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Search of human proteins with 218505706
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform
1 [Homo sapiens]
(423 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 859 0.0
gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2 ... 602 e-172
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 456 e-128
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 282 4e-76
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 139 5e-33
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 139 5e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 116 3e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 116 3e-26
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 116 3e-26
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 116 3e-26
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 116 3e-26
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 116 4e-26
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 116 4e-26
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 116 4e-26
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 108 7e-24
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 105 6e-23
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 104 1e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 102 7e-22
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 100 2e-21
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 100 2e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 99 7e-21
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 99 9e-21
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 99 9e-21
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 97 3e-20
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 96 5e-20
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 96 5e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 95 1e-19
gi|16975496 cortactin binding protein 2 [Homo sapiens] 94 2e-19
gi|34304381 inversin isoform a [Homo sapiens] 93 5e-19
gi|34304379 inversin isoform b [Homo sapiens] 93 5e-19
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 859 bits (2220), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA
Sbjct: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML
Sbjct: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISL 240
DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISL
Sbjct: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISL 240
Query: 241 LLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYT 300
LLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYT
Sbjct: 241 LLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYT 300
Query: 301 VEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEI 360
VEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEI
Sbjct: 301 VEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEI 360
Query: 361 HFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFT 420
HFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFT
Sbjct: 361 HFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFT 420
Query: 421 GTW 423
GTW
Sbjct: 421 GTW 423
>gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2
[Homo sapiens]
Length = 302
Score = 602 bits (1552), Expect = e-172
Identities = 292/293 (99%), Positives = 292/293 (99%)
Query: 131 LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
L ALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD
Sbjct: 10 LRALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 69
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY 250
HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY
Sbjct: 70 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY 129
Query: 251 FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 310
FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK
Sbjct: 130 FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIK 189
Query: 311 DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL 370
DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL
Sbjct: 190 DTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSL 249
Query: 371 KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW 423
KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
Sbjct: 250 KHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW 302
Score = 34.7 bits (78), Expect = 0.17
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 12/85 (14%)
Query: 4 LLINYGADVNLRCA---------NERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFT 54
LLI G DVN + ++AL+ A VKL+L +GA P+
Sbjct: 47 LLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---N 103
Query: 55 PLALAAQSGHTEIMEMLLRKGANAH 79
L +A + G+ E++ +LLR GAN +
Sbjct: 104 CLQIALRMGNYELISLLLRHGANVN 128
Score = 31.2 bits (69), Expect = 1.9
Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 20/134 (14%)
Query: 92 AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIK---Q 148
AA+G +P + LL++ G D N + I+ D AL + +DL+++K
Sbjct: 36 AAAGAHPQCLELLIQAGFDVNFMLDQ---RINKHYDDHRKSALYFAVSNSDLSSVKLLLS 92
Query: 149 SGI----SPVHC---AAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 201
+G PV+C A + + + LL++ G +VN+ R+N H SAL + +
Sbjct: 93 AGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFC--RVNPL---HFPSALQYTL- 146
Query: 202 NSDLSSVKLLLSAG 215
D +++LL+ G
Sbjct: 147 -KDEVMLRMLLNYG 159
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 456 bits (1172), Expect = e-128
Identities = 226/425 (53%), Positives = 293/425 (68%), Gaps = 9/425 (2%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M + LI + ++ C +A+HEAAK GR+D+V L+L G + + +G TPL +AA
Sbjct: 159 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAA 218
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH +++E L+ KG + A D +S+L EAA GGNPD ++LLLEYG N+P +GHL
Sbjct: 219 EYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHL 278
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
PIH AA GH LALK LIPVT AI++SG++P+H AA G + QCLELLI+ GFDVN +L
Sbjct: 279 PIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLL 338
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISL 240
I++ YDD RK+ALYF VSN+D+ ++LL+AGA PN DP+NCL +A+R NYE++ L
Sbjct: 339 ADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRL 398
Query: 241 LLRHGANVN-YFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSY 299
LL HGANVN YF VN FPS +QY L DEVMLR+LLN GY E CFDC HGD S+
Sbjct: 399 LLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSF 458
Query: 300 --------TVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVL 351
+ GWTS VIKD FCE IT+ W++HL G+V RV++DY+D V +C+KLK+ L
Sbjct: 459 VWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSAL 518
Query: 352 QKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEY 411
+ Q W EI IL NP SLKHLCRLKIR+ MG L P + LPLP ++ Y+L+KEY
Sbjct: 519 EVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEY 578
Query: 412 DLYGQ 416
DLYGQ
Sbjct: 579 DLYGQ 583
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 282 bits (722), Expect = 4e-76
Identities = 152/413 (36%), Positives = 240/413 (58%), Gaps = 10/413 (2%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ + AD N RC TALHE+ +++++++ GA + ++ YG TPL +AAQSG
Sbjct: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSG 234
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E + L + GA+ + QASD++S L EA + + V LL GADAN G LP+H
Sbjct: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
Query: 124 VAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
+A+ +G+ +++L+PVT I++SG+SP+H AA H + LE L+ A FDVN L
Sbjct: 295 IASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPE 354
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLR 243
+ Y+D R SALYFAV N+++ + +LLL GA PN+D ++ L +A+R G + LLL
Sbjct: 355 RARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLD 414
Query: 244 HGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHP--SYTV 301
HGAN++ + +P FP+ + + +K +L+ L++ G D E CF C +G+ HP
Sbjct: 415 HGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPS 474
Query: 302 EGWTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGI 356
+ D +FCE ++ + +G ++ V+LDYV V++CS+LK +
Sbjct: 475 SRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFED 534
Query: 357 WSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYK 409
W+ I PR L HLCRL++RK +G+ ++ + LPLP RL Y+ Y+
Sbjct: 535 WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYE 584
Score = 58.2 bits (139), Expect = 1e-08
Identities = 61/230 (26%), Positives = 103/230 (44%), Gaps = 39/230 (16%)
Query: 89 LLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKIL---IPVT-DLA 144
L++A G+ +A+ +++ G + P G LP+H AA G + LK+L P T D
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 145 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHY---------------- 188
+++ + V+ A H CL L+QAG + + R Y
Sbjct: 121 TLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
Query: 189 ----DDHR----KSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+HR +AL+ +VS +DL +++L+S GA N + L +A + G E
Sbjct: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
Query: 238 ISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTER 285
+ L ++GA++N N SAL K+ E ++ LL+ G D +
Sbjct: 239 LRFLAKYGADINTQASDN----ASALYEACKNEHEEVVEFLLSQGADANK 284
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 139 bits (350), Expect = 5e-33
Identities = 125/419 (29%), Positives = 194/419 (46%), Gaps = 58/419 (13%)
Query: 4 LLINYGADVN---LRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
LL+ +GA+VN C +LH+A+ +++KL+L GA+ + Q +G TPL +AA
Sbjct: 57 LLLQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 114
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN--SG 118
Q G E + +L+ GAN + QA D ++ L AA G+ V LLL GAD ++ N S
Sbjct: 115 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 174
Query: 119 HLPIHVAADRGHLLALKILIPVTDLAA-IKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
LPIH AA GH L +LIP+T+ A + +SPV+ A G H CLE+L++ G
Sbjct: 175 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---- 230
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYEL 237
Y ++ L F S+ PV C+ + +
Sbjct: 231 ----------YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGI 260
Query: 238 ISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKV 295
+++LL++GA ++N LH L+Y LR + G H K
Sbjct: 261 VNILLKYGA------QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 314
Query: 296 HPSYTVEGWTSTVIKDTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQK 353
Y + W ++ F +I L SW+ +S + L++ + + ++ +L
Sbjct: 315 QAKY--KEWLPHLLV-AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSA 371
Query: 354 QG--IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 410
+ W I T P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 372 RASNAWILQQHIATVP-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
Score = 57.0 bits (136), Expect = 3e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGF--TPLALAA 60
++LI+ GA+VN + ++ T L AA+ G V+L+L SGA PD P+ AA
Sbjct: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 182
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG 108
Q GHT+I+++L+ A + S + A GG+ D + +LL G
Sbjct: 183 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 139 bits (350), Expect = 5e-33
Identities = 125/419 (29%), Positives = 194/419 (46%), Gaps = 58/419 (13%)
Query: 4 LLINYGADVN---LRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
LL+ +GA+VN C +LH+A+ +++KL+L GA+ + Q +G TPL +AA
Sbjct: 130 LLLQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 187
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN--SG 118
Q G E + +L+ GAN + QA D ++ L AA G+ V LLL GAD ++ N S
Sbjct: 188 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 247
Query: 119 HLPIHVAADRGHLLALKILIPVTDLAA-IKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
LPIH AA GH L +LIP+T+ A + +SPV+ A G H CLE+L++ G
Sbjct: 248 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---- 303
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYEL 237
Y ++ L F S+ PV C+ + +
Sbjct: 304 ----------YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGI 333
Query: 238 ISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKV 295
+++LL++GA ++N LH L+Y LR + G H K
Sbjct: 334 VNILLKYGA------QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
Query: 296 HPSYTVEGWTSTVIKDTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQK 353
Y + W ++ F +I L SW+ +S + L++ + + ++ +L
Sbjct: 388 QAKY--KEWLPHLLV-AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSA 444
Query: 354 QG--IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 410
+ W I T P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 445 RASNAWILQQHIATVP-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
Score = 65.1 bits (157), Expect = 1e-10
Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 42/277 (15%)
Query: 43 AHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVA 102
A+ D ST G LAA+ G+ +++ LL+KG + + + EAA + + +
Sbjct: 6 AYADTCSTVG-----LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 103 LLLEYGADANIPKN---SGHLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAA 158
+L+ + N K G +H+AA +GH ++IL+ D A +P+ A
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
Query: 159 AGAHPQCLELLIQAGFDVN------------------------FMLDQRINKH-YDDHRK 193
L LL+Q G +VN +L + NK DD
Sbjct: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
Query: 194 SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNY 250
+ L+ A L S+ +L+S+GA N D L IA + G+ + + LLL GA+ +
Sbjct: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 251 FCRVN----PLHFPSALQYTLKDEVMLRMLLNYGYDT 283
+C + P+H + + +T K +L L N DT
Sbjct: 241 YCNEDSWQLPIHAAAQMGHT-KILDLLIPLTNRACDT 276
Score = 57.0 bits (136), Expect = 3e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGF--TPLALAA 60
++LI+ GA+VN + ++ T L AA+ G V+L+L SGA PD P+ AA
Sbjct: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG 108
Q GHT+I+++L+ A + S + A GG+ D + +LL G
Sbjct: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 116 bits (291), Expect = 3e-26
Identities = 85/261 (32%), Positives = 131/261 (50%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GA ++ + T LH A+ +G +VK +L GA P+ + TPL +AA++G
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 481
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
HTE+ + LL+ A + +A D + L AA G+ + V LLLE A+ N+ +GH P+H
Sbjct: 482 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 541
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH+ L +L A + + G +P+H AA + ELL++ N
Sbjct: 542 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA--- 598
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELIS 239
+ + L+ AV +++L VKLLL G P+ N L IA + E+
Sbjct: 599 ------GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 652
Query: 240 LLLRHG--ANVNYFCRVNPLH 258
LL++G AN V PLH
Sbjct: 653 SLLQYGGSANAESVQGVTPLH 673
Score = 116 bits (290), Expect = 4e-26
Identities = 92/282 (32%), Positives = 139/282 (49%), Gaps = 21/282 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA VN N T LH A++ G MV+L+L GA + ++ TPL AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
++GH I E+LL GA + + S + AA G + D V LLL+Y A+ +
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 373
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQS----GISPVHCAAAGAHPQCLELLIQAGFDV 176
P+HVAA GH K+L+ D A S G +P+H A H + +ELL++ G +
Sbjct: 374 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 430
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMG 233
+ + + + + L+ A L VK LL GA PN V L +A R G
Sbjct: 431 DAVTESGL---------TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 481
Query: 234 NYELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVML 273
+ E+ LL++ A VN + PLH + + +T +++L
Sbjct: 482 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523
Score = 105 bits (263), Expect = 6e-23
Identities = 82/267 (30%), Positives = 127/267 (47%), Gaps = 15/267 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A L+ A VN + +++T LH AA++G +MVKL+L + A+P+ +T G TPL +AA
Sbjct: 485 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 544
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH E + LL K A+ + L AA G LLLE A N +G
Sbjct: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 604
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+HVA +L +K+L+P + +G +P+H AA + L+Q G N
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA---GALPNQDPVNCLQIALRMGNYE 236
Q + + L+ A V LLLS G L N+ + L + + G+
Sbjct: 665 SVQGV---------TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 237 LISLLLRHGANVNYFCRV--NPLHFPS 261
+ +L++HG V+ R+ PLH S
Sbjct: 716 VADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 101 bits (252), Expect = 1e-21
Identities = 84/268 (31%), Positives = 132/268 (49%), Gaps = 29/268 (10%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
TALH AA G++++V+ ++ GA+ + QS GFTPL +AAQ H E+++ LL GAN +
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IHVAADRGHLLALKILI- 138
D + L A G+ + VA L+ YG K LP +H+AA +L+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 227
Query: 139 --PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
P D+ + ++G +P+H AA + +LL+ G VNF I + L
Sbjct: 228 NDPNPDV--LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPL 276
Query: 197 YFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 253
+ A ++ V+LLL GA +D + L A R G+ + +LL HGA + +
Sbjct: 277 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 336
Query: 254 --VNPLHFPSALQYTLKDEVMLRMLLNY 279
++P+H A Q D +R+LL Y
Sbjct: 337 NGLSPIHM--AAQGDHLD--CVRLLLQY 360
Score = 99.8 bits (247), Expect = 4e-21
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 77/325 (23%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+NYGA+VN + T L+ AA+ ++VK +L +GA+ + + GFTPLA+A Q GH
Sbjct: 130 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 189
Query: 65 TEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AASG 95
++ L+ G A + ++++LL+ AA
Sbjct: 190 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 249
Query: 96 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI---------------PV 140
N + LLL GA N +G P+H+A+ RG+++ +++L+ P+
Sbjct: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
Query: 141 -------------------TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 181
+ A ++G+SP+H AA G H C+ LL+Q D
Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YD 361
Query: 182 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELI 238
I+ DH + L+ A K+LL GA PN +N L IA + + ++
Sbjct: 362 AEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 239 SLLLRHGANVNYFCR--VNPLHFPS 261
LLL+ GA+++ + PLH S
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVAS 445
Score = 99.8 bits (247), Expect = 4e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+ A N N T LH A D+VKL+L G P + G+TPL +AA
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 643
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ E+ LL+ G +A+ ++ + L AA G+ + VALLL A+ N+ SG
Sbjct: 644 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+ A GH+ +LI + A + G +P+H A+ + + ++ L+Q DVN
Sbjct: 704 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-- 761
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYE 236
+ Y S L+ A V LLL GA PN+ D L IA R+G
Sbjct: 762 --AKTKLGY-----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 814
Query: 237 LISLL 241
+ +L
Sbjct: 815 VTDVL 819
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T LH AAK G+ + +L+L AHP+ G TPL +A + +I+++LL +G + H
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV 140
A + + L AA + LL+YG AN G P+H+AA GH + +L+
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 141 TDLAAI-KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 199
+ +SG++P+H A H ++LI+ G M+D Y + L+ A
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV----MVDATTRMGY-----TPLHVA 741
Query: 200 VSNSDLSSVKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 249
++ VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ Y A+++ + T LH AA G + K++L GA P+ ++ GFTPL +A +
Sbjct: 356 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +ME+LL+ GA+ + L A+ G+ V LL+ GA N+ P+H
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 475
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH K L+ + A + +P+HCAA H ++LL++ + N
Sbjct: 476 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 535
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELIS 239
+ L+ A + +V LL ++ A + L +A + G +
Sbjct: 536 ---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 586
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL A+ N + + PLH
Sbjct: 587 LLLERDAHPNAAGKNGLTPLH 607
Score = 82.8 bits (203), Expect = 5e-16
Identities = 71/271 (26%), Positives = 128/271 (47%), Gaps = 15/271 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AA+L+ + ++ T LH AA ++ +L+L GA + G TPL +A++
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++ +LL +GA + D + L AA G+ +LL++GA +G P
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
IH+AA HL +++L+ ++ I ++P+H AA H + ++L+ G N
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN--- 398
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+ +N + L+ A + + ++LLL GA + + L +A MG+ +
Sbjct: 399 SRALNGF------TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 238 ISLLLRHGA--NVNYFCRVNPLHFPSALQYT 266
+ LL+ GA NV+ PLH + +T
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHT 483
Score = 77.4 bits (189), Expect = 2e-14
Identities = 74/276 (26%), Positives = 115/276 (41%), Gaps = 27/276 (9%)
Query: 17 ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 76
A+ T+ AA+ G D L +G + + G L LA++ GH +++ LL K
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
Query: 77 NAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKI 136
++ L AA G + V L+ YGA+ N G P+++AA HL +K
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 137 LIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSA 195
L+ + + G +P+ A H + LI G R A
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV-------------RLPA 209
Query: 196 LYFAVSNSDLSSVKLLLSAGALPNQDPVN-----CLQIALRMGNYELISLLLRHGANVNY 250
L+ A N D + +LL PN D ++ L IA N + LLL GA+VN+
Sbjct: 210 LHIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF 267
Query: 251 FCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
+ + PLH S + +M+R+LL+ G E
Sbjct: 268 TPQNGITPLHIAS----RRGNVIMVRLLLDRGAQIE 299
Score = 70.5 bits (171), Expect = 3e-12
Identities = 44/142 (30%), Positives = 75/142 (52%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M ALL++ A+ NL + T LH A+ G + +++ G D + G+TPL +A+
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ ++++ LL+ A+ + + S L +AA G+ D V LLL+ GA N + G
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802
Query: 121 PIHVAADRGHLLALKILIPVTD 142
P+ +A G++ +L VTD
Sbjct: 803 PLAIAKRLGYISVTDVLKVVTD 824
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 116 bits (291), Expect = 3e-26
Identities = 85/261 (32%), Positives = 131/261 (50%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GA ++ + T LH A+ +G +VK +L GA P+ + TPL +AA++G
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
HTE+ + LL+ A + +A D + L AA G+ + V LLLE A+ N+ +GH P+H
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH+ L +L A + + G +P+H AA + ELL++ N
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA--- 565
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELIS 239
+ + L+ AV +++L VKLLL G P+ N L IA + E+
Sbjct: 566 ------GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 240 LLLRHG--ANVNYFCRVNPLH 258
LL++G AN V PLH
Sbjct: 620 SLLQYGGSANAESVQGVTPLH 640
Score = 116 bits (290), Expect = 4e-26
Identities = 92/282 (32%), Positives = 139/282 (49%), Gaps = 21/282 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA VN N T LH A++ G MV+L+L GA + ++ TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
++GH I E+LL GA + + S + AA G + D V LLL+Y A+ +
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQS----GISPVHCAAAGAHPQCLELLIQAGFDV 176
P+HVAA GH K+L+ D A S G +P+H A H + +ELL++ G +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMG 233
+ + + + + L+ A L VK LL GA PN V L +A R G
Sbjct: 398 DAVTESGL---------TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 234 NYELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVML 273
+ E+ LL++ A VN + PLH + + +T +++L
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Score = 105 bits (263), Expect = 6e-23
Identities = 82/267 (30%), Positives = 127/267 (47%), Gaps = 15/267 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A L+ A VN + +++T LH AA++G +MVKL+L + A+P+ +T G TPL +AA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH E + LL K A+ + L AA G LLLE A N +G
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+HVA +L +K+L+P + +G +P+H AA + L+Q G N
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA---GALPNQDPVNCLQIALRMGNYE 236
Q + + L+ A V LLLS G L N+ + L + + G+
Sbjct: 632 SVQGV---------TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 237 LISLLLRHGANVNYFCRV--NPLHFPS 261
+ +L++HG V+ R+ PLH S
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 101 bits (252), Expect = 1e-21
Identities = 84/268 (31%), Positives = 132/268 (49%), Gaps = 29/268 (10%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
TALH AA G++++V+ ++ GA+ + QS GFTPL +AAQ H E+++ LL GAN +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IHVAADRGHLLALKILI- 138
D + L A G+ + VA L+ YG K LP +H+AA +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 139 --PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
P D+ + ++G +P+H AA + +LL+ G VNF I + L
Sbjct: 195 NDPNPDV--LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPL 243
Query: 197 YFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 253
+ A ++ V+LLL GA +D + L A R G+ + +LL HGA + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 254 --VNPLHFPSALQYTLKDEVMLRMLLNY 279
++P+H A Q D +R+LL Y
Sbjct: 304 NGLSPIHM--AAQGDHLD--CVRLLLQY 327
Score = 99.8 bits (247), Expect = 4e-21
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 77/325 (23%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+NYGA+VN + T L+ AA+ ++VK +L +GA+ + + GFTPLA+A Q GH
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
Query: 65 TEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AASG 95
++ L+ G A + ++++LL+ AA
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 216
Query: 96 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI---------------PV 140
N + LLL GA N +G P+H+A+ RG+++ +++L+ P+
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 141 -------------------TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 181
+ A ++G+SP+H AA G H C+ LL+Q D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YD 328
Query: 182 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELI 238
I+ DH + L+ A K+LL GA PN +N L IA + + ++
Sbjct: 329 AEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 239 SLLLRHGANVNYFCR--VNPLHFPS 261
LLL+ GA+++ + PLH S
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVAS 412
Score = 99.8 bits (247), Expect = 4e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+ A N N T LH A D+VKL+L G P + G+TPL +AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ E+ LL+ G +A+ ++ + L AA G+ + VALLL A+ N+ SG
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+ A GH+ +LI + A + G +P+H A+ + + ++ L+Q DVN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-- 728
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYE 236
+ Y S L+ A V LLL GA PN+ D L IA R+G
Sbjct: 729 --AKTKLGY-----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 237 LISLL 241
+ +L
Sbjct: 782 VTDVL 786
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T LH AAK G+ + +L+L AHP+ G TPL +A + +I+++LL +G + H
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV 140
A + + L AA + LL+YG AN G P+H+AA GH + +L+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 141 TDLAAI-KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 199
+ +SG++P+H A H ++LI+ G M+D Y + L+ A
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV----MVDATTRMGY-----TPLHVA 708
Query: 200 VSNSDLSSVKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 249
++ VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ Y A+++ + T LH AA G + K++L GA P+ ++ GFTPL +A +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +ME+LL+ GA+ + L A+ G+ V LL+ GA N+ P+H
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH K L+ + A + +P+HCAA H ++LL++ + N
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELIS 239
+ L+ A + +V LL ++ A + L +A + G +
Sbjct: 503 ---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL A+ N + + PLH
Sbjct: 554 LLLERDAHPNAAGKNGLTPLH 574
Score = 82.8 bits (203), Expect = 5e-16
Identities = 71/271 (26%), Positives = 128/271 (47%), Gaps = 15/271 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AA+L+ + ++ T LH AA ++ +L+L GA + G TPL +A++
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++ +LL +GA + D + L AA G+ +LL++GA +G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
IH+AA HL +++L+ ++ I ++P+H AA H + ++L+ G N
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN--- 365
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+ +N + L+ A + + ++LLL GA + + L +A MG+ +
Sbjct: 366 SRALNGF------TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 238 ISLLLRHGA--NVNYFCRVNPLHFPSALQYT 266
+ LL+ GA NV+ PLH + +T
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Score = 79.3 bits (194), Expect = 6e-15
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 27/281 (9%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
V R A+ T+ AA+ G D L +G + + G L LA++ GH +++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 72 LRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL 131
L K ++ L AA G + V L+ YGA+ N G P+++AA HL
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 132 LALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+K L+ + + G +P+ A H + LI G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------------ 172
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN-----CLQIALRMGNYELISLLLRHG 245
R AL+ A N D + +LL PN D ++ L IA N + LLL G
Sbjct: 173 -RLPALHIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 246 ANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
A+VN+ + + PLH S + +M+R+LL+ G E
Sbjct: 230 ASVNFTPQNGITPLHIAS----RRGNVIMVRLLLDRGAQIE 266
Score = 70.5 bits (171), Expect = 3e-12
Identities = 44/142 (30%), Positives = 75/142 (52%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M ALL++ A+ NL + T LH A+ G + +++ G D + G+TPL +A+
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ ++++ LL+ A+ + + S L +AA G+ D V LLL+ GA N + G
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 121 PIHVAADRGHLLALKILIPVTD 142
P+ +A G++ +L VTD
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTD 791
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 116 bits (291), Expect = 3e-26
Identities = 85/261 (32%), Positives = 131/261 (50%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GA ++ + T LH A+ +G +VK +L GA P+ + TPL +AA++G
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
HTE+ + LL+ A + +A D + L AA G+ + V LLLE A+ N+ +GH P+H
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH+ L +L A + + G +P+H AA + ELL++ N
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA--- 565
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELIS 239
+ + L+ AV +++L VKLLL G P+ N L IA + E+
Sbjct: 566 ------GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 240 LLLRHG--ANVNYFCRVNPLH 258
LL++G AN V PLH
Sbjct: 620 SLLQYGGSANAESVQGVTPLH 640
Score = 116 bits (290), Expect = 4e-26
Identities = 92/282 (32%), Positives = 139/282 (49%), Gaps = 21/282 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA VN N T LH A++ G MV+L+L GA + ++ TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
++GH I E+LL GA + + S + AA G + D V LLL+Y A+ +
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQS----GISPVHCAAAGAHPQCLELLIQAGFDV 176
P+HVAA GH K+L+ D A S G +P+H A H + +ELL++ G +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMG 233
+ + + + + L+ A L VK LL GA PN V L +A R G
Sbjct: 398 DAVTESGL---------TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 234 NYELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVML 273
+ E+ LL++ A VN + PLH + + +T +++L
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Score = 105 bits (263), Expect = 6e-23
Identities = 82/267 (30%), Positives = 127/267 (47%), Gaps = 15/267 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A L+ A VN + +++T LH AA++G +MVKL+L + A+P+ +T G TPL +AA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH E + LL K A+ + L AA G LLLE A N +G
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+HVA +L +K+L+P + +G +P+H AA + L+Q G N
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA---GALPNQDPVNCLQIALRMGNYE 236
Q + + L+ A V LLLS G L N+ + L + + G+
Sbjct: 632 SVQGV---------TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 237 LISLLLRHGANVNYFCRV--NPLHFPS 261
+ +L++HG V+ R+ PLH S
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 101 bits (252), Expect = 1e-21
Identities = 84/268 (31%), Positives = 132/268 (49%), Gaps = 29/268 (10%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
TALH AA G++++V+ ++ GA+ + QS GFTPL +AAQ H E+++ LL GAN +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IHVAADRGHLLALKILI- 138
D + L A G+ + VA L+ YG K LP +H+AA +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 139 --PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
P D+ + ++G +P+H AA + +LL+ G VNF I + L
Sbjct: 195 NDPNPDV--LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPL 243
Query: 197 YFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 253
+ A ++ V+LLL GA +D + L A R G+ + +LL HGA + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 254 --VNPLHFPSALQYTLKDEVMLRMLLNY 279
++P+H A Q D +R+LL Y
Sbjct: 304 NGLSPIHM--AAQGDHLD--CVRLLLQY 327
Score = 99.8 bits (247), Expect = 4e-21
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 77/325 (23%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+NYGA+VN + T L+ AA+ ++VK +L +GA+ + + GFTPLA+A Q GH
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
Query: 65 TEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AASG 95
++ L+ G A + ++++LL+ AA
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 216
Query: 96 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI---------------PV 140
N + LLL GA N +G P+H+A+ RG+++ +++L+ P+
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 141 -------------------TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 181
+ A ++G+SP+H AA G H C+ LL+Q D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YD 328
Query: 182 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELI 238
I+ DH + L+ A K+LL GA PN +N L IA + + ++
Sbjct: 329 AEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 239 SLLLRHGANVNYFCR--VNPLHFPS 261
LLL+ GA+++ + PLH S
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVAS 412
Score = 99.8 bits (247), Expect = 4e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+ A N N T LH A D+VKL+L G P + G+TPL +AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ E+ LL+ G +A+ ++ + L AA G+ + VALLL A+ N+ SG
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+ A GH+ +LI + A + G +P+H A+ + + ++ L+Q DVN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-- 728
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYE 236
+ Y S L+ A V LLL GA PN+ D L IA R+G
Sbjct: 729 --AKTKLGY-----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 237 LISLL 241
+ +L
Sbjct: 782 VTDVL 786
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T LH AAK G+ + +L+L AHP+ G TPL +A + +I+++LL +G + H
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV 140
A + + L AA + LL+YG AN G P+H+AA GH + +L+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 141 TDLAAI-KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 199
+ +SG++P+H A H ++LI+ G M+D Y + L+ A
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV----MVDATTRMGY-----TPLHVA 708
Query: 200 VSNSDLSSVKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 249
++ VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ Y A+++ + T LH AA G + K++L GA P+ ++ GFTPL +A +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +ME+LL+ GA+ + L A+ G+ V LL+ GA N+ P+H
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH K L+ + A + +P+HCAA H ++LL++ + N
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELIS 239
+ L+ A + +V LL ++ A + L +A + G +
Sbjct: 503 ---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL A+ N + + PLH
Sbjct: 554 LLLERDAHPNAAGKNGLTPLH 574
Score = 82.8 bits (203), Expect = 5e-16
Identities = 71/271 (26%), Positives = 128/271 (47%), Gaps = 15/271 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AA+L+ + ++ T LH AA ++ +L+L GA + G TPL +A++
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++ +LL +GA + D + L AA G+ +LL++GA +G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
IH+AA HL +++L+ ++ I ++P+H AA H + ++L+ G N
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN--- 365
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+ +N + L+ A + + ++LLL GA + + L +A MG+ +
Sbjct: 366 SRALNGF------TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 238 ISLLLRHGA--NVNYFCRVNPLHFPSALQYT 266
+ LL+ GA NV+ PLH + +T
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Score = 79.3 bits (194), Expect = 6e-15
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 27/281 (9%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
V R A+ T+ AA+ G D L +G + + G L LA++ GH +++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 72 LRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL 131
L K ++ L AA G + V L+ YGA+ N G P+++AA HL
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 132 LALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+K L+ + + G +P+ A H + LI G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------------ 172
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN-----CLQIALRMGNYELISLLLRHG 245
R AL+ A N D + +LL PN D ++ L IA N + LLL G
Sbjct: 173 -RLPALHIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 246 ANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
A+VN+ + + PLH S + +M+R+LL+ G E
Sbjct: 230 ASVNFTPQNGITPLHIAS----RRGNVIMVRLLLDRGAQIE 266
Score = 70.5 bits (171), Expect = 3e-12
Identities = 44/142 (30%), Positives = 75/142 (52%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M ALL++ A+ NL + T LH A+ G + +++ G D + G+TPL +A+
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ ++++ LL+ A+ + + S L +AA G+ D V LLL+ GA N + G
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 121 PIHVAADRGHLLALKILIPVTD 142
P+ +A G++ +L VTD
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTD 791
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 116 bits (291), Expect = 3e-26
Identities = 85/261 (32%), Positives = 131/261 (50%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GA ++ + T LH A+ +G +VK +L GA P+ + TPL +AA++G
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
HTE+ + LL+ A + +A D + L AA G+ + V LLLE A+ N+ +GH P+H
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH+ L +L A + + G +P+H AA + ELL++ N
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA--- 565
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELIS 239
+ + L+ AV +++L VKLLL G P+ N L IA + E+
Sbjct: 566 ------GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 240 LLLRHG--ANVNYFCRVNPLH 258
LL++G AN V PLH
Sbjct: 620 SLLQYGGSANAESVQGVTPLH 640
Score = 116 bits (290), Expect = 4e-26
Identities = 92/282 (32%), Positives = 139/282 (49%), Gaps = 21/282 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA VN N T LH A++ G MV+L+L GA + ++ TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
++GH I E+LL GA + + S + AA G + D V LLL+Y A+ +
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQS----GISPVHCAAAGAHPQCLELLIQAGFDV 176
P+HVAA GH K+L+ D A S G +P+H A H + +ELL++ G +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMG 233
+ + + + + L+ A L VK LL GA PN V L +A R G
Sbjct: 398 DAVTESGL---------TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 234 NYELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVML 273
+ E+ LL++ A VN + PLH + + +T +++L
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Score = 105 bits (263), Expect = 6e-23
Identities = 82/267 (30%), Positives = 127/267 (47%), Gaps = 15/267 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A L+ A VN + +++T LH AA++G +MVKL+L + A+P+ +T G TPL +AA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH E + LL K A+ + L AA G LLLE A N +G
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+HVA +L +K+L+P + +G +P+H AA + L+Q G N
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA---GALPNQDPVNCLQIALRMGNYE 236
Q + + L+ A V LLLS G L N+ + L + + G+
Sbjct: 632 SVQGV---------TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 237 LISLLLRHGANVNYFCRV--NPLHFPS 261
+ +L++HG V+ R+ PLH S
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 101 bits (252), Expect = 1e-21
Identities = 84/268 (31%), Positives = 132/268 (49%), Gaps = 29/268 (10%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
TALH AA G++++V+ ++ GA+ + QS GFTPL +AAQ H E+++ LL GAN +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IHVAADRGHLLALKILI- 138
D + L A G+ + VA L+ YG K LP +H+AA +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 139 --PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
P D+ + ++G +P+H AA + +LL+ G VNF I + L
Sbjct: 195 NDPNPDV--LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPL 243
Query: 197 YFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 253
+ A ++ V+LLL GA +D + L A R G+ + +LL HGA + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 254 --VNPLHFPSALQYTLKDEVMLRMLLNY 279
++P+H A Q D +R+LL Y
Sbjct: 304 NGLSPIHM--AAQGDHLD--CVRLLLQY 327
Score = 99.8 bits (247), Expect = 4e-21
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 77/325 (23%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+NYGA+VN + T L+ AA+ ++VK +L +GA+ + + GFTPLA+A Q GH
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
Query: 65 TEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AASG 95
++ L+ G A + ++++LL+ AA
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 216
Query: 96 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI---------------PV 140
N + LLL GA N +G P+H+A+ RG+++ +++L+ P+
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 141 -------------------TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 181
+ A ++G+SP+H AA G H C+ LL+Q D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YD 328
Query: 182 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELI 238
I+ DH + L+ A K+LL GA PN +N L IA + + ++
Sbjct: 329 AEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 239 SLLLRHGANVNYFCR--VNPLHFPS 261
LLL+ GA+++ + PLH S
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVAS 412
Score = 99.8 bits (247), Expect = 4e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+ A N N T LH A D+VKL+L G P + G+TPL +AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ E+ LL+ G +A+ ++ + L AA G+ + VALLL A+ N+ SG
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+ A GH+ +LI + A + G +P+H A+ + + ++ L+Q DVN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-- 728
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYE 236
+ Y S L+ A V LLL GA PN+ D L IA R+G
Sbjct: 729 --AKTKLGY-----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 237 LISLL 241
+ +L
Sbjct: 782 VTDVL 786
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T LH AAK G+ + +L+L AHP+ G TPL +A + +I+++LL +G + H
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV 140
A + + L AA + LL+YG AN G P+H+AA GH + +L+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 141 TDLAAI-KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 199
+ +SG++P+H A H ++LI+ G M+D Y + L+ A
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV----MVDATTRMGY-----TPLHVA 708
Query: 200 VSNSDLSSVKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 249
++ VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ Y A+++ + T LH AA G + K++L GA P+ ++ GFTPL +A +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +ME+LL+ GA+ + L A+ G+ V LL+ GA N+ P+H
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH K L+ + A + +P+HCAA H ++LL++ + N
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELIS 239
+ L+ A + +V LL ++ A + L +A + G +
Sbjct: 503 ---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL A+ N + + PLH
Sbjct: 554 LLLERDAHPNAAGKNGLTPLH 574
Score = 82.8 bits (203), Expect = 5e-16
Identities = 71/271 (26%), Positives = 128/271 (47%), Gaps = 15/271 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AA+L+ + ++ T LH AA ++ +L+L GA + G TPL +A++
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++ +LL +GA + D + L AA G+ +LL++GA +G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
IH+AA HL +++L+ ++ I ++P+H AA H + ++L+ G N
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN--- 365
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+ +N + L+ A + + ++LLL GA + + L +A MG+ +
Sbjct: 366 SRALNGF------TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 238 ISLLLRHGA--NVNYFCRVNPLHFPSALQYT 266
+ LL+ GA NV+ PLH + +T
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Score = 79.3 bits (194), Expect = 6e-15
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 27/281 (9%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
V R A+ T+ AA+ G D L +G + + G L LA++ GH +++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 72 LRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL 131
L K ++ L AA G + V L+ YGA+ N G P+++AA HL
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 132 LALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+K L+ + + G +P+ A H + LI G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------------ 172
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN-----CLQIALRMGNYELISLLLRHG 245
R AL+ A N D + +LL PN D ++ L IA N + LLL G
Sbjct: 173 -RLPALHIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 246 ANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
A+VN+ + + PLH S + +M+R+LL+ G E
Sbjct: 230 ASVNFTPQNGITPLHIAS----RRGNVIMVRLLLDRGAQIE 266
Score = 70.5 bits (171), Expect = 3e-12
Identities = 44/142 (30%), Positives = 75/142 (52%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M ALL++ A+ NL + T LH A+ G + +++ G D + G+TPL +A+
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ ++++ LL+ A+ + + S L +AA G+ D V LLL+ GA N + G
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 121 PIHVAADRGHLLALKILIPVTD 142
P+ +A G++ +L VTD
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTD 791
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 116 bits (291), Expect = 3e-26
Identities = 85/261 (32%), Positives = 131/261 (50%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GA ++ + T LH A+ +G +VK +L GA P+ + TPL +AA++G
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
HTE+ + LL+ A + +A D + L AA G+ + V LLLE A+ N+ +GH P+H
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH+ L +L A + + G +P+H AA + ELL++ N
Sbjct: 509 IAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAA--- 565
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELIS 239
+ + L+ AV +++L VKLLL G P+ N L IA + E+
Sbjct: 566 ------GKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 240 LLLRHG--ANVNYFCRVNPLH 258
LL++G AN V PLH
Sbjct: 620 SLLQYGGSANAESVQGVTPLH 640
Score = 116 bits (290), Expect = 4e-26
Identities = 92/282 (32%), Positives = 139/282 (49%), Gaps = 21/282 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA VN N T LH A++ G MV+L+L GA + ++ TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
++GH I E+LL GA + + S + AA G + D V LLL+Y A+ +
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLT 340
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQS----GISPVHCAAAGAHPQCLELLIQAGFDV 176
P+HVAA GH K+L+ D A S G +P+H A H + +ELL++ G +
Sbjct: 341 PLHVAAHCGHHRVAKVLL---DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMG 233
+ + + + + L+ A L VK LL GA PN V L +A R G
Sbjct: 398 DAVTESGL---------TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 234 NYELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVML 273
+ E+ LL++ A VN + PLH + + +T +++L
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Score = 105 bits (263), Expect = 6e-23
Identities = 82/267 (30%), Positives = 127/267 (47%), Gaps = 15/267 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A L+ A VN + +++T LH AA++G +MVKL+L + A+P+ +T G TPL +AA
Sbjct: 452 VAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ GH E + LL K A+ + L AA G LLLE A N +G
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+HVA +L +K+L+P + +G +P+H AA + L+Q G N
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA---GALPNQDPVNCLQIALRMGNYE 236
Q + + L+ A V LLLS G L N+ + L + + G+
Sbjct: 632 SVQGV---------TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 237 LISLLLRHGANVNYFCRV--NPLHFPS 261
+ +L++HG V+ R+ PLH S
Sbjct: 683 VADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 101 bits (252), Expect = 1e-21
Identities = 84/268 (31%), Positives = 132/268 (49%), Gaps = 29/268 (10%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
TALH AA G++++V+ ++ GA+ + QS GFTPL +AAQ H E+++ LL GAN +
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IHVAADRGHLLALKILI- 138
D + L A G+ + VA L+ YG K LP +H+AA +L+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGT-----KGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 139 --PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
P D+ + ++G +P+H AA + +LL+ G VNF I + L
Sbjct: 195 NDPNPDV--LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI---------TPL 243
Query: 197 YFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR 253
+ A ++ V+LLL GA +D + L A R G+ + +LL HGA + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 254 --VNPLHFPSALQYTLKDEVMLRMLLNY 279
++P+H A Q D +R+LL Y
Sbjct: 304 NGLSPIHM--AAQGDHLD--CVRLLLQY 327
Score = 99.8 bits (247), Expect = 4e-21
Identities = 87/325 (26%), Positives = 143/325 (44%), Gaps = 77/325 (23%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+NYGA+VN + T L+ AA+ ++VK +L +GA+ + + GFTPLA+A Q GH
Sbjct: 97 LVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGH 156
Query: 65 TEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AASG 95
++ L+ G A + ++++LL+ AA
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHY 216
Query: 96 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI---------------PV 140
N + LLL GA N +G P+H+A+ RG+++ +++L+ P+
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Query: 141 -------------------TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLD 181
+ A ++G+SP+H AA G H C+ LL+Q D
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ--------YD 328
Query: 182 QRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYELI 238
I+ DH + L+ A K+LL GA PN +N L IA + + ++
Sbjct: 329 AEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 239 SLLLRHGANVNYFCR--VNPLHFPS 261
LLL+ GA+++ + PLH S
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVAS 412
Score = 99.8 bits (247), Expect = 4e-21
Identities = 77/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+ A N N T LH A D+VKL+L G P + G+TPL +AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ E+ LL+ G +A+ ++ + L AA G+ + VALLL A+ N+ SG
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670
Query: 121 PIHVAADRGHLLALKILIPVTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+ A GH+ +LI + A + G +P+H A+ + + ++ L+Q DVN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-- 728
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNYE 236
+ Y S L+ A V LLL GA PN+ D L IA R+G
Sbjct: 729 --AKTKLGY-----SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYIS 781
Query: 237 LISLL 241
+ +L
Sbjct: 782 VTDVL 786
Score = 96.7 bits (239), Expect = 4e-20
Identities = 69/233 (29%), Positives = 114/233 (48%), Gaps = 13/233 (5%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T LH AAK G+ + +L+L AHP+ G TPL +A + +I+++LL +G + H
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV 140
A + + L AA + LL+YG AN G P+H+AA GH + +L+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 141 TDLAAI-KQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFA 199
+ +SG++P+H A H ++LI+ G M+D Y + L+ A
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV----MVDATTRMGY-----TPLHVA 708
Query: 200 VSNSDLSSVKLLLSAGALPNQDP---VNCLQIALRMGNYELISLLLRHGANVN 249
++ VK LL A N + L A + G+ ++++LLL++GA+ N
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 15/261 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ Y A+++ + T LH AA G + K++L GA P+ ++ GFTPL +A +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +ME+LL+ GA+ + L A+ G+ V LL+ GA N+ P+H
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA GH K L+ + A + +P+HCAA H ++LL++ + N
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELIS 239
+ L+ A + +V LL ++ A + L +A + G +
Sbjct: 503 ---------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL A+ N + + PLH
Sbjct: 554 LLLERDAHPNAAGKNGLTPLH 574
Score = 82.8 bits (203), Expect = 5e-16
Identities = 71/271 (26%), Positives = 128/271 (47%), Gaps = 15/271 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AA+L+ + ++ T LH AA ++ +L+L GA + G TPL +A++
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++ +LL +GA + D + L AA G+ +LL++GA +G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
IH+AA HL +++L+ ++ I ++P+H AA H + ++L+ G N
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN--- 365
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYEL 237
+ +N + L+ A + + ++LLL GA + + L +A MG+ +
Sbjct: 366 SRALNGF------TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 238 ISLLLRHGA--NVNYFCRVNPLHFPSALQYT 266
+ LL+ GA NV+ PLH + +T
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Score = 79.3 bits (194), Expect = 6e-15
Identities = 76/281 (27%), Positives = 117/281 (41%), Gaps = 27/281 (9%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
V R A+ T+ AA+ G D L +G + + G L LA++ GH +++ L
Sbjct: 5 VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64
Query: 72 LRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL 131
L K ++ L AA G + V L+ YGA+ N G P+++AA HL
Sbjct: 65 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 132 LALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+K L+ + + G +P+ A H + LI G
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV------------ 172
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN-----CLQIALRMGNYELISLLLRHG 245
R AL+ A N D + +LL PN D ++ L IA N + LLL G
Sbjct: 173 -RLPALHIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 246 ANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
A+VN+ + + PLH S + +M+R+LL+ G E
Sbjct: 230 ASVNFTPQNGITPLHIAS----RRGNVIMVRLLLDRGAQIE 266
Score = 70.5 bits (171), Expect = 3e-12
Identities = 44/142 (30%), Positives = 75/142 (52%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M ALL++ A+ NL + T LH A+ G + +++ G D + G+TPL +A+
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ ++++ LL+ A+ + + S L +AA G+ D V LLL+ GA N + G
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 121 PIHVAADRGHLLALKILIPVTD 142
P+ +A G++ +L VTD
Sbjct: 770 PLAIAKRLGYISVTDVLKVVTD 791
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 116 bits (290), Expect = 4e-26
Identities = 89/280 (31%), Positives = 140/280 (50%), Gaps = 15/280 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA V+ N T LH A+K G +MVKL+L G D ++ G TPL AA
Sbjct: 227 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+SGH +++E+LL +GA + + S L AA G + + V LL++ A +
Sbjct: 287 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 346
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
+HVAA GH K+L+ + A +G +P+H A + +ELL++ G + +
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMGNYE 236
+ + + ++ A L+ V LLL GA P+ + L +A R G E
Sbjct: 407 TESGL---------TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457
Query: 237 LISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLR 274
++ LLR+GA V+ R PLH S L T +++L+
Sbjct: 458 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Score = 104 bits (260), Expect = 1e-22
Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 29/288 (10%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ YGA + + T +H AA +G ++V L+L +GA PD + G T L +AA++G
Sbjct: 395 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 454
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E++ LLR GA +A + + L A+ G + V LLL++ A + +G+ P+H
Sbjct: 455 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514
Query: 124 VAADRGHLLALKILIPVTDLAAI-KQSGISPVHCAAAGAHPQCLELLIQ--AGFD---VN 177
++A G + +L+ ++ + G +P+H AA +LL+Q A D N
Sbjct: 515 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 574
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGN 234
+ + HY D++K AL LLL GA P+ N L IA +
Sbjct: 575 GLTPLHVAAHY-DNQKVAL-------------LLLEKGASPHATAKNGYTPLHIAAKKNQ 620
Query: 235 YELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYG 280
++ S LL +GA N + V PLH S +T M+ +LL+ G
Sbjct: 621 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT----DMVTLLLDKG 664
Score = 100 bits (249), Expect = 2e-21
Identities = 81/287 (28%), Positives = 128/287 (44%), Gaps = 50/287 (17%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ GA++N + N T L+ AA+ D+VK +L +GA+ + GFTPLA+A Q G
Sbjct: 94 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 64 HTEIMEMLLRKGAN-----------AHGQASDSSSILLE--------------------- 91
H + + +LL A + S+++LL+
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213
Query: 92 -----AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLAA 145
AA GN + LLL GA + +G P+HVA+ RG+ +K+L+ + A
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 146 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 205
+ G++P+HCAA H Q +ELL++ G + + S L+ A +
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL---------SPLHMAAQGDHV 324
Query: 206 SSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN 249
VK LL A + D + L +A G+Y + LLL AN N
Sbjct: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371
Score = 100 bits (248), Expect = 3e-21
Identities = 78/255 (30%), Positives = 122/255 (47%), Gaps = 27/255 (10%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ G+ V+ TALH A+ G+ ++VK+++ GA+ + QS GFTPL +AAQ H
Sbjct: 62 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IH 123
++++ LL GAN D + L A G+ AVA+LLE N K LP +H
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALH 176
Query: 124 VAADRGHLLALKILIPVTDLAAIK---------QSGISPVHCAAAGAHPQCLELLIQAGF 174
+AA + + +L+ A ++ +SG +P+H AA + LL+ G
Sbjct: 177 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 236
Query: 175 DVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALR 231
V+F I + L+ A + + VKLLL G +D + L A R
Sbjct: 237 AVDFTARNGI---------TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287
Query: 232 MGNYELISLLLRHGA 246
G+ +++ LLL GA
Sbjct: 288 SGHDQVVELLLERGA 302
Score = 100 bits (248), Expect = 3e-21
Identities = 78/256 (30%), Positives = 119/256 (46%), Gaps = 19/256 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A++L+ GA +L T LH AAK G D+ KL+L A D G TPL +AA
Sbjct: 524 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ ++ +LL KGA+ H A + + L AA + LL YGA+ NI G
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+A+ GH + +L+ ++ +SG++ +H AA ++L + G D
Sbjct: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD---- 699
Query: 180 LDQRINKHYDDHRK---SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMG 233
D H K + L A ++ V LL GA N N L A + G
Sbjct: 700 --------QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 751
Query: 234 NYELISLLLRHGANVN 249
+ +I++LL+HGA N
Sbjct: 752 HTHIINVLLQHGAKPN 767
Score = 96.3 bits (238), Expect = 5e-20
Identities = 71/255 (27%), Positives = 126/255 (49%), Gaps = 9/255 (3%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIM 68
G D+N N ALH AAK G +V+ +L G+ D + G T L +A+ +G E++
Sbjct: 33 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92
Query: 69 EMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADR 128
++L+++GAN + Q+ + + L AA + D V LLE GA+ + G P+ VA +
Sbjct: 93 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 152
Query: 129 GHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHY 188
GH A+ IL+ ++ + +H AA + LL+Q + + +N+
Sbjct: 153 GHNQAVAILLENDTKGKVR---LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR-T 208
Query: 189 DDHRKSALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHG 245
+ + L+ A +++ LLL+ GA + ++ + L +A + GN ++ LLL G
Sbjct: 209 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 246 ANVNYFCR--VNPLH 258
++ R + PLH
Sbjct: 269 GQIDAKTRDGLTPLH 283
Score = 82.0 bits (201), Expect = 9e-16
Identities = 71/272 (26%), Positives = 126/272 (46%), Gaps = 13/272 (4%)
Query: 14 LRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLR 73
L+ ++ + AA+ G D V L G + + G L LAA+ GH +++ LL
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 74 KGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLA 133
+G++ ++ L A+ G + V +L++ GA+ N +G P+++AA H+
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 134 LKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ-RINKHYDDH 191
+K L+ + + + G +P+ A H Q + +L++ L I DD
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 184
Query: 192 RKSALYFAVS-NSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY 250
+ +AL N+D+ S K++++ P L IA GN + +LLL GA V++
Sbjct: 185 KSAALLLQNDHNADVQS-KMMVNRTTESGFTP---LHIAAHYGNVNVATLLLNRGAAVDF 240
Query: 251 FCR--VNPLHFPSALQYTLKDEVMLRMLLNYG 280
R + PLH S T M+++LL+ G
Sbjct: 241 TARNGITPLHVASKRGNT----NMVKLLLDRG 268
Score = 75.9 bits (185), Expect = 7e-14
Identities = 41/155 (26%), Positives = 84/155 (54%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M LL++ GA++++ + T+LH AA+ + ++ ++ GA D + G+TPL +A
Sbjct: 656 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 715
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ +++ LL++GAN + + + + L +AA G+ + +LL++GA N +G+
Sbjct: 716 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 775
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVH 155
+ +A G++ + L VT+ + I+ H
Sbjct: 776 ALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH 810
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 116 bits (290), Expect = 4e-26
Identities = 89/280 (31%), Positives = 140/280 (50%), Gaps = 15/280 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA V+ N T LH A+K G +MVKL+L G D ++ G TPL AA
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+SGH +++E+LL +GA + + S L AA G + + V LL++ A +
Sbjct: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
+HVAA GH K+L+ + A +G +P+H A + +ELL++ G + +
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMGNYE 236
+ + + ++ A L+ V LLL GA P+ + L +A R G E
Sbjct: 428 TESGL---------TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 237 LISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLR 274
++ LLR+GA V+ R PLH S L T +++L+
Sbjct: 479 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 104 bits (260), Expect = 1e-22
Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 29/288 (10%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ YGA + + T +H AA +G ++V L+L +GA PD + G T L +AA++G
Sbjct: 416 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E++ LLR GA +A + + L A+ G + V LLL++ A + +G+ P+H
Sbjct: 476 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 124 VAADRGHLLALKILIPVTDLAAI-KQSGISPVHCAAAGAHPQCLELLIQ--AGFD---VN 177
++A G + +L+ ++ + G +P+H AA +LL+Q A D N
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGN 234
+ + HY D++K AL LLL GA P+ N L IA +
Sbjct: 596 GLTPLHVAAHY-DNQKVAL-------------LLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 235 YELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYG 280
++ S LL +GA N + V PLH S +T M+ +LL+ G
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT----DMVTLLLDKG 685
Score = 100 bits (249), Expect = 2e-21
Identities = 81/287 (28%), Positives = 128/287 (44%), Gaps = 50/287 (17%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ GA++N + N T L+ AA+ D+VK +L +GA+ + GFTPLA+A Q G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 64 HTEIMEMLLRKGAN-----------AHGQASDSSSILLE--------------------- 91
H + + +LL A + S+++LL+
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234
Query: 92 -----AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLAA 145
AA GN + LLL GA + +G P+HVA+ RG+ +K+L+ + A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 146 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 205
+ G++P+HCAA H Q +ELL++ G + + S L+ A +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL---------SPLHMAAQGDHV 345
Query: 206 SSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN 249
VK LL A + D + L +A G+Y + LLL AN N
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Score = 100 bits (248), Expect = 3e-21
Identities = 78/255 (30%), Positives = 122/255 (47%), Gaps = 27/255 (10%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ G+ V+ TALH A+ G+ ++VK+++ GA+ + QS GFTPL +AAQ H
Sbjct: 83 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IH 123
++++ LL GAN D + L A G+ AVA+LLE N K LP +H
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALH 197
Query: 124 VAADRGHLLALKILIPVTDLAAIK---------QSGISPVHCAAAGAHPQCLELLIQAGF 174
+AA + + +L+ A ++ +SG +P+H AA + LL+ G
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
Query: 175 DVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALR 231
V+F I + L+ A + + VKLLL G +D + L A R
Sbjct: 258 AVDFTARNGI---------TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 232 MGNYELISLLLRHGA 246
G+ +++ LLL GA
Sbjct: 309 SGHDQVVELLLERGA 323
Score = 100 bits (248), Expect = 3e-21
Identities = 78/256 (30%), Positives = 119/256 (46%), Gaps = 19/256 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A++L+ GA +L T LH AAK G D+ KL+L A D G TPL +AA
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ ++ +LL KGA+ H A + + L AA + LL YGA+ NI G
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+A+ GH + +L+ ++ +SG++ +H AA ++L + G D
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD---- 720
Query: 180 LDQRINKHYDDHRK---SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMG 233
D H K + L A ++ V LL GA N N L A + G
Sbjct: 721 --------QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 234 NYELISLLLRHGANVN 249
+ +I++LL+HGA N
Sbjct: 773 HTHIINVLLQHGAKPN 788
Score = 96.3 bits (238), Expect = 5e-20
Identities = 71/255 (27%), Positives = 126/255 (49%), Gaps = 9/255 (3%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIM 68
G D+N N ALH AAK G +V+ +L G+ D + G T L +A+ +G E++
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 69 EMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADR 128
++L+++GAN + Q+ + + L AA + D V LLE GA+ + G P+ VA +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173
Query: 129 GHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHY 188
GH A+ IL+ ++ + +H AA + LL+Q + + +N+
Sbjct: 174 GHNQAVAILLENDTKGKVR---LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR-T 229
Query: 189 DDHRKSALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHG 245
+ + L+ A +++ LLL+ GA + ++ + L +A + GN ++ LLL G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 246 ANVNYFCR--VNPLH 258
++ R + PLH
Sbjct: 290 GQIDAKTRDGLTPLH 304
Score = 81.3 bits (199), Expect = 2e-15
Identities = 70/260 (26%), Positives = 121/260 (46%), Gaps = 13/260 (5%)
Query: 26 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85
AA+ G D V L G + + G L LAA+ GH +++ LL +G++
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 86 SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLA 144
++ L A+ G + V +L++ GA+ N +G P+++AA H+ +K L+ + +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 145 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ-RINKHYDDHRKSALYFAVS-N 202
+ G +P+ A H Q + +L++ L I DD + +AL N
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 217
Query: 203 SDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 260
+D+ S K++++ P L IA GN + +LLL GA V++ R + PLH
Sbjct: 218 ADVQS-KMMVNRTTESGFTP---LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 261 SALQYTLKDEVMLRMLLNYG 280
S T M+++LL+ G
Sbjct: 274 SKRGNT----NMVKLLLDRG 289
Score = 75.9 bits (185), Expect = 7e-14
Identities = 41/155 (26%), Positives = 84/155 (54%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M LL++ GA++++ + T+LH AA+ + ++ ++ GA D + G+TPL +A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ +++ LL++GAN + + + + L +AA G+ + +LL++GA N +G+
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVH 155
+ +A G++ + L VT+ + I+ H
Sbjct: 797 ALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH 831
Score = 61.6 bits (148), Expect = 1e-09
Identities = 44/166 (26%), Positives = 81/166 (48%), Gaps = 13/166 (7%)
Query: 83 SDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVT 141
SDS++ L AA GN D V L+ G D N +G +H+AA GH+ L ++L +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 142 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 201
+ + + G + +H A+ + +++L++ G ++N + + LY A
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ---------SQNGFTPLYMAAQ 139
Query: 202 NSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRH 244
+ + VK LL GA +D L +AL+ G+ + +++LL +
Sbjct: 140 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 116 bits (290), Expect = 4e-26
Identities = 89/280 (31%), Positives = 140/280 (50%), Gaps = 15/280 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N GA V+ N T LH A+K G +MVKL+L G D ++ G TPL AA
Sbjct: 248 VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+SGH +++E+LL +GA + + S L AA G + + V LL++ A +
Sbjct: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
+HVAA GH K+L+ + A +G +P+H A + +ELL++ G + +
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMGNYE 236
+ + + ++ A L+ V LLL GA P+ + L +A R G E
Sbjct: 428 TESGL---------TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 237 LISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLR 274
++ LLR+GA V+ R PLH S L T +++L+
Sbjct: 479 VVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 104 bits (260), Expect = 1e-22
Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 29/288 (10%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ YGA + + T +H AA +G ++V L+L +GA PD + G T L +AA++G
Sbjct: 416 LLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG 475
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E++ LLR GA +A + + L A+ G + V LLL++ A + +G+ P+H
Sbjct: 476 QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Query: 124 VAADRGHLLALKILIPVTDLAAI-KQSGISPVHCAAAGAHPQCLELLIQ--AGFD---VN 177
++A G + +L+ ++ + G +P+H AA +LL+Q A D N
Sbjct: 536 ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN 595
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGN 234
+ + HY D++K AL LLL GA P+ N L IA +
Sbjct: 596 GLTPLHVAAHY-DNQKVAL-------------LLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 235 YELISLLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYG 280
++ S LL +GA N + V PLH S +T M+ +LL+ G
Sbjct: 642 MQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT----DMVTLLLDKG 685
Score = 100 bits (249), Expect = 2e-21
Identities = 81/287 (28%), Positives = 128/287 (44%), Gaps = 50/287 (17%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ GA++N + N T L+ AA+ D+VK +L +GA+ + GFTPLA+A Q G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 64 HTEIMEMLLRKGAN-----------AHGQASDSSSILLE--------------------- 91
H + + +LL A + S+++LL+
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234
Query: 92 -----AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLAA 145
AA GN + LLL GA + +G P+HVA+ RG+ +K+L+ + A
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 146 IKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDL 205
+ G++P+HCAA H Q +ELL++ G + + S L+ A +
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL---------SPLHMAAQGDHV 345
Query: 206 SSVKLLLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN 249
VK LL A + D + L +A G+Y + LLL AN N
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Score = 100 bits (248), Expect = 3e-21
Identities = 78/255 (30%), Positives = 122/255 (47%), Gaps = 27/255 (10%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ G+ V+ TALH A+ G+ ++VK+++ GA+ + QS GFTPL +AAQ H
Sbjct: 83 LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IH 123
++++ LL GAN D + L A G+ AVA+LLE N K LP +H
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALH 197
Query: 124 VAADRGHLLALKILIPVTDLAAIK---------QSGISPVHCAAAGAHPQCLELLIQAGF 174
+AA + + +L+ A ++ +SG +P+H AA + LL+ G
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
Query: 175 DVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALR 231
V+F I + L+ A + + VKLLL G +D + L A R
Sbjct: 258 AVDFTARNGI---------TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308
Query: 232 MGNYELISLLLRHGA 246
G+ +++ LLL GA
Sbjct: 309 SGHDQVVELLLERGA 323
Score = 100 bits (248), Expect = 3e-21
Identities = 78/256 (30%), Positives = 119/256 (46%), Gaps = 19/256 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A++L+ GA +L T LH AAK G D+ KL+L A D G TPL +AA
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ ++ +LL KGA+ H A + + L AA + LL YGA+ NI G
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+A+ GH + +L+ ++ +SG++ +H AA ++L + G D
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD---- 720
Query: 180 LDQRINKHYDDHRK---SALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMG 233
D H K + L A ++ V LL GA N N L A + G
Sbjct: 721 --------QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 234 NYELISLLLRHGANVN 249
+ +I++LL+HGA N
Sbjct: 773 HTHIINVLLQHGAKPN 788
Score = 96.3 bits (238), Expect = 5e-20
Identities = 71/255 (27%), Positives = 126/255 (49%), Gaps = 9/255 (3%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIM 68
G D+N N ALH AAK G +V+ +L G+ D + G T L +A+ +G E++
Sbjct: 54 GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113
Query: 69 EMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADR 128
++L+++GAN + Q+ + + L AA + D V LLE GA+ + G P+ VA +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173
Query: 129 GHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHY 188
GH A+ IL+ ++ + +H AA + LL+Q + + +N+
Sbjct: 174 GHNQAVAILLENDTKGKVR---LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR-T 229
Query: 189 DDHRKSALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHG 245
+ + L+ A +++ LLL+ GA + ++ + L +A + GN ++ LLL G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 246 ANVNYFCR--VNPLH 258
++ R + PLH
Sbjct: 290 GQIDAKTRDGLTPLH 304
Score = 81.3 bits (199), Expect = 2e-15
Identities = 70/260 (26%), Positives = 121/260 (46%), Gaps = 13/260 (5%)
Query: 26 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85
AA+ G D V L G + + G L LAA+ GH +++ LL +G++
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 86 SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLA 144
++ L A+ G + V +L++ GA+ N +G P+++AA H+ +K L+ + +
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 145 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ-RINKHYDDHRKSALYFAVS-N 202
+ G +P+ A H Q + +L++ L I DD + +AL N
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 217
Query: 203 SDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHFP 260
+D+ S K++++ P L IA GN + +LLL GA V++ R + PLH
Sbjct: 218 ADVQS-KMMVNRTTESGFTP---LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 261 SALQYTLKDEVMLRMLLNYG 280
S T M+++LL+ G
Sbjct: 274 SKRGNT----NMVKLLLDRG 289
Score = 75.9 bits (185), Expect = 7e-14
Identities = 41/155 (26%), Positives = 84/155 (54%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M LL++ GA++++ + T+LH AA+ + ++ ++ GA D + G+TPL +A
Sbjct: 677 MVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ +++ LL++GAN + + + + L +AA G+ + +LL++GA N +G+
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVH 155
+ +A G++ + L VT+ + I+ H
Sbjct: 797 ALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKH 831
Score = 61.6 bits (148), Expect = 1e-09
Identities = 44/166 (26%), Positives = 81/166 (48%), Gaps = 13/166 (7%)
Query: 83 SDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVT 141
SDS++ L AA GN D V L+ G D N +G +H+AA GH+ L ++L +
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 142 DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVS 201
+ + + G + +H A+ + +++L++ G ++N + + LY A
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ---------SQNGFTPLYMAAQ 139
Query: 202 NSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRH 244
+ + VK LL GA +D L +AL+ G+ + +++LL +
Sbjct: 140 ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 108 bits (271), Expect = 7e-24
Identities = 81/269 (30%), Positives = 130/269 (48%), Gaps = 15/269 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL+N A V+ N+ T LH A+K G +MVKL+L GA D ++ G TPL A
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+SGH +++EMLL + A + + S L A G + + V LLL++ + N
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 369
Query: 121 PIHVAADRGHLLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
+HVAA GH K+L+ + A +G +P+H A + +ELL++ G + +
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMGNYE 236
+ + + ++ A ++ V L+ GA PN V L +A R G E
Sbjct: 430 TESGL---------TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 237 LISLLLRHGANVNYFCR--VNPLHFPSAL 263
++ L++ GA V + PLH + L
Sbjct: 481 VVRYLVQDGAQVEAKAKDDQTPLHISARL 509
Score = 105 bits (262), Expect = 8e-23
Identities = 76/253 (30%), Positives = 123/253 (48%), Gaps = 13/253 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+AA L+++GA +++ T LH AAK G+ ++ L+L A PD G TPL +AA
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ ++ +LL +GA+ H A + + L AA D LLEYGADAN G
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIA 666
Query: 121 PIHVAADRGHLLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
+H+AA GH+ + +L+ ++ +SG++P+H AA E+L+ G V
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV--- 723
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMGNYE 236
D + Y + L+ ++ V LL A N N L A + G+
Sbjct: 724 -DAQTKMGY-----TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTH 777
Query: 237 LISLLLRHGANVN 249
+I++LL++ A+ N
Sbjct: 778 IINVLLQNNASPN 790
Score = 102 bits (253), Expect = 9e-22
Identities = 77/285 (27%), Positives = 131/285 (45%), Gaps = 30/285 (10%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ +GA + + T +H AA +G ++V ++ GA P+ + G T L +AA+SG
Sbjct: 418 LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG 477
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E++ L++ GA +A D + L +A G D V LL+ GA N SG+ P+H
Sbjct: 478 QAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 124 VAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF---- 178
++A GH +A +L L+ + G +P+H AA + LL+Q +
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS 597
Query: 179 -MLDQRINKHYDDHR-------------------KSALYFAVSNSDLSSVKLLLSAGALP 218
+ + HYD+ + + L+ A + + LL GA
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 219 N---QDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLH 258
N + + + +A + G+ +++SLLL ANVN + + PLH
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702
Score = 96.3 bits (238), Expect = 5e-20
Identities = 78/261 (29%), Positives = 128/261 (49%), Gaps = 21/261 (8%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ A+V+ TALH A+ G+ ++VK+++ +GA+ + QS GFTPL +AAQ H
Sbjct: 93 LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP-IH 123
E+++ LL GA+ D + L A G+ V+LLLE N K LP +H
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALH 207
Query: 124 VAADRGHLLALKILIPVTDLAAIK-QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
+AA + A +L+ + A ++ +SG +P+H AA + LL+ V+F
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELIS 239
I + L+ A + + VKLLL GA +D + L R G+ +++
Sbjct: 268 DI---------TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
Query: 240 LLLRHGANVNYFCR--VNPLH 258
+LL A + + ++PLH
Sbjct: 319 MLLDRAAPILSKTKNGLSPLH 339
Score = 94.0 bits (232), Expect = 2e-19
Identities = 77/280 (27%), Positives = 129/280 (46%), Gaps = 44/280 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ GA+VN + N T L+ AA+ ++VK +L +GA + GFTPLA+A Q G
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 64 HTEIMEMLLRKGAN-----------AHGQASDSSSILLE------------------AAS 94
H +++ +LL A + ++++LL+ AA
Sbjct: 185 HDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244
Query: 95 GGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLAAIKQSGISP 153
GN + LLL A + + P+HVA+ RG+ +K+L+ + A + G++P
Sbjct: 245 YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Query: 154 VHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLS 213
+HC A H Q +E+L+ + ++K + S L+ A L+ V+LLL
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPI-------LSK--TKNGLSPLHMATQGDHLNCVQLLLQ 355
Query: 214 AGALPNQDPVN----CLQIALRMGNYELISLLLRHGANVN 249
+P D N L +A G+Y++ +LL AN N
Sbjct: 356 HN-VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/261 (26%), Positives = 123/261 (47%), Gaps = 23/261 (8%)
Query: 6 INYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT 65
I G D+N+ N ALH A+K G ++V +L A+ D + G T L +A+ +G
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120
Query: 66 EIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVA 125
E++++L+ GAN + Q+ + + L AA + + V LL+ GA ++ G P+ VA
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
Query: 126 ADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRIN 185
+GH + +L+ ++ + +H AA + LL+Q +
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVR---LPALHIAARKDDTKAAALLLQN------------D 225
Query: 186 KHYDDHRKSA---LYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELIS 239
+ D KS L+ A +++ LLL+ A + ++ + L +A + GN ++
Sbjct: 226 NNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVK 285
Query: 240 LLLRHGANVNYFCR--VNPLH 258
LLL GA ++ R + PLH
Sbjct: 286 LLLDRGAKIDAKTRDGLTPLH 306
Score = 78.2 bits (191), Expect = 1e-14
Identities = 62/242 (25%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 26 AAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDS 85
AA+ G + + +G + + G L LA++ GH E++ LL++ AN
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 86 SSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP-VTDLA 144
++ L A+ G + V +L+ GA+ N +G P+++AA HL +K L+ +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 145 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD 204
+ G +P+ A H Q + LL++ N R AL+ A D
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLE-------------NDTKGKVRLPALHIAARKDD 214
Query: 205 LSSVKLLL---SAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCR--VNPLHF 259
+ LLL + + ++ L IA GN + +LLL A V++ R + PLH
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 274
Query: 260 PS 261
S
Sbjct: 275 AS 276
Score = 77.8 bits (190), Expect = 2e-14
Identities = 65/256 (25%), Positives = 121/256 (47%), Gaps = 21/256 (8%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
AALL+ + ++ + T LH AA G ++ L+L A D + TPL +A++
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
G+ ++++LL +GA + D + L A G+ V +LL+ A +G P
Sbjct: 278 RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSP 337
Query: 122 IHVAADRGHLLALKIL----IPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
+H+A HL +++L +PV D + ++ +H AA H + ++L
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPVDD---VTNDYLTALHVAAHCGHYKVAKVL-------- 386
Query: 178 FMLDQRINKHYDD-HRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMG 233
LD++ N + + + L+ A + + ++LLL GA + + + +A MG
Sbjct: 387 --LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
Query: 234 NYELISLLLRHGANVN 249
+ ++S L+ HGA+ N
Sbjct: 445 HVNIVSQLMHHGASPN 460
Score = 68.6 bits (166), Expect = 1e-11
Identities = 41/142 (28%), Positives = 76/142 (53%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M +LL+ A+VNL + T LH AA+ R ++ ++++ GAH D Q+ G+TPL +
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC 738
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
G+ +I+ LL+ A + + + + L +AA G+ + +LL+ A N +G+
Sbjct: 739 HYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798
Query: 121 PIHVAADRGHLLALKILIPVTD 142
+ +A G++ + L VT+
Sbjct: 799 ALGIARRLGYISVVDTLKIVTE 820
Score = 62.4 bits (150), Expect = 8e-10
Identities = 46/176 (26%), Positives = 86/176 (48%), Gaps = 13/176 (7%)
Query: 73 RKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL- 131
RK + + SD+++ L AA G+ + ++ G D NI +G +H+A+ GH+
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 132 LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDH 191
+ ++L ++ A + G + +H A+ + +++L+ G +VN +
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ---------SQN 139
Query: 192 RKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRH 244
+ LY A + L VK LL GA L +D L +AL+ G+ +++SLLL +
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 105 bits (263), Expect = 6e-23
Identities = 70/216 (32%), Positives = 114/216 (52%), Gaps = 11/216 (5%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ GAD+NL+ + TAL AA+ G D+V+ + GA + ++ G T L A+Q GH
Sbjct: 65 LVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGH 124
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHV 124
+++E LL+ GAN H Q D ++ L AA GG D + LLL GA N P+ G P+ +
Sbjct: 125 MQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWI 184
Query: 125 AADRGHLLALKI-LIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
A+ GH +++ L+ D A + G + + AA + ++ L++ + +
Sbjct: 185 ASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL---- 240
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPN 219
+ SAL+ AV + ++ +V LLL AGA P+
Sbjct: 241 ------KNGTSALHAAVLSGNIKTVALLLEAGADPS 270
Score = 72.4 bits (176), Expect = 7e-13
Identities = 60/203 (29%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 54 TPLA----LAAQSGHTEIMEMLLRKG-ANAHGQASDSSSILLEAASGGNPDAVALLLEYG 108
TPLA AA+ G+ ++++LL G + + S +++L+ AA G+ D V L+ G
Sbjct: 10 TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
Query: 109 ADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIK-QSGISPVHCAAAGAHPQCLE 167
AD N+ + SG + AA +GH ++ L + + G + + A+ H Q +E
Sbjct: 70 ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
Query: 168 LLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGAL---PNQDPVN 224
L++ G +++ L YD +AL+ A L ++LLL++GA P QD
Sbjct: 130 TLLKHGANIHDQL-------YDG--ATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
Query: 225 CLQIALRMGNYELISLLLRHGAN 247
L IA +MG+ E++ ++L GA+
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGAD 203
Score = 67.0 bits (162), Expect = 3e-11
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 32/163 (19%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ +GA+++ + + TAL AA+ G D+++L+L SGA + G PL +A+Q GH
Sbjct: 131 LLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGH 190
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAAS------------------------------ 94
+E++ ++L +GA+ +D ++ LL+AA+
Sbjct: 191 SEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAA 250
Query: 95 --GGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
GN VALLLE GAD ++ + LP + + L L+
Sbjct: 251 VLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLR 293
Score = 47.4 bits (111), Expect = 3e-05
Identities = 36/130 (27%), Positives = 58/130 (44%), Gaps = 14/130 (10%)
Query: 125 AADRGHLLALKILIPV--TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
AA RG+L LK+L+ D+ G + + AA H C+ L+ G D+N +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELIS 239
+AL+FA V+ L GA +D L A + G+ +++
Sbjct: 79 GT---------TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
Query: 240 LLLRHGANVN 249
LL+HGAN++
Sbjct: 130 TLLKHGANIH 139
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 104 bits (260), Expect = 1e-22
Identities = 92/327 (28%), Positives = 145/327 (44%), Gaps = 66/327 (20%)
Query: 9 GADVNLRCANE--RTALHEAAKLGREDMVKLML----------VSGAHPDPQSTYGFTPL 56
G VN R N R ALH AA G E V+L+L GA + + +G L
Sbjct: 36 GRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNAL 95
Query: 57 ALAAQSGHTEIMEMLLRKGANAHGQASDSSSIL------------------LE------- 91
L+A GH I+++L+ GA H ++ D ++L LE
Sbjct: 96 LLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV 155
Query: 92 ----------AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPV- 140
AA G DA+ L+ G D N+ G+ +H+AA RGH+ L+ L+ +
Sbjct: 156 DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215
Query: 141 TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAV 200
DL G++ +H AA G+HP C++LL++AG VN + + + S L++A
Sbjct: 216 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNL---------SCLHYAA 266
Query: 201 SNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNYF--CRVN 255
+ ++L+ AG N + L +A+R L+ LL+ ++VN +
Sbjct: 267 LSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQT 326
Query: 256 PLHFPSALQYTLKDEVMLRMLLNYGYD 282
PLH A ++ +D + MLL G D
Sbjct: 327 PLHL--AAEHAWQD--IADMLLIAGVD 349
Score = 86.7 bits (213), Expect = 4e-17
Identities = 64/228 (28%), Positives = 107/228 (46%), Gaps = 13/228 (5%)
Query: 20 RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAH 79
RTA H AA+ G+ D + ++ SG + + G T L LAA GH +++ L+ G +
Sbjct: 160 RTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLE 219
Query: 80 GQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIP 139
Q ++ + L AA G +PD V LLL G+ N +H AA G ++LI
Sbjct: 220 EQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIH 279
Query: 140 VTDLA-AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYF 198
A + G SP+H A P + LLI + DVN + D+ +++ L+
Sbjct: 280 AGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAV---------DNRQQTPLHL 330
Query: 199 AVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLR 243
A ++ +LL AG L ++ L +A+R + L+ ++++
Sbjct: 331 AAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
Score = 86.3 bits (212), Expect = 5e-17
Identities = 60/211 (28%), Positives = 103/211 (48%), Gaps = 10/211 (4%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ G D N++ TALH AA G +++ ++ G + Q+ G T L AA H
Sbjct: 178 LVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSH 237
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHV 124
+ +++LLR G+ + + S L AA G+ D +L+ G AN+ + G P+H+
Sbjct: 238 PDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHL 297
Query: 125 AADRGHLLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
A +++LI +D+ A+ +P+H AA A ++L+ AG D+N
Sbjct: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLR---- 353
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSA 214
D K+AL AV ++ +S V +++ A
Sbjct: 354 -----DKQGKTALAVAVRSNHVSLVDMIIKA 379
Score = 49.7 bits (117), Expect = 5e-06
Identities = 33/135 (24%), Positives = 61/135 (45%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ G+ VN + LH AA G ED+ ++++ +G + G +PL LA +
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
++ +L+ ++ + + + L AA D +LL G D N+ G +
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362
Query: 124 VAADRGHLLALKILI 138
VA H+ + ++I
Sbjct: 363 VAVRSNHVSLVDMII 377
Score = 47.4 bits (111), Expect = 3e-05
Identities = 23/73 (31%), Positives = 44/73 (60%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+ LLIN +DVN ++T LH AA+ +D+ ++L++G + + G T LA+A
Sbjct: 306 LVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAV 365
Query: 61 QSGHTEIMEMLLR 73
+S H +++M+++
Sbjct: 366 RSNHVSLVDMIIK 378
Score = 32.3 bits (72), Expect = 0.83
Identities = 24/106 (22%), Positives = 49/106 (46%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
++ +LI+ G N+ + LH A + +V+L++ S + + TPL LAA
Sbjct: 273 VSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAA 332
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE 106
+ +I +MLL G + + + + L A + V ++++
Sbjct: 333 EHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 102 bits (254), Expect = 7e-22
Identities = 93/293 (31%), Positives = 139/293 (47%), Gaps = 26/293 (8%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
A L+ ++VN+ RTALH AA G +MVKL+L GA+ + + AA
Sbjct: 123 AEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
GH E++++L+ GA + S + L AAS G V LL+ G D N P G+ P
Sbjct: 183 MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
Query: 122 IHVAADRGHLLALKILIPVTDLAAI----KQSGISPVHCAAAGAH-PQCLELLIQAGFDV 176
+HVA G + + LI D AI + G +P+H AAA H CLELL+ G DV
Sbjct: 243 LHVACYNGQDVVVNELI---DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN---CLQIALRMG 233
N K D K+ L+ + S + ++ +GA+ + + N L IA R G
Sbjct: 300 NM-------KSKDG--KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 234 NYELISLLLRHGANV--NYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
+ LI+ L+ GA+ + PLH + ++ R LL+ G+D +
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFS----DCCRKLLSSGFDID 399
Score = 91.3 bits (225), Expect = 2e-18
Identities = 69/216 (31%), Positives = 104/216 (48%), Gaps = 9/216 (4%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ GADVN++ + +T LH A GR + ++ SGA D + G TPL +AA+ G
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H ++ L+ GA+ + L AA G D LL G D + P + G +H
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 124 VAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
AA G+L L +L+ D + G SP+H AAA + QCL L+ +G VN + ++
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP 218
+ Y A S++D ++ LL A P
Sbjct: 471 GCTPLH--------YAATSDTDGKCLEYLLRNDANP 498
Score = 90.9 bits (224), Expect = 2e-18
Identities = 78/261 (29%), Positives = 121/261 (46%), Gaps = 26/261 (9%)
Query: 4 LLINYGADVNLR-CANERTALHEAAKLGREDMVKLMLVSGAHP----DPQSTYGFTPLAL 58
+LIN GA + ++ +RT +H AA G + ++L L+ A P D Q G TPL L
Sbjct: 601 VLINQGASILVKDYILKRTPIHAAATNGHSECLRL-LIGNAEPQNAVDIQDGNGQTPLML 659
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
+ +GHT+ + LL KGAN + + L A G+ + V LL++GA + + G
Sbjct: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719
Query: 119 HLPIHVAADRGHLLALKILIPV-----TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAG 173
PIH++A GH+ L L+ + A G + +H A H C+ELL
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL---- 775
Query: 174 FDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLL---LSAGALPNQDPV--NCLQI 228
L+Q + + + + S L+ AV N + + ++L L A + D L
Sbjct: 776 ------LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829
Query: 229 ALRMGNYELISLLLRHGANVN 249
A + E + LLL H A VN
Sbjct: 830 AAFTDHVECLQLLLSHNAQVN 850
Score = 82.4 bits (202), Expect = 7e-16
Identities = 75/278 (26%), Positives = 129/278 (46%), Gaps = 18/278 (6%)
Query: 11 DVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEM 70
DVN + +RT LH AA LG ++++L+++SGA + + + TPL A S E +++
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
Query: 71 LLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGH 130
LL+ A+ + + + + L AA+ L+ ++ N+ +G +H AA GH
Sbjct: 93 LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152
Query: 131 LLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYD 189
+K+L+ ++ A + +H AA H + ++LL+ G +V D
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK---------D 203
Query: 190 DHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGA 246
+ L+ A S+ +S VK LL G PN L +A G +++ L+ GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 247 NVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYD 282
VN PLHF +A + + L +L+ G D
Sbjct: 264 IVNQKNEKGFTPLHFAAA---STHGALCLELLVGNGAD 298
Score = 77.8 bits (190), Expect = 2e-14
Identities = 60/235 (25%), Positives = 113/235 (48%), Gaps = 13/235 (5%)
Query: 19 ERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANA 78
++ +L +A G D V+ ++ + Q TPL AA G EI+E+L+ GA
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 79 HGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI 138
+ + S + L A + + +AV +LL++ AD N + P+H+AA + + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 139 P-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALY 197
P ++++ ++G + +H AA H + ++LL+ G ++N +D + A++
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN---------AFDKKDRRAIH 178
Query: 198 FAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
+A + VKLL+S GA ++ L A G ++ LL G ++N
Sbjct: 179 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN 233
Score = 61.2 bits (147), Expect = 2e-09
Identities = 66/261 (25%), Positives = 108/261 (41%), Gaps = 52/261 (19%)
Query: 23 LHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA------ 76
LH AA G +++++ S D +++ G TPL LAA GH E +++L+ +GA
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 77 -------------NAH--------GQASDSSSILLEAASG----------GNPDAVALLL 105
N H G A +++ ++ +G G+ D V LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 106 EYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQS-GISPVHCAAAGAHPQ 164
GA+ + G +H A GH + L+ ++ S G +P+H +AA H
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
Query: 165 CLELLIQ--AGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQD- 221
L L+Q A D N D+H +AL++A N + V+LLL +
Sbjct: 734 VLGALLQSAASMDAN-------PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG 786
Query: 222 ----PVNCLQIALRMGNYELI 238
P++C I G E++
Sbjct: 787 NAFSPLHCAVINDNEGAAEML 807
Score = 59.7 bits (143), Expect = 5e-09
Identities = 48/165 (29%), Positives = 81/165 (49%), Gaps = 6/165 (3%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
VN + RT LH AA + ++L+L A + + G TPL +AA++G T +EML
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 72 LRK-GANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG---HLPIHVAAD 127
+ A Q + ++ L A S G+ + L+LE D N+ + P+HVAA
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAAR 935
Query: 128 RGHLLALKILI-PVTDLAAIKQSGISP-VHCAAAGAHPQCLELLI 170
G + ++ L+ + A+ ++G +P + CA CL L++
Sbjct: 936 NGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/261 (24%), Positives = 104/261 (39%), Gaps = 60/261 (22%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKL----------MLVSGAH--PDPQSTYG 52
L+ A+ +R A+H +A G ++L M SG D +
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 53 FTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADAN 112
+PL LAA GH + +E+L++ S+L D +
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQ-------------SLL--------------------DLD 577
Query: 113 IPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGI--SPVHCAAAGAHPQCLELLI 170
+ +SG P+ +AA +GH+ + +LI +K + +P+H AA H +CL LLI
Sbjct: 578 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Query: 171 QAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN-----C 225
N + Q D + ++ L +V N V LL+ GA N D +
Sbjct: 638 GNAEPQNAVDIQ------DGNGQTPLMLSVLNGHTDCVYSLLNKGA--NVDAKDKWGRTA 689
Query: 226 LQIALRMGNYELISLLLRHGA 246
L G+ E + LL+HGA
Sbjct: 690 LHRGAVTGHEECVDALLQHGA 710
Score = 33.5 bits (75), Expect = 0.37
Identities = 31/111 (27%), Positives = 54/111 (48%), Gaps = 14/111 (12%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLM--------LVSGAHPDPQSTYGFTP 55
L+ + A++ L+ ++ TALH A G E L+ L++ + Q TP
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ-----TP 929
Query: 56 LALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGN-PDAVALLL 105
L +AA++G T +++ LL KGA+ + + L A + D +AL+L
Sbjct: 930 LHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 100 bits (249), Expect = 2e-21
Identities = 81/267 (30%), Positives = 124/267 (46%), Gaps = 34/267 (12%)
Query: 17 ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 76
+N TAL A G E++V+ +L GA + + GFTPL LAA +GH ++E+LL GA
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
Query: 77 NAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
+ Q+ + L A SGG + V LLL GA+ S + P+ +AA G++ +K
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
Query: 136 ILIPV---TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN--------------- 177
IL+ + + GISP+ AA H ++LL+ G D+N
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
Query: 178 ---------FMLDQRIN-KHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---- 223
+LD++ N +H + L A S ++LL GA N PV
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 224 -NCLQIALRMGNYELISLLLRHGANVN 249
L IA G+Y+ LL+ GA+++
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHID 1347
Score = 98.6 bits (244), Expect = 9e-21
Identities = 82/281 (29%), Positives = 123/281 (43%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + + TAL A G D+VK++L SGA + + G TPL A +G
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ L +
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A L
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQG--------ANINAQTEETQETALTLACCGGFLEVA 550
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 551 DFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH 591
Score = 96.7 bits (239), Expect = 4e-20
Identities = 73/253 (28%), Positives = 126/253 (49%), Gaps = 18/253 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL++ GA VN+ + + L AA G ++ L++ GA + + G+TPL AA
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGH 119
+ GH E++ +LL +GAN + Q ++ L A GG + L++ GAD + ++
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCST-- 566
Query: 120 LPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
P+ AA GHL +K L+ ++ A +G + + A H ++L+QAG D+
Sbjct: 567 -PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL-- 623
Query: 179 MLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN----CLQIALRMGN 234
+H + ++ L A + +V+ L+S GA N+ N L +A G+
Sbjct: 624 -------EHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Query: 235 YELISLLLRHGAN 247
++ LLL HGA+
Sbjct: 677 LAVVELLLAHGAD 689
Score = 89.4 bits (220), Expect = 6e-18
Identities = 65/187 (34%), Positives = 102/187 (54%), Gaps = 6/187 (3%)
Query: 4 LLINYGADVNLRCANER--TALHEAAKLGREDMVKLMLVSGAHPDPQ-STYGFTPLALAA 60
+L+N GA++N R ++ + L AA G VKL+L G+ + Q T T L LA
Sbjct: 1201 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1260
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPK--NSG 118
G TE++ +LL + AN +A + L+EAASGG + +LL+ GAD N P +S
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 119 HLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
+ +AAD+GH ++LI + + G +P+ AA G H ++LL+QAG DV+
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1380
Query: 178 FMLDQRI 184
+++I
Sbjct: 1381 AADNRKI 1387
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/286 (26%), Positives = 131/286 (45%), Gaps = 25/286 (8%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYG-FTPLALAAQSG 63
L+ G VN + L A G ++ +++L A+ + + G TPL AA G
Sbjct: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +I+++LL A+ + Q+S ++ L A +GG D V +LLE GA +GH P+
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372
Query: 124 VAADRGHLLALKILIP-----VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
A GH+ ++L+ T K+S ++ A H + + L++AG D
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMVRFLLEAGAD--- 426
Query: 179 MLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNY 235
+H D +AL A + + +LLL +GA +P + L +A G+
Sbjct: 427 ------QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 236 ELISLLLRHGANVNYFCRVNPLHFPSALQYTLK-DEVMLRMLLNYG 280
EL +LL+ GA++ VN + ++ + E M+ +LL G
Sbjct: 481 ELAALLIERGASLE---EVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Score = 81.6 bits (200), Expect = 1e-15
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A LL+ GA +N +NE +AL A G +MV+ +L +GA + ++ T L
Sbjct: 382 VARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA + G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFD- 175
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 176 -------------------VNFMLDQRINKHYDDHR-KSALYFAVSNSDLSSVKLLLSAG 215
V ++L N H +AL +A N +LL AG
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 216 A---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
A ++ L A R G+ + L+ GANVN
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 67.8 bits (164), Expect = 2e-11
Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 1/127 (0%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ GA+V+ A TAL A + G D+ ++L +GA + +S G TPL AA++GH
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 65 TEIMEMLLRKGANAH-GQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
++ L+ KGAN + A++ ++L A +GG+ V LLL +GAD G +
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 702
Query: 124 VAADRGH 130
AA GH
Sbjct: 703 EAAKGGH 709
Score = 65.9 bits (159), Expect = 7e-11
Identities = 43/140 (30%), Positives = 75/140 (53%), Gaps = 2/140 (1%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGA--HPDPQSTYGFTPLAL 58
+ +LL++ A+V R T L EAA G ++ +++L GA + P + T L +
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
AA GH + E+L+ +GA+ + ++ L AA+GG+ D V LL++ GAD + N
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 119 HLPIHVAADRGHLLALKILI 138
P+ A +GH+ ++ L+
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLV 1406
Score = 63.2 bits (152), Expect = 4e-10
Identities = 37/108 (34%), Positives = 60/108 (55%), Gaps = 1/108 (0%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYG-FTPLALA 59
+A +L+ GAD+ RT L +AA+ G V+ ++ GA+ + + T L+LA
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 60 AQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEY 107
GH ++E+LL GA+ + D S++L+EAA GG+ V LL+Y
Sbjct: 672 CAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 52.8 bits (125), Expect = 6e-07
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 2/105 (1%)
Query: 4 LLINYGADVNLRC--ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
+L++ GADVN ++ TAL AA G +L++ GAH D ++ G TPL LAA
Sbjct: 1303 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1362
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE 106
GH +++++L++ GA+ + + L+ A G+ V L++
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 43.5 bits (101), Expect = 4e-04
Identities = 24/71 (33%), Positives = 39/71 (54%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LLI GA +++R T L AA G D+V+L++ +GA D TPL A + G
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397
Query: 64 HTEIMEMLLRK 74
H +++ L+++
Sbjct: 1398 HVKVVRYLVKE 1408
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 100 bits (249), Expect = 2e-21
Identities = 81/267 (30%), Positives = 124/267 (46%), Gaps = 34/267 (12%)
Query: 17 ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 76
+N TAL A G E++V+ +L GA + + GFTPL LAA +GH ++E+LL GA
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 77 NAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
+ Q+ + L A SGG + V LLL GA+ S + P+ +AA G++ +K
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 136 ILIPV---TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN--------------- 177
IL+ + + GISP+ AA H ++LL+ G D+N
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 178 ---------FMLDQRIN-KHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---- 223
+LD++ N +H + L A S ++LL GA N PV
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
Query: 224 -NCLQIALRMGNYELISLLLRHGANVN 249
L IA G+Y+ LL+ GA+++
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAHID 1096
Score = 98.6 bits (244), Expect = 9e-21
Identities = 82/281 (29%), Positives = 123/281 (43%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + + TAL A G D+VK++L SGA + + G TPL A +G
Sbjct: 319 LLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAG 378
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 379 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL 438
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ L +
Sbjct: 439 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND 498
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A L
Sbjct: 499 EGYTPLMEAAREGHEEMVALLLGQG--------ANINAQTEETQETALTLACCGGFLEVA 550
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 551 DFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVH 591
Score = 96.7 bits (239), Expect = 4e-20
Identities = 73/253 (28%), Positives = 126/253 (49%), Gaps = 18/253 (7%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL++ GA VN+ + + L AA G ++ L++ GA + + G+TPL AA
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGH 119
+ GH E++ +LL +GAN + Q ++ L A GG + L++ GAD + ++
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCST-- 566
Query: 120 LPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
P+ AA GHL +K L+ ++ A +G + + A H ++L+QAG D+
Sbjct: 567 -PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADL-- 623
Query: 179 MLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVN----CLQIALRMGN 234
+H + ++ L A + +V+ L+S GA N+ N L +A G+
Sbjct: 624 -------EHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGH 676
Query: 235 YELISLLLRHGAN 247
++ LLL HGA+
Sbjct: 677 LAVVELLLAHGAD 689
Score = 89.4 bits (220), Expect = 6e-18
Identities = 65/187 (34%), Positives = 102/187 (54%), Gaps = 6/187 (3%)
Query: 4 LLINYGADVNLRCANER--TALHEAAKLGREDMVKLMLVSGAHPDPQ-STYGFTPLALAA 60
+L+N GA++N R ++ + L AA G VKL+L G+ + Q T T L LA
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC 1009
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPK--NSG 118
G TE++ +LL + AN +A + L+EAASGG + +LL+ GAD N P +S
Sbjct: 1010 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1069
Query: 119 HLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
+ +AAD+GH ++LI + + G +P+ AA G H ++LL+QAG DV+
Sbjct: 1070 DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD 1129
Query: 178 FMLDQRI 184
+++I
Sbjct: 1130 AADNRKI 1136
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/286 (26%), Positives = 131/286 (45%), Gaps = 25/286 (8%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYG-FTPLALAAQSG 63
L+ G VN + L A G ++ +++L A+ + + G TPL AA G
Sbjct: 253 LLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H +I+++LL A+ + Q+S ++ L A +GG D V +LLE GA +GH P+
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372
Query: 124 VAADRGHLLALKILIP-----VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
A GH+ ++L+ T K+S ++ A H + + L++AG D
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALT---LACYKGHLEMVRFLLEAGAD--- 426
Query: 179 MLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNY 235
+H D +AL A + + +LLL +GA +P + L +A G+
Sbjct: 427 ------QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 236 ELISLLLRHGANVNYFCRVNPLHFPSALQYTLK-DEVMLRMLLNYG 280
EL +LL+ GA++ VN + ++ + E M+ +LL G
Sbjct: 481 ELAALLIERGASLE---EVNDEGYTPLMEAAREGHEEMVALLLGQG 523
Score = 81.6 bits (200), Expect = 1e-15
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A LL+ GA +N +NE +AL A G +MV+ +L +GA + ++ T L
Sbjct: 382 VARLLLENGAGINTH-SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA + G
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFD- 175
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 176 -------------------VNFMLDQRINKHYDDHR-KSALYFAVSNSDLSSVKLLLSAG 215
V ++L N H +AL +A N +LL AG
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAG 620
Query: 216 A---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
A ++ L A R G+ + L+ GANVN
Sbjct: 621 ADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 67.8 bits (164), Expect = 2e-11
Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 1/127 (0%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L+ GA+V+ A TAL A + G D+ ++L +GA + +S G TPL AA++GH
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 65 TEIMEMLLRKGANAH-GQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
++ L+ KGAN + A++ ++L A +GG+ V LLL +GAD G +
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 702
Query: 124 VAADRGH 130
AA GH
Sbjct: 703 EAAKGGH 709
Score = 65.9 bits (159), Expect = 7e-11
Identities = 43/140 (30%), Positives = 75/140 (53%), Gaps = 2/140 (1%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGA--HPDPQSTYGFTPLAL 58
+ +LL++ A+V R T L EAA G ++ +++L GA + P + T L +
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
AA GH + E+L+ +GA+ + ++ L AA+GG+ D V LL++ GAD + N
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 119 HLPIHVAADRGHLLALKILI 138
P+ A +GH+ ++ L+
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155
Score = 63.2 bits (152), Expect = 4e-10
Identities = 37/108 (34%), Positives = 60/108 (55%), Gaps = 1/108 (0%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYG-FTPLALA 59
+A +L+ GAD+ RT L +AA+ G V+ ++ GA+ + + T L+LA
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 60 AQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEY 107
GH ++E+LL GA+ + D S++L+EAA GG+ V LL+Y
Sbjct: 672 CAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 52.8 bits (125), Expect = 6e-07
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 2/105 (1%)
Query: 4 LLINYGADVNLRC--ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
+L++ GADVN ++ TAL AA G +L++ GAH D ++ G TPL LAA
Sbjct: 1052 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAAN 1111
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE 106
GH +++++L++ GA+ + + L+ A G+ V L++
Sbjct: 1112 GGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 43.5 bits (101), Expect = 4e-04
Identities = 24/71 (33%), Positives = 39/71 (54%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LLI GA +++R T L AA G D+V+L++ +GA D TPL A + G
Sbjct: 1087 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1146
Query: 64 HTEIMEMLLRK 74
H +++ L+++
Sbjct: 1147 HVKVVRYLVKE 1157
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 99.0 bits (245), Expect = 7e-21
Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 28/269 (10%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LL++ AD NL A +T LH AA G +VKL+ GA D Q TPL LA
Sbjct: 476 VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+ G ++ LL+ GA L AA+ G +LL YGA +P + G
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN-- 177
P+H+AA +GHL + +L ++ A+ +P+H AA + L+Q G D N
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
Query: 178 --------FMLDQR---------INKHYDDHRKSAL-----YFAVSNSDLSSVKLLLSAG 215
+ QR + H + H ++ + + A + + +K+L+ AG
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715
Query: 216 A-LPNQDPVNC--LQIALRMGNYELISLL 241
A L QD V+C LQ+ALR ++S L
Sbjct: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 94.4 bits (233), Expect = 2e-19
Identities = 68/235 (28%), Positives = 115/235 (48%), Gaps = 13/235 (5%)
Query: 18 NERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGAN 77
N+ T LH G + V+L+L D Q+ G+TPL +AAQ ++ +LL GA+
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 78 AHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKIL 137
A+ D + L AA G+ LLL++GA + + G P+H+AA ++L
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 138 IP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSAL 196
+ D + G +P+H AA H ++LL G +++ QR + ++ L
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD--AQQR-------NLRTPL 531
Query: 197 YFAVSNSDLSSVKLLLSAGALP---NQDPVNCLQIALRMGNYELISLLLRHGANV 248
+ AV + +++ LL +GA+P +Q L A G Y + +LLR+GA++
Sbjct: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Score = 90.1 bits (222), Expect = 3e-18
Identities = 78/258 (30%), Positives = 125/258 (48%), Gaps = 23/258 (8%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+ ALL+ +GAD N + LH AA+ G + +L+L GA D Q G+TPL LAA
Sbjct: 410 LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA 469
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
Q+ + +L+ + A+ + ++ + L AA G+ V LL GA+ + + +
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529
Query: 121 PIHVAADRGHLLALKILI---PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
P+H+A +RG + A++ L+ V D A+ QSG P+H AAA ++L++ G +
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPD--ALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587
Query: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSA----GAL--PNQDPVNCLQIALR 231
Q + L+ A L + LL + GAL N P L +A R
Sbjct: 588 LPTHQ---------GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP---LHLAAR 635
Query: 232 MGNYELISLLLRHGANVN 249
G ++S LL+ GA+ N
Sbjct: 636 HGEEAVVSALLQCGADPN 653
Score = 85.1 bits (209), Expect = 1e-16
Identities = 81/285 (28%), Positives = 127/285 (44%), Gaps = 19/285 (6%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + DV+ + A+ T L AA+ + D+ L+L GA + G+ PL AAQ+G
Sbjct: 380 LLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNG 439
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
+LL GA Q + + L AA + LL+ AD N+ + G P+H
Sbjct: 440 DDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLH 499
Query: 124 VAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
VAA GH+ +K+L +L A +++ +P+H A + ++ L+++G
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG--------- 550
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELIS 239
+ D L+ A + K+LL GA LP L +A G+ E+I
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 240 LLLRHGANVNYFCRVN--PLHFPSALQYTLKDEVMLRMLLNYGYD 282
LL AN+ VN PLH L +E ++ LL G D
Sbjct: 611 LLAESHANMGALGAVNWTPLH----LAARHGEEAVVSALLQCGAD 651
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 98.6 bits (244), Expect = 9e-21
Identities = 79/267 (29%), Positives = 123/267 (46%), Gaps = 34/267 (12%)
Query: 17 ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 76
+N TAL A G E++V +++ A + + GFTPL LAA +GH ++E+LL KG
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 77 NAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
+ Q+ + L A SGG + V LLL GA+ S + P+ +AA G++ +K
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 136 ILIPV---TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN--------------- 177
IL+ + + GISP+ AA H ++LL+ G D+N
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
Query: 178 ---------FMLDQRIN-KHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---- 223
+LD++ N +H + L A S ++LL GA N PV
Sbjct: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 224 -NCLQIALRMGNYELISLLLRHGANVN 249
L IA G+Y+ LL+ GA+++
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.3 bits (238), Expect = 5e-20
Identities = 82/281 (29%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + A TAL A G D+VK++L GA+ + + G TPL AA +G
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ +L +
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQG--------ANINAQTEETQETALTLACCGGFSEVA 521
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 522 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/237 (29%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T L A+ G D+VKL+L+ A + QS G T L A G +I+++LL +GAN
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS-GHLPIHVAADRGHLLALKILIP 139
+ + L+EAAS G+ + +LL++GA N N + +A +GHL ++ L+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL- 392
Query: 140 VTDLAAIKQSGISPVHCAAAGA----HPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSA 195
+ A ++ +H A A H + LL+ +G VN D +S
Sbjct: 393 --EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS---------FESP 441
Query: 196 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L A + LL+ GA N + L A R G+ E+++LLL GAN+N
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 87.4 bits (215), Expect = 2e-17
Identities = 95/369 (25%), Positives = 157/369 (42%), Gaps = 44/369 (11%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A +L+++GA +N +NE +AL A G DMV+ +L +GA + ++ T L
Sbjct: 353 VARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA+ + G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFD- 175
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 176 -------------------VNFMLDQRINKHYDDHR-KSALYFAVSNSDLSSVKLLLSAG 215
V ++L N H +AL +A N +LL AG
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 216 A---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVM 272
A ++ L A R G+ + L+ GANVN N H +L +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR-ATANNDHTVVSLACAGGHLAV 650
Query: 273 LRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVR 332
+ +LL +G D P++ ++ ++ +I+ K +S+L V+
Sbjct: 651 VELLLAHGAD--------------PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Query: 333 VMLDYVDQV 341
V V Q+
Sbjct: 697 VPTTDVSQL 705
Score = 86.7 bits (213), Expect = 4e-17
Identities = 65/196 (33%), Positives = 103/196 (52%), Gaps = 6/196 (3%)
Query: 4 LLINYGADVNLRCANER--TALHEAAKLGREDMVKLMLVSGAHPDPQ-STYGFTPLALAA 60
+L+N GA++N R ++ + L AA G VKL+L G+ + Q T T L LA
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPK--NSG 118
G E++ +LL + AN +A + L+EAASGG + +LL+ GAD N P +S
Sbjct: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 119 HLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
+ +AAD+GH ++LI + + G +P+ A+ G H ++LL+QAG DV+
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Query: 178 FMLDQRINKHYDDHRK 193
+++I RK
Sbjct: 1353 AADNRKITPLMSAFRK 1368
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/140 (30%), Positives = 75/140 (53%), Gaps = 2/140 (1%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGA--HPDPQSTYGFTPLAL 58
+ +LL++ A+V R T L EAA G ++ +++L GA + P + T L +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
AA GH + E+L+ +GA+ + ++ L A++GG+ D V LL++ GAD + N
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 119 HLPIHVAADRGHLLALKILI 138
P+ A +GH+ ++ L+
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLV 1378
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/292 (26%), Positives = 118/292 (40%), Gaps = 26/292 (8%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSG-AHPDPQSTYGFTPLALAAQSGHTEI 67
GAD LR + T A L + KL G A DP+ T A
Sbjct: 132 GAD--LRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
Query: 68 MEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAAD 127
+ + K N+H + L EA S G+ +AV LL+ G N G + +A
Sbjct: 190 LTRM--KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
Query: 128 RGHLLALKILIPVTDLAAIKQSG----ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
G+ ++L+ + A ++ G I+P+ A++G + ++LL+ DVN
Sbjct: 248 AGYYELAQVLLAMH--ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN------ 299
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGAL---PNQDPVNCLQIALRMGNYELISL 240
+AL +A + + VK+LL+ GA N++ L A G+ E+ +
Sbjct: 300 ---SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 241 LLRHGANVNYFCRVNPLHFPSALQYTLKDEV-MLRMLLNYGYDTERCFDCPH 291
LL HGA +N N + K + M+R LL G D E D H
Sbjct: 357 LLDHGAGIN--THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/105 (31%), Positives = 58/105 (55%), Gaps = 2/105 (1%)
Query: 4 LLINYGADVNLRC--ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
+L++ GADVN ++ TAL AA G +L++ GAH D ++ G TPL LA+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE 106
GH +++++L++ GA+ + + L+ A G+ V L++
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 43.1 bits (100), Expect = 5e-04
Identities = 23/71 (32%), Positives = 41/71 (57%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LLI+ GA +++R T L A+ G D+V+L++ +GA D TPL A + G
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 64 HTEIMEMLLRK 74
H ++++ L+++
Sbjct: 1370 HVKVVQYLVKE 1380
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 98.6 bits (244), Expect = 9e-21
Identities = 79/267 (29%), Positives = 123/267 (46%), Gaps = 34/267 (12%)
Query: 17 ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGA 76
+N TAL A G E++V +++ A + + GFTPL LAA +GH ++E+LL KG
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 77 NAHGQASDSSSILLE-AASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
+ Q+ + L A SGG + V LLL GA+ S + P+ +AA G++ +K
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 136 ILIPV---TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN--------------- 177
IL+ + + GISP+ AA H ++LL+ G D+N
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
Query: 178 ---------FMLDQRIN-KHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---- 223
+LD++ N +H + L A S ++LL GA N PV
Sbjct: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 224 -NCLQIALRMGNYELISLLLRHGANVN 249
L IA G+Y+ LL+ GA+++
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.3 bits (238), Expect = 5e-20
Identities = 82/281 (29%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + A TAL A G D+VK++L GA+ + + G TPL AA +G
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ +L +
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQG--------ANINAQTEETQETALTLACCGGFSEVA 521
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 522 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/237 (29%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T L A+ G D+VKL+L+ A + QS G T L A G +I+++LL +GAN
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS-GHLPIHVAADRGHLLALKILIP 139
+ + L+EAAS G+ + +LL++GA N N + +A +GHL ++ L+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL- 392
Query: 140 VTDLAAIKQSGISPVHCAAAGA----HPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSA 195
+ A ++ +H A A H + LL+ +G VN D +S
Sbjct: 393 --EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS---------FESP 441
Query: 196 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L A + LL+ GA N + L A R G+ E+++LLL GAN+N
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 87.4 bits (215), Expect = 2e-17
Identities = 95/369 (25%), Positives = 157/369 (42%), Gaps = 44/369 (11%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A +L+++GA +N +NE +AL A G DMV+ +L +GA + ++ T L
Sbjct: 353 VARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA+ + G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFD- 175
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 176 -------------------VNFMLDQRINKHYDDHR-KSALYFAVSNSDLSSVKLLLSAG 215
V ++L N H +AL +A N +LL AG
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 216 A---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVM 272
A ++ L A R G+ + L+ GANVN N H +L +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR-ATANNDHTVVSLACAGGHLAV 650
Query: 273 LRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVR 332
+ +LL +G D P++ ++ ++ +I+ K +S+L V+
Sbjct: 651 VELLLAHGAD--------------PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Query: 333 VMLDYVDQV 341
V V Q+
Sbjct: 697 VPTTDVSQL 705
Score = 86.7 bits (213), Expect = 4e-17
Identities = 65/196 (33%), Positives = 103/196 (52%), Gaps = 6/196 (3%)
Query: 4 LLINYGADVNLRCANER--TALHEAAKLGREDMVKLMLVSGAHPDPQ-STYGFTPLALAA 60
+L+N GA++N R ++ + L AA G VKL+L G+ + Q T T L LA
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPK--NSG 118
G E++ +LL + AN +A + L+EAASGG + +LL+ GAD N P +S
Sbjct: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
Query: 119 HLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
+ +AAD+GH ++LI + + G +P+ A+ G H ++LL+QAG DV+
Sbjct: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
Query: 178 FMLDQRINKHYDDHRK 193
+++I RK
Sbjct: 1353 AADNRKITPLMSAFRK 1368
Score = 63.9 bits (154), Expect = 3e-10
Identities = 42/140 (30%), Positives = 75/140 (53%), Gaps = 2/140 (1%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGA--HPDPQSTYGFTPLAL 58
+ +LL++ A+V R T L EAA G ++ +++L GA + P + T L +
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
AA GH + E+L+ +GA+ + ++ L A++GG+ D V LL++ GAD + N
Sbjct: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
Query: 119 HLPIHVAADRGHLLALKILI 138
P+ A +GH+ ++ L+
Sbjct: 1359 ITPLMSAFRKGHVKVVQYLV 1378
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/292 (26%), Positives = 118/292 (40%), Gaps = 26/292 (8%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSG-AHPDPQSTYGFTPLALAAQSGHTEI 67
GAD LR + T A L + KL G A DP+ T A
Sbjct: 132 GAD--LRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
Query: 68 MEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAAD 127
+ + K N+H + L EA S G+ +AV LL+ G N G + +A
Sbjct: 190 LTRM--KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
Query: 128 RGHLLALKILIPVTDLAAIKQSG----ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
G+ ++L+ + A ++ G I+P+ A++G + ++LL+ DVN
Sbjct: 248 AGYYELAQVLLAMH--ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN------ 299
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGAL---PNQDPVNCLQIALRMGNYELISL 240
+AL +A + + VK+LL+ GA N++ L A G+ E+ +
Sbjct: 300 ---SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 241 LLRHGANVNYFCRVNPLHFPSALQYTLKDEV-MLRMLLNYGYDTERCFDCPH 291
LL HGA +N N + K + M+R LL G D E D H
Sbjct: 357 LLDHGAGIN--THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/105 (31%), Positives = 58/105 (55%), Gaps = 2/105 (1%)
Query: 4 LLINYGADVNLRC--ANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
+L++ GADVN ++ TAL AA G +L++ GAH D ++ G TPL LA+
Sbjct: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE 106
GH +++++L++ GA+ + + L+ A G+ V L++
Sbjct: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 43.1 bits (100), Expect = 5e-04
Identities = 23/71 (32%), Positives = 41/71 (57%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LLI+ GA +++R T L A+ G D+V+L++ +GA D TPL A + G
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 64 HTEIMEMLLRK 74
H ++++ L+++
Sbjct: 1370 HVKVVQYLVKE 1380
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 97.1 bits (240), Expect = 3e-20
Identities = 78/255 (30%), Positives = 123/255 (48%), Gaps = 18/255 (7%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L++ GA VN +N RT L AA G D+V L++ GA + + +G TPL LAA+ GH
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHV 124
T+++ L+ GAN + D + L AA GG+ + V+ LL G + +
Sbjct: 591 TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
Query: 125 AADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
AA GH + L +L ++ G + + AA H + +E L+ G +VN
Sbjct: 651 AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN------ 704
Query: 184 INKHYDDHRKSALYFA-----VSNSDLSSVKLLLSAGALP---NQDPVNCLQIALRMGNY 235
H D ++AL A S S V LL+ GA ++D + L +A G+
Sbjct: 705 ---HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
Query: 236 ELISLLLRHGANVNY 250
+++ LLL GA+V++
Sbjct: 762 DVVDLLLEGGADVDH 776
Score = 94.7 bits (234), Expect = 1e-19
Identities = 74/254 (29%), Positives = 122/254 (48%), Gaps = 18/254 (7%)
Query: 5 LINYGADVNLRCANERTALHEAA-----KLGREDMVKLMLVSGAHPDPQSTYGFTPLALA 59
L+++GA+VN + RTAL AA G +V L++ GA D G TPL +A
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
Query: 60 AQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGH 119
A GH +++++LL GA+ ++ + LL AAS G+ V LL +GA + + G
Sbjct: 756 AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815
Query: 120 LPIHVAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
+ +A+ +G++ ++ L+ D +G +P+H AA H E LI+ G N
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN- 874
Query: 179 MLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQ---DPVNCLQIALRMGNY 235
D+ + A V++LL + +Q D N L++A G+
Sbjct: 875 --------EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
Query: 236 ELISLLLRHGANVN 249
+++ LL HGA+VN
Sbjct: 927 DIVELLFSHGADVN 940
Score = 92.8 bits (229), Expect = 5e-19
Identities = 82/289 (28%), Positives = 126/289 (43%), Gaps = 51/289 (17%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL++ GAD+ + A+ T L AA+ G +V ++ GA+ + G+T L AA G
Sbjct: 563 LLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGG 622
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG----- 118
HTE++ LL G +DS + L AA GG+ D V LL++GA+ N N G
Sbjct: 623 HTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALI 682
Query: 119 ------------HLPIH---------------------VAADRGHLLALKILIP-VTDLA 144
HL H V A +GH + +LI ++
Sbjct: 683 AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
Query: 145 AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD 204
+ G++P+ AA H ++LL++ G DV+ H D++ ++ L A S
Sbjct: 743 HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD---------HTDNNGRTPLLAAASMGH 793
Query: 205 LSSVKLLLSAGALP---NQDPVNCLQIALRMGNYELISLLLRHGANVNY 250
S V LL GA + + L IA GN E++ LL G + N+
Sbjct: 794 ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Score = 91.7 bits (226), Expect = 1e-18
Identities = 81/252 (32%), Positives = 116/252 (46%), Gaps = 13/252 (5%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+ +LLI+ GA+V+ + T L AA G D+V L+L GA D G TPL AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
GH ++ LL GA S+ ++L A++ GN + V LL+ G D N ++G
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 121 PIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
P+H+AA GH L + LI I G P A+ H C+++L++ ++
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI--- 906
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYE 236
DQR YD ++AL A V+LL S GA N D L I
Sbjct: 907 -DQR---GYDG--RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 237 LISLLLRHGANV 248
+ L +GANV
Sbjct: 961 MAEYFLENGANV 972
Score = 84.7 bits (208), Expect = 1e-16
Identities = 70/258 (27%), Positives = 120/258 (46%), Gaps = 13/258 (5%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
LI GA N + R A++ G D V+++L + ++ D + G L +AA GH
Sbjct: 866 LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGH 925
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHV 124
+I+E+L GA+ + + +D L A LE GA+ G +HV
Sbjct: 926 RDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHV 985
Query: 125 AADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
+ +GH+ +++LI D+ A S + AA H + ++LLI+ G V+
Sbjct: 986 SCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD------ 1039
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISL 240
H + +AL A + V++LL GA PN Q +++A + G+ ++I L
Sbjct: 1040 ---HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 1096
Query: 241 LLRHGANVNYFCRVNPLH 258
L ++GA+ C +P+H
Sbjct: 1097 LEKYGASSLNGCSPSPVH 1114
Score = 83.2 bits (204), Expect = 4e-16
Identities = 77/282 (27%), Positives = 129/282 (45%), Gaps = 33/282 (11%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+ + L+ G V+ A+ RTAL AA G ED+V +L GA + G T L AA
Sbjct: 626 VVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAA 685
Query: 61 QSGHTEIMEMLLRKGANAH-----GQASDSSSILLEAASGGNPDAVALLLEYGADANIPK 115
GH EI+E LL GA + G+ + S + L AS G+ V+LL++ GA+ +
Sbjct: 686 YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD 745
Query: 116 NSGHLPIHVAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGF 174
G P+ VAA GH+ + +L+ D+ +G +P+ AA+ H + L+ G
Sbjct: 746 KDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA 805
Query: 175 DVN-----------------------FMLDQRINK-HYDDHRKSALYFAVSNSDLSSVKL 210
V+ +LD+ +++ H DD + L+ A +
Sbjct: 806 AVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
Query: 211 LLSAGALPNQ---DPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ GA N+ D +A + G+Y+ + +LL + +N++
Sbjct: 866 LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Score = 76.3 bits (186), Expect = 5e-14
Identities = 51/171 (29%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL ++GADVN + A+ R L+ A + M + L +GA+ + G T L ++ G
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H E++++L+ A+ + ++ S L AA G+ V LL+E+GA + N G +
Sbjct: 991 HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALC 1050
Query: 124 VAADRGHLLALKILIP-VTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAG 173
+AA GH+ +++L+ D Q G + + AA H Q ++LL + G
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
Score = 73.2 bits (178), Expect = 4e-13
Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 1/155 (0%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
MA + GA+V A RTALH + G +MV++++ A + + L AA
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
GH +++++L+ GA + ++ L AA G+ D V +LLE+GAD N G
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
Query: 121 PIHVAADRGHLLALKILIPVTDLAAIKQSGISPVH 155
+ VAA GH +K L+ +++ SPVH
Sbjct: 1081 AMRVAAKNGHSQIIK-LLEKYGASSLNGCSPSPVH 1114
Score = 68.9 bits (167), Expect = 8e-12
Identities = 56/216 (25%), Positives = 95/216 (43%), Gaps = 14/216 (6%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+L+ ++++ R + R AL AA G D+V+L+ GA + + G L + A
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
+ E L GAN ++ + L + G+ + V +L+ Y AD N N +
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 124 VAADRGHLLALKILI---PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 180
AA +GH+ +++LI V D G + + AA H +++L++ G D N
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTC--NQGATALCIAAQEGHIDVVQVLLEHGADPN--- 1072
Query: 181 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA 216
H D ++A+ A N +KLL GA
Sbjct: 1073 ------HADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 96.3 bits (238), Expect = 5e-20
Identities = 82/281 (29%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + A TAL A G D+VK++L GA+ + + G TPL AA +G
Sbjct: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ +L +
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQG--------ANINAQTEETQETALTLACCGGFSEVA 521
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 522 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 562
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/237 (29%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T L A+ G D+VKL+L+ A + QS G T L A G +I+++LL +GAN
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS-GHLPIHVAADRGHLLALKILIP 139
+ + L+EAAS G+ + +LL++GA N N + +A +GHL ++ L+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL- 392
Query: 140 VTDLAAIKQSGISPVHCAAAGA----HPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSA 195
+ A ++ +H A A H + LL+ +G VN D +S
Sbjct: 393 --EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS---------FESP 441
Query: 196 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L A + LL+ GA N + L A R G+ E+++LLL GAN+N
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 84.0 bits (206), Expect = 2e-16
Identities = 72/256 (28%), Positives = 120/256 (46%), Gaps = 20/256 (7%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A +L+++GA +N +NE +AL A G DMV+ +L +GA + ++ T L
Sbjct: 353 VARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA+ + G
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDV 176
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D+
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMG 233
+ L A L VK LL++GA + L A G
Sbjct: 532 ELGC------------STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Query: 234 NYELISLLLRHGANVN 249
+ ++ +LL+ GA+++
Sbjct: 580 HTDVADVLLQAGADLD 595
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/292 (26%), Positives = 118/292 (40%), Gaps = 26/292 (8%)
Query: 9 GADVNLRCANERTALHEAAKLGREDMVKLMLVSG-AHPDPQSTYGFTPLALAAQSGHTEI 67
GAD LR + T A L + KL G A DP+ T A
Sbjct: 132 GAD--LRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
Query: 68 MEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAAD 127
+ + K N+H + L EA S G+ +AV LL+ G N G + +A
Sbjct: 190 LTRM--KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
Query: 128 RGHLLALKILIPVTDLAAIKQSG----ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
G+ ++L+ + A ++ G I+P+ A++G + ++LL+ DVN
Sbjct: 248 AGYYELAQVLLAMH--ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN------ 299
Query: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGAL---PNQDPVNCLQIALRMGNYELISL 240
+AL +A + + VK+LL+ GA N++ L A G+ E+ +
Sbjct: 300 ---SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 241 LLRHGANVNYFCRVNPLHFPSALQYTLKDEV-MLRMLLNYGYDTERCFDCPH 291
LL HGA +N N + K + M+R LL G D E D H
Sbjct: 357 LLDHGAGIN--THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Score = 56.6 bits (135), Expect = 4e-08
Identities = 34/89 (38%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LI GAD+ L C+ T L EA++ G ++VK +L SGA+ + G T L A
Sbjct: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSIL 89
++GHT++ ++LL+ GA+ Q D +IL
Sbjct: 577 ENGHTDVADVLLQAGADLDKQ-EDMKTIL 604
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 96.3 bits (238), Expect = 5e-20
Identities = 82/281 (29%), Positives = 124/281 (44%), Gaps = 43/281 (15%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+ + ADVN + A TAL A G D+VK++L GA+ + + G TPL AA +G
Sbjct: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
Query: 64 HTEIMEMLLRKGA--NAHGQASDSSSI--------------------------------L 89
H E+ +LL GA N H S++ L
Sbjct: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398
Query: 90 LEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQ 148
+EA G+ + LLL+ GA N+P +S P+ +AA GH+ LA ++ +L +
Sbjct: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458
Query: 149 SGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSV 208
G +P+ AA H + + LL+ G IN ++ +++AL A
Sbjct: 459 EGYTPLMEAAREGHEEMVALLLAQG--------ANINAQTEETQETALTLACCGGFSEVA 510
Query: 209 KLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L+ AGA L A + G+ EL+ LL GANV+
Sbjct: 511 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVH 551
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/237 (29%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 21 TALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHG 80
T L A+ G D+VKL+L+ A + QS G T L A G +I+++LL +GAN
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 81 QASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS-GHLPIHVAADRGHLLALKILIP 139
+ + L+EAAS G+ + +LL++GA N N + +A +GHL ++ L+
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL- 381
Query: 140 VTDLAAIKQSGISPVHCAAAGA----HPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSA 195
+ A ++ +H A A H + LL+ +G VN D +S
Sbjct: 382 --EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS---------FESP 430
Query: 196 LYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVN 249
L A + LL+ GA N + L A R G+ E+++LLL GAN+N
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
Score = 84.0 bits (206), Expect = 2e-16
Identities = 72/256 (28%), Positives = 120/256 (46%), Gaps = 20/256 (7%)
Query: 1 MAALLINYGADVNLRCANE--RTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLAL 58
+A +L+++GA +N +NE +AL A G DMV+ +L +GA + ++ T L
Sbjct: 342 VARVLLDHGAGINTH-SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 59 AAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSG 118
A GH E+ +LL GA + A S L AA GG+ + ALL+E GA+ + G
Sbjct: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
Query: 119 HLPIHVAADRGH--LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDV 176
+ P+ AA GH ++AL + A +++ + + A G + + LI+AG D+
Sbjct: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMG 233
+ L A L VK LL++GA + L A G
Sbjct: 521 ELGC------------STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 568
Query: 234 NYELISLLLRHGANVN 249
+ ++ +LL+ GA+++
Sbjct: 569 HTDVADVLLQAGADLD 584
Score = 56.6 bits (135), Expect = 4e-08
Identities = 34/89 (38%), Positives = 53/89 (59%), Gaps = 4/89 (4%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
+A LI GAD+ L C+ T L EA++ G ++VK +L SGA+ + G T L A
Sbjct: 509 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSIL 89
++GHT++ ++LL+ GA+ Q D +IL
Sbjct: 566 ENGHTDVADVLLQAGADLDKQ-EDMKTIL 593
Score = 56.2 bits (134), Expect = 5e-08
Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 23/265 (8%)
Query: 35 VKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAAS 94
++ +L + A DP+ T A + + K N+H + L EA S
Sbjct: 146 LEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRM--KAENSHNAGQVDTRSLAEACS 203
Query: 95 GGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSG---- 150
G+ +AV LL+ G N G + +A G+ ++L+ + A ++ G
Sbjct: 204 DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH--ANVEDRGNKGD 261
Query: 151 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL 210
I+P+ A++G + ++LL+ DVN +AL +A + + VK+
Sbjct: 262 ITPLMAASSGGYLDIVKLLLLHDADVN---------SQSATGNTALTYACAGGFVDIVKV 312
Query: 211 LLSAGAL---PNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTL 267
LL+ GA N++ L A G+ E+ +LL HGA +N N +
Sbjct: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN--THSNEFKESALTLACY 370
Query: 268 KDEV-MLRMLLNYGYDTERCFDCPH 291
K + M+R LL G D E D H
Sbjct: 371 KGHLDMVRFLLEAGADQEHKTDEMH 395
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 94.7 bits (234), Expect = 1e-19
Identities = 85/293 (29%), Positives = 128/293 (43%), Gaps = 31/293 (10%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
M LL+ GA++N +R ALH AA +G D+V L++ GA + G+TPL AA
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
+G +++ LL G ++ L A G V L++YGA+ N P N+G
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Query: 121 PIHVAADRGH-LLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNF 178
P+H AA H L L++L+ D+ + G SP+H A + LIQ G +++
Sbjct: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 309
Query: 179 ------------------MLDQRINKHYDD------HRKSALYFAVSNSDLSSVKLLLSA 214
+L + D H L+ A N+ + LLS+
Sbjct: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 215 G---ALPNQDPVNCLQIALRMGNYELISLLLRHGANVNY--FCRVNPLHFPSA 262
G P++ CL A GN E I LL GA+ + C PLH+ +A
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Score = 90.1 bits (222), Expect = 3e-18
Identities = 77/285 (27%), Positives = 134/285 (47%), Gaps = 18/285 (6%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
+LI+ DVN + +RT LH AA LG ++++L+++SGA + + TPL A S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
E +++L++ A+ + + + + L AA+ +++ + N+ G +H
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 124 VAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
AA GH+ + +L+ ++ A + +H AA H + LLI G +V
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--- 177
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPV---NCLQIALRMGNYELIS 239
D + L+ A SN ++ VK LL+ G ++ V L IA G +++
Sbjct: 178 ------DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231
Query: 240 LLLRHGANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYD 282
L+ +GANVN PLHF +A + + L +L+N G D
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAA---STHGALCLELLVNNGAD 273
Score = 87.8 bits (216), Expect = 2e-17
Identities = 78/282 (27%), Positives = 130/282 (46%), Gaps = 15/282 (5%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LL+N GADVN++ + ++ LH A GR + ++ +G D G TPL +AA+ G
Sbjct: 266 LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYG 325
Query: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
H ++ L GA+ S L AA + D LL G + + P G +H
Sbjct: 326 HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 124 VAADRGHLLALKIL-IPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ 182
AA G++ +K+L D + G +P+H AAA H C+E L+ G +VN
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN----- 440
Query: 183 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLL 242
DD ++AL++A + SD+ K +L A N + + + + LL
Sbjct: 441 ----ETDDWGRTALHYAAA-SDMDRNKTIL-GNAHDNSEELERARELKEKEATLCLEFLL 494
Query: 243 RHGANVNYFCR--VNPLHFPSALQYTLKDEVMLRMLLNYGYD 282
++ AN + + N +H+ +A + E++L N G++
Sbjct: 495 QNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFE 535
Score = 85.1 bits (209), Expect = 1e-16
Identities = 80/288 (27%), Positives = 126/288 (43%), Gaps = 16/288 (5%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
A ++I + VN+ RTALH AA G +MV L+L GA+ + L AA
Sbjct: 98 AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
Query: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLP 121
GH +++ +L+ GA + + L AAS G + V LL G + + G+
Sbjct: 158 MGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTA 217
Query: 122 IHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAH-PQCLELLIQAGFDVNFM 179
+H+A G + LI ++ +G +P+H AAA H CLELL+ G DVN
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYE 236
KS L+ + + + L+ G ++D L +A R G+
Sbjct: 278 ---------SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 328
Query: 237 LISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
LI+ L GA+ C ++ + FP L R LL+ G++ +
Sbjct: 329 LINTLRTSGADTAK-CGIHSM-FPLHLAALNAHSDCCRKLLSSGFEID 374
Score = 79.7 bits (195), Expect = 5e-15
Identities = 73/261 (27%), Positives = 113/261 (43%), Gaps = 29/261 (11%)
Query: 5 LINYGADVNLRC-ANERTALHEAAKLGREDMVKLMLVSGAHP---DPQSTYGFTPLALAA 60
LIN GA + ++ +RT LH + G ++L+L +P D + G TPL LA
Sbjct: 594 LINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
GH + + +LL K AN + L G+ + V +LLE + G
Sbjct: 654 AYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713
Query: 121 PIHVAADRGHLLALKILIPVT----DLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDV 176
P+H AA RGH L L+ + D G +P+H A + C+E+L
Sbjct: 714 PLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL------- 766
Query: 177 NFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC--------LQI 228
L+Q+ + + + + L+ A+ N + LLL A + V+C L+
Sbjct: 767 ---LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGA---IDSSIVSCRDDKGRTPLRA 820
Query: 229 ALRMGNYELISLLLRHGANVN 249
A + E + LLLRH A VN
Sbjct: 821 AAFADHVECLQLLLRHSAPVN 841
Score = 72.8 bits (177), Expect = 6e-13
Identities = 82/307 (26%), Positives = 128/307 (41%), Gaps = 62/307 (20%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
L++ G +++ RT LH AA G + +KL+ SGA + G TPL AA + H
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425
Query: 65 TEIMEMLLRKGANAH-------------------------GQASDSSSILLEAASGGNPD 99
+E L+ GAN + G A D+S L A +
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 100 A---VALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQ-SGI--SP 153
A + LL+ A+ +I G+ IH AA GH L++L+ T+ + SG SP
Sbjct: 486 ATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSP 545
Query: 154 VHCAAAGAHPQCLELLIQAGFDVNFM-------LDQRINKHYDD---------------- 190
+H AA H Q LE+L+Q+ D++ LD K + +
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 191 --HRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC------LQIALRMGNYELISLLL 242
+++ L+ +V N ++LLL P V L +A+ G+ + +SLLL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 243 RHGANVN 249
ANV+
Sbjct: 666 EKEANVD 672
Score = 67.4 bits (163), Expect = 2e-11
Identities = 82/343 (23%), Positives = 135/343 (39%), Gaps = 69/343 (20%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
LI G +++ + T LH AA+ G E ++ + SGA + PL LAA + H
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHV 124
++ LL G + L AA+GGN + + LL GAD + G P+H
Sbjct: 360 SDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHY 419
Query: 125 AADRGHLLALKILIPVTDLAAIKQS---GISPVHCAAA-----------GAHPQ------ 164
AA H ++ L VT A + ++ G + +H AAA AH
Sbjct: 420 AAANCHFHCIETL--VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 477
Query: 165 -----------CLELLIQAGFDVNF----------------------MLDQRINKHYDDH 191
CLE L+Q + + +L +R N +++
Sbjct: 478 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEES 537
Query: 192 ----RKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRH 244
KS L+ A N ++++LL + + ++ L +A G+ E + L+
Sbjct: 538 DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
Query: 245 GANV---NYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTE 284
GA++ + + PLH +TL LR+LL + E
Sbjct: 598 GASIFVKDNVTKRTPLHASVINGHTL----CLRLLLEIADNPE 636
Score = 65.9 bits (159), Expect = 7e-11
Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 15/218 (6%)
Query: 12 VNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEML 71
V+++ A +T L A G D V L+L A+ D G T L +GH E ++ML
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 72 LRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG---ADANIPKNSGHLPIHVAADR 128
L + + + S + L AA+ G+ ++ LL+ D N G+ P+H A
Sbjct: 698 LEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYN 757
Query: 129 GHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHY 188
G+ +++L+ + +P+HCA H C LL+ A +D I
Sbjct: 758 GNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGA-------IDSSIVSCR 810
Query: 189 DDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCL 226
DD ++ L A + ++LLL A PVN +
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSA-----PVNAV 843
Score = 49.7 bits (117), Expect = 5e-06
Identities = 32/99 (32%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 52 GFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG-AD 110
G TPL AA + H E +++LLR A + + + L+ AA G AV +L+ AD
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873
Query: 111 ANIPKNSGHLPIHVAADRGH-LLALKILIPVTDLAAIKQ 148
+ + P+H+A +GH AL IL + D + I +
Sbjct: 874 LTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 94.4 bits (233), Expect = 2e-19
Identities = 50/138 (36%), Positives = 76/138 (55%)
Query: 1 MAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
++ LL G D+N C + +AL+ AAK G D V+L+L + A + GFTPL AA
Sbjct: 726 LSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAA 785
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHL 120
GH E +E+L+ AN + A + L A GN + + LLLE G + ++ G
Sbjct: 786 AQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT 845
Query: 121 PIHVAADRGHLLALKILI 138
P+H A D G++ +LK+L+
Sbjct: 846 PVHAAVDTGNVDSLKLLM 863
Score = 75.1 bits (183), Expect = 1e-13
Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 16/198 (8%)
Query: 52 GFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLL-EYGAD 110
G + L SG + + LL G A + ++L +AA+ GN +++LL E G D
Sbjct: 679 GASDSLLVTASGWSPSLTPLLMSGGPA--PLAGRPTLLQQAAAQGNVTLLSMLLNEEGLD 736
Query: 111 ANIPKNSGHLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELL 169
N GH ++ AA GH +++L+ + A ++G +P+ AAA H +C+ELL
Sbjct: 737 INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL 796
Query: 170 IQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAG---ALPNQDPVNCL 226
I ++N H D ++ LY A N + +KLLL AG ++ D +
Sbjct: 797 ISYDANIN---------HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV 847
Query: 227 QIALRMGNYELISLLLRH 244
A+ GN + + LL+ H
Sbjct: 848 HAAVDTGNVDSLKLLMYH 865
Score = 63.2 bits (152), Expect = 4e-10
Identities = 43/156 (27%), Positives = 78/156 (50%), Gaps = 2/156 (1%)
Query: 17 ANERTALHEAAKLGREDMVKLML-VSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKG 75
A T L +AA G ++ ++L G + G + L AA++GHT+ + +LL
Sbjct: 708 AGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAE 767
Query: 76 ANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALK 135
A + + + L AA+ G+ + V LL+ Y A+ N + G P+++A G+ +K
Sbjct: 768 AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIK 827
Query: 136 ILIPVTDLAAIKQS-GISPVHCAAAGAHPQCLELLI 170
+L+ ++K + G +PVH A + L+LL+
Sbjct: 828 LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
Score = 59.7 bits (143), Expect = 5e-09
Identities = 38/138 (27%), Positives = 72/138 (52%), Gaps = 4/138 (2%)
Query: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
LLI+Y A++N +T L+ A K G ++ +KL+L +G + ++T G+TP+ A +G
Sbjct: 795 LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG 854
Query: 64 HTEIMEMLLRKGANAHGQA---SDSSSILLEAASG-GNPDAVALLLEYGADANIPKNSGH 119
+ + +++L+ AHG + +S S + + G +P+ ++ + N G
Sbjct: 855 NVDSLKLLMYHRIPAHGNSFNEEESESSVFDLDGGEESPEGISKPVVPADLINHANREGW 914
Query: 120 LPIHVAADRGHLLALKIL 137
H+AA +G L+IL
Sbjct: 915 TAAHIAASKGFKNCLEIL 932
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 92.8 bits (229), Expect = 5e-19
Identities = 68/241 (28%), Positives = 104/241 (43%), Gaps = 46/241 (19%)
Query: 11 DVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEM 70
D+N+ TALH AA G VKL+L + A D TPL A + GH ++++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 71 LLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGH 130
L++ GA D S+L AA GGN D +L+E + N+ +G
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR----------- 457
Query: 131 LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+P+ CAA G + C+ +L++ D N D
Sbjct: 458 ---------------------TPLQCAAYGGYINCMAVLMENNADPNIQ---------DK 487
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQ-----DPVNCLQIALRMGNYELISLLLRHG 245
++AL+++ +N L ++KLLL A PNQ + L AL +E+I +L HG
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Query: 246 A 246
A
Sbjct: 548 A 548
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/256 (25%), Positives = 113/256 (44%), Gaps = 21/256 (8%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
A L+ GADVN ++RTALH AA+ G +KL+L A+ + TPL L +
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
Query: 62 SGHTEIMEMLLRKGANAHGQASDSS--SILLEAASGGNPDAVALLLEYGADANIPKNSGH 119
+ + +LL+ A D + + L +A NP+ V LL+++ ++ IP G
Sbjct: 124 HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK 183
Query: 120 LPIHVAADRGHLLALKILIPVTDLAAIKQ-------SGISPVHCAAAGAHPQCLELLIQA 172
+P+H AA+ A+ + + D A + G +P+H A A + +++L
Sbjct: 184 IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS- 242
Query: 173 GFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDP-VNCLQI 228
+ YD+ ++ L++A V LLL +G +P+ L
Sbjct: 243 -------YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHY 295
Query: 229 ALRMGNYELISLLLRH 244
A + E + + L+H
Sbjct: 296 AAQSNFAETVKVFLKH 311
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/113 (30%), Positives = 60/113 (53%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
LI GA V+L + + LH AA G D+ ++++ + +P+ Q G TPL AA G+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS 117
M +L+ A+ + Q + + L + + G DA+ LLL++ A N +N+
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 99 DAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGI---SPVH 155
D LL+ GAD N +S +H+AA +G+ +K+L+ T A Q + +P+H
Sbjct: 62 DCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLL--TRRANWMQKDLEEMTPLH 119
Query: 156 CAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLL 212
P+CL LL++ FM ++ D ++++AL+++ ++ VKLL+
Sbjct: 120 LTTRHRSPKCLALLLK------FMAPGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLI 169
Score = 42.4 bits (98), Expect = 8e-04
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 2/96 (2%)
Query: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPD--PQSTYGFTPLALAA 60
A+L+ AD N++ RTALH + G D +KL+L A P+ + +TPL A
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGG 96
E+++ +L GA + D ++ ++A G
Sbjct: 533 LGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKG 568
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 92.8 bits (229), Expect = 5e-19
Identities = 68/241 (28%), Positives = 104/241 (43%), Gaps = 46/241 (19%)
Query: 11 DVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEM 70
D+N+ TALH AA G VKL+L + A D TPL A + GH ++++
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408
Query: 71 LLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGH 130
L++ GA D S+L AA GGN D +L+E + N+ +G
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGR----------- 457
Query: 131 LLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDD 190
+P+ CAA G + C+ +L++ D N D
Sbjct: 458 ---------------------TPLQCAAYGGYINCMAVLMENNADPNIQ---------DK 487
Query: 191 HRKSALYFAVSNSDLSSVKLLLSAGALPNQ-----DPVNCLQIALRMGNYELISLLLRHG 245
++AL+++ +N L ++KLLL A PNQ + L AL +E+I +L HG
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Query: 246 A 246
A
Sbjct: 548 A 548
Score = 66.6 bits (161), Expect = 4e-11
Identities = 65/256 (25%), Positives = 113/256 (44%), Gaps = 21/256 (8%)
Query: 2 AALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQ 61
A L+ GADVN ++RTALH AA+ G +KL+L A+ + TPL L +
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTR 123
Query: 62 SGHTEIMEMLLRKGANAHGQASDSS--SILLEAASGGNPDAVALLLEYGADANIPKNSGH 119
+ + +LL+ A D + + L +A NP+ V LL+++ ++ IP G
Sbjct: 124 HRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGK 183
Query: 120 LPIHVAADRGHLLALKILIPVTDLAAIKQ-------SGISPVHCAAAGAHPQCLELLIQA 172
+P+H AA+ A+ + + D A + G +P+H A A + +++L
Sbjct: 184 IPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS- 242
Query: 173 GFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLL---SAGALPNQDP-VNCLQI 228
+ YD+ ++ L++A V LLL +G +P+ L
Sbjct: 243 -------YESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHY 295
Query: 229 ALRMGNYELISLLLRH 244
A + E + + L+H
Sbjct: 296 AAQSNFAETVKVFLKH 311
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/113 (30%), Positives = 60/113 (53%)
Query: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGH 64
LI GA V+L + + LH AA G D+ ++++ + +P+ Q G TPL AA G+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468
Query: 65 TEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNS 117
M +L+ A+ + Q + + L + + G DA+ LLL++ A N +N+
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 99 DAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGI---SPVH 155
D LL+ GAD N +S +H+AA +G+ +K+L+ T A Q + +P+H
Sbjct: 62 DCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLL--TRRANWMQKDLEEMTPLH 119
Query: 156 CAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLL 212
P+CL LL++ FM ++ D ++++AL+++ ++ VKLL+
Sbjct: 120 LTTRHRSPKCLALLLK------FMAPGEVDTQ-DKNKQTALHWSAYYNNPEHVKLLI 169
Score = 42.4 bits (98), Expect = 8e-04
Identities = 28/96 (29%), Positives = 47/96 (48%), Gaps = 2/96 (2%)
Query: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPD--PQSTYGFTPLALAA 60
A+L+ AD N++ RTALH + G D +KL+L A P+ + +TPL A
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Query: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGG 96
E+++ +L GA + D ++ ++A G
Sbjct: 533 LGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKG 568
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,581,850
Number of Sequences: 37866
Number of extensions: 665404
Number of successful extensions: 5116
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 329
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 1366
Number of HSP's gapped (non-prelim): 1843
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.