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Search of human proteins with 219521876
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
(526 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 1092 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 833 0.0
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 833 0.0
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 833 0.0
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 579 e-165
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 579 e-165
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 546 e-155
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 545 e-155
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 497 e-141
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 350 2e-96
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 348 7e-96
gi|4502023 AKT2 kinase [Homo sapiens] 329 3e-90
gi|62241015 AKT1 kinase [Homo sapiens] 326 4e-89
gi|62241013 AKT1 kinase [Homo sapiens] 326 4e-89
gi|62241011 AKT1 kinase [Homo sapiens] 326 4e-89
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 308 8e-84
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 306 2e-83
gi|4506067 protein kinase C, alpha [Homo sapiens] 299 4e-81
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 299 5e-81
gi|4885563 protein kinase C, epsilon [Homo sapiens] 296 3e-80
gi|133908623 protein kinase C, iota [Homo sapiens] 294 2e-79
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 289 5e-78
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 289 5e-78
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 289 5e-78
gi|13384594 protein kinase C, gamma [Homo sapiens] 288 6e-78
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 287 1e-77
gi|28557781 protein kinase C, eta [Homo sapiens] 286 4e-77
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 284 1e-76
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 283 2e-76
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 1092 bits (2824), Expect = 0.0
Identities = 526/526 (100%), Positives = 526/526 (100%)
Query: 1 MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPSLKYTGSSMVHIPPGEPDF 60
MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPSLKYTGSSMVHIPPGEPDF
Sbjct: 1 MVNKDMNGFPVKKCSAFQFFKKRVRRWIKSPMVSVDKHQSPSLKYTGSSMVHIPPGEPDF 60
Query: 61 ESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNHANILTKPDPRTFWTNDDP 120
ESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNHANILTKPDPRTFWTNDDP
Sbjct: 61 ESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNHANILTKPDPRTFWTNDDP 120
Query: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
Query: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
Query: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
Query: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
Query: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
Query: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 26 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 85
Query: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 86 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 145
Query: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 146 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 205
Query: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 206 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 265
Query: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 266 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 325
Query: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 326 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
Query: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 386 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 431
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 40 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 99
Query: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 100 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 159
Query: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 160 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 219
Query: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 220 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 279
Query: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 280 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 339
Query: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 340 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 400 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 445
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 833 bits (2152), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 121 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 180
AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL
Sbjct: 54 AFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINL 113
Query: 181 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 240
GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS
Sbjct: 114 GPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMS 173
Query: 241 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 300
ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE
Sbjct: 174 ERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 233
Query: 301 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 360
IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA
Sbjct: 234 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 293
Query: 361 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 420
PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR
Sbjct: 294 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSAR 353
Query: 421 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF
Sbjct: 354 HLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
Query: 481 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
Sbjct: 414 DPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 459
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 579 bits (1492), Expect = e-165
Identities = 285/430 (66%), Positives = 338/430 (78%), Gaps = 13/430 (3%)
Query: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162
A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+
Sbjct: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
Query: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213
++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
Query: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273
+ FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
Query: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333
+NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
Query: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393
TDFGLCKE I + TT+TFCGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
Query: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453
R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF +
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 422
Query: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513
+W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF
Sbjct: 423 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 482
Query: 514 LGFSYAPPTD 523
+GFSYAPP++
Sbjct: 483 VGFSYAPPSE 492
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 579 bits (1492), Expect = e-165
Identities = 285/430 (66%), Positives = 338/430 (78%), Gaps = 13/430 (3%)
Query: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162
A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+
Sbjct: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
Query: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213
++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
Query: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273
+ FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
Query: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333
+NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
Query: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393
TDFGLCKE I + TT+TFCGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
Query: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453
R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF +
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 422
Query: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513
+W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF
Sbjct: 423 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 482
Query: 514 LGFSYAPPTD 523
+GFSYAPP++
Sbjct: 483 VGFSYAPPSE 492
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 546 bits (1408), Expect = e-155
Identities = 266/391 (68%), Positives = 321/391 (82%), Gaps = 14/391 (3%)
Query: 147 PEVQSILKISQPQEPEL------MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHF 195
P ++ + P PEL MN++P+ PSP INLGPS+NP+A+P+DF F
Sbjct: 38 PPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDF 97
Query: 196 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 255
LKVIGKG++GKVLLA+ K++ FYAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLV
Sbjct: 98 LKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLV 157
Query: 256 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 315
GL +SFQT +KLYFVLDY+NGGELF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+Y
Sbjct: 158 GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIY 217
Query: 316 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 375
RDLKPENILLD QGH+VLTDFGLCKE +E TTSTFCGTPEYLAPEVL K+PYDR VDW
Sbjct: 218 RDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDW 277
Query: 376 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 435
WCLGAVLYEML+GLPPFYS++ ++MY+NIL++PLQ+ T +A LL+ LL KD+ +RL
Sbjct: 278 WCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 337
Query: 436 GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGK 495
G+K DF+EIK+HVFFS INWDDL +K++TPPFNPNV+GP DL+HFDPEFT+E V SIG
Sbjct: 338 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGC 397
Query: 496 SPDSVLVTASVKEAAEAFLGFSYAPPTDSFL 526
+PD+V AS A+ AFLGFSYAP D L
Sbjct: 398 TPDTV---ASSSGASSAFLGFSYAPEDDDIL 425
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 545 bits (1404), Expect = e-155
Identities = 261/368 (70%), Positives = 313/368 (85%), Gaps = 8/368 (2%)
Query: 164 MNANPSPPPSPSQQ-----INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 218
MN++P+ PSP INLGPS+NP+A+P+DF FLKVIGKG++GKVLLA+ K++ F
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 219 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 278
YAVKVLQKK+ILKKKE+ HIM+ER+VLLKNV+HPFLVGL +SFQT +KLYFVLDY+NGGE
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGE 120
Query: 279 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 338
LF+HLQRER FLEPRARFYAAE+ASA+GYLHSLNI+YRDLKPENILLD QGH+VLTDFGL
Sbjct: 121 LFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGL 180
Query: 339 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA 398
CKE +E TTSTFCGTPEYLAPEVL K+PYDR VDWWCLGAVLYEML+GLPPFYS++ +
Sbjct: 181 CKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVS 240
Query: 399 EMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDL 458
+MY+NIL++PLQ+ T +A LL+ LL KD+ +RLG+K DF+EIK+HVFFS INWDDL
Sbjct: 241 QMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDL 300
Query: 459 INKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
+K++TPPFNPNV+GP DL+HFDPEFT+E V SIG +PD+V AS A+ AFLGFSY
Sbjct: 301 YHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSY 357
Query: 519 APPTDSFL 526
AP D L
Sbjct: 358 APEDDDIL 365
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 497 bits (1280), Expect = e-141
Identities = 256/430 (59%), Positives = 308/430 (71%), Gaps = 45/430 (10%)
Query: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162
A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+
Sbjct: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
Query: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213
++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
Query: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273
+ FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
Query: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333
+NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
Query: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393
TDFGLCKE I + TT+TFCGTPE PPFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPE--------------------------------PPFY 330
Query: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453
R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF +
Sbjct: 331 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 390
Query: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513
+W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF
Sbjct: 391 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 450
Query: 514 LGFSYAPPTD 523
+GFSYAPP++
Sbjct: 451 VGFSYAPPSE 460
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 350 bits (897), Expect = 2e-96
Identities = 179/374 (47%), Positives = 241/374 (64%), Gaps = 4/374 (1%)
Query: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTAS 505
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + + + + D +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCM 460
Query: 506 VKEAAEAFLGFSYA 519
E F FSY+
Sbjct: 461 DNERRPHFPQFSYS 474
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 348 bits (893), Expect = 7e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
Query: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
Query: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
Query: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
Query: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
Query: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 489
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
Query: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
Query: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
Query: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
Query: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
Query: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 489
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 4e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 153 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 211
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 271
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 272 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 330
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 449
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 509
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 510 AEAFLGFSYA 519
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 4e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 153 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 211
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 271
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 272 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 330
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 449
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 509
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 510 AEAFLGFSYA 519
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 326 bits (835), Expect = 4e-89
Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)
Query: 153 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 211
LK + +E + + +PS S ++++ + + H ++F +LK++GKG+FGKV+L +
Sbjct: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
Query: 212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 271
KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L +SFQT D+L FV+
Sbjct: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
Query: 272 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 330
+Y NGGELF+HL RER F E RARFY AEI SAL YLHS N+VYRDLK EN++LD GH
Sbjct: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
Query: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390
I +TDFGLCKE I+ +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+ G
Sbjct: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
Query: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 449
PFY+++ ++++ IL + ++ + A+ LL GLL+KD +RL G +D EI H F
Sbjct: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
Query: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 509
F+ I W + KK++PPF P V+ D R+FD EFT + + + DS+ S E
Sbjct: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
Query: 510 AEAFLGFSYA 519
F FSY+
Sbjct: 466 RPHFPQFSYS 475
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 308 bits (789), Expect = 8e-84
Identities = 163/351 (46%), Positives = 225/351 (64%), Gaps = 18/351 (5%)
Query: 178 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKK-K 233
+N GP +P F L+V+GKG +GKV R +A+KVL+K I++ K
Sbjct: 79 VNRGPEK---IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK 135
Query: 234 EEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR 293
+ H +ERN+L + VKHPF+V L ++FQT KLY +L+Y++GGELF L+RE F+E
Sbjct: 136 DTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDT 194
Query: 294 ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 353
A FY AEI+ ALG+LH I+YRDLKPENI+L+ QGH+ LTDFGLCKE+I + T TFC
Sbjct: 195 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 254
Query: 354 GTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP 413
GT EY+APE+L + ++R VDWW LGA++Y+ML G PPF N + D IL L L P
Sbjct: 255 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 314
Query: 414 NITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 472
+T AR LL+ LL+++ RLGA D E+++H FF INW++L+ +K+ PPF P +
Sbjct: 315 YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ 374
Query: 473 GPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
D+ FD +FT + PV SPD ++ S A + FLGF+Y P+
Sbjct: 375 SEEDVSQFDSKFTRQTPV-----DSPDDSTLSES---ANQVFLGFTYVAPS 417
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 178 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 232
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
Query: 233 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 291
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
Query: 292 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 351
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
Query: 352 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 411
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
Query: 412 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 470
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
Query: 471 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 299 bits (766), Expect = 4e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 122 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 181
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
Query: 182 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 225
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
Query: 226 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 285
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
Query: 286 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 345
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
Query: 346 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 405
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
Query: 406 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 464
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
Query: 465 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 299 bits (765), Expect = 5e-81
Identities = 150/334 (44%), Positives = 210/334 (62%), Gaps = 7/334 (2%)
Query: 189 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 248
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 249 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 308
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 309 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 368
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 369 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 428
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 429 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487
K KRLG + +IK H FF I+W+ L K+I PP+ P D +FD EFT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637
Query: 488 PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
PV +P L ++ + F GFSY P
Sbjct: 638 PVE----LTPTDKLFIMNLDQ--NEFAGFSYTNP 665
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 296 bits (758), Expect = 3e-80
Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)
Query: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
+F+F+KV+GKGSFGKV+LA K ++ YAVKVL+K IL+ + M+E+ +L KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
Query: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
P+L L+ FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
Query: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
++YRDLK +NILLD++GH L DFG+CKE I + TT+TFCGTP+Y+APE+L + Y
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
Query: 372 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 431
+VDWW LG ++YEM+ G PPF + N +++++IL+ + ++ A +L+ + K+
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
Query: 432 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 487
KRLG +++ IK H FF I+W L KKI PPF P + D+ +FD +FT EE
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
Query: 488 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 518
PV + + A VK+ E F GFSY
Sbjct: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 294 bits (752), Expect = 2e-79
Identities = 154/374 (41%), Positives = 227/374 (60%), Gaps = 29/374 (7%)
Query: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVF 218
+E E MN S S S + DF L+VIG+GS+ KVLL R K +
Sbjct: 232 EEKEAMNTRESGKASSSLGLQ------------DFDLLRVIGRGSYAKVLLVRLKKTDRI 279
Query: 219 YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGE 278
YA+KV++K+ + ++ + +E++V + HPFLVGLH FQT +L+FV++Y+NGG+
Sbjct: 280 YAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGD 339
Query: 279 LFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGL 338
L +H+QR+R E ARFY+AEI+ AL YLH I+YRDLK +N+LLDS+GHI LTD+G+
Sbjct: 340 LMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGM 399
Query: 339 CKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPF------ 392
CKE + TTSTFCGTP Y+APE+L + Y +VDWW LG +++EM+ G PF
Sbjct: 400 CKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSS 459
Query: 393 --YSRNTAE-MYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA--KDDFMEIKSH 447
+NT + ++ IL K +++ +++ A +L+ L KD +RLG + F +I+ H
Sbjct: 460 DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 519
Query: 448 VFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVK 507
FF ++WD + K++ PPF PN+SG L +FD +FT EPV +PD + +
Sbjct: 520 PFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQ----LTPDDDDIVRKID 575
Query: 508 EAAEAFLGFSYAPP 521
++ F GF Y P
Sbjct: 576 QS--EFEGFEYINP 587
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 5e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 289 bits (739), Expect = 5e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
+FT EPV +PD + ++ F GF Y P
Sbjct: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 289 bits (739), Expect = 5e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
+FT EPV +PD + ++ F GF Y P
Sbjct: 551 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 583
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 288 bits (738), Expect = 6e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 143 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 200
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
Query: 201 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 255
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
Query: 256 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 315
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
Query: 316 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 375
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
Query: 376 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 435
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
Query: 436 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 494
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
Query: 495 KSPDSVLVTASVKEAAEAFLGFSYAPP 521
+P LV AS+ +A F GF+Y P
Sbjct: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 287 bits (735), Expect = 1e-77
Identities = 141/301 (46%), Positives = 196/301 (65%), Gaps = 2/301 (0%)
Query: 189 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 248
K +DF+FL V+GKGSFGKV+L+ K + YAVK+L+K +++ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 249 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYL 308
K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+ F EP A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 309 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQP 368
S I+YRDLK +N++LDS+GHI + DFG+CKENI TT TFCGTP+Y+APE++ QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 369 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQ 428
Y ++VDWW G +LYEML G PF + E++ +I+ + +++ A + +GL+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 429 KDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487
K KRLG + +IK H FF I+W+ L K+I PP+ P G N +FD FT
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRN-AENFDRFFTRH 636
Query: 488 P 488
P
Sbjct: 637 P 637
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 286 bits (731), Expect = 4e-77
Identities = 150/345 (43%), Positives = 213/345 (61%), Gaps = 10/345 (2%)
Query: 180 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIM 239
+G +S+ +F F++V+GKGSFGKV+LAR K YAVKVL+K IL+ + + M
Sbjct: 342 IGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 401
Query: 240 SERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAA 299
+E+ +L HPFL L FQT D+L+FV++++NGG+L +H+Q+ R F E RARFYAA
Sbjct: 402 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 461
Query: 300 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 359
EI SAL +LH I+YRDLK +N+LLD +GH L DFG+CKE I + TT+TFCGTP+Y+
Sbjct: 462 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYI 521
Query: 360 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSA 419
APE+L + Y VDWW +G +LYEML G PF + N ++++ ILN + + A
Sbjct: 522 APEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDA 581
Query: 420 RHLLEGLLQKDRTKRLGAKDDFME--IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL 477
+L+ + K+ T RLG+ E I H FF I+W L +++I PPF P + D+
Sbjct: 582 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 641
Query: 478 RHFDPEF-TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
+FDP+F EEPV I + ++ + F FSY P
Sbjct: 642 SNFDPDFIKEEPVLTPIDEGHLPMI-------NQDEFRNFSYVSP 679
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 284 bits (727), Expect = 1e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 188 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 244
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
Query: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 425 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
FT + +S G P + A + F GFS+ T
Sbjct: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
Score = 118 bits (296), Expect = 1e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 199 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 258
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
Query: 259 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 318
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 319 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 374
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 375 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 427
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 428 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 486
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
Query: 487 EPVPNSIGKS 496
PV +G+S
Sbjct: 715 SPVLEPVGRS 724
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 188 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 244
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 62 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 120
Query: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 121 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 179
Query: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 180 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 239
Query: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 240 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 299
Query: 425 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 359
Query: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
FT +S G P + A F GFS+
Sbjct: 360 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 386
Score = 121 bits (303), Expect = 2e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 151 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 210
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 385 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 440
Query: 211 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 270
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 441 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 493
Query: 271 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 329
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 494 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 553
Query: 330 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 554 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 613
Query: 387 YGLPPF 392
G PF
Sbjct: 614 AGFTPF 619
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 283 bits (725), Expect = 2e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 188 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 244
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
Query: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
Query: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
Query: 425 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
Query: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
FT +S G P + A F GFS+
Sbjct: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
Score = 121 bits (303), Expect = 2e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 151 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 210
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
Query: 211 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 270
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
Query: 271 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 329
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
Query: 330 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
Query: 387 YGLPPF 392
G PF
Sbjct: 606 AGFTPF 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,122,418
Number of Sequences: 37866
Number of extensions: 1155697
Number of successful extensions: 7183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 4671
Number of HSP's gapped (non-prelim): 1145
length of query: 526
length of database: 18,247,518
effective HSP length: 107
effective length of query: 419
effective length of database: 14,195,856
effective search space: 5948063664
effective search space used: 5948063664
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.