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Search of human proteins with 216547519
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|216547519 interleukin-1 receptor-associated kinase 3 isoform
a [Homo sapiens]
(596 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|216547519 interleukin-1 receptor-associated kinase 3 isoform ... 1222 0.0
gi|216547504 interleukin-1 receptor-associated kinase 3 isoform ... 1006 0.0
gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1... 189 5e-48
gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2... 188 1e-47
gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3... 171 2e-42
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 160 4e-39
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 160 4e-39
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 144 2e-34
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 144 2e-34
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 144 2e-34
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap... 134 2e-31
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 84 3e-16
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 82 1e-15
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 82 1e-15
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 82 1e-15
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 78 2e-14
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 78 2e-14
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 77 3e-14
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 76 8e-14
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 74 5e-13
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 72 2e-12
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 70 4e-12
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 70 4e-12
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 70 4e-12
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 70 4e-12
gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo sap... 70 4e-12
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 70 5e-12
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 70 5e-12
gi|4505001 LIM domain kinase 1 [Homo sapiens] 69 9e-12
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 69 1e-11
>gi|216547519 interleukin-1 receptor-associated kinase 3 isoform a
[Homo sapiens]
Length = 596
Score = 1222 bits (3161), Expect = 0.0
Identities = 596/596 (100%), Positives = 596/596 (100%)
Query: 1 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK 60
MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK
Sbjct: 1 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK 60
Query: 61 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG 120
YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG
Sbjct: 61 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG 120
Query: 121 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY 180
FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY
Sbjct: 121 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY 180
Query: 181 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI 240
RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI
Sbjct: 181 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI 240
Query: 241 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL 300
YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL
Sbjct: 241 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL 300
Query: 301 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF 360
LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF
Sbjct: 301 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF 360
Query: 361 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC 420
GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC
Sbjct: 361 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC 420
Query: 421 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE 480
LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE
Sbjct: 421 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE 480
Query: 481 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE 540
DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE
Sbjct: 481 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE 540
Query: 541 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE 596
ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
Sbjct: 541 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE 596
>gi|216547504 interleukin-1 receptor-associated kinase 3 isoform b
[Homo sapiens]
Length = 535
Score = 1006 bits (2602), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 106 GAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNF 165
GAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNF
Sbjct: 45 GAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNF 104
Query: 166 HKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNIL 225
HKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNIL
Sbjct: 105 HKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNIL 164
Query: 226 ELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQ 285
ELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQ
Sbjct: 165 ELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQ 224
Query: 286 PCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEY 345
PCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEY
Sbjct: 225 PCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEY 284
Query: 346 IRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDK 405
IRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDK
Sbjct: 285 IRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDK 344
Query: 406 KVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRC 465
KVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRC
Sbjct: 345 KVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRC 404
Query: 466 PSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPES 525
PSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPES
Sbjct: 405 PSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPES 464
Query: 526 KRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKF 585
KRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKF
Sbjct: 465 KRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKF 524
Query: 586 SWDEYEQYKKE 596
SWDEYEQYKKE
Sbjct: 525 SWDEYEQYKKE 535
>gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1
[Homo sapiens]
Length = 712
Score = 189 bits (481), Expect = 5e-48
Identities = 156/522 (29%), Positives = 230/522 (44%), Gaps = 85/522 (16%)
Query: 6 GARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQG 65
G A A L+++PP ++ V+D+ + A W A + ++R E+ +
Sbjct: 8 GEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLCERSGQR- 65
Query: 66 KSGTRELLWSWAQKNKTIGDL------LQVLQEMGHRRAIH------------------- 100
T +LW W +N + DL LQ+L+ A H
Sbjct: 66 ---TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIP 122
Query: 101 ------------LITNYGAVLSPSEKSYQEGGFPNI-LFKETANV------TVDNVLIPE 141
L ++ LSP+ Q P + L A++ + P
Sbjct: 123 APAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPG 182
Query: 142 HNEKGILLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFK 195
LL+ + F I GT NF ++ IGEG VYR ++N YAVK K
Sbjct: 183 PESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK 242
Query: 196 QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQC 255
+ ++ + FL+E+E L F HPNI++ A Y + +CL+Y ++ NG+L DRL C
Sbjct: 243 ENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC 302
Query: 256 VGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314
PL W R+ IL+G ++AI +LH P S+I G I S+N+LLD++ PKL DF +
Sbjct: 303 QTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGL 361
Query: 315 A---HFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A F QS + T + L Y+PEEYI+ G+L++ TD +SFG+V++E L G
Sbjct: 362 ARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
Query: 372 RVVLDDPKHIQ-LRDLLRELMEKRGL-----DSCL-------------------SFLDKK 406
R V + L+DL+ E E+ G+ S L LD +
Sbjct: 422 RAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPR 481
Query: 407 VPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQA 448
PCP L LA C RAK RP M +V LE QA
Sbjct: 482 PGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQA 523
>gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2
[Homo sapiens]
Length = 682
Score = 188 bits (477), Expect = 1e-47
Identities = 163/560 (29%), Positives = 244/560 (43%), Gaps = 87/560 (15%)
Query: 6 GARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQG 65
G A A L+++PP ++ V+D+ + A W A + ++R E+ +
Sbjct: 8 GEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLCERSGQR- 65
Query: 66 KSGTRELLWSWAQKNKTIGDL------LQVLQEMGHRRAIH------------------- 100
T +LW W +N + DL LQ+L+ A H
Sbjct: 66 ---TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIP 122
Query: 101 ------------LITNYGAVLSPSEKSYQEGGFPNI-LFKETANV------TVDNVLIPE 141
L ++ LSP+ Q P + L A++ + P
Sbjct: 123 APAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPG 182
Query: 142 HNEKGILLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFK 195
LL+ + F I GT NF ++ IGEG VYR ++N YAVK K
Sbjct: 183 PESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK 242
Query: 196 QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQC 255
+ ++ + FL+E+E L F HPNI++ A Y + +CL+Y ++ NG+L DRL C
Sbjct: 243 ENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC 302
Query: 256 VGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314
PL W R+ IL+G ++AI +LH P S+I G I S+N+LLD++ PKL DF +
Sbjct: 303 QTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGL 361
Query: 315 A---HFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A F QS + T + L Y+PEEYI+ G+L++ TD +SFG+V++E L G
Sbjct: 362 ARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
Query: 372 RVVLDDPKHIQ-LRDLLRELMEKRGL-----DSCL-------------------SFLDKK 406
R V + L+DL+ E E+ G+ S L LD +
Sbjct: 422 RAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPR 481
Query: 407 VPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAE--DPPTSLKSFR 464
PCP L LA C RAK RP M + + + ST + A P +
Sbjct: 482 PGPCPPELGLGLGQLACCCLHRRAKRRPPMTQENSYVSSTGRAHSGAAPWQPLAAPSGAS 541
Query: 465 CPSPLFLENVPSIPVEDDES 484
+ L+ P+ PVE DES
Sbjct: 542 AQAAEQLQRGPNQPVESDES 561
>gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3
[Homo sapiens]
Length = 633
Score = 171 bits (432), Expect = 2e-42
Identities = 128/423 (30%), Positives = 195/423 (46%), Gaps = 60/423 (14%)
Query: 6 GARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQG 65
G A A L+++PP ++ V+D+ + A W A + ++R E+ +
Sbjct: 8 GEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLCERSGQR- 65
Query: 66 KSGTRELLWSWAQKNKTIGDL------LQVLQEMGHRRAIH------------------- 100
T +LW W +N + DL LQ+L+ A H
Sbjct: 66 ---TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIP 122
Query: 101 ------------LITNYGAVLSPSEKSYQEGGFPNI-LFKETANV------TVDNVLIPE 141
L ++ LSP+ Q P + L A++ + P
Sbjct: 123 APAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPG 182
Query: 142 HNEKGILLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFK 195
LL+ + F I GT NF ++ IGEG VYR ++N YAVK K
Sbjct: 183 PESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK 242
Query: 196 QEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQC 255
+ ++ + FL+E+E L F HPNI++ A Y + +CL+Y ++ NG+L DRL C
Sbjct: 243 ENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHC 302
Query: 256 VGDTA-PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAM 314
PL W R+ IL+G ++AI +LH P S+I G I S+N+LLD++ PKL DF +
Sbjct: 303 QTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTPKLGDFGL 361
Query: 315 A---HFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A F QS + T + L Y+PEEYI+ G+L++ TD +SFG+V++E L G
Sbjct: 362 ARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 421
Query: 372 RVV 374
R V
Sbjct: 422 RAV 424
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 160 bits (404), Expect = 4e-39
Identities = 127/455 (27%), Positives = 210/455 (46%), Gaps = 40/455 (8%)
Query: 25 LGELCAVLDSCDGALGWRGLAERLSSSWLD-------VRHIEKYVDQGKSGTRELLWSWA 77
+G + + D D GW+ LA + D +R E + GKS T ELL+ W
Sbjct: 16 VGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWG 75
Query: 78 QKNKTIGDLLQVLQEMGHRRAIHLITNYG----AVLSPSEKSY--QEGGFPNILFKETAN 131
N T+GDL+ +L + L+ A PS+++ Q+ P T
Sbjct: 76 TTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLM 135
Query: 132 VTVDNV---------LIPEHN--EKGILLKSSISFQNIIEGTRNFHKDFL------IGEG 174
V N+ PE+ E S SF + T NF + + +GEG
Sbjct: 136 TPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEG 195
Query: 175 EIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTET 234
VY+ + N T AVK + ++ ++F E++V+ H N++EL + ++
Sbjct: 196 GFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDG 255
Query: 235 EKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSI 294
+ CL+Y YM NG+L DRL C+ T PL WH+R I G + I++LH I I
Sbjct: 256 DDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDI 312
Query: 295 SSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIK 354
SANILLD+ F K++DF +A T + +++ YM E +R G+++ K
Sbjct: 313 KSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTA----YMAPEALR-GEITPK 367
Query: 355 TDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNF 414
+D+YSFG+V++E++TG V + + L D+ E+ ++ + ++DKK+
Sbjct: 368 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEE--KTIEDYIDKKMNDADSTS 425
Query: 415 SAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQAS 449
++ +A +C + RP + +V L+ AS
Sbjct: 426 VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 460
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 160 bits (404), Expect = 4e-39
Identities = 127/455 (27%), Positives = 210/455 (46%), Gaps = 40/455 (8%)
Query: 25 LGELCAVLDSCDGALGWRGLAERLSSSWLD-------VRHIEKYVDQGKSGTRELLWSWA 77
+G + + D D GW+ LA + D +R E + GKS T ELL+ W
Sbjct: 16 VGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWG 75
Query: 78 QKNKTIGDLLQVLQEMGHRRAIHLITNYG----AVLSPSEKSY--QEGGFPNILFKETAN 131
N T+GDL+ +L + L+ A PS+++ Q+ P T
Sbjct: 76 TTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLM 135
Query: 132 VTVDNV---------LIPEHN--EKGILLKSSISFQNIIEGTRNFHKDFL------IGEG 174
V N+ PE+ E S SF + T NF + + +GEG
Sbjct: 136 TPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEG 195
Query: 175 EIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTET 234
VY+ + N T AVK + ++ ++F E++V+ H N++EL + ++
Sbjct: 196 GFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDG 255
Query: 235 EKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSI 294
+ CL+Y YM NG+L DRL C+ T PL WH+R I G + I++LH I I
Sbjct: 256 DDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDI 312
Query: 295 SSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIK 354
SANILLD+ F K++DF +A T + +++ YM E +R G+++ K
Sbjct: 313 KSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTA----YMAPEALR-GEITPK 367
Query: 355 TDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNF 414
+D+YSFG+V++E++TG V + + L D+ E+ ++ + ++DKK+
Sbjct: 368 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEE--KTIEDYIDKKMNDADSTS 425
Query: 415 SAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQAS 449
++ +A +C + RP + +V L+ AS
Sbjct: 426 VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 460
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 144 bits (363), Expect = 2e-34
Identities = 91/304 (29%), Positives = 155/304 (50%), Gaps = 16/304 (5%)
Query: 152 SISFQNIIEGTRNFHKDFL------IGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKH 205
S SF + T NF + + +GEG VY+ + N T AVK + ++
Sbjct: 43 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEEL 102
Query: 206 WKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWH 265
++F E++V+ H N++EL + ++ + CL+Y YM NG+L DRL C+ T PL WH
Sbjct: 103 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH 162
Query: 266 IRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQS 325
+R I G + I++LH I I SANILLD+ F K++DF +A
Sbjct: 163 MRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV 219
Query: 326 CTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRD 385
T + +++ YM E +R G+++ K+D+YSFG+V++E++TG V + + L D
Sbjct: 220 MTSRIVGTTA----YMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD 274
Query: 386 LLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 445
+ E+ ++ + ++DKK+ ++ +A +C + RP + +V L+
Sbjct: 275 IKEEIEDEE--KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
Query: 446 TQAS 449
AS
Sbjct: 333 MTAS 336
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 144 bits (363), Expect = 2e-34
Identities = 91/304 (29%), Positives = 155/304 (50%), Gaps = 16/304 (5%)
Query: 152 SISFQNIIEGTRNFHKDFL------IGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKH 205
S SF + T NF + + +GEG VY+ + N T AVK + ++
Sbjct: 43 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEEL 102
Query: 206 WKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWH 265
++F E++V+ H N++EL + ++ + CL+Y YM NG+L DRL C+ T PL WH
Sbjct: 103 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH 162
Query: 266 IRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQS 325
+R I G + I++LH I I SANILLD+ F K++DF +A
Sbjct: 163 MRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV 219
Query: 326 CTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRD 385
T + +++ YM E +R G+++ K+D+YSFG+V++E++TG V + + L D
Sbjct: 220 MTSRIVGTTA----YMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD 274
Query: 386 LLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 445
+ E+ ++ + ++DKK+ ++ +A +C + RP + +V L+
Sbjct: 275 IKEEIEDEE--KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
Query: 446 TQAS 449
AS
Sbjct: 333 MTAS 336
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 144 bits (363), Expect = 2e-34
Identities = 91/304 (29%), Positives = 155/304 (50%), Gaps = 16/304 (5%)
Query: 152 SISFQNIIEGTRNFHKDFL------IGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKH 205
S SF + T NF + + +GEG VY+ + N T AVK + ++
Sbjct: 43 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEEL 102
Query: 206 WKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWH 265
++F E++V+ H N++EL + ++ + CL+Y YM NG+L DRL C+ T PL WH
Sbjct: 103 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH 162
Query: 266 IRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQS 325
+R I G + I++LH I I SANILLD+ F K++DF +A
Sbjct: 163 MRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV 219
Query: 326 CTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRD 385
T + +++ YM E +R G+++ K+D+YSFG+V++E++TG V + + L D
Sbjct: 220 MTSRIVGTTA----YMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD 274
Query: 386 LLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 445
+ E+ ++ + ++DKK+ ++ +A +C + RP + +V L+
Sbjct: 275 IKEEIEDEE--KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
Query: 446 TQAS 449
AS
Sbjct: 333 MTAS 336
>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
sapiens]
Length = 625
Score = 134 bits (337), Expect = 2e-31
Identities = 110/407 (27%), Positives = 182/407 (44%), Gaps = 34/407 (8%)
Query: 157 NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVL 216
++++ T +F+++ I +G +VYR + K ++ + F +EL++
Sbjct: 202 DVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQIC 261
Query: 217 LLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISK 276
L HPN+L + + + IYPYM NG+L DRLQ G + PLPW R+ I G+
Sbjct: 262 LRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLC 321
Query: 277 AIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSK 336
A+ YLH ++ +I ++ S+N+LLD PKL MAH + T+ T
Sbjct: 322 AVEYLHGLE---IIHSNVKSSNVLLDQNLTPKLA-HPMAHLCPVNKRSKYTMMKTHLLRT 377
Query: 337 HLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRE------- 389
Y+PE++IR G+L+ + D++S GIV+ EVLTG + ++ + L+DLL
Sbjct: 378 SAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTA 437
Query: 390 --LMEKRGLDS------CLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLN 441
K G+++ C +L+K P + + L A C R S+ EV
Sbjct: 438 SLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRR---NTSLQEVCG 494
Query: 442 TLESTQASLYFAED--PPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRID 499
++ + + L E P + L S + P E D+ N++L S
Sbjct: 495 SVAAVEERLRGRETLLPWSGLSEGTGSS-------SNTPEETDDVDNSSLDASSSMSVAP 547
Query: 500 RMTQKTPFECSQSEVMFLSLDKKPESKRNEEAC---NMPSSSCEESW 543
TP +++ L + E+ + EAC P E SW
Sbjct: 548 WAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSW 594
Score = 43.1 bits (100), Expect = 7e-04
Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 17 LFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVD-QGKSGTRELLWS 75
++ LP +L +LC +D+ W A + + +R I+ QG S TRELLW
Sbjct: 5 IYQLPSWVLDDLCRNMDALS-EWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWW 63
Query: 76 WAQKNKTIGDLLQVLQEMGHRRAIHLITNY 105
W + T+ L+ +L + RA +I N+
Sbjct: 64 WGMRQATVQQLVDLLCRLELYRAAQIILNW 93
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 84.3 bits (207), Expect = 3e-16
Identities = 87/361 (24%), Positives = 150/361 (41%), Gaps = 38/361 (10%)
Query: 189 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT 248
Y K Q+K++ KK K E E+L + H NI++ E + ++ Y G+
Sbjct: 31 YRAKWISQDKEVAVKKLLK-IEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGS 89
Query: 249 LFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPK 308
L+D + HI ++K +HYLH P VI + S N+++ K
Sbjct: 90 LYDYINSNRSEEMDMDHIMTWAT-DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLK 148
Query: 309 LTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVL 368
+ DF + F +H H S +M E I+ +S D YS+G+V+ E+L
Sbjct: 149 ICDFGASRFHNHTTHMSLVGTFP--------WMAPEVIQSLPVSETCDTYSYGVVLWEML 200
Query: 369 TGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAAT 428
T V + +Q+ L+ E E+ + S CPR+F+ L +C
Sbjct: 201 TR-EVPFKGLEGLQVAWLVVEKNERLTIPS----------SCPRSFAE----LLHQCWEA 245
Query: 429 RAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKS---FRCPSPLFLENVPSIPVEDDESQ 485
AK RPS ++++ LES + + L + +RC LE + + D +
Sbjct: 246 DAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLE-RDLSFK 304
Query: 486 NNNLLPSDEGLRI--DRMTQKT------PFECSQSEVMFLSLDKKPESKRNEEACNMPSS 537
L + L++ ++T+++ P SE + K ES E +C + ++
Sbjct: 305 EQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEESYFE-SKTEESNSAEMSCQITAT 363
Query: 538 S 538
S
Sbjct: 364 S 364
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 82.4 bits (202), Expect = 1e-15
Identities = 69/257 (26%), Positives = 112/257 (43%), Gaps = 25/257 (9%)
Query: 189 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT 248
Y K Q+K++ KK K E E+L + H NI++ E + ++ Y G+
Sbjct: 31 YRAKWISQDKEVAVKKLLK-IEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGS 89
Query: 249 LFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPK 308
L+D + HI ++K +HYLH P VI + S N+++ K
Sbjct: 90 LYDYINSNRSEEMDMDHIMTWAT-DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLK 148
Query: 309 LTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVL 368
+ DF + F +H H S +M E I+ +S D YS+G+V+ E+L
Sbjct: 149 ICDFGASRFHNHTTHMSLVGTFP--------WMAPEVIQSLPVSETCDTYSYGVVLWEML 200
Query: 369 TGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAAT 428
T V + +Q+ L+ E E+ + S CPR+F+ L +C
Sbjct: 201 TR-EVPFKGLEGLQVAWLVVEKNERLTIPS----------SCPRSFAE----LLHQCWEA 245
Query: 429 RAKLRPSMDEVLNTLES 445
AK RPS ++++ LES
Sbjct: 246 DAKKRPSFKQIISILES 262
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 82.4 bits (202), Expect = 1e-15
Identities = 57/208 (27%), Positives = 101/208 (48%), Gaps = 13/208 (6%)
Query: 165 FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNI 224
FH+ +IG G +VY+ +N A+K ++ K F E+ +L +HP +
Sbjct: 465 FHE--IIGSGSFGKVYKGRCRNKIVAIKRYRANTYCS-KSDVDMFCREVSILCQLNHPCV 521
Query: 225 LE-LAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHN 283
++ + A + +F ++ Y+ G+LF L L ++ I + ++K + YLHN
Sbjct: 522 IQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHN 579
Query: 284 V-QPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMP 342
+ QP +I ++S NILL + + DF + F L+ NMT W P
Sbjct: 580 LTQP--IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED----NMTKQPGNLRWMAP 633
Query: 343 EEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
E + + + +IK DV+S+ + + E+LTG
Sbjct: 634 EVFTQCTRYTIKADVFSYALCLWEILTG 661
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 82.4 bits (202), Expect = 1e-15
Identities = 57/208 (27%), Positives = 101/208 (48%), Gaps = 13/208 (6%)
Query: 165 FHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNI 224
FH+ +IG G +VY+ +N A+K ++ K F E+ +L +HP +
Sbjct: 566 FHE--IIGSGSFGKVYKGRCRNKIVAIKRYRANTYCS-KSDVDMFCREVSILCQLNHPCV 622
Query: 225 LE-LAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHN 283
++ + A + +F ++ Y+ G+LF L L ++ I + ++K + YLHN
Sbjct: 623 IQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGMEYLHN 680
Query: 284 V-QPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMP 342
+ QP +I ++S NILL + + DF + F L+ NMT W P
Sbjct: 681 LTQP--IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED----NMTKQPGNLRWMAP 734
Query: 343 EEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
E + + + +IK DV+S+ + + E+LTG
Sbjct: 735 EVFTQCTRYTIKADVFSYALCLWEILTG 762
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 78.2 bits (191), Expect = 2e-14
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 29/221 (13%)
Query: 170 LIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAA 229
LIG G +VYR Q AVK +Q+ + + E + + HPNI+EL
Sbjct: 129 LIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRG 188
Query: 230 YFTETEKFCLIYPYMRNGTLFDRLQCVGDTAP------------LPWHIRIGILIGISKA 277
+ CL+ + R G L +R + AP +P H+ + + I++
Sbjct: 189 VCLQQPHLCLVLEFARGGAL-NRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARG 247
Query: 278 IHYLHNVQPCSVICGSISSANILLDDQFQP--------KLTDFAMAHFRSHLEHQSCTIN 329
+ YLH ++ + S+NILL ++ + K+TDF +A E T
Sbjct: 248 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-----EWHRTT-- 300
Query: 330 MTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
S++ + W P E I+ S +D++S+G+++ E+LTG
Sbjct: 301 KMSTAGTYAWMAP-EVIKSSLFSKGSDIWSYGVLLWELLTG 340
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 78.2 bits (191), Expect = 2e-14
Identities = 83/308 (26%), Positives = 123/308 (39%), Gaps = 46/308 (14%)
Query: 170 LIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAA 229
+IG G +VYR + AVK +Q+ + E + + HPNI+ L A
Sbjct: 122 VIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKA 181
Query: 230 YFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSV 289
E CL+ Y G L L +P H+ + + I++ +HYLH V
Sbjct: 182 VCLEEPNLCLVMEYAAGGPLSRALA----GRRVPPHVLVNWAVQIARGMHYLHCEALVPV 237
Query: 290 ICGSISSANILL------DDQFQP--KLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYM 341
I + S NILL DD K+TDF +A E T S++ + W
Sbjct: 238 IHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR-----EWHKTT--QMSAAGTYAWMA 290
Query: 342 PEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLS 401
P E I+ S +DV+SFG+++ E+LTG + RG+D CL+
Sbjct: 291 P-EVIKASTFSKGSDVWSFGVLLWELLTG-------------------EVPYRGID-CLA 329
Query: 402 F-----LDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDP 456
++K P P L C A RP +L LE+ +A + E P
Sbjct: 330 VAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQV-LREMP 388
Query: 457 PTSLKSFR 464
S S +
Sbjct: 389 RDSFHSMQ 396
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 77.4 bits (189), Expect = 3e-14
Identities = 49/165 (29%), Positives = 83/165 (50%), Gaps = 3/165 (1%)
Query: 207 KRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI 266
K L E E+L IL + E E ++ YM NG+L + L + + W +
Sbjct: 61 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL 120
Query: 267 RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSC 326
R IL I+ ++YLHN+ P ++ + + NILLD++F K+ DF ++ +R QS
Sbjct: 121 RFRILHEIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSR 179
Query: 327 TINMTSSSSKHLWYMPEEYI--RQGKLSIKTDVYSFGIVIMEVLT 369
+ ++ PE Y ++ + SIK D+YS+ ++ EVL+
Sbjct: 180 SSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLS 224
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 76.3 bits (186), Expect = 8e-14
Identities = 90/344 (26%), Positives = 152/344 (44%), Gaps = 54/344 (15%)
Query: 154 SFQNIIEGTRNFHKDF---------LIGEGEIFEVY--RVEIQNLTYAVKLFKQEKKMQC 202
++++ E R F K+ +IG GE EVY R+++ K K
Sbjct: 599 TYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYS 658
Query: 203 KKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRL-QCVGDTAP 261
+K + FLSE ++ F HPNI+ L T++ +I +M NG L L Q G
Sbjct: 659 EKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTV 718
Query: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321
+ +G+L GI+ + YL + + + +++ NIL++ K++DF ++ + L
Sbjct: 719 IQ---LVGMLRGIAAGMKYLAEM---NYVHRDLAARNILVNSNLVCKVSDFGLSRY---L 769
Query: 322 EHQSCTINMTSSSSKHL---WYMPEEYIRQGKLSIKTDVYSFGIVIMEVLT-GCRVVLDD 377
+ + TSS + W PE I K + +DV+S+GIV+ EV++ G R D
Sbjct: 770 QDDTSDPTYTSSLGGKIPVRWTAPEA-IAYRKFTSASDVWSYGIVMWEVMSFGERPYWD- 827
Query: 378 PKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMD 437
+ +D++ + + D ++PP P + A L L C RP
Sbjct: 828 ---MSNQDVINAIEQ-----------DYRLPP-PMDCPAALHQLMLDCWQKDRNSRPRFA 872
Query: 438 EVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVED 481
E++NTL+ + P SLK+ + VPS P+ D
Sbjct: 873 EIVNTLDKMIRN-------PASLKTVAT-----ITAVPSQPLLD 904
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 73.6 bits (179), Expect = 5e-13
Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 20/209 (9%)
Query: 170 LIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAA 229
+IG G +VYR + AVK + + + ++ E + HPNI+ L
Sbjct: 103 IIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRG 162
Query: 230 YFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSV 289
CL+ Y R G L L +P H+ + + +++ ++YLHN P +
Sbjct: 163 ACLNPPHLCLVMEYARGGALSRVLA----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPI 218
Query: 290 ICGSISSANILLDDQFQP--------KLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYM 341
I + S NIL+ + + K+TDF +A E T S++ + W
Sbjct: 219 IHRDLKSINILILEAIENHNLADTVLKITDFGLAR-----EWHKTT--KMSAAGTYAWMA 271
Query: 342 PEEYIRQGKLSIKTDVYSFGIVIMEVLTG 370
P E IR S +DV+SFG+++ E+LTG
Sbjct: 272 P-EVIRLSLFSKSSDVWSFGVLLWELLTG 299
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 71.6 bits (174), Expect = 2e-12
Identities = 83/316 (26%), Positives = 134/316 (42%), Gaps = 33/316 (10%)
Query: 168 DFLIGEGEIFEVYRVEIQNLTYAVKL--FKQEKKMQCKKHWKRFLSELEVLLLFHHPNIL 225
D +IGEGE EVYR ++ + K K K W FL E ++ F HP+IL
Sbjct: 627 DTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHIL 686
Query: 226 ELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQ 285
L T+ + +I +M NG L D + +P + + +L GI+ ++YL N
Sbjct: 687 HLEGVVTKRKPIMIITEFMENGAL-DAFLREREDQLVPGQL-VAMLQGIASGMNYLSN-- 742
Query: 286 PCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEY 345
+ + +++ NIL++ K++DF + L+ T W PE
Sbjct: 743 -HNYVHRDLAARNILVNQNLCCKVSDFGLTRL---LDDFDGTYETQGGKIPIRWTAPEA- 797
Query: 346 IRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDK 405
I + +DV+SFGIV+ EVL+ D + ++ + +E+M+ S D
Sbjct: 798 IAHRIFTTASDVWSFGIVMWEVLS-----FGDKPYGEMSN--QEVMK--------SIEDG 842
Query: 406 KVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRC 465
P P + A L+ L C A RP ++ LE A+ P SL++
Sbjct: 843 YRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLAN-------PHSLRTIAN 895
Query: 466 PSPLFLENVPSIPVED 481
P +PS+ D
Sbjct: 896 FDPRMTLRLPSLSGSD 911
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/265 (26%), Positives = 114/265 (43%), Gaps = 36/265 (13%)
Query: 198 KKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVG 257
K+++ + K F+ EL L +HPNI++L Y CL+ Y G+L++ L
Sbjct: 63 KQIESESERKAFIVELRQLSRVNHPNIVKL--YGACLNPVCLVMEYAEGGSLYNVLH--- 117
Query: 258 DTAPLPWHIRIGIL---IGISKAIHYLHNVQPCSVICGSISSANILL-DDQFQPKLTDFA 313
PLP++ + + S+ + YLH++QP ++I + N+LL K+ DF
Sbjct: 118 GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG 177
Query: 314 MAHFRSHLEHQSCTI--NMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A C I +MT++ W PE + S K DV+S+GI++ EV+T
Sbjct: 178 TA----------CDIQTHMTNNKGSAAWMAPEVF-EGSNYSEKCDVFSWGIILWEVITR- 225
Query: 372 RVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAK 431
R D+ R + R PP +N + L RC +
Sbjct: 226 RKPFDEIGGPAFRIMWAVHNGTR-------------PPLIKNLPKPIESLMTRCWSKDPS 272
Query: 432 LRPSMDEVLNTLESTQASLYFAEDP 456
RPSM+E++ + A++P
Sbjct: 273 QRPSMEEIVKIMTHLMRYFPGADEP 297
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/265 (26%), Positives = 114/265 (43%), Gaps = 36/265 (13%)
Query: 198 KKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVG 257
K+++ + K F+ EL L +HPNI++L Y CL+ Y G+L++ L
Sbjct: 63 KQIESESERKAFIVELRQLSRVNHPNIVKL--YGACLNPVCLVMEYAEGGSLYNVLH--- 117
Query: 258 DTAPLPWHIRIGIL---IGISKAIHYLHNVQPCSVICGSISSANILL-DDQFQPKLTDFA 313
PLP++ + + S+ + YLH++QP ++I + N+LL K+ DF
Sbjct: 118 GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG 177
Query: 314 MAHFRSHLEHQSCTI--NMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A C I +MT++ W PE + S K DV+S+GI++ EV+T
Sbjct: 178 TA----------CDIQTHMTNNKGSAAWMAPEVF-EGSNYSEKCDVFSWGIILWEVITR- 225
Query: 372 RVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAK 431
R D+ R + R PP +N + L RC +
Sbjct: 226 RKPFDEIGGPAFRIMWAVHNGTR-------------PPLIKNLPKPIESLMTRCWSKDPS 272
Query: 432 LRPSMDEVLNTLESTQASLYFAEDP 456
RPSM+E++ + A++P
Sbjct: 273 QRPSMEEIVKIMTHLMRYFPGADEP 297
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/265 (26%), Positives = 114/265 (43%), Gaps = 36/265 (13%)
Query: 198 KKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVG 257
K+++ + K F+ EL L +HPNI++L Y CL+ Y G+L++ L
Sbjct: 63 KQIESESERKAFIVELRQLSRVNHPNIVKL--YGACLNPVCLVMEYAEGGSLYNVLH--- 117
Query: 258 DTAPLPWHIRIGIL---IGISKAIHYLHNVQPCSVICGSISSANILL-DDQFQPKLTDFA 313
PLP++ + + S+ + YLH++QP ++I + N+LL K+ DF
Sbjct: 118 GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG 177
Query: 314 MAHFRSHLEHQSCTI--NMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A C I +MT++ W PE + S K DV+S+GI++ EV+T
Sbjct: 178 TA----------CDIQTHMTNNKGSAAWMAPEVF-EGSNYSEKCDVFSWGIILWEVITR- 225
Query: 372 RVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAK 431
R D+ R + R PP +N + L RC +
Sbjct: 226 RKPFDEIGGPAFRIMWAVHNGTR-------------PPLIKNLPKPIESLMTRCWSKDPS 272
Query: 432 LRPSMDEVLNTLESTQASLYFAEDP 456
RPSM+E++ + A++P
Sbjct: 273 QRPSMEEIVKIMTHLMRYFPGADEP 297
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/265 (26%), Positives = 114/265 (43%), Gaps = 36/265 (13%)
Query: 198 KKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVG 257
K+++ + K F+ EL L +HPNI++L Y CL+ Y G+L++ L
Sbjct: 63 KQIESESERKAFIVELRQLSRVNHPNIVKL--YGACLNPVCLVMEYAEGGSLYNVLH--- 117
Query: 258 DTAPLPWHIRIGIL---IGISKAIHYLHNVQPCSVICGSISSANILL-DDQFQPKLTDFA 313
PLP++ + + S+ + YLH++QP ++I + N+LL K+ DF
Sbjct: 118 GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG 177
Query: 314 MAHFRSHLEHQSCTI--NMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGC 371
A C I +MT++ W PE + S K DV+S+GI++ EV+T
Sbjct: 178 TA----------CDIQTHMTNNKGSAAWMAPEVF-EGSNYSEKCDVFSWGIILWEVITR- 225
Query: 372 RVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAK 431
R D+ R + R PP +N + L RC +
Sbjct: 226 RKPFDEIGGPAFRIMWAVHNGTR-------------PPLIKNLPKPIESLMTRCWSKDPS 272
Query: 432 LRPSMDEVLNTLESTQASLYFAEDP 456
RPSM+E++ + A++P
Sbjct: 273 QRPSMEEIVKIMTHLMRYFPGADEP 297
>gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo
sapiens]
Length = 471
Score = 70.5 bits (171), Expect = 4e-12
Identities = 66/281 (23%), Positives = 126/281 (44%), Gaps = 25/281 (8%)
Query: 170 LIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAA 229
L+ E E+ +Y+ E A+K+FK+ + + F E++ + F PNIL +
Sbjct: 208 LLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFG 267
Query: 230 YFTETE----KFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQ 285
+ +F ++ Y GTL + L D L R+ +++G ++ ++ LH+ +
Sbjct: 268 ICIDETVTPPQFSIVMEYCELGTLRELLDREKD---LTLGKRMVLVLGAARGLYRLHHSE 324
Query: 286 PCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEY 345
+ G I S+N L+ +Q KL F + ++ + T T + P+E
Sbjct: 325 -APELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS-LGTTREKTDRVKSTAYLSPQEL 382
Query: 346 IRQG-KLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLD 404
+ +K+++YSFGIV+ E+ TG D P + +R+L+ +
Sbjct: 383 EDVFYQYDVKSEIYSFGIVLWEIATG-----DIPFQGCNSEKIRKLVA----------VK 427
Query: 405 KKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 445
++ P + ++L + C A +RPS+DE+L L +
Sbjct: 428 RQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST 468
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 70.1 bits (170), Expect = 5e-12
Identities = 77/307 (25%), Positives = 140/307 (45%), Gaps = 42/307 (13%)
Query: 154 SFQNIIEGTRNFHKDF---------LIGEGEIFEVY--RVEIQNLTYAVKLFKQEKKMQC 202
++++ E R F K+ +IG GE EV +++ K K
Sbjct: 601 TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT 660
Query: 203 KKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRL-QCVGDTAP 261
+K + FLSE ++ F HPN++ L T++ +I +M NG+L L Q G
Sbjct: 661 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV 720
Query: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321
+ +G+L GI+ + YL ++ + + +++ NIL++ K++DF ++ F L
Sbjct: 721 IQ---LVGMLRGIAAGMKYLADM---NYVHRDLAARNILVNSNLVCKVSDFGLSRF---L 771
Query: 322 EHQSCTINMTSSSSKHL---WYMPEEYIRQGKLSIKTDVYSFGIVIMEVLT-GCRVVLDD 377
E + TS+ + W PE I+ K + +DV+S+GIV+ EV++ G R D
Sbjct: 772 EDDTSDPTYTSALGGKIPIRWTAPEA-IQYRKFTSASDVWSYGIVMWEVMSYGERPYWD- 829
Query: 378 PKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMD 437
+ +D++ + + D ++PP P + + L L C RP
Sbjct: 830 ---MTNQDVINAIEQ-----------DYRLPP-PMDCPSALHQLMLDCWQKDRNHRPKFG 874
Query: 438 EVLNTLE 444
+++NTL+
Sbjct: 875 QIVNTLD 881
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 70.1 bits (170), Expect = 5e-12
Identities = 77/307 (25%), Positives = 140/307 (45%), Gaps = 42/307 (13%)
Query: 154 SFQNIIEGTRNFHKDF---------LIGEGEIFEVY--RVEIQNLTYAVKLFKQEKKMQC 202
++++ E R F K+ +IG GE EV +++ K K
Sbjct: 602 TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT 661
Query: 203 KKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRL-QCVGDTAP 261
+K + FLSE ++ F HPN++ L T++ +I +M NG+L L Q G
Sbjct: 662 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV 721
Query: 262 LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHL 321
+ +G+L GI+ + YL ++ + + +++ NIL++ K++DF ++ F L
Sbjct: 722 IQ---LVGMLRGIAAGMKYLADM---NYVHRDLAARNILVNSNLVCKVSDFGLSRF---L 772
Query: 322 EHQSCTINMTSSSSKHL---WYMPEEYIRQGKLSIKTDVYSFGIVIMEVLT-GCRVVLDD 377
E + TS+ + W PE I+ K + +DV+S+GIV+ EV++ G R D
Sbjct: 773 EDDTSDPTYTSALGGKIPIRWTAPEA-IQYRKFTSASDVWSYGIVMWEVMSYGERPYWD- 830
Query: 378 PKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMD 437
+ +D++ + + D ++PP P + + L L C RP
Sbjct: 831 ---MTNQDVINAIEQ-----------DYRLPP-PMDCPSALHQLMLDCWQKDRNHRPKFG 875
Query: 438 EVLNTLE 444
+++NTL+
Sbjct: 876 QIVNTLD 882
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 69.3 bits (168), Expect = 9e-12
Identities = 70/286 (24%), Positives = 127/286 (44%), Gaps = 34/286 (11%)
Query: 174 GEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTE 233
G+ +V E + +L + +++ Q + FL E++V+ HPN+L+ +
Sbjct: 351 GQAIKVTHRETGEVMVMKELIRFDEETQ-----RTFLKEVKVMRCLEHPNVLKFIGVLYK 405
Query: 234 TEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGS 293
++ I Y++ GTL ++ + + PW R+ I+ + YLH++ ++I
Sbjct: 406 DKRLNFITEYIKGGTLRGIIKSM--DSQYPWSQRVSFAKDIASGMAYLHSM---NIIHRD 460
Query: 294 ISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSK--------HLWYMPEEY 345
++S N L+ + + DF +A + Q + + + ++M E
Sbjct: 461 LNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEM 520
Query: 346 IRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDK 405
I K DV+SFGIV+ E++ RV D D L M+ GL + FLD+
Sbjct: 521 INGRSYDEKVDVFSFGIVLCEIIG--RVNADP-------DYLPRTMD-FGL-NVRGFLDR 569
Query: 406 KVPP-CPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASL 450
PP CP +F F + RC + RPS ++ + LE+ + L
Sbjct: 570 YCPPNCPPSF----FPITVRCCDLDPEKRPSFVKLEHWLETLRMHL 611
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 68.9 bits (167), Expect = 1e-11
Identities = 71/279 (25%), Positives = 127/279 (45%), Gaps = 39/279 (13%)
Query: 192 KLFKQEKKMQCKKHW-KRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLF 250
K+ ++ ++C + K FL+E++V+ HPN+L+ + +K L+ Y+ GTL
Sbjct: 334 KVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLK 393
Query: 251 DRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLT 310
D L+ + P PW ++ GI+ + YLH++ +I ++S N L+ +
Sbjct: 394 DFLRSMD---PFPWQQKVRFAKGIASGMAYLHSM---CIIHRDLNSHNCLIKLDKTVVVA 447
Query: 311 DFAMAHF------RSHLEHQSC---TINMTSSSSKHL-----WYMPEEYIRQGKLSIKTD 356
DF ++ R+ +E + T+ ++ ++M E + D
Sbjct: 448 DFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVD 507
Query: 357 VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVP-PCPRNFS 415
++SFGIV+ E++ V DP D L ++ GL+ L F +K VP CP F
Sbjct: 508 IFSFGIVLCEII---GQVYADP------DCLPRTLD-FGLNVKL-FWEKFVPTDCPPAF- 555
Query: 416 AKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAE 454
F LA C + RP+ ++ ++ E+ SLY E
Sbjct: 556 ---FPLAAICCRLEPESRPAFSKLEDSFEA--LSLYLGE 589
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,165,339
Number of Sequences: 37866
Number of extensions: 1107828
Number of successful extensions: 3711
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 426
Number of HSP's that attempted gapping in prelim test: 2981
Number of HSP's gapped (non-prelim): 700
length of query: 596
length of database: 18,247,518
effective HSP length: 108
effective length of query: 488
effective length of database: 14,157,990
effective search space: 6909099120
effective search space used: 6909099120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.