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Search of human proteins with 215598819
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform
1 [Homo sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 1047 0.0
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 953 0.0
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 736 0.0
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 318 7e-87
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 253 4e-67
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 210 2e-54
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 143 4e-34
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 126 4e-29
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 126 4e-29
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 126 4e-29
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 122 6e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 122 6e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 122 6e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 122 6e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 122 6e-28
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 120 3e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 115 7e-26
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 110 2e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 110 4e-24
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 110 4e-24
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 109 5e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 108 9e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 107 3e-23
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 105 1e-22
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 104 2e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 103 3e-22
gi|18079216 CASK interacting protein 1 [Homo sapiens] 103 4e-22
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 103 4e-22
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 103 4e-22
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 102 8e-22
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 1047 bits (2707), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE
Sbjct: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
Query: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA
Sbjct: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL
Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE
Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA
Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS
Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 420
CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST
Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 420
Query: 421 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480
CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS
Sbjct: 421 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480
Query: 481 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512
HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 481 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 953 bits (2463), Expect = 0.0
Identities = 474/512 (92%), Positives = 474/512 (92%), Gaps = 38/512 (7%)
Query: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE
Sbjct: 1 MRGQVSLGAWDTGAFCLSVFPSCSLSLSLPLAYTSPPPHSPFPAHMLMSWSPEECKGQGE 60
Query: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA
Sbjct: 61 PLDDRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILA 120
Query: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL
Sbjct: 121 DSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLL 180
Query: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE
Sbjct: 181 LRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA
Sbjct: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS
Sbjct: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLS 360
Query: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWST 420
CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK
Sbjct: 361 CGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPK------- 413
Query: 421 CPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480
KHQRFYSSLFALVRQPRSLQHLSRCALRS
Sbjct: 414 -------------------------------KHQRFYSSLFALVRQPRSLQHLSRCALRS 442
Query: 481 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512
HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 443 HLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 474
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 736 bits (1899), Expect = 0.0
Identities = 370/412 (89%), Positives = 378/412 (91%), Gaps = 7/412 (1%)
Query: 101 LAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEE 160
+A A+ GD+ + + P S D R + R++ LWSLTYEEE
Sbjct: 48 MALQNALYTGDLARLQELFP-------PHSTADLLLESRAAEPRWSSHQRGLWSLTYEEE 100
Query: 161 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 220
LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN
Sbjct: 101 LTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPN 160
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL
Sbjct: 161 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 220
Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ
Sbjct: 221 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 280
Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400
RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN
Sbjct: 281 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 340
Query: 401 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 460
HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL
Sbjct: 341 HGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSL 400
Query: 461 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 512
FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
Sbjct: 401 FALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY 452
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 318 bits (815), Expect = 7e-87
Identities = 177/361 (49%), Positives = 219/361 (60%), Gaps = 5/361 (1%)
Query: 152 LWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHV 211
LW+L Y+ ELTTPL +AA+ GHT +R LL R A PD++PGGR ALHEAC GHTACV +
Sbjct: 111 LWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRL 170
Query: 212 LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG 271
LL ADP++ +G PLHLCR +L CA+ LL GA V +TPLHVAA+ G
Sbjct: 171 LLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRG 230
Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
E A L L RGA DARN G T L AAC + RCL+LC+LLL GA+
Sbjct: 231 LDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHG-----RCLRLCALLLRRGAE 285
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
ADA D+D++ PLH AC ++ LLL G A +DYGG +PL LQ + AL SP
Sbjct: 286 ADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASP 345
Query: 392 EHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQ 451
+ V+ALLNHG+ VWP A PKVL+ ++ P IEVL N+Y + L E ++ E Q
Sbjct: 346 QRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQ 405
Query: 452 KHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 511
H+ FY SLFAL PR LQHL RCALR +P LPLP L YL L+ +GVL
Sbjct: 406 MHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465
Query: 512 Y 512
+
Sbjct: 466 H 466
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 253 bits (645), Expect = 4e-67
Identities = 151/359 (42%), Positives = 199/359 (55%), Gaps = 9/359 (2%)
Query: 153 WSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL 212
W LT + + T PL +A +RG+T+ R L+R+ A D+ GGR ALHEACA CV +L
Sbjct: 103 WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLL 162
Query: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
L GA N+ ++G PLHLC P +L+CA+LLL GA V+ + E +ETPLHVAA G
Sbjct: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
Query: 273 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 332
+ L L GA R ++G T L AC + + + R LL AGADA
Sbjct: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADA 277
Query: 333 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPE 392
AA + + PLH AC G + ELLL G A + GHTP+ CALQ + PE
Sbjct: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPE 337
Query: 393 HVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQK 452
+ ALL++GA V P++L+ + PR +EVL+N Y V E V V PE ++
Sbjct: 338 VLFAALLDYGAQPV----RPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKE 393
Query: 453 HQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 511
H+ FYSS +V QPR LQHL+R A+R+ L Q RLPLPP L YL L EG +
Sbjct: 394 HEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
Score = 57.8 bits (138), Expect = 2e-08
Identities = 46/126 (36%), Positives = 57/126 (45%), Gaps = 9/126 (7%)
Query: 137 PERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRT 195
PE + + + A +L E TPLHVAA+RG + + L L A G T
Sbjct: 186 PESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGET 245
Query: 196 ALHEACAAG--------HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 247
AL+ ACA H A LL AGAD A + PLH G AELLLR
Sbjct: 246 ALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLR 305
Query: 248 FGARVD 253
+GAR +
Sbjct: 306 YGARAE 311
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 210 bits (535), Expect = 2e-54
Identities = 143/430 (33%), Positives = 211/430 (49%), Gaps = 15/430 (3%)
Query: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
KSG +V R F +A+ + D G + IL + D+VF+ D
Sbjct: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58
Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
+ L S + T LH++ GH E L +LL A + P G+T LH AC
Sbjct: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118
Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSE-EEEETP 263
+ CV +L GA N G LH C P ++ CA+ L+ GA V+ ++ ++EETP
Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178
Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
LH AA G EL + GA D+ NA TPL A + + E +T L +C
Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALR-FKEQEYSTEHHL-VCR 236
Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
+LL A+ +A D D + PLH A ++ ++L G AN MD G + L+
Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296
Query: 384 AAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVG 443
+ A PE + LLNHGA R++P KV++ +CP+ IEV++N Y ++ +
Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRR 356
Query: 444 LVTPETLQKHQRFYSSLFAL-VRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRY 502
+ + L+K+ FY SLF + PR+L HLSRCA+R L +A+P L LP L +Y
Sbjct: 357 AIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKY 416
Query: 503 LQLDFEGVLY 512
L L+ EG++Y
Sbjct: 417 LLLEPEGIIY 426
>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
isoform b [Homo sapiens]
Length = 349
Score = 143 bits (360), Expect = 4e-34
Identities = 106/331 (32%), Positives = 151/331 (45%), Gaps = 14/331 (4%)
Query: 85 KSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPERWRDFR 144
KSG +V R F +A+ + D G + IL + D+VF+ D
Sbjct: 10 KSGAAKLVKRN-------FLEALKSNDFGKLKAILIQRQIDV--DTVFEVEDENMV--LA 58
Query: 145 FNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAG 204
+ L S + T LH++ GH E L +LL A + P G+T LH AC
Sbjct: 59 SYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMA 118
Query: 205 HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGR-SEEEEETP 263
+ CV +L GA N G LH C P ++ CA+ L+ GA V+ + + ++EETP
Sbjct: 119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETP 178
Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
LH AA G EL + GA D+ NA TPL A + E +T L +C
Sbjct: 179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAA-YWALRFKEQEYSTEHHL-VCR 236
Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
+LL A+ +A D D + PLH A ++ ++L G AN MD G + L+
Sbjct: 237 MLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVT 296
Query: 384 AAALAQSPEHVVRALLNHGAVRVWPGALPKV 414
+ A PE + LLNHGA R++P KV
Sbjct: 297 SVRPAAQPEICYQLLLNHGAARIYPPQFHKV 327
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 126 bits (317), Expect = 4e-29
Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 593
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
LL +GA P A G+TPL A +Q+ S LL+ GA+ + +
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 640
Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
PLHLA + GH +V LLL G + + G T LH A Q + +V L
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 693
Query: 399 LNHGA 403
HGA
Sbjct: 694 TKHGA 698
Score = 123 bits (309), Expect = 3e-28
Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 497
Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
A PDA G+TPL + DV S+ + T L +
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A +
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
Query: 382 GPAAALAQSPEHVVRALLNHGA 403
++ + LLN+GA
Sbjct: 618 -------KNQMQIASTLLNYGA 632
Score = 121 bits (304), Expect = 1e-27
Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 603
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 662
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA G T L A ++ D +L GAD DA +
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 709
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 762
Query: 402 GA 403
GA
Sbjct: 763 GA 764
Score = 115 bits (289), Expect = 7e-26
Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
+PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 372
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 431
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA PD N G T L A + RC LL GA DA +++Q
Sbjct: 432 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 478
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
PLH+A R G +V+LLL + G+TPLH
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 514
Score = 109 bits (272), Expect = 7e-24
Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLHL G + LLL GA + S + T LH+AA+ V +AD+L +
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 695
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA DA G+TPL+ AC +++ + LL GA+ +A ++
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 742
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A ++GH ++ +LL G N G+T L A
Sbjct: 743 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Score = 100 bits (248), Expect = 4e-21
Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL++AA H +V++ LL A +A G T L A GH V +LL
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 164
Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
D GK LH+ + A LLL+ D R+ E TPLH+AA G
Sbjct: 165 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 223
Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
+V +A LLL RGA D G TPL + T + LLL G
Sbjct: 224 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 270
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
DA +D PLH A R GH VVELLL G G +PLH A QG
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 321
Query: 392 EHV--VRALLNHGA 403
+HV V+ LL H A
Sbjct: 322 DHVECVKHLLQHKA 335
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G +
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 332
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
A D + T L A +T LLL A+ +A +
Sbjct: 333 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 379
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH+AC++ V+ELL+ G S + G TP+H A
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417
Score = 90.1 bits (222), Expect = 4e-18
Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 165
Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
D ++A DV+ + + + + +
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 225
Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
+ +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285
Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
+ + VV LL GA
Sbjct: 286 AR-------SGHDQVVELLLERGA 302
Score = 78.2 bits (191), Expect = 2e-14
Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD +
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 761
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+A A G T L A + S+ D
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVD 790
Score = 75.9 bits (185), Expect = 8e-14
Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)
Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA +
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
+ +S + TPL++AA+ H+++ LL GA +G+TPL A
Sbjct: 103 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
D + + A AR S L D +A Q K PLH+A
Sbjct: 162 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 221
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G
Sbjct: 222 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 268
Score = 65.9 bits (159), Expect = 9e-11
Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 14/160 (8%)
Query: 200 ACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEE 259
A AG+ V L G D N +Q+G LHL G + + LL G+ VD + ++
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 75
Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319
T LH+A+ G E+ +L++ GA +A++ G+TPL A +
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ-------------ENHI 122
Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
+ LL GA+ A +D PL +A ++GH V +LL
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
+G L + + G + + L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A
Sbjct: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 83
Query: 386 ALAQSPEHVVRALLNHGA 403
+LA E VV+ L+ GA
Sbjct: 84 SLAGQAE-VVKVLVKEGA 100
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 126 bits (317), Expect = 4e-29
Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
LL +GA P A G+TPL A +Q+ S LL+ GA+ + +
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661
Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
PLHLA + GH +V LLL G + + G T LH A Q + +V L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714
Query: 399 LNHGA 403
HGA
Sbjct: 715 TKHGA 719
Score = 123 bits (309), Expect = 3e-28
Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518
Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
A PDA G+TPL + DV S+ + T L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 382 GPAAALAQSPEHVVRALLNHGA 403
++ + LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653
Score = 121 bits (304), Expect = 1e-27
Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA G T L A ++ D +L GAD DA +
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783
Query: 402 GA 403
GA
Sbjct: 784 GA 785
Score = 115 bits (289), Expect = 7e-26
Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
+PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA PD N G T L A + RC LL GA DA +++Q
Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
PLH+A R G +V+LLL + G+TPLH
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Score = 109 bits (272), Expect = 7e-24
Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLHL G + LLL GA + S + T LH+AA+ V +AD+L +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA DA G+TPL+ AC +++ + LL GA+ +A ++
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A ++GH ++ +LL G N G+T L A
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 100 bits (248), Expect = 4e-21
Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL++AA H +V++ LL A +A G T L A GH V +LL
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185
Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
D GK LH+ + A LLL+ D R+ E TPLH+AA G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244
Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
+V +A LLL RGA D G TPL + T + LLL G
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
DA +D PLH A R GH VVELLL G G +PLH A QG
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342
Query: 392 EHV--VRALLNHGA 403
+HV V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
A D + T L A +T LLL A+ +A +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH+AC++ V+ELL+ G S + G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 90.1 bits (222), Expect = 4e-18
Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
D ++A DV+ + + + + +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
+ +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
+ + VV LL GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323
Score = 78.2 bits (191), Expect = 2e-14
Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD +
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+A A G T L A + S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811
Score = 75.9 bits (185), Expect = 8e-14
Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)
Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA +
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
+ +S + TPL++AA+ H+++ LL GA +G+TPL A
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
D + + A AR S L D +A Q K PLH+A
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289
Score = 70.1 bits (170), Expect = 5e-12
Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)
Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241
+RR RP + + L A AG+ V L G D N +Q+G LHL G +
Sbjct: 21 QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79
Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301
+ LL G+ VD + ++ T LH+A+ G E+ +L++ GA +A++ G+TPL A
Sbjct: 80 VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
+ + LL GA+ A +D PL +A ++GH V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
+G L + + G + + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104
Query: 386 ALAQSPEHVVRALLNHGA 403
+LA E VV+ L+ GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 126 bits (317), Expect = 4e-29
Identities = 89/245 (36%), Positives = 123/245 (50%), Gaps = 22/245 (8%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGAD 218
E TPLH+A+ G TE+++LLL+ A PD+A G T LH + G VLL AGA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
++A + G PLH+ G+L+ A+LLL+ A D + TPLHVAA + ++A L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL-TPLHVAAHYDNQKVALL 614
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
LL +GA P A G+TPL A +Q+ S LL+ GA+ + +
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAK-------------KNQMQIASTLLNYGAETNIVTKQ 661
Query: 339 KQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRAL 398
PLHLA + GH +V LLL G + + G T LH A Q + +V L
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ-------EDKVNVADIL 714
Query: 399 LNHGA 403
HGA
Sbjct: 715 TKHGA 719
Score = 123 bits (309), Expect = 3e-28
Identities = 89/262 (33%), Positives = 127/262 (48%), Gaps = 29/262 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A + +V+ LL++ A + G T +H A GH V +LL GA P++
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G+ LH+ G +E LLR GA VD R+ EE+TPLH+A+RLG E+ LLL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQ 518
Query: 282 RGACPDARNAEGWTPLLAAC-----DV--------RCQSITDAEATTA-------RCLQL 321
A PDA G+TPL + DV S+ + T L +
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
LLL A AD+A ++ PLH+A + V LLL G S + G+TPLH A +
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 382 GPAAALAQSPEHVVRALLNHGA 403
++ + LLN+GA
Sbjct: 639 -------KNQMQIASTLLNYGA 653
Score = 121 bits (304), Expect = 1e-27
Identities = 84/242 (34%), Positives = 117/242 (48%), Gaps = 22/242 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G +V +LLL+RRA DSA G T LH A + +LL GA P+
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA 624
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G PLH+ ++ A LL +GA + +++ TPLH+A++ GH ++ LLL
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTLLLD 683
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA G T L A ++ D +L GAD DA +
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVAD-------------ILTKHGADQDAHTKLGYT 730
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL +AC G+ +V LL G + N G+TPLH A Q Q H++ LL H
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQH 783
Query: 402 GA 403
GA
Sbjct: 784 GA 785
Score = 115 bits (289), Expect = 7e-26
Identities = 77/216 (35%), Positives = 108/216 (50%), Gaps = 15/216 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
+PLH+AA H E ++ LL+ +A D TALH A GH +LL A+PN
Sbjct: 334 SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA 393
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ ++ ELL+++GA + + E TP+HVAA +GH+ + LLL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA PD N G T L A + RC LL GA DA +++Q
Sbjct: 453 NGASPDVTNIRGETALHMAARA-------GQVEVVRC------LLRNGALVDARAREEQT 499
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
PLH+A R G +V+LLL + G+TPLH
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLH 535
Score = 109 bits (272), Expect = 7e-24
Identities = 75/218 (34%), Positives = 105/218 (48%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA + +V LLL + A P + A G T LH A LL GA+ NI
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLHL G + LLL GA + S + T LH+AA+ V +AD+L +
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIH-MSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA DA G+TPL+ AC +++ + LL GA+ +A ++
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGN-------------VKMVNFLLKQGANVNAKTKNGYT 763
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A ++GH ++ +LL G N G+T L A
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 100 bits (248), Expect = 4e-21
Identities = 88/254 (34%), Positives = 108/254 (42%), Gaps = 42/254 (16%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL++AA H +V++ LL A +A G T L A GH V +LL
Sbjct: 132 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN------ 185
Query: 222 ADQDGK---RPLHLCRGPGTLECAELLLRFGARVD-------GRSEEEEETPLHVAARLG 271
D GK LH+ + A LLL+ D R+ E TPLH+AA G
Sbjct: 186 -DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYG 244
Query: 272 HVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
+V +A LLL RGA D G TPL + T + LLL G
Sbjct: 245 NVNVATLLLNRGAAVDFTARNGITPL---------HVASKRGNT----NMVKLLLDRGGQ 291
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
DA +D PLH A R GH VVELLL G G +PLH A QG
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--------- 342
Query: 392 EHV--VRALLNHGA 403
+HV V+ LL H A
Sbjct: 343 DHVECVKHLLQHKA 356
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/218 (34%), Positives = 103/218 (47%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA G+ V LLL R A D +A G T LH A G+T V +LL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+DG PLH G + ELLL GA + R++ +PLH+AA+ HVE LL+
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQ 353
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
A D + T L A +T LLL A+ +A +
Sbjct: 354 HKAPVDDVTLDYLTALHVAAHCGHYRVT-------------KLLLDKRANPNARALNGFT 400
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH+AC++ V+ELL+ G S + G TP+H A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 90.1 bits (222), Expect = 4e-18
Identities = 78/264 (29%), Positives = 117/264 (44%), Gaps = 33/264 (12%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
LH+AA GH +++ LL R + DSA G TALH A AG V VL+ GA+ N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR- 282
Q+G PL++ ++ + LL GA + E+ TPL VA + GH + +LL
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN-QSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 283 -------------GACPDARNAEGWTPLLAACDVRCQSITDAEATTARC----------L 319
D ++A DV+ + + + + +
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNV 246
Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
+ +LLL+ GA D ++ PLH+A +RG+ +V+LLL G + G TPLHCA
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 306
Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
+ + VV LL GA
Sbjct: 307 AR-------SGHDQVVELLLERGA 323
Score = 78.2 bits (191), Expect = 2e-14
Identities = 52/149 (34%), Positives = 78/149 (52%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ GHT+++ LLL + A S G T+LH A +L GAD +
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PL + G ++ LL+ GA V+ +++ TPLH AA+ GH + ++LL+
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQAAQQGHTHIINVLLQ 782
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+A A G T L A + S+ D
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVD 811
Score = 75.9 bits (185), Expect = 8e-14
Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 32/234 (13%)
Query: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARV 252
G ALH A GH V LL G+ + A + G LH+ G E ++L++ GA +
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 253 DGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC----------- 301
+ +S + TPL++AA+ H+++ LL GA +G+TPL A
Sbjct: 124 NAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 302 ---DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ----------RPLHLACR 348
D + + A AR S L D +A Q K PLH+A
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
G+ V LLL+ G + + G TPLH A + + ++V+ LL+ G
Sbjct: 243 YGNVNVATLLLNRGAAVDFTARNGITPLHVASK-------RGNTNMVKLLLDRG 289
Score = 70.1 bits (170), Expect = 5e-12
Identities = 53/178 (29%), Positives = 83/178 (46%), Gaps = 15/178 (8%)
Query: 182 RRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLEC 241
+RR RP + + L A AG+ V L G D N +Q+G LHL G +
Sbjct: 21 QRRKRPKKSDSNASFLR-AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL 79
Query: 242 AELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAAC 301
+ LL G+ VD + ++ T LH+A+ G E+ +L++ GA +A++ G+TPL A
Sbjct: 80 VQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 302 DVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
+ + LL GA+ A +D PL +A ++GH V +LL
Sbjct: 139 Q-------------ENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL VA G+ +++ LL++ A ++ G T LH+A GHT ++VLL GA PN
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
+G L + + G + + L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V+ LL G S ++ G+T LH A
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH------IA 104
Query: 386 ALAQSPEHVVRALLNHGA 403
+LA E VV+ L+ GA
Sbjct: 105 SLAGQAE-VVKVLVKEGA 121
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 122 bits (307), Expect = 6e-28
Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA
Sbjct: 274 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 392
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA P++R G+TPL AC +++ LLL GA DA +
Sbjct: 393 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 439
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
PLH+A GH +V+ LL G S N + TPLH A + +A+
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 487
Score = 120 bits (302), Expect = 2e-27
Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 587
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL R A P+A G TPL A I A
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
+++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707
Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
Q + V L+ HG +
Sbjct: 708 VAQ-------EGHVPVADVLIKHGVM 726
Score = 119 bits (297), Expect = 9e-27
Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 458
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
RGA P+ N + TPL A A ++ LL A +A +D Q
Sbjct: 459 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 505
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A R GH +V+LLL + N GHTPLH A
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543
Score = 110 bits (275), Expect = 3e-24
Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 689
Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
+ A + N G TPL + DV + +ATT ++L
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LL AD +A + PLH A ++GH +V LLL G S N + G TPL A
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 101 bits (251), Expect = 2e-21
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)
Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
E+ TPL VA +GH T +LL+ PD
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234
Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
+ G T LH A + +LL GA N Q+G PLH+ G + LLL
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294
Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P
Sbjct: 295 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
LL D IT T A C ++ +LL GA ++ + PLH+AC+
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+ H V+ELLL G S + + G TPLH A+ + P +V+ LL GA
Sbjct: 414 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 461
Score = 97.4 bits (241), Expect = 3e-20
Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A +DG PL + G L+ +G + R LH+AAR A +LL+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 227
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
PD + G+TPL A L + LLL+ GA + Q+
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 274
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 327
Query: 402 GA 403
GA
Sbjct: 328 GA 329
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G +
Sbjct: 670 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 729
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 788
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+ +++G TPL A + S+TD
Sbjct: 789 NGASPNEVSSDGTTPLAIAKRLGYISVTD 817
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ G+ ++++ LL+ +A ++ G + LH+A GHT V +LL GA PN
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
DG PL + + G + ++L
Sbjct: 796 VSSDGTTPLAIAKRLGYISVTDVL 819
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V LL + T G+T LH A
Sbjct: 65 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 118
Query: 386 ALAQSPEHVVRALLNHGA 403
ALA E VVR L+N+GA
Sbjct: 119 ALAGQDE-VVRELVNYGA 135
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 122 bits (307), Expect = 6e-28
Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA P++R G+TPL AC +++ LLL GA DA +
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
PLH+A GH +V+ LL G S N + TPLH A + +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Score = 120 bits (302), Expect = 2e-27
Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL R A P+A G TPL A I A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
+++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
Q + V L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693
Score = 119 bits (297), Expect = 9e-27
Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
RGA P+ N + TPL A A ++ LL A +A +D Q
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A R GH +V+LLL + N GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Score = 110 bits (275), Expect = 3e-24
Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
+ A + N G TPL + DV + +ATT ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LL AD +A + PLH A ++GH +V LLL G S N + G TPL A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 101 bits (251), Expect = 2e-21
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)
Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
E+ TPL VA +GH T +LL+ PD
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
+ G T LH A + +LL GA N Q+G PLH+ G + LLL
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
LL D IT T A C ++ +LL GA ++ + PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+ H V+ELLL G S + + G TPLH A+ + P +V+ LL GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428
Score = 97.4 bits (241), Expect = 3e-20
Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A +DG PL + G L+ +G + R LH+AAR A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
PD + G+TPL A L + LLL+ GA + Q+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294
Query: 402 GA 403
GA
Sbjct: 295 GA 296
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G +
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+ +++G TPL A + S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ G+ ++++ LL+ +A ++ G + LH+A GHT V +LL GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
DG PL + + G + ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V LL + T G+T LH A
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85
Query: 386 ALAQSPEHVVRALLNHGA 403
ALA E VVR L+N+GA
Sbjct: 86 ALAGQDE-VVRELVNYGA 102
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 122 bits (307), Expect = 6e-28
Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA P++R G+TPL AC +++ LLL GA DA +
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
PLH+A GH +V+ LL G S N + TPLH A + +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Score = 120 bits (302), Expect = 2e-27
Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL R A P+A G TPL A I A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
+++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
Q + V L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693
Score = 119 bits (297), Expect = 9e-27
Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
RGA P+ N + TPL A A ++ LL A +A +D Q
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A R GH +V+LLL + N GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Score = 110 bits (275), Expect = 3e-24
Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
+ A + N G TPL + DV + +ATT ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LL AD +A + PLH A ++GH +V LLL G S N + G TPL A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 101 bits (251), Expect = 2e-21
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)
Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
E+ TPL VA +GH T +LL+ PD
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
+ G T LH A + +LL GA N Q+G PLH+ G + LLL
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
LL D IT T A C ++ +LL GA ++ + PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+ H V+ELLL G S + + G TPLH A+ + P +V+ LL GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428
Score = 97.4 bits (241), Expect = 3e-20
Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A +DG PL + G L+ +G + R LH+AAR A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
PD + G+TPL A L + LLL+ GA + Q+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294
Query: 402 GA 403
GA
Sbjct: 295 GA 296
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G +
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+ +++G TPL A + S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ G+ ++++ LL+ +A ++ G + LH+A GHT V +LL GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
DG PL + + G + ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V LL + T G+T LH A
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85
Query: 386 ALAQSPEHVVRALLNHGA 403
ALA E VVR L+N+GA
Sbjct: 86 ALAGQDE-VVRELVNYGA 102
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 122 bits (307), Expect = 6e-28
Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA P++R G+TPL AC +++ LLL GA DA +
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
PLH+A GH +V+ LL G S N + TPLH A + +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Score = 120 bits (302), Expect = 2e-27
Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL R A P+A G TPL A I A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
+++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
Q + V L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693
Score = 119 bits (297), Expect = 9e-27
Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
RGA P+ N + TPL A A ++ LL A +A +D Q
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A R GH +V+LLL + N GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Score = 110 bits (275), Expect = 3e-24
Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
+ A + N G TPL + DV + +ATT ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LL AD +A + PLH A ++GH +V LLL G S N + G TPL A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 101 bits (251), Expect = 2e-21
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)
Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
E+ TPL VA +GH T +LL+ PD
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
+ G T LH A + +LL GA N Q+G PLH+ G + LLL
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
LL D IT T A C ++ +LL GA ++ + PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+ H V+ELLL G S + + G TPLH A+ + P +V+ LL GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428
Score = 97.4 bits (241), Expect = 3e-20
Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A +DG PL + G L+ +G + R LH+AAR A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
PD + G+TPL A L + LLL+ GA + Q+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294
Query: 402 GA 403
GA
Sbjct: 295 GA 296
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G +
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+ +++G TPL A + S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ G+ ++++ LL+ +A ++ G + LH+A GHT V +LL GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
DG PL + + G + ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V LL + T G+T LH A
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85
Query: 386 ALAQSPEHVVRALLNHGA 403
ALA E VVR L+N+GA
Sbjct: 86 ALAGQDE-VVRELVNYGA 102
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 122 bits (307), Expect = 6e-28
Identities = 80/228 (35%), Positives = 116/228 (50%), Gaps = 15/228 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+A+ RG+ ++RLLL R A+ ++ T LH A GH +LL GA
Sbjct: 241 TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G P+H+ L+C LLL++ A +D + + TPLHVAA GH +A +LL
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL-TPLHVAAHCGHHRVAKVLLD 359
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA P++R G+TPL AC +++ LLL GA DA +
Sbjct: 360 KGAKPNSRALNGFTPLHIACK-------------KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
PLH+A GH +V+ LL G S N + TPLH A + +A+
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Score = 120 bits (302), Expect = 2e-27
Identities = 91/266 (34%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 160 ELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGAD 218
++ TPLH+AA GHTEV + LL+ +A+ ++ A +T LH A GHT V +LL A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
PN+A G PLH+ G +E LL A ++ TPLHVAA+ G V +A+L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL R A P+A G TPL A I A
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
+++ LL G A+A PLHLA + GHA +V LLLS + N + G TPLH
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 379 ALQGPAAALAQSPEHVVRALLNHGAV 404
Q + V L+ HG +
Sbjct: 675 VAQ-------EGHVPVADVLIKHGVM 693
Score = 119 bits (297), Expect = 9e-27
Identities = 81/218 (37%), Positives = 107/218 (49%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+P+H+AA H + +RLLL+ A D T LH A GH VLL GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ + ELLL+ GA +D +E TPLHVA+ +GH+ + LL+
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHVASFMGHLPIVKNLLQ 425
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
RGA P+ N + TPL A A ++ LL A +A +D Q
Sbjct: 426 RGASPNVSNVKVETPLHMAA-------------RAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A R GH +V+LLL + N GHTPLH A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Score = 110 bits (275), Expect = 3e-24
Identities = 83/238 (34%), Positives = 111/238 (46%), Gaps = 22/238 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G V LLL R A P++A G T LH A + V +LL G P+
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ +E A LL++G + S + TPLH+AA+ GH E+ LLL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLS 656
Query: 282 RGACPDARNAEGWTPL--------LAACDVRCQSITDAEATTARC------------LQL 321
+ A + N G TPL + DV + +ATT ++L
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LL AD +A + PLH A ++GH +V LLL G S N + G TPL A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 101 bits (251), Expect = 2e-21
Identities = 89/295 (30%), Positives = 128/295 (43%), Gaps = 58/295 (19%)
Query: 159 EELTTPLHVAASRGH-----------------------------TEVLRLLLRRRARPD- 188
E+ TPL VA +GH T +LL+ PD
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 189 SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRF 248
+ G T LH A + +LL GA N Q+G PLH+ G + LLL
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 249 GARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP------------ 296
GA+++ ++ ++E TPLH AAR GHV ++++LL GA A+ G +P
Sbjct: 262 GAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 297 --LLAACDVRCQSITDAEAT----TARC--LQLCSLLLSAGADADAADQDKQRPLHLACR 348
LL D IT T A C ++ +LL GA ++ + PLH+AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 349 RGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+ H V+ELLL G S + + G TPLH A+ + P +V+ LL GA
Sbjct: 381 KNHVRVMELLLKTGASIDAVTESGLTPLHV-----ASFMGHLP--IVKNLLQRGA 428
Score = 97.4 bits (241), Expect = 3e-20
Identities = 77/242 (31%), Positives = 108/242 (44%), Gaps = 26/242 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L+ A ++ + G T L+ A H V LL GA+ N+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A +DG PL + G L+ +G + R LH+AAR A +LL+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA-----LHIAARNDDTRTAAVLLQ 194
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
PD + G+TPL A L + LLL+ GA + Q+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYEN-------------LNVAQLLLNRGASVNFTPQNGIT 241
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH+A RRG+ +V LLL G T TPLHCA + +++ LL+H
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE-------ILLDH 294
Query: 402 GA 403
GA
Sbjct: 295 GA 296
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/149 (34%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA GH E++ LLL ++A + G T LH GH VL+ G +
Sbjct: 637 TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA 696
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+ G PLH+ G ++ + LL+ A V+ +++ +PLH AA+ GH ++ LLL+
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLK 755
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITD 310
GA P+ +++G TPL A + S+TD
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/84 (35%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ G+ ++++ LL+ +A ++ G + LH+A GHT V +LL GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 222 ADQDGKRPLHLCRGPGTLECAELL 245
DG PL + + G + ++L
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVL 786
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 7/78 (8%)
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAA 385
L G D + +Q+ LHLA + GH +V LL + T G+T LH A
Sbjct: 32 LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH------IA 85
Query: 386 ALAQSPEHVVRALLNHGA 403
ALA E VVR L+N+GA
Sbjct: 86 ALAGQDE-VVRELVNYGA 102
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 120 bits (301), Expect = 3e-27
Identities = 83/242 (34%), Positives = 114/242 (47%), Gaps = 22/242 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
+PLH+A H ++LLL+ D TALH A GH VLL A+PN
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+G PLH+ ++ ELLL+ GA + +E TP+HVAA +GHV + L+
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVSQLMH 454
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA P+ N G T L A +A R L+ GA +A +D Q
Sbjct: 455 HGASPNTTNVRGETALHMAA-------RSGQAEVVR------YLVQDGAQVEAKAKDDQT 501
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PLH++ R G A +V+ LL G S N G+TPLH + + + E V LL+H
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR-------EGHEDVAAFLLDH 554
Query: 402 GA 403
GA
Sbjct: 555 GA 556
Score = 119 bits (298), Expect = 7e-27
Identities = 83/243 (34%), Positives = 119/243 (48%), Gaps = 24/243 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA G EV LLL++ A PD+A G T LH A + +LL GA P+
Sbjct: 567 TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA 626
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A ++G PLH+ ++ A LL +GA + + + + +H+AA+ GHV++ LLL
Sbjct: 627 AAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAS-VHLAAQEGHVDMVSLLLG 685
Query: 282 RGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
R A + N G TPL LAA + R + + +L++ GA DA +
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDR--------------VNVAEVLVNQGAHVDAQTKMGY 731
Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLN 400
PLH+ C G+ +V LL N G+TPLH A Q Q H++ LL
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQ-------QGHTHIINVLLQ 784
Query: 401 HGA 403
+ A
Sbjct: 785 NNA 787
Score = 119 bits (297), Expect = 9e-27
Identities = 84/242 (34%), Positives = 118/242 (48%), Gaps = 22/242 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVA+ RG+ +++LLL R A+ D+ G T LH +GH V +LL A
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
++G PLH+ L C +LLL+ VD + + T LHVAA GH ++A +LL
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLD 388
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+ A P+A+ G+TPL AC +++ LLL GA A +
Sbjct: 389 KKANPNAKALNGFTPLHIAC-------------KKNRIKVMELLLKHGASIQAVTESGLT 435
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
P+H+A GH +V L+ G S NT + G T LH A + A VVR L+
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA-------EVVRYLVQD 488
Query: 402 GA 403
GA
Sbjct: 489 GA 490
Score = 118 bits (296), Expect = 1e-26
Identities = 89/262 (33%), Positives = 124/262 (47%), Gaps = 29/262 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T LH+AA G EV+R L++ A+ ++ A +T LH + G V LL GA PN
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A G PLHL G + A LL GA + + ++ TPLHVAA+ G +E+A+LLL+
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLS-ITTKKGFTPLHVAAKYGKLEVANLLLQ 586
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSIT----DAEATTARC----------------LQL 321
+ A PDA G TPL A Q + D A+ + +
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
+ LL GADA+A + +HLA + GH +V LLL + N + G TPLH A Q
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Query: 382 GPAAALAQSPEHVVRALLNHGA 403
+ +V L+N GA
Sbjct: 707 -------EDRVNVAEVLVNQGA 721
Score = 101 bits (251), Expect = 2e-21
Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
LH+A+ GH EV+ LL+R A D+A G TALH A AG V VL+ GA+ N
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
Q+G PL++ LE + LL GA + E+ TPL VA + GH ++ LLL
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 284 ACPDAR------NAEGWTPLLAACDVRCQSITDAEATTARC----------LQLCSLLLS 327
R A AA ++ + D E+ + + + +LLL+
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387
A D ++ PLH+A +RG+A +V+LLL G + G TPLHC +
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR------ 310
Query: 388 AQSPEHVVRALLNHGA 403
E VV LL+ A
Sbjct: 311 -SGHEQVVEMLLDRAA 325
Score = 94.0 bits (232), Expect = 3e-19
Identities = 79/265 (29%), Positives = 110/265 (41%), Gaps = 31/265 (11%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218
E+ TPL VA +GH +V+ LLL + ALH A T +LL +
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTK---GKVRLPALHIAARKDDTKAAALLLQNDNN 227
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
++ + G PLH+ G + A LLL A VD + + TPLHVA++ G+ + L
Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTARNDITPLHVASKRGNANMVKL 286
Query: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDA--------------------EATTARC 318
LL RGA DA+ +G TPL + + + AT
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 319 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 378
L LLL D D LH+A GH V ++LL + N G TPLH
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Query: 379 ALQGPAAALAQSPEHVVRALLNHGA 403
A + ++ V+ LL HGA
Sbjct: 407 ACK-------KNRIKVMELLLKHGA 424
Score = 73.6 bits (179), Expect = 4e-13
Identities = 56/179 (31%), Positives = 82/179 (45%), Gaps = 15/179 (8%)
Query: 182 RRRARPDSAPGGRTALH-EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLE 240
R+R+R A + A AGH + G D NI +Q+G LHL G +E
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 241 CAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAA 300
LL+ A VD + ++ T LH+A+ G E+ +L+ GA +A++ G+TPL A
Sbjct: 89 VVSELLQREANVDA-ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147
Query: 301 CDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLL 359
L++ LL GA A +D PL +A ++GH VV LLL
Sbjct: 148 AQ-------------ENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Score = 68.6 bits (166), Expect = 1e-11
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 2/147 (1%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIAD 223
+H+AA GH +++ LLL R A + S G T LH A VL+ GA +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRG 283
+ G PLH+ G ++ LL+ A+V+ +++ TPLH AA+ GH + ++LL+
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAAQQGHTHIINVLLQNN 786
Query: 284 ACPDARNAEGWTPLLAACDVRCQSITD 310
A P+ G T L A + S+ D
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVD 813
Score = 59.7 bits (143), Expect = 6e-09
Identities = 48/146 (32%), Positives = 71/146 (48%), Gaps = 23/146 (15%)
Query: 264 LHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCS 323
LH+A++ GHVE+ LL+R A DA +G T L A + A ++
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIA-------------SLAGQAEVVK 124
Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
+L++ GA+ +A Q+ PL++A + H VV+ LL G S + G TPL
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL------- 177
Query: 384 AAALAQSPEHVVRALLNH---GAVRV 406
A AL Q + VV LL + G VR+
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRL 203
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 2/127 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHV G+ +++ LL+ A+ ++ G T LH+A GHT ++VLL A PN
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV-ELADLLL 280
+G L + R G + + L + E+ ++V + V +++D +
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851
Query: 281 RRGACPD 287
R+ P+
Sbjct: 852 RKANAPE 858
Score = 49.7 bits (117), Expect = 6e-06
Identities = 41/137 (29%), Positives = 63/137 (45%), Gaps = 20/137 (14%)
Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
AAR GH+E A ++ G + N G L A + +++ S LL
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLA-------------SKEGHVEVVSELL 94
Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
A+ DAA + LH+A G A VV++L++ G + N G TPL+ A Q
Sbjct: 95 QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ----- 149
Query: 387 LAQSPEHVVRALLNHGA 403
++ VV+ LL++GA
Sbjct: 150 --ENHLEVVKFLLDNGA 164
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 115 bits (289), Expect = 7e-26
Identities = 82/226 (36%), Positives = 109/226 (48%), Gaps = 17/226 (7%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAG 216
E E TPLH+AA V RLL+ R+A P+ G+T LH A GH + V +L G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
A+ + ++ + PLHL G + + LL+ GA D ++ PLH AA G +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDAL-DQSGYGPLHTAAARGKYLIC 576
Query: 277 DLLLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
+LLR GA + +GWTPL LAA L++ LL + A+ A
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGH--------------LEIIHLLAESHANMGAL 622
Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
PLHLA R G AVV LL CG N + G TPLH A+Q
Sbjct: 623 GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668
Score = 114 bits (284), Expect = 3e-25
Identities = 88/246 (35%), Positives = 112/246 (45%), Gaps = 22/246 (8%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGA 217
E TPLH ++G E +RLLL D G T L A +LL GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
D N D+DG PLH G A LLL GA VD + E E TPLH+AA+ +A
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVAR 478
Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337
LL+ R A P+ AEG TPL A S L LL S GA+ DA +
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVS-------------LVKLLTSQGAELDAQQR 525
Query: 338 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 397
+ + PLHLA RG ++ LL G + +D G+ PLH A A+ + +
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLH-------TAAARGKYLICKM 578
Query: 398 LLNHGA 403
LL +GA
Sbjct: 579 LLRYGA 584
Score = 112 bits (280), Expect = 8e-25
Identities = 84/233 (36%), Positives = 112/233 (48%), Gaps = 16/233 (6%)
Query: 157 YEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVA 215
+E E TPLHVAA GH +++LL + A D+ RT LH A G + LL +
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVEL 275
GA P+ DQ G PLH G ++LLR+GA ++ + TPLH+AA GH+E+
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE-LPTHQGWTPLHLAAYKGHLEI 608
Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
LL A A A WTPL A +++ A LL GAD +AA
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA-------------LLQCGADPNAA 655
Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAAL 387
+Q PLHLA +R V LL + + + G TP H AL+G A L
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Score = 90.1 bits (222), Expect = 4e-18
Identities = 77/218 (35%), Positives = 96/218 (44%), Gaps = 15/218 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL +AA ++ LLL A + G LH A G +LL GA +
Sbjct: 397 TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+++G PLHL A LL+ A E E +TPLHVAA GHV L LL
Sbjct: 457 QEREGWTPLHLAAQNNFENVARLLVSRQAD-PNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA DA+ TPL A E R +Q LL +GA DA DQ
Sbjct: 516 QGAELDAQQRNLRTPLHLA----------VERGKVRAIQ---HLLKSGAVPDALDQSGYG 562
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
PLH A RG + ++LL G S + G TPLH A
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Score = 79.7 bits (195), Expect = 6e-15
Identities = 56/147 (38%), Positives = 71/147 (48%), Gaps = 2/147 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA +GH E++ LL A + T LH A G A V LL GADPN
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
A+Q G PLHL T LL A V R+ + TP H+AA G+ + +L+
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAILKVLVE 713
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSI 308
GA D ++ TPL A R Q I
Sbjct: 714 AGAQLDVQDGVSCTPLQLALRSRKQGI 740
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/234 (29%), Positives = 99/234 (42%), Gaps = 38/234 (16%)
Query: 258 EEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTAR 317
E + TPLH G VE LLL D + A G+TPLL A D +
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-------DQQP---- 408
Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
LC+LLL+ GADA+ D+D PLH A + G LLL G + + G TPLH
Sbjct: 409 --DLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLH 466
Query: 378 CALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQ- 436
A Q + E+V R L++ A P + E P + S+V+
Sbjct: 467 LAAQ-------NNFENVARLLVSRQAD-------PNLHEAEGKTPLHVAAYFGHVSLVKL 512
Query: 437 LPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQAL 490
L + L + Q++ R L + R++QHL + G++P AL
Sbjct: 513 LTSQGAEL---DAQQRNLRTPLHLAVERGKVRAIQHLLK-------SGAVPDAL 556
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 110 bits (276), Expect = 2e-24
Identities = 101/334 (30%), Positives = 141/334 (42%), Gaps = 33/334 (9%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
++PLH AA G +V+ LL+ A + GG LH AC+ GH V +LL GADPN
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGA-----RVDGRSEEEEETPLHVAARLGHVEL 275
D PLH G ++ +LL+ GA DG+S + P A G +
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329
+LL + N E LL +V C + ++T +++ LLL G
Sbjct: 337 DELL----EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392
Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
AD A D+ PLH AC GH V ELLL G N MD TPLH A ++
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH-------EAASK 445
Query: 390 SPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVL---MNTYSVVQLPEEAVGLVT 446
+ V LL+HGA K + P E L +S++Q EA
Sbjct: 446 NRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREA----- 500
Query: 447 PETLQKHQRFYSSLFALVRQPRSLQHLSRCALRS 480
L K ++ + +QP+S + CA+ S
Sbjct: 501 --DLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
Score = 92.0 bits (227), Expect = 1e-18
Identities = 76/252 (30%), Positives = 103/252 (40%), Gaps = 19/252 (7%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
+TPLH AA V+ LL A + GG LH AC+ GH +L+ GA N
Sbjct: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
+AD PLH G E +LLL+ GA + + TPL + G ++ DLL
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPT-KKNRDGNTPLDLVKE-GDTDIQDLLR 802
Query: 281 RRGACPDARNAEGWTPLLAAC---DVRCQSITDAEATTARC------LQLCSLLLSAGAD 331
A DA + C ++ C+ +T L++ LL GAD
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
+A D+ PLH A GH + LL+ N D TPLH A Q +
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQ-------KGR 915
Query: 392 EHVVRALLNHGA 403
+ LL HGA
Sbjct: 916 TQLCALLLAHGA 927
Score = 89.4 bits (220), Expect = 7e-18
Identities = 74/252 (29%), Positives = 107/252 (42%), Gaps = 40/252 (15%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
++ TPLHVAA R H +V+ +L + A+ ++ G+TALH A AGH +LL G+
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
DP+I G + E + +L E TP+ + D
Sbjct: 616 DPSIISLQGFTAAQMGN-----EAVQQIL------------SESTPIRTS---------D 649
Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAGAD 331
+ R A + E L ++ +V C+ + +T + + LL GAD
Sbjct: 650 VDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSP 391
A D+ PLH AC GH V ELL+ G S N D TPLH A A+
Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLH-------EAAAKGK 762
Query: 392 EHVVRALLNHGA 403
+ + LL HGA
Sbjct: 763 YEICKLLLKHGA 774
Score = 87.0 bits (214), Expect = 4e-17
Identities = 77/254 (30%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222
PLH A S GH EV LL+R A + A + T LHEA A G +LL GADP
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261
++DG PL L + G + +LL A +D ++
Sbjct: 780 NRDGNTPLDLVK-EGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS 838
Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321
TPLH+AA ++E+A+ LL GA +A++ G PL A + + +
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL-------------HNAASYGHVDI 885
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
+LL+ +A D+ PLH A ++G + LLL+ G + G TPL A
Sbjct: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Query: 382 GPAAAL---AQSPE 392
AL A PE
Sbjct: 946 DDIRALLIDAMPPE 959
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/128 (34%), Positives = 57/128 (44%), Gaps = 13/128 (10%)
Query: 260 EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL 319
+ +PLH AA G ++ + LL+ GA AR+ G PL AC S AE
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC-----SFGHAE------- 263
Query: 320 QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
+ SLLL GAD +A D PLH A +G V +LL G N + G + L A
Sbjct: 264 -VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322
Query: 380 LQGPAAAL 387
A L
Sbjct: 323 DPSAKAVL 330
Score = 36.2 bits (82), Expect = 0.073
Identities = 32/99 (32%), Positives = 39/99 (39%), Gaps = 14/99 (14%)
Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
L+ +A +A K PLH A G VVE LL G + + D GG PLH A
Sbjct: 201 LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260
Query: 384 AAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP 422
A VV LL GA P + W+ P
Sbjct: 261 HA-------EVVSLLLCQGAD-------PNARDNWNYTP 285
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 110 bits (274), Expect = 4e-24
Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL AA+ GH ++++LLL +A ++ G TAL ACA G+ V VLL +GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+++G PL G +E A LLL GA ++ S E +E+ L +A GH+E+ LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA + + E T L+ AC D AR LLL +GA + +
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL LA GH + LL+ G S ++ G+TPL A + E +V LL
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522
Query: 402 GA 403
GA
Sbjct: 523 GA 524
Score = 93.2 bits (230), Expect = 5e-19
Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217
+E+ T L A GH EV RLLL A+ + A + L A GH +L+ GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
+ +G PL G E LLL GA ++ ++EE +ET L +A G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551
Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320
L++ GA P A EG L+ A +V + T A T C
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611
Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379
+ +LL AGAD + + + PL A R GH V+ L+S G + N T HT L A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
G A VV LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688
Score = 92.0 bits (227), Expect = 1e-18
Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)
Query: 195 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254
TAL ACA GH V LL GA D+ G PL L G + E+LL GA ++
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 255 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
+SE ++TPL +A G E+ +LLL RGA + RN +TPL + A
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 1191
Query: 315 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366
+ + + +LL+AGA+ ++ K PL LA GH A V+LLL G N
Sbjct: 1192 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Score = 89.7 bits (221), Expect = 6e-18
Identities = 102/298 (34%), Positives = 134/298 (44%), Gaps = 47/298 (15%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
+ +PL +AA GH E+ LL+ R A + G T L EA GH V +LL GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275
+ N ++ + L L G LE A+ L++ GA ++ G S TPL AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579
Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317
LL GA A A G T L AC DV Q+ D E + AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367
+C++ L+S GA+ + + L LAC GH AVVELLL+ G +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 368 M----DYGGHTPLHCALQGPAAALAQSPEHVVRAL------LNHGAVRVWPGALPKVL 415
M GGHT + C L L +P V L LN A RV ALP V+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR-APRVPVQALPMVV 756
Score = 89.7 bits (221), Expect = 6e-18
Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220
+PL +AA GHT ++LLL + ++ TAL AC G T V +LL A+
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279
+ G PL G E +LL GA V+ +T L +AA GH + +LL
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
+ RGA D RN +G TPL A + L + LL+ AGAD DAAD K
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1386
Query: 340 QRPLHLACRRGHAAVVELLL 359
PL A R+GH VV L+
Sbjct: 1387 ITPLMAAFRKGHVKVVRYLV 1406
Score = 88.2 bits (217), Expect = 2e-17
Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
E TPL +A S G EV+ LLL R A + T L A + G+ + +LL AG
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206
Query: 217 ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
A+ N + G PL L G +LLL G+ ++ + E T L +A G E
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266
Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318
+ LLL R A + R G TPL+ A DV + + T
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1326
Query: 319 L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
+ C LL+ GA D ++ PL LA GH VV+LL+ G + D
Sbjct: 1327 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1386
Query: 373 HTPLHCALQ 381
TPL A +
Sbjct: 1387 ITPLMAAFR 1395
Score = 81.6 bits (200), Expect = 2e-15
Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%)
Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176
+G A + T DPE + A + L+ + E+ L + S E
Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215
Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234
L R RA + G +L EAC+ G V LL+ G N ++G+ L L
Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275
Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294
G E A++LL A V+ R + + TPL AA GHV++ LLL A +A+++ G
Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335
Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334
T L AC DV SI D EA +A +++ LLL GA +
Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395
Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
+++ K+ L LAC +GH +V LL G HT L A
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448
Query: 394 VVRALLNHGA 403
V R LL+ GA
Sbjct: 449 VARLLLDSGA 458
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)
Query: 252 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311
+D ++E +T L +A GH EL LL RGA + R+ +G+TPL+
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 1122
Query: 312 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
A TA + + +LL GAD +A +++ K PL LAC G VVELLL+ G + +
Sbjct: 1123 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181
Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+TPL A G ++++ LLN GA
Sbjct: 1182 SDYTPLSLAASGGYV-------NIIKILLNAGA 1207
Score = 64.3 bits (155), Expect = 3e-10
Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219
TPL AAS G+ EV R+LL + A ++ P TAL A GH +L+ GA
Sbjct: 1287 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1346
Query: 220 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
++ ++ G PL L G L+ +LL++ GA VD ++ + TPL A R GHV++ L
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1405
Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
++ P + C +ITD E +C LC + D AA+ +K
Sbjct: 1406 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1454
Query: 340 QRPLHL 345
+ L
Sbjct: 1455 NASILL 1460
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 110 bits (274), Expect = 4e-24
Identities = 82/242 (33%), Positives = 116/242 (47%), Gaps = 21/242 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL AA+ GH ++++LLL +A ++ G TAL ACA G+ V VLL +GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
+++G PL G +E A LLL GA ++ S E +E+ L +A GH+E+ LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA + + E T L+ AC D AR LLL +GA + +
Sbjct: 423 AGADQEHKTDEMHTALMEAC-------MDGHVEVAR------LLLDSGAQVNMPADSFES 469
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL LA GH + LL+ G S ++ G+TPL A + E +V LL
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-------MEAAREGHEEMVALLLGQ 522
Query: 402 GA 403
GA
Sbjct: 523 GA 524
Score = 93.2 bits (230), Expect = 5e-19
Identities = 86/264 (32%), Positives = 116/264 (43%), Gaps = 26/264 (9%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDS-APGGRTALHEACAAGHTACVHVLLVAGA 217
+E+ T L A GH EV RLLL A+ + A + L A GH +L+ GA
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
+ +G PL G E LLL GA ++ ++EE +ET L +A G +E+AD
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551
Query: 278 LLLRRGA-------CPDARNA-EGWTPLL-----AACDVRCQSITDAEATTARC----LQ 320
L++ GA P A EG L+ A +V + T A T C
Sbjct: 552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTD 611
Query: 321 LCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN-TMDYGGHTPLHCA 379
+ +LL AGAD + + + PL A R GH V+ L+S G + N T HT L A
Sbjct: 612 VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 380 LQGPAAALAQSPEHVVRALLNHGA 403
G A VV LL HGA
Sbjct: 672 CAGGHLA-------VVELLLAHGA 688
Score = 92.0 bits (227), Expect = 1e-18
Identities = 63/174 (36%), Positives = 86/174 (49%), Gaps = 15/174 (8%)
Query: 195 TALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDG 254
TAL ACA GH V LL GA D+ G PL L G + E+LL GA ++
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 255 RSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
+SE ++TPL +A G E+ +LLL RGA + RN +TPL + A
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL-------------SLAA 940
Query: 315 TARCLQLCSLLLSAGADADAADQDKQ--RPLHLACRRGHAAVVELLLSCGVSAN 366
+ + + +LL+AGA+ ++ K PL LA GH A V+LLL G N
Sbjct: 941 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994
Score = 89.7 bits (221), Expect = 6e-18
Identities = 102/298 (34%), Positives = 134/298 (44%), Gaps = 47/298 (15%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
+ +PL +AA GH E+ LL+ R A + G T L EA GH V +LL GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 218 DPNIADQDGKRP-LHLCRGPGTLECAELLLRFGARVD-GRSEEEEETPLHVAARLGHVEL 275
+ N ++ + L L G LE A+ L++ GA ++ G S TPL AA+ GH+EL
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLEL 579
Query: 276 ADLLLRRGACPDARNAEGWTPLLAAC--------DVRCQSITDAEATT----------AR 317
LL GA A A G T L AC DV Q+ D E + AR
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 318 CLQLCSL--LLSAGADADAADQDKQRP-LHLACRRGHAAVVELLLSCGV-------SANT 367
+C++ L+S GA+ + + L LAC GH AVVELLL+ G +T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 368 M----DYGGHTPLHCALQGPAAALAQSPEHVVRAL------LNHGAVRVWPGALPKVL 415
M GGHT + C L L +P V L LN A RV ALP V+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNR-APRVPVQALPMVV 756
Score = 89.7 bits (221), Expect = 6e-18
Identities = 71/200 (35%), Positives = 94/200 (47%), Gaps = 16/200 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA--PGGRTALHEACAAGHTACVHVLLVAGADPN 220
+PL +AA GHT ++LLL + ++ TAL AC G T V +LL A+
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS-EEEEETPLHVAARLGHVELADLL 279
+ G PL G E +LL GA V+ +T L +AA GH + +LL
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
+ RGA D RN +G TPL A + L + LL+ AGAD DAAD K
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAAN-------------GGHLDVVQLLVQAGADVDAADNRK 1135
Query: 340 QRPLHLACRRGHAAVVELLL 359
PL A R+GH VV L+
Sbjct: 1136 ITPLMAAFRKGHVKVVRYLV 1155
Score = 88.2 bits (217), Expect = 2e-17
Identities = 75/249 (30%), Positives = 103/249 (41%), Gaps = 25/249 (10%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
E TPL +A S G EV+ LLL R A + T L A + G+ + +LL AG
Sbjct: 896 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955
Query: 217 ADPN--IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
A+ N + G PL L G +LLL G+ ++ + E T L +A G E
Sbjct: 956 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015
Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC----------------DVRCQSITDAEATTARC 318
+ LLL R A + R G TPL+ A DV + + T
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1075
Query: 319 L------QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
+ C LL+ GA D ++ PL LA GH VV+LL+ G + D
Sbjct: 1076 AADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRK 1135
Query: 373 HTPLHCALQ 381
TPL A +
Sbjct: 1136 ITPLMAAFR 1144
Score = 81.6 bits (200), Expect = 2e-15
Identities = 90/310 (29%), Positives = 128/310 (41%), Gaps = 37/310 (11%)
Query: 124 TGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEE-------ELTTPLHVAASRGHTEV 176
+G A + T DPE + A + L+ + E+ L + S E
Sbjct: 156 SGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEA 215
Query: 177 LRLLLRRRARPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCR 234
L R RA + G +L EAC+ G V LL+ G N ++G+ L L
Sbjct: 216 AAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLAC 275
Query: 235 GPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGW 294
G E A++LL A V+ R + + TPL AA GHV++ LLL A +A+++ G
Sbjct: 276 SAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335
Query: 295 TPLLAAC-----DV------RCQSITD---------AEATTARCLQLCSLLLSAGADADA 334
T L AC DV SI D EA +A +++ LLL GA +
Sbjct: 336 TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINT 395
Query: 335 -ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEH 393
+++ K+ L LAC +GH +V LL G HT L A
Sbjct: 396 HSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL-------MEACMDGHVE 448
Query: 394 VVRALLNHGA 403
V R LL+ GA
Sbjct: 449 VARLLLDSGA 458
Score = 76.3 bits (186), Expect = 6e-14
Identities = 52/153 (33%), Positives = 77/153 (50%), Gaps = 21/153 (13%)
Query: 252 VDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA 311
+D ++E +T L +A GH EL LL RGA + R+ +G+TPL+
Sbjct: 824 IDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL------------ 871
Query: 312 EATTARCLQLCSLLLSAGADADA-ADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
A TA + + +LL GAD +A +++ K PL LAC G VVELLL+ G + +
Sbjct: 872 -AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
+TPL A G ++++ LLN GA
Sbjct: 931 SDYTPLSLAASGGYV-------NIIKILLNAGA 956
Score = 64.3 bits (155), Expect = 3e-10
Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 15/186 (8%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP---GGRTALHEACAAGHTACVHVLLVAGADP 219
TPL AAS G+ EV R+LL + A ++ P TAL A GH +L+ GA
Sbjct: 1036 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI 1095
Query: 220 NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLL 279
++ ++ G PL L G L+ +LL++ GA VD ++ + TPL A R GHV++ L
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDA-ADNRKITPLMAAFRKGHVKVVRYL 1154
Query: 280 LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
++ P + C +ITD E +C LC + D AA+ +K
Sbjct: 1155 VKE---------VNQFPSDSECMRYIATITDKE-MLKKC-HLCMESIVQAKDRQAAEANK 1203
Query: 340 QRPLHL 345
+ L
Sbjct: 1204 NASILL 1209
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 109 bits (273), Expect = 5e-24
Identities = 84/254 (33%), Positives = 115/254 (45%), Gaps = 23/254 (9%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPN 220
+TPLH AA G +V+ LL+ A + GG LH AC+ GH V++LL GADPN
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGAR-----VDGRSEEEEETPLHVAARLGHVEL 275
D PLH G ++ +LL+ GA DGR+ + P A G +
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178
Query: 276 ADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC------LQLCSLLLSAG 329
+LL + N E LL +V C + ++T +++ LLL G
Sbjct: 179 DELL----ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234
Query: 330 ADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQ 389
AD A D+ PLH AC GH V ELL+ G N MD TPLH A ++
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH-------EAASK 287
Query: 390 SPEHVVRALLNHGA 403
+ V LL++GA
Sbjct: 288 NRVEVCSLLLSYGA 301
Score = 95.1 bits (235), Expect = 1e-19
Identities = 79/248 (31%), Positives = 111/248 (44%), Gaps = 32/248 (12%)
Query: 159 EELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
+E TPLHVA+ + H +V+ ++++ A+ ++ G+T+LH A GH +LL G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
DPNI G L + E + LL+ G + G SE + + L AA+ G VE
Sbjct: 458 DPNIISLQGFTALQMGN-----ENVQQLLQEGISL-GNSEADRQ--LLEAAKAGDVETVK 509
Query: 278 LL--LRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAA 335
L ++ C D + TPL A S+ + LL GAD A
Sbjct: 510 KLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVE-------------YLLQHGADVHAK 555
Query: 336 DQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVV 395
D+ PLH AC GH V ELL+ G N D TPLH A A+ +
Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLH-------EAAAKGKYEIC 608
Query: 396 RALLNHGA 403
+ LL HGA
Sbjct: 609 KLLLQHGA 616
Score = 90.1 bits (222), Expect = 4e-18
Identities = 80/256 (31%), Positives = 108/256 (42%), Gaps = 19/256 (7%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAG 216
E +TPLH AA V+ LL+ A + GG LH AC+ GH +L+ G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
A N+AD PLH G E +LLL+ GA + + TPL + + G ++
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT-KKNRDGNTPLDLV-KDGDTDIQ 640
Query: 277 DLLLRRGACPDA--RNAEGWTPLLAACD-VRCQSITDAEATTARC------LQLCSLLLS 327
DLL A DA + L++ D V C+ +T L++ LL
Sbjct: 641 DLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQ 700
Query: 328 AGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAAL 387
GAD +A D+ PLH A GH V LL+ N D TPLH A Q
Sbjct: 701 HGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ------ 754
Query: 388 AQSPEHVVRALLNHGA 403
+ + LL HGA
Sbjct: 755 -KGRTQLCALLLAHGA 769
Score = 85.5 bits (210), Expect = 1e-16
Identities = 73/246 (29%), Positives = 108/246 (43%), Gaps = 36/246 (14%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPNIA 222
PLH A S GH EV LL++ A + A + T LHEA A G +LL GADP
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK 621
Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGR---------------------SEEEEE 261
++DG PL L + G + +LL A +D ++
Sbjct: 622 NRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHS 680
Query: 262 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 321
TPLH+AA ++E+A+ LL+ GA +A++ G PL A + + +
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPL-------------HNAASYGHVDV 727
Query: 322 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
+LL+ A +A D+ PLH A ++G + LLL+ G + G TPL
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Query: 382 GPAAAL 387
+AL
Sbjct: 788 DDVSAL 793
Score = 72.0 bits (175), Expect = 1e-12
Identities = 75/270 (27%), Positives = 105/270 (38%), Gaps = 46/270 (17%)
Query: 155 LTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLL 213
LT E + L A S +++ LL ++ G + T LH A V +LL
Sbjct: 172 LTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLL 231
Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV 273
GAD + D+ PLH G E ELL++ GA V+ + + TPLH AA V
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM-DLWQFTPLHEAASKNRV 290
Query: 274 ELADLLLRRGACPDARNA----------------------EGWTPLLAACDVRCQSI--- 308
E+ LLL GA P N +G + L AA + I
Sbjct: 291 EVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKH 350
Query: 309 ----------TDAEATTARCL---------QLCSLLLSAGADADAADQDKQRPLHLACRR 349
T C Q+C LLL GA+ + ++ PLH+A +
Sbjct: 351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEK 410
Query: 350 GHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
H VVE+++ N +D G T LH A
Sbjct: 411 AHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Score = 72.0 bits (175), Expect = 1e-12
Identities = 72/244 (29%), Positives = 99/244 (40%), Gaps = 61/244 (25%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARP--------------------------------DSA 190
TPLH AA++G E+ +LLL+ A P D+A
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA 653
Query: 191 PGG-----------------------RTALHEACAAGHTACVHVLLVAGADPNIADQDGK 227
G T LH A + LL GAD N D+ G
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
Query: 228 RPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPD 287
PLH G ++ A LL+++ A V+ +++ TPLH AA+ G +L LLL GA P
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772
Query: 288 ARNAEGWTPL-LAACDVRCQSITDAEATTA--RCL--QLCSLLLSAGADADAADQDKQRP 342
+N EG TPL L + D +T A +A C Q+ + + S GA ADA P
Sbjct: 773 LKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSP 832
Query: 343 LHLA 346
L+
Sbjct: 833 SSLS 836
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 108 bits (271), Expect = 9e-24
Identities = 76/219 (34%), Positives = 108/219 (49%), Gaps = 15/219 (6%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPN 220
T PL +AA G+ ++L+LL++R +R D GG A++ A GH + L +
Sbjct: 380 TPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLD 439
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
+ D+ G+ LH+ G + A+LL FG+ ++EEETPLH AA G+ +A L
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSN-PNIQDKEEETPLHCAAWHGYYSVAKALC 498
Query: 281 RRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQ 340
G + +N EG TPLL A I + L GAD +A D+D
Sbjct: 499 EAGCNVNIKNREGETPLLTASARGYHDIVEC-------------LAEHGADLNACDKDGH 545
Query: 341 RPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
LHLA RR V++ LLS G + D G+TPLH A
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Score = 91.3 bits (225), Expect = 2e-18
Identities = 65/213 (30%), Positives = 97/213 (45%), Gaps = 15/213 (7%)
Query: 168 AASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDG 226
AA GH + L+ L + D G ALH A GH +L G++PNI D++
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478
Query: 227 KRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACP 286
+ PLH G A+ L G V+ ++ E ETPL A+ G+ ++ + L GA
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKN-REGETPLLTASARGYHDIVECLAEHGADL 537
Query: 287 DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLA 346
+A + +G L A RCQ +++ LLS G D D+ PLH+A
Sbjct: 538 NACDKDGHIALHLAVR-RCQ------------MEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Query: 347 CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
C+ G+ +V L + + + G TPLH A
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/202 (30%), Positives = 80/202 (39%), Gaps = 15/202 (7%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAG 216
++E TPLH AA G+ V + L + G T L A A G+ V L G
Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534
Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
AD N D+DG LHL +E + LL G VD + + TPLHVA + G++ +
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIV 593
Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
L D N G TPL A + L + L GA +A
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAAN-------------NGILDVVRYLCLMGASVEALT 640
Query: 337 QDKQRPLHLACRRGHAAVVELL 358
D + LA H V LL
Sbjct: 641 TDGKTAEDLARSEQHEHVAGLL 662
Score = 50.8 bits (120), Expect = 3e-06
Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 9/118 (7%)
Query: 165 LHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIAD 223
LH+A R EV++ LL + D G T LH AC G+ V L A + +I++
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607
Query: 224 QDGKRPLHLCRGPGTLECAELLLRFGARV-----DGRSEEE---EETPLHVAARLGHV 273
+ G+ PLHL G L+ L GA V DG++ E+ E HVA L +
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARL 665
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 107 bits (266), Expect = 3e-23
Identities = 84/269 (31%), Positives = 122/269 (45%), Gaps = 28/269 (10%)
Query: 156 TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLV 214
T + E TPLHVAA G E++ LL+ AR ++ T LH A A+ V VL+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70
Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
AD N D++ + PLH+ ++CAE+++ + V+ S+ T LH AA GHVE
Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVE 129
Query: 275 LADLLLRRGACPDA-----RNAEGWTPLLAACDVRCQSITDAEATTARC----------- 318
+ +LLL +GA +A R A W + DV I T +
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 319 ----LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374
+ + LL+ G + D + LH+AC G AVV L+ G + N + G T
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403
PLH A AL + L+N+GA
Sbjct: 250 PLHFAAASTHGALC------LELLVNNGA 272
Score = 99.4 bits (246), Expect = 7e-21
Identities = 79/242 (32%), Positives = 113/242 (46%), Gaps = 29/242 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLHVAA+ + +++ + + S GGRTALH A GH V++LL GA+ N
Sbjct: 84 TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
D+ +R LH G L+ LL+ GA V + +++ TPLH AA G + + LL
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK-DKKGYTPLHAAASNGQINVVKHLLN 202
Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317
G D N G T L AC D + D A A+T A
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
CL+ LL++ GAD + +D + PLH+ G + L+ G + +D G+TPLH
Sbjct: 263 CLE---LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH 319
Query: 378 CA 379
A
Sbjct: 320 VA 321
Score = 94.4 bits (233), Expect = 2e-19
Identities = 93/297 (31%), Positives = 129/297 (43%), Gaps = 32/297 (10%)
Query: 98 GPALAFWQAVLAGDVGCVSRILADSSTGLAPDSVFDTSDPE--RWRDFRFNIRALRLWSL 155
G A A L G V V+ +LA A + FD D W + ++ + L +
Sbjct: 114 GGRTALHHAALNGHVEMVNLLLAKG----ANINAFDKKDRRALHWAAYMGHLDVVALL-I 168
Query: 156 TYEEELT-------TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTA 207
+ E+T TPLH AAS G V++ LL D G TALH AC G A
Sbjct: 169 NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDA 228
Query: 208 CVHVLLVAGADPNIADQDGKRPLHLCRGP--GTLECAELLLRFGARVDGRSEEEEETPLH 265
V+ L+ GA+ N + +G PLH G L C ELL+ GA V+ +S++ + +PLH
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGK-SPLH 286
Query: 266 VAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
+ A G + L++ G D + +G TPL A + L + L
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL-------------LINTL 333
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
++GAD PLHLA H+ LLS G +T D G T LH A G
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390
Score = 91.7 bits (226), Expect = 1e-18
Identities = 77/239 (32%), Positives = 106/239 (44%), Gaps = 20/239 (8%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRAR--PDSAPGG-RTALHEACAAGHTACVHVLLV 214
++E +H AA+ GH + L LLL R +S G ++ LH A GH + VLL
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
+ D +I D+ G+ L L G EC E L+ GA + + + TPLH + GH
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623
Query: 275 LADLLLRRGACP---DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGAD 331
LLL P D ++A+G TPL+ A + SLLL A+
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLML-------------AVAYGHIDAVSLLLEKEAN 670
Query: 332 ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH-CALQGPAAALAQ 389
D D LH GH V++LL VS D G TPLH A +G A L++
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
Score = 81.3 bits (199), Expect = 2e-15
Identities = 66/205 (32%), Positives = 97/205 (47%), Gaps = 28/205 (13%)
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
D N D + + PLH+ G E ELL+ GARV+ + + TPLH A E
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAVASRSEEAVQ 66
Query: 278 LLLRRGACPDARNAEGWTPLLAAC---DVRCQ----------SITDAEATTA-------R 317
+L++ A +AR+ TPL A V+C +++D TA
Sbjct: 67 VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG 126
Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
+++ +LLL+ GA+ +A D+ +R LH A GH VV LL++ G D G+TPLH
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186
Query: 378 CALQGPAAALAQSPEHVVRALLNHG 402
AA + +VV+ LLN G
Sbjct: 187 -------AAASNGQINVVKHLLNLG 204
Score = 80.5 bits (197), Expect = 3e-15
Identities = 77/269 (28%), Positives = 110/269 (40%), Gaps = 48/269 (17%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222
PLH+AA H++ R LL D+ GRT LH A A G+ C+ +L +GAD +
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAAR---------LGHV 273
D+ G+ PLH C E L+ GA V+ +++ T LH AA LG+
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNA 468
Query: 274 E-------------------LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEAT 314
+ LL+ A P R+ EG+ + A A
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA----------AAYG 518
Query: 315 TARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 374
+CL+L ++G + + K PLHLA GH +E+LL V + D G T
Sbjct: 519 HRQCLELLLERTNSGFEESDSGATKS-PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577
Query: 375 PLHCALQGPAAALAQSPEHVVRALLNHGA 403
L A + V AL+N GA
Sbjct: 578 ALD-------LAAFKGHTECVEALINPGA 599
Score = 79.3 bits (194), Expect = 8e-15
Identities = 69/202 (34%), Positives = 90/202 (44%), Gaps = 18/202 (8%)
Query: 163 TPLHVAASRGH----TEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGAD 218
TPLH AA+RGH +E+L++ L G T LH AC G+ C+ VLL
Sbjct: 713 TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF 772
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELAD 277
PLH CA LLL + + +++ TPL AA HVE
Sbjct: 773 RKFIGNPFT-PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831
Query: 278 LLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337
LLLR A +A + G T L+ A AE A + + L+ SA AD D+
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMA----------AENGQAGAVDI--LVNSAQADLTVKDK 879
Query: 338 DKQRPLHLACRRGHAAVVELLL 359
D PLHLAC +GH L+L
Sbjct: 880 DLNTPLHLACSKGHEKCALLIL 901
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/255 (30%), Positives = 104/255 (40%), Gaps = 32/255 (12%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP----GGRTALHEACAAGHTACVHVLLVAGAD 218
TPLH + GHT LRLLL P++ G+T L A A GH V +LL A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHV----E 274
+ D G LH G EC ++LL + + + TPLH AA GH E
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSE 729
Query: 275 LADLLLRRGACPDARNAEGWTPLLAAC------------DVRC-QSITDAEATTARCLQL 321
L + L C N +G+TPL AC + +C + T C +
Sbjct: 730 LLQMALSEEDCCFKDN-QGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAII 788
Query: 322 -----CSLLLSAGADADAAD--QDKQR-PLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373
C+ LL D+ DK R PL A H ++LLL N +D G
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
Query: 374 TPLHCALQ-GPAAAL 387
T L A + G A A+
Sbjct: 849 TALMMAAENGQAGAV 863
Score = 48.1 bits (113), Expect = 2e-05
Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 324 LLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGP 383
+L+ D + D +K+ PLH+A G A ++ELL+ G N D TPLH
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH------ 54
Query: 384 AAALAQSPEHVVRALLNHGA 403
A+A E V+ L+ H A
Sbjct: 55 -RAVASRSEEAVQVLIKHSA 73
Score = 29.3 bits (64), Expect = 8.9
Identities = 11/24 (45%), Positives = 18/24 (75%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLL 181
+++L TPLH+A S+GH + L+L
Sbjct: 878 DKDLNTPLHLACSKGHEKCALLIL 901
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 105 bits (262), Expect = 1e-22
Identities = 84/242 (34%), Positives = 113/242 (46%), Gaps = 17/242 (7%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL +AA +GHT+V+ L+ A + G TAL A GHT V LL AG +
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
AD D + L G + LL+ GA V+ +++ E T L AA +GH E+ + LL
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVN-KADNEGRTALIAAAYMGHREIVEHLLD 698
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
GA + + +G T L A C + A+ SLL+ GA+ D D+D
Sbjct: 699 HGAEVNHEDVDGRTALSVAA--LCVPASKGHASVV------SLLIDRGAEVDHCDKDGMT 750
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNH 401
PL +A GH VV+LLL G + D G TPL AA + VV LL
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL-------LAAASMGHASVVNTLLFW 803
Query: 402 GA 403
GA
Sbjct: 804 GA 805
Score = 105 bits (261), Expect = 1e-22
Identities = 90/246 (36%), Positives = 112/246 (45%), Gaps = 27/246 (10%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
T L AA GHTEV+ LL + D A RTAL A GH V LL GA+ N
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL-----GHVELA 276
AD +G+ L G E E LL GA V+ + + T L VAA GH +
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVV 731
Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
LL+ RGA D + +G TPLL A + D LLL GAD D D
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD-------------LLLEGGADVDHTD 778
Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
+ + PL A GHA+VV LL G + +++D G T L + A AQ VVR
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL-------SIASAQGNVEVVR 831
Query: 397 ALLNHG 402
LL+ G
Sbjct: 832 TLLDRG 837
Score = 96.7 bits (239), Expect = 5e-20
Identities = 75/262 (28%), Positives = 119/262 (45%), Gaps = 25/262 (9%)
Query: 147 IRALRLWSL---TYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACA 202
+ L W + + E T L +A+++G+ EV+R LL R + G T LH A
Sbjct: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856
Query: 203 AGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEET 262
GH L+ GA N D DG+ P L G +C ++LL + +D R +
Sbjct: 857 EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916
Query: 263 PLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLC 322
L VAA GH ++ +LL GA + ++A+G P L + Q L +
Sbjct: 917 -LRVAALEGHRDIVELLFSHGADVNCKDADG-RPTLYILALENQ------------LTMA 962
Query: 323 SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
L GA+ +A+D + + LH++C +GH +V++L++ N D + L
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ----- 1017
Query: 383 PAAALAQSPEHVVRALLNHGAV 404
+A Q VV+ L+ HGAV
Sbjct: 1018 --SAAWQGHVKVVQLLIEHGAV 1037
Score = 89.4 bits (220), Expect = 7e-18
Identities = 69/216 (31%), Positives = 101/216 (46%), Gaps = 15/216 (6%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNI 221
TPL VAA GH +V+ LLL A D GRT L A + GH + V+ LL GA +
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
D +G+ L + G +E LL G + R ++ TPLH+AA GH + + L+
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR-DDAGWTPLHMAAFEGHRLICEALIE 868
Query: 282 RGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR 341
+GA + + +G P + A ++ C+Q +LL ++ D D +
Sbjct: 869 QGARTNEIDNDGRIPFILA----------SQEGHYDCVQ---ILLENKSNIDQRGYDGRN 915
Query: 342 PLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
L +A GH +VELL S G N D G L+
Sbjct: 916 ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLY 951
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/246 (28%), Positives = 117/246 (47%), Gaps = 24/246 (9%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIA 222
P +A+ GH + +++LL ++ D GR AL A GH V +L GAD N
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRR 282
D DG+ L++ L AE L GA V+ S+ E T LHV+ GH+E+ +L+
Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEA-SDAEGRTALHVSCWQGHMEMVQVLIAY 1001
Query: 283 GACPDARNAEGWTPLLAAC---DVRCQSI----------TDAEATTARC-------LQLC 322
A +A + E + L +A V+ + T + TA C + +
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
Query: 323 SLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
+LL GAD + ADQ + + +A + GH+ +++LL G A++++ +P+H Q
Sbjct: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119
Query: 383 PAAALA 388
P +L+
Sbjct: 1120 PLQSLS 1125
Score = 60.8 bits (146), Expect = 3e-09
Identities = 47/147 (31%), Positives = 65/147 (44%), Gaps = 16/147 (10%)
Query: 236 PGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWT 295
P E +LL++ GA V+ E++ T V L + LL GA + ++ G T
Sbjct: 491 PKEQEVLQLLVKAGAHVNS---EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRT 547
Query: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVV 355
L A A + L + +LL+S GAD + D PL LA R+GH VV
Sbjct: 548 LL-------------ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
Query: 356 ELLLSCGVSANTMDYGGHTPLHCALQG 382
L+ CG + N D G T L A G
Sbjct: 595 NCLIGCGANINHTDQDGWTALRSAAWG 621
Score = 37.7 bits (86), Expect = 0.025
Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 1/56 (1%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGA 217
T L +AA GH +V+++LL A P+ A GRTA+ A GH+ + +L GA
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 104 bits (260), Expect = 2e-22
Identities = 81/241 (33%), Positives = 113/241 (46%), Gaps = 21/241 (8%)
Query: 149 ALRLWSLTYEEELTTPLHVAASRGHT-EVLRLLLRRRARPDSAPG-GRTALHEACAAGHT 206
A+ W+ ++++L +H RG V L R+ ARP G++ H A + G T
Sbjct: 13 AVERWN-RHDQKLLEAVH----RGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLT 67
Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
C+ +LL GAD N ++DG LHL +C ++LL+ GA D + E +PLH
Sbjct: 68 ECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDA-VDAENRSPLHW 126
Query: 267 AARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLL 326
AA G LL A D + +G TPL+ A + +CS LL
Sbjct: 127 AASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIA-------------SLGGHAAICSQLL 173
Query: 327 SAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAA 386
GA + D++ + L LAC +G A V ELLLS G A +D GH LH AL A
Sbjct: 174 QRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKA 233
Query: 387 L 387
L
Sbjct: 234 L 234
Score = 75.1 bits (183), Expect = 1e-13
Identities = 59/187 (31%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
A P D +G+ P HL G EC +LL GA ++ ++E+ T LH+A +
Sbjct: 45 ARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGS-TALHLATISCQPQCV 103
Query: 277 DLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAAD 336
+LL+ GA DA +AE +PL A C S LL A D D
Sbjct: 104 KVLLQHGANEDAVDAENRSPLHWAASSGCASSV-------------LLLCDHEAFLDVLD 150
Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVR 396
D + PL +A GHAA+ LL G N D + L A + +A +A+
Sbjct: 151 NDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAE------- 203
Query: 397 ALLNHGA 403
LL+HGA
Sbjct: 204 LLLSHGA 210
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 103 bits (258), Expect = 3e-22
Identities = 82/251 (32%), Positives = 112/251 (44%), Gaps = 22/251 (8%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGG-RTALHEACAAGHTACVHVLLVAG 216
+ E TPLH AA G E++ LL+ AR ++ T LH A A+ V VLL
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97
Query: 217 ADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELA 276
AD N D++ + PLH+ ++CAE L+ + V+ S+ T LH AA GH E+
Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV-SDRAGRTALHHAAFSGHGEMV 156
Query: 277 DLLLRRGACPDA-----RNAEGWTPLLA-----------ACDVRCQ---SITDAEATTAR 317
LLL RGA +A R A W + +V C+ S T A +
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Query: 318 -CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPL 376
+ + LL G D + + PLH+AC G VV L+ CG N + G TPL
Sbjct: 217 GMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Query: 377 HCALQGPAAAL 387
H A AL
Sbjct: 277 HFAAASTHGAL 287
Score = 100 bits (250), Expect = 2e-21
Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 29/242 (11%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
TPLH+AA+ + L+ + + S GRTALH A +GH V +LL GA+ N
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA 168
Query: 222 ADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLR 281
D+ +R +H G +E +LL+ GA V + +++ TPLH AA G + + LL
Sbjct: 169 FDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK-DKKSYTPLHAAASSGMISVVKYLLD 227
Query: 282 RGACPDARNAEGWTPLLAAC----DVRCQSITD------------------AEATT--AR 317
G + NA G TPL AC DV + D A A+T A
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 318 CLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLH 377
CL+ LL+ GAD + +D + PLH+ G + + ++ G + D G+TPLH
Sbjct: 288 CLE---LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH 344
Query: 378 CA 379
A
Sbjct: 345 IA 346
Score = 98.6 bits (244), Expect = 1e-20
Identities = 81/255 (31%), Positives = 114/255 (44%), Gaps = 44/255 (17%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAP-----GGRTALHEACAAGHTACVHVLLVAGA 217
TP+H AA+ GH+E LRLL+ A P +A G+T L + GHT CV+ LL GA
Sbjct: 619 TPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD 277
+ + D+ G+ LH G EC + LL+ GA+ R + TP+H++A GH+ +
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR-DSRGRTPIHLSAACGHIGVLG 736
Query: 278 LLLRRGACPDARNA----EGWTPLLAAC--------------------------DVRCQS 307
LL+ A DA A G+T L AC + C
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796
Query: 308 ITDAEATTARCLQLCSLLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSAN 366
I D E L+ + GA +A D + PLH A H ++LLLS N
Sbjct: 797 INDNEGAAE------MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 367 TMDYGGHTPLHCALQ 381
++D G TPL A +
Sbjct: 851 SVDSTGKTPLMMAAE 865
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/248 (32%), Positives = 112/248 (45%), Gaps = 32/248 (12%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPG-----GRTALHEACAAGHTACVHVLLVAGA 217
TP+H++A+ GH VL LL+ A D+ P G TALH AC GH CV +LL
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 218 DPNIADQDGKRPLHLCRGPGTLECAELLL-RFGARVDGRSEEEEETPLHVAARLGHVELA 276
+ + PLH AE+L+ GA + ++ + TPLH AA HVE
Sbjct: 781 FQK-TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839
Query: 277 DLLLRRGACPDARNAEGWTPLLAACD---VRCQSITDAEATTARCLQ----------LCS 323
LLL A ++ ++ G TPL+ A + + + A+ LQ CS
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899
Query: 324 --------LLLSAGADAD---AADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGG 372
L+L D + A + Q PLH+A R G VV+ LL G S +D G
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959
Query: 373 HTP-LHCA 379
+TP L CA
Sbjct: 960 YTPALACA 967
Score = 86.7 bits (213), Expect = 5e-17
Identities = 81/249 (32%), Positives = 117/249 (46%), Gaps = 25/249 (10%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAPG-GRTALHEACAAGHTACVHVLLVAGADPNIA 222
PLH+AA G ++ R LL D+ GRT LH A A G+ C+++LL GAD N
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 223 DQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLG-HVELADLLLR 281
D+ G+ PLH +C L+ GA V+ +E TPLH AA + + LLR
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVND-LDERGCTPLHYAATSDTDGKCLEYLLR 493
Query: 282 RGACPDARNAEGWTPL--LAACDVR-CQSITDAEATTARCLQLCSLLLSAGAD--ADAAD 336
A P R+ +G+ + AA R C + +E L L+ ++G D +D+ +
Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASET------PLDVLMETSGTDMLSDSDN 547
Query: 337 QDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHV-- 394
+ PLHLA GH +E+L+ + + + G TPL LA HV
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLD---------LAAFKGHVEC 598
Query: 395 VRALLNHGA 403
V L+N GA
Sbjct: 599 VDVLINQGA 607
Score = 85.1 bits (209), Expect = 1e-16
Identities = 83/262 (31%), Positives = 107/262 (40%), Gaps = 61/262 (23%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHV---------- 211
+PLH+AA GH + L +L++ D GRT L A GH CV V
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 212 -----------------------LLVAGADP----NIADQDGKRPLHLCRGPGTLECAEL 244
LL+ A+P +I D +G+ PL L G +C
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 245 LLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTP--LLAACD 302
LL GA VD + ++ T LH A GH E D LL+ GA R++ G TP L AAC
Sbjct: 672 LLNKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 303 VRCQSITDAEATTARCLQLCSLLLSAGADADA----ADQDKQRPLHLACRRGHAAVVELL 358
+ + LL + A DA AD LH AC GH VELL
Sbjct: 731 ---------------HIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 359 LSCGVSANTMDYGGHTPLHCAL 380
L V T + +PLHCA+
Sbjct: 776 LEQEVFQKT-EGNAFSPLHCAV 796
Score = 82.0 bits (201), Expect = 1e-15
Identities = 68/219 (31%), Positives = 103/219 (47%), Gaps = 25/219 (11%)
Query: 194 RTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVD 253
RT LH A G + +L+++GA N D PLH + E ++LL+ A V+
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDA-- 311
R ++ +TPLH+AA V+ A+ L+ PLL+ +V ++ A
Sbjct: 102 AR-DKNWQTPLHIAAANKAVKCAEALV---------------PLLSNVNVSDRAGRTALH 145
Query: 312 EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG 371
A + ++ LLLS GA+ +A D+ +R +H A GH VV+LL+S G D
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Query: 372 GHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGA 410
+TPLH AA + VV+ LL+ G P A
Sbjct: 206 SYTPLH-------AAASSGMISVVKYLLDLGVDMNEPNA 237
Score = 78.6 bits (192), Expect = 1e-14
Identities = 61/201 (30%), Positives = 88/201 (43%), Gaps = 20/201 (9%)
Query: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
LH A GH + VL+ + D ++ + G+ PL L G +EC ++L+ GA + +
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 257 EEEEETPLHVAARLGHVELADLLLRRGA---CPDARNAEGWTPLLAACDVRCQSITDAEA 313
+ TP+H AA GH E LL+ D ++ G TPL+ + TD
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV---LNGHTDCVY 670
Query: 314 TTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH 373
+ LL+ GA+ DA D+ + LH GH V+ LL G D G
Sbjct: 671 S----------LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 374 TPLH----CALQGPAAALAQS 390
TP+H C G AL QS
Sbjct: 721 TPIHLSAACGHIGVLGALLQS 741
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 7/73 (9%)
Query: 331 DADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQS 390
D + D +K+ PLH A G A ++ELL+ G N D TPLH A+A
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLH-------RAVASC 85
Query: 391 PEHVVRALLNHGA 403
E V+ LL H A
Sbjct: 86 SEEAVQVLLKHSA 98
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 103 bits (257), Expect = 4e-22
Identities = 75/212 (35%), Positives = 108/212 (50%), Gaps = 14/212 (6%)
Query: 191 PGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 250
P G +ALH A G+T + +LL A A +I D G RPLH G E +L+L+ G+
Sbjct: 47 PDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGS 106
Query: 251 RVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITD 310
V+ S +E PLH+AA+ GH +++++LL+ + P + G TPL AC+ +
Sbjct: 107 AVNIPS-DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQ 165
Query: 311 AEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDY 370
++ +C+ LL DA D + PLHLA + GH ++ LLL G+ N
Sbjct: 166 LLLSS----NMCAALLEP-RPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
Query: 371 GGHTPLHCALQGPAAALAQSPEHVVRALLNHG 402
G T LH AAL E VVR LL+ G
Sbjct: 221 SG-TALH------EAALCGKTE-VVRLLLDSG 244
Score = 65.9 bits (159), Expect = 9e-11
Identities = 49/143 (34%), Positives = 67/143 (46%), Gaps = 11/143 (7%)
Query: 164 PLHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLL-----VAGA 217
PLH+AA GH +V +LL+ ++ P G+T L AC G V +LL A
Sbjct: 118 PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALL 177
Query: 218 DP---NIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 274
+P + D +G PLHL G ++ LLL+ G +D + + T LH AA G E
Sbjct: 178 EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG--IDINRQTKSGTALHEAALCGKTE 235
Query: 275 LADLLLRRGACPDARNAEGWTPL 297
+ LLL G RN T L
Sbjct: 236 VVRLLLDSGINAHVRNTYSQTAL 258
Score = 48.5 bits (114), Expect = 1e-05
Identities = 24/60 (40%), Positives = 36/60 (60%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNI 221
T+PLH+AA GH +++RLLL+ + TALHEA G T V +LL +G + ++
Sbjct: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249
Score = 40.0 bits (92), Expect = 0.005
Identities = 35/103 (33%), Positives = 43/103 (41%), Gaps = 10/103 (9%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRA-------RPDSA--PGGRTALHEACAAGHTACVHVLL 213
TPL +A G V++LLL RP A P G + LH A GH + +LL
Sbjct: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
Query: 214 VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRS 256
AG D N + G LH G E LLL G R+
Sbjct: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRN 251
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 103 bits (257), Expect = 4e-22
Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%)
Query: 32 AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90
A +PPP S P S +G GEP R P C L +
Sbjct: 527 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 567
Query: 91 IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149
T +SGP+L GC+S + G A + + ER + RF+ R
Sbjct: 568 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 619
Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206
L +++ +G + + L+L P+ RT LH A G
Sbjct: 620 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 664
Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
HVLL AGA+ N D+ + PL LE A +++ G V + EE+ T LH
Sbjct: 665 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 723
Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
AA++G++E+ LLL G +A+++ GWTP++ A + + +++ +L
Sbjct: 724 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 770
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
L+ GAD D ++ LH A G AA+ E+LL+ + ++Y G TPLH A
Sbjct: 771 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
Score = 66.6 bits (161), Expect = 5e-11
Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215
EE+ +T LH AA G+ E++ LLL +A GG T + A H + +LL
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274
GAD + D + LH G+ AE+LL AR D + +TPLH+AAR + +
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 831
Query: 275 LADLLLRRGACPDARNAEGWT 295
L L RGA P+ RN EG T
Sbjct: 832 CVLLFLSRGANPELRNKEGDT 852
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 103 bits (257), Expect = 4e-22
Identities = 98/354 (27%), Positives = 151/354 (42%), Gaps = 62/354 (17%)
Query: 32 AYTSPPPHSP-FPAHMLMSWSPEECKGQGEPLDDRHPLCARLVEKPSRGSEEHLKSGPGP 90
A +PPP S P S +G GEP R P C L +
Sbjct: 561 AAPAPPPLSQDVPGRADTSQPSARMRGHGEP---RRPPCDPLAD---------------- 601
Query: 91 IVTRTASGPALAFWQAVLAGDVGCVSRILADSSTGL-APDSVFDTSDPERWRDFRFNIRA 149
T +SGP+L GC+S + G A + + ER + RF+ R
Sbjct: 602 --TIDSSGPSLTLPNG------GCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQ 653
Query: 150 LRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHT 206
L +++ +G + + L+L P+ RT LH A G
Sbjct: 654 L---------------YLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSV 698
Query: 207 ACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHV 266
HVLL AGA+ N D+ + PL LE A +++ G V + EE+ T LH
Sbjct: 699 EICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK-EEDGSTCLHH 757
Query: 267 AARLGHVELADLLLRRGACP-DARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLL 325
AA++G++E+ LLL G +A+++ GWTP++ A + + +++ +L
Sbjct: 758 AAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAE-------------HKHIEVIRML 804
Query: 326 LSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
L+ GAD D ++ LH A G AA+ E+LL+ + ++Y G TPLH A
Sbjct: 805 LTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Score = 66.6 bits (161), Expect = 5e-11
Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 5/141 (3%)
Query: 158 EEELTTPLHVAASRGHTEVLRLLLRRRARPDSAP--GGRTALHEACAAGHTACVHVLLVA 215
EE+ +T LH AA G+ E++ LLL +A GG T + A H + +LL
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 216 GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEE-ETPLHVAARLGHVE 274
GAD + D + LH G+ AE+LL AR D + +TPLH+AAR + +
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLN--ARCDLHAVNYHGDTPLHIAARESYHD 865
Query: 275 LADLLLRRGACPDARNAEGWT 295
L L RGA P+ RN EG T
Sbjct: 866 CVLLFLSRGANPELRNKEGDT 886
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 102 bits (254), Expect = 8e-22
Identities = 89/246 (36%), Positives = 114/246 (46%), Gaps = 30/246 (12%)
Query: 163 TPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTA---LHEACAAGHTACVHVLLVA-GAD 218
TP+HVA G ++R+LLRR D + G+ A LH A GH V +L G
Sbjct: 539 TPMHVACQHGQENIVRILLRRGV--DVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 219 PNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADL 278
N DG+ PLHL G A +L+ + V+ S + TPLHVAA GH A L
Sbjct: 597 VNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-TPLHVAAETGHTSTARL 655
Query: 279 LLRRGACPDARNAEGWTPL-LAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQ 337
LL RGA +A ++G+T L LAA + ++ LL+ AD A
Sbjct: 656 LLHRGAGKEAMTSDGYTALHLAARNGHLATV--------------KLLVEEKADVLARGP 701
Query: 338 DKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRA 397
Q LHLA GH+ VVE L+S V + D G + LH A QG A V
Sbjct: 702 LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHA-------QTVET 753
Query: 398 LLNHGA 403
LL HGA
Sbjct: 754 LLRHGA 759
Score = 93.2 bits (230), Expect = 5e-19
Identities = 79/259 (30%), Positives = 111/259 (42%), Gaps = 41/259 (15%)
Query: 172 GHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLH 231
G T L +L+ + + G + LH A AG C LL+ A+PN++++ G PLH
Sbjct: 417 GDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLH 476
Query: 232 LCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNA 291
+ ELLL V+ + +E++ T LH AA+ G LLL + A + +
Sbjct: 477 MAVERRVRGVVELLLARKISVNAK-DEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
Query: 292 EGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGH 351
EG TP+ AC ++I +LL G D +D PLH A +GH
Sbjct: 536 EGRTPMHVACQHGQENIV-------------RILLRRGVDVSLQGKDAWLPLHYAAWQGH 582
Query: 352 AAVVELLL-SCGVSANTMDYGGHTPLHCALQ-----------------GPAAALAQSPEH 393
+V+LL GVS N G TPLH A Q + LAQ+P H
Sbjct: 583 LPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLH 642
Query: 394 V---------VRALLNHGA 403
V R LL+ GA
Sbjct: 643 VAAETGHTSTARLLLHRGA 661
Score = 88.2 bits (217), Expect = 2e-17
Identities = 68/220 (30%), Positives = 98/220 (44%), Gaps = 16/220 (7%)
Query: 162 TTPLHVAASRGHTEVLRLLLRRRARPDSAPGGR-TALHEACAAGHTACVHVLLVAGADPN 220
+TPLH+A R V+ LLL R+ ++ + TALH A G + +LL A N
Sbjct: 472 STPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVN 531
Query: 221 IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL 280
D +G+ P+H+ G +LLR G V + ++ PLH AA GH+ + LL
Sbjct: 532 EVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDAWLPLHYAAWQGHLPIVKLLA 590
Query: 281 RR-GACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDK 339
++ G +A+ +G TPL A + + +CSLL
Sbjct: 591 KQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLL-------------A 637
Query: 340 QRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 379
Q PLH+A GH + LLL G M G+T LH A
Sbjct: 638 QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 677
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,435,216
Number of Sequences: 37866
Number of extensions: 1189857
Number of successful extensions: 8902
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 3327
Number of HSP's gapped (non-prelim): 2066
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.