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Search of human proteins with 114155144
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens]
(248 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens] 468 e-132
gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens] 442 e-124
gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens] 420 e-118
gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens] 394 e-110
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens] 386 e-107
gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens] 365 e-101
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 352 1e-97
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 344 4e-95
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens] 343 6e-95
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 334 5e-92
gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens] 328 2e-90
gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens] 327 6e-90
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 319 1e-87
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 316 1e-86
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 315 2e-86
gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens] 300 6e-82
gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens] 271 4e-73
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 76 2e-14
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 76 3e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 74 9e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 74 9e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 1e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 1e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 1e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 1e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 1e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 1e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 1e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 74 1e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 73 2e-13
>gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens]
Length = 248
Score = 468 bits (1204), Expect = e-132
Identities = 248/248 (100%), Positives = 248/248 (100%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLLDLNEM 248
TLLDLNEM
Sbjct: 241 TLLDLNEM 248
>gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens]
Length = 248
Score = 442 bits (1138), Expect = e-124
Identities = 233/248 (93%), Positives = 240/248 (96%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLLDLNEM 248
TLLDLNEM
Sbjct: 241 TLLDLNEM 248
>gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
Length = 247
Score = 420 bits (1079), Expect = e-118
Identities = 228/245 (93%), Positives = 231/245 (94%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLLDL 245
TL DL
Sbjct: 241 TLHDL 245
>gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens]
Length = 247
Score = 394 bits (1013), Expect = e-110
Identities = 213/245 (86%), Positives = 223/245 (91%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLLDL 245
TL DL
Sbjct: 241 TLHDL 245
>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
Length = 248
Score = 386 bits (991), Expect = e-107
Identities = 199/246 (80%), Positives = 228/246 (92%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG+ ++EAVKRKIQ LQQQAD+AE+RA+ LQRE++GER RE+AE +VA+LNRRIQLVE
Sbjct: 1 MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
EADRKYEEVARKLVI+EG+LER EERAE++E KC +LEEELKNVTNNLKSLEA +EKYS+
Sbjct: 121 EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIK+L+DKLKEAETRAEFAER+VAKLEKTIDDLE+KL KEE++ + LDQ
Sbjct: 181 KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ 240
Query: 241 TLLDLN 246
TL +LN
Sbjct: 241 TLNELN 246
Score = 58.5 bits (140), Expect = 5e-09
Identities = 37/161 (22%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 88 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 147
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 148 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 207
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + L + L N L +
Sbjct: 208 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 248
>gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens]
Length = 245
Score = 365 bits (938), Expect = e-101
Identities = 196/247 (79%), Positives = 222/247 (89%), Gaps = 3/247 (1%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG +++EAV+RKI+ LQ+QAD AEERA LQRE++ ER+ RE AEA+VASLNRRIQLVE
Sbjct: 1 MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
+ADRKYEEVARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQ
Sbjct: 121 DADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KED+YEEEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L E++ +R+ ++
Sbjct: 181 KEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQN---RRLTNE 237
Query: 241 TLLDLNE 247
L LNE
Sbjct: 238 LKLALNE 244
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 352 bits (904), Expect = 1e-97
Identities = 190/242 (78%), Positives = 207/242 (85%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ A+++K++ + + D E + Q ++E + AEAEVASLNRRIQLVEEELDRA
Sbjct: 44 LAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRA 103
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY
Sbjct: 104 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 163
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE
Sbjct: 164 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 223
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED+L K ++ LD L D+
Sbjct: 224 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMT 283
Query: 247 EM 248
+
Sbjct: 284 SI 285
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 344 bits (883), Expect = 4e-95
Identities = 181/240 (75%), Positives = 208/240 (86%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
Length = 284
Score = 343 bits (881), Expect = 6e-95
Identities = 182/242 (75%), Positives = 207/242 (85%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELN 282
Query: 247 EM 248
M
Sbjct: 283 NM 284
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 334 bits (856), Expect = 5e-92
Identities = 174/237 (73%), Positives = 205/237 (86%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
+++K++ + + D E + Q ++E + AE +VA+LNRRIQLVEEELDRAQER
Sbjct: 46 LQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQER 105
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
LATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAEEADRKYEEV
Sbjct: 106 LATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEV 165
Query: 130 ARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
ARKLVI+EG+LER EERAE++E KC +LEEELKNVTNNLKSLEA +EKYS+KEDKYEEEI
Sbjct: 166 ARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEI 225
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
K+L+DKLKEAETRAEFAER+VAKLEKTIDDLE+KL KEE++ + LDQTL +LN
Sbjct: 226 KLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELN 282
Score = 58.5 bits (140), Expect = 5e-09
Identities = 37/161 (22%), Positives = 80/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 124 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 184 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSL 171
R + +E ++ EE+ A+ + L + L N L +
Sbjct: 244 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 284
>gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]
Length = 284
Score = 328 bits (842), Expect = 2e-90
Identities = 171/241 (70%), Positives = 203/241 (84%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AESKC +LEEELK VTNNLKSLEAQA+KYS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLED++ K ++ LD L D+
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITS 283
Query: 248 M 248
+
Sbjct: 284 L 284
Score = 34.3 bits (77), Expect = 0.10
Identities = 18/62 (29%), Positives = 34/62 (54%)
Query: 5 TTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
T + + +I++L+++ +AE RAE +R V + + E EV + + + + EELD
Sbjct: 216 TKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELD 275
Query: 65 RA 66
A
Sbjct: 276 NA 277
>gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]
Length = 284
Score = 327 bits (838), Expect = 6e-90
Identities = 173/240 (72%), Positives = 200/240 (83%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E KC+ELEEELK VTNNLKSLEAQAEKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L K ++ LD L D+ +
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI 284
Score = 55.1 bits (131), Expect = 6e-08
Identities = 33/114 (28%), Positives = 61/114 (53%)
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
+ + +K+ +++ D E +RAE AE+ E+ K + + L SL+ + + + DKY
Sbjct: 2 DAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYS 61
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
E +K +KL+ AE +A AE VA L + I +E++L +E + L++
Sbjct: 62 EALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEE 115
Score = 39.7 bits (91), Expect = 0.002
Identities = 34/138 (24%), Positives = 64/138 (46%), Gaps = 14/138 (10%)
Query: 102 EEKMELQEIQLKEAKHIAE--EADRKYEEVARK-----LVIIEGDLERTEERAELAESKC 154
++KM++ ++ + A AE EAD+K E K LV ++ L+ TE+ +
Sbjct: 5 KKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEAL 64
Query: 155 SELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTD-------KLKEAETRAEFAE 207
+ +E+L+ EA +++ EEE+ + KL+EAE A+ +E
Sbjct: 65 KDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE 124
Query: 208 RSVAKLEKTIDDLEDKLK 225
R + +E E+K++
Sbjct: 125 RGMKVIESRAQKDEEKME 142
>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
Length = 284
Score = 319 bits (818), Expect = 1e-87
Identities = 167/241 (69%), Positives = 202/241 (83%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AES+ +LEEEL+ + LKSL A E+YS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLE+ L KEE++ + LDQTLL+LN
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNN 283
Query: 248 M 248
+
Sbjct: 284 L 284
>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
Length = 284
Score = 316 bits (810), Expect = 1e-86
Identities = 167/240 (69%), Positives = 200/240 (83%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 315 bits (808), Expect = 2e-86
Identities = 168/242 (69%), Positives = 199/242 (82%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELN 282
Query: 247 EM 248
M
Sbjct: 283 NM 284
>gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]
Length = 284
Score = 300 bits (769), Expect = 6e-82
Identities = 160/240 (66%), Positives = 192/240 (80%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + +LEE+L+ + LK+L A +KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L K ++ LD L D+ M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM 284
>gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens]
Length = 231
Score = 271 bits (693), Expect = 4e-73
Identities = 144/242 (59%), Positives = 189/242 (78%), Gaps = 11/242 (4%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A+K+K+Q+L+ ++A +RAE+ + + + +Q E E +L ++++ E+E++
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVE-- 58
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
K E+EKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKY
Sbjct: 59 ---------KYSESEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKY 109
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
EEVARKLVI+EG+LER+EERAE+AES+ +LEEEL+ + LKSL A E+YS KEDKYE
Sbjct: 110 EEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYE 169
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L +KLKEAETRAEFAERSVAKLEKTIDDLE+ L KEE++ + LDQTLL+LN
Sbjct: 170 EEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELN 229
Query: 247 EM 248
+
Sbjct: 230 NL 231
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 76.3 bits (186), Expect = 2e-14
Identities = 71/252 (28%), Positives = 115/252 (45%), Gaps = 42/252 (16%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL---QREVEGERRAREQAEAEVASLNRRIQLVEE-- 61
++ +R+ + +++AD+A++R E L Q E+ + + E+A+ E A L ++
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 62 ------------ELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE 109
E +R +E LA A+Q+L++A++AA G++ A +EK LQE
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLE--RQVAGLQQEKESLQE 963
Query: 110 IQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLK 169
+LK AK A G L + + AE + L+E N LK
Sbjct: 964 -KLKAAKAAA------------------GSLPGLQAQLAQAEQRAQSLQEAAHQELNTLK 1004
Query: 170 -SLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTK 228
L A+ Y + EE K L +L+E + + AE +V KL+ T D+ +KL CT
Sbjct: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCT- 1063
Query: 229 EEHL--CTQRML 238
HL C ML
Sbjct: 1064 SNHLAECQAAML 1075
Score = 53.1 bits (126), Expect = 2e-07
Identities = 42/216 (19%), Positives = 96/216 (44%), Gaps = 12/216 (5%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 84
E + L +E+E R + ++ +AS + + +++ D A + +A +
Sbjct: 341 ESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEM 400
Query: 85 DESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEADRKYEEVARKLVIIEGDLE 141
E ++ +E K EE Q QL++ + E+A E + +++ ++ +L
Sbjct: 401 QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELS 460
Query: 142 RTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAET 201
+ A+ + EL + L L + ++ ++++ E+E++ LT +L
Sbjct: 461 GKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL----- 515
Query: 202 RAEFAERSVAKLEKTIDDLEDKLK--CTKEEHLCTQ 235
+F E +A++ + + DLE++ K ++HL Q
Sbjct: 516 --QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
Score = 46.2 bits (108), Expect = 3e-05
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERR-----AREQAEAEVASLNR-RIQLVEEE 62
A++R +LQ A + E + L ++ + A Q +A+ AS + R + + +
Sbjct: 336 ALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSD 395
Query: 63 LDRAQERLATALQKLEEAEKAADESERGM-----KVIENRALKDEEKMELQEIQLKEAKH 117
+ + L LQ LE +E R ++++ LK++ + L+ + +KE
Sbjct: 396 AAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERL-VKEMAP 454
Query: 118 IAEEADRKYEEVARKLVIIEGDLERT----EERAELAESKCSE------LEEELKNVTNN 167
+ EE K +E + ++ L T EE AEL K + LE+E++++T
Sbjct: 455 LQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQ 514
Query: 168 LKSLEAQAEKYSQKEDKYEEEIK-ILTDK 195
L+ LE Q + SQ EE+ K ++ DK
Sbjct: 515 LQFLETQLAQVSQHVSDLEEQKKQLIQDK 543
Score = 44.3 bits (103), Expect = 1e-04
Identities = 62/250 (24%), Positives = 111/250 (44%), Gaps = 37/250 (14%)
Query: 8 EAVKRKIQVLQQQADDAEERAER----------LQREV-EGERRAREQAEAEVASLNR-R 55
E ++R++ LQQ+ + +E+ + LQ ++ + E+RA+ EA LN +
Sbjct: 945 EGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLK 1004
Query: 56 IQLVEEELD------RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE 109
QL E +D A E + +LEE + +E ++ ++ EK+
Sbjct: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064
Query: 110 IQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSE----LEEELKNVT 165
L E + D++ + DLERT++ E A +K E L +E+ N
Sbjct: 1065 NHLAECQAAMLRKDKEG-------AALREDLERTQKELEKATTKIQEYYNKLCQEVTNRE 1117
Query: 166 NNLKSLEAQAEKYSQKEDKYEEE--IKILTDK--LKEAETRAEFAERSVAKLEKTIDDLE 221
N + + A + ++ + KY EE I++L DK L + EF ++ A+ E+ + D E
Sbjct: 1118 RNDQKMLADLDDLNRTK-KYLEERLIELLRDKDALWQKSDALEFQQKLSAE-ERWLGDTE 1175
Query: 222 DK--LKCTKE 229
L C +E
Sbjct: 1176 ANHCLDCKRE 1185
Score = 43.9 bits (102), Expect = 1e-04
Identities = 45/230 (19%), Positives = 100/230 (43%), Gaps = 8/230 (3%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEE---ELDRAQERLATALQ 75
Q+ + E+ + L+RE Q A++ L + +QL E+ L+R + +A +
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
Query: 76 KLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVI 135
+L + AD+ R ++ + EE++ + K+ + E +++ + R+L
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF 517
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQK---EDKYEEEIKIL 192
+E L + + E + +L ++ +++ + LE A + + E + +
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
Query: 193 TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTL 242
L+EA + E +R + E +DD + + +EE R L++ L
Sbjct: 578 NSSLQEAWGKPEEEQRGLQ--EAQLDDTKVQEGSQEEELRQANRELEKEL 625
Score = 41.2 bits (95), Expect = 8e-04
Identities = 44/237 (18%), Positives = 100/237 (42%), Gaps = 28/237 (11%)
Query: 36 EGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 95
E E+R ++A+ + + Q EEEL +A L LQ + + + + ++ +
Sbjct: 589 EEEQRGLQEAQLDDTKVQEGSQ--EEELRQANRELEKELQNVVGRNQLLEGKLQALQA-D 645
Query: 96 NRALKDEEKM---ELQEIQLKEA--KHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
+AL+ E L ++ ++A +H+ ++ + V + ++ + E +
Sbjct: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSK 705
Query: 151 ESKCSELEEELKNVT-------NNLKSLEAQAEKYSQKED-------------KYEEEIK 190
E +C +L EE++ L++LE+Q ++ +Q + + E +
Sbjct: 706 EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEAR 765
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
L +L ++ + E + V +L+ + DL+ K++ ++ Q L L E
Sbjct: 766 ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLRE 822
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 75.9 bits (185), Expect = 3e-14
Identities = 46/213 (21%), Positives = 105/213 (49%), Gaps = 5/213 (2%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQA-----EAEVASLNRRIQLVEEELDRAQERLAT 72
Q++ + EE+ + ++ E E+R ++A E ++ +I+ EE + +E++
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M+ E + + E+K+ QE +++E + + +E + K E K
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Query: 133 LVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKIL 192
+ E ++ EE+ E K E E++++ ++ E ++ +K + EE++
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 535
Query: 193 TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
+K++E E + E + + E + E+K++
Sbjct: 536 EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 73.2 bits (178), Expect = 2e-13
Identities = 48/224 (21%), Positives = 113/224 (50%), Gaps = 2/224 (0%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL-QREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E ++R+ +++ ++ + E E++ ++E E+ + Q E ++ +R Q E ++ R
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQ 388
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ E E+ E E M E + + EE+M+ QE +++ + E ++K
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 186
E K+ E ++ EE+ E K E E +++ ++ E + + +K + E
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
E+I+ + ++E E + E + + E+ + + E+K++ +E+
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Score = 71.6 bits (174), Expect = 6e-13
Identities = 59/248 (23%), Positives = 120/248 (48%), Gaps = 35/248 (14%)
Query: 19 QQADDAEERAERLQ------REVEGERRAREQAEAEVASLNRR-----------IQLVEE 61
+Q + +ER E++Q RE E + R +E+ E RR I+ +EE
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 62 ELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEE 121
++ QE++ +K +E EK ++ +R + E + + EEK+ QE +++E + + +E
Sbjct: 352 KM-HEQEKIREQEEKRQEEEKIREQEKRQEQ--EAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 122 ADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEK 177
+ K E K+ E +++ EE+ E K E E++++ ++ ++ Q EK
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 178 YSQKEDK----------YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCT 227
++E K EE+++ +K++E E + E + + E+ + + E+K+
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM-WE 527
Query: 228 KEEHLCTQ 235
+EE +C Q
Sbjct: 528 QEEKMCEQ 535
Score = 65.9 bits (159), Expect = 3e-11
Identities = 63/256 (24%), Positives = 117/256 (45%), Gaps = 28/256 (10%)
Query: 7 IEAVKRKI---------QVLQQQAD----DAEERAERLQREVEGER---RAREQAEAEVA 50
++ +KRK+ Q LQ +AD + + + +LQ +VE R +Q E ++
Sbjct: 232 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 291
Query: 51 SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI 110
+IQ EE++ +E++ +K+ E+ E E M+ E + EEK+ E
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 111 QLKEAKHIAEEADRKYEEVA----RKLVIIEGDLERTEERAELAESKCSELEEELKNVTN 166
++ E + I E+ +++ EE K E + R EE+ E K E EE ++
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411
Query: 167 NLKSLEA----QAEKYSQKEDKY---EEEIKILTDKLKEAETRAEFAERSVAKLEKTIDD 219
+ E Q E+ ++E+K EE+I+ K++E E + E + + E+ + +
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGE 471
Query: 220 LEDKLKCTKEEHLCTQ 235
E K+ C +E + Q
Sbjct: 472 QEGKM-CEQEAKMQEQ 486
Score = 60.1 bits (144), Expect = 2e-09
Identities = 48/190 (25%), Positives = 93/190 (48%), Gaps = 8/190 (4%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E +Q E E + EQ E ++ +Q EE++ R +E++
Sbjct: 387 RQEEKIREQEEKIREQEEMMQ---EQEEKMGEQEE-KMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E E+ E E M+ E + + E KM QE +++E + + K E +
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY-EEEIK 190
K+ E + EE + E K E EE++ + ++ Q EK ++E+K E+E++
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKM---CEQEEKMQEQEEKMRRQEEKMREQEVR 559
Query: 191 ILTDKLKEAE 200
+ + K E
Sbjct: 560 LRQQEEKMQE 569
Score = 58.9 bits (141), Expect = 4e-09
Identities = 36/174 (20%), Positives = 85/174 (48%), Gaps = 3/174 (1%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL---QREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
E ++ + +++Q+Q + E+ E++ + E++ + + E ++ ++I+ EE++
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
+E + +K+ E E E E M+ E + + EEK+ QE +++E + E +
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+E K+ E + EE+ + E K EE+++ L+ E + +++
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 54.7 bits (130), Expect = 7e-08
Identities = 56/246 (22%), Positives = 108/246 (43%), Gaps = 33/246 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 67 QERLATALQKLEEA-------EKAADESERGMKV----------IENRAL------KDEE 103
Q + +KLE A + A+ G ++ +E L + EE
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 104 KMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
KM QE +++E + +E + K E K+ E + EE+ E E EE+++
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+ + + EK ++E+K +EE +K++E E R E E + + E+ I + E+K
Sbjct: 349 LEEKMH----EQEKIREQEEKRQEE-----EKIREQEKRQE-QEAKMWRQEEKIREQEEK 398
Query: 224 LKCTKE 229
++ +E
Sbjct: 399 IREQEE 404
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 74.3 bits (181), Expect = 9e-14
Identities = 60/233 (25%), Positives = 113/233 (48%), Gaps = 15/233 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRAREQAEAEVASLNRRIQLVEEE 62
+E+ K +IQ+ + ERA+ L Q +VE +R +E + S + Q+ E E
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE---LQSVSAKLQAQVEENE 286
Query: 63 L-----DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 117
L + +E++ +K++E E+ E E ++ E + + EEKM QE +++E +
Sbjct: 287 LWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQED 346
Query: 118 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEK 177
+ K E K+ E + R EE+ + K E EEE+ ++ Q EK
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE---QEEK 403
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
+K + E++++ +K++E E E + +LE+ + D E+KL+ +E+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Score = 72.8 bits (177), Expect = 3e-13
Identities = 48/213 (22%), Positives = 108/213 (50%), Gaps = 1/213 (0%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
K+ E ++ EE+ + K + EE++ + E + + +K + EE+++
Sbjct: 470 KIQRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+K++E E R E + + E + +LE++L
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 67.0 bits (162), Expect = 1e-11
Identities = 51/215 (23%), Positives = 113/215 (52%), Gaps = 10/215 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
+ E+ E+ E E K ELEE +++ L+ +E + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +K++E E + + + + K E+ I + E+K+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKM 505
Score = 65.9 bits (159), Expect = 3e-11
Identities = 47/199 (23%), Positives = 101/199 (50%), Gaps = 5/199 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E ++ + + +Q+Q ++ + E+++ + E + + E ++ + +I+ EEE+ R +
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE--IQLKEAKHIAEEADRK 125
E++ + +++ E+ E E M+ E + + EEK++ QE IQ +E K +E K
Sbjct: 434 EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Query: 126 YEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
EE K+ E + R EE+ E K E EE+++ ++ E + + +K +
Sbjct: 494 QEE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQ 550
Query: 186 EEEIKILTDKLKEAETRAE 204
E ++ L ++L + +AE
Sbjct: 551 EVRLQELEERLGKLGQKAE 569
Score = 61.2 bits (147), Expect = 8e-10
Identities = 54/233 (23%), Positives = 114/233 (48%), Gaps = 14/233 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----KSLEAQAEKYS 179
K E ++ E + EE + E K E+EE+++ + + ++ Q EK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
++E+K + K+L +K+ E E + E + + E+ + + E+K++ +E+
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
Score = 61.2 bits (147), Expect = 8e-10
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 8/185 (4%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ KI+ L++ D EE+ ++ +++ E ++ E ++ +IQ EE+ R QE+L
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR-QEKL 491
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+K+ E E+ E M E + + EEKM+ QE +++E + + + K +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551
Query: 131 RKLVIIEGDLERTEERAEL-----AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
+L +E L + ++AEL ES L + LKS EAQ+ Q++D Y
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQS--LQQQQDHY 609
Query: 186 EEEIK 190
++
Sbjct: 610 RGHLQ 614
Score = 51.6 bits (122), Expect = 6e-07
Identities = 39/179 (21%), Positives = 89/179 (49%), Gaps = 12/179 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ V+ K+Q +++ + EE+ +R + +++ E+ + + ++ +I EE++ R
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K++E E+ E M+ E R + EEKM+ QE++L +E + +
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRL-------QELEERL 561
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
++ +K ++ G E ++ + L+ ELK + +SL+ Q + Y +Y
Sbjct: 562 GKLGQKAELLGG--AGRESGSQRLPTLTPILQVELK--SQEAQSLQQQQDHYRGHLQQY 616
Score = 43.5 bits (101), Expect = 2e-04
Identities = 53/229 (23%), Positives = 98/229 (42%), Gaps = 35/229 (15%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
E +L ++ EE+ E K E EE K LK E + + + Q+E +E+E K
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQEEK 340
Query: 191 I---------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
I +K++E E + E + + E+ I + ++K++ +EE
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 74.3 bits (181), Expect = 9e-14
Identities = 60/233 (25%), Positives = 113/233 (48%), Gaps = 15/233 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRAREQAEAEVASLNRRIQLVEEE 62
+E+ K +IQ+ + ERA+ L Q +VE +R +E + S + Q+ E E
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKE---LQSVSAKLQAQVEENE 286
Query: 63 L-----DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 117
L + +E++ +K++E E+ E E ++ E + + EEKM QE +++E +
Sbjct: 287 LWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQED 346
Query: 118 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEK 177
+ K E K+ E + R EE+ + K E EEE+ ++ Q EK
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE---QEEK 403
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
+K + E++++ +K++E E E + +LE+ + D E+KL+ +E+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Score = 72.8 bits (177), Expect = 3e-13
Identities = 48/213 (22%), Positives = 108/213 (50%), Gaps = 1/213 (0%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKI 191
K+ E ++ EE+ + K + EE++ + E + + +K + EE+++
Sbjct: 470 KIQRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 192 LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+K++E E R E + + E + +LE++L
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 67.0 bits (162), Expect = 1e-11
Identities = 51/215 (23%), Positives = 113/215 (52%), Gaps = 10/215 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
+ E+ E+ E E K ELEE +++ L+ +E + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +K++E E + + + + K E+ I + E+K+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKM 505
Score = 65.9 bits (159), Expect = 3e-11
Identities = 47/199 (23%), Positives = 101/199 (50%), Gaps = 5/199 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E ++ + + +Q+Q ++ + E+++ + E + + E ++ + +I+ EEE+ R +
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQE 433
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE--IQLKEAKHIAEEADRK 125
E++ + +++ E+ E E M+ E + + EEK++ QE IQ +E K +E K
Sbjct: 434 EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Query: 126 YEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
EE K+ E + R EE+ E K E EE+++ ++ E + + +K +
Sbjct: 494 QEE---KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQ 550
Query: 186 EEEIKILTDKLKEAETRAE 204
E ++ L ++L + +AE
Sbjct: 551 EVRLQELEERLGKLGQKAE 569
Score = 61.2 bits (147), Expect = 8e-10
Identities = 54/233 (23%), Positives = 114/233 (48%), Gaps = 14/233 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----KSLEAQAEKYS 179
K E ++ E + EE + E K E+EE+++ + + ++ Q EK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
++E+K + K+L +K+ E E + E + + E+ + + E+K++ +E+
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
Score = 61.2 bits (147), Expect = 8e-10
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 8/185 (4%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ KI+ L++ D EE+ ++ +++ E ++ E ++ +IQ EE+ R QE+L
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR-QEKL 491
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+K+ E E+ E M E + + EEKM+ QE +++E + + + K +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551
Query: 131 RKLVIIEGDLERTEERAEL-----AESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
+L +E L + ++AEL ES L + LKS EAQ+ Q++D Y
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQS--LQQQQDHY 609
Query: 186 EEEIK 190
++
Sbjct: 610 RGHLQ 614
Score = 51.6 bits (122), Expect = 6e-07
Identities = 39/179 (21%), Positives = 89/179 (49%), Gaps = 12/179 (6%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ V+ K+Q +++ + EE+ +R + +++ E+ + + ++ +I EE++ R
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K++E E+ E M+ E R + EEKM+ QE++L +E + +
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRL-------QELEERL 561
Query: 127 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKY 185
++ +K ++ G E ++ + L+ ELK + +SL+ Q + Y +Y
Sbjct: 562 GKLGQKAELLGG--AGRESGSQRLPTLTPILQVELK--SQEAQSLQQQQDHYRGHLQQY 616
Score = 43.5 bits (101), Expect = 2e-04
Identities = 53/229 (23%), Positives = 98/229 (42%), Gaps = 35/229 (15%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
E +L ++ EE+ E K E EE K LK E + + + Q+E +E+E K
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQEEK 340
Query: 191 I---------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
I +K++E E + E + + E+ I + ++K++ +EE
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1708 RLAAEQEL 1715
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2291
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2292 RLRQLAEEDLAQQRALAEKML 2312
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2478
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2479 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2526
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2527 AQQLREEQQRQQQQMEQ 2543
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1719
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1780 STSEKSKQRL 1789
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2605
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1839
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1840 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1883
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1884 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1930
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2363 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2418
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2419 RTE---LATQEKVTLVQTL 2434
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2098
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2099 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2144
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2145 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1556
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2537
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2591
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2592 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1337 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1393 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2050
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2111 VEEAE-RLKQSAEE 2123
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1419 QEELQQLRQSSEAEI 1433
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1986 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2042 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1532
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1533 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1712 RLAAEQEL 1719
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2177
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2295
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2296 RLRQLAEEDLAQQRALAEKML 2316
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2433
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2434 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2482
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2483 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2530
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2531 AQQLREEQQRQQQQMEQ 2547
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1723
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1784 STSEKSKQRL 1793
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2609
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1790 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1843
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1844 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1887
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1888 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1934
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2247
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2306
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2367 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2422
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2423 RTE---LATQEKVTLVQTL 2438
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1987
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2144
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2102
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2103 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2148
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2149 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1403 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1560
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2541
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2542 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2595
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2596 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2646
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2647 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1341 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1396
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1397 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1453
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1499
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1895 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1952 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2001
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 2002 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2054
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2115 VEEAE-RLKQSAEE 2127
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1182
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1242
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1243 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1423 QEELQQLRQSSEAEI 1437
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1990 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2046 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1708 RLAAEQEL 1715
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2291
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2292 RLRQLAEEDLAQQRALAEKML 2312
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2478
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2479 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2526
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2527 AQQLREEQQRQQQQMEQ 2543
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1719
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1780 STSEKSKQRL 1789
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2605
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1839
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1840 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1883
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1884 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1930
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2363 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2418
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2419 RTE---LATQEKVTLVQTL 2434
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2098
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2099 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2144
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2145 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1556
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2537
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2538 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2591
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2592 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1337 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1393 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2050
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2111 VEEAE-RLKQSAEE 2123
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1419 QEELQQLRQSSEAEI 1433
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1986 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2042 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1496
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1497 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1676 RLAAEQEL 1683
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2141
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2259
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2260 RLRQLAEEDLAQQRALAEKML 2280
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2397
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2398 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2446
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2447 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2494
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2495 AQQLREEQQRQQQQMEQ 2511
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1687
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1748 STSEKSKQRL 1757
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2573
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1754 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1807
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1808 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1851
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1852 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1898
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2211
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2270
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2331 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2386
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2387 RTE---LATQEKVTLVQTL 2402
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1951
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2108
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2066
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2067 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2112
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2113 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1367 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1524
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2505
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2506 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2559
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2560 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2610
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2611 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1305 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1360
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1361 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1417
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1463
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1859 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1916 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1965
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 1966 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2018
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2079 VEEAE-RLKQSAEE 2091
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1146
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1206
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1207 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1266
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1267 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1326
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1387 QEELQQLRQSSEAEI 1401
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1954 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2010 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1665
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1666 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1845 RLAAEQEL 1852
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2310
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2428
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2429 RLRQLAEEDLAQQRALAEKML 2449
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2566
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2567 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2615
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2616 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2663
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2664 AQQLREEQQRQQQQMEQ 2680
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1856
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1917 STSEKSKQRL 1926
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2742
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1923 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1976
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1977 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 2020
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 2021 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 2067
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2380
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2439
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2500 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2555
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2556 RTE---LATQEKVTLVQTL 2571
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 2120
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2277
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2235
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2236 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2281
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2282 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1536 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1693
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2674
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2675 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2728
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2729 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2779
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2780 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1474 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1529
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1530 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1586
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 2028 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 2085 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2134
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 2135 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2187
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2248 VEEAE-RLKQSAEE 2260
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1315
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1375
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1376 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1435
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1556 QEELQQLRQSSEAEI 1570
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 2123 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2179 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1506
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1507 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1686 RLAAEQEL 1693
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2094
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2151
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2269
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2270 RLRQLAEEDLAQQRALAEKML 2290
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2407
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2408 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2456
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2457 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2504
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2505 AQQLREEQQRQQQQMEQ 2521
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1697
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1758 STSEKSKQRL 1767
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2583
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1764 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1817
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1818 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1861
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1862 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1908
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2221
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2280
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2341 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2396
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2397 RTE---LATQEKVTLVQTL 2412
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1961
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2118
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2076
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2077 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2122
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2123 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2169
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1377 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1534
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2515
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2516 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2569
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2570 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2620
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2621 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1315 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1370
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1371 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1427
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1869 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1925
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1926 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1975
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 1976 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2028
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2089 VEEAE-RLKQSAEE 2101
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1156
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1216
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1217 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1276
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1277 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1336
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1397 QEELQQLRQSSEAEI 1411
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1964 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2019
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2020 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1514
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1515 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1694 RLAAEQEL 1701
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2102
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2159
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2277
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2278 RLRQLAEEDLAQQRALAEKML 2298
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2415
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2416 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2464
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2465 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2512
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2513 AQQLREEQQRQQQQMEQ 2529
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1705
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1766 STSEKSKQRL 1775
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2591
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1772 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1825
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1826 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1869
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1870 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1916
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2229
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2288
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2349 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2404
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2405 RTE---LATQEKVTLVQTL 2420
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1969
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2089
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2126
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2084
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2085 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2130
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2131 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2177
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1384
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1385 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1542
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2523
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2524 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2577
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2578 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2628
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2629 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1323 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1378
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1379 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1435
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1481
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1877 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1933
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1934 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1983
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 1984 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2036
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2097 VEEAE-RLKQSAEE 2109
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1106 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1164
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1224
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1225 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1284
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1285 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1344
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1405 QEELQQLRQSSEAEI 1419
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 1972 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2027
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2028 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.9 bits (180), Expect = 1e-13
Identities = 68/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1555
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1556 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 120 EEA--DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN---VTNNLKSLEAQ 174
+ A +R +E + + + ER ++ AE E E EL+ N L Q
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 175 AEKYSQKEDKYEEEI-KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AE+ +Q++ + E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1735 RLAAEQEL 1742
Score = 69.3 bits (168), Expect = 3e-12
Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 31/261 (11%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2143
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2200
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEEL-------KNVTNNLKSL 171
AE+ R+ +V ++L + LE T+ + L + + L+ E V L S+
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 172 EAQAEKYSQKEDKYEEEIK--ILTDK-------LKEAETRAEFAERSVAKLEKTIDDLED 222
Q E+ S+ + + E E + IL DK +EAE + AE + A+L +
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA-ARLSVAAQEAA- 2318
Query: 223 KLKCTKEEHLCTQRMLDQTLL 243
+L+ EE L QR L + +L
Sbjct: 2319 RLRQLAEEDLAQQRALAEKML 2339
Score = 63.5 bits (153), Expect = 2e-10
Identities = 68/257 (26%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2456
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKN 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + K EE++
Sbjct: 2457 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLK----SEEMQT 2505
Query: 164 VTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
V E QA + S +K D L + R F E+ AKLE+ D K
Sbjct: 2506 VQQEQLLQETQALQQSFLSEK---------DSLLQ---RERFIEQEKAKLEQLFQDEVAK 2553
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2554 AQQLREEQQRQQQQMEQ 2570
Score = 62.0 bits (149), Expect = 5e-10
Identities = 63/250 (25%), Positives = 110/250 (44%), Gaps = 22/250 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDRA 66
EA +R Q ++A + E QR E E +++ + AE A L R +Q + +
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRA-------LKDEEKMELQEIQLKEAKHIA 119
+E Q+ EAE+A +E+ER ++ + +A L+ EE + + + EA+
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 120 EEADRKY-------EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLE 172
EEA+R+ E+ R+ + E +LE+ + AE + E+EL L
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-------LR 1746
Query: 173 AQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
A+ E+ Q+ EEE+ L + A + + E +AK+ ++ L +EE
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 233 CTQRMLDQTL 242
T Q L
Sbjct: 1807 STSEKSKQRL 1816
Score = 58.9 bits (141), Expect = 4e-09
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561
Query: 130 ARKLVIIEGDLERTEERAELAESKCSE-----LEEELKNVTNNLKSLEAQ-AEKYSQKED 183
+ L + E E R AE + + LE ++ L+S A AEK +Q E
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659
Score = 57.0 bits (136), Expect = 1e-08
Identities = 55/233 (23%), Positives = 118/233 (50%), Gaps = 19/233 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 65 RAQERLATALQKLE-EAEKAADESERGMKVIENRALKDEEKMELQEIQ-LKEAKHIAEEA 122
ERL A+ +LE E EK E+ K+++ LK EE +Q+ Q L+E + + +
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEA----KLLQ---LKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS----LEAQAEKY 178
+ + + ++ IE + + E+ + +K +L EE + ++ L A E+
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 179 SQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
+++ + EE ++ ++L++ E + E +A+ + L ++L+ +E+H
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR---LREQLQLLEEQH 2632
Score = 55.5 bits (132), Expect = 4e-08
Identities = 64/232 (27%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1813 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1866
Query: 134 VIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A E+E +N + L AE + + + EE+
Sbjct: 1867 AAI-GEATRLKTEAEIALK-----EKEAEN-----ERLRRLAEDEAFQRRRLEEQ----- 1910
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1911 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1957
Score = 54.7 bits (130), Expect = 7e-08
Identities = 57/259 (22%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2270
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2329
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNL----- 168
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + L+E+ + + L
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 169 ---KSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++LEA+ ++ + + E +K+ ++ A+ R AE + K +++ +KL
Sbjct: 2390 GFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQAR---AEEDAQRFRKQAEEIGEKLH 2445
Query: 226 CTKEEHLCTQR--MLDQTL 242
T+ L TQ L QTL
Sbjct: 2446 RTE---LATQEKVTLVQTL 2461
Score = 53.1 bits (126), Expect = 2e-07
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 2010
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKY 178
+K EE A + E +L++T ++ + + E + + QAE+
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
Query: 179 SQKEDKYEEEIKILTDKLKE-AETRAEFAERSVAKLEK 215
+ + + EE + L +E A+ RA+ A+ + KL K
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2167
Score = 53.1 bits (126), Expect = 2e-07
Identities = 57/230 (24%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R EE V
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV- 2125
Query: 136 IEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDK 195
+ + E + R ++ E+ E LK AQA+ ++K K E+
Sbjct: 2126 -QAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLRKEAEQ------- 2171
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2172 --EAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2218
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/223 (22%), Positives = 103/223 (46%), Gaps = 27/223 (12%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1426 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN 167
+QL+ + A+ + + + + E + +E AE + + + +
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 168 LKS---LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L S EA+A + Q+ + EE+++ + +EAE R AE
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRL---QAEEAERRLRQAE 1583
Score = 47.4 bits (111), Expect = 1e-05
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 26/220 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQA-EAEVASLNRRIQLVEEELDRA 66
E + ++ Q LQQ ++ + +R +E E+ EQ + EVA + Q + EE R
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQQLREEQQRQ 2564
Query: 67 QERLATALQKL----EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
Q+++ Q+L EEA + E+E G++ K EE +L++ + ++ + +AEE
Sbjct: 2565 QQQMEQERQRLVASMEEARRRQHEAEEGVR------RKQEELQQLEQQRRQQEELLAEEN 2618
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESK--CSELEEELKNVTNNLKSLEAQAEKYSQ 180
R E++ L + RA LA S+ + K + N +L+ A +
Sbjct: 2619 QRLREQL---------QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2669
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 220
+ K+ +L+EA + + +A+ T+D+L
Sbjct: 2670 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709
Score = 47.0 bits (110), Expect = 2e-05
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 12/166 (7%)
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE-EADRKYEE 128
++ L+++EE E+ A++ + E L + E ++ QL EA A+ +A+R+ +E
Sbjct: 1364 ISETLRRMEEEERLAEQQ----RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1419
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNN----LKSLEAQAEKYSQKEDK 184
+ +++ + ++ R EE A A+ + ++EEL+ + + +++ QAE + +
Sbjct: 1420 LQQRM---QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1476
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEEI+++ +L+ E + AE + L ++ E + + +EE
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 54/254 (21%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1918 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1974
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1975 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2024
Query: 123 DRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKE 182
EE AR+ ++ER + + E A E+E L+ + A+K Q E
Sbjct: 2025 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQE---SARQLQLAQEAAQKRLQAE 2077
Query: 183 DK--------YEEEI-------KILTDKLK-----------EAETRAEFAERSVAKLEKT 216
+K E+E+ + + D+L+ EAE AER A+ +
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 217 IDDLEDKLKCTKEE 230
+++ E +LK + EE
Sbjct: 2138 VEEAE-RLKQSAEE 2150
Score = 43.9 bits (102), Expect = 1e-04
Identities = 67/315 (21%), Positives = 121/315 (38%), Gaps = 85/315 (26%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1205
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1265
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLE---- 141
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1266 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1325
Query: 142 --------------------------------------------RTEERAELAESKCSEL 157
R EE LAE + +E
Sbjct: 1326 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1385
Query: 158 EEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E L V L+ AE ++Q + + E E K L +++E R E A + +++I
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
Query: 218 DDLEDKLKCTKEEHL 232
+ +L+ + E +
Sbjct: 1446 QEELQQLRQSSEAEI 1460
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 17/234 (7%)
Query: 17 LQQQADDAEERAERL-----QREVEGERRAREQAEAEVASLNRRIQLVEEEL---DRAQE 68
L++ A+D + RL Q + + E R + +A + L R+ LVE+ L + +E
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ E+A E E + I + A E E++ + +A E +R+ E
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
+ ++ L EE A ++ E+ E LK + L +AE+ S ++ + +E
Sbjct: 2013 AEER---VQKSLAAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE 2068
Query: 189 IKILTDKLKEAETRAE-FA-ERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
K +AE +A FA ++ +L++T+ + L + E +R ++
Sbjct: 2069 ---AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 73.2 bits (178), Expect = 2e-13
Identities = 62/258 (24%), Positives = 135/258 (52%), Gaps = 28/258 (10%)
Query: 6 TIEAVKRKIQVLQQQADDAEER-AERLQREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
TI+ +++ L+QQA + + + A+ LQ++ + + R Q E +SL ++ Q ++E +
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 65 RAQ-------ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLK---E 114
+ + ++LATA EE E + E + +K +E + K+E+ + QL+ E
Sbjct: 573 KQEATRQDHAQQLATAA---EEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 115 AKHIAE----EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKS 170
A+ A+ +A R+ E++RK+ ++ +E + A+++ +ELE +L++ +
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE----QQ 685
Query: 171 LEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
+ E+ +Q++D+ +E+++ L + LK + E +R A D LE++ +C E
Sbjct: 686 KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAA------DALEEQQRCISEL 739
Query: 231 HLCTQRMLDQTLLDLNEM 248
T+ +++Q + E+
Sbjct: 740 KAETRSLVEQHKRERKEL 757
Score = 66.6 bits (161), Expect = 2e-11
Identities = 60/257 (23%), Positives = 121/257 (47%), Gaps = 38/257 (14%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+EA++ ++ L+QQ +E+A+ L+R +E ER +R + ++ + +L +++ +EL +
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 67 QERLATALQ-------KLEEAEKAADESE----RGMKVIENR-----ALKDEEKMELQEI 110
Q LA+A + K+++ KA DE + RG + E + +L++E + +++
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Query: 111 -----QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVT 165
+ KE K + K +++ +L +++ + T + A + S L EE
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAE---TASNSARAAERSSALREE----- 1293
Query: 166 NNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
++SL +AEK + +E+ +AE E + A EK E L
Sbjct: 1294 --VQSLREEAEKQRVASENLRQEL------TSQAERAEELGQELKAWQEKFFQK-EQALS 1344
Query: 226 CTKEEHLCTQRMLDQTL 242
+ EH TQ ++ + L
Sbjct: 1345 TLQLEHTSTQALVSELL 1361
Score = 53.5 bits (127), Expect = 2e-07
Identities = 54/244 (22%), Positives = 111/244 (45%), Gaps = 34/244 (13%)
Query: 8 EAVKRKIQVLQQQADDAEERAER--------LQREVEGERRAREQAEAEVASLNRRIQLV 59
E + + +V +Q+ + RAE+ + ++ G + E A+L R Q +
Sbjct: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGR--QFL 1465
Query: 60 EEELDRAQERL--------ATALQKLEEAEKAADESERGM------------KVIENRAL 99
E ELD+A+E+ A A +L E ++ A + R + KV+E R
Sbjct: 1466 EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR 1525
Query: 100 KDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEE 159
EE+ +L Q+++ + E ++ EE+++KL + + +++ + +++ E ++
Sbjct: 1526 FQEERQKLTA-QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
Query: 160 ELKNVTNNLKSLEAQAEKYSQKEDKYE---EEIKILTDKLKEAETRAEFAERSVAKLEKT 216
E + + L L+AQ + Q + Y+ E+ K D K+ + RS+ +L+K
Sbjct: 1585 EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 217 IDDL 220
+L
Sbjct: 1645 NKEL 1648
Score = 51.2 bits (121), Expect = 8e-07
Identities = 52/237 (21%), Positives = 111/237 (46%), Gaps = 35/237 (14%)
Query: 17 LQQQADDAEERAERLQR--EVEGERRAREQAE--AEVASLNRRIQLVEEEL----DRAQE 68
LQ + + E L++ + G R + A +E+ +LN IQ ++EL +A+E
Sbjct: 471 LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
+ A Q L++ E+A+ ++ + + +LK +E+ QLKE +AE+ + ++
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSS-SLKQKEQ------QLKE---VAEKQEATRQD 580
Query: 129 VARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEE 188
A++L + E E L+ LK LEA ++ + K + +++
Sbjct: 581 HAQQLA-----------------TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+++ + A+T A+R A+L + +++L+ ++ ++E Q + + L L
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
Score = 47.4 bits (111), Expect = 1e-05
Identities = 57/245 (23%), Positives = 116/245 (47%), Gaps = 31/245 (12%)
Query: 11 KRKIQVLQQQADDAEERAERLQREV--EGERRAREQAEAEVASLNRR-----IQLVEEEL 63
+++ Q +Q+ E+ E QRE + E +++ A+++ AS ++ +Q E
Sbjct: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGES 1582
Query: 64 DRAQERLATALQKLE----EAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
+ +RL L +L+ + E+AA+ + M+ + + D +K + QE+Q
Sbjct: 1583 QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQME--KAKTHYDAKKQQNQELQ-------- 1632
Query: 120 EEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYS 179
E R E++ ++ + + ER + A K E E+ +++T ++SLEAQ ++
Sbjct: 1633 -EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQV-AHA 1690
Query: 180 QKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLD 239
++ + + ++ TD LK E +A+ +L+ +ID L+ L C + L L
Sbjct: 1691 DQQLRDLGKFQVATDALKSREPQAK------PQLDLSIDSLD--LSCEEGTPLSITSKLP 1742
Query: 240 QTLLD 244
+T D
Sbjct: 1743 RTQPD 1747
Score = 45.1 bits (105), Expect = 6e-05
Identities = 43/222 (19%), Positives = 97/222 (43%), Gaps = 5/222 (2%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + + +++ Q EER ++ +REV + R +A+A++A +E L A
Sbjct: 980 ELERLRAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 68 ERLATALQKLEEAEKAADESERG--MKVIENRALKDEEKMELQEIQ--LKEAKHIAEEAD 123
L+EA A + G ++ + R L+ + EL+E++ +K+ K + +
Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKED 183
+++ + G E T + E ++ S+LE++ + SLE E
Sbjct: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRA 1158
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
+ + ++ L +L+E ++ ++A ++ + K++
Sbjct: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
Score = 44.7 bits (104), Expect = 8e-05
Identities = 48/224 (21%), Positives = 98/224 (43%), Gaps = 19/224 (8%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLE 78
QQ + E RA++L ++ + EVA L ++ E+ + A L +
Sbjct: 886 QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG 945
Query: 79 EAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLV 134
+ + E ++G + +A++ E + E++ A + + ++ E ++
Sbjct: 946 DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
Query: 135 IIEGDLERTEERAELAESKC--SELEEELKNVTNNLK-----SLEAQAEKYSQKEDKYEE 187
+ ER +A+LA K +ELE L+N N + EA A ++KE K +E
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
K+ L+ A+ + + +L +T+ L+++L ++EH
Sbjct: 1066 LAKL--RGLEAAQI------KELEELRQTVKQLKEQLAKKEKEH 1101
Score = 43.9 bits (102), Expect = 1e-04
Identities = 41/205 (20%), Positives = 91/205 (44%), Gaps = 15/205 (7%)
Query: 30 RLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESER 89
RL++++ ER R++ E E+A + + + ++ Q+R+ L L E + A+ +
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI-DRLALLNEKQAASPLEPK 276
Query: 90 GMKVIENRALKDEEKMELQEI--QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERA 147
++ + ++ + M L E Q ++ K + DRK +++ + + L
Sbjct: 277 ELEELRDK--NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 148 ELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
+ + +EL EE T +++ +K+ + E+E+ K E + E +
Sbjct: 335 QQLQDALNELTEEHSKAT----------QEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384
Query: 208 RSVAKLEKTIDDLEDKLKCTKEEHL 232
+++LE+ + L+D K E L
Sbjct: 385 GKLSQLEEHLSQLQDNPPQEKGEVL 409
Score = 43.9 bits (102), Expect = 1e-04
Identities = 50/235 (21%), Positives = 99/235 (42%), Gaps = 23/235 (9%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLV----EEELDRAQERLATALQKLEEA 80
+E+ L+ E E R+ ++A+ +VA + +L + EL LA ALQ+++E
Sbjct: 832 QEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK 891
Query: 81 EKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLV---IIE 137
E A + + + +EKM ++ + + +A + E +R+LV
Sbjct: 892 EVRAQKLADDLSTL-------QEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA 944
Query: 138 GDLERTEERAELAESKCS------ELEEELKNVTNNLKSLEA--QAEKYSQKEDKYEEEI 189
GD + + CS +E E + + N L+ L A + Q+E++ ++E
Sbjct: 945 GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER 1004
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLD 244
++ + +A+ A A+ E + L++ L + E Q L L +
Sbjct: 1005 EVARLTQERGRAQADLALEKAARAELEM-RLQNALNEQRVEFATLQEALAHALTE 1058
Score = 43.1 bits (100), Expect = 2e-04
Identities = 52/213 (24%), Positives = 89/213 (41%), Gaps = 11/213 (5%)
Query: 17 LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQK 76
LQ +AE+ L+R ++ Q + E R + + +E RAQ L AL+K
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL--ALEK 1024
Query: 77 LEEAE------KAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
AE A +E ++ + E ++ +L + + + ++ EE+
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 131 RKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIK 190
+ + ++ L + E+ SE + L++L A+ K Q+ K +E+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
L L EAE RA AER A LE LE+K
Sbjct: 1145 SLERSL-EAE-RASRAERDSA-LETLQGQLEEK 1174
Score = 42.7 bits (99), Expect = 3e-04
Identities = 52/257 (20%), Positives = 108/257 (42%), Gaps = 49/257 (19%)
Query: 17 LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQ-------------LVEEEL 63
L++Q D + L+ E+ R+ + +A++A + +RI L +EL
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278
Query: 64 DRAQERLATALQKLEEAEKAA-----DESERGMKVIENRALKDEEKMELQEI-----QLK 113
+ +++ + +L E K ++S+ K+ + + +L+E QL+
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338
Query: 114 EA-KHIAEEADRKYEEVARKLVIIEGDLERT-------EERAELAESKCSELEEELKNVT 165
+A + EE + +E K +E +L EE+ E+ + K S+LEE L +
Sbjct: 339 DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
Query: 166 NN--------------LKSLEAQAEKYSQKEDKYEEEIKILTDK--LKEAETRAE--FAE 207
+N L++L+ +A + + + +++L + +EA+ AE E
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 208 RSVAKLEKTIDDLEDKL 224
+L I DL+ +
Sbjct: 459 EEKQQLSSLITDLQSSI 475
Score = 42.0 bits (97), Expect = 5e-04
Identities = 42/179 (23%), Positives = 78/179 (43%), Gaps = 18/179 (10%)
Query: 17 LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQK 76
LQQ + + E L+RE+ A+ AE+E L + + E + +Q+
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ-------- 822
Query: 77 LEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEA---KHIAEEADRKYEEVARKL 133
EEA+ A E+ M + E ++ + ELQE + K A H + R+ E+A
Sbjct: 823 -EEAQYGAMFQEQLMTLKEE---CEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
Query: 134 VIIEGDLERTEE---RAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEI 189
+ L++ +E RA+ S L+E++ + + LE K ++++ E+
Sbjct: 879 ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937
Score = 34.7 bits (78), Expect = 0.079
Identities = 44/227 (19%), Positives = 96/227 (42%), Gaps = 15/227 (6%)
Query: 11 KRKIQVLQQQADDAEERAERLQ---REVEGERRAREQA----EAEVASLNRRIQLVEEEL 63
++K++ +Q Q ++++ A+RLQ E++ + +EQA + ++ +++
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN 1628
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMEL---QEIQLKEAKHIAE 120
QE+L + Q +E ++ E+ER ++ LK +E + Q++ +
Sbjct: 1629 QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELE---EELKNVTNNLKSLEAQAEK 177
AD++ ++ + V + R + + L+ EE ++ K Q +
Sbjct: 1689 HADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDG 1748
Query: 178 YSQKEDKYEEEIKILTDKLKEAETR--AEFAERSVAKLEKTIDDLED 222
S + + L K++ E+ RS A LE ++D L D
Sbjct: 1749 TSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGD 1795
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.304
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,525,877
Number of Sequences: 37866
Number of extensions: 339831
Number of successful extensions: 14069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 843
Number of HSP's successfully gapped in prelim test: 922
Number of HSP's that attempted gapping in prelim test: 2924
Number of HSP's gapped (non-prelim): 6362
length of query: 248
length of database: 18,247,518
effective HSP length: 100
effective length of query: 148
effective length of database: 14,460,918
effective search space: 2140215864
effective search space used: 2140215864
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.