Search of human proteins with 215820660

Search of human proteins with 215820660

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
         (646 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s...  1290   0.0  
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa...  1290   0.0  
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7...   922   0.0  
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6...   922   0.0  
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5...   922   0.0  
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3...   922   0.0  
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2...   922   0.0  
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4...   914   0.0  
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s...   263   5e-70
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap...   212   8e-55
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap...   210   3e-54
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13...    89   2e-17
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s...    87   6e-17
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor...    87   6e-17
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor...    87   6e-17
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo...    83   9e-16
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa...    82   2e-15
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ...    80   8e-15
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ...    80   8e-15
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s...    79   1e-14
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform...    78   3e-14
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform...    78   3e-14
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s...    77   5e-14
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ...    73   9e-13
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s...    73   9e-13
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap...    71   3e-12
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...    70   5e-12
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...    70   5e-12
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...    70   5e-12
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...    69   1e-11

>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score = 1290 bits (3339), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD 60
           MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD
Sbjct: 1   MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD 60

Query: 61  IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE 120
           IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE
Sbjct: 61  IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE 120

Query: 121 SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL 180
           SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL
Sbjct: 121 SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL 180

Query: 181 VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV 240
           VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV
Sbjct: 181 VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV 240

Query: 241 SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP 300
           SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP
Sbjct: 241 SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP 300

Query: 301 TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP 360
           TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP
Sbjct: 301 TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP 360

Query: 361 IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV 420
           IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV
Sbjct: 361 IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV 420

Query: 421 FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV 480
           FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV
Sbjct: 421 FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV 480

Query: 481 VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV 540
           VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV
Sbjct: 481 VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV 540

Query: 541 TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR 600
           TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR
Sbjct: 541 TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR 600

Query: 601 EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER 646
           EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
Sbjct: 601 EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER 646


>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score = 1290 bits (3339), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD 60
           MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD
Sbjct: 1   MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD 60

Query: 61  IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE 120
           IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE
Sbjct: 61  IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE 120

Query: 121 SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL 180
           SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL
Sbjct: 121 SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL 180

Query: 181 VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV 240
           VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV
Sbjct: 181 VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV 240

Query: 241 SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP 300
           SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP
Sbjct: 241 SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP 300

Query: 301 TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP 360
           TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP
Sbjct: 301 TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP 360

Query: 361 IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV 420
           IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV
Sbjct: 361 IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV 420

Query: 421 FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV 480
           FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV
Sbjct: 421 FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV 480

Query: 481 VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV 540
           VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV
Sbjct: 481 VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV 540

Query: 541 TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR 600
           TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR
Sbjct: 541 TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR 600

Query: 601 EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER 646
           EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
Sbjct: 601 EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER 646


>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
           [Homo sapiens]
          Length = 663

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 39  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 98

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 99  KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 158

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 159 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 218

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 219 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 278

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 279 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 338

Query: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 339 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 398

Query: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 399 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 458

Query: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 459 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 518

Query: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 519 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 578

Query: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 579 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 638

Query: 622 VLGIFFLALRLLAYLVLRYRVKSER 646
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 639 VLGIFFISLRLIAYFVLRYKIRAER 663


>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
           [Homo sapiens]
          Length = 644

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 20  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 79

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 80  KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 139

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 140 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 199

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 200 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 259

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 260 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 319

Query: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 320 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 379

Query: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 380 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 439

Query: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 440 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 499

Query: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 500 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 559

Query: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 560 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 619

Query: 622 VLGIFFLALRLLAYLVLRYRVKSER 646
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 620 VLGIFFISLRLIAYFVLRYKIRAER 644


>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
           [Homo sapiens]
          Length = 668

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 44  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 103

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 104 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 163

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 164 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 223

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 224 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 283

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 284 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 343

Query: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 344 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 403

Query: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 404 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 463

Query: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 464 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 523

Query: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 524 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 583

Query: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 584 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 643

Query: 622 VLGIFFLALRLLAYLVLRYRVKSER 646
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 644 VLGIFFISLRLIAYFVLRYKIRAER 668


>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
           [Homo sapiens]
          Length = 677

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 53  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 112

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 113 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 172

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 173 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 232

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 233 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 292

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 293 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 352

Query: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 353 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 412

Query: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 413 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 472

Query: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 473 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 532

Query: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 533 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 592

Query: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 593 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 652

Query: 622 VLGIFFLALRLLAYLVLRYRVKSER 646
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 653 VLGIFFISLRLIAYFVLRYKIRAER 677


>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
           [Homo sapiens]
          Length = 666

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 42  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 101

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 102 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 161

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 162 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 221

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 222 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 281

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 282 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 341

Query: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 342 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 401

Query: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 402 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 461

Query: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 462 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 521

Query: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 522 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 581

Query: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 582 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 641

Query: 622 VLGIFFLALRLLAYLVLRYRVKSER 646
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 642 VLGIFFISLRLIAYFVLRYKIRAER 666


>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
           [Homo sapiens]
          Length = 678

 Score =  914 bits (2363), Expect = 0.0
 Identities = 459/637 (72%), Positives = 537/637 (84%), Gaps = 16/637 (2%)

Query: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 42  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 101

Query: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 102 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 161

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 162 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 221

Query: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 222 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 281

Query: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 282 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 341

Query: 326 RAVQNGLCAMAEKKSSPEKNEV-PAPCPPCPPEVDPIE--------------SHTFATST 370
           RAV+ G+C    K+      EV P        EV   +               H+F+ S 
Sbjct: 342 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASC 401

Query: 371 LTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFS 430
           LTQFCILFKRTFLSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFS
Sbjct: 402 LTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFS 461

Query: 431 MLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIV 490
           MLFLMFAALMPTVLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIV
Sbjct: 462 MLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIV 521

Query: 491 YWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSG 550
           YWMT QP++  RF+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSG
Sbjct: 522 YWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSG 581

Query: 551 FFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRAL 609
           FFVSF TIPTYLQW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR L
Sbjct: 582 FFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILREL 641

Query: 610 DVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER 646
           DVE+AKLY+DF+VLGIFF++LRL+AY VLRY++++ER
Sbjct: 642 DVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 678


>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
           sapiens]
          Length = 655

 Score =  263 bits (671), Expect = 5e-70
 Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%)

Query: 74  PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132
           PC RK   K +L  ++G   +  L  I+GP+G GKS+ +++LA  ++ SG+ G +L+NG 
Sbjct: 54  PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111

Query: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190
           PR    F+  S Y++QDD+++  LTV E +  SA L+L+       K E +  ++  LGL
Sbjct: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170

Query: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245
              + ++        +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K 
Sbjct: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230

Query: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305
           +++ GRTII +IHQP   +F++FD L +L+ G+ +F G     + Y +  G HC  Y+NP
Sbjct: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290

Query: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345
           ADF +++ +G+   +                     P++ +  +  + +   K++  E +
Sbjct: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350

Query: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405
           ++         ++   +  ++ TS   Q   + KR+F ++L +   +  + +  VV+G++
Sbjct: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408

Query: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465
           IG +Y  + +D++ + N  G LFF      F+++    L F +E  +F+ E+++ +Y + 
Sbjct: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467

Query: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524
           +Y+L K ++D +P +++  +++  IVY+M G   +   F +        A  A S+ L I
Sbjct: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527

Query: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583
            A  + + VAT +  +  + +++FSG  V+  TI ++L W  Y S  RYGF  +    + 
Sbjct: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587

Query: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636
                 G+   G+  C    C   E   + + +D+    L+ + + L    +    +AYL
Sbjct: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646

Query: 637 VLRYRVK 643
            L +  K
Sbjct: 647 KLLFLKK 653


>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
           sapiens]
          Length = 651

 Score =  212 bits (540), Expect = 8e-55
 Identities = 170/626 (27%), Positives = 296/626 (47%), Gaps = 51/626 (8%)

Query: 54  PKRSAVDIEFVELSYSVREGPCW-----RKRGYKTLLKCLSGKFCRRELIGIMGPSGAGK 108
           P+  ++ I     S S R  P W     R++  + +LK +S      +++ I+G SG+GK
Sbjct: 33  PEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGK 92

Query: 109 STFMNILAGY--RESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSA 166
           +T ++ ++G   R     G++ VNGR      F+    Y++Q D LL  LTV E +  +A
Sbjct: 93  TTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTA 152

Query: 167 NLKLSEKQEVKKELVTEILTALGLMSCSHTRTALL--------SGGQRKRLAIALELVNN 218
            L +        +   E + A   +S SH    L+        S G+R+R++IA +L+ +
Sbjct: 153 LLAIRRGNPGSFQKKVEAVMAE--LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQD 210

Query: 219 PPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQ 278
           P VM FDEPT+GLD  +  Q+V L+  LA+  R ++ TIHQP ++LF++FDK+ ILS G+
Sbjct: 211 PKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGE 270

Query: 279 CIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASG---------EYGDLNPMLFRAV- 328
            IF G    ++ +    G  CP + NP DF +++ S          E      M+  A  
Sbjct: 271 LIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYK 330

Query: 329 QNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRD 388
           ++ +C    K     K+    P  P   +  P           ++  +L +R   +++R+
Sbjct: 331 KSAICHKTLKNIERMKHLKTLPMVPFKTKDSP--------GVFSKLGVLLRRVTRNLVRN 382

Query: 389 TVLTHLRFMSHVVIGVLIGLLYLHIGDDASK--VFNNTGCLFFSMLFLMFAALMPTVLTF 446
            +    R + ++++G+ +    L +  +  K  + +  G L+  +    +  ++  V  F
Sbjct: 383 KLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLF 442

Query: 447 PLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLF 506
           P+  AV  +E  +  Y      LA  +  +PF VV  +++ S+ YW  G   E +RF  F
Sbjct: 443 PVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYF 502

Query: 507 SALATATALVAQSLGL-LIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWS 565
           SA   A  L+ + L L L+G   N   V + V  ++   VL+ SGF  + + +P   +  
Sbjct: 503 SAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKII 562

Query: 566 SYLSYVRYGFEGVILT-IYGMERGDLTC--------LEERCPFREP-QSILRALDVEDAK 615
           SY ++ +Y  E +++   YG+   + TC            C F +  Q I +      ++
Sbjct: 563 SYFTFQKYCSEILVVNEFYGL---NFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSR 619

Query: 616 LYMDFLVLGIFFLALRLLAYLVLRYR 641
             M+FL+L  F  AL +L  +V + R
Sbjct: 620 FTMNFLILYSFIPALVILGIVVFKIR 645


>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
           sapiens]
          Length = 673

 Score =  210 bits (535), Expect = 3e-54
 Identities = 149/582 (25%), Positives = 262/582 (45%), Gaps = 37/582 (6%)

Query: 88  LSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGM--KGQILVNGRPRELRTFRKMSCY 145
           LS K    +++ I+G SG G+++ ++++ G    G    GQI +NG+P   +  RK   +
Sbjct: 91  LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAH 150

Query: 146 IMQDDMLLPHLTVLEAMMVSANLKLSE--KQEVKKELVTEILTALGLMSCSHTRTAL--- 200
           + Q + LLP+LTV E +   A ++L     Q  + + V +++  L L  C+ TR      
Sbjct: 151 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYV 210

Query: 201 --LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
             LSGG+R+R++I ++L+ NP ++  DEPTSGLDS +   +V  +  LA+G R ++ ++H
Sbjct: 211 RGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH 270

Query: 259 QPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYG 318
           QP + +F +FD + +++ G  I+ G   +++ Y   +G  CP Y NPADF +++ S +  
Sbjct: 271 QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR 330

Query: 319 DLNPML-FRAVQNGLCAM--------------AEKKSSPEKNEVPAPCPPCPPEVDPIES 363
                L  R     L A+              AE K   E   V +   P   + + + S
Sbjct: 331 SREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPL--DTNCLPS 388

Query: 364 HTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNN 423
            T     + QF  L +R   +  RD     +      ++ + IG LY   G       + 
Sbjct: 389 PTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDT 448

Query: 424 TGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483
              LF     + F  ++  +     E A+   E  +  Y+   Y+ AK + ++P      
Sbjct: 449 AALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYI 508

Query: 484 VVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAI 543
           ++Y    YW+         FLL   L        + + L   A   +  +A+F       
Sbjct: 509 IIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYN 568

Query: 544 PVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVI-----LTIYGMERGDLTCLEERCP 598
              L  GF ++  ++ T   W S +S++R+ FEG++        Y M  G+LT       
Sbjct: 569 SFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAV---- 624

Query: 599 FREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRY 640
                 IL  ++++   LY  +L++        +L Y+ LR+
Sbjct: 625 --SGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRF 664


>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
            [Homo sapiens]
          Length = 5058

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 63/204 (30%), Positives = 109/204 (53%), Gaps = 10/204 (4%)

Query: 80   GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGR--PRELR 137
            G+K +++ LS  F R ++  ++G +GAGK+T +++L G       G I++NG+    +L 
Sbjct: 3853 GHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDLS 3911

Query: 138  TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL---VTEILTALGLMSCS 194
              R       Q D+LL +LTV E +++ A++K    Q  KKEL   V + L  + L    
Sbjct: 3912 RVRMELGVCPQQDILLDNLTVREHLLLFASIKAP--QWTKKELHQQVNQTLQDVDLTQHQ 3969

Query: 195  HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
            H +T  LSGG +++L++ +  +     +  DEPTSG+D  S   +  ++    + GRTII
Sbjct: 3970 HKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTII 4028

Query: 255  CTIHQPSAKLFEMFDKLYILSQGQ 278
             T H    +   + D++ +L  G+
Sbjct: 4029 FTTHHLD-EAEALSDRVAVLQHGR 4051



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 48/166 (28%), Positives = 82/166 (49%), Gaps = 9/166 (5%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN---GRPRELR---TFRKMSCYIMQD 149
            E  G++G +GAGKST   +L G   S   G  ++    G   +L    T   +  Y  Q 
Sbjct: 4748 ECFGLLGVNGAGKSTTFKMLNG-EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQ 4806

Query: 150  DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
            D L   LT  E +    +L+   +Q +  E+  +++  L L + +    A  SGG +++L
Sbjct: 4807 DALDELLTGWEHLYYYCSLRGIPRQCIP-EVAGDLIRRLHLEAHADKPVATYSGGTKRKL 4865

Query: 210  AIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKSLAQGGRTII 254
            + AL LV  P ++  DEP+SG+D  S  +   ++MK + +G   ++
Sbjct: 4866 STALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911


>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
            sapiens]
          Length = 2273

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 62/194 (31%), Positives = 98/194 (50%), Gaps = 6/194 (3%)

Query: 92   FCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE--LRTFRKMSCYIMQD 149
            F   ++   +G +GAGK+T ++IL G       G +LV GR  E  L   R+      Q 
Sbjct: 953  FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011

Query: 150  DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
            ++L  HLTV E M+  A LK   ++E + E+   +L   GL    +     LSGG +++L
Sbjct: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEA-MLEDTGLHHKRNEEAQDLSGGMQRKL 1070

Query: 210  AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFD 269
            ++A+  V +  V+  DEPTSG+D  S   +  L+     G   I+ T H   A L  + D
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128

Query: 270  KLYILSQGQCIFKG 283
            ++ I++QG+    G
Sbjct: 1129 RIAIIAQGRLYCSG 1142



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 45/165 (27%), Positives = 84/165 (50%), Gaps = 4/165 (2%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGK+T   +L G   +   G   V G+     +    +   Y  Q D + 
Sbjct: 1966 ECFGLLGVNGAGKTTTFKMLTG-DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024

Query: 154  PHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIAL 213
              LT  E + + A L+    +E++K +    + +LGL   +       SGG +++L+ A+
Sbjct: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083

Query: 214  ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
             L+  PP++  DEPT+G+D  +   + +++ S+ + GR ++ T H
Sbjct: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128


>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
            [Homo sapiens]
          Length = 2277

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 10/203 (4%)

Query: 80   GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELR 137
            G K  +  L+  F    +  ++GP+GAGK+T +++L G   +   G I V G+    +L 
Sbjct: 1038 GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA-GTIFVYGKDIKTDLH 1096

Query: 138  TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTAL---GLMSCS 194
            T RK     MQ D+L  +LT  E +++  ++K+      KK+L  E+   L   GL S  
Sbjct: 1097 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHR 1154

Query: 195  HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
            H R   LSGG +++L+I++ L+    V+  DEP++G+D  S   +  ++         I+
Sbjct: 1155 HKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIIL 1214

Query: 255  CTIHQPSAKLFEMFDKLYILSQG 277
             T H   A++  + D++  L QG
Sbjct: 1215 STHHLDEAEV--LSDRIAFLEQG 1235



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 5/166 (3%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSC---YIMQDDML 152
            E  G++G +GAGK+T   +L G       G IL+  +   L      S    Y  Q+D L
Sbjct: 1966 ECFGLLGVNGAGKTTIFKMLTGDIIPS-SGNILIRNKTGSLGHVDSHSSLVGYCPQEDAL 2024

Query: 153  LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
               +TV E +   A +    ++++K E V ++L  L LM      T++ S G +++L+ A
Sbjct: 2025 DDLVTVEEHLYFYARVHGIPEKDIK-ETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTA 2083

Query: 213  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
            L L+  P ++  DEP+SG+D  S   +  ++    Q   ++I T H
Sbjct: 2084 LALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2129


>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
            [Homo sapiens]
          Length = 2595

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 10/203 (4%)

Query: 80   GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELR 137
            G K  +  L+  F    +  ++GP+GAGK+T +++L G   +   G I V G+    +L 
Sbjct: 1356 GSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA-GTIFVYGKDIKTDLH 1414

Query: 138  TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTAL---GLMSCS 194
            T RK     MQ D+L  +LT  E +++  ++K+      KK+L  E+   L   GL S  
Sbjct: 1415 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHW--TKKQLHEEVKRTLKDTGLYSHR 1472

Query: 195  HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
            H R   LSGG +++L+I++ L+    V+  DEP++G+D  S   +  ++         I+
Sbjct: 1473 HKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIIL 1532

Query: 255  CTIHQPSAKLFEMFDKLYILSQG 277
             T H   A++  + D++  L QG
Sbjct: 1533 STHHLDEAEV--LSDRIAFLEQG 1553



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 5/166 (3%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSC---YIMQDDML 152
            E  G++G +GAGK+T   +L G       G IL+  +   L      S    Y  Q+D L
Sbjct: 2284 ECFGLLGVNGAGKTTIFKMLTGDIIPS-SGNILIRNKTGSLGHVDSHSSLVGYCPQEDAL 2342

Query: 153  LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
               +TV E +   A +    ++++K E V ++L  L LM      T++ S G +++L+ A
Sbjct: 2343 DDLVTVEEHLYFYARVHGIPEKDIK-ETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTA 2401

Query: 213  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
            L L+  P ++  DEP+SG+D  S   +  ++    Q   ++I T H
Sbjct: 2402 LALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447


>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
           sapiens]
          Length = 1543

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 65/213 (30%), Positives = 105/213 (49%), Gaps = 9/213 (4%)

Query: 96  ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPREL---RTFRKMSCYIMQDDML 152
           ++  I+G +GAGKST +NIL+G   S      + N +  E+      RK   +  Q +  
Sbjct: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480

Query: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LTV E + V A +K  + +EV++E V  I+  L + S        LSGGQ+++L + 
Sbjct: 481 FDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539

Query: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272
           + ++ +P V+  DEPT+GLD  S  +V SL+K        +  T     A +  + D+  
Sbjct: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADI--LADRKV 597

Query: 273 ILSQGQCIFKGVVTNLIPYLK-GLGLHCPTYHN 304
            LS G+   K   ++L    K G+G H   + N
Sbjct: 598 FLSNGK--LKCAGSSLFLKRKWGIGYHLSLHRN 628



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 61/248 (24%), Positives = 112/248 (45%), Gaps = 33/248 (13%)

Query: 19   AMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRK 78
            A A+T  +  E PV+T      E + T+   FS   K+ A+      +S+ V++G     
Sbjct: 1182 ANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIR----NVSFCVKKG----- 1232

Query: 79   RGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELR- 137
                             E++G++G +GAGKST + ++ G  +    G +++ G    +R 
Sbjct: 1233 -----------------EVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASVRQ 1274

Query: 138  ---TFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCS 194
                  K   Y  Q++ L P LT+ E + + A +K   K++     ++ ++ AL L    
Sbjct: 1275 QHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQEQL 1333

Query: 195  HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQG-GRTI 253
                  LS G +++L   L ++ NP V+  DEP +G+D     Q+  ++++  +   R  
Sbjct: 1334 KAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGT 1393

Query: 254  ICTIHQPS 261
            + T H  S
Sbjct: 1394 LLTTHYMS 1401


>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
            sapiens]
          Length = 2261

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/201 (30%), Positives = 103/201 (51%), Gaps = 5/201 (2%)

Query: 80   GYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAG-YRESGMKGQILVNGRPRELRT 138
            G K  +  L+  F   ++   +G +GAGK+T M+IL G +  +     IL      E+ T
Sbjct: 911  GMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMST 970

Query: 139  FRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCS-HTR 197
             R+      Q ++L   LTV E +   A LK   ++ VK E+  ++   +GL S    ++
Sbjct: 971  IRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEM-EQMALDVGLPSSKLKSK 1029

Query: 198  TALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTI 257
            T+ LSGG +++L++AL  V    V+  DEPT+G+D  S   +  L+    QG   I+ T 
Sbjct: 1030 TSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTH 1089

Query: 258  HQPSAKLFEMFDKLYILSQGQ 278
            H   A +  + D++ I+S G+
Sbjct: 1090 HMDEADV--LGDRIAIISHGK 1108



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 49/166 (29%), Positives = 83/166 (50%), Gaps = 6/166 (3%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGKS+   +L G   +  +G   +N       +    +   Y  Q D + 
Sbjct: 1940 ECFGLLGVNGAGKSSTFKMLTG-DTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998

Query: 154  PHLTVLEAMMVSANLKLSEKQEVKKELVTE-ILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LT  E +   A L+   ++EV K  V E  +  LGL+          SGG +++L+ A
Sbjct: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056

Query: 213  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
            + L+  PPV+F DEPT+G+D  +   + +   S+ + GR+++ T H
Sbjct: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102


>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 60/206 (29%), Positives = 101/206 (49%), Gaps = 7/206 (3%)

Query: 76  WRKRGYKT-LLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134
           +RK+G     L+ LS      ++  ++G SG GKST MNIL G          +   R  
Sbjct: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546

Query: 135 ELRTF---RKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLM 191
           E+      RKM     Q D+    LTV E + + A++K      + +E V ++L  L + 
Sbjct: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605

Query: 192 SCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGR 251
           +    +   LSGGQ+++L++ + ++ NP ++  DEPT+G+D  S   V +L+K       
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

Query: 252 TIICTIHQPSAKLFEMFDKLYILSQG 277
           T+  T     A +  + D+  ++SQG
Sbjct: 666 TVFSTHFMDEADI--LADRKAVISQG 689



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 58/203 (28%), Positives = 94/203 (46%), Gaps = 9/203 (4%)

Query: 92   FC--RRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRT---FRKMSCYI 146
            FC  + E++G++GP+GAGKST +NIL G  E    GQ+ +     E        K   Y 
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETSEDDDSLKCMGYC 1379

Query: 147  MQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQR 206
             Q + L P  T+ E   +   +K     ++K E+++ I  AL L          L  G +
Sbjct: 1380 PQINPLWPDTTLQEHFEIYGAVKGMSASDMK-EVISRITHALDLKEHLQKTVKKLPAGIK 1438

Query: 207  KRLAIALELVNNPPVMFFDEPTSGLD-SASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
            ++L  AL ++ NP +   DEP++G+D  A      ++  +     R  I T H    +  
Sbjct: 1439 RKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHY-MEEAE 1497

Query: 266  EMFDKLYILSQGQCIFKGVVTNL 288
             + D++ I+  GQ    G V +L
Sbjct: 1498 AVCDRVAIMVSGQLRCIGTVQHL 1520


>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 60/206 (29%), Positives = 101/206 (49%), Gaps = 7/206 (3%)

Query: 76  WRKRGYKT-LLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134
           +RK+G     L+ LS      ++  ++G SG GKST MNIL G          +   R  
Sbjct: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546

Query: 135 ELRTF---RKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLM 191
           E+      RKM     Q D+    LTV E + + A++K      + +E V ++L  L + 
Sbjct: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605

Query: 192 SCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGR 251
           +    +   LSGGQ+++L++ + ++ NP ++  DEPT+G+D  S   V +L+K       
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

Query: 252 TIICTIHQPSAKLFEMFDKLYILSQG 277
           T+  T     A +  + D+  ++SQG
Sbjct: 666 TVFSTHFMDEADI--LADRKAVISQG 689



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 58/203 (28%), Positives = 94/203 (46%), Gaps = 9/203 (4%)

Query: 92   FC--RRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRT---FRKMSCYI 146
            FC  + E++G++GP+GAGKST +NIL G  E    GQ+ +     E        K   Y 
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETSEDDDSLKCMGYC 1379

Query: 147  MQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQR 206
             Q + L P  T+ E   +   +K     ++K E+++ I  AL L          L  G +
Sbjct: 1380 PQINPLWPDTTLQEHFEIYGAVKGMSASDMK-EVISRITHALDLKEHLQKTVKKLPAGIK 1438

Query: 207  KRLAIALELVNNPPVMFFDEPTSGLD-SASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265
            ++L  AL ++ NP +   DEP++G+D  A      ++  +     R  I T H    +  
Sbjct: 1439 RKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHY-MEEAE 1497

Query: 266  EMFDKLYILSQGQCIFKGVVTNL 288
             + D++ I+  GQ    G V +L
Sbjct: 1498 AVCDRVAIMVSGQLRCIGTVQHL 1520


>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
           sapiens]
          Length = 1704

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 57/182 (31%), Positives = 102/182 (56%), Gaps = 8/182 (4%)

Query: 100 IMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLLPHLT 157
           ++G +GAGK+T +++L G       G+  ++G    +++   RK      Q D+L  +LT
Sbjct: 564 LLGHNGAGKTTTLSMLTGLFPP-TSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLT 622

Query: 158 VLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVN 217
           V E +   A LK   +Q+  +E V ++L  +GL    ++R+  LSGG R++L+I + L+ 
Sbjct: 623 VAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIA 681

Query: 218 NPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH-QPSAKLFEMFDKLYILSQ 276
              V+  DEPTSG+D+ S   +  L++   +  RTI+ T H    A L  + D++ I+++
Sbjct: 682 GSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADL--LGDRIAIMAK 738

Query: 277 GQ 278
           G+
Sbjct: 739 GE 740



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 53/185 (28%), Positives = 90/185 (48%), Gaps = 5/185 (2%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGR--PRELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGK+T   +L G  ES   G   V G     ++   R+   Y  Q D LL
Sbjct: 1410 ECFGLLGFNGAGKTTTFKMLTG-EESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALL 1468

Query: 154  PHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIAL 213
             H+T  E +++ A L+   ++ +    V   L  L L   ++      SGG +++L+  +
Sbjct: 1469 DHMTGREMLVMYARLRGIPERHIGA-CVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGI 1527

Query: 214  ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYI 273
             L+  P V+F DEP++G+D  +   +   +    + G+ II T H    +   +  +L I
Sbjct: 1528 ALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHS-MEECEALCTRLAI 1586

Query: 274  LSQGQ 278
            + QGQ
Sbjct: 1587 MVQGQ 1591


>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
            [Homo sapiens]
          Length = 2436

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 54/198 (27%), Positives = 99/198 (50%), Gaps = 4/198 (2%)

Query: 82   KTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAG-YRESGMKGQILVNGRPRELRTFR 140
            K  L  LS      +++  +G +GAGK+T M+IL G +  +     I  +    E+   R
Sbjct: 1005 KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIR 1064

Query: 141  KMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTAL 200
            K      Q ++L   LTV E +   + LK   ++E+++E+  +++  L L +  H+    
Sbjct: 1065 KNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREM-DKMIEDLELSNKRHSLVQT 1123

Query: 201  LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQP 260
            LSGG +++L++A+  V     +  DEPT+G+D  +   +  L+     G   ++ T H  
Sbjct: 1124 LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMD 1183

Query: 261  SAKLFEMFDKLYILSQGQ 278
             A L  + D++ I+S G+
Sbjct: 1184 EADL--LGDRIAIISHGK 1199



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 52/166 (31%), Positives = 86/166 (51%), Gaps = 6/166 (3%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGK++   +L G  ES   G+  VNG    +EL   ++   Y  Q D L 
Sbjct: 2082 ECFGLLGVNGAGKTSTFKMLTG-DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALF 2140

Query: 154  PHLTVLEAMMVSANLK-LSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LT  E + +   L+ +S K E +  +V   L  L L   +       SGG +++L+ A
Sbjct: 2141 DELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLSTA 2198

Query: 213  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
            + L+  P  +F DEPT+G+D  +   + +L+  L + GR+++ T H
Sbjct: 2199 IALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244


>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
            [Homo sapiens]
          Length = 2466

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 54/198 (27%), Positives = 99/198 (50%), Gaps = 4/198 (2%)

Query: 82   KTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAG-YRESGMKGQILVNGRPRELRTFR 140
            K  L  LS      +++  +G +GAGK+T M+IL G +  +     I  +    E+   R
Sbjct: 1035 KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIR 1094

Query: 141  KMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTAL 200
            K      Q ++L   LTV E +   + LK   ++E+++E+  +++  L L +  H+    
Sbjct: 1095 KNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREM-DKMIEDLELSNKRHSLVQT 1153

Query: 201  LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQP 260
            LSGG +++L++A+  V     +  DEPT+G+D  +   +  L+     G   ++ T H  
Sbjct: 1154 LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMD 1213

Query: 261  SAKLFEMFDKLYILSQGQ 278
             A L  + D++ I+S G+
Sbjct: 1214 EADL--LGDRIAIISHGK 1229



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 52/166 (31%), Positives = 86/166 (51%), Gaps = 6/166 (3%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGK++   +L G  ES   G+  VNG    +EL   ++   Y  Q D L 
Sbjct: 2112 ECFGLLGVNGAGKTSTFKMLTG-DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALF 2170

Query: 154  PHLTVLEAMMVSANLK-LSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LT  E + +   L+ +S K E +  +V   L  L L   +       SGG +++L+ A
Sbjct: 2171 DELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLSTA 2228

Query: 213  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
            + L+  P  +F DEPT+G+D  +   + +L+  L + GR+++ T H
Sbjct: 2229 IALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2274


>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
           sapiens]
          Length = 1617

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 65/230 (28%), Positives = 106/230 (46%), Gaps = 7/230 (3%)

Query: 78  KRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN---GRPR 134
           K G    LK L       ++  I+G SGAGKS+ +NIL G          + N      +
Sbjct: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQ 549

Query: 135 ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCS 194
           +L   RK++    Q ++    LTV E + + A +K    +EV++E V  IL  L + +  
Sbjct: 550 DLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNIQ 608

Query: 195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTII 254
                 LS GQ+++L   + ++ +P ++  DEPT+GLD  S  QV SL++        + 
Sbjct: 609 DNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILF 668

Query: 255 CTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHN 304
            T     A +  + D+  I+S G+    G  +  +    GLG H   + N
Sbjct: 669 STQSMDEADI--LADRKVIMSNGRLKCAG-SSMFLKRRWGLGYHLSLHRN 715



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 57/239 (23%), Positives = 118/239 (49%), Gaps = 8/239 (3%)

Query: 51   SHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKST 110
            S L ++  +    +   Y+ ++  C+ KR  K   + +S      E++G++GP+GAGKS+
Sbjct: 1269 SILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSS 1328

Query: 111  FMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL 170
             + +++G  +    G++ + G    L        Y  Q+++L P LT+ E + V A +K 
Sbjct: 1329 SIRMISGITKP-TAGEVELKGCSSVLGHLG----YCPQENVLWPMLTLREHLEVYAAVKG 1383

Query: 171  SEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSG 230
              K + +   +  +++A  L    +     L+ G  ++L   L L+ N PV+  DEP++G
Sbjct: 1384 LRKADARLA-IARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTG 1442

Query: 231  LDSASCFQVVSLMKSLAQG-GRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNL 288
            +D     Q+   ++++ +   R ++ T H   A+   + D++ I+  G+    G + +L
Sbjct: 1443 IDPTGQQQMWQAIQAVVKNTERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500


>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
            sapiens]
          Length = 2146

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 58/195 (29%), Positives = 98/195 (50%), Gaps = 4/195 (2%)

Query: 85   LKCLSGKFCRRELIGIMGPSGAGKSTFMNILAG-YRESGMKGQILVNGRPRELRTFRKMS 143
            L+ LS  F +  +   +G +GAGK+T ++IL+G +  SG    IL +     +   R   
Sbjct: 824  LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHL 883

Query: 144  CYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSG 203
                Q ++L   LTV E +     LK      V  E    +L  +GL+S    +T  LSG
Sbjct: 884  GVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQ-DRLLQDVGLVSKQSVQTRHLSG 942

Query: 204  GQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAK 263
            G +++L++A+  V    V+  DEPT+G+D AS   +  L+    +G   I+ T H   A+
Sbjct: 943  GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAE 1002

Query: 264  LFEMFDKLYILSQGQ 278
            L  + D++ +++ G+
Sbjct: 1003 L--LGDRVAVVAGGR 1015



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 47/165 (28%), Positives = 86/165 (52%), Gaps = 4/165 (2%)

Query: 96   ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
            E  G++G +GAGK++   ++ G   +  +G+ ++ G    RE         Y  Q D + 
Sbjct: 1821 ECFGLLGVNGAGKTSTFRMVTGDTLAS-RGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879

Query: 154  PHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIAL 213
              LT  E + + A L+   + +V +   +  L  LGL   +       SGG +++LA AL
Sbjct: 1880 ELLTGREHLELLARLRGVPEAQVAQTAGSG-LARLGLSWYADRPAGTYSGGNKRKLATAL 1938

Query: 214  ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
             LV +P V+F DEPT+G+D ++   + + + ++ + GR+++ T H
Sbjct: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983


>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
           sapiens]
          Length = 1624

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 45/152 (29%), Positives = 79/152 (51%), Gaps = 4/152 (2%)

Query: 96  ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN---GRPRELRTFRKMSCYIMQDDML 152
           ++  ++G SGAGK+T +NIL+G          + N    R  ++    K + +  Q ++ 
Sbjct: 511 QITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQ 570

Query: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LTV E + + A +K     EV+KE V  ++  L + +        LSGGQ ++L   
Sbjct: 571 FGFLTVKENLRLFAKIKGILPHEVEKE-VQRVVQELEMENIQDILAQNLSGGQNRKLTFG 629

Query: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 244
           + ++ +P V+  DEPT+GLD  S  ++ +L+K
Sbjct: 630 IAILGDPQVLLLDEPTAGLDPLSRHRIWNLLK 661



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 60/223 (26%), Positives = 112/223 (50%), Gaps = 8/223 (3%)

Query: 68   YSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQI 127
            Y+ ++  C+ KR  K   + +S    + E+IG++G +GAGKST + ++ G  +    GQ+
Sbjct: 1292 YAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKP-TAGQV 1350

Query: 128  LVNGRPR-ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILT 186
            ++ G    E   F     Y  Q++ L P+LTV + + V A +K   K +     +T ++ 
Sbjct: 1351 ILKGSGGGEPLGFLG---YCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIA-ITRLVD 1406

Query: 187  ALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSL 246
            AL L          LS G +++L   L ++ NP V+  DEP++G+D     Q+  ++++ 
Sbjct: 1407 ALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRAT 1466

Query: 247  AQG-GRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNL 288
             +   R  + T H   A+   + D++ I+  G+    G + +L
Sbjct: 1467 FRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1508


>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
          Length = 1581

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 61/224 (27%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 68   YSVREGPCWRKRGYKTLLKCLSGKFCRR--ELIGIMGPSGAGKSTFMNILAGYRESGMKG 125
            Y+ +   C+ KR  K   + +S  FC R  E++G++G +GAGKST + ++ G  +    G
Sbjct: 1249 YAGKRKGCFSKRKNKIATRNVS--FCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAG 1305

Query: 126  QILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEIL 185
            Q+L+ G         +   Y  Q++ L P+LTV + + V A +K   K + +   +T ++
Sbjct: 1306 QVLLKGSGGG--DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVA-ITRLV 1362

Query: 186  TALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245
             AL L     +    LS G +++L   L ++ NP V+  DEP++G+D     Q+   +++
Sbjct: 1363 DALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRA 1422

Query: 246  LAQG-GRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNL 288
              +   R  + T H   A+   + D++ I+  G+    G + +L
Sbjct: 1423 TFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 48/186 (25%), Positives = 71/186 (38%), Gaps = 46/186 (24%)

Query: 96  ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE---LRTFRKMSCYIMQDDML 152
           ++  I+G SGAGKST +NIL+G          + N +  E   L    K++    Q ++ 
Sbjct: 510 QITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQ 569

Query: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
              LTV E + + A +K    QEV KE                                 
Sbjct: 570 FDFLTVRENLRLFAKIKGILPQEVDKE--------------------------------- 596

Query: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272
                   +   DEPT+GLD  S  QV +L+K        +  T     A +  + D+  
Sbjct: 597 --------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADI--LADRKV 646

Query: 273 ILSQGQ 278
            LSQG+
Sbjct: 647 FLSQGK 652


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 71/242 (29%), Positives = 114/242 (47%), Gaps = 34/242 (14%)

Query: 52  HLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTF 111
           HL  R  VD E V  +Y        R R +  +L+ +S      ++  ++GPSG+GKS+ 
Sbjct: 456 HLEGR--VDFENVTFTY--------RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC 505

Query: 112 MNILAG-YRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL 170
           +NIL   Y   G  G++L++G+P      +    Y+ +   L+    VL A  ++ N+  
Sbjct: 506 VNILENFYPLEG--GRVLLDGKPISAYDHK----YLHRVISLVSQEPVLFARSITDNISY 559

Query: 171 SEKQEVKKELVTEILTAL-----------GLMSCSHTRTALLSGGQRKRLAIALELVNNP 219
                V  E+V E                G  + +  + A LSGGQ++R+A+A  LV NP
Sbjct: 560 G-LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 618

Query: 220 PVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS----AKLFEMFDKLYILS 275
           PV+  DE TS LD+ S + +   +    Q   T++   H+ S    A L  + DK  ++ 
Sbjct: 619 PVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 677

Query: 276 QG 277
           QG
Sbjct: 678 QG 679


>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 71/242 (29%), Positives = 114/242 (47%), Gaps = 34/242 (14%)

Query: 52  HLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTF 111
           HL  R  VD E V  +Y        R R +  +L+ +S      ++  ++GPSG+GKS+ 
Sbjct: 499 HLEGR--VDFENVTFTY--------RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC 548

Query: 112 MNILAG-YRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL 170
           +NIL   Y   G  G++L++G+P      +    Y+ +   L+    VL A  ++ N+  
Sbjct: 549 VNILENFYPLEG--GRVLLDGKPISAYDHK----YLHRVISLVSQEPVLFARSITDNISY 602

Query: 171 SEKQEVKKELVTEILTAL-----------GLMSCSHTRTALLSGGQRKRLAIALELVNNP 219
                V  E+V E                G  + +  + A LSGGQ++R+A+A  LV NP
Sbjct: 603 G-LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661

Query: 220 PVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS----AKLFEMFDKLYILS 275
           PV+  DE TS LD+ S + +   +    Q   T++   H+ S    A L  + DK  ++ 
Sbjct: 662 PVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720

Query: 276 QG 277
           QG
Sbjct: 721 QG 722


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 71/242 (29%), Positives = 114/242 (47%), Gaps = 34/242 (14%)

Query: 52  HLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTF 111
           HL  R  VD E V  +Y        R R +  +L+ +S      ++  ++GPSG+GKS+ 
Sbjct: 499 HLEGR--VDFENVTFTY--------RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC 548

Query: 112 MNILAG-YRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL 170
           +NIL   Y   G  G++L++G+P      +    Y+ +   L+    VL A  ++ N+  
Sbjct: 549 VNILENFYPLEG--GRVLLDGKPISAYDHK----YLHRVISLVSQEPVLFARSITDNISY 602

Query: 171 SEKQEVKKELVTEILTAL-----------GLMSCSHTRTALLSGGQRKRLAIALELVNNP 219
                V  E+V E                G  + +  + A LSGGQ++R+A+A  LV NP
Sbjct: 603 G-LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661

Query: 220 PVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS----AKLFEMFDKLYILS 275
           PV+  DE TS LD+ S + +   +    Q   T++   H+ S    A L  + DK  ++ 
Sbjct: 662 PVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720

Query: 276 QG 277
           QG
Sbjct: 721 QG 722


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
           sapiens]
          Length = 1280

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 68/251 (27%), Positives = 113/251 (45%), Gaps = 32/251 (12%)

Query: 44  ITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGP 103
           I    +  H P     ++EF  + +S      +  R    +LK L+ K    + + ++G 
Sbjct: 375 IDSYSKSGHKPDNIKGNLEFRNVHFS------YPSRKEVKILKGLNLKVQSGQTVALVGN 428

Query: 104 SGAGKSTFMNILAGYRESGMKGQILVNG---RPRELRTFRKMSCYIMQDDMLLPHLTVLE 160
           SG GKST + ++    +   +G + V+G   R   +R  R++   + Q+ +L        
Sbjct: 429 SGCGKSTTVQLMQRLYDP-TEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF------- 480

Query: 161 AMMVSANLKLSEKQEVKKELVTEILTALG---LMSCSHT-------RTALLSGGQRKRLA 210
           A  ++ N++   +     E+   +  A     +M   H        R A LSGGQ++R+A
Sbjct: 481 ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 540

Query: 211 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPS----AKLFE 266
           IA  LV NP ++  DE TS LD+ S   VV +    A+ GRT I   H+ S    A +  
Sbjct: 541 IARALVRNPKILLLDEATSALDTES-EAVVQVALDKARKGRTTIVIAHRLSTVRNADVIA 599

Query: 267 MFDKLYILSQG 277
            FD   I+ +G
Sbjct: 600 GFDDGVIVEKG 610



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 50/186 (26%), Positives = 96/186 (51%), Gaps = 10/186 (5%)

Query: 84   LLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMS 143
            +L+ LS +  + + + ++G SG GKST + +L  + +  + G++L++G+  +    + + 
Sbjct: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDP-LAGKVLLDGKEIKRLNVQWLR 1110

Query: 144  CY--IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTAL--GLMSCSHTRTA 199
             +  I+  + +L   ++ E +    N ++  ++E+ +      + A    L +   T+  
Sbjct: 1111 AHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVG 1170

Query: 200  ----LLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIIC 255
                 LSGGQ++R+AIA  LV  P ++  DE TS LD+ S  +VV      A+ GRT I 
Sbjct: 1171 DKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTES-EKVVQEALDKAREGRTCIV 1229

Query: 256  TIHQPS 261
              H+ S
Sbjct: 1230 IAHRLS 1235


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,959,009
Number of Sequences: 37866
Number of extensions: 1055426
Number of successful extensions: 5025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 4750
Number of HSP's gapped (non-prelim): 181
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.