +GA+++ TPL +A+ GH V+ LL GA P++ + + P+H A
Sbjct: 420 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMA 477
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
A+ GHT++ L+ + + +P++ A GH + +++LL N +P+
Sbjct: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Score = 106 bits (265), Expect = 4e-23
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 37/300 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA+ +GH K+V LL TT + T L +A GQ +V+R L+ +GANV
Sbjct: 78 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GAN+ + G TPL VA Q G ++ L
Sbjct: 138 N-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Query: 126 ISSGA---------------------------NVNCQALDKA--TPLFIAAQEGHTKCVE 156
I+ G + N L K TPL IAA + +
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 256
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
LLL+ GA + + P+H A++ G+ ++ LL+ + ++++P++ A
Sbjct: 257 LLLNRGASVNF--TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 314
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 276
GH EILL +G QA G SP+ MA Q D V +LL+Y A+I+++ L
Sbjct: 315 NGHVRISEILLDHG--APIQAKTKNGL-SPIHMAAQGD--HLDCVRLLLQYDAEIDDITL 369
Score = 106 bits (264), Expect = 5e-23
Identities = 63/196 (32%), Positives = 108/196 (55%), Gaps = 5/196 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL A
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 64 NVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
N N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++ +
Sbjct: 693 NGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAK 808
Query: 183 QMGHTKILDLLIPLTN 198
++G+ + D+L +T+
Sbjct: 809 RLGYISVTDVLKVVTD 824
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT G+ LH AA QGH IV +LL+ GA PN + + TTPL +A G I V +L
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--- 819
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEII 89
V S + H+ SF E + I
Sbjct: 820 -KVVTDETSFVLVSDKHRMSFPETVDEI 846
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 11/174 (6%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T AA+ G L+ + +G ++N + L +A++EGH K V LL + L
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIIL 104
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+H AA G +++ L+ +P+Y A H + ++ LL
Sbjct: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG----AQINELHLA 277
NG + GF +P+ +A Q+ E +V L+ YG ++ LH+A
Sbjct: 165 ENG--ANQNVATEDGF-TPLAVALQQGHE--NVVAHLINYGTKGKVRLPALHIA 213
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 130 bits (328), Expect = 2e-30
Identities = 93/301 (30%), Positives = 145/301 (48%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+ LLL+ G
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+++ + G LH ASF + I+K LL++GA+ + TPL +AA+ G E
Sbjct: 395 ASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL--------------- 167
L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
Query: 168 ----------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
C P+H AA+ G ++ +LL+ G N ++P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ AV + D +++LL G SP + A G++ A Q E + LL+YG
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSLLQYGGSA 628
Query: 272 N 272
N
Sbjct: 629 N 629
Score = 128 bits (322), Expect = 9e-30
Identities = 103/358 (28%), Positives = 172/358 (48%), Gaps = 46/358 (12%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G +V+ L+ +G
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 65 ----VNGSH------------------------SMCGWNSLHQASFQENAEIIKLLLRKG 96
+ H S G+ LH A+ EN + +LLL +G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ GITPL +A++ G + + +L+ GA + + D+ TPL AA+ GH + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
+LL GA + + PIH AAQ H + LL+ D L+ ++P++ A
Sbjct: 290 ILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---- 272
GH ++LL G P+++A F +P+ +A +K+ ++ +LLK GA I+
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVMELLLKTGASIDAVTE 402
Query: 273 ----ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLL 326
LH+A + + I + L++G S N E H + A+A + E +LL
Sbjct: 403 SGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAARAGHTEVAKYLL 457
Score = 127 bits (320), Expect = 2e-29
Identities = 94/274 (34%), Positives = 139/274 (50%), Gaps = 8/274 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 558 RDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHL 674
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AQ GH + D+LI T +P++ A G+ ++ LL+ + D A
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTK 732
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 274
G+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 733 LGY-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 118 bits (295), Expect = 1e-26
Identities = 94/351 (26%), Positives = 157/351 (44%), Gaps = 52/351 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V++ LL++G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 63 ANVN----------------------------GSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N G+ +LH A+ ++ +LL+
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 95 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC 154
N + G TPL +AA Y L +L++ GA+VN + TPL IA++ G+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
V LLL GA + ++ P+H AA+ GH +I ++L+ N +SP++ A
Sbjct: 255 VRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE- 273
G H DC+ +LL+ D + +P+ +A C + +LL GA+ N
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLDKGAKPNSR 367
Query: 274 -------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 310
LH+A K + L+ G S+ H+ F+ H
Sbjct: 368 ALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 114 bits (286), Expect = 1e-25
Identities = 70/233 (30%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT + LH AA GH +I +ILL+ GA A T +P+ +A + +D +RLLLQ+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A ++ ++ LH A+ + + K+LL KGA + G TPL +A + +
Sbjct: 328 DAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ +GA+++ TPL +A+ GH V+ LL GA P++ + + P+H A
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMA 444
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
A+ GHT++ L+ + + +P++ A GH + +++LL N +P+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 106 bits (265), Expect = 4e-23
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 37/300 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA+ +GH K+V LL TT + T L +A GQ +V+R L+ +GANV
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GAN+ + G TPL VA Q G ++ L
Sbjct: 105 N-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 126 ISSGA---------------------------NVNCQALDKA--TPLFIAAQEGHTKCVE 156
I+ G + N L K TPL IAA + +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
LLL+ GA + + P+H A++ G+ ++ LL+ + ++++P++ A
Sbjct: 224 LLLNRGASVNF--TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 276
GH EILL +G QA G SP+ MA Q D V +LL+Y A+I+++ L
Sbjct: 282 NGHVRISEILLDHG--APIQAKTKNGL-SPIHMAAQGD--HLDCVRLLLQYDAEIDDITL 336
Score = 106 bits (264), Expect = 5e-23
Identities = 63/196 (32%), Positives = 108/196 (55%), Gaps = 5/196 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 64 NVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
N N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++ +
Sbjct: 660 NGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAK 775
Query: 183 QMGHTKILDLLIPLTN 198
++G+ + D+L +T+
Sbjct: 776 RLGYISVTDVLKVVTD 791
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT G+ LH AA QGH IV +LL+ GA PN + + TTPL +A G I V +L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--- 786
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEII 89
V S + H+ SF E + I
Sbjct: 787 -KVVTDETSFVLVSDKHRMSFPETVDEI 813
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 11/174 (6%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T AA+ G L+ + +G ++N + L +A++EGH K V LL + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIIL 71
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+H AA G +++ L+ +P+Y A H + ++ LL
Sbjct: 72 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG----AQINELHLA 277
NG + GF +P+ +A Q+ E +V L+ YG ++ LH+A
Sbjct: 132 ENG--ANQNVATEDGF-TPLAVALQQGHE--NVVAHLINYGTKGKVRLPALHIA 180
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 130 bits (328), Expect = 2e-30
Identities = 93/301 (30%), Positives = 145/301 (48%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+ LLL+ G
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+++ + G LH ASF + I+K LL++GA+ + TPL +AA+ G E
Sbjct: 395 ASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL--------------- 167
L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
Query: 168 ----------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
C P+H AA+ G ++ +LL+ G N ++P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ AV + D +++LL G SP + A G++ A Q E + LL+YG
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSLLQYGGSA 628
Query: 272 N 272
N
Sbjct: 629 N 629
Score = 128 bits (322), Expect = 9e-30
Identities = 103/358 (28%), Positives = 172/358 (48%), Gaps = 46/358 (12%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G +V+ L+ +G
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 65 ----VNGSH------------------------SMCGWNSLHQASFQENAEIIKLLLRKG 96
+ H S G+ LH A+ EN + +LLL +G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ GITPL +A++ G + + +L+ GA + + D+ TPL AA+ GH + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
+LL GA + + PIH AAQ H + LL+ D L+ ++P++ A
Sbjct: 290 ILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---- 272
GH ++LL G P+++A F +P+ +A +K+ ++ +LLK GA I+
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVMELLLKTGASIDAVTE 402
Query: 273 ----ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLL 326
LH+A + + I + L++G S N E H + A+A + E +LL
Sbjct: 403 SGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAARAGHTEVAKYLL 457
Score = 127 bits (320), Expect = 2e-29
Identities = 94/274 (34%), Positives = 139/274 (50%), Gaps = 8/274 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 558 RDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHL 674
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AQ GH + D+LI T +P++ A G+ ++ LL+ + D A
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTK 732
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 274
G+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 733 LGY-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 118 bits (295), Expect = 1e-26
Identities = 94/351 (26%), Positives = 157/351 (44%), Gaps = 52/351 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V++ LL++G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 63 ANVN----------------------------GSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N G+ +LH A+ ++ +LL+
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 95 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC 154
N + G TPL +AA Y L +L++ GA+VN + TPL IA++ G+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
V LLL GA + ++ P+H AA+ GH +I ++L+ N +SP++ A
Sbjct: 255 VRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE- 273
G H DC+ +LL+ D + +P+ +A C + +LL GA+ N
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLDKGAKPNSR 367
Query: 274 -------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 310
LH+A K + L+ G S+ H+ F+ H
Sbjct: 368 ALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 114 bits (286), Expect = 1e-25
Identities = 70/233 (30%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT + LH AA GH +I +ILL+ GA A T +P+ +A + +D +RLLLQ+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A ++ ++ LH A+ + + K+LL KGA + G TPL +A + +
Sbjct: 328 DAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ +GA+++ TPL +A+ GH V+ LL GA P++ + + P+H A
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMA 444
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
A+ GHT++ L+ + + +P++ A GH + +++LL N +P+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 106 bits (265), Expect = 4e-23
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 37/300 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA+ +GH K+V LL TT + T L +A GQ +V+R L+ +GANV
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GAN+ + G TPL VA Q G ++ L
Sbjct: 105 N-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 126 ISSGA---------------------------NVNCQALDKA--TPLFIAAQEGHTKCVE 156
I+ G + N L K TPL IAA + +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
LLL+ GA + + P+H A++ G+ ++ LL+ + ++++P++ A
Sbjct: 224 LLLNRGASVNF--TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 276
GH EILL +G QA G SP+ MA Q D V +LL+Y A+I+++ L
Sbjct: 282 NGHVRISEILLDHG--APIQAKTKNGL-SPIHMAAQGD--HLDCVRLLLQYDAEIDDITL 336
Score = 106 bits (264), Expect = 5e-23
Identities = 63/196 (32%), Positives = 108/196 (55%), Gaps = 5/196 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 64 NVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
N N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++ +
Sbjct: 660 NGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAK 775
Query: 183 QMGHTKILDLLIPLTN 198
++G+ + D+L +T+
Sbjct: 776 RLGYISVTDVLKVVTD 791
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT G+ LH AA QGH IV +LL+ GA PN + + TTPL +A G I V +L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--- 786
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEII 89
V S + H+ SF E + I
Sbjct: 787 -KVVTDETSFVLVSDKHRMSFPETVDEI 813
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 11/174 (6%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T AA+ G L+ + +G ++N + L +A++EGH K V LL + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIIL 71
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+H AA G +++ L+ +P+Y A H + ++ LL
Sbjct: 72 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG----AQINELHLA 277
NG + GF +P+ +A Q+ E +V L+ YG ++ LH+A
Sbjct: 132 ENG--ANQNVATEDGF-TPLAVALQQGHE--NVVAHLINYGTKGKVRLPALHIA 180
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 130 bits (328), Expect = 2e-30
Identities = 93/301 (30%), Positives = 145/301 (48%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+ LLL+ G
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+++ + G LH ASF + I+K LL++GA+ + TPL +AA+ G E
Sbjct: 395 ASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL--------------- 167
L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
Query: 168 ----------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
C P+H AA+ G ++ +LL+ G N ++P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ AV + D +++LL G SP + A G++ A Q E + LL+YG
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSLLQYGGSA 628
Query: 272 N 272
N
Sbjct: 629 N 629
Score = 128 bits (322), Expect = 9e-30
Identities = 103/358 (28%), Positives = 172/358 (48%), Gaps = 46/358 (12%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G +V+ L+ +G
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 65 ----VNGSH------------------------SMCGWNSLHQASFQENAEIIKLLLRKG 96
+ H S G+ LH A+ EN + +LLL +G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ GITPL +A++ G + + +L+ GA + + D+ TPL AA+ GH + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
+LL GA + + PIH AAQ H + LL+ D L+ ++P++ A
Sbjct: 290 ILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---- 272
GH ++LL G P+++A F +P+ +A +K+ ++ +LLK GA I+
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVMELLLKTGASIDAVTE 402
Query: 273 ----ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLL 326
LH+A + + I + L++G S N E H + A+A + E +LL
Sbjct: 403 SGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAARAGHTEVAKYLL 457
Score = 127 bits (320), Expect = 2e-29
Identities = 94/274 (34%), Positives = 139/274 (50%), Gaps = 8/274 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 558 RDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHL 674
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AQ GH + D+LI T +P++ A G+ ++ LL+ + D A
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTK 732
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 274
G+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 733 LGY-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 118 bits (295), Expect = 1e-26
Identities = 94/351 (26%), Positives = 157/351 (44%), Gaps = 52/351 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V++ LL++G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 63 ANVN----------------------------GSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N G+ +LH A+ ++ +LL+
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 95 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC 154
N + G TPL +AA Y L +L++ GA+VN + TPL IA++ G+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
V LLL GA + ++ P+H AA+ GH +I ++L+ N +SP++ A
Sbjct: 255 VRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE- 273
G H DC+ +LL+ D + +P+ +A C + +LL GA+ N
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLDKGAKPNSR 367
Query: 274 -------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 310
LH+A K + L+ G S+ H+ F+ H
Sbjct: 368 ALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 114 bits (286), Expect = 1e-25
Identities = 70/233 (30%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT + LH AA GH +I +ILL+ GA A T +P+ +A + +D +RLLLQ+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A ++ ++ LH A+ + + K+LL KGA + G TPL +A + +
Sbjct: 328 DAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ +GA+++ TPL +A+ GH V+ LL GA P++ + + P+H A
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMA 444
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
A+ GHT++ L+ + + +P++ A GH + +++LL N +P+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 106 bits (265), Expect = 4e-23
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 37/300 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA+ +GH K+V LL TT + T L +A GQ +V+R L+ +GANV
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GAN+ + G TPL VA Q G ++ L
Sbjct: 105 N-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 126 ISSGA---------------------------NVNCQALDKA--TPLFIAAQEGHTKCVE 156
I+ G + N L K TPL IAA + +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
LLL+ GA + + P+H A++ G+ ++ LL+ + ++++P++ A
Sbjct: 224 LLLNRGASVNF--TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 276
GH EILL +G QA G SP+ MA Q D V +LL+Y A+I+++ L
Sbjct: 282 NGHVRISEILLDHG--APIQAKTKNGL-SPIHMAAQGD--HLDCVRLLLQYDAEIDDITL 336
Score = 106 bits (264), Expect = 5e-23
Identities = 63/196 (32%), Positives = 108/196 (55%), Gaps = 5/196 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 64 NVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
N N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++ +
Sbjct: 660 NGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAK 775
Query: 183 QMGHTKILDLLIPLTN 198
++G+ + D+L +T+
Sbjct: 776 RLGYISVTDVLKVVTD 791
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT G+ LH AA QGH IV +LL+ GA PN + + TTPL +A G I V +L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--- 786
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEII 89
V S + H+ SF E + I
Sbjct: 787 -KVVTDETSFVLVSDKHRMSFPETVDEI 813
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 11/174 (6%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T AA+ G L+ + +G ++N + L +A++EGH K V LL + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIIL 71
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+H AA G +++ L+ +P+Y A H + ++ LL
Sbjct: 72 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG----AQINELHLA 277
NG + GF +P+ +A Q+ E +V L+ YG ++ LH+A
Sbjct: 132 ENG--ANQNVATEDGF-TPLAVALQQGHE--NVVAHLINYGTKGKVRLPALHIA 180
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 130 bits (328), Expect = 2e-30
Identities = 93/301 (30%), Positives = 145/301 (48%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+ LLL+ G
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+++ + G LH ASF + I+K LL++GA+ + TPL +AA+ G E
Sbjct: 395 ASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL--------------- 167
L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513
Query: 168 ----------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
C P+H AA+ G ++ +LL+ G N ++P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ AV + D +++LL G SP + A G++ A Q E + LL+YG
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSLLQYGGSA 628
Query: 272 N 272
N
Sbjct: 629 N 629
Score = 128 bits (322), Expect = 9e-30
Identities = 103/358 (28%), Positives = 172/358 (48%), Gaps = 46/358 (12%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G +V+ L+ +G
Sbjct: 110 KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK 169
Query: 65 ----VNGSH------------------------SMCGWNSLHQASFQENAEIIKLLLRKG 96
+ H S G+ LH A+ EN + +LLL +G
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ GITPL +A++ G + + +L+ GA + + D+ TPL AA+ GH + E
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
+LL GA + + PIH AAQ H + LL+ D L+ ++P++ A
Sbjct: 290 ILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---- 272
GH ++LL G P+++A F +P+ +A +K+ ++ +LLK GA I+
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVMELLLKTGASIDAVTE 402
Query: 273 ----ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLL 326
LH+A + + I + L++G S N E H + A+A + E +LL
Sbjct: 403 SGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAARAGHTEVAKYLL 457
Score = 127 bits (320), Expect = 2e-29
Identities = 94/274 (34%), Positives = 139/274 (50%), Gaps = 8/274 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 558 RDAHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHL 674
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AQ GH + D+LI T +P++ A G+ ++ LL+ + D A
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTK 732
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 274
G+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 733 LGY-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 118 bits (295), Expect = 1e-26
Identities = 94/351 (26%), Positives = 157/351 (44%), Gaps = 52/351 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V++ LL++G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 63 ANVN----------------------------GSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N G+ +LH A+ ++ +LL+
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 95 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC 154
N + G TPL +AA Y L +L++ GA+VN + TPL IA++ G+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
V LLL GA + ++ P+H AA+ GH +I ++L+ N +SP++ A
Sbjct: 255 VRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE- 273
G H DC+ +LL+ D + +P+ +A C + +LL GA+ N
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLDKGAKPNSR 367
Query: 274 -------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 310
LH+A K + L+ G S+ H+ F+ H
Sbjct: 368 ALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 114 bits (286), Expect = 1e-25
Identities = 70/233 (30%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT + LH AA GH +I +ILL+ GA A T +P+ +A + +D +RLLLQ+
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQY 327
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A ++ ++ LH A+ + + K+LL KGA + G TPL +A + +
Sbjct: 328 DAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ +GA+++ TPL +A+ GH V+ LL GA P++ + + P+H A
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV--SNVKVETPLHMA 444
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
A+ GHT++ L+ + + +P++ A GH + +++LL N +P+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Score = 106 bits (265), Expect = 4e-23
Identities = 93/300 (31%), Positives = 143/300 (47%), Gaps = 37/300 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA+ +GH K+V LL TT + T L +A GQ +V+R L+ +GANV
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GAN+ + G TPL VA Q G ++ L
Sbjct: 105 N-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 126 ISSGA---------------------------NVNCQALDKA--TPLFIAAQEGHTKCVE 156
I+ G + N L K TPL IAA + +
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 157 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVF 216
LLL+ GA + + P+H A++ G+ ++ LL+ + ++++P++ A
Sbjct: 224 LLLNRGASVNF--TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 281
Query: 217 GGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL 276
GH EILL +G QA G SP+ MA Q D V +LL+Y A+I+++ L
Sbjct: 282 NGHVRISEILLDHG--APIQAKTKNGL-SPIHMAAQGD--HLDCVRLLLQYDAEIDDITL 336
Score = 106 bits (264), Expect = 5e-23
Identities = 63/196 (32%), Positives = 108/196 (55%), Gaps = 5/196 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 64 NVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
N N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++ +
Sbjct: 660 NGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIAK 775
Query: 183 QMGHTKILDLLIPLTN 198
++G+ + D+L +T+
Sbjct: 776 RLGYISVTDVLKVVTD 791
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT G+ LH AA QGH IV +LL+ GA PN + + TTPL +A G I V +L
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--- 786
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEII 89
V S + H+ SF E + I
Sbjct: 787 -KVVTDETSFVLVSDKHRMSFPETVDEI 813
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 11/174 (6%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T AA+ G L+ + +G ++N + L +A++EGH K V LL + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIIL 71
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+H AA G +++ L+ +P+Y A H + ++ LL
Sbjct: 72 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG----AQINELHLA 277
NG + GF +P+ +A Q+ E +V L+ YG ++ LH+A
Sbjct: 132 ENG--ANQNVATEDGF-TPLAVALQQGHE--NVVAHLINYGTKGKVRLPALHIA 180
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 127 bits (319), Expect = 2e-29
Identities = 92/301 (30%), Positives = 156/301 (51%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+ LL+++G
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 400
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+ G++E +
Sbjct: 401 ASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 459
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD---------LYCNEDS 173
L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD L+ +
Sbjct: 460 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 519
Query: 174 WQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
Q+ P+H AA+ G + LL+ A G N ++P+
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 579
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ A ++ +LL G SP A A + +P+ +A +K+ I + LL YGA+
Sbjct: 580 HVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTLLNYGAET 634
Query: 272 N 272
N
Sbjct: 635 N 635
Score = 125 bits (315), Expect = 6e-29
Identities = 70/198 (35%), Positives = 109/198 (55%), Gaps = 3/198 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL GAN+
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ ++ L
Sbjct: 668 HMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 726
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A ++G
Sbjct: 727 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AKRLG 784
Query: 186 HTKILDLLIPLTNRACDT 203
+ ++D L +T T
Sbjct: 785 YISVVDTLKVVTEEVTTT 802
Score = 125 bits (313), Expect = 1e-28
Identities = 89/273 (32%), Positives = 141/273 (51%), Gaps = 14/273 (5%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 506 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 566 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 624
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
S L++ GA N TPL +A+QEGHT V LLL GA +++ + S +H AA
Sbjct: 625 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA--NIHMSTKSGLTSLHLAA 682
Query: 183 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 239
Q + D+ LT D + +P+ A G+ + LL+ G + +A+
Sbjct: 683 QEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 739
Query: 240 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 740 GY---TPLHQAAQQG--HTHIINVLLQHGAKPN 767
Score = 115 bits (288), Expect = 8e-26
Identities = 76/263 (28%), Positives = 133/263 (50%), Gaps = 38/263 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+A+ G ++V++L++ GA+ NA + TPL++A + IDV++ LL++G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 63 AN----------------------------VNGSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N + +LH A+ +++ + LLL+
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 95 KGANKECQD--------DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 146
N + Q + G TPL +AA YG + ++L++ GA V+ A + TPL +A
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 252
Query: 147 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 206
++ G+T V+LLL G D + P+H AA+ GH ++++LL+ N
Sbjct: 253 SKRGNTNMVKLLLDRGGQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 207 KVSPVYSAVFGGHEDCLEILLRN 229
+SP++ A G H +C++ LL++
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQH 333
Score = 112 bits (279), Expect = 9e-25
Identities = 90/310 (29%), Positives = 146/310 (47%), Gaps = 45/310 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALHLAA +GH +VQ LL G+ ++ T + T L +A GQ +V+++L++ GAN+
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + +++K LL GAN+ + G TPL VA Q G ++++IL
Sbjct: 103 N-AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Query: 126 -------------------------------------ISSGANVNCQALDKATPLFIAAQ 148
+ S VN TPL IAA
Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
Query: 149 EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV 208
G+ LLL+ GA D P+H A++ G+T ++ LL+ + + +
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 279
Query: 209 SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG 268
+P++ A GH+ +E+LL G A+ SP+ MA Q D V LL++
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLAR---TKNGLSPLHMAAQGD--HVECVKHLLQHK 334
Query: 269 AQINELHLAY 278
A ++++ L Y
Sbjct: 335 APVDDVTLDY 344
Score = 112 bits (279), Expect = 9e-25
Identities = 86/305 (28%), Positives = 142/305 (46%), Gaps = 43/305 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ----- 60
GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G + +LL+
Sbjct: 109 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG 168
Query: 61 --------------------------HGANVNGSHSM-----CGWNSLHQASFQENAEII 89
H A+V + G+ LH A+ N +
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 90 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 149
LLL +GA + GITPL VA++ G + +L+ G ++ + D TPL AA+
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 209
GH + VELLL GA L + P+H AAQ H + + L+ D L+ ++
Sbjct: 289 GHDQVVELLLERGA--PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 346
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGA 269
++ A GH ++LL +P+A+A F +P+ +A +K+ ++ +L+KYGA
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGF---TPLHIACKKN--RIKVMELLVKYGA 401
Query: 270 QINEL 274
I +
Sbjct: 402 SIQAI 406
Score = 108 bits (271), Expect = 7e-24
Identities = 77/232 (33%), Positives = 120/232 (51%), Gaps = 3/232 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH+A+ +G+ +V++LL+ G +A T + TPL A +G V+ LLL+ GA +
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ + G + LH A+ ++ E +K LL+ A + +T L VAA G +L
Sbjct: 305 L-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ AN N +AL+ TPL IA ++ K +ELL+ GA + +S PIH AA MG
Sbjct: 364 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS--IQAITESGLTPIHVAAFMG 421
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
H I+ LL+ T + + ++ A G + + LLRNG DA+A
Sbjct: 422 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
Score = 108 bits (269), Expect = 1e-23
Identities = 71/234 (30%), Positives = 122/234 (52%), Gaps = 3/234 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT +G LH AA GH ++V++LLE GA A T +PL +A + ++ ++ LLQH
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A V+ ++ +LH A+ + + KLLL K AN + G TPL +A + +++
Sbjct: 334 KAPVD-DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ GA++ TP+ +AA GH V LLL +GA PD+ + +H A
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMA 450
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
A+ G +++ L+ + +P++ A G + +++LL++ PDA
Sbjct: 451 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Score = 104 bits (260), Expect = 1e-22
Identities = 71/264 (26%), Positives = 123/264 (46%), Gaps = 8/264 (3%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T +GF LH+AA G + ++LL+ A ++ TPL +A V LLL+
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA+ + + + G+ LH A+ + +I LL GA G+TPL +A+Q G +
Sbjct: 597 KGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+++L+ GAN++ T L +AAQE ++L GAD D + P+
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK--LGYTPLIV 713
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
A G+ K+++ L+ N +P++ A GH + +LL++G P+A
Sbjct: 714 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA-- 771
Query: 241 FGFSSPVCMAFQKDCEFFGIVNIL 264
+ +A K + +V+ L
Sbjct: 772 ---NGNTALAIAKRLGYISVVDTL 792
Score = 97.4 bits (241), Expect = 2e-20
Identities = 72/237 (30%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
AA G+ V L+ G D N L LA + G + +++ LL G++V+ S +
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD-SATKK 75
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
G +LH AS AE++K+L+++GAN Q G TPL++AAQ ++ + L+ +GAN
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP-IHAAAQMGHTKILD 191
+ D TPL +A Q+GH + V +LL + + +LP +H AA+ TK
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLEND-------TKGKVRLPALHIAARKDDTKSAA 188
Query: 192 LLIP-----------LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
LL+ + NR ++G +P++ A G+ + +LL G + D A
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTA 242
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 127 bits (319), Expect = 2e-29
Identities = 92/301 (30%), Positives = 156/301 (51%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+ LL+++G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+ G++E +
Sbjct: 422 ASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD---------LYCNEDS 173
L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD L+ +
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540
Query: 174 WQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
Q+ P+H AA+ G + LL+ A G N ++P+
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ A ++ +LL G SP A A + +P+ +A +K+ I + LL YGA+
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTLLNYGAET 655
Query: 272 N 272
N
Sbjct: 656 N 656
Score = 125 bits (315), Expect = 6e-29
Identities = 70/198 (35%), Positives = 109/198 (55%), Gaps = 3/198 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL GAN+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ ++ L
Sbjct: 689 HMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A ++G
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AKRLG 805
Query: 186 HTKILDLLIPLTNRACDT 203
+ ++D L +T T
Sbjct: 806 YISVVDTLKVVTEEVTTT 823
Score = 125 bits (313), Expect = 1e-28
Identities = 89/273 (32%), Positives = 141/273 (51%), Gaps = 14/273 (5%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 587 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
S L++ GA N TPL +A+QEGHT V LLL GA +++ + S +H AA
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA--NIHMSTKSGLTSLHLAA 703
Query: 183 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 239
Q + D+ LT D + +P+ A G+ + LL+ G + +A+
Sbjct: 704 QEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760
Query: 240 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 761 GY---TPLHQAAQQG--HTHIINVLLQHGAKPN 788
Score = 115 bits (288), Expect = 8e-26
Identities = 76/263 (28%), Positives = 133/263 (50%), Gaps = 38/263 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+A+ G ++V++L++ GA+ NA + TPL++A + IDV++ LL++G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 63 AN----------------------------VNGSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N + +LH A+ +++ + LLL+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 95 KGANKECQD--------DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 146
N + Q + G TPL +AA YG + ++L++ GA V+ A + TPL +A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 147 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 206
++ G+T V+LLL G D + P+H AA+ GH ++++LL+ N
Sbjct: 274 SKRGNTNMVKLLLDRGGQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 207 KVSPVYSAVFGGHEDCLEILLRN 229
+SP++ A G H +C++ LL++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQH 354
Score = 112 bits (279), Expect = 9e-25
Identities = 90/310 (29%), Positives = 146/310 (47%), Gaps = 45/310 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALHLAA +GH +VQ LL G+ ++ T + T L +A GQ +V+++L++ GAN+
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + +++K LL GAN+ + G TPL VA Q G ++++IL
Sbjct: 124 N-AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 126 -------------------------------------ISSGANVNCQALDKATPLFIAAQ 148
+ S VN TPL IAA
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 149 EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV 208
G+ LLL+ GA D P+H A++ G+T ++ LL+ + + +
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 209 SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG 268
+P++ A GH+ +E+LL G A+ SP+ MA Q D V LL++
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLAR---TKNGLSPLHMAAQGD--HVECVKHLLQHK 355
Query: 269 AQINELHLAY 278
A ++++ L Y
Sbjct: 356 APVDDVTLDY 365
Score = 112 bits (279), Expect = 9e-25
Identities = 86/305 (28%), Positives = 142/305 (46%), Gaps = 43/305 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ----- 60
GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G + +LL+
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG 189
Query: 61 --------------------------HGANVNGSHSM-----CGWNSLHQASFQENAEII 89
H A+V + G+ LH A+ N +
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 90 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 149
LLL +GA + GITPL VA++ G + +L+ G ++ + D TPL AA+
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 209
GH + VELLL GA L + P+H AAQ H + + L+ D L+ ++
Sbjct: 310 GHDQVVELLLERGA--PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGA 269
++ A GH ++LL +P+A+A F +P+ +A +K+ ++ +L+KYGA
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGF---TPLHIACKKN--RIKVMELLVKYGA 422
Query: 270 QINEL 274
I +
Sbjct: 423 SIQAI 427
Score = 108 bits (271), Expect = 7e-24
Identities = 77/232 (33%), Positives = 120/232 (51%), Gaps = 3/232 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH+A+ +G+ +V++LL+ G +A T + TPL A +G V+ LLL+ GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ + G + LH A+ ++ E +K LL+ A + +T L VAA G +L
Sbjct: 326 L-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ AN N +AL+ TPL IA ++ K +ELL+ GA + +S PIH AA MG
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS--IQAITESGLTPIHVAAFMG 442
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
H I+ LL+ T + + ++ A G + + LLRNG DA+A
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Score = 108 bits (269), Expect = 1e-23
Identities = 71/234 (30%), Positives = 122/234 (52%), Gaps = 3/234 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT +G LH AA GH ++V++LLE GA A T +PL +A + ++ ++ LLQH
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A V+ ++ +LH A+ + + KLLL K AN + G TPL +A + +++
Sbjct: 355 KAPVD-DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ GA++ TP+ +AA GH V LLL +GA PD+ + +H A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMA 471
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
A+ G +++ L+ + +P++ A G + +++LL++ PDA
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Score = 104 bits (260), Expect = 1e-22
Identities = 71/264 (26%), Positives = 123/264 (46%), Gaps = 8/264 (3%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T +GF LH+AA G + ++LL+ A ++ TPL +A V LLL+
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA+ + + + G+ LH A+ + +I LL GA G+TPL +A+Q G +
Sbjct: 618 KGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+++L+ GAN++ T L +AAQE ++L GAD D + P+
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK--LGYTPLIV 734
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
A G+ K+++ L+ N +P++ A GH + +LL++G P+A
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA-- 792
Query: 241 FGFSSPVCMAFQKDCEFFGIVNIL 264
+ +A K + +V+ L
Sbjct: 793 ---NGNTALAIAKRLGYISVVDTL 813
Score = 97.4 bits (241), Expect = 2e-20
Identities = 72/237 (30%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
AA G+ V L+ G D N L LA + G + +++ LL G++V+ S +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD-SATKK 96
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
G +LH AS AE++K+L+++GAN Q G TPL++AAQ ++ + L+ +GAN
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP-IHAAAQMGHTKILD 191
+ D TPL +A Q+GH + V +LL + + +LP +H AA+ TK
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLEND-------TKGKVRLPALHIAARKDDTKSAA 209
Query: 192 LLIP-----------LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
LL+ + NR ++G +P++ A G+ + +LL G + D A
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 127 bits (319), Expect = 2e-29
Identities = 92/301 (30%), Positives = 156/301 (51%), Gaps = 37/301 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+ LL+++G
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYG 421
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+ G++E +
Sbjct: 422 ASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD---------LYCNEDS 173
L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD L+ +
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540
Query: 174 WQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
Q+ P+H AA+ G + LL+ A G N ++P+
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 212 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
+ A ++ +LL G SP A A + +P+ +A +K+ I + LL YGA+
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTLLNYGAET 655
Query: 272 N 272
N
Sbjct: 656 N 656
Score = 125 bits (315), Expect = 6e-29
Identities = 70/198 (35%), Positives = 109/198 (55%), Gaps = 3/198 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL GAN+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ ++ L
Sbjct: 689 HMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A ++G
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AKRLG 805
Query: 186 HTKILDLLIPLTNRACDT 203
+ ++D L +T T
Sbjct: 806 YISVVDTLKVVTEEVTTT 823
Score = 125 bits (313), Expect = 1e-28
Identities = 89/273 (32%), Positives = 141/273 (51%), Gaps = 14/273 (5%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 587 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
S L++ GA N TPL +A+QEGHT V LLL GA +++ + S +H AA
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA--NIHMSTKSGLTSLHLAA 703
Query: 183 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 239
Q + D+ LT D + +P+ A G+ + LL+ G + +A+
Sbjct: 704 QEDKVNVADI---LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760
Query: 240 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 761 GY---TPLHQAAQQG--HTHIINVLLQHGAKPN 788
Score = 115 bits (288), Expect = 8e-26
Identities = 76/263 (28%), Positives = 133/263 (50%), Gaps = 38/263 (14%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T +G ALH+A+ G ++V++L++ GA+ NA + TPL++A + IDV++ LL++G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 63 AN----------------------------VNGSHSMCGWNSLHQASFQENAEIIKLLLR 94
AN N + +LH A+ +++ + LLL+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 95 KGANKECQD--------DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 146
N + Q + G TPL +AA YG + ++L++ GA V+ A + TPL +A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 147 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 206
++ G+T V+LLL G D + P+H AA+ GH ++++LL+ N
Sbjct: 274 SKRGNTNMVKLLLDRGGQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 207 KVSPVYSAVFGGHEDCLEILLRN 229
+SP++ A G H +C++ LL++
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQH 354
Score = 112 bits (279), Expect = 9e-25
Identities = 90/310 (29%), Positives = 146/310 (47%), Gaps = 45/310 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALHLAA +GH +VQ LL G+ ++ T + T L +A GQ +V+++L++ GAN+
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + +++K LL GAN+ + G TPL VA Q G ++++IL
Sbjct: 124 N-AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 126 -------------------------------------ISSGANVNCQALDKATPLFIAAQ 148
+ S VN TPL IAA
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 149 EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV 208
G+ LLL+ GA D P+H A++ G+T ++ LL+ + + +
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 209 SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG 268
+P++ A GH+ +E+LL G A+ SP+ MA Q D V LL++
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLAR---TKNGLSPLHMAAQGD--HVECVKHLLQHK 355
Query: 269 AQINELHLAY 278
A ++++ L Y
Sbjct: 356 APVDDVTLDY 365
Score = 112 bits (279), Expect = 9e-25
Identities = 86/305 (28%), Positives = 142/305 (46%), Gaps = 43/305 (14%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ----- 60
GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G + +LL+
Sbjct: 130 GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG 189
Query: 61 --------------------------HGANVNGSHSM-----CGWNSLHQASFQENAEII 89
H A+V + G+ LH A+ N +
Sbjct: 190 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249
Query: 90 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 149
LLL +GA + GITPL VA++ G + +L+ G ++ + D TPL AA+
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 209
GH + VELLL GA L + P+H AAQ H + + L+ D L+ ++
Sbjct: 310 GHDQVVELLLERGA--PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGA 269
++ A GH ++LL +P+A+A F +P+ +A +K+ ++ +L+KYGA
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGF---TPLHIACKKN--RIKVMELLVKYGA 422
Query: 270 QINEL 274
I +
Sbjct: 423 SIQAI 427
Score = 108 bits (271), Expect = 7e-24
Identities = 77/232 (33%), Positives = 120/232 (51%), Gaps = 3/232 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH+A+ +G+ +V++LL+ G +A T + TPL A +G V+ LLL+ GA +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ + G + LH A+ ++ E +K LL+ A + +T L VAA G +L
Sbjct: 326 L-ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ AN N +AL+ TPL IA ++ K +ELL+ GA + +S PIH AA MG
Sbjct: 385 LDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGAS--IQAITESGLTPIHVAAFMG 442
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
H I+ LL+ T + + ++ A G + + LLRNG DA+A
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Score = 108 bits (269), Expect = 1e-23
Identities = 71/234 (30%), Positives = 122/234 (52%), Gaps = 3/234 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT +G LH AA GH ++V++LLE GA A T +PL +A + ++ ++ LLQH
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A V+ ++ +LH A+ + + KLLL K AN + G TPL +A + +++
Sbjct: 355 KAPVD-DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ GA++ TP+ +AA GH V LLL +GA PD+ + +H A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV--TNIRGETALHMA 471
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
A+ G +++ L+ + +P++ A G + +++LL++ PDA
Sbjct: 472 ARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Score = 104 bits (260), Expect = 1e-22
Identities = 71/264 (26%), Positives = 123/264 (46%), Gaps = 8/264 (3%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T +GF LH+AA G + ++LL+ A ++ TPL +A V LLL+
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA+ + + + G+ LH A+ + +I LL GA G+TPL +A+Q G +
Sbjct: 618 KGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+++L+ GAN++ T L +AAQE ++L GAD D + P+
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTK--LGYTPLIV 734
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
A G+ K+++ L+ N +P++ A GH + +LL++G P+A
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA-- 792
Query: 241 FGFSSPVCMAFQKDCEFFGIVNIL 264
+ +A K + +V+ L
Sbjct: 793 ---NGNTALAIAKRLGYISVVDTL 813
Score = 97.4 bits (241), Expect = 2e-20
Identities = 72/237 (30%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
AA G+ V L+ G D N L LA + G + +++ LL G++V+ S +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD-SATKK 96
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
G +LH AS AE++K+L+++GAN Q G TPL++AAQ ++ + L+ +GAN
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP-IHAAAQMGHTKILD 191
+ D TPL +A Q+GH + V +LL + + +LP +H AA+ TK
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLEND-------TKGKVRLPALHIAARKDDTKSAA 209
Query: 192 LLIP-----------LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 237
LL+ + NR ++G +P++ A G+ + +LL G + D A
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 122 bits (305), Expect = 9e-28
Identities = 81/271 (29%), Positives = 139/271 (51%), Gaps = 8/271 (2%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K GF LH+A + K++++LL+ GA A T TP+ +A G ++++ L+ H
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
GA+ N ++ + G +LH A+ AE+++ L++ GA E + TPL ++A+ GK +
Sbjct: 456 GASPNTTN-VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 514
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ L+ GA+ N TPL ++A+EGH LL GA L P+H A
Sbjct: 515 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA--SLSITTKKGFTPLHVA 572
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVF 241
A+ G ++ +LL+ + G + ++P++ A ++ +LL G SP A A +
Sbjct: 573 AKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 632
Query: 242 GFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ +A +K+ I LL+YGA N
Sbjct: 633 ---TPLHIAAKKN--QMDIATTLLEYGADAN 658
Score = 120 bits (302), Expect = 2e-27
Identities = 82/301 (27%), Positives = 150/301 (49%), Gaps = 22/301 (7%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
GF L++AA + H ++V+ LL+ GA + T + TPL +A++ G V+ LLL+
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE----- 194
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + +LH A+ +++ + LLL+ N + + G TPL +AA YG + ++L
Sbjct: 195 NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
++ A V+ A + TPL +A++ G+ V+LLL GA D + P+H A+ G
Sbjct: 255 LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG--LTPLHCGARSG 312
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSS 245
H +++++L+ N +SP++ A G H +C+++LL++ D + + +
Sbjct: 313 HEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD---VTNDYLT 369
Query: 246 PVCMAFQKDCEFFGIVNILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCS 297
+ +A C + + +LL A N LH+A K + + L+ G S
Sbjct: 370 ALHVA--AHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA--CKKNRIKVMELLLKHGAS 425
Query: 298 L 298
+
Sbjct: 426 I 426
Score = 115 bits (289), Expect = 6e-26
Identities = 67/198 (33%), Positives = 106/198 (53%), Gaps = 3/198 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G+ LH+AA + I LLE GAD NA T + + LA + G +D++ LLL ANV
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N S+ G LH A+ ++ + ++L+ +GA+ + Q G TPL V YG ++ ++ L
Sbjct: 691 NLSNKS-GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ A VN + + TPL AAQ+GHT + +LL + A P+ + L I A ++G
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI--ARRLG 807
Query: 186 HTKILDLLIPLTNRACDT 203
+ ++D L +T T
Sbjct: 808 YISVVDTLKIVTEETMTT 825
Score = 112 bits (279), Expect = 9e-25
Identities = 74/231 (32%), Positives = 127/231 (54%), Gaps = 7/231 (3%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALHLA+ +GH ++V LL+ A+ +A T + T L +A GQ +V+++L+ +GANV
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + S G+ L+ A+ + + E++K LL GA++ + G TPL VA Q G + +S+L
Sbjct: 134 N-AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ + + + + L IAA++ TK LLL + + D+ S P+H AA G
Sbjct: 193 LEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV--ESKSGFTPLHIAAHYG 246
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 236
+ + LL+ T N ++P++ A G+ + +++LL G DA+
Sbjct: 247 NINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Score = 111 bits (278), Expect = 1e-24
Identities = 79/265 (29%), Positives = 127/265 (47%), Gaps = 36/265 (13%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G+ LHL+A +GH + LL+ GA + TT + TPL +A + G+++V LLLQ
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
A+ + + G LH A+ +N ++ LLL +GA+ G TPL +AA+ +++
Sbjct: 589 ASPDAA-GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
Query: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
+ L+ GA+ N + +AAQEGH V LLL A+ +L + S P+H AA
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL--SNKSGLTPLHLAA 705
Query: 183 Q----------------------MGHT-----------KILDLLIPLTNRACDTGLNKVS 209
Q MG+T KI++ L+ + + N +
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPD 234
P++ A GH + +LL+N SP+
Sbjct: 766 PLHQAAQQGHTHIINVLLQNNASPN 790
Score = 103 bits (258), Expect = 2e-22
Identities = 79/304 (25%), Positives = 147/304 (48%), Gaps = 18/304 (5%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT +G LH A GH ++V++LL+ A + T +PL +A + ++ ++LLLQH
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
V+ + +LH A+ + ++ K+LL K AN + G TPL +A + +++
Sbjct: 357 NVPVDDVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKV 415
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ +L+ GA++ TP+ +AA GH V L+ GA P+ + +H A
Sbjct: 416 MELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN--TTNVRGETALHMA 473
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVF 241
A+ G +++ L+ + + +P++ + G D ++ LL+ G SP+A +
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 242 GFSSPVCMAFQKDCEFFGIVNILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLR 293
+P+ ++ ++ E + LL +GA ++ LH+A KY K + L+
Sbjct: 534 ---TPLHLSAREGHE--DVAAFLLDHGASLSITTKKGFTPLHVA--AKYGKLEVANLLLQ 586
Query: 294 KGCS 297
K S
Sbjct: 587 KSAS 590
Score = 99.8 bits (247), Expect = 5e-21
Identities = 80/272 (29%), Positives = 130/272 (47%), Gaps = 14/272 (5%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTP-LFLAVENGQIDVLRLLL 59
+ T +GF L +A QGH ++V +LLE N T + P L +A LLL
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLL 222
Query: 60 QHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKL 119
Q+ N + S G+ LH A+ N + LLL + A + ITPL VA++ G
Sbjct: 223 QNDNNAD-VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281
Query: 120 ESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIH 179
+ +L+ GA ++ + D TPL A+ GH + VE+LL A + + P+H
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA--PILSKTKNGLSPLH 339
Query: 180 AAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 239
A Q H + LL+ D + ++ ++ A GH ++LL +P+A+A
Sbjct: 340 MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399
Query: 240 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
F +P+ +A +K+ ++ +LLK+GA I
Sbjct: 400 GF---TPLHIACKKN--RIKVMELLLKHGASI 426
Score = 89.0 bits (219), Expect = 8e-18
Identities = 61/208 (29%), Positives = 110/208 (52%), Gaps = 14/208 (6%)
Query: 30 ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEII 89
+D NA+ L A G ++ +++G ++N + G N+LH AS + + E++
Sbjct: 39 SDANASYLR-------AARAGHLEKALDYIKNGVDINICNQN-GLNALHLASKEGHVEVV 90
Query: 90 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 149
LL++ AN + G T L +A+ G+ E + +L+++GANVN Q+ + TPL++AAQE
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 209
H + V+ LL +GA L ED + P+ A Q GH +++ LL+ + G ++
Sbjct: 151 NHLEVVKFLLDNGASQSL-ATEDGF-TPLAVALQQGHDQVVSLLLENDTK----GKVRLP 204
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPDAQA 237
++ A +LL+N + D ++
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVES 232
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/65 (36%), Positives = 35/65 (53%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T G+ LH+ G+ KIV LL+ A NA T TPL A + G ++ +LLQ+
Sbjct: 726 QTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQN 785
Query: 62 GANVN 66
A+ N
Sbjct: 786 NASPN 790
Score = 45.1 bits (105), Expect = 1e-04
Identities = 24/57 (42%), Positives = 31/57 (54%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 58
KT G+ LH AA QGH I+ +LL+ A PN T+ T L +A G I V+ L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 112 bits (280), Expect = 7e-25
Identities = 80/266 (30%), Positives = 131/266 (49%), Gaps = 9/266 (3%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
A+H AA GH ++V++L+ GA+ + TPL A +G I V++ LL G ++N
Sbjct: 176 AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP 235
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL-FVAAQYGKLESLSILIS 127
++ G LH A + ++ L+ GA +++ G TPL F AA L +L+
Sbjct: 236 NAY-GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 128 SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT 187
+GA+VN ++ D TPL + A G + ++ SGA D C + + P+H AA+ GH
Sbjct: 295 NGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID--CEDKNGNTPLHIAARYGHE 352
Query: 188 KILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPV 247
+++ LI G++ + P++ A G DC LL +G+ D FG +
Sbjct: 353 LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD--DFGRTCLH 410
Query: 248 CMAFQKDCEFFGIVNILLKYGAQINE 273
A + E +N+LL GA N+
Sbjct: 411 AAAAGGNLE---CLNLLLNTGADFNK 433
Score = 100 bits (248), Expect = 3e-21
Identities = 75/237 (31%), Positives = 115/237 (48%), Gaps = 18/237 (7%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K + + LH AAS G +V+ LL+ G D N TPL +A NGQ V+ L+
Sbjct: 202 KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
Query: 62 GANVNGSHSMCGWNSLH-QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA VN + G+ LH A+ A ++LL+ GA+ + G TPL + A +G+
Sbjct: 262 GAIVNQKNEK-GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+I SGA ++C+ + TPL IAA+ GH + L++SGAD P+H
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK--RGIHGMFPLHL 378
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSP-------VYSAVFGGHEDCLEILLRNG 230
AA G + L+ +G + +P +++A GG+ +CL +LL G
Sbjct: 379 AALSGFSDCCRKLL-------SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG 428
Score = 99.4 bits (246), Expect = 6e-21
Identities = 76/228 (33%), Positives = 110/228 (48%), Gaps = 16/228 (7%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LH A + + VQ+LL+ AD NA TPL +A N + L+ +NVN S
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS- 136
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
G +LH A+F + E++KLLL +GAN D + AA G +E + +L+S G
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG 196
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD---PDLYCNEDSWQLPIHAAAQMGH 186
A V C+ TPL AA G V+ LL G D P+ Y N P+H A G
Sbjct: 197 AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN-----TPLHVACYNGQ 251
Query: 187 TKILDLLI---PLTNRACDTGLNKVSPVYSAVFGGHED-CLEILLRNG 230
+++ LI + N+ + G +P++ A H CLE+L+ NG
Sbjct: 252 DVVVNELIDCGAIVNQKNEKGF---TPLHFAAASTHGALCLELLVGNG 296
Score = 95.9 bits (237), Expect = 7e-20
Identities = 75/237 (31%), Positives = 113/237 (47%), Gaps = 16/237 (6%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH+AA GH ++ L+ +GAD + PL LA +G D R LL G ++
Sbjct: 339 GNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDI 398
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ G LH A+ N E + LLL GA+ +D FG +PL AA + L L
Sbjct: 399 DTPDDF-GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFAL 457
Query: 126 ISSGANVNCQALDKATPL-FIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQM 184
+ SGA+VN TPL + A + KC+E LL + A+P + + +H +A
Sbjct: 458 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI--RDKQGYNAVHYSAAY 515
Query: 185 GHTKILDLL---IPL--------TNRACDT-GLNKVSPVYSAVFGGHEDCLEILLRN 229
GH L L+ PL T+ D+ +SP++ A + GH LE+L+++
Sbjct: 516 GHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572
Score = 93.2 bits (230), Expect = 4e-19
Identities = 62/225 (27%), Positives = 110/225 (48%), Gaps = 9/225 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LHLAA GH + +++L+++ D + TPL LA G ++ + +L+ GA++
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANK---ECQDDFGITPLFVAAQYGKLESLSILI 126
+ +H A+ ++E ++LL+ + + QD G TPL ++ G + + L+
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 127 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
+ GANV+ + T L A GH +CV+ LL GA + + PIH +A GH
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA--KCLLRDSRGRTPIHLSAACGH 731
Query: 187 TKILDLLI----PLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+L L+ + + + ++ A + GHE C+E+LL
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Score = 89.4 bits (220), Expect = 6e-18
Identities = 81/281 (28%), Positives = 124/281 (44%), Gaps = 53/281 (18%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH AA+ G+ + + +LL GAD N +PL A N L L+ GA+V
Sbjct: 405 GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
Query: 66 NGSHSMCGWNSLHQASFQE-NAEIIKLLLRKGANKECQDDFG------------------ 106
N G LH A+ + + + ++ LLR AN +D G
Sbjct: 465 NDLDER-GCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQL 523
Query: 107 ---------------------------ITPLFVAAQYGKLESLSILISSGANVNCQALDK 139
I+PL +AA +G ++L +L+ S +++ +
Sbjct: 524 IASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSG 583
Query: 140 ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI----P 195
TPL +AA +GH +CV++L++ GA L + + PIHAAA GH++ L LLI P
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGAS-ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
Query: 196 LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 236
G N +P+ +V GH DC+ LL G + DA+
Sbjct: 643 QNAVDIQDG-NGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682
Score = 82.4 bits (202), Expect = 8e-16
Identities = 81/283 (28%), Positives = 120/283 (42%), Gaps = 52/283 (18%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALH A GH + V LL+ GA TP+ L+ G I VL LLQ A++
Sbjct: 686 GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 745
Query: 66 NGSHSMC---GWNSLHQASFQENAEIIKLLLRKGANKECQ-------------------- 102
+ + + G+ +LH A + + ++LLL + ++ +
Sbjct: 746 DANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAE 805
Query: 103 --------------DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQ 148
D G TPL AA +E L +L+S A VN TPL +AA+
Sbjct: 806 MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
Query: 149 EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH-TKILDLLIPLTNRACDTGLNK 207
G T VE+L+SS A +L ++S +H A GH T L +L +T+R N
Sbjct: 866 NGQTNTVEMLVSS-ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924
Query: 208 V--SPVYSAVFGGHEDCLEILL----------RNGYSPDAQAC 238
+P++ A G ++ LL NGY+P A AC
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP-ALAC 966
Score = 77.0 bits (188), Expect = 3e-14
Identities = 72/270 (26%), Positives = 111/270 (41%), Gaps = 47/270 (17%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGAD----------------------------- 31
++ G L LAA +GH + V +L+ GA
Sbjct: 578 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Query: 32 -----PNATTLEE---TTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQ 83
NA +++ TPL L+V NG D + LL GANV+ G +LH+ +
Sbjct: 638 GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW-GRTALHRGAVT 696
Query: 84 ENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK---- 139
+ E + LL+ GA +D G TP+ ++A G + L L+ S A+++
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 140 ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR 199
T L A GH CVELLL N S P+H A + ++LI
Sbjct: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFS---PLHCAVINDNEGAAEMLIDTLGA 813
Query: 200 AC--DTGLNKVSPVYSAVFGGHEDCLEILL 227
+ T +P+++A F H +CL++LL
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
Score = 75.9 bits (185), Expect = 7e-14
Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 7/196 (3%)
Query: 76 SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ 135
SL QA F + + ++ L+ K + QD+ TPL AA G E + +LI SGA VN +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 136 ALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIP 195
TPL A + V++LL AD + + +WQ P+H AA K + L+P
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVN--ARDKNWQTPLHIAAANKAVKCAEALVP 128
Query: 196 LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 255
L + + + ++ A F GH + +++LL G + +A F + +
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-----FDKKDRRAIHWAAYM 183
Query: 256 EFFGIVNILLKYGAQI 271
+V +L+ +GA++
Sbjct: 184 GHIEVVKLLVSHGAEV 199
Score = 71.2 bits (173), Expect = 2e-12
Identities = 72/270 (26%), Positives = 119/270 (44%), Gaps = 41/270 (15%)
Query: 37 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 96
L + L A+ NG D +R L+ +VN + LH A++ +AEII+LL+ G
Sbjct: 6 LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKR-TPLHAAAYLGDAEIIELLILSG 64
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQ-------- 148
A +D +TPL A E++ +L+ A+VN + + TPL IAA
Sbjct: 65 ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
Query: 149 -------------------------EGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 183
GH + V+LLLS GA+ + + +D + IH AA
Sbjct: 125 ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD--RRAIHWAAY 182
Query: 184 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGF 243
MGH +++ LL+ +P+++A G ++ LL G D +G
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGV--DMNEPNAYG- 239
Query: 244 SSPVCMAFQKDCEFFGIVNILLKYGAQINE 273
++P+ +A + +VN L+ GA +N+
Sbjct: 240 NTPLHVACYNGQDV--VVNELIDCGAIVNQ 267
Score = 50.4 bits (119), Expect = 3e-06
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 4/161 (2%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G LH AA H + +Q+LL A N+ TPL +A ENGQ + + +L+ +
Sbjct: 822 KGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASA 881
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI---TPLFVAAQYGKLES 121
+LH A + + L+L K ++ + TPL VAA+ G
Sbjct: 882 ELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMV 941
Query: 122 LSILISSGANVNCQALDKATP-LFIAAQEGHTKCVELLLSS 161
+ L+ GA+V + TP L A + C+ L+L++
Sbjct: 942 VQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILAT 982
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 110 bits (276), Expect = 2e-24
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 3/229 (1%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA + GH ++VQ LLE GA + TPL LA G + V+ +LL +GA++
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
L A E+++LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
Query: 129 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
GA +N + K +PL +AA GHT V+LLL G+D + E + + A G
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1264
Query: 187 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
T+++ LL+ ++P+ A GG+ + +LL G +A
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
Score = 103 bits (258), Expect = 2e-22
Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 8/263 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L AA+ GH KIV++LL AD NA + T L A G +DV+++LL+ GA++ H
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE-DH 363
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A + E+ +LLL GA ++F + L +A G LE + L+ +
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 481
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT----EETQETA 537
Query: 249 MAFQKDCEFFGIVNILLKYGAQI 271
+ F + + L+K GA I
Sbjct: 538 LTLACCGGFLEVADFLIKAGADI 560
Score = 101 bits (252), Expect = 1e-21
Identities = 96/338 (28%), Positives = 157/338 (46%), Gaps = 25/338 (7%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQH 61
T EG L LA S G++++ Q+LL A+ ++ + TPL A G + +++LLL H
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A+VN + S G +L A +++K+LL GA+ E ++ G TPL A G +E
Sbjct: 324 KADVN-AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEV 382
Query: 122 LSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+L+ +GA +N + + K + L +A +GH + V LL +GAD + D +
Sbjct: 383 ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE--HKTDEMHTALME 440
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
A GH ++ LL+ + + SP+ A GGH + +L+ G S +
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---------ELHLAYCLKYEKFSIFRYF 291
+ +P+ A ++ E +V +LL GA IN L LA C + + + F
Sbjct: 501 Y---TPLMEAAREGHE--EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 292 LRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAG 329
LG + E AQ + E + +LL AG
Sbjct: 556 AGADIELGCSTPLME------AAQEGHLELVKYLLAAG 587
Score = 101 bits (251), Expect = 2e-21
Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 11/276 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNG-S 68
L LA S G ++V++LL GA+ + + TPL LA G ++++++LL GA +N +
Sbjct: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI-TPLFVAAQYGKLESLSILIS 127
S G + L A+ + +KLLL G++ Q + T L +A G+ E +S+L+
Sbjct: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1273
Query: 128 SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT 187
ANV +A TPL AA G+ + +LL GAD + S + AA GH
Sbjct: 1274 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1333
Query: 188 KILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPV 247
K +LLI +P++ A GGH D +++L++ G DA +P+
Sbjct: 1334 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI---TPL 1390
Query: 248 CMAFQKDCEFFGIVNILLKYGAQINELHL-AYCLKY 282
AF+K G V ++ ++N+ + C++Y
Sbjct: 1391 MAAFRK-----GHVKVVRYLVKEVNQFPSDSECMRY 1421
Score = 100 bits (249), Expect = 3e-21
Identities = 82/268 (30%), Positives = 132/268 (49%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G+ +V++LLE+GA TPL A G ++V RLLL++GA +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + E+++ LL GA++E + D T L A G +E +L
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA L D P+ AA+ G
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--SLEEVNDEGYTPLMEAAREG 511
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG------ADIELGCS 565
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 566 TPLMEAAQEG--HLELVKYLLAAGANVH 591
Score = 100 bits (249), Expect = 3e-21
Identities = 76/225 (33%), Positives = 106/225 (47%), Gaps = 6/225 (2%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L LAA GH ++ +L+E GA E TPL A G +++ LLL GAN+N
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
+L A E+ L++ GA+ E TPL AAQ G LE + L+++G
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAG 587
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 189
ANV+ T L A + GHT ++LL +GAD L + + P+ AA+ GH
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHVCT 645
Query: 190 LDLLIPLTNRACDTGLNKVSPVYS-AVFGGHEDCLEILLRNGYSP 233
+ LI T N V S A GGH +E+LL +G P
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/191 (36%), Positives = 104/191 (54%), Gaps = 7/191 (3%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA G ++ L++AGAD L +TPL A + G +++++ LL GANV+ +
Sbjct: 537 ALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G +L A + ++ +LL+ GA+ E + + G TPL AA+ G + ++ LIS
Sbjct: 594 -TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 129 GANVN-CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT 187
GANVN A + T L +A GH VELLL+ GADP + S L AA+ GHT
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML--IEAAKGGHT 710
Query: 188 KILDLLIPLTN 198
++ L+ N
Sbjct: 711 SVVCYLLDYPN 721
Score = 84.7 bits (208), Expect = 2e-16
Identities = 63/192 (32%), Positives = 101/192 (52%), Gaps = 8/192 (4%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G ++V L++ GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +A+ + + E++K LL GAN G T L A + G +
Sbjct: 559 DIELGCS----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAAA 182
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D L + A
Sbjct: 615 VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
Query: 183 QMGHTKILDLLI 194
GH +++LL+
Sbjct: 675 --GHLAVVELLL 684
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/152 (33%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA QG ++V +LL+ A+ TPL A G +V R+LL GA+VN
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 69 HSMCGWNS-LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 127
++ L A+ + + + +LL+ +GA+ + ++ G TPL++AA G L+ + +L+
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 128 SGANVNCQALDKATPLFIAAQEGHTKCVELLL 159
+GA+V+ K TPL A ++GH K V L+
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 72.0 bits (175), Expect = 1e-12
Identities = 70/264 (26%), Positives = 115/264 (43%), Gaps = 8/264 (3%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S+G V+ LL G N T E + L LA G ++ ++LL ANV
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L A+ + +I+KLLL A+ Q G T L A G ++ + +L+ SGA++
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL A GH + LLL +GA + + NE + + A GH +++
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRF 419
Query: 193 LIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQ 252
L+ + + A GH + +LL +G + A F SP+ +A
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLTLA-- 474
Query: 253 KDC-EFFGIVNILLKYGAQINELH 275
C + +L++ GA + E++
Sbjct: 475 -ACGGHVELAALLIERGASLEEVN 497
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/165 (27%), Positives = 79/165 (47%), Gaps = 4/165 (2%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T L +A G E + L+ GA++ + TPL +AA GH VE+LL +GAD +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+E + P+ A G ++++LL+ ++ +P+ A GG+ + ++ILL
Sbjct: 1145 Q-SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
G +++ G SP+ +A V +LL G+ IN
Sbjct: 1204 NAGAEINSRTGSKLGI-SPLMLAAMNG--HTAAVKLLLDMGSDIN 1245
Score = 53.1 bits (126), Expect = 5e-07
Identities = 39/130 (30%), Positives = 59/130 (45%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G AL A GH + +LL+AGAD + TPL A G + ++ L+ G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
ANVN + + L A + +++LLL GA+ + G T L AA+ G +
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 123 SILISSGANV 132
L+ N+
Sbjct: 714 CYLLDYPNNL 723
Score = 46.2 bits (108), Expect = 6e-05
Identities = 27/68 (39%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G L LAA+ GH +VQ+L++AGAD +A + TPL A G + V+R L++ N
Sbjct: 1352 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VN 1410
Query: 65 VNGSHSMC 72
S S C
Sbjct: 1411 QFPSDSEC 1418
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 110 bits (276), Expect = 2e-24
Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 3/229 (1%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA + GH ++VQ LLE GA + TPL LA G + V+ +LL +GA++
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
L A E+++LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 895 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
Query: 129 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
GA +N + K +PL +AA GHT V+LLL G+D + E + + A G
Sbjct: 955 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1013
Query: 187 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
T+++ LL+ ++P+ A GG+ + +LL G +A
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1062
Score = 103 bits (258), Expect = 2e-22
Identities = 80/263 (30%), Positives = 128/263 (48%), Gaps = 8/263 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L AA+ GH KIV++LL AD NA + T L A G +DV+++LL+ GA++ H
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIE-DH 363
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A + E+ +LLL GA ++F + L +A G LE + L+ +
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 481
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT----EETQETA 537
Query: 249 MAFQKDCEFFGIVNILLKYGAQI 271
+ F + + L+K GA I
Sbjct: 538 LTLACCGGFLEVADFLIKAGADI 560
Score = 101 bits (252), Expect = 1e-21
Identities = 96/338 (28%), Positives = 157/338 (46%), Gaps = 25/338 (7%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQH 61
T EG L LA S G++++ Q+LL A+ ++ + TPL A G + +++LLL H
Sbjct: 264 TEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAH 323
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
A+VN + S G +L A +++K+LL GA+ E ++ G TPL A G +E
Sbjct: 324 KADVN-AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEV 382
Query: 122 LSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+L+ +GA +N + + K + L +A +GH + V LL +GAD + D +
Sbjct: 383 ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQE--HKTDEMHTALME 440
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
A GH ++ LL+ + + SP+ A GGH + +L+ G S +
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN---------ELHLAYCLKYEKFSIFRYF 291
+ +P+ A ++ E +V +LL GA IN L LA C + + + F
Sbjct: 501 Y---TPLMEAAREGHE--EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 292 LRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAG 329
LG + E AQ + E + +LL AG
Sbjct: 556 AGADIELGCSTPLME------AAQEGHLELVKYLLAAG 587
Score = 101 bits (251), Expect = 2e-21
Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 11/276 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNG-S 68
L LA S G ++V++LL GA+ + + TPL LA G ++++++LL GA +N +
Sbjct: 903 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI-TPLFVAAQYGKLESLSILIS 127
S G + L A+ + +KLLL G++ Q + T L +A G+ E +S+L+
Sbjct: 963 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1022
Query: 128 SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT 187
ANV +A TPL AA G+ + +LL GAD + S + AA GH
Sbjct: 1023 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1082
Query: 188 KILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPV 247
K +LLI +P++ A GGH D +++L++ G DA +P+
Sbjct: 1083 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI---TPL 1139
Query: 248 CMAFQKDCEFFGIVNILLKYGAQINELHL-AYCLKY 282
AF+K G V ++ ++N+ + C++Y
Sbjct: 1140 MAAFRK-----GHVKVVRYLVKEVNQFPSDSECMRY 1170
Score = 100 bits (249), Expect = 3e-21
Identities = 82/268 (30%), Positives = 132/268 (49%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G+ +V++LLE+GA TPL A G ++V RLLL++GA +
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGI 393
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + E+++ LL GA++E + D T L A G +E +L
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA L D P+ AA+ G
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--SLEEVNDEGYTPLMEAAREG 511
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAG------ADIELGCS 565
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 566 TPLMEAAQEG--HLELVKYLLAAGANVH 591
Score = 100 bits (249), Expect = 3e-21
Identities = 76/225 (33%), Positives = 106/225 (47%), Gaps = 6/225 (2%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L LAA GH ++ +L+E GA E TPL A G +++ LLL GAN+N
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
+L A E+ L++ GA+ E TPL AAQ G LE + L+++G
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAG 587
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 189
ANV+ T L A + GHT ++LL +GAD L + + P+ AA+ GH
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD--LEHESEGGRTPLMKAARAGHVCT 645
Query: 190 LDLLIPLTNRACDTGLNKVSPVYS-AVFGGHEDCLEILLRNGYSP 233
+ LI T N V S A GGH +E+LL +G P
Sbjct: 646 VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Score = 94.0 bits (232), Expect = 2e-19
Identities = 69/191 (36%), Positives = 104/191 (54%), Gaps = 7/191 (3%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA G ++ L++AGAD L +TPL A + G +++++ LL GANV+ +
Sbjct: 537 ALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYLLAAGANVHAT 593
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G +L A + ++ +LL+ GA+ E + + G TPL AA+ G + ++ LIS
Sbjct: 594 -TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 129 GANVN-CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT 187
GANVN A + T L +A GH VELLL+ GADP + S L AA+ GHT
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML--IEAAKGGHT 710
Query: 188 KILDLLIPLTN 198
++ L+ N
Sbjct: 711 SVVCYLLDYPN 721
Score = 84.7 bits (208), Expect = 2e-16
Identities = 63/192 (32%), Positives = 101/192 (52%), Gaps = 8/192 (4%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G ++V L++ GA
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGA 558
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +A+ + + E++K LL GAN G T L A + G +
Sbjct: 559 DIELGCS----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVAD 614
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAAA 182
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D L + A
Sbjct: 615 VLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAG 674
Query: 183 QMGHTKILDLLI 194
GH +++LL+
Sbjct: 675 --GHLAVVELLL 684
Score = 77.0 bits (188), Expect = 3e-14
Identities = 51/152 (33%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA QG ++V +LL+ A+ TPL A G +V R+LL GA+VN
Sbjct: 1004 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1063
Query: 69 HSMCGWNS-LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 127
++ L A+ + + + +LL+ +GA+ + ++ G TPL++AA G L+ + +L+
Sbjct: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1123
Query: 128 SGANVNCQALDKATPLFIAAQEGHTKCVELLL 159
+GA+V+ K TPL A ++GH K V L+
Sbjct: 1124 AGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 72.0 bits (175), Expect = 1e-12
Identities = 70/264 (26%), Positives = 115/264 (43%), Gaps = 8/264 (3%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S+G V+ LL G N T E + L LA G ++ ++LL ANV
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L A+ + +I+KLLL A+ Q G T L A G ++ + +L+ SGA++
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL A GH + LLL +GA + + NE + + A GH +++
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRF 419
Query: 193 LIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQ 252
L+ + + A GH + +LL +G + A F SP+ +A
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLTLA-- 474
Query: 253 KDC-EFFGIVNILLKYGAQINELH 275
C + +L++ GA + E++
Sbjct: 475 -ACGGHVELAALLIERGASLEEVN 497
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/165 (27%), Positives = 79/165 (47%), Gaps = 4/165 (2%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T L +A G E + L+ GA++ + TPL +AA GH VE+LL +GAD +
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+E + P+ A G ++++LL+ ++ +P+ A GG+ + ++ILL
Sbjct: 894 Q-SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
G +++ G SP+ +A V +LL G+ IN
Sbjct: 953 NAGAEINSRTGSKLGI-SPLMLAAMNG--HTAAVKLLLDMGSDIN 994
Score = 53.9 bits (128), Expect = 3e-07
Identities = 74/303 (24%), Positives = 118/303 (38%), Gaps = 39/303 (12%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G AL A GH + +LL+AGAD + TPL A G + ++ L+ G
Sbjct: 594 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
ANVN + + L A + +++LLL GA+ + G T L AA+ G +
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 123 SILISSGANVNCQALDKATPLFIAAQE-GHTKCVEL----LLSSGADPDLYCNEDSWQLP 177
L+ N+ T L + + V + ++ +PD + LP
Sbjct: 714 CYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLP 773
Query: 178 IH------AAAQMGHTKILDLLIPLTNRACDTGLNKVS-----PVYSAV----------- 215
I A+ M +T + ++ T +S P+Y A+
Sbjct: 774 IRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHD 833
Query: 216 -------FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYG 268
GGHE+ ++ LL G S + + F +P+ +A G+V ILL G
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGF---TPLILA--ATAGHVGVVEILLDNG 888
Query: 269 AQI 271
A I
Sbjct: 889 ADI 891
Score = 46.2 bits (108), Expect = 6e-05
Identities = 27/68 (39%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G L LAA+ GH +VQ+L++AGAD +A + TPL A G + V+R L++ N
Sbjct: 1101 KGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VN 1159
Query: 65 VNGSHSMC 72
S S C
Sbjct: 1160 QFPSDSEC 1167
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 109 bits (272), Expect = 6e-24
Identities = 85/295 (28%), Positives = 129/295 (43%), Gaps = 38/295 (12%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T G+ L +AA + +LL GAD N + PL A +NG RLLL H
Sbjct: 391 QTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDH 450
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
GA V+ GW LH A+ + +LL+ + A+ + G TPL VAA +G +
Sbjct: 451 GACVDAQERE-GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD--------------- 166
+ +L S GA ++ Q + TPL +A + G + ++ LL SGA PD
Sbjct: 510 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAA 569
Query: 167 ----LYC-------------NEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 209
L C W P+H AA GH +I+ LL G +
Sbjct: 570 RGKYLICKMLLRYGASLELPTHQGW-TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
Query: 210 PVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 264
P++ A G E + LL+ G P+A + +P+ +A Q+ F ++N+L
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGW---TPLHLAVQRS-TFLSVINLL 679
Score = 99.0 bits (245), Expect = 8e-21
Identities = 74/222 (33%), Positives = 102/222 (45%), Gaps = 34/222 (15%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
EG LH+AA GH +V++L GA+ +A TPL LAVE G++ ++ LL+ GA
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA- 551
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
V + G+ LH A+ + I K+LLR GA+ E G TPL +AA G LE + +
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 125 LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ--------- 175
L S AN+ TPL +AA+ G V LL GADP+ + W
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAVQRS 670
Query: 176 -----------------------LPIHAAAQMGHTKILDLLI 194
P H AA G+T IL +L+
Sbjct: 671 TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
Score = 96.7 bits (239), Expect = 4e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 8/233 (3%)
Query: 39 ETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 98
+ TPL V G ++ +RLLL H +V+ + G+ L A+ + ++ LLL GA+
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVD-CQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 99 KECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 158
D+ G PL AAQ G + +L+ GA V+ Q + TPL +AAQ LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 159 LSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGG 218
+S ADP+L+ E + P+H AA GH ++ LL N +P++ AV G
Sbjct: 481 VSRQADPNLH--EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
Query: 219 HEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 271
++ LL++G PDA +G P+ A + + I +LL+YGA +
Sbjct: 539 KVRAIQHLLKSGAVPDALDQSGYG---PLHTAAARG--KYLICKMLLRYGASL 586
Score = 85.1 bits (209), Expect = 1e-16
Identities = 52/162 (32%), Positives = 86/162 (53%), Gaps = 1/162 (0%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G+ LH AA++G + I ++LL GA T + TPL LA G ++++ LL + AN+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
G+ W LH A+ ++ LL+ GA+ + G TPL +A Q S+ L
Sbjct: 620 -GALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
+ ANV+ + TP +AA +G+T +++L+ +GA D+
Sbjct: 679 LEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV 720
Score = 80.1 bits (196), Expect = 4e-15
Identities = 51/146 (34%), Positives = 76/146 (52%), Gaps = 1/146 (0%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+ T +G+ LHLAA +GH +I+ +L E+ A+ A TPL LA +G+ V+ LLQ
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA+ N + GW LH A + + LL AN ++ G TP +AA G
Sbjct: 648 CGADPNAA-EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706
Query: 121 SLSILISSGANVNCQALDKATPLFIA 146
L +L+ +GA ++ Q TPL +A
Sbjct: 707 ILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 77.8 bits (190), Expect = 2e-14
Identities = 46/116 (39%), Positives = 63/116 (54%), Gaps = 1/116 (0%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LHLAA G +V LL+ GADPNA TPL LAV+ + LL+H ANV+ +
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ GW H A+ + N I+K+L+ GA + QD TPL +A + K +S L
Sbjct: 690 KV-GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 74.7 bits (182), Expect = 2e-13
Identities = 69/231 (29%), Positives = 105/231 (45%), Gaps = 19/231 (8%)
Query: 77 LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQA 136
LH Q + E ++LLL + +CQ G TPL +AAQ + + ++L++ GA+ N
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425
Query: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196
D PL AAQ G LLL GA D + W P+H AAQ + LL+
Sbjct: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ-EREGW-TPLHLAAQNNFENVARLLV-- 481
Query: 197 TNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQK 253
+R D L++ +P++ A + GH +++L G DAQ +P+ +A ++
Sbjct: 482 -SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ---RNLRTPLHLAVER 537
Query: 254 DCEFFGIVNILLKYGAQINELH------LAYCLKYEKFSIFRYFLRKGCSL 298
+ LLK GA + L L K+ I + LR G SL
Sbjct: 538 G--KVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Score = 36.2 bits (82), Expect = 0.062
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 2/103 (1%)
Query: 134 CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 193
C +K TPL +G + V LLL+ D D C S P+ AAQ + LL
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVD--CQTASGYTPLLIAAQDQQPDLCALL 414
Query: 194 IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 236
+ A + +P++ A G + +LL +G DAQ
Sbjct: 415 LAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
Score = 33.5 bits (75), Expect = 0.40
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 58
G+ HLAA +G+ I+++L+EAGA + TPL LA+ + + ++ L
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 109 bits (272), Expect = 6e-24
Identities = 83/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K + + ALH AA G ++LLE A N E TP+ +A ++GQ +++R+LL+
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK-GANKECQDDFGITPLFVAAQYGKLE 120
G +V+ W LH A++Q + I+KLL ++ G + Q G TPL +AAQ G
Sbjct: 560 GVDVS-LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYR 618
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
ILI ++VN +L TPL +AA+ GHT LLL GA + ++ +H
Sbjct: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG--YTALHL 676
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
AA+ GH + LL+ G + ++ A GH + +E L+ A +
Sbjct: 677 AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV------SADVIDL 730
Query: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
F + V LL++GA IN
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 105 bits (261), Expect = 1e-22
Identities = 76/232 (32%), Positives = 111/232 (47%), Gaps = 6/232 (2%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LHLA G + + LL A+PN + +TPL +AVE V+ LLL +V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N W +LH A+ + +LLL K A+ D G TP+ VA Q+G+ + IL
Sbjct: 498 NAKDED-QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDS--WQLPIHAAAQ 183
+ G +V+ Q D PL AA +GH V+LL P + N + + P+H AAQ
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL---AKQPGVSVNAQTLDGRTPLHLAAQ 613
Query: 184 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
GH ++ +LI L + L +P++ A GH +LL G +A
Sbjct: 614 RGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665
Score = 82.4 bits (202), Expect = 8e-16
Identities = 55/166 (33%), Positives = 87/166 (52%), Gaps = 2/166 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T +G LHLAA +GH+++ +IL++ +D N +L TPL +A E G RLLL
Sbjct: 600 QTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHR 659
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
GA S G+ +LH A+ + +KLL+ + A+ + T L +AA +G E
Sbjct: 660 GAGKEAMTS-DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEV 718
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
+ L+S+ ++ + L +AAQ H + VE LL GA +L
Sbjct: 719 VEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/133 (29%), Positives = 59/133 (44%), Gaps = 2/133 (1%)
Query: 104 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 163
D G + L +A + G+ E L+ + AN N +TPL +A + VELLL+
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 164 DPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL 223
+ +ED W +H AAQ G LL+ + +P++ A G E+ +
Sbjct: 496 SVNAK-DEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553
Query: 224 EILLRNGYSPDAQ 236
ILLR G Q
Sbjct: 554 RILLRRGVDVSLQ 566
Score = 28.9 bits (63), Expect = 9.9
Identities = 15/34 (44%), Positives = 20/34 (58%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE 38
+G ALHLAA H + V+ LL GA N +L+
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 107 bits (268), Expect = 2e-23
Identities = 81/258 (31%), Positives = 120/258 (46%), Gaps = 35/258 (13%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALH A GH + V +LL GA N +E PL A G ++VL+LL+ GA++
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
G G+ LH A+ E++K LLR GA + + FG T L +A G+ L
Sbjct: 200 -GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIEL 258
Query: 126 ISSGANVNCQALDKA-TPLFIAA-QEGHTKCVELLLSSGAD------------------- 164
+++GANVN Q DK TPL +AA C+ELL+++GAD
Sbjct: 259 VNAGANVN-QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
Query: 165 ------------PDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 212
++ C + P+H AA+ GH ++ L+ G++ + P++
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377
Query: 213 SAVFGGHEDCLEILLRNG 230
AV G DC LL +G
Sbjct: 378 LAVLFGFSDCCRKLLSSG 395
Score = 105 bits (261), Expect = 1e-22
Identities = 70/227 (30%), Positives = 110/227 (48%), Gaps = 9/227 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LHLAA GH + ++ L E + + + T LFLA E G + + +L HGA+
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN---KECQDDFGITPLFVAAQYGKLESLSILI 126
W LH A+ + + + LL+ G + D +G TPL +A G ++ + +L+
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 127 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
G+ + L T L A G C+ LL D + C + + PIH A+ GH
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH--DAFVLCRDFKGRTPIHLASACGH 766
Query: 187 TKILDLLI--PLTNRACDTGL--NKVSPVYSAVFGGHEDCLEILLRN 229
T +L L+ L+ D G+ + SP++ A + GHEDCLE+LL +
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 96.3 bits (238), Expect = 5e-20
Identities = 76/263 (28%), Positives = 119/263 (45%), Gaps = 35/263 (13%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGAD----------------------------PNATTL 37
G LH AA+ G ++ L+ AGA P++
Sbjct: 456 GRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDA 515
Query: 38 EETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA 97
EE PL + L LL +GA+ + G+ ++H A+ N + ++LLL
Sbjct: 516 EEDEPLKESRRKEAFFCLEFLLDNGADPS-LRDRQGYTAVHYAAAYGNRQNLELLLEMSF 574
Query: 98 N--KECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCV 155
N ++ + ++PL +AA G E+L L + N++ + T LF+A + G T+CV
Sbjct: 575 NCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECV 634
Query: 156 ELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV---SPVY 212
E+L + GA + + W P+HAAA GHT L LLI RA T + +P+
Sbjct: 635 EVLTAHGASALIKERKRKW-TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM 693
Query: 213 SAVFGGHEDCLEILLRNGYSPDA 235
A+ GH DC+ +LL G + DA
Sbjct: 694 LAIMNGHVDCVHLLLEKGSTADA 716
Score = 95.1 bits (235), Expect = 1e-19
Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 22/248 (8%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K +G+ LH AA+ G ++V+ LL GA+ + T L +A GQ V L+
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEI-IKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GANVN + G+ LH A+ N + ++LL+ GA+ Q G +PL +AA +G+
Sbjct: 262 GANVNQPNDK-GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFT 320
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
ILI +G+ ++C TPL +AA+ GH + L+++GAD D P+H
Sbjct: 321 RSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHD--MFPLHL 378
Query: 181 AAQMGHT----------KILDLLIPLTN-RACDTGLNKVSP-------VYSAVFGGHEDC 222
A G + ++ ++ L+N G + +P +++A GG+ +C
Sbjct: 379 AVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVEC 438
Query: 223 LEILLRNG 230
L +LL +G
Sbjct: 439 LNLLLSSG 446
Score = 90.9 bits (224), Expect = 2e-18
Identities = 79/268 (29%), Positives = 115/268 (42%), Gaps = 49/268 (18%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG--- 62
G LH+AA GH ++ L+ GAD + + PL LAV G D R LL G
Sbjct: 339 GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLY 398
Query: 63 ---ANVNGSHSMC-----------GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGIT 108
++++ H + G LH A+ N E + LLL GA+ +D FG T
Sbjct: 399 SIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRT 458
Query: 109 PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAA-------QEGHTK-------- 153
PL AA G + L+++GA VN +PL AA E HT
Sbjct: 459 PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEED 518
Query: 154 -------------CVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA 200
C+E LL +GADP L + +H AA G+ + L+LL+ ++
Sbjct: 519 EPLKESRRKEAFFCLEFLLDNGADPSL--RDRQGYTAVHYAAAYGNRQNLELLLEMSFNC 576
Query: 201 CD--TGLNKVSPVYSAVFGGHEDCLEIL 226
+ VSP++ A + GH + L+ L
Sbjct: 577 LEDVESTIPVSPLHLAAYNGHCEALKTL 604
Score = 86.7 bits (213), Expect = 4e-17
Identities = 74/251 (29%), Positives = 116/251 (46%), Gaps = 20/251 (7%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV--ENGQIDVLRLLLQHGA 63
G ALH+A G + L+ AGA+ N + TPL +A NG + L LL+ +GA
Sbjct: 239 GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGA 297
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
+VN S G + LH A+ ++L++ G+ +C D FG TPL VAA+YG +S
Sbjct: 298 DVN-YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIS 356
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG----------------ADPDL 167
L+++GA+ + + PL +A G + C LLSSG A D+
Sbjct: 357 TLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
++ + +HAAA G+ + L+LL+ +P++ A G C L+
Sbjct: 417 NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
Query: 228 RNGYSPDAQAC 238
G + C
Sbjct: 477 TAGAGVNEADC 487
Score = 85.5 bits (210), Expect = 9e-17
Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 11/217 (5%)
Query: 22 VQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGW-NSLHQA 80
V+ LL + N E TPL A G + +L+LLL GANVN ++ W LH+A
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTL--WLTPLHRA 81
Query: 81 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA 140
+ N +++ LLL A+ +D TPL VAA + L +++N
Sbjct: 82 AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141
Query: 141 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRA 200
+ L A GH + V LLL+ GA ++ C++ Q P+H AA +GH ++L LL+ R
Sbjct: 142 SALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQ-PLHWAAFLGHLEVLKLLVA---RG 196
Query: 201 CDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPD 234
D G +++A G + ++ LLR G D
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233
Score = 80.5 bits (197), Expect = 3e-15
Identities = 59/196 (30%), Positives = 95/196 (48%), Gaps = 8/196 (4%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLLLQH 61
+ G+ +H A+ GH +++LLE + LE TPL AV N Q +LL
Sbjct: 789 YSGYSPMHWASYTGHEDCLELLLEHSP---FSYLEGNPFTPLHCAVINNQDSTTEMLLGA 845
Query: 62 -GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GA + S G LH A+F +N +++LL+ A D G T L AA+ G+
Sbjct: 846 LGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTA 905
Query: 121 SLSILISSG-ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY-CNEDSWQLPI 178
++ L+ G A++ +K T L +A +GH KC ++L+ D L + Q+P+
Sbjct: 906 AVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPL 965
Query: 179 HAAAQMGHTKILDLLI 194
H AA+ G ++ L+
Sbjct: 966 HIAARNGLASVVQALL 981
Score = 79.7 bits (195), Expect = 5e-15
Identities = 74/265 (27%), Positives = 123/265 (46%), Gaps = 26/265 (9%)
Query: 36 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 95
++ + PL A+ + ++ +R LL N+N LH A++ + I++LLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMS 63
Query: 96 GANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCV 155
GAN +D +TPL AA + L +L++ A+VN + TPL +AA TKC
Sbjct: 64 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123
Query: 156 EL---LLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI--PLTNRACDTGLNKVSP 210
E LLSS L + S + +H A GH + ++LL+ + CD + P
Sbjct: 124 EALAPLLSS-----LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK--KERQP 176
Query: 211 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 270
++ A F GH + L++L+ G + +G + Q + +V LL+ GA+
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE-----VVKYLLRMGAE 231
Query: 271 INE--------LHLAYCLKYEKFSI 287
I+E LH+A L + +I
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAI 256
Score = 78.6 bits (192), Expect = 1e-14
Identities = 60/186 (32%), Positives = 94/186 (50%), Gaps = 5/186 (2%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LH AA G I+Q+LL +GA+ NA TPL A + VL LLL H A+VN
Sbjct: 45 LHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARD 104
Query: 70 SMCGWNS-LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
+ W + LH A+ + + L ++ D G + L A G LE++++L++
Sbjct: 105 KL--WQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA++N + PL AA GH + ++LL++ GA DL C + +H AA G +
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGA--DLGCKDRKGYGLLHTAAASGQIE 220
Query: 189 ILDLLI 194
++ L+
Sbjct: 221 VVKYLL 226
Score = 53.1 bits (126), Expect = 5e-07
Identities = 58/229 (25%), Positives = 91/229 (39%), Gaps = 6/229 (2%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G L LA GH V +LLE G+ +A L T L G D L LL H A V
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD---DF-GITPLFVAAQYGKLES 121
G +H AS + +++ LL+ + + D D+ G +P+ A+ G +
Sbjct: 748 L-CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
L +L+ + + TPL A E+LL + + + + P+HAA
Sbjct: 807 LELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAA 865
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
A + L +L+ T + + +A G +E LL G
Sbjct: 866 AFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Score = 43.9 bits (102), Expect = 3e-04
Identities = 47/166 (28%), Positives = 68/166 (40%), Gaps = 14/166 (8%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA- 63
+G LH AA + +++LL+ A+ NAT T L A ENGQ + LL G
Sbjct: 857 KGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKA 916
Query: 64 -------NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQY 116
N N + + + + AE L L N Q PL +AA+
Sbjct: 917 DLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQ-----MPLHIAARN 971
Query: 117 GKLESLSILISSGANVNCQALDKATP-LFIAAQEGHTKCVELLLSS 161
G + L+S GA V + TP L A + C+ L+LS+
Sbjct: 972 GLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILST 1017
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 106 bits (264), Expect = 5e-23
Identities = 77/261 (29%), Positives = 117/261 (44%), Gaps = 33/261 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G ALH AA GH ++V +LL GA+ NA ++ L A G +DV+ LL+ HGA V
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
G+ LH A+ ++K LL G + + +G T L +A G+ ++ L
Sbjct: 175 TCKDKK-GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Query: 126 ISSGANVNCQALDKATPLFIAAQEGH-TKCVELLLSSGADPDLY---------------- 168
I GANVN + TPL AA H C+ELL+++GAD ++
Sbjct: 234 IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Query: 169 ---------------CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYS 213
C + P+H AA+ GH +++ L G++ + P++
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353
Query: 214 AVFGGHEDCLEILLRNGYSPD 234
A H DC LL +G+ D
Sbjct: 354 AALNAHSDCCRKLLSSGFEID 374
Score = 100 bits (250), Expect = 2e-21
Identities = 78/276 (28%), Positives = 130/276 (47%), Gaps = 15/276 (5%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K +G+ LH AAS G +V+ LL G + + + T L +A NGQ V+ L+ +
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEI-IKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
GANVN ++ G+ LH A+ + + ++LL+ GA+ Q G +PL + A +G+
Sbjct: 237 GANVNQPNNN-GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFT 295
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
LI +G ++C D TPL +AA+ GH + L +SGAD C S P+H
Sbjct: 296 RSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS-MFPLHL 353
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---YSPDAQA 237
AA H+ L+ + +++A GG+ +C+++L +G + D
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 238 CLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE 273
+++ C F + L+ GA +NE
Sbjct: 414 RTPLHYAAANC--------HFHCIETLVTTGANVNE 441
Score = 100 bits (248), Expect = 3e-21
Identities = 64/224 (28%), Positives = 111/224 (49%), Gaps = 8/224 (3%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LHLAA GH + +++LL++ D + + T L LA G + + L+ GA++
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKEC---QDDFGITPLFVAAQYGKLESLSILI 126
++ LH + + ++LLL N E +D G TPL +A YG ++++S+L+
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 127 SSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
ANV+ + T L GH +CV++LL + + C + + P+H AA GH
Sbjct: 666 EKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGH 723
Query: 187 TKILDLLIPLT---NRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
L L+ + C +P++ A + G+E+C+E+LL
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 90.9 bits (224), Expect = 2e-18
Identities = 71/232 (30%), Positives = 109/232 (46%), Gaps = 10/232 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LH A + + VQ+L++ AD NA TPL +A N + +++ ++VN S
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS- 111
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
G +LH A+ + E++ LLL KGAN D L AA G L+ +++LI+ G
Sbjct: 112 DRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD---LYCNEDSWQLPIHAAAQMGH 186
A V C+ TPL AA G V+ LL+ G + D +Y N +H A G
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGN-----TALHIACYNGQ 226
Query: 187 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHED-CLEILLRNGYSPDAQA 237
+++ LI N +P++ A H CLE+L+ NG + Q+
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Score = 90.5 bits (223), Expect = 3e-18
Identities = 71/223 (31%), Positives = 109/223 (48%), Gaps = 12/223 (5%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LHLAA H + LL +G + + T L A G ++ ++LL GA+ +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH-KK 409
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
CG LH A+ + I+ L+ GAN DD+G T L AA + +IL
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL--GN 467
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 189
A+ N + L++A L ++ T C+E LL + A+P + + IH AA GH +
Sbjct: 468 AHDNSEELERAREL---KEKEATLCLEFLLQNDANPSI--RDKEGYNSIHYAAAYGHRQC 522
Query: 190 LDLLIPLTN---RACDTGLNKVSPVYSAVFGGHEDCLEILLRN 229
L+LL+ TN D+G K SP++ A + GH LE+LL++
Sbjct: 523 LELLLERTNSGFEESDSGATK-SPLHLAAYNGHHQALEVLLQS 564
Score = 90.5 bits (223), Expect = 3e-18
Identities = 70/229 (30%), Positives = 111/229 (48%), Gaps = 14/229 (6%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEET---TPLFLAVENGQIDVLRLLLQHGANVN 66
LH + GH +++LLE +P A +++ TPL LAV G ID + LLL+ ANV+
Sbjct: 613 LHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD 672
Query: 67 GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 126
+ + G +LH+ + E +++LL + + C+D G TPL AA G LS L+
Sbjct: 673 -TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELL 731
Query: 127 SSG-ANVNCQALDKA--TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 183
+ +C D TPL A G+ C+E+LL N + P+H A
Sbjct: 732 QMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFT---PLHCAII 788
Query: 184 MGHTKILDLLIPLTNRA---CDTGLNKVSPVYSAVFGGHEDCLEILLRN 229
H LL+ + + C + +P+ +A F H +CL++LLR+
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGR-TPLRAAAFADHVECLQLLLRH 836
Score = 85.9 bits (211), Expect = 7e-17
Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 38/306 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G LH AA+ G+ + +++L +GAD + TPL A N + L+ GANV
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 66 NGSHSMCGWNSLHQASFQE-------------NAE---------------IIKLLLRKGA 97
N + G +LH A+ + N+E ++ LL+ A
Sbjct: 440 NETDDW-GRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDA 498
Query: 98 NKECQDDFGITPLFVAAQYGKLESLSILI---SSGANVNCQALDKATPLFIAAQEGHTKC 154
N +D G + AA YG + L +L+ +SG + K+ PL +AA GH +
Sbjct: 499 NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQA 557
Query: 155 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI-PLTNRACDTGLNKVSPVYS 213
+E+LL S D D+ ++ + + AA GHT+ ++ LI P + + K +P+++
Sbjct: 558 LEVLLQSLVDLDI--RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
Query: 214 AVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE 273
+V GH CL +LL +P+A +P+ +A V++LL+ A ++
Sbjct: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYG--HIDAVSLLLEKEANVDT 673
Query: 274 LHLAYC 279
+ + C
Sbjct: 674 VDILGC 679
Score = 78.6 bits (192), Expect = 1e-14
Identities = 57/214 (26%), Positives = 103/214 (48%), Gaps = 3/214 (1%)
Query: 22 VQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH-GANVNGSHSMCGWNSLHQA 80
++ LL+ A+P+ E + A G L LLL+ + S S + LH A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 81 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQA-LDK 139
++ + + +++LL+ + + +D+ G T L +AA G E + LI+ GA++ + + K
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Query: 140 ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDS-WQLPIHAAAQMGHTKILDLLIPLTN 198
TPL + GHT C+ LLL +P+ +D+ Q P+ A GH + LL+
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 199 RACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYS 232
+ + ++ + GHE+C+++LL S
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Score = 71.2 bits (173), Expect = 2e-12
Identities = 62/230 (26%), Positives = 101/230 (43%), Gaps = 40/230 (17%)
Query: 77 LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQA 136
LH A+F +AEII+LL+ GA +D+ +TPL A E++ +LI A+VN +
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 137 LDKATPLFIAAQ---------------------------------EGHTKCVELLLSSGA 163
+ TPL +AA GH + V LLL+ GA
Sbjct: 80 KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA 139
Query: 164 DPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL 223
+ + + +D + +H AA MGH ++ LLI +P+++A G + +
Sbjct: 140 NINAFDKKD--RRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197
Query: 224 EILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE 273
+ LL G D V+G ++ + +VN L+ YGA +N+
Sbjct: 198 KHLLNLGVEID--EINVYGNTALHIACYNGQ---DAVVNELIDYGANVNQ 242
Score = 68.6 bits (166), Expect = 1e-11
Identities = 55/171 (32%), Positives = 84/171 (49%), Gaps = 9/171 (5%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
K +G+ LH A G+ +++LLE TPL A+ N + LLL
Sbjct: 743 KDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLL-- 799
Query: 62 GANVNGSHSMC----GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 117
GA ++ S C G L A+F ++ E ++LLLR A D+ G T L +AA+ G
Sbjct: 800 GA-IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENG 858
Query: 118 KLESLSILISSG-ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
+ ++ IL++S A++ + D TPL +A +GH KC L+L D L
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESL 909
Score = 67.4 bits (163), Expect = 2e-11
Identities = 58/200 (29%), Positives = 86/200 (43%), Gaps = 12/200 (6%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET---TPLFLAVENGQIDVLRLL 58
K G LH AA++GH + LL+ ++ TPL A NG + + +L
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Query: 59 LQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRK--GANKECQDDFGITPLFVAA 114
L+ G + LH A ++ LLL + C+DD G TPL AA
Sbjct: 767 LEQKC----FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822
Query: 115 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 174
+E L +L+ A VN T L +AA+ G V++L++S A DL +
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS-AQADLTVKDKDL 881
Query: 175 QLPIHAAAQMGHTKILDLLI 194
P+H A GH K L++
Sbjct: 882 NTPLHLACSKGHEKCALLIL 901
Score = 65.9 bits (159), Expect = 7e-11
Identities = 48/181 (26%), Positives = 83/181 (45%), Gaps = 7/181 (3%)
Query: 91 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 150
+L+ K + D TPL VAA G E + +LI SGA VN + TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 151 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 210
+ V++L+ A D+ + +WQ P+H AA K +++IPL + + +
Sbjct: 61 SEEAVQVLIKHSA--DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 211 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 270
++ A GH + + +LL G + +A F + + +V +L+ +GA+
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINA-----FDKKDRRALHWAAYMGHLDVVALLINHGAE 173
Query: 271 I 271
+
Sbjct: 174 V 174
Score = 63.9 bits (154), Expect = 3e-10
Identities = 53/197 (26%), Positives = 88/197 (44%), Gaps = 5/197 (2%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+K +G L LA + GH V +LLE A+ + + T L + G + +++LL+
Sbjct: 640 VKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE---CQDDFGITPLFVAAQYG 117
++ S G LH A+ + +A + LL+ ++E +D+ G TPL A G
Sbjct: 700 QEVSILCKDSR-GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNG 758
Query: 118 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 177
+ +L+ + TPL A H C LLL + + C +D + P
Sbjct: 759 NENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
Query: 178 IHAAAQMGHTKILDLLI 194
+ AAA H + L LL+
Sbjct: 818 LRAAAFADHVECLQLLL 834
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 105 bits (261), Expect = 1e-22
Identities = 78/228 (34%), Positives = 117/228 (51%), Gaps = 4/228 (1%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G L +AA GH V+ L+ GAD N TT LF A + G DV+R L GA+
Sbjct: 46 GTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAST 105
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ G +L AS + ++++ LL+ GAN Q G T LF+AAQ G L+ + +L
Sbjct: 106 E-FRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLL 164
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
++SGA VN D PL+IA+Q GH++ V ++L GAD D N+ + L AA G
Sbjct: 165 LASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL--LKAANKG 222
Query: 186 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 233
+ ++ L+ + N S +++AV G+ + +LL G P
Sbjct: 223 YNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADP 269
Score = 84.0 bits (206), Expect = 3e-16
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 37/224 (16%)
Query: 13 AASQGHWKIVQILLEAG-ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 71
AA +G+ ++++LL +G D + TT L +A G ID +R L+ GA++N
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 72 CGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN 131
G +L A+ Q + ++++ L GA+ E + G T L A+QYG ++ + L+ GAN
Sbjct: 79 -GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
Query: 132 VNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILD 191
++ Q D AT LF+AAQ G+ + LLL+SGA + + + P+ A+QMGH+++
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT--APLWIASQMGHSEV-- 193
Query: 192 LLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
+ ++L G DA
Sbjct: 194 -------------------------------VRVMLLRGADRDA 206
Score = 83.6 bits (205), Expect = 3e-16
Identities = 56/166 (33%), Positives = 89/166 (53%), Gaps = 2/166 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T +G AL A+ GH ++V+ LL+ GA+ + + T LFLA + G +DV+RLLL
Sbjct: 108 RTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLAS 167
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
GA VN G L AS ++E+++++L +GA+++ + G T L AA G +
Sbjct: 168 GAKVN-QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDV 226
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
+ L+ + + + L A G+ K V LLL +GADP L
Sbjct: 227 IKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLEAGADPSL 271
Score = 77.8 bits (190), Expect = 2e-14
Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 3/157 (1%)
Query: 75 NSLHQASFQENAEIIKLLLRKG-ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN 133
N+ A+ + N ++KLLL G + +C+D G T L VAA G ++ + L+ GA++N
Sbjct: 14 NAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADIN 73
Query: 134 CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 193
Q T LF AAQ+GH V L GA + + L AA+Q GH ++++ L
Sbjct: 74 LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTAL--LAASQYGHMQVVETL 131
Query: 194 IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
+ D + + ++ A GG+ D + +LL +G
Sbjct: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASG 168
Score = 34.3 bits (77), Expect = 0.23
Identities = 20/51 (39%), Positives = 25/51 (49%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 56
G ALH A G+ K V +LLEAGADP+ P L + +LR
Sbjct: 243 GTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 105 bits (261), Expect = 1e-22
Identities = 73/195 (37%), Positives = 104/195 (53%), Gaps = 8/195 (4%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G+ AL AA GH ++V LL AG + + T L A G D++ LLQHGA
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVA-----AQYGKL 119
VN + + G +L A++ + EI++ LL GA +D G T L VA A G
Sbjct: 670 VNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 120 ESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIH 179
+S+LI GA V+ D TPL +AA EGH V+LLL GAD D +++ + P+
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD--HTDNNGRTPLL 786
Query: 180 AAAQMGHTKILDLLI 194
AAA MGH +++ L+
Sbjct: 787 AAASMGHASVVNTLL 801
Score = 103 bits (258), Expect = 2e-22
Identities = 84/298 (28%), Positives = 135/298 (45%), Gaps = 37/298 (12%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G L AAS GH +V LL GA ++ E T L +A G ++V+R LL G +
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N GW LH A+F+ + I + L+ +GA D+ G P +A+Q G + + IL
Sbjct: 841 NHRDD-AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD---------PDLY-------- 168
+ + +N++ + D L +AA EGH VELL S GAD P LY
Sbjct: 900 LENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
Query: 169 --------------CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA 214
++ + +H + GH +++ +LI K S + SA
Sbjct: 960 TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
Query: 215 VFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+ GH +++L+ +G D C ++ +C+A Q+ +V +LL++GA N
Sbjct: 1020 AWQGHVKVVQLLIEHGAVVD-HTC--NQGATALCIAAQEG--HIDVVQVLLEHGADPN 1072
Score = 99.8 bits (247), Expect = 5e-21
Identities = 96/332 (28%), Positives = 140/332 (42%), Gaps = 48/332 (14%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL AA GH IV LL+ GA+ N E T L A G +++ LL HGA VN
Sbjct: 647 ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-H 705
Query: 69 HSMCGWNSLHQASF-----QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
+ G +L A+ + +A ++ LL+ +GA + D G+TPL VAA G ++ +
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNE------------ 171
+L+ GA+V+ + TPL AA GH V LL GA D +E
Sbjct: 766 LLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQG 825
Query: 172 -------------------DSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 212
D+ P+H AA GH I + LI R + + P
Sbjct: 826 NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI 885
Query: 213 SAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
A GH DC++ILL N + D + G+ + IV +L +GA +N
Sbjct: 886 LASQEGHYDCVQILLENKSNIDQR-----GYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 273 -----ELHLAYCLKYE-KFSIFRYFLRKGCSL 298
Y L E + ++ YFL G ++
Sbjct: 941 CKDADGRPTLYILALENQLTMAEYFLENGANV 972
Score = 98.2 bits (243), Expect = 1e-20
Identities = 77/235 (32%), Positives = 115/235 (48%), Gaps = 8/235 (3%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G L LAA QGH K+V L+ GA+ N T + T L A G +V+ LL G V
Sbjct: 578 GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV 637
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
+ + + +L A++ + +I+ LL+ GA D+ G T L AA G E + L
Sbjct: 638 DCADA-DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Query: 126 ISSGANVNCQALDKATPLFIA-----AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
+ GA VN + +D T L +A A +GH V LL+ GA+ D +C++D P+
Sbjct: 697 LDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDG-MTPLLV 754
Query: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 235
AA GH ++DLL+ T N +P+ +A GH + LL G + D+
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/229 (30%), Positives = 116/229 (50%), Gaps = 3/229 (1%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
+T AL + AS+GH +V +L++ GA+ + + TPL +A G +DV+ LLL+
Sbjct: 711 RTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 770
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
GA+V+ + + G L A+ +A ++ LL GA + D G T L +A+ G +E
Sbjct: 771 GADVDHTDNN-GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
Query: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
+ L+ G + N + TPL +AA EGH E L+ GA + N+ ++P A
Sbjct: 830 VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG--RIPFILA 887
Query: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
+Q GH + +L+ + G + + + A GH D +E+L +G
Sbjct: 888 SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
Score = 96.3 bits (238), Expect = 5e-20
Identities = 64/191 (33%), Positives = 106/191 (55%), Gaps = 5/191 (2%)
Query: 4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 63
++G AL +AA +GH IV++L GAD N + L++ Q+ + L++GA
Sbjct: 911 YDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGA 970
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
NV S + G +LH + +Q + E++++L+ A+ D+ + L AA G ++ +
Sbjct: 971 NVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQ 1029
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW-QLPIHAAA 182
+LI GA V+ AT L IAAQEGH V++LL GADP+ + D + + + AA
Sbjct: 1030 LLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN---HADQFGRTAMRVAA 1086
Query: 183 QMGHTKILDLL 193
+ GH++I+ LL
Sbjct: 1087 KNGHSQIIKLL 1097
Score = 94.7 bits (234), Expect = 1e-19
Identities = 69/225 (30%), Positives = 102/225 (45%), Gaps = 4/225 (1%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
AA G +V +L+ GAD TPL LA G V+ L+ GAN+N +
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHT-DQD 610
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
GW +L A++ + E++ LL G +C D T L AA G + + L+ GA V
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA---AAQMGHTKI 189
N + T L AA GH + VE LL GA+ + + L + A A GH +
Sbjct: 671 NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730
Query: 190 LDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
+ LLI + ++P+ A + GH D +++LL G D
Sbjct: 731 VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Score = 89.7 bits (221), Expect = 5e-18
Identities = 69/214 (32%), Positives = 115/214 (53%), Gaps = 11/214 (5%)
Query: 20 KIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQ 79
+++Q+L++AGA N+ ++ T + + D +R LL +GA+VN S G L
Sbjct: 495 EVLQLLVKAGAHVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSN-GRTLLAN 551
Query: 80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK 139
A++ + +++ LL+ +GA+ E +D G TPL +AA+ G + ++ LI GAN+N D
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 140 ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI---PL 196
T L AA GHT+ V LL +G D C + + + AAA GH I+ L+
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVD--CADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 197 TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
N+A + G + + +A + GH + +E LL +G
Sbjct: 670 VNKADNEGR---TALIAAAYMGHREIVEHLLDHG 700
Score = 73.2 bits (178), Expect = 5e-13
Identities = 44/127 (34%), Positives = 76/127 (59%), Gaps = 1/127 (0%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
EG ALH++ QGH ++VQ+L+ AD NA E+ + L A G + V++LL++HGA
Sbjct: 978 EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
V+ + + G +L A+ + + +++++LL GA+ D FG T + VAA+ G + + +
Sbjct: 1038 VDHTCNQ-GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 1096
Query: 125 LISSGAN 131
L GA+
Sbjct: 1097 LEKYGAS 1103
Score = 52.0 bits (123), Expect = 1e-06
Identities = 30/91 (32%), Positives = 50/91 (54%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G AL +AA +GH +VQ+LLE GADPN T + +A +NG +++LL ++GA+
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRK 95
S +++ Q Q + ++ L K
Sbjct: 1104 SLNGCSPSPVHTMEQKPLQSLSSKVQSLTIK 1134
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 103 bits (257), Expect = 3e-22
Identities = 76/236 (32%), Positives = 128/236 (54%), Gaps = 19/236 (8%)
Query: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
++ + + AL A+ +GH IV+ LL+ G + + T L A G+ DV+ LLL
Sbjct: 66 LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLS 125
Query: 61 HGAN--VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 118
HGAN V G +S+ + A+ + +A+I+ LLL+ GA C D +G TPL AA+ G
Sbjct: 126 HGANPSVTGLYSVY---PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
Query: 119 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPI 178
LE + L++ GA+V+ + + T L +A + G+T+ V+ +L +P++ + +
Sbjct: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK--RNPNVNLTDKDGNTAL 240
Query: 179 HAAAQMGHTKIL-DLL-----IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 228
A++ GHT+I+ DLL + + +R+ DT L AV GGH + + LL+
Sbjct: 241 MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVL------IGAVRGGHVEIVRALLQ 290
Score = 95.9 bits (237), Expect = 7e-20
Identities = 66/209 (31%), Positives = 108/209 (51%), Gaps = 4/209 (1%)
Query: 22 VQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQAS 81
++ LLE D + TPL +A E G +++++ L+++GAN N + W +L AS
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN-LEDLDNWTALISAS 79
Query: 82 FQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKAT 141
+ + I++ LL+ G N E +D G T L A G+ + + +L+S GAN + L
Sbjct: 80 KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
Query: 142 PLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC 201
P+ AA GH V LLL +GA + C++ P+ AA+ GH + + L+ +
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
Query: 202 DTGLNKVSPVYSAVFGGH-EDCLEILLRN 229
G N ++ + AV GG+ + EIL RN
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRN 226
Score = 84.0 bits (206), Expect = 3e-16
Identities = 53/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 83 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 142
+EN +K LL K + + +++ G TPL +AA+ G LE + LI +GAN N + LD T
Sbjct: 15 EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
Query: 143 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 202
L A++EGH VE LL G + + + + W + A G T +++LL+
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLE-HRDMGGW-TALMWACYKGRTDVVELLLSHGANPSV 132
Query: 203 TGLNKVSPVYSAVFGGHEDCLEILLRNG 230
TGL V P+ A GH D + +LL+NG
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNG 160
Score = 75.5 bits (184), Expect = 9e-14
Identities = 60/190 (31%), Positives = 92/190 (48%), Gaps = 3/190 (1%)
Query: 47 VENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFG 106
VE I L+ LL+ +V+ + CG L A+ Q N EI+K L++ GAN +D
Sbjct: 13 VEEENIPALKALLEKCKDVD-ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN 71
Query: 107 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 166
T L A++ G + + L+ G N+ + + T L A +G T VELLLS GA+P
Sbjct: 72 WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131
Query: 167 LYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 226
+ + PI AA GH I+ LL+ + + +P+ A GH +C++ L
Sbjct: 132 VTGLYSVY--PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHL 189
Query: 227 LRNGYSPDAQ 236
L G D +
Sbjct: 190 LAMGADVDQE 199
Score = 71.6 bits (174), Expect = 1e-12
Identities = 51/160 (31%), Positives = 81/160 (50%), Gaps = 1/160 (0%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
+G AL +A+ +GH +IVQ LL+AG N T L AV G ++++R LLQ A+
Sbjct: 235 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 294
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
++ +L+ A + NA +++ +L+ + E G TPL A + +E + +
Sbjct: 295 ID-IRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVEL 353
Query: 125 LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 164
L+ GA V+ TPL IA + K ELLL + D
Sbjct: 354 LLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 29.3 bits (64), Expect = 7.5
Identities = 17/59 (28%), Positives = 31/59 (52%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
T +G L A + ++V++LL+ GA +A + TPL +A+ + LLL++
Sbjct: 332 TKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 102 bits (254), Expect = 7e-22
Identities = 85/266 (31%), Positives = 125/266 (46%), Gaps = 39/266 (14%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT E AL A GH ++ ++LL++GA N +PL LA G +++ LL++
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD------------------ 103
GAN+ + G+ L +A+ + + E++ LLL +GAN Q
Sbjct: 461 GANLEEVNDE-GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
Query: 104 --DFGI-----------TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 150
DF I TPL A+Q G LE + L++SGANV+ T L A + G
Sbjct: 520 VADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Query: 151 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL---TNRACDTGLNK 207
HT ++LL +GA DL + + P+ AA+ GH + LI NRA T N
Sbjct: 580 HTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA--TANND 635
Query: 208 VSPVYSAVFGGHEDCLEILLRNGYSP 233
+ V A GGH +E+LL +G P
Sbjct: 636 HTVVSLACAGGHLAVVELLLAHGADP 661
Score = 100 bits (250), Expect = 2e-21
Identities = 75/230 (32%), Positives = 111/230 (48%), Gaps = 39/230 (16%)
Query: 7 FCALHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLLLQHGAN 64
+ L LAAS G+ I++ILL AGA+ N+ T + +PL LA NG + ++LLL G++
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
+N +L A FQ AE++ LLL + AN E + G+TPL AA G E +
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 125 LISSGANVNCQ------------ALDKA-----------------------TPLFIAAQE 149
L+ GA+VN A DK TPL++A+
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR 199
GH V+LL+ +GAD D N P+ +A + GH K++ L+ N+
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKI--TPLMSAFRKGHVKVVQYLVKEVNQ 1383
Score = 100 bits (248), Expect = 3e-21
Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G IV++LL GA+ TPL A G ++V R+LL HGA +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + ++++ LL GA++E + D T L A G +E +L
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA +L D P+ AA+ G
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREG 482
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 483 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ADIELGCS 536
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 537 TPLMEASQEG--HLELVKYLLASGANVH 562
Score = 97.8 bits (242), Expect = 2e-20
Identities = 73/266 (27%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA + GH ++V +L+ A + TPL LA G + V+ +LL G ++
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
L A E++ LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 129 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
GA +N + K +PL +AA GH V+LLL G+D + E + + A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1236
Query: 187 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSP 246
+++ LL+ ++P+ A GG+ + +LL G +A S
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP---VPSSRD 1293
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQIN 272
+ D + +L+ GA I+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.7 bits (239), Expect = 4e-20
Identities = 77/265 (29%), Positives = 128/265 (48%), Gaps = 12/265 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L A+S G+ IV++LL AD N+ + T L A G +D++++LL GAN+ H
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE-DH 334
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A+ + E+ ++LL GA ++F + L +A G L+ + L+ +
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 394
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 452
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA--CLVFGFSSP 246
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQI 271
C F + +F L+K GA I
Sbjct: 513 CCGGFSEVADF------LIKAGADI 531
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/268 (30%), Positives = 121/268 (45%), Gaps = 38/268 (14%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNA-TTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+GF L LAA+ GH +V+ILL+ G D A + + TPL LA G+ +V+ LLL GA
Sbjct: 1087 KGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKECQDDFGITPLFVAAQYGKLES 121
N ++ + L A+ IIK+LL GA N GI+PL +AA G + +
Sbjct: 1147 N-KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 122 LSILISSGANVNCQ-----------------------ALDK-----------ATPLFIAA 147
+ +L+ G+++N Q LD+ TPL AA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 148 QEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNK 207
G+ + +LL GAD + S + AA GH K +LLI
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325
Query: 208 VSPVYSAVFGGHEDCLEILLRNGYSPDA 235
+P++ A GGH D +++L++ G DA
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 85.1 bits (209), Expect = 1e-16
Identities = 69/225 (30%), Positives = 111/225 (49%), Gaps = 8/225 (3%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 530 DIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAAA 182
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D + + A
Sbjct: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
Query: 183 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
GH +++LL+ + + + A GGH + + LL
Sbjct: 646 --GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 387
Query: 193 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 388 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 443
Query: 249 MAFQKDC-EFFGIVNILLKYGAQINELH 275
+A C + +L++ GA + E++
Sbjct: 444 LA---ACGGHVELAALLIERGANLEEVN 468
Score = 59.7 bits (143), Expect = 5e-09
Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 4/165 (2%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T L +A G E +S+LI+ A + + TPL +AA GH VE+LL G D +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+E + P+ A G +++DLL+ ++ +P+ A GG+ + ++ILL
Sbjct: 1117 Q-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
G +++ G SP+ +A V +LL G+ IN
Sbjct: 1176 NAGAEINSRTGSKLGI-SPLMLAAMNG--HVPAVKLLLDMGSDIN 1217
Score = 54.7 bits (130), Expect = 2e-07
Identities = 40/130 (30%), Positives = 60/130 (46%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G AL A GH + +LL+AGAD + TPL A G + ++ L+ G
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
ANVN + + + A + +++LLL GA+ + G T L AA+ G +
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 684
Query: 123 SILISSGANV 132
S L+ NV
Sbjct: 685 SYLLDYPNNV 694
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/56 (37%), Positives = 36/56 (64%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+G L LA++ GH+ +VQ+L++AGAD +A + TPL A G + V++ L++
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 102 bits (254), Expect = 7e-22
Identities = 85/266 (31%), Positives = 125/266 (46%), Gaps = 39/266 (14%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT E AL A GH ++ ++LL++GA N +PL LA G +++ LL++
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD------------------ 103
GAN+ + G+ L +A+ + + E++ LLL +GAN Q
Sbjct: 461 GANLEEVNDE-GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
Query: 104 --DFGI-----------TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 150
DF I TPL A+Q G LE + L++SGANV+ T L A + G
Sbjct: 520 VADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Query: 151 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL---TNRACDTGLNK 207
HT ++LL +GA DL + + P+ AA+ GH + LI NRA T N
Sbjct: 580 HTDVADVLLQAGA--DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA--TANND 635
Query: 208 VSPVYSAVFGGHEDCLEILLRNGYSP 233
+ V A GGH +E+LL +G P
Sbjct: 636 HTVVSLACAGGHLAVVELLLAHGADP 661
Score = 100 bits (250), Expect = 2e-21
Identities = 75/230 (32%), Positives = 111/230 (48%), Gaps = 39/230 (16%)
Query: 7 FCALHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLLLQHGAN 64
+ L LAAS G+ I++ILL AGA+ N+ T + +PL LA NG + ++LLL G++
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
Query: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
+N +L A FQ AE++ LLL + AN E + G+TPL AA G E +
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 125 LISSGANVNCQ------------ALDKA-----------------------TPLFIAAQE 149
L+ GA+VN A DK TPL++A+
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 150 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR 199
GH V+LL+ +GAD D N P+ +A + GH K++ L+ N+
Sbjct: 1336 GHFDVVQLLVQAGADVDAADNRKI--TPLMSAFRKGHVKVVQYLVKEVNQ 1383
Score = 100 bits (248), Expect = 3e-21
Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G IV++LL GA+ TPL A G ++V R+LL HGA +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + ++++ LL GA++E + D T L A G +E +L
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA +L D P+ AA+ G
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREG 482
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 483 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ADIELGCS 536
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 537 TPLMEASQEG--HLELVKYLLASGANVH 562
Score = 97.8 bits (242), Expect = 2e-20
Identities = 73/266 (27%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
AL LA + GH ++V +L+ A + TPL LA G + V+ +LL G ++
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 128
L A E++ LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 129 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
GA +N + K +PL +AA GH V+LLL G+D + E + + A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1236
Query: 187 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSP 246
+++ LL+ ++P+ A GG+ + +LL G +A S
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP---VPSSRD 1293
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQIN 272
+ D + +L+ GA I+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.7 bits (239), Expect = 4e-20
Identities = 77/265 (29%), Positives = 128/265 (48%), Gaps = 12/265 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L A+S G+ IV++LL AD N+ + T L A G +D++++LL GAN+ H
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE-DH 334
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A+ + E+ ++LL GA ++F + L +A G L+ + L+ +
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 394
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 452
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA--CLVFGFSSP 246
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQI 271
C F + +F L+K GA I
Sbjct: 513 CCGGFSEVADF------LIKAGADI 531
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/268 (30%), Positives = 121/268 (45%), Gaps = 38/268 (14%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNA-TTLEETTPLFLAVENGQIDVLRLLLQHGA 63
+GF L LAA+ GH +V+ILL+ G D A + + TPL LA G+ +V+ LLL GA
Sbjct: 1087 KGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA 1146
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKECQDDFGITPLFVAAQYGKLES 121
N ++ + L A+ IIK+LL GA N GI+PL +AA G + +
Sbjct: 1147 N-KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 122 LSILISSGANVNCQ-----------------------ALDK-----------ATPLFIAA 147
+ +L+ G+++N Q LD+ TPL AA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
Query: 148 QEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNK 207
G+ + +LL GAD + S + AA GH K +LLI
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325
Query: 208 VSPVYSAVFGGHEDCLEILLRNGYSPDA 235
+P++ A GGH D +++L++ G DA
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 85.1 bits (209), Expect = 1e-16
Identities = 69/225 (30%), Positives = 111/225 (49%), Gaps = 8/225 (3%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 530 DIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
Query: 124 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAAA 182
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D + + A
Sbjct: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
Query: 183 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
GH +++LL+ + + + A GGH + + LL
Sbjct: 646 --GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 387
Query: 193 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 388 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 443
Query: 249 MAFQKDC-EFFGIVNILLKYGAQINELH 275
+A C + +L++ GA + E++
Sbjct: 444 LA---ACGGHVELAALLIERGANLEEVN 468
Score = 59.7 bits (143), Expect = 5e-09
Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 4/165 (2%)
Query: 108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
T L +A G E +S+LI+ A + + TPL +AA GH VE+LL G D +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 168 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
+E + P+ A G +++DLL+ ++ +P+ A GG+ + ++ILL
Sbjct: 1117 Q-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 228 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 272
G +++ G SP+ +A V +LL G+ IN
Sbjct: 1176 NAGAEINSRTGSKLGI-SPLMLAAMNG--HVPAVKLLLDMGSDIN 1217
Score = 54.7 bits (130), Expect = 2e-07
Identities = 40/130 (30%), Positives = 60/130 (46%)
Query: 3 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 62
T G AL A GH + +LL+AGAD + TPL A G + ++ L+ G
Sbjct: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
Query: 63 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 122
ANVN + + + A + +++LLL GA+ + G T L AA+ G +
Sbjct: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVV 684
Query: 123 SILISSGANV 132
S L+ NV
Sbjct: 685 SYLLDYPNNV 694
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/56 (37%), Positives = 36/56 (64%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
+G L LA++ GH+ +VQ+L++AGAD +A + TPL A G + V++ L++
Sbjct: 1324 KGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 100 bits (248), Expect = 3e-21
Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G IV++LL GA+ TPL A G ++V R+LL HGA +
Sbjct: 305 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 364
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + ++++ LL GA++E + D T L A G +E +L
Sbjct: 365 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 424
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA +L D P+ AA+ G
Sbjct: 425 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREG 482
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 483 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ADIELGCS 536
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 537 TPLMEASQEG--HLELVKYLLASGANVH 562
Score = 96.7 bits (239), Expect = 4e-20
Identities = 77/265 (29%), Positives = 128/265 (48%), Gaps = 12/265 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L A+S G+ IV++LL AD N+ + T L A G +D++++LL GAN+ H
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE-DH 334
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A+ + E+ ++LL GA ++F + L +A G L+ + L+ +
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 394
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 452
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA--CLVFGFSSP 246
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQI 271
C F + +F L+K GA I
Sbjct: 513 CCGGFSEVADF------LIKAGADI 531
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 7/194 (3%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT E AL A GH ++ ++LL++GA N +PL LA G +++ LL++
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ-DDFGITPLFVAAQYGKLE 120
GAN+ + G+ L +A+ + + E++ LLL +GAN Q ++ T L +A G E
Sbjct: 461 GANLEEVNDE-GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
LI +GA++ L +TPL A+QEGH + V+ LL+SGA +++ + +
Sbjct: 520 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGA--NVHATTATGDTALTY 574
Query: 181 AAQMGHTKILDLLI 194
A + GHT + D+L+
Sbjct: 575 ACENGHTDVADVLL 588
Score = 85.1 bits (209), Expect = 1e-16
Identities = 56/157 (35%), Positives = 80/157 (50%), Gaps = 3/157 (1%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L LAA GH ++ +L+E GA+ E TPL A G +++ LLL GAN+N
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
+L A +E+ L++ GA+ E TPL A+Q G LE + L++SG
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 166
ANV+ T L A + GHT ++LL +GAD D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 387
Query: 193 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 388 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 443
Query: 249 MAFQKDC-EFFGIVNILLKYGAQINELH 275
+A C + +L++ GA + E++
Sbjct: 444 LA---ACGGHVELAALLIERGANLEEVN 468
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 5/132 (3%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ GA
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 530 DIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
Query: 124 ILISSGANVNCQ 135
+L+ +GA+++ Q
Sbjct: 586 VLLQAGADLDKQ 597
Score = 47.8 bits (112), Expect = 2e-05
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 71
A+ +GH ++V+ LL +GA+ +ATT T L A ENG DV +LLQ GA+++ M
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 100 bits (248), Expect = 3e-21
Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 11/268 (4%)
Query: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 65
G AL A + G IV++LL GA+ TPL A G ++V R+LL HGA +
Sbjct: 294 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI 353
Query: 66 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 125
N + ++L A ++ + ++++ LL GA++E + D T L A G +E +L
Sbjct: 354 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 413
Query: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 185
+ SGA VN A +PL +AA GH + LL+ GA +L D P+ AA+ G
Sbjct: 414 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTPLMEAAREG 471
Query: 186 HTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFS 244
H +++ LL+ N T + + + A GG + + L++ G A + G S
Sbjct: 472 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ADIELGCS 525
Query: 245 SPVCMAFQKDCEFFGIVNILLKYGAQIN 272
+P+ A Q+ +V LL GA ++
Sbjct: 526 TPLMEASQEG--HLELVKYLLASGANVH 551
Score = 96.7 bits (239), Expect = 4e-20
Identities = 77/265 (29%), Positives = 128/265 (48%), Gaps = 12/265 (4%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L A+S G+ IV++LL AD N+ + T L A G +D++++LL GAN+ H
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE-DH 323
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLESLSILISS 128
+ G L +A+ + E+ ++LL GA ++F + L +A G L+ + L+ +
Sbjct: 324 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA 383
Query: 129 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 188
GA+ + + T L A +GH + LLL SGA ++ DS++ P+ AA GH +
Sbjct: 384 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTLAACGGHVE 441
Query: 189 ILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA--CLVFGFSSP 246
+ LLI + +P+ A GHE+ + +LL G + +AQ +
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
Query: 247 VCMAFQKDCEFFGIVNILLKYGAQI 271
C F + +F L+K GA I
Sbjct: 502 CCGGFSEVADF------LIKAGADI 520
Score = 90.9 bits (224), Expect = 2e-18
Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 7/194 (3%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
KT E AL A GH ++ ++LL++GA N +PL LA G +++ LL++
Sbjct: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
Query: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQ-DDFGITPLFVAAQYGKLE 120
GAN+ + G+ L +A+ + + E++ LLL +GAN Q ++ T L +A G E
Sbjct: 450 GANLEEVNDE-GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 508
Query: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
LI +GA++ L +TPL A+QEGH + V+ LL+SGA +++ + +
Sbjct: 509 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGA--NVHATTATGDTALTY 563
Query: 181 AAQMGHTKILDLLI 194
A + GHT + D+L+
Sbjct: 564 ACENGHTDVADVLL 577
Score = 85.1 bits (209), Expect = 1e-16
Identities = 56/157 (35%), Positives = 80/157 (50%), Gaps = 3/157 (1%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
L LAA GH ++ +L+E GA+ E TPL A G +++ LLL GAN+N
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
Query: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
+L A +E+ L++ GA+ E TPL A+Q G LE + L++SG
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
Query: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 166
ANV+ T L A + GHT ++LL +GAD D
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 73.6 bits (179), Expect = 3e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 72
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
Query: 133 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 192
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 376
Query: 193 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 248
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 377 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 432
Query: 249 MAFQKDC-EFFGIVNILLKYGAQINELH 275
+A C + +L++ GA + E++
Sbjct: 433 LA---ACGGHVELAALLIERGANLEEVN 457
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 5/132 (3%)
Query: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHGA 63
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ GA
Sbjct: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
Query: 64 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 123
++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 519 DIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
Query: 124 ILISSGANVNCQ 135
+L+ +GA+++ Q
Sbjct: 575 VLLQAGADLDKQ 586
Score = 47.8 bits (112), Expect = 2e-05
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 71
A+ +GH ++V+ LL +GA+ +ATT T L A ENG DV +LLQ GA+++ M
Sbjct: 531 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 589
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 98.2 bits (243), Expect = 1e-20
Identities = 68/231 (29%), Positives = 123/231 (53%), Gaps = 12/231 (5%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLLLQHGANVNG 67
L+L+ QG + V ++L DPN + +++ TPL A + G +++ +LLQ GAN+N
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 68 SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 127
L +A + E+ + ++++G +++ G T L AA+ G LE +S+L+S
Sbjct: 680 VDKQ-QRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 128 SG-ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
+G +VN Q TP+ AA+ H + + +LL+ GAD L NE++ + +H A+ G
Sbjct: 739 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEEN--ICLHWASFTGS 796
Query: 187 TKILDLLIPLTNRACD---TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
I ++L+ N CD + +P++ A + DC+ + L G +P+
Sbjct: 797 AAIAEVLL---NARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 844
Score = 78.2 bits (191), Expect = 1e-14
Identities = 59/202 (29%), Positives = 93/202 (46%), Gaps = 35/202 (17%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LH AA +G +I +LL+AGA+ NA ++ TPL AV N ++V R ++Q G V
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 70 ---SMC------------------------------GWNSLHQASFQENAEIIKLLLRKG 96
S C GW + A+ ++ E+I++LL +G
Sbjct: 715 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 774
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ D+ L A+ G +L+++ +++ TPL IAA+E + CV
Sbjct: 775 ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL 834
Query: 157 LLLSSGADPDLYCNE--DSWQL 176
L LS GA+P+L E +W L
Sbjct: 835 LFLSRGANPELRNKEGDTAWDL 856
Score = 65.5 bits (158), Expect = 9e-11
Identities = 46/134 (34%), Positives = 71/134 (52%), Gaps = 8/134 (5%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAG-ADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
K +G LH AA G+ ++V +LL G D NA TP+ A E+ I+V+R+LL
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
Query: 61 HGANV---NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 117
GA+V + ++C LH ASF +A I ++LL + + G TPL +AA+
Sbjct: 773 RGADVTLTDNEENIC----LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 828
Query: 118 KLESLSILISSGAN 131
+ + + +S GAN
Sbjct: 829 YHDCVLLFLSRGAN 842
Score = 43.9 bits (102), Expect = 3e-04
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 5/102 (4%)
Query: 143 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 202
L+++ ++G + V L+L DP+ ++ S + P+HAAAQ G +I +L+
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 203 TGLNKVSPVYSAVFGGHEDCLEILLRNG---YS--PDAQACL 239
+ +P+ AV H + +++ G YS D CL
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCL 721
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 98.2 bits (243), Expect = 1e-20
Identities = 68/231 (29%), Positives = 123/231 (53%), Gaps = 12/231 (5%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLLLQHGANVNG 67
L+L+ QG + V ++L DPN + +++ TPL A + G +++ +LLQ GAN+N
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 68 SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 127
L +A + E+ + ++++G +++ G T L AA+ G LE +S+L+S
Sbjct: 714 VDKQ-QRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 128 SG-ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 186
+G +VN Q TP+ AA+ H + + +LL+ GAD L NE++ + +H A+ G
Sbjct: 773 TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEEN--ICLHWASFTGS 830
Query: 187 TKILDLLIPLTNRACD---TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 234
I ++L+ N CD + +P++ A + DC+ + L G +P+
Sbjct: 831 AAIAEVLL---NARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPE 878
Score = 78.2 bits (191), Expect = 1e-14
Identities = 59/202 (29%), Positives = 93/202 (46%), Gaps = 35/202 (17%)
Query: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
LH AA +G +I +LL+AGA+ NA ++ TPL AV N ++V R ++Q G V
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 70 ---SMC------------------------------GWNSLHQASFQENAEIIKLLLRKG 96
S C GW + A+ ++ E+I++LL +G
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG 808
Query: 97 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 156
A+ D+ L A+ G +L+++ +++ TPL IAA+E + CV
Sbjct: 809 ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL 868
Query: 157 LLLSSGADPDLYCNE--DSWQL 176
L LS GA+P+L E +W L
Sbjct: 869 LFLSRGANPELRNKEGDTAWDL 890
Score = 65.5 bits (158), Expect = 9e-11
Identities = 46/134 (34%), Positives = 71/134 (52%), Gaps = 8/134 (5%)
Query: 2 KTFEGFCALHLAASQGHWKIVQILLEAG-ADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
K +G LH AA G+ ++V +LL G D NA TP+ A E+ I+V+R+LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
Query: 61 HGANV---NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 117
GA+V + ++C LH ASF +A I ++LL + + G TPL +AA+
Sbjct: 807 RGADVTLTDNEENIC----LHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARES 862
Query: 118 KLESLSILISSGAN 131
+ + + +S GAN
Sbjct: 863 YHDCVLLFLSRGAN 876
Score = 43.9 bits (102), Expect = 3e-04
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 5/102 (4%)
Query: 143 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 202
L+++ ++G + V L+L DP+ ++ S + P+HAAAQ G +I +L+
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 203 TGLNKVSPVYSAVFGGHEDCLEILLRNG---YS--PDAQACL 239
+ +P+ AV H + +++ G YS D CL
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCL 755
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,868,682
Number of Sequences: 37866
Number of extensions: 737592
Number of successful extensions: 6017
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 344
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 1309
Number of HSP's gapped (non-prelim): 1946
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.