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Search of human proteins with 21264330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264330 mindbomb homolog 2 [Homo sapiens]
(1013 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264330 mindbomb homolog 2 [Homo sapiens] 2070 0.0
gi|30348954 mindbomb homolog 1 [Homo sapiens] 682 0.0
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 139 1e-32
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 134 4e-31
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 134 4e-31
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 134 4e-31
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 130 8e-30
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 127 4e-29
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 126 1e-28
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 122 1e-27
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 121 4e-27
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 119 1e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 116 1e-25
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 116 1e-25
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 116 1e-25
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 116 1e-25
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 114 5e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 111 3e-24
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 109 1e-23
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 108 3e-23
gi|34304381 inversin isoform a [Homo sapiens] 107 7e-23
gi|34304379 inversin isoform b [Homo sapiens] 107 7e-23
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 103 8e-22
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 102 2e-21
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 102 2e-21
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 102 2e-21
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 101 4e-21
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 101 4e-21
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 101 4e-21
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 101 4e-21
>gi|21264330 mindbomb homolog 2 [Homo sapiens]
Length = 1013
Score = 2070 bits (5363), Expect = 0.0
Identities = 1013/1013 (100%), Positives = 1013/1013 (100%)
Query: 1 MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTTDPSAHRSRAAPPNMD 60
MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTTDPSAHRSRAAPPNMD
Sbjct: 1 MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRAARPTTDPSAHRSRAAPPNMD 60
Query: 61 PDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRT 120
PDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRT
Sbjct: 61 PDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRT 120
Query: 121 NYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHN 180
NYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHN
Sbjct: 121 NYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHN 180
Query: 181 KHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPG 240
KHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPG
Sbjct: 181 KHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPG 240
Query: 241 RVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGK 300
RVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGK
Sbjct: 241 RVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGK 300
Query: 301 PAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDR 360
PAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDR
Sbjct: 301 PAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDR 360
Query: 361 GDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALG 420
GDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALG
Sbjct: 361 GDVRVQFNHETRWTFHPGALTKHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALG 420
Query: 421 RVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDK 480
RVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDK
Sbjct: 421 RVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDK 480
Query: 481 LRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIR 540
LRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIR
Sbjct: 481 LRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIR 540
Query: 541 LLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRG 600
LLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRG
Sbjct: 541 LLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRG 600
Query: 601 FLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFT 660
FLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFT
Sbjct: 601 FLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFT 660
Query: 661 LLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVN 720
LLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVN
Sbjct: 661 LLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVN 720
Query: 721 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGA 780
VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGA
Sbjct: 721 VRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGA 780
Query: 781 GGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRV 840
GGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRV
Sbjct: 781 GGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRV 840
Query: 841 LKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLV 900
LKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLV
Sbjct: 841 LKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLV 900
Query: 901 LFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRY 960
LFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRY
Sbjct: 901 LFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVASAAPAPGPPRQLVEELQSRY 960
Query: 961 RQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1013
RQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
Sbjct: 961 RQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV 1013
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 682 bits (1759), Expect = 0.0
Identities = 394/1022 (38%), Positives = 560/1022 (54%), Gaps = 107/1022 (10%)
Query: 69 VGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQG 128
VG RVVRG DWKWG+QDGGEG VGTV S +P+ VVV WD GT NYR G
Sbjct: 14 VGARVVRGPDWKWGKQDGGEGHVGTV------RSFESPEEVVVV-WDNGTAANYRCS--G 64
Query: 129 AHDLLLYDNAQIGVRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAF 188
A+DL + D+A G++H +CD C++ + G+RWKC C +YDLCT CY +KH L H F
Sbjct: 65 AYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRF 124
Query: 189 DRYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGW 248
R T S V L R+ +I RGIF GA+VVRG DW+W QDGG G+ G+V +I+ W
Sbjct: 125 YRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDW 184
Query: 249 DVETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRV 308
+ S A V W +G N+YRVG +G DLKCV +A GG +Y+DH P LG ++
Sbjct: 185 SASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLG-----EQNG 239
Query: 309 SADSQPFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFN 368
+ + Q GD V LD ++++ +Q GHGGW M E + TGTV I + D+ VQ+
Sbjct: 240 NRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYP 299
Query: 369 HETRWTFHPGALTKHH----------------SFWVGDVVRVIGDLDTVKRLQAGHGEWT 412
RWTF+P LTK + F VGD+V+V DL+ +K LQ GHGEW
Sbjct: 300 SGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWA 359
Query: 413 DDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKS 472
+ M P LG+VG+V +++ D +L+V V G WT++P+ + + + A A N S
Sbjct: 360 EAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAV--------SKVASAGSAISNAS 411
Query: 473 S--LSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVA 530
LS L KL + + LV A G+ A+ DLL+R V+ + G TA+Q A
Sbjct: 412 GERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAA 471
Query: 531 AYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQS 590
+ G V++++LLL+ V+ D +G+ A+H+AA G++ VL +A N +
Sbjct: 472 SQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQ 531
Query: 591 TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNID 650
T LH+AV +G L+VV+ L + GC +L D+ DTPLH AIS I+ VL E D
Sbjct: 532 TPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAIS--KKRDDILAVLLEA-GAD 588
Query: 651 VTATNSQGFTLLHHASLKGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVA 708
VT TN+ GF LHHA+L+G+ A+R +L++ + +VD KK+DG+TALHLAALNNH EVA
Sbjct: 589 VTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVA 648
Query: 709 QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
++L+ +G +++++N Q+ LHLAV++ H +V LLV AG ++ +D++GDT LH AL+
Sbjct: 649 ELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
Query: 769 RHQLLPL--VAD-------GAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGA 819
H L L + D A +P L+ L G AE A++ACFLA GA
Sbjct: 709 HHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQG----AEKKSAASIACFLAANGA 764
Query: 820 DVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGG---GAAPGPRQTLGTPNTVTN 876
D+S N +G+SPLDL + + KAL C + Q G +TL ++
Sbjct: 765 DLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSD 824
Query: 877 LHVGAAPGP----------------------------EAAECLVCSELALLVLFSPCQHR 908
+ GP + EC+VCS+ VLF PC H
Sbjct: 825 MKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHM 884
Query: 909 TVCEECARRMKKCIRCQVVVSK----------KLRPDGSEVASAAPAPGPPRQL------ 952
CE CA MKKC++C+ VV + K D ++ S+ P +
Sbjct: 885 CACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVN 944
Query: 953 --VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQ 1010
V++LQ + + ++E+ CP+C+D ++F CGHG C CG +S CPICR+ I RI
Sbjct: 945 ADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRIL 1004
Query: 1011 IF 1012
++
Sbjct: 1005 LY 1006
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/76 (44%), Positives = 44/76 (57%), Gaps = 1/76 (1%)
Query: 66 GVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAG 125
G+ G RVVRGVDW+W QDGG G G V E+ + S S+P V WD G + YR G
Sbjct: 150 GIFAGARVVRGVDWQWEDQDGGNGRRGKVTEI-QDWSASSPHSAAYVLWDNGAKNLYRVG 208
Query: 126 YQGAHDLLLYDNAQIG 141
++G DL +A+ G
Sbjct: 209 FEGMSDLKCVQDAKGG 224
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 139 bits (351), Expect = 1e-32
Identities = 100/343 (29%), Positives = 168/343 (48%), Gaps = 14/343 (4%)
Query: 506 ALDLLRRRPEQVDTKNQG-RTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAA 564
A+ +L + V+ +++ +T L +AA V+ L+ + V++ D G TALH+AA
Sbjct: 89 AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148
Query: 565 LGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDT 624
E ++LLS G +A + A+H A G +EVV+ L G +V D S T
Sbjct: 149 FSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT 208
Query: 625 PLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQL 684
PLH+A A +G +V+ L ++ +D+ N+ G T LH A G + V +++ +
Sbjct: 209 PLHAA--ASSGMISVVKYLLDL-GVDMNEPNAYGNTPLHVACYNGQDVVVNELI-DCGAI 264
Query: 685 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPL 744
V+ K E GFT LH AA + H + L+ DVN++++ ++PLH+
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
Query: 745 LVDAGCSVNAEDEEGDTALHVALQ-RHQLL--PLVADGAGGDPGPLQLLSRLQASGLPGS 801
++ +G ++ ED+ G+T LH+A + H+LL L+ GA + + L + L G
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
Query: 802 AELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKAL 844
++ L G D+ + GR+ L AA G L+ L
Sbjct: 385 SD------CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Score = 108 bits (269), Expect = 3e-23
Identities = 102/377 (27%), Positives = 162/377 (42%), Gaps = 27/377 (7%)
Query: 524 RTALQVAAYLGQVELIRLLL---QARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 580
RT + AA G E +RLL+ + + VD+ D G T L + L + LL+ G
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 581 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
DA + TALH G E V AL + G L D+ TP+H +SA G G++
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIH--LSAACGHIGVL 735
Query: 641 EVLTEVP---NIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
L + + + ++ G+T LH A GH V +L +++ + + F+ LH
Sbjct: 736 GALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL--EQEVFQKTEGNAFSPLH 793
Query: 698 LAALNNHREVAQILIRE-GRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
A +N++ A++LI G VN + K ++PLH A HV + LL+ VN+ D
Sbjct: 794 CAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD 853
Query: 757 EEGDTALHVALQRHQ--LLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFL 814
G T L +A + Q + ++ A + LQ S+ A L S A +
Sbjct: 854 STGKTPLMMAAENGQTNTVEMLVSSASAEL-TLQDNSKNTALHLACSKGHETSALLILEK 912
Query: 815 ALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTV 874
+ ++ TN ++PL +AA + +Q G GA+ L
Sbjct: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQ--------ELLGKGAS-----VLAVDENG 959
Query: 875 TNLHVGAAPGPEAAECL 891
+ AP + A+CL
Sbjct: 960 YTPALACAPNKDVADCL 976
Score = 101 bits (251), Expect = 4e-21
Identities = 71/245 (28%), Positives = 114/245 (46%), Gaps = 14/245 (5%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
G L +AA G + R LL + +D PDD G T LH AA G E +LL+ G
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431
Query: 583 DAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEV 642
+ + + LH A + + AL G VN D TPLH A ++ T + +
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 643 LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR-----------ARQLVDAKKED 691
L N + + QG+ +H+++ GH L ++ I + L D+
Sbjct: 492 LRNDANPGI--RDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549
Query: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
+ LHLAA + H + ++L+ + D++VRN ++PL LA + HV V +L++ G S
Sbjct: 550 TISPLHLAAYHGHHQALEVLV-QSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
Query: 752 VNAED 756
+ +D
Sbjct: 609 ILVKD 613
Score = 95.9 bits (237), Expect = 2e-19
Identities = 93/358 (25%), Positives = 142/358 (39%), Gaps = 49/358 (13%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE-ATRVLLSAGCR 581
G T L VA Y GQ ++ L+ A V+ +++G T LH+AA +L+ G
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 298
Query: 582 ADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 641
+ + T LH+ G + + + G ++ D + +TPLH I+A G ++
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH--IAARYGHELLIN 356
Query: 642 VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAAL 701
L D G LH A+L G + RK+L+ +D + G T LH AA
Sbjct: 357 TLI-TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFD-IDTPDDFGRTCLHAAAA 414
Query: 702 NNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDT 761
+ E +L+ G D N +++ +SPLH A + + LV +G SVN DE G T
Sbjct: 415 GGNLECLNLLLNTG-ADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT 473
Query: 762 ALHVA------------LQRHQLLPLVADGAG-------------------GDPGPLQLL 790
LH A L R+ P + D G PL +L
Sbjct: 474 PLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVL 533
Query: 791 SRLQASGLPGSAELTVGAAVACFLALEG------------ADVSYTNHRGRSPLDLAA 836
+ + ++ + A G D+ N GR+PLDLAA
Sbjct: 534 METSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591
Score = 85.1 bits (209), Expect = 3e-16
Identities = 69/251 (27%), Positives = 113/251 (45%), Gaps = 7/251 (2%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
G+T L ++ G + + LL A VD D G TALH A+ E LL G +
Sbjct: 653 GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712
Query: 583 DAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAI--SAGTGASGIV 640
+S T +H++ G + V+ AL + ++ A +D ++A+ + G V
Sbjct: 713 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV 772
Query: 641 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKIL-ARARQLVDAKKEDGFTALHLA 699
E+L E T N+ F+ LH A + + A ++ +V+A G T LH A
Sbjct: 773 ELLLEQEVFQKTEGNA--FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830
Query: 700 ALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLV-DAGCSVNAEDEE 758
A +H E Q+L+ VN + ++PL +A + V +LV A + +D
Sbjct: 831 AFTDHVECLQLLLSH-NAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889
Query: 759 GDTALHVALQR 769
+TALH+A +
Sbjct: 890 KNTALHLACSK 900
Score = 82.0 bits (201), Expect = 3e-15
Identities = 80/282 (28%), Positives = 124/282 (43%), Gaps = 14/282 (4%)
Query: 494 LVVEVALGNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLP 552
L++ V G+ LL + VD K++ GRTAL A G E + LLQ A L
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 553 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQS----TALHVAVQRGFLEVVRAL 608
D G T +H +A LL + DA +T TALH A G V L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNID-VTATNSQGFTLLHHASL 667
E+ + ++ +PLH A+ G E+L + V AT+S+G T LH A+
Sbjct: 776 LEQEV-FQKTEGNAFSPLHCAVI--NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAF 832
Query: 668 KGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQ 727
H ++ +L+ Q V++ G T L +AA N ++L+ ++ +++
Sbjct: 833 TDHVECLQLLLSHNAQ-VNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN 891
Query: 728 SPLHLAVQQAHVGLVPLLVDAGCS---VNAEDEEGDTALHVA 766
+ LHLA + H L+++ +NA + T LHVA
Sbjct: 892 TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933
Score = 60.8 bits (146), Expect = 6e-09
Identities = 46/146 (31%), Positives = 72/146 (49%), Gaps = 7/146 (4%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLL-S 577
T ++GRT L AA+ VE ++LLL A V+ D G T L AA Q +L+ S
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Query: 578 AGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCD---VNLPDAHSDTPLHSAISAGT 634
A +++++TALH+A +G + E+ D +N +A TPLH ++A
Sbjct: 879 ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLH--VAARN 936
Query: 635 GASGIVEVLTEVPNIDVTATNSQGFT 660
G + +V+ L V A + G+T
Sbjct: 937 GLTMVVQELLG-KGASVLAVDENGYT 961
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 134 bits (337), Expect = 4e-31
Identities = 118/417 (28%), Positives = 188/417 (45%), Gaps = 49/417 (11%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N + ++LL + + + G T + VAA++G + ++ LLLQ A D+ + G TAL
Sbjct: 388 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 447
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA Q E R LL G DA + T LH+A + G E+V+ L + +
Sbjct: 448 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 507
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
+ TPLH ISA G + VL E AT +GFT LH A+ G +L V K+L +
Sbjct: 508 NGYTPLH--ISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYG-SLDVAKLLLQ 563
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------------------------ 716
R D+ ++G T LH+AA ++++VA +L+ +G
Sbjct: 564 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623
Query: 717 --------CDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
+ N+ ++ +PLHLA Q+ H +V LL+D G +++ + G T+LH+A Q
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Query: 769 RHQLLP---LVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTN 825
++ L GA D + L + G+ ++ FL +GA+V+
Sbjct: 684 EDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM------VNFLLKQGANVNAKT 737
Query: 826 HRGRSPLDLAAE---GRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHV 879
G +PL AA+ ++ L + A G A + LG + V L V
Sbjct: 738 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 794
Score = 113 bits (283), Expect = 8e-25
Identities = 115/394 (29%), Positives = 166/394 (42%), Gaps = 49/394 (12%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T G T L +AA+ G V + LLL A VD G T LH A+ ++LL
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASG 638
G + DA T LH A + G +VV L ERG + + +PLH A + G
Sbjct: 268 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-AQGDHVEC 326
Query: 639 IVEVLT-EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
+ +L + P DVT T LH A+ GH V K+L R +A+ +GFT LH
Sbjct: 327 VKHLLQHKAPVDDVTL---DYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGFTPLH 382
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
+A N +V ++L++ G + +P+H+A H+ +V LL+ G S + +
Sbjct: 383 IACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 441
Query: 758 EGDTALHVALQRHQLL---------PLVADGAGGDPGPLQLLSRL--------------- 793
G+TALH+A + Q+ LV A + PL + SRL
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501
Query: 794 -QASGLPGSAELTVGAA-----VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGC 847
A+ G L + A VA L GA S +G +PL +AA+ L +
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Query: 848 AQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGA 881
QR + G N +T LHV A
Sbjct: 562 LQRRAAADSAG------------KNGLTPLHVAA 583
Score = 109 bits (273), Expect = 1e-23
Identities = 85/277 (30%), Positives = 140/277 (50%), Gaps = 23/277 (8%)
Query: 501 GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 559
GN + ++ L+ + ++T NQ G AL +AA G V L++ LL + VD +GNTA
Sbjct: 21 GNLDKVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 79
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH A+L Q E +VL+ G +A + T L++A Q ++VV+ L E G + +
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 139
Query: 620 AHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQG---FTLLHHASLKGHALAVRK 676
TPL A++ G + V +L E +++G LH A+ K +
Sbjct: 140 EDGFTPL--AVALQQGHNQAVAILLE--------NDTKGKVRLPALHIAARKDDTKSAAL 189
Query: 677 IL-------ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSP 729
+L +++ +V+ E GFT LH+AA + VA +L+ G V+ R +P
Sbjct: 190 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITP 248
Query: 730 LHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVA 766
LH+A ++ + +V LL+D G ++A+ +G T LH A
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA 285
Score = 103 bits (258), Expect = 6e-22
Identities = 105/360 (29%), Positives = 153/360 (42%), Gaps = 36/360 (10%)
Query: 509 LLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q+D K + G T L AA G +++ LLL+ A + G + LH AA G+
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
E + LL D + TALHVA G V + L ++ + N + TPLH
Sbjct: 323 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 382
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDA 687
I+ ++E+L + + A G T +H A+ GH L + +L + D
Sbjct: 383 --IACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGH-LNIVLLLLQNGASPDV 438
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
G TALH+AA EV + L+R G V+ R R+ Q+PLH+A + +V LL+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Query: 748 AGCSVNAEDEEGDTALHVALQRHQL-----------------------LPLVADGAGGDP 784
+A G T LH++ + Q+ L + A D
Sbjct: 498 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 557
Query: 785 GPLQLLSRLQA--SGLPGSAELTVGA-----AVACFLALEGADVSYTNHRGRSPLDLAAE 837
L L R A +G G L V A VA L +GA T G +PL +AA+
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
Score = 97.1 bits (240), Expect = 8e-20
Identities = 107/375 (28%), Positives = 163/375 (43%), Gaps = 36/375 (9%)
Query: 520 KNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAG 579
K+ + AA G ++ + L+ ++ + G ALH AA + LL G
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 580 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 639
D+ +TALH+A G EVV+ L + G ++N + TPL+ A A +
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA--AQENHIDV 124
Query: 640 VEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLA 699
V+ L E TAT GFT L A +GH AV +L D K + ALH+A
Sbjct: 125 VKYLLENGANQSTAT-EDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIA 178
Query: 700 ALNNHREVAQILIR-EGRCDVNVR---NRKLQS---PLHLAVQQAHVGLVPLLVDAGCSV 752
A + + A +L++ + DV + NR +S PLH+A +V + LL++ G +V
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 753 NAEDEEGDTALHVALQR--HQLLPLVADGAGG-DPGPLQLLSRLQASGLPGSAELTVGAA 809
+ G T LHVA +R ++ L+ D G D L+ L + G +
Sbjct: 239 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQ------ 292
Query: 810 VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLG 869
V L GA + G SPL +AA+G ++ ++ Q AP TL
Sbjct: 293 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH---------KAPVDDVTL- 342
Query: 870 TPNTVTNLHVGAAPG 884
+ +T LHV A G
Sbjct: 343 --DYLTALHVAAHCG 355
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 134 bits (337), Expect = 4e-31
Identities = 118/417 (28%), Positives = 188/417 (45%), Gaps = 49/417 (11%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N + ++LL + + + G T + VAA++G + ++ LLLQ A D+ + G TAL
Sbjct: 409 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA Q E R LL G DA + T LH+A + G E+V+ L + +
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
+ TPLH ISA G + VL E AT +GFT LH A+ G +L V K+L +
Sbjct: 529 NGYTPLH--ISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYG-SLDVAKLLLQ 584
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------------------------ 716
R D+ ++G T LH+AA ++++VA +L+ +G
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 717 --------CDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
+ N+ ++ +PLHLA Q+ H +V LL+D G +++ + G T+LH+A Q
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 769 RHQLLP---LVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTN 825
++ L GA D + L + G+ ++ FL +GA+V+
Sbjct: 705 EDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM------VNFLLKQGANVNAKT 758
Query: 826 HRGRSPLDLAAE---GRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHV 879
G +PL AA+ ++ L + A G A + LG + V L V
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 815
Score = 113 bits (283), Expect = 8e-25
Identities = 115/394 (29%), Positives = 166/394 (42%), Gaps = 49/394 (12%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T G T L +AA+ G V + LLL A VD G T LH A+ ++LL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASG 638
G + DA T LH A + G +VV L ERG + + +PLH A + G
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-AQGDHVEC 347
Query: 639 IVEVLT-EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
+ +L + P DVT T LH A+ GH V K+L R +A+ +GFT LH
Sbjct: 348 VKHLLQHKAPVDDVTL---DYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGFTPLH 403
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
+A N +V ++L++ G + +P+H+A H+ +V LL+ G S + +
Sbjct: 404 IACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 758 EGDTALHVALQRHQLL---------PLVADGAGGDPGPLQLLSRL--------------- 793
G+TALH+A + Q+ LV A + PL + SRL
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 794 -QASGLPGSAELTVGAA-----VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGC 847
A+ G L + A VA L GA S +G +PL +AA+ L +
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 848 AQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGA 881
QR + G N +T LHV A
Sbjct: 583 LQRRAAADSAG------------KNGLTPLHVAA 604
Score = 112 bits (280), Expect = 2e-24
Identities = 92/318 (28%), Positives = 155/318 (48%), Gaps = 25/318 (7%)
Query: 460 NLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDT 519
N D A+++ + + + R +KSD + GN + ++ L+ + ++T
Sbjct: 3 NEDAAQKSDSGEKFNGSSQRRKRPKKSDSN--ASFLRAARAGNLDKVVEYLKGGID-INT 59
Query: 520 KNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
NQ G AL +AA G V L++ LL + VD +GNTALH A+L Q E +VL+
Sbjct: 60 CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASG 638
G +A + T L++A Q ++VV+ L E G + + TPL A++ G +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL--AVALQQGHNQ 177
Query: 639 IVEVLTEVPNIDVTATNSQG---FTLLHHASLKGHALAVRKIL-------ARARQLVDAK 688
V +L E +++G LH A+ K + +L +++ +V+
Sbjct: 178 AVAILLE--------NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E GFT LH+AA + VA +L+ G V+ R +PLH+A ++ + +V LL+D
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 749 GCSVNAEDEEGDTALHVA 766
G ++A+ +G T LH A
Sbjct: 289 GGQIDAKTRDGLTPLHCA 306
Score = 110 bits (275), Expect = 7e-24
Identities = 134/479 (27%), Positives = 200/479 (41%), Gaps = 54/479 (11%)
Query: 418 ALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVA 477
+L +VVKV + Q F+P Y ++ ++DV + EN ++ S A
Sbjct: 105 SLAGQAEVVKVLVKEGANINAQSQNG-FTP----LYMAAQENHIDVVKYLLENGANQSTA 159
Query: 478 LDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRT-ALQVAAYLGQV 536
+ D P L V + G+ LL DTK + R AL +AA
Sbjct: 160 TE-------DGFTP--LAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDT 205
Query: 537 ELIRLLLQARAGVDLPD--------DEGNTALHYAALGNQPEATRVLLSAGCRADAINST 588
+ LLLQ D+ + G T LH AA +LL+ G D
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 589 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 648
T LHVA +RG +V+ L +RG ++ TPLH A A +G +VE+L E
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA--ARSGHDQVVELLLE-RG 322
Query: 649 IDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVA 708
+ A G + LH A+ H V+ +L + + VD D TALH+AA H V
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 709 QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
++L+ + R + N R +PLH+A ++ + ++ LLV G S+ A E G T +HVA
Sbjct: 382 KLLL-DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 769 RHQL---LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTN 825
L L L+ +GA D ++ + L + G E+ V C L GA V
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV-----VRCLLR-NGALVDARA 494
Query: 826 HRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
++PL +A+ + +Q Q A T N T LH+ A G
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDA------------ATTNGYTPLHISAREG 541
Score = 103 bits (258), Expect = 6e-22
Identities = 105/360 (29%), Positives = 153/360 (42%), Gaps = 36/360 (10%)
Query: 509 LLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q+D K + G T L AA G +++ LLL+ A + G + LH AA G+
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
E + LL D + TALHVA G V + L ++ + N + TPLH
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDA 687
I+ ++E+L + + A G T +H A+ GH L + +L + D
Sbjct: 404 --IACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGH-LNIVLLLLQNGASPDV 459
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
G TALH+AA EV + L+R G V+ R R+ Q+PLH+A + +V LL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 748 AGCSVNAEDEEGDTALHVALQRHQL-----------------------LPLVADGAGGDP 784
+A G T LH++ + Q+ L + A D
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 785 GPLQLLSRLQA--SGLPGSAELTVGA-----AVACFLALEGADVSYTNHRGRSPLDLAAE 837
L L R A +G G L V A VA L +GA T G +PL +AA+
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/150 (28%), Positives = 67/150 (44%), Gaps = 38/150 (25%)
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
K + + L A N +V + L +G D+N N+ + LHLA ++ HVGLV L+
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 748 AGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVG 807
G SV++ ++G+TALH+A L G AE
Sbjct: 86 RGSSVDSATKKGNTALHIA------------------------------SLAGQAE---- 111
Query: 808 AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
V L EGA+++ + G +PL +AA+
Sbjct: 112 --VVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 685 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPL 744
++ ++G ALHLAA H + Q L+ G V+ +K + LH+A +V +
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSATKKGNTALHIASLAGQAEVVKV 115
Query: 745 LVDAGCSVNAEDEEGDTALHVALQRHQL 772
LV G ++NA+ + G T L++A Q + +
Sbjct: 116 LVKEGANINAQSQNGFTPLYMAAQENHI 143
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 134 bits (337), Expect = 4e-31
Identities = 118/417 (28%), Positives = 188/417 (45%), Gaps = 49/417 (11%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N + ++LL + + + G T + VAA++G + ++ LLLQ A D+ + G TAL
Sbjct: 409 NRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL 468
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA Q E R LL G DA + T LH+A + G E+V+ L + +
Sbjct: 469 HMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 528
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
+ TPLH ISA G + VL E AT +GFT LH A+ G +L V K+L +
Sbjct: 529 NGYTPLH--ISAREGQVDVASVLLEAGAAHSLAT-KKGFTPLHVAAKYG-SLDVAKLLLQ 584
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------------------------ 716
R D+ ++G T LH+AA ++++VA +L+ +G
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 717 --------CDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
+ N+ ++ +PLHLA Q+ H +V LL+D G +++ + G T+LH+A Q
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 769 RHQLLP---LVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTN 825
++ L GA D + L + G+ ++ FL +GA+V+
Sbjct: 705 EDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM------VNFLLKQGANVNAKT 758
Query: 826 HRGRSPLDLAAE---GRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHV 879
G +PL AA+ ++ L + A G A + LG + V L V
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKV 815
Score = 113 bits (283), Expect = 8e-25
Identities = 115/394 (29%), Positives = 166/394 (42%), Gaps = 49/394 (12%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T G T L +AA+ G V + LLL A VD G T LH A+ ++LL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASG 638
G + DA T LH A + G +VV L ERG + + +PLH A + G
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA-AQGDHVEC 347
Query: 639 IVEVLT-EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
+ +L + P DVT T LH A+ GH V K+L R +A+ +GFT LH
Sbjct: 348 VKHLLQHKAPVDDVTL---DYLTALHVAAHCGH-YRVTKLLLDKRANPNARALNGFTPLH 403
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
+A N +V ++L++ G + +P+H+A H+ +V LL+ G S + +
Sbjct: 404 IACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNI 462
Query: 758 EGDTALHVALQRHQLL---------PLVADGAGGDPGPLQLLSRL--------------- 793
G+TALH+A + Q+ LV A + PL + SRL
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 794 -QASGLPGSAELTVGAA-----VACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGC 847
A+ G L + A VA L GA S +G +PL +AA+ L +
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 848 AQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGA 881
QR + G N +T LHV A
Sbjct: 583 LQRRAAADSAG------------KNGLTPLHVAA 604
Score = 112 bits (280), Expect = 2e-24
Identities = 92/318 (28%), Positives = 155/318 (48%), Gaps = 25/318 (7%)
Query: 460 NLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDT 519
N D A+++ + + + R +KSD + GN + ++ L+ + ++T
Sbjct: 3 NEDAAQKSDSGEKFNGSSQRRKRPKKSDSN--ASFLRAARAGNLDKVVEYLKGGID-INT 59
Query: 520 KNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
NQ G AL +AA G V L++ LL + VD +GNTALH A+L Q E +VL+
Sbjct: 60 CNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASG 638
G +A + T L++A Q ++VV+ L E G + + TPL A++ G +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPL--AVALQQGHNQ 177
Query: 639 IVEVLTEVPNIDVTATNSQG---FTLLHHASLKGHALAVRKIL-------ARARQLVDAK 688
V +L E +++G LH A+ K + +L +++ +V+
Sbjct: 178 AVAILLE--------NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E GFT LH+AA + VA +L+ G V+ R +PLH+A ++ + +V LL+D
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAA-VDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 749 GCSVNAEDEEGDTALHVA 766
G ++A+ +G T LH A
Sbjct: 289 GGQIDAKTRDGLTPLHCA 306
Score = 110 bits (275), Expect = 7e-24
Identities = 134/479 (27%), Positives = 200/479 (41%), Gaps = 54/479 (11%)
Query: 418 ALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVA 477
+L +VVKV + Q F+P Y ++ ++DV + EN ++ S A
Sbjct: 105 SLAGQAEVVKVLVKEGANINAQSQNG-FTP----LYMAAQENHIDVVKYLLENGANQSTA 159
Query: 478 LDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRT-ALQVAAYLGQV 536
+ D P L V + G+ LL DTK + R AL +AA
Sbjct: 160 TE-------DGFTP--LAVALQQGHNQAVAILLEN-----DTKGKVRLPALHIAARKDDT 205
Query: 537 ELIRLLLQARAGVDLPD--------DEGNTALHYAALGNQPEATRVLLSAGCRADAINST 588
+ LLLQ D+ + G T LH AA +LL+ G D
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 589 QSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPN 648
T LHVA +RG +V+ L +RG ++ TPLH A A +G +VE+L E
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCA--ARSGHDQVVELLLE-RG 322
Query: 649 IDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVA 708
+ A G + LH A+ H V+ +L + + VD D TALH+AA H V
Sbjct: 323 APLLARTKNGLSPLHMAAQGDHVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVT 381
Query: 709 QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
++L+ + R + N R +PLH+A ++ + ++ LLV G S+ A E G T +HVA
Sbjct: 382 KLLL-DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 769 RHQL---LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTN 825
L L L+ +GA D ++ + L + G E+ V C L GA V
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV-----VRCLLR-NGALVDARA 494
Query: 826 HRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
++PL +A+ + +Q Q A T N T LH+ A G
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDA------------ATTNGYTPLHISAREG 541
Score = 103 bits (258), Expect = 6e-22
Identities = 105/360 (29%), Positives = 153/360 (42%), Gaps = 36/360 (10%)
Query: 509 LLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q+D K + G T L AA G +++ LLL+ A + G + LH AA G+
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
E + LL D + TALHVA G V + L ++ + N + TPLH
Sbjct: 344 HVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLH 403
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDA 687
I+ ++E+L + + A G T +H A+ GH L + +L + D
Sbjct: 404 --IACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGH-LNIVLLLLQNGASPDV 459
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
G TALH+AA EV + L+R G V+ R R+ Q+PLH+A + +V LL+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 748 AGCSVNAEDEEGDTALHVALQRHQL-----------------------LPLVADGAGGDP 784
+A G T LH++ + Q+ L + A D
Sbjct: 519 HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDV 578
Query: 785 GPLQLLSRLQA--SGLPGSAELTVGA-----AVACFLALEGADVSYTNHRGRSPLDLAAE 837
L L R A +G G L V A VA L +GA T G +PL +AA+
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/150 (28%), Positives = 67/150 (44%), Gaps = 38/150 (25%)
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
K + + L A N +V + L +G D+N N+ + LHLA ++ HVGLV L+
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 748 AGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVG 807
G SV++ ++G+TALH+A L G AE
Sbjct: 86 RGSSVDSATKKGNTALHIA------------------------------SLAGQAE---- 111
Query: 808 AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
V L EGA+++ + G +PL +AA+
Sbjct: 112 --VVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Score = 48.9 bits (115), Expect = 2e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 1/88 (1%)
Query: 685 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPL 744
++ ++G ALHLAA H + Q L+ G V+ +K + LH+A +V +
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSATKKGNTALHIASLAGQAEVVKV 115
Query: 745 LVDAGCSVNAEDEEGDTALHVALQRHQL 772
LV G ++NA+ + G T L++A Q + +
Sbjct: 116 LVKEGANINAQSQNGFTPLYMAAQENHI 143
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 130 bits (326), Expect = 8e-30
Identities = 113/347 (32%), Positives = 165/347 (47%), Gaps = 14/347 (4%)
Query: 494 LVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPD 553
L V + G+A+ L+ R E G T L VAAY G V+++ LLL+ A VD D
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
Query: 554 DEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC 613
+ G T L AA LL G D+I+S T L +A +G +EVVR L +RG
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL 838
Query: 614 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALA 673
D N D TPLH A A G I E L E ++ G AS +GH
Sbjct: 839 DENHRDDAGWTPLHMA--AFEGHRLICEALIE-QGARTNEIDNDGRIPFILASQEGHYDC 895
Query: 674 VRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLA 733
V +IL + +D + DG AL +AAL HR++ ++L G DVN ++ + L++
Sbjct: 896 V-QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG-ADVNCKDADGRPTLYIL 953
Query: 734 VQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVAL-QRH--QLLPLVADGAGGDPGPLQLL 790
+ + + ++ G +V A D EG TALHV+ Q H + L+A A + +
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
Query: 791 SRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE 837
S LQ++ G + V L GA V +T ++G + L +AA+
Sbjct: 1014 SALQSAAWQGHVK------VVQLLIEHGAVVDHTCNQGATALCIAAQ 1054
Score = 117 bits (292), Expect = 7e-26
Identities = 94/316 (29%), Positives = 146/316 (46%), Gaps = 9/316 (2%)
Query: 456 EEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPE 515
E+D + +A E + S+ LD + + L+ A + ++LL R
Sbjct: 510 EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA 569
Query: 516 QVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRV 574
++ ++ G T L +AA G +++ L+ A ++ D +G TAL AA G E
Sbjct: 570 DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
Query: 575 LLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGT 634
LL AG + D ++ TAL A G ++V L + G +VN D T L +A A
Sbjct: 630 LLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA--AYM 687
Query: 635 GASGIVEVL----TEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE 690
G IVE L EV + DV + L + KGHA V ++ R + VD +
Sbjct: 688 GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE-VDHCDK 746
Query: 691 DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750
DG T L +AA H +V +L+ EG DV+ + ++PL A H +V L+ G
Sbjct: 747 DGMTPLLVAAYEGHVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA 805
Query: 751 SVNAEDEEGDTALHVA 766
+V++ D EG T L +A
Sbjct: 806 AVDSIDSEGRTVLSIA 821
Score = 107 bits (268), Expect = 4e-23
Identities = 96/309 (31%), Positives = 142/309 (45%), Gaps = 23/309 (7%)
Query: 537 ELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVA 596
E+++LL++A A V+ DD + + A + ++ R LL G + +S T L A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 597 VQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNS 656
G L+VV L RG D+ + DAH TPL ++A G + +V L ++ T+
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPL--TLAARQGHTKVVNCLIGC-GANINHTDQ 609
Query: 657 QGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR 716
G+T L A+ GH V +L A VD D TAL AA H ++ L++ G
Sbjct: 610 DGWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG- 667
Query: 717 CDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLV 776
+VN + + ++ L A H +V L+D G VN ED +G TAL VA L
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA-------ALC 720
Query: 777 ADGAGGDPGPLQLL----SRLQASGLPGSAELTVGA-----AVACFLALEGADVSYTNHR 827
+ G + LL + + G L V A V L GADV +T++
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
Query: 828 GRSPLDLAA 836
GR+PL AA
Sbjct: 781 GRTPLLAAA 789
Score = 88.6 bits (218), Expect = 3e-17
Identities = 90/340 (26%), Positives = 141/340 (41%), Gaps = 50/340 (14%)
Query: 494 LVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPD 553
L+ ++G+A+ LL ++GRT L +A+ G VE++R LL + D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 554 DEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQS----------------------- 590
D G T LH AA L+ G R + I++
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 591 ----------TALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
AL VA G ++V L G DVN DA L+ I A +
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLY--ILALENQLTMA 962
Query: 641 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 700
E E +V A++++G T LH + +GH V+ ++A V+A + +AL AA
Sbjct: 963 EYFLE-NGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHAD-VNAADNEKRSALQSAA 1020
Query: 701 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 760
H +V Q+LI G + N+ + L +A Q+ H+ +V +L++ G N D+ G
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQG-ATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 1079
Query: 761 TALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPG 800
TA+ VA + G ++LL + AS L G
Sbjct: 1080 TAMRVAAK------------NGHSQIIKLLEKYGASSLNG 1107
Score = 53.5 bits (127), Expect = 1e-06
Identities = 41/145 (28%), Positives = 72/145 (49%), Gaps = 2/145 (1%)
Query: 484 QKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLL 543
+ SD E L V G+ L+ + N+ R+ALQ AA+ G V++++LL+
Sbjct: 973 EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Query: 544 QARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLE 603
+ A VD ++G TAL AA + +VLL G + + TA+ VA + G +
Sbjct: 1033 EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ 1092
Query: 604 VVRALCERGCDVNLPDAHSDTPLHS 628
+++ L + G + + S +P+H+
Sbjct: 1093 IIKLLEKYG--ASSLNGCSPSPVHT 1115
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 127 bits (320), Expect = 4e-29
Identities = 109/354 (30%), Positives = 160/354 (45%), Gaps = 23/354 (6%)
Query: 493 RLVVEVALGNAARALDLLRRRPEQVDTK-NQGRTALQVAAYLGQVELIRLLLQARAGVDL 551
+LV + G+ ++ + +L+ P+ VD + G + L +A GQ E + LL A +L
Sbjct: 409 KLVDAIVSGDTSKLMKILQ--PQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNL 466
Query: 552 PDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCER 611
+ G+T LH A +LL+ +A + Q TALH A Q G R L E+
Sbjct: 467 SNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEK 526
Query: 612 GCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHA 671
VN D TP+H ++ G IV +L +DV+ + LH+A+ +GH
Sbjct: 527 NASVNEVDFEGRTPMH--VACQHGQENIVRILLR-RGVDVSLQGKDAWLPLHYAAWQGHL 583
Query: 672 LAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLH 731
V+ + + V+A+ DG T LHLAA H VA+ILI + DVNV + Q+PLH
Sbjct: 584 PIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI-DLCSDVNVCSLLAQTPLH 642
Query: 732 LAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL------VADGAGGDPG 785
+A + H LL+ G A +G TALH+A + L + AD P
Sbjct: 643 VAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL 702
Query: 786 PLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGR 839
L A G E V A V + + +G S L LAA+GR
Sbjct: 703 NQTALHLAAAHGHSEVVEELVSADV----------IDLFDEQGLSALHLAAQGR 746
Score = 89.7 bits (221), Expect = 1e-17
Identities = 73/251 (29%), Positives = 108/251 (43%), Gaps = 36/251 (14%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAAL-GN 567
LL + + +GRT + VA GQ ++R+LL+ V L + LHYAA G+
Sbjct: 523 LLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGH 582
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
P + G +A T LH+A QRG V R L + DVN+ + TPLH
Sbjct: 583 LPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLH 642
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR-------KILAR 680
++A TG + +L A S G+T LH A+ GH V+ +LAR
Sbjct: 643 --VAAETGHTSTARLLLH-RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
Query: 681 ------------------------ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR 716
+ ++D E G +ALHLAA H + + L+R G
Sbjct: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHG- 758
Query: 717 CDVNVRNRKLQ 727
+N+++ K Q
Sbjct: 759 AHINLQSLKFQ 769
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 126 bits (316), Expect = 1e-28
Identities = 100/358 (27%), Positives = 161/358 (44%), Gaps = 13/358 (3%)
Query: 506 ALDLLRRRPEQVDTKNQG-RTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAA 564
A+ +L + V+ +++ +T L VAA V+ +++ + V++ D G TALH+AA
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
Query: 565 LGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDT 624
L E +LL+ G +A + ALH A G L+VV L G +V D T
Sbjct: 124 LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
Query: 625 PLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQL 684
PLH+A A G +V+ L + +++ N G T LH A G V +++
Sbjct: 184 PLHAA--ASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN- 239
Query: 685 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPL 744
V+ +GFT LH AA + H + L+ DVN++++ +SPLH+
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT 299
Query: 745 LVDAGCSVNAEDEEGDTALHVALQ-RHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAE 803
L+ G ++ D++G+T LHVA + H+LL +G D + S A
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH----LAA 355
Query: 804 LTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEG---RVLKALQGCAQRFRERQAGG 858
L + L G ++ + GR+ L AA G +K LQ F ++ G
Sbjct: 356 LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Score = 119 bits (297), Expect = 2e-26
Identities = 106/351 (30%), Positives = 159/351 (45%), Gaps = 32/351 (9%)
Query: 499 ALGNAARALDLLRRRPEQVDT-KNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGN 557
AL ++LL + ++ + R AL AAY+G ++++ LL+ A V D +G
Sbjct: 123 ALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY 182
Query: 558 TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNL 617
T LH AA Q + LL+ G D IN +TALH+A G VV L + G +VN
Sbjct: 183 TPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQ 242
Query: 618 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 677
P+ + TPLH A +A T + +E+L DV + G + LH ++ G + +
Sbjct: 243 PNNNGFTPLHFA-AASTHGALCLELLVN-NGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300
Query: 678 LARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQA 737
+ + +D +DG T LH+AA H E+ +R D PLHLA A
Sbjct: 301 IQNGGE-IDCVDKDGNTPLHVAARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
Query: 738 HVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
H L+ +G ++ D+ G T LH A AGG+ ++ + LQ+SG
Sbjct: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAA------------AAGGN---VECIKLLQSSG 403
Query: 798 LP-------GSAELTVGAAVACFLALE-----GADVSYTNHRGRSPLDLAA 836
G L AA F +E GA+V+ T+ GR+ L AA
Sbjct: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 107 bits (266), Expect = 7e-23
Identities = 97/332 (29%), Positives = 149/332 (44%), Gaps = 47/332 (14%)
Query: 509 LLRRRPEQVDT-KNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
+L + E V+T ++ RT L VAA+LG E+I LL+ + A V+ D+ T LH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
EA +VL+ +A + T LHVA
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVA------------------------------- 89
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDA 687
+A A A I+ +L+ V ++ G T LHHA+L GH V +LA+ +
Sbjct: 90 AANKAVKCAEVIIPLLSSV-----NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAF 144
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
K+D ALH AA H +V +LI G +V +++K +PLH A + +V L++
Sbjct: 145 DKKDR-RALHWAAYMGHLDVVALLINHG-AEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
Query: 748 AGCSVNAEDEEGDTALHVALQRHQ---LLPLVADGAGGDPGPLQLLSRLQASGLPGSAEL 804
G ++ + G+TALH+A Q + L+ GA + + + L +A
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN-----VNQPNNNGFTPLHFAAAS 257
Query: 805 TVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
T GA L GADV+ + G+SPL + A
Sbjct: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTA 289
Score = 94.4 bits (233), Expect = 5e-19
Identities = 79/257 (30%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 524 RTALQVAAYLGQVELIRLLLQAR---AGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 580
RT L + G +RLLL+ VD+ D +G T L A +A +LL
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 581 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
D ++ TALH + G E V+ L E+ + D+ TPLH A + G A+ +
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARG-HATWLS 728
Query: 641 EVL-TEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARA--RQLVDAKKEDGFTALH 697
E+L + D ++QG+T LH A G+ + +L + R+ + + FT LH
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG----NPFTPLH 784
Query: 698 LAALNNHREVAQILIREGRCD---VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNA 754
A +N+H A +L+ G D V+ R+ K ++PL A HV + LL+ VNA
Sbjct: 785 CAIINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNA 842
Query: 755 EDEEGDTALHVALQRHQ 771
D G TAL +A + Q
Sbjct: 843 VDNSGKTALMMAAENGQ 859
Score = 89.4 bits (220), Expect = 2e-17
Identities = 79/262 (30%), Positives = 116/262 (44%), Gaps = 11/262 (4%)
Query: 514 PEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEAT 572
PE VD K+ +G+T L +A G ++ + LLL+ A VD D G TALH + E
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
Query: 573 RVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGC---DVNLPDAHSDTPLHSA 629
++LL +S T LH A RG + L + D D TPLH A
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA 754
Query: 630 ISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKIL-ARARQLVDAK 688
G +EVL E N FT LH A + H +L A +V +
Sbjct: 755 --CYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSCR 810
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD- 747
+ G T L AA +H E Q+L+R VN + ++ L +A + G V +LV+
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHS-APVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 748 AGCSVNAEDEEGDTALHVALQR 769
A + +D++ +T LH+A +
Sbjct: 870 AQADLTVKDKDLNTPLHLACSK 891
Score = 81.6 bits (200), Expect = 3e-15
Identities = 124/494 (25%), Positives = 194/494 (39%), Gaps = 57/494 (11%)
Query: 321 VKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGAL 380
VK LL+ V + +G +A + GQ V+ + D G Q N+ H A
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAA 256
Query: 381 TKHHSFWVGDVVRVIGDLDTVKR-------LQAGHGEWTDDMAPALGRVGKVVKVFGDGN 433
+ H + + +V D++ + + A HG +T + G++ V DGN
Sbjct: 257 STHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQT-LIQNGGEIDCVDKDGN 315
Query: 434 LRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSD------ 487
+ VA + + + A + + ++L+ D R S
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375
Query: 488 PEHPGRLVVEVAL-GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQA 545
P+ GR + A G + LL+ K++ GRT L AA I L+
Sbjct: 376 PDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT 435
Query: 546 RAGVDLPDDEGNTALHYAA----------LGN---------------QPEAT---RVLLS 577
A V+ DD G TALHYAA LGN + EAT LL
Sbjct: 436 GANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ 495
Query: 578 AGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSD-----TPLHSAISA 632
+ ++H A G + + L ER N SD +PLH ++A
Sbjct: 496 NDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER---TNSGFEESDSGATKSPLH--LAA 550
Query: 633 GTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDG 692
G +EVL + +D+ + +G T L A+ KGH V ++ +
Sbjct: 551 YNGHHQALEVLLQ-SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Query: 693 FTALHLAALNNHREVAQIL--IREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750
T LH + +N H ++L I + V+V++ K Q+PL LAV H+ V LL++
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 751 SVNAEDEEGDTALH 764
+V+ D G TALH
Sbjct: 670 NVDTVDILGCTALH 683
Score = 81.3 bits (199), Expect = 4e-15
Identities = 68/269 (25%), Positives = 113/269 (42%), Gaps = 30/269 (11%)
Query: 527 LQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAIN 586
L +AA + R LL + +D PD G T LH AA G E ++L S+G +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 587 STQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV------ 640
T LH A + L G +VN D T LH A ++ + +
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHD 470
Query: 641 -----EVLTEVPNIDVT--------------ATNSQGFTLLHHASLKGHALAVRKILARA 681
E E+ + T + +G+ +H+A+ GH + +L R
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 682 RQLVDAKKEDGFT--ALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHV 739
+ + + G T LHLAA N H + ++L+ + D+++R+ K ++ L LA + H
Sbjct: 531 NSGFE-ESDSGATKSPLHLAAYNGHHQALEVLL-QSLVDLDIRDEKGRTALDLAAFKGHT 588
Query: 740 GLVPLLVDAGCSVNAEDE-EGDTALHVAL 767
V L++ G S+ +D T LH ++
Sbjct: 589 ECVEALINPGASIFVKDNVTKRTPLHASV 617
Score = 76.3 bits (186), Expect = 1e-13
Identities = 92/376 (24%), Positives = 145/376 (38%), Gaps = 68/376 (18%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE-ATRVLLSAGCR 581
G TAL +A Y GQ ++ L+ A V+ P++ G T LH+AA +L++ G
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
Query: 582 ADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 641
+ + + LH+ G + L + G +++ D +TPLH ++A G ++
Sbjct: 274 VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLH--VAARYGHELLIN 331
Query: 642 VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAAL 701
L D LH A+L H+ RK+L+ + +D + G T LH AA
Sbjct: 332 TL-RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE-IDTPDKFGRTCLHAAAA 389
Query: 702 NNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSV--------- 752
+ E ++L G D + +++ ++PLH A H + LV G +V
Sbjct: 390 GGNVECIKLLQSSG-ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448
Query: 753 ------------------NAED-------------EEGDTALHVALQRHQLLPLVADGAG 781
NA D +E L LQ + P + D G
Sbjct: 449 ALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQ-NDANPSIRDKEG 507
Query: 782 ----------GDPGPLQLLSRLQASGLPGS------AELTVGAAVACFLALEG-----AD 820
G L+LL SG S + L + A ALE D
Sbjct: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVD 567
Query: 821 VSYTNHRGRSPLDLAA 836
+ + +GR+ LDLAA
Sbjct: 568 LDIRDEKGRTALDLAA 583
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 122 bits (307), Expect = 1e-27
Identities = 113/391 (28%), Positives = 170/391 (43%), Gaps = 36/391 (9%)
Query: 505 RALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYA 563
+A LL + D +++ G T L +AA+ G + + LLL A VD T LH A
Sbjct: 216 KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVA 275
Query: 564 ALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSD 623
+ ++LL G + DA T LH + G +VV L +R + +
Sbjct: 276 SKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335
Query: 624 TPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ 683
+PLH A V++L + N+ V + T LH A+ GH V K+L +
Sbjct: 336 SPLHMATQG--DHLNCVQLLLQ-HNVPVDDVTNDYLTALHVAAHCGH-YKVAKVLLDKKA 391
Query: 684 LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVP 743
+AK +GFT LH+A N +V ++L++ G V L +P+H+A HV +V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVS 450
Query: 744 LLVDAGCSVNAEDEEGDTALHVALQRHQ---LLPLVADG------AGGDPGPLQLLSRLQ 794
L+ G S N + G+TALH+A + Q + LV DG A D PL + +RL
Sbjct: 451 QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
Query: 795 AS---------GLPGSAELTVGAA------------VACFLALEGADVSYTNHRGRSPLD 833
+ G +A T G VA FL GA +S T +G +PL
Sbjct: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570
Query: 834 LAAEGRVLKALQGCAQRFRERQAGGGAAPGP 864
+AA+ L+ Q+ A G + P
Sbjct: 571 VAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
Score = 120 bits (301), Expect = 6e-27
Identities = 95/327 (29%), Positives = 152/327 (46%), Gaps = 19/327 (5%)
Query: 460 NLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDT 519
N D+ A E + R +K + + G+ +ALD ++ +
Sbjct: 11 NRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINIC 70
Query: 520 KNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAG 579
G AL +A+ G VE++ LLQ A VD +GNTALH A+L Q E +VL++ G
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 580 CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGI 639
+A + T L++A Q LEVV+ L + G +L TPL A++ G +
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL--AVALQQGHDQV 188
Query: 640 VEVLTEVPNIDVTATNSQG---FTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
V +L E +++G LH A+ K A +L D + + GFT L
Sbjct: 189 VSLLLE--------NDTKGKVRLPALHIAARKDDTKAAALLLQNDNN-ADVESKSGFTPL 239
Query: 697 HLAALNNHREVAQILI-REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAE 755
H+AA + VA +L+ R D RN +PLH+A ++ + +V LL+D G ++A+
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARND--ITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 756 DEEGDTALHVALQ--RHQLLPLVADGA 780
+G T LH + Q++ ++ D A
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLDRA 324
Score = 120 bits (300), Expect = 8e-27
Identities = 111/422 (26%), Positives = 176/422 (41%), Gaps = 59/422 (13%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N + ++LL + + + G T + VAA++G V ++ L+ A + + G TAL
Sbjct: 411 NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL 470
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA Q E R L+ G + +A T LH++ + G ++V+ L ++G N
Sbjct: 471 HMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT 530
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH +SA G + L + ++ T +GFT LH A+ G L V +L +
Sbjct: 531 SGYTPLH--LSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYG-KLEVANLLLQ 586
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------------------------ 716
DA + G T LH+AA ++++VA +L+ +G
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
Query: 717 --------CDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
D N R+ + +HLA Q+ HV +V LL+ +VN ++ G T LH+A Q
Sbjct: 647 ATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Query: 769 RHQL---LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGA-----AVACFLALEGAD 820
++ LV GA + A G L VG + FL A
Sbjct: 707 EDRVNVAEVLVNQGA-----------HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
Query: 821 VSYTNHRGRSPLDLAAE---GRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNL 877
V+ G +PL AA+ ++ L E G A G + LG + V L
Sbjct: 756 VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Query: 878 HV 879
+
Sbjct: 816 KI 817
Score = 111 bits (277), Expect = 4e-24
Identities = 101/365 (27%), Positives = 158/365 (43%), Gaps = 47/365 (12%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL+ D N TAL VAA+ G ++ ++LL +A + G T LH A N+
Sbjct: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412
Query: 569 PEATRVLLSAGCRADAI---------------------------------NSTQSTALHV 595
+ +LL G A+ N TALH+
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472
Query: 596 AVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATN 655
A + G EVVR L + G V TPLH ISA G + IV+ L + A
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH--ISARLGKADIVQQLLQ-QGASPNAAT 529
Query: 656 SQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG 715
+ G+T LH ++ +GH +L L K+ GFT LH+AA EVA +L+++
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKS 588
Query: 716 RCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL--- 772
+ + +PLH+A + + LL+D G S +A + G T LH+A +++Q+
Sbjct: 589 -ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
Query: 773 LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPL 832
L+ GA + Q ++ + + G ++ L A+V+ +N G +PL
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDM------VSLLLGRNANVNLSNKSGLTPL 701
Query: 833 DLAAE 837
LAA+
Sbjct: 702 HLAAQ 706
Score = 107 bits (266), Expect = 7e-23
Identities = 83/290 (28%), Positives = 129/290 (44%), Gaps = 7/290 (2%)
Query: 480 KLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELI 539
++ A+ D + P L + LG A LL++ G T L ++A G ++
Sbjct: 491 QVEAKAKDDQTP--LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 540 RLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQR 599
LL A + + +G T LH AA + E +LL DA + T LHVA
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 600 GFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGF 659
+V L ++G + + TPLH I+A I L E D A QG
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLH--IAAKKNQMDIATTLLEY-GADANAVTRQGI 665
Query: 660 TLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDV 719
+H A+ +GH V +L R V+ + G T LHLAA + VA++L+ +G V
Sbjct: 666 ASVHLAAQEGHVDMVSLLLGRNAN-VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG-AHV 723
Query: 720 NVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR 769
+ + + +PLH+ ++ +V L+ VNA+ + G T LH A Q+
Sbjct: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ 773
Score = 105 bits (262), Expect = 2e-22
Identities = 102/370 (27%), Positives = 161/370 (43%), Gaps = 46/370 (12%)
Query: 504 ARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHY 562
A + LL R ++D K + G T L A G +++ +LL A + G + LH
Sbjct: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 563 AALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHS 622
A G+ ++LL D + + TALHVA G +V + L ++ + N +
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 623 DTPLHSAISAGT----------GAS------------------GIVEVLTEVPN--IDVT 652
TPLH A GAS G V +++++ +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
TN +G T LH A+ G A VR ++ Q V+AK +D T LH++A ++ Q L+
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQ-VEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 772
++G N +PLHL+ ++ H + L+D G S++ ++G T LHVA + +L
Sbjct: 520 QQG-ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
Query: 773 LPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGA-----AVACFLALEGADVSYTNHR 827
VA+ LQ + A+G G L V A VA L +GA
Sbjct: 579 --EVANLL------LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN 630
Query: 828 GRSPLDLAAE 837
G +PL +AA+
Sbjct: 631 GYTPLHIAAK 640
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 121 bits (303), Expect = 4e-27
Identities = 132/498 (26%), Positives = 199/498 (39%), Gaps = 106/498 (21%)
Query: 454 RPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRR 513
+ +E++N R+R+ K A LRA +S GN +ALD LR
Sbjct: 23 KEKEESNRKRRNRSRDRKKKADAATSFLRAARS--------------GNLDKALDHLRNG 68
Query: 514 PEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEAT 572
+ ++T NQ G L +A+ G V+++ LL ++ +GNTALH AAL Q E
Sbjct: 69 VD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127
Query: 573 RVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISA 632
R L++ G +A + T L++A Q LEVV+ L E G + N+ TPL A+
Sbjct: 128 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187
Query: 633 G----------TGASGIVE------------------VLTEVPNIDVTA----------- 653
G G G V +L PN DV +
Sbjct: 188 GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA 247
Query: 654 --------------------TNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGF 693
T G T LH AS +G+ + VR +L R Q ++ K +D
Sbjct: 248 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ-IETKTKDEL 306
Query: 694 TALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVN 753
T LH AA N H +++IL+ G + + + SP+H+A Q H+ V LL+ ++
Sbjct: 307 TPLHCAARNGHVRISEILLDHG-APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Query: 754 AEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVG---- 807
+ T LHVA H++ ++ D G P + L G L +
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKP---------NSRALNGFTPLHIACKKN 415
Query: 808 -AAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQ 866
V L GA + G +PL +A+ L ++ QR GA+P
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR--------GASP---- 463
Query: 867 TLGTPNTVTNLHVGAAPG 884
+ T LH+ A G
Sbjct: 464 NVSNVKVETPLHMAARAG 481
Score = 116 bits (290), Expect = 1e-25
Identities = 84/266 (31%), Positives = 129/266 (48%), Gaps = 5/266 (1%)
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
G+ L LL + Q +G T L VAA G+V + LLL+ A + G T L
Sbjct: 547 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 606
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H A N + ++LL G + T LH+A ++ +EV R+L + G N
Sbjct: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 666
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G A + +L++ N ++ N G T LH + +GH + V +L +
Sbjct: 667 QGVTPLHLAAQEGH-AEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGH-VPVADVLIK 722
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+VDA G+T LH+A+ + ++ + L++ + DVN + + SPLH A QQ H
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTD 781
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVA 766
+V LL+ G S N +G T L +A
Sbjct: 782 IVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 115 bits (289), Expect = 2e-25
Identities = 111/360 (30%), Positives = 167/360 (46%), Gaps = 23/360 (6%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAG 548
+H L V G+ A LL + + G T L +A V ++ LLL+ A
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
+D + G T LH A+ + LL G + N T LH+A + G EV + L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE---VPNIDVTATNSQGFTLLHHA 665
+ VN TPLH A A G + +V++L E PN+ TA G T LH A
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCA--ARIGHTNMVKLLLENNANPNLATTA----GHTPLHIA 543
Query: 666 SLKGHALAVRKILAR-ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNR 724
+ +GH V +L + A Q KK GFT LH+AA VA++L+ E N +
Sbjct: 544 AREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLL-ERDAHPNAAGK 600
Query: 725 KLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAG 781
+PLH+AV ++ +V LL+ G S ++ G T LH+A +++Q+ L+ G
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 660
Query: 782 GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA-EGRV 840
+ +Q ++ L + G AE+ VA L+ + A+ + N G +PL L A EG V
Sbjct: 661 ANAESVQGVTPLHLAAQEGHAEM-----VALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHV 714
Score = 112 bits (280), Expect = 2e-24
Identities = 84/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 509 LLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q++TK + T L AA G V + +LL A + G + +H AA G+
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
+ R+LL D I T LHVA G V + L ++G N + TPLH
Sbjct: 350 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR--ARQLV 685
I+ ++E+L + + A G T LH AS GH V+ +L R + +
Sbjct: 410 --IACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 686 DAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
+ K E T LH+AA H EVA+ L+ + + VN + + Q+PLH A + H +V LL
Sbjct: 467 NVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
Query: 746 VDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 777
++ + N G T LH+A + + ++A
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLA 554
Score = 111 bits (278), Expect = 3e-24
Identities = 95/339 (28%), Positives = 152/339 (44%), Gaps = 15/339 (4%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N R ++LL + +D + G T L VA+++G + +++ LLQ A ++ + + T L
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA E + LL + +A T LH A + G +V+ L E + NL
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G + + + E +T +GFT LH A+ G +L R
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLER 591
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+A ++G T LH+A +N+ ++ ++L+ G + +PLH+A +Q V
Sbjct: 592 DAH-PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG-YTPLHIAAKQNQVE 649
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQR---HQLLPLVADGAGGDPGPLQLLSRLQASG 797
+ L+ G S NAE +G T LH+A Q + L++ A G+ G L+ L
Sbjct: 650 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 709
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L G V T G +PL +A+
Sbjct: 710 QEGH------VPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 108 bits (271), Expect = 2e-23
Identities = 108/383 (28%), Positives = 163/383 (42%), Gaps = 44/383 (11%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL R T G T L +A+ G V ++RLLL A ++ + T LH AA
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
+ +LL G A + +H+A Q L+ VR L + +++ TPLH
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH- 376
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
++A G + +VL + + GFT LH A K H + V ++L + +DA
Sbjct: 377 -VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAV 433
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E G T LH+A+ H + + L++ G NV N K+++PLH+A + H + L+
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRG-ASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 749 GCSVNAEDEEGDTALHVA-----------LQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
VNA+ ++ T LH A L + P +A AG P L +
Sbjct: 493 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP--------LHIAA 544
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCAQRFRERQA 856
G E V L E + T +G +PL +AA+ G+V A+ ER A
Sbjct: 545 REGHVE-----TVLALLEKEASQACMTK-KGFTPLHVAAKYGKV-----RVAELLLERDA 593
Query: 857 GGGAAPGPRQTLGTPNTVTNLHV 879
AA N +T LHV
Sbjct: 594 HPNAA--------GKNGLTPLHV 608
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/281 (30%), Positives = 130/281 (46%), Gaps = 7/281 (2%)
Query: 467 ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGR 524
ARE +AL + A ++ G + VA G A LL R G
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 603
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L VA + +++++LLL P G T LH AA NQ E R LL G A+A
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
+ T LH+A Q G E+V L + + NL + TPLH + A G + +VL
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH--LVAQEGHVPVADVLI 721
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ + V AT G+T LH AS G+ V K L + + V+AK + G++ LH AA H
Sbjct: 722 K-HGVMVDATTRMGYTPLHVASHYGNIKLV-KFLLQHQADVNAKTKLGYSPLHQAAQQGH 779
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
++ +L++ G N + +PL +A + ++ + +L
Sbjct: 780 TDIVTLLLKNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 119 bits (299), Expect = 1e-26
Identities = 82/274 (29%), Positives = 140/274 (51%), Gaps = 7/274 (2%)
Query: 494 LVVEVALGNAARALDLLRRRPEQVDTKNQGRT-ALQVAAYLGQVELIRLLLQARAGVDLP 552
L++ GN + L LL +R ++D +++G + A+ AA G V+ ++ L + + +D+
Sbjct: 383 LLIAAGCGNI-QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441
Query: 553 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERG 612
D G ALH AA + ++L S G + + + T LH A G+ V +ALCE G
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 613 CDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHAL 672
C+VN+ + +TPL +A + G IVE L E D+ A + G LH A +
Sbjct: 502 CNVNIKNREGETPLLTA--SARGYHDIVECLAE-HGADLNACDKDGHIALHLAVRRCQME 558
Query: 673 AVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHL 732
++ +L++ VD + G T LH+A + + + + + E C++++ N+ ++PLHL
Sbjct: 559 VIKTLLSQG-CFVDYQDRHGNTPLHVACKDGNMPIV-VALCEANCNLDISNKYGRTPLHL 616
Query: 733 AVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVA 766
A + +V L G SV A +G TA +A
Sbjct: 617 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 115 bits (289), Expect = 2e-25
Identities = 76/244 (31%), Positives = 130/244 (53%), Gaps = 5/244 (2%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
G L +AA G +++++LL++ + +D+ D G+ A+++AA + + L C
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 583 DAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEV 642
D + + ALHVA + G +V + LC G + N+ D +TPLH A A G + +
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA--AWHGYYSVAKA 496
Query: 643 LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALN 702
L E +V N +G T L AS +G+ V + LA ++A +DG ALHLA
Sbjct: 497 LCEA-GCNVNIKNREGETPLLTASARGYHDIV-ECLAEHGADLNACDKDGHIALHLAVRR 554
Query: 703 NHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTA 762
EV + L+ +G C V+ ++R +PLH+A + ++ +V L +A C+++ ++ G T
Sbjct: 555 CQMEVIKTLLSQG-CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTP 613
Query: 763 LHVA 766
LH+A
Sbjct: 614 LHLA 617
Score = 79.0 bits (193), Expect = 2e-14
Identities = 74/303 (24%), Positives = 133/303 (43%), Gaps = 53/303 (17%)
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
V+ P+ G L AA + ++L+ G R D + S A++ A + G ++ ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV---PNIDVTATNSQGFTLLHHA 665
E C +++ D + LH ++A G + + ++L PNI
Sbjct: 432 SENKCPLDVKDKSGEMALH--VAARYGHADVAQLLCSFGSNPNIQ--------------- 474
Query: 666 SLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRK 725
D ++E T LH AA + + VA+ L G C+VN++NR+
Sbjct: 475 --------------------DKEEE---TPLHCAAWHGYYSVAKALCEAG-CNVNIKNRE 510
Query: 726 LQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQ---LLPLVADGAGG 782
++PL A + + +V L + G +NA D++G ALH+A++R Q + L++ G
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570
Query: 783 DPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLK 842
D + L + G+ + V A ++ +N GR+PL LAA +L
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEA------NCNLDISNKYGRTPLHLAANNGILD 624
Query: 843 ALQ 845
++
Sbjct: 625 VVR 627
Score = 30.8 bits (68), Expect = 6.7
Identities = 49/195 (25%), Positives = 78/195 (40%), Gaps = 31/195 (15%)
Query: 678 LARARQLVDAKKEDGFTA---LHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAV 734
+AR+ +D +ED F +H +N + +L DVN N+ PL +A
Sbjct: 330 VARSDDTLD--EEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAA 387
Query: 735 QQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSR-- 792
++ ++ LL+ G ++ +D+ G A++ A RH G L+ LS
Sbjct: 388 GCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA-ARH-----------GHVDTLKFLSENK 435
Query: 793 --LQASGLPGSAELTVGAA-----VACFLALEGADVSYTNHRGRSPLDLAA---EGRVLK 842
L G L V A VA L G++ + + +PL AA V K
Sbjct: 436 CPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK 495
Query: 843 AL--QGCAQRFRERQ 855
AL GC + R+
Sbjct: 496 ALCEAGCNVNIKNRE 510
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 116 bits (290), Expect = 1e-25
Identities = 84/266 (31%), Positives = 129/266 (48%), Gaps = 5/266 (1%)
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
G+ L LL + Q +G T L VAA G+V + LLL+ A + G T L
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H A N + ++LL G + T LH+A ++ +EV R+L + G N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G A + +L++ N ++ N G T LH + +GH + V +L +
Sbjct: 634 QGVTPLHLAAQEGH-AEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGH-VPVADVLIK 689
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+VDA G+T LH+A+ + ++ + L++ + DVN + + SPLH A QQ H
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVA 766
+V LL+ G S N +G T L +A
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 115 bits (289), Expect = 2e-25
Identities = 111/360 (30%), Positives = 167/360 (46%), Gaps = 23/360 (6%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAG 548
+H L V G+ A LL + + G T L +A V ++ LLL+ A
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
+D + G T LH A+ + LL G + N T LH+A + G EV + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE---VPNIDVTATNSQGFTLLHHA 665
+ VN TPLH A A G + +V++L E PN+ TA G T LH A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCA--ARIGHTNMVKLLLENNANPNLATTA----GHTPLHIA 510
Query: 666 SLKGHALAVRKILAR-ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNR 724
+ +GH V +L + A Q KK GFT LH+AA VA++L+ E N +
Sbjct: 511 AREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLL-ERDAHPNAAGK 567
Query: 725 KLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAG 781
+PLH+AV ++ +V LL+ G S ++ G T LH+A +++Q+ L+ G
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 782 GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA-EGRV 840
+ +Q ++ L + G AE+ VA L+ + A+ + N G +PL L A EG V
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEM-----VALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHV 681
Score = 114 bits (284), Expect = 6e-25
Identities = 122/451 (27%), Positives = 182/451 (40%), Gaps = 92/451 (20%)
Query: 501 GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 559
GN +ALD LR + ++T NQ G L +A+ G V+++ LL ++ +GNTA
Sbjct: 23 GNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH AAL Q E R L++ G +A + T L++A Q LEVV+ L E G + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 620 AHSDTPLHSAISAG----------TGASGIVE------------------VLTEVPNIDV 651
TPL A+ G G G V +L PN DV
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 652 TA-------------------------------TNSQGFTLLHHASLKGHALAVRKILAR 680
+ T G T LH AS +G+ + VR +L R
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
Q ++ K +D T LH AA N H +++IL+ G + + + SP+H+A Q H+
Sbjct: 262 GAQ-IETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTKNGLSPIHMAAQGDHLD 319
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLLSRLQASGL 798
V LL+ ++ + T LHVA H++ ++ D G P + L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKP---------NSRAL 369
Query: 799 PGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRE 853
G L + V L GA + G +PL +A+ L ++ QR
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR--- 426
Query: 854 RQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
GA+P + T LH+ A G
Sbjct: 427 -----GASP----NVSNVKVETPLHMAARAG 448
Score = 112 bits (280), Expect = 2e-24
Identities = 84/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 509 LLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q++TK + T L AA G V + +LL A + G + +H AA G+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
+ R+LL D I T LHVA G V + L ++G N + TPLH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR--ARQLV 685
I+ ++E+L + + A G T LH AS GH V+ +L R + +
Sbjct: 377 --IACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 686 DAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
+ K E T LH+AA H EVA+ L+ + + VN + + Q+PLH A + H +V LL
Sbjct: 434 NVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 746 VDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 777
++ + N G T LH+A + + ++A
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Score = 111 bits (278), Expect = 3e-24
Identities = 95/339 (28%), Positives = 152/339 (44%), Gaps = 15/339 (4%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N R ++LL + +D + G T L VA+++G + +++ LLQ A ++ + + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA E + LL + +A T LH A + G +V+ L E + NL
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G + + + E +T +GFT LH A+ G +L R
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLER 558
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+A ++G T LH+A +N+ ++ ++L+ G + +PLH+A +Q V
Sbjct: 559 DAH-PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG-YTPLHIAAKQNQVE 616
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQR---HQLLPLVADGAGGDPGPLQLLSRLQASG 797
+ L+ G S NAE +G T LH+A Q + L++ A G+ G L+ L
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L G V T G +PL +A+
Sbjct: 677 QEGH------VPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 108 bits (271), Expect = 2e-23
Identities = 108/383 (28%), Positives = 163/383 (42%), Gaps = 44/383 (11%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL R T G T L +A+ G V ++RLLL A ++ + T LH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
+ +LL G A + +H+A Q L+ VR L + +++ TPLH
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH- 343
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
++A G + +VL + + GFT LH A K H + V ++L + +DA
Sbjct: 344 -VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAV 400
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E G T LH+A+ H + + L++ G NV N K+++PLH+A + H + L+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRG-ASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 749 GCSVNAEDEEGDTALHVA-----------LQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
VNA+ ++ T LH A L + P +A AG P L +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP--------LHIAA 511
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCAQRFRERQA 856
G E V L E + T +G +PL +AA+ G+V A+ ER A
Sbjct: 512 REGHVE-----TVLALLEKEASQACMTK-KGFTPLHVAAKYGKV-----RVAELLLERDA 560
Query: 857 GGGAAPGPRQTLGTPNTVTNLHV 879
AA N +T LHV
Sbjct: 561 HPNAA--------GKNGLTPLHV 575
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/281 (30%), Positives = 130/281 (46%), Gaps = 7/281 (2%)
Query: 467 ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGR 524
ARE +AL + A ++ G + VA G A LL R G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L VA + +++++LLL P G T LH AA NQ E R LL G A+A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
+ T LH+A Q G E+V L + + NL + TPLH + A G + +VL
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH--LVAQEGHVPVADVLI 688
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ + V AT G+T LH AS G+ V K L + + V+AK + G++ LH AA H
Sbjct: 689 K-HGVMVDATTRMGYTPLHVASHYGNIKLV-KFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
++ +L++ G N + +PL +A + ++ + +L
Sbjct: 747 TDIVTLLLKNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 116 bits (290), Expect = 1e-25
Identities = 84/266 (31%), Positives = 129/266 (48%), Gaps = 5/266 (1%)
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
G+ L LL + Q +G T L VAA G+V + LLL+ A + G T L
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H A N + ++LL G + T LH+A ++ +EV R+L + G N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G A + +L++ N ++ N G T LH + +GH + V +L +
Sbjct: 634 QGVTPLHLAAQEGH-AEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGH-VPVADVLIK 689
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+VDA G+T LH+A+ + ++ + L++ + DVN + + SPLH A QQ H
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVA 766
+V LL+ G S N +G T L +A
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 115 bits (289), Expect = 2e-25
Identities = 111/360 (30%), Positives = 167/360 (46%), Gaps = 23/360 (6%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAG 548
+H L V G+ A LL + + G T L +A V ++ LLL+ A
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
+D + G T LH A+ + LL G + N T LH+A + G EV + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE---VPNIDVTATNSQGFTLLHHA 665
+ VN TPLH A A G + +V++L E PN+ TA G T LH A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCA--ARIGHTNMVKLLLENNANPNLATTA----GHTPLHIA 510
Query: 666 SLKGHALAVRKILAR-ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNR 724
+ +GH V +L + A Q KK GFT LH+AA VA++L+ E N +
Sbjct: 511 AREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLL-ERDAHPNAAGK 567
Query: 725 KLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAG 781
+PLH+AV ++ +V LL+ G S ++ G T LH+A +++Q+ L+ G
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 782 GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA-EGRV 840
+ +Q ++ L + G AE+ VA L+ + A+ + N G +PL L A EG V
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEM-----VALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHV 681
Score = 114 bits (284), Expect = 6e-25
Identities = 122/451 (27%), Positives = 182/451 (40%), Gaps = 92/451 (20%)
Query: 501 GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 559
GN +ALD LR + ++T NQ G L +A+ G V+++ LL ++ +GNTA
Sbjct: 23 GNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH AAL Q E R L++ G +A + T L++A Q LEVV+ L E G + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 620 AHSDTPLHSAISAG----------TGASGIVE------------------VLTEVPNIDV 651
TPL A+ G G G V +L PN DV
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 652 TA-------------------------------TNSQGFTLLHHASLKGHALAVRKILAR 680
+ T G T LH AS +G+ + VR +L R
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
Q ++ K +D T LH AA N H +++IL+ G + + + SP+H+A Q H+
Sbjct: 262 GAQ-IETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTKNGLSPIHMAAQGDHLD 319
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLLSRLQASGL 798
V LL+ ++ + T LHVA H++ ++ D G P + L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKP---------NSRAL 369
Query: 799 PGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRE 853
G L + V L GA + G +PL +A+ L ++ QR
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR--- 426
Query: 854 RQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
GA+P + T LH+ A G
Sbjct: 427 -----GASP----NVSNVKVETPLHMAARAG 448
Score = 112 bits (280), Expect = 2e-24
Identities = 84/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 509 LLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q++TK + T L AA G V + +LL A + G + +H AA G+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
+ R+LL D I T LHVA G V + L ++G N + TPLH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR--ARQLV 685
I+ ++E+L + + A G T LH AS GH V+ +L R + +
Sbjct: 377 --IACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 686 DAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
+ K E T LH+AA H EVA+ L+ + + VN + + Q+PLH A + H +V LL
Sbjct: 434 NVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 746 VDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 777
++ + N G T LH+A + + ++A
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Score = 111 bits (278), Expect = 3e-24
Identities = 95/339 (28%), Positives = 152/339 (44%), Gaps = 15/339 (4%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N R ++LL + +D + G T L VA+++G + +++ LLQ A ++ + + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA E + LL + +A T LH A + G +V+ L E + NL
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G + + + E +T +GFT LH A+ G +L R
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLER 558
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+A ++G T LH+A +N+ ++ ++L+ G + +PLH+A +Q V
Sbjct: 559 DAH-PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG-YTPLHIAAKQNQVE 616
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQR---HQLLPLVADGAGGDPGPLQLLSRLQASG 797
+ L+ G S NAE +G T LH+A Q + L++ A G+ G L+ L
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L G V T G +PL +A+
Sbjct: 677 QEGH------VPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 108 bits (271), Expect = 2e-23
Identities = 108/383 (28%), Positives = 163/383 (42%), Gaps = 44/383 (11%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL R T G T L +A+ G V ++RLLL A ++ + T LH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
+ +LL G A + +H+A Q L+ VR L + +++ TPLH
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH- 343
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
++A G + +VL + + GFT LH A K H + V ++L + +DA
Sbjct: 344 -VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAV 400
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E G T LH+A+ H + + L++ G NV N K+++PLH+A + H + L+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRG-ASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 749 GCSVNAEDEEGDTALHVA-----------LQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
VNA+ ++ T LH A L + P +A AG P L +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP--------LHIAA 511
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCAQRFRERQA 856
G E V L E + T +G +PL +AA+ G+V A+ ER A
Sbjct: 512 REGHVE-----TVLALLEKEASQACMTK-KGFTPLHVAAKYGKV-----RVAELLLERDA 560
Query: 857 GGGAAPGPRQTLGTPNTVTNLHV 879
AA N +T LHV
Sbjct: 561 HPNAA--------GKNGLTPLHV 575
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/281 (30%), Positives = 130/281 (46%), Gaps = 7/281 (2%)
Query: 467 ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGR 524
ARE +AL + A ++ G + VA G A LL R G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L VA + +++++LLL P G T LH AA NQ E R LL G A+A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
+ T LH+A Q G E+V L + + NL + TPLH + A G + +VL
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH--LVAQEGHVPVADVLI 688
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ + V AT G+T LH AS G+ V K L + + V+AK + G++ LH AA H
Sbjct: 689 K-HGVMVDATTRMGYTPLHVASHYGNIKLV-KFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
++ +L++ G N + +PL +A + ++ + +L
Sbjct: 747 TDIVTLLLKNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 116 bits (290), Expect = 1e-25
Identities = 84/266 (31%), Positives = 129/266 (48%), Gaps = 5/266 (1%)
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
G+ L LL + Q +G T L VAA G+V + LLL+ A + G T L
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H A N + ++LL G + T LH+A ++ +EV R+L + G N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G A + +L++ N ++ N G T LH + +GH + V +L +
Sbjct: 634 QGVTPLHLAAQEGH-AEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGH-VPVADVLIK 689
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+VDA G+T LH+A+ + ++ + L++ + DVN + + SPLH A QQ H
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVA 766
+V LL+ G S N +G T L +A
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 115 bits (289), Expect = 2e-25
Identities = 111/360 (30%), Positives = 167/360 (46%), Gaps = 23/360 (6%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAG 548
+H L V G+ A LL + + G T L +A V ++ LLL+ A
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
+D + G T LH A+ + LL G + N T LH+A + G EV + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE---VPNIDVTATNSQGFTLLHHA 665
+ VN TPLH A A G + +V++L E PN+ TA G T LH A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCA--ARIGHTNMVKLLLENNANPNLATTA----GHTPLHIA 510
Query: 666 SLKGHALAVRKILAR-ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNR 724
+ +GH V +L + A Q KK GFT LH+AA VA++L+ E N +
Sbjct: 511 AREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLL-ERDAHPNAAGK 567
Query: 725 KLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAG 781
+PLH+AV ++ +V LL+ G S ++ G T LH+A +++Q+ L+ G
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 782 GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA-EGRV 840
+ +Q ++ L + G AE+ VA L+ + A+ + N G +PL L A EG V
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEM-----VALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHV 681
Score = 114 bits (284), Expect = 6e-25
Identities = 122/451 (27%), Positives = 182/451 (40%), Gaps = 92/451 (20%)
Query: 501 GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 559
GN +ALD LR + ++T NQ G L +A+ G V+++ LL ++ +GNTA
Sbjct: 23 GNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH AAL Q E R L++ G +A + T L++A Q LEVV+ L E G + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 620 AHSDTPLHSAISAG----------TGASGIVE------------------VLTEVPNIDV 651
TPL A+ G G G V +L PN DV
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 652 TA-------------------------------TNSQGFTLLHHASLKGHALAVRKILAR 680
+ T G T LH AS +G+ + VR +L R
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
Q ++ K +D T LH AA N H +++IL+ G + + + SP+H+A Q H+
Sbjct: 262 GAQ-IETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTKNGLSPIHMAAQGDHLD 319
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLLSRLQASGL 798
V LL+ ++ + T LHVA H++ ++ D G P + L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKP---------NSRAL 369
Query: 799 PGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRE 853
G L + V L GA + G +PL +A+ L ++ QR
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR--- 426
Query: 854 RQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
GA+P + T LH+ A G
Sbjct: 427 -----GASP----NVSNVKVETPLHMAARAG 448
Score = 112 bits (280), Expect = 2e-24
Identities = 84/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 509 LLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q++TK + T L AA G V + +LL A + G + +H AA G+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
+ R+LL D I T LHVA G V + L ++G N + TPLH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR--ARQLV 685
I+ ++E+L + + A G T LH AS GH V+ +L R + +
Sbjct: 377 --IACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 686 DAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
+ K E T LH+AA H EVA+ L+ + + VN + + Q+PLH A + H +V LL
Sbjct: 434 NVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 746 VDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 777
++ + N G T LH+A + + ++A
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Score = 111 bits (278), Expect = 3e-24
Identities = 95/339 (28%), Positives = 152/339 (44%), Gaps = 15/339 (4%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N R ++LL + +D + G T L VA+++G + +++ LLQ A ++ + + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA E + LL + +A T LH A + G +V+ L E + NL
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G + + + E +T +GFT LH A+ G +L R
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLER 558
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+A ++G T LH+A +N+ ++ ++L+ G + +PLH+A +Q V
Sbjct: 559 DAH-PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG-YTPLHIAAKQNQVE 616
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQR---HQLLPLVADGAGGDPGPLQLLSRLQASG 797
+ L+ G S NAE +G T LH+A Q + L++ A G+ G L+ L
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L G V T G +PL +A+
Sbjct: 677 QEGH------VPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 108 bits (271), Expect = 2e-23
Identities = 108/383 (28%), Positives = 163/383 (42%), Gaps = 44/383 (11%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL R T G T L +A+ G V ++RLLL A ++ + T LH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
+ +LL G A + +H+A Q L+ VR L + +++ TPLH
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH- 343
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
++A G + +VL + + GFT LH A K H + V ++L + +DA
Sbjct: 344 -VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAV 400
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E G T LH+A+ H + + L++ G NV N K+++PLH+A + H + L+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRG-ASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 749 GCSVNAEDEEGDTALHVA-----------LQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
VNA+ ++ T LH A L + P +A AG P L +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP--------LHIAA 511
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCAQRFRERQA 856
G E V L E + T +G +PL +AA+ G+V A+ ER A
Sbjct: 512 REGHVE-----TVLALLEKEASQACMTK-KGFTPLHVAAKYGKV-----RVAELLLERDA 560
Query: 857 GGGAAPGPRQTLGTPNTVTNLHV 879
AA N +T LHV
Sbjct: 561 HPNAA--------GKNGLTPLHV 575
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/281 (30%), Positives = 130/281 (46%), Gaps = 7/281 (2%)
Query: 467 ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGR 524
ARE +AL + A ++ G + VA G A LL R G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L VA + +++++LLL P G T LH AA NQ E R LL G A+A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
+ T LH+A Q G E+V L + + NL + TPLH + A G + +VL
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH--LVAQEGHVPVADVLI 688
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ + V AT G+T LH AS G+ V K L + + V+AK + G++ LH AA H
Sbjct: 689 K-HGVMVDATTRMGYTPLHVASHYGNIKLV-KFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
++ +L++ G N + +PL +A + ++ + +L
Sbjct: 747 TDIVTLLLKNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 116 bits (290), Expect = 1e-25
Identities = 84/266 (31%), Positives = 129/266 (48%), Gaps = 5/266 (1%)
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
G+ L LL + Q +G T L VAA G+V + LLL+ A + G T L
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H A N + ++LL G + T LH+A ++ +EV R+L + G N
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G A + +L++ N ++ N G T LH + +GH + V +L +
Sbjct: 634 QGVTPLHLAAQEGH-AEMVALLLSKQANGNLG--NKSGLTPLHLVAQEGH-VPVADVLIK 689
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+VDA G+T LH+A+ + ++ + L++ + DVN + + SPLH A QQ H
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTD 748
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVA 766
+V LL+ G S N +G T L +A
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 115 bits (289), Expect = 2e-25
Identities = 111/360 (30%), Positives = 167/360 (46%), Gaps = 23/360 (6%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAG 548
+H L V G+ A LL + + G T L +A V ++ LLL+ A
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 549 VDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL 608
+D + G T LH A+ + LL G + N T LH+A + G EV + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 609 CERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE---VPNIDVTATNSQGFTLLHHA 665
+ VN TPLH A A G + +V++L E PN+ TA G T LH A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCA--ARIGHTNMVKLLLENNANPNLATTA----GHTPLHIA 510
Query: 666 SLKGHALAVRKILAR-ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNR 724
+ +GH V +L + A Q KK GFT LH+AA VA++L+ E N +
Sbjct: 511 AREGHVETVLALLEKEASQACMTKK--GFTPLHVAAKYGKVRVAELLL-ERDAHPNAAGK 567
Query: 725 KLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAG 781
+PLH+AV ++ +V LL+ G S ++ G T LH+A +++Q+ L+ G
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 782 GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA-EGRV 840
+ +Q ++ L + G AE+ VA L+ + A+ + N G +PL L A EG V
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEM-----VALLLSKQ-ANGNLGNKSGLTPLHLVAQEGHV 681
Score = 114 bits (284), Expect = 6e-25
Identities = 122/451 (27%), Positives = 182/451 (40%), Gaps = 92/451 (20%)
Query: 501 GNAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTA 559
GN +ALD LR + ++T NQ G L +A+ G V+++ LL ++ +GNTA
Sbjct: 23 GNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH AAL Q E R L++ G +A + T L++A Q LEVV+ L E G + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 620 AHSDTPLHSAISAG----------TGASGIVE------------------VLTEVPNIDV 651
TPL A+ G G G V +L PN DV
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 652 TA-------------------------------TNSQGFTLLHHASLKGHALAVRKILAR 680
+ T G T LH AS +G+ + VR +L R
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
Q ++ K +D T LH AA N H +++IL+ G + + + SP+H+A Q H+
Sbjct: 262 GAQ-IETKTKDELTPLHCAARNGHVRISEILLDHG-APIQAKTKNGLSPIHMAAQGDHLD 319
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLLSRLQASGL 798
V LL+ ++ + T LHVA H++ ++ D G P + L
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD-KGAKP---------NSRAL 369
Query: 799 PGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRE 853
G L + V L GA + G +PL +A+ L ++ QR
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR--- 426
Query: 854 RQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
GA+P + T LH+ A G
Sbjct: 427 -----GASP----NVSNVKVETPLHMAARAG 448
Score = 112 bits (280), Expect = 2e-24
Identities = 84/272 (30%), Positives = 128/272 (47%), Gaps = 10/272 (3%)
Query: 509 LLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN 567
LL R Q++TK + T L AA G V + +LL A + G + +H AA G+
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 568 QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH 627
+ R+LL D I T LHVA G V + L ++G N + TPLH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 628 SAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR--ARQLV 685
I+ ++E+L + + A G T LH AS GH V+ +L R + +
Sbjct: 377 --IACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 686 DAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
+ K E T LH+AA H EVA+ L+ + + VN + + Q+PLH A + H +V LL
Sbjct: 434 NVKVE---TPLHMAARAGHTEVAKYLL-QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 746 VDAGCSVNAEDEEGDTALHVALQRHQLLPLVA 777
++ + N G T LH+A + + ++A
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Score = 111 bits (278), Expect = 3e-24
Identities = 95/339 (28%), Positives = 152/339 (44%), Gaps = 15/339 (4%)
Query: 502 NAARALDLLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL 560
N R ++LL + +D + G T L VA+++G + +++ LLQ A ++ + + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 561 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA 620
H AA E + LL + +A T LH A + G +V+ L E + NL
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 621 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR 680
TPLH A G + + + E +T +GFT LH A+ G +L R
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAKYGKVRVAELLLER 558
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
+A ++G T LH+A +N+ ++ ++L+ G + +PLH+A +Q V
Sbjct: 559 DAH-PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG-YTPLHIAAKQNQVE 616
Query: 741 LVPLLVDAGCSVNAEDEEGDTALHVALQR---HQLLPLVADGAGGDPGPLQLLSRLQASG 797
+ L+ G S NAE +G T LH+A Q + L++ A G+ G L+ L
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L G V T G +PL +A+
Sbjct: 677 QEGH------VPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 108 bits (271), Expect = 2e-23
Identities = 108/383 (28%), Positives = 163/383 (42%), Gaps = 44/383 (11%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL R T G T L +A+ G V ++RLLL A ++ + T LH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
+ +LL G A + +H+A Q L+ VR L + +++ TPLH
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH- 343
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
++A G + +VL + + GFT LH A K H + V ++L + +DA
Sbjct: 344 -VAAHCGHHRVAKVLLD-KGAKPNSRALNGFTPLHIACKKNH-VRVMELLLKTGASIDAV 400
Query: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
E G T LH+A+ H + + L++ G NV N K+++PLH+A + H + L+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRG-ASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 749 GCSVNAEDEEGDTALHVA-----------LQRHQLLPLVADGAGGDPGPLQLLSRLQASG 797
VNA+ ++ T LH A L + P +A AG P L +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP--------LHIAA 511
Query: 798 LPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCAQRFRERQA 856
G E V L E + T +G +PL +AA+ G+V A+ ER A
Sbjct: 512 REGHVE-----TVLALLEKEASQACMTK-KGFTPLHVAAKYGKV-----RVAELLLERDA 560
Query: 857 GGGAAPGPRQTLGTPNTVTNLHV 879
AA N +T LHV
Sbjct: 561 HPNAA--------GKNGLTPLHV 575
Score = 96.3 bits (238), Expect = 1e-19
Identities = 86/281 (30%), Positives = 130/281 (46%), Gaps = 7/281 (2%)
Query: 467 ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGR 524
ARE +AL + A ++ G + VA G A LL R G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGL 570
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L VA + +++++LLL P G T LH AA NQ E R LL G A+A
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
+ T LH+A Q G E+V L + + NL + TPLH + A G + +VL
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH--LVAQEGHVPVADVLI 688
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ + V AT G+T LH AS G+ V K L + + V+AK + G++ LH AA H
Sbjct: 689 K-HGVMVDATTRMGYTPLHVASHYGNIKLV-KFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLL 745
++ +L++ G N + +PL +A + ++ + +L
Sbjct: 747 TDIVTLLLKNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 114 bits (285), Expect = 5e-25
Identities = 91/312 (29%), Positives = 141/312 (45%), Gaps = 50/312 (16%)
Query: 502 NAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDE------ 555
N R +L+ RR + GR AL AA G + +RLLL+ A VD D
Sbjct: 27 NVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEA 86
Query: 556 ----GNTALHYAALGNQPEATRVLLSAGCR------------------------------ 581
G AL +A ++L+++G +
Sbjct: 87 RLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMED 146
Query: 582 -----ADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGA 636
D ++ TA H A + G L+ + L GCD N+ D +T LH ++AG G
Sbjct: 147 LEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH--LAAGRGH 204
Query: 637 SGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
+++ L ++ +D+ N++G T LH A+ H V ++L RA V+A + + L
Sbjct: 205 MAVLQRLVDI-GLDLEEQNAEGLTALHSAAGGSHPDCV-QLLLRAGSTVNALTQKNLSCL 262
Query: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
H AAL+ +V+++LI G C NV + + SPLHLAV+ LV LL+++ VNA D
Sbjct: 263 HYAALSGSEDVSRVLIHAGGC-ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD 321
Query: 757 EEGDTALHVALQ 768
T LH+A +
Sbjct: 322 NRQQTPLHLAAE 333
Score = 112 bits (280), Expect = 2e-24
Identities = 81/252 (32%), Positives = 129/252 (51%), Gaps = 7/252 (2%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLP--DDEGNTALHYAALGNQPEATRVLLSAGC 580
G T L AA G V ++ +++ V L D G TA H AA Q +A L+ +GC
Sbjct: 124 GLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGC 183
Query: 581 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 640
+ + +TALH+A RG + V++ L + G D+ +A T LHSA AG V
Sbjct: 184 DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSA--AGGSHPDCV 241
Query: 641 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAA 700
++L + V A + + LH+A+L G + V ++L A + G + LHLA
Sbjct: 242 QLLLRAGS-TVNALTQKNLSCLHYAALSG-SEDVSRVLIHAGGCANVVDHQGASPLHLAV 299
Query: 701 LNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGD 760
+N + ++LI DVN + + Q+PLHLA + A + +L+ AG +N D++G
Sbjct: 300 RHNFPALVRLLINSD-SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGK 358
Query: 761 TALHVALQRHQL 772
TAL VA++ + +
Sbjct: 359 TALAVAVRSNHV 370
Score = 79.3 bits (194), Expect = 2e-14
Identities = 61/227 (26%), Positives = 107/227 (47%), Gaps = 38/227 (16%)
Query: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCR 581
+G TAL +AA G + +++ L+ ++ + EG TALH AA G+ P+ ++LL AG
Sbjct: 191 EGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGST 250
Query: 582 ADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 641
+A+ + LH A G +V R L G N+ D +PLH A+
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAV----------- 299
Query: 642 VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAAL 701
+ + A+ ++L + V+A T LHLAA
Sbjct: 300 --------------------------RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAE 333
Query: 702 NNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDA 748
+ +++A +L+ G D+N+R+++ ++ L +AV+ HV LV +++ A
Sbjct: 334 HAWQDIADMLLIAG-VDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
Score = 75.5 bits (184), Expect = 2e-13
Identities = 52/161 (32%), Positives = 81/161 (50%), Gaps = 3/161 (1%)
Query: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCR 581
+G TAL AA + ++LLL+A + V+ + + LHYAAL + +RVL+ AG
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 582 ADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVE 641
A+ ++ ++ LH+AV+ F +VR L DVN D TPLH ++A I +
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLH--LAAEHAWQDIAD 341
Query: 642 VLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARAR 682
+L + +D+ + QG T L A H V I+ R
Sbjct: 342 MLL-IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADR 381
Score = 62.4 bits (150), Expect = 2e-09
Identities = 83/313 (26%), Positives = 116/313 (37%), Gaps = 70/313 (22%)
Query: 560 LHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 619
LH AA N + L+ A N ALH A G + VR L E V+ D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 620 AHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILA 679
A V LTE A G L ++ GH L + +IL
Sbjct: 79 A-------------------VGALTE-------ARLCFGMNALLLSAWFGH-LRILQILV 111
Query: 680 RARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKL-QSPLHLAVQQAH 738
+ + + +DG T LH AA H V ++ + KL ++ H A +
Sbjct: 112 NSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQ 171
Query: 739 VGLVPLLVDAGCSVNAEDEEGDTALHVA--------LQR-------------HQLLPLVA 777
+ + LV +GC N +D+EG+TALH+A LQR L L +
Sbjct: 172 LDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHS 231
Query: 778 DGAGGDPGPLQLLSR---------------LQASGLPGSAELTVGAAVACFLALEGADVS 822
G P +QLL R L + L GS + V+ L G +
Sbjct: 232 AAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSED------VSRVLIHAGGCAN 285
Query: 823 YTNHRGRSPLDLA 835
+H+G SPL LA
Sbjct: 286 VVDHQGASPLHLA 298
Score = 37.4 bits (85), Expect = 0.072
Identities = 26/85 (30%), Positives = 42/85 (49%)
Query: 521 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 580
+QG + L +A L+RLL+ + + V+ D+ T LH AA + +LL AG
Sbjct: 289 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGV 348
Query: 581 RADAINSTQSTALHVAVQRGFLEVV 605
+ + TAL VAV+ + +V
Sbjct: 349 DLNLRDKQGKTALAVAVRSNHVSLV 373
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 111 bits (278), Expect = 3e-24
Identities = 102/372 (27%), Positives = 154/372 (41%), Gaps = 47/372 (12%)
Query: 448 SCLVAYRPEEDANLDVAERARENKSS--LSVALDKLRAQKSDPEHPGRLVVE-------- 497
SC ++ R + N D+++ ++ S L AL + P + E
Sbjct: 309 SCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHF 368
Query: 498 -VALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEG 556
VA G+ + LL + G T L +AA Q +L LLL A + D++G
Sbjct: 369 LVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDG 428
Query: 557 NTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVN 616
LH+AA R+LL G DA T LH+A Q F V R L R D N
Sbjct: 429 WAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488
Query: 617 LPDAHSDTPLHSAISAGTGASGIVEVLT-EVPNIDV------------------------ 651
L +A TPLH ++A G +V++LT + +D
Sbjct: 489 LHEAEGKTPLH--VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHL 546
Query: 652 -------TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
A + G+ LH A+ +G L + K+L R ++ G+T LHLAA H
Sbjct: 547 LKSGAVPDALDQSGYGPLHTAAARGKYL-ICKMLLRYGASLELPTHQGWTPLHLAAYKGH 605
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH 764
E+ L+ E ++ +PLHLA + +V L+ G NA ++ G T LH
Sbjct: 606 LEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664
Query: 765 VALQRHQLLPLV 776
+A+QR L ++
Sbjct: 665 LAVQRSTFLSVI 676
Score = 107 bits (267), Expect = 6e-23
Identities = 92/312 (29%), Positives = 148/312 (47%), Gaps = 16/312 (5%)
Query: 483 AQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLL 542
AQ+ + P L + N AR L + R+ + + +G+T L VAAY G V L++LL
Sbjct: 456 AQEREGWTPLHLAAQNNFENVARLL--VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Query: 543 LQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFL 602
A +D T LH A + A + LL +G DA++ + LH A RG
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 603 EVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLL 662
+ + L G + LP TPLH ++A G I+ +L E + ++ A + +T L
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLH--LAAYKGHLEIIHLLAE-SHANMGALGAVNWTPL 630
Query: 663 HHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVR 722
H A+ G V +L +A ++ G+T LHLA + ++ I + E +V+ R
Sbjct: 631 HLAARHGEEAVVSALLQCGAD-PNAAEQSGWTPLHLA-VQRSTFLSVINLLEHHANVHAR 688
Query: 723 NRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ-RHQLL-------- 773
N+ +P HLA + + ++ +LV+AG ++ +D T L +AL+ R Q +
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE 748
Query: 774 PLVADGAGGDPG 785
P VA G PG
Sbjct: 749 PSVATLGGSKPG 760
Score = 97.1 bits (240), Expect = 8e-20
Identities = 96/308 (31%), Positives = 136/308 (44%), Gaps = 30/308 (9%)
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
I + T LH V +G +E VR L DV+ A TPL + A + L
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPL---LIAAQDQQPDLCALL 414
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
D + G+ LH A+ G R +L VDA++ +G+T LHLAA NN
Sbjct: 415 LAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGA-CVDAQEREGWTPLHLAAQNNF 473
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH 764
VA++L+ + D N+ + ++PLH+A HV LV LL G ++A+ T LH
Sbjct: 474 ENVARLLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLH 532
Query: 765 VALQRHQLLP---LVADGAGGDPGPLQLLSRLQASGL-PGSAELTVGAAVACFLALE-GA 819
+A++R ++ L+ GA D L SG P G + C + L GA
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDA--------LDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 820 DVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPNTVTNLHV 879
+ H+G +PL LAA L+ + A E A GA LG N T LH+
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLA----ESHANMGA-------LGAVNW-TPLHL 632
Query: 880 GAAPGPEA 887
A G EA
Sbjct: 633 AARHGEEA 640
Score = 63.5 bits (153), Expect = 9e-10
Identities = 75/279 (26%), Positives = 105/279 (37%), Gaps = 50/279 (17%)
Query: 445 FSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKS-----------DPEHPGR 493
F LV + A LD +R L+V K+RA + D G
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
Query: 494 LVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPD 553
L A G LLR +QG T L +AAY G +E+I LL ++ A +
Sbjct: 564 LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALG 623
Query: 554 DEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRG-FLEVVRALCERG 612
T LH AA + LL G +A + T LH+AVQR FL V
Sbjct: 624 AVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSV-------- 675
Query: 613 CDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHAL 672
+NL + H++ V A N G+T H A+LKG+
Sbjct: 676 --INLLEHHAN---------------------------VHARNKVGWTPAHLAALKGNT- 705
Query: 673 AVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQIL 711
A+ K+L A +D + T L LA + + + L
Sbjct: 706 AILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 62.0 bits (149), Expect = 3e-09
Identities = 57/206 (27%), Positives = 89/206 (43%), Gaps = 17/206 (8%)
Query: 646 VPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHR 705
VP + T LH +G VR +LA VD + G+T L +AA +
Sbjct: 350 VPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVD-VDCQTASGYTPLLIAAQDQQP 408
Query: 706 EVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHV 765
++ +L+ G D N + +PLH A Q G LL+D G V+A++ EG T LH+
Sbjct: 409 DLCALLLAHG-ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHL 467
Query: 766 ALQRH-QLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGA-----AVACFLALEGA 819
A Q + + + + DP + G L V A ++ L +GA
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEA---------EGKTPLHVAAYFGHVSLVKLLTSQGA 518
Query: 820 DVSYTNHRGRSPLDLAAEGRVLKALQ 845
++ R+PL LA E ++A+Q
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQ 544
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 109 bits (272), Expect = 1e-23
Identities = 117/395 (29%), Positives = 170/395 (43%), Gaps = 41/395 (10%)
Query: 530 AAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQ 589
A + VE +R LL + +++ D E T LH AA ++LL +G +A ++
Sbjct: 15 AIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLW 74
Query: 590 STALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNI 649
T LH A +V+ L DVN D TPLH ++A A+ E L + +
Sbjct: 75 LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLH--VAAANRATKCAEALAPLLS- 131
Query: 650 DVTATNSQGFTLLHHASLKGHALAVRKILARARQL-VDAKKEDGFTALHLAALNNHREVA 708
+ + G + LHHA GH V +L + L V KKE LH AA H EV
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKER--QPLHWAAFLGHLEVL 189
Query: 709 QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
++L+ G D+ ++RK LH A + +V L+ G ++ + G+TALH+A
Sbjct: 190 KLLVARG-ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248
Query: 769 RHQ---LLPLVADGAG----GDPG--PLQLLSRLQASGLPGSAELTVGAAVACFLALEGA 819
Q + LV GA D G PL + +A T GA L GA
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHV-----------AAVSTNGALCLELLVNNGA 297
Query: 820 DVSYTNHRGRSPLDLAA-EGRVLKA---LQG-----CAQRFRERQAGGGAAPGPRQTLGT 870
DV+Y + G+SPL +AA GR ++ +Q CA +F A G + T
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 871 PNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPC 905
+TN GA + LA+L FS C
Sbjct: 358 --LMTN---GADTARRGIHDMFPLHLAVLFGFSDC 387
Score = 100 bits (248), Expect = 9e-21
Identities = 115/392 (29%), Positives = 163/392 (41%), Gaps = 52/392 (13%)
Query: 472 SSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAA 531
SSL+VA R+ H G L L N +L++ ++ Q L AA
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ---------PLHWAA 181
Query: 532 YLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQST 591
+LG +E+++LL+ A + D +G LH AA Q E + LL G D N+ +T
Sbjct: 182 FLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNT 241
Query: 592 ALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDV 651
ALH+A G V L G +VN P+ TPLH A + GA +E+L DV
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVN-NGADV 299
Query: 652 TATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQIL 711
+ +G + LH A++ G +IL + +D + G T LH+AA H + L
Sbjct: 300 NYQSKEGKSPLHMAAIHGR-FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Query: 712 IREGRCDVNVRNRKLQSPLHLAV--------------QQAHVGLVPL----LVDAGCSVN 753
+ G D R PLHLAV Q + + L ++ AG +N
Sbjct: 359 MTNG-ADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417
Query: 754 AEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLL----SRLQASGLPGSAELTVGAA 809
D G T LH A +GG+ L LL + L+ G L AA
Sbjct: 418 TPDNLGRTCLHAA------------ASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAA 465
Query: 810 -----VACFLALEGADVSYTNHRGRSPLDLAA 836
A L GA V+ + +G SPL AA
Sbjct: 466 NGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497
Score = 86.3 bits (212), Expect = 1e-16
Identities = 93/337 (27%), Positives = 141/337 (41%), Gaps = 31/337 (9%)
Query: 446 SPSCLVAYRPEEDANLDVAER-----ARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL 500
SP L AY +A +AE R++K ++ L R VEV
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTE--------CVEVLT 638
Query: 501 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQA--RAGV-DLPDDEGN 557
+ A AL R+R T L AA G + + LL+ + RA + D+ D G
Sbjct: 639 AHGASALIKERKRKW---------TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
Query: 558 TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNL 617
T L A + + +LL G ADA + TALH G + + AL + V
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 749
Query: 618 PDAHSDTPLHSAISAGTGA--SGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 675
D TP+H A + G A +++ +D + G++ +H AS GH +
Sbjct: 750 RDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD-AGVDYSGYSPMHWASYTGHEDCLE 808
Query: 676 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE-GRCDVNVRNRKLQSPLHLAV 734
+L + + + FT LH A +NN ++L+ G VN R+ K ++PLH A
Sbjct: 809 LLLEHSP--FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866
Query: 735 QQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQ 771
+V + +L+ VNA D G TAL A + Q
Sbjct: 867 FADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
Score = 85.9 bits (211), Expect = 2e-16
Identities = 77/249 (30%), Positives = 113/249 (45%), Gaps = 14/249 (5%)
Query: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDD----EGNTALHYAALGNQPEATRVLLS 577
+GRT + +A+ G ++R LLQA D D G + +H+A+ + +LL
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Query: 578 AGCRADAINSTQSTALHVAV---QRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGT 634
+ T LH AV Q E++ VN DA TPLH+A A
Sbjct: 813 HS-PFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKGRTPLHAAAFADN 870
Query: 635 GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFT 694
SG+ +L +V AT+ G T L A+ G AV +L R + + E+ T
Sbjct: 871 -VSGLRMLLQH--QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNT 927
Query: 695 ALHLAALNNHREVAQILIREGRCD--VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSV 752
ALHLA H + A +++ E + +N N LQ PLH+A + +V L+ G +V
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Query: 753 NAEDEEGDT 761
A DEEG T
Sbjct: 988 LAVDEEGHT 996
Score = 80.5 bits (197), Expect = 7e-15
Identities = 103/407 (25%), Positives = 165/407 (40%), Gaps = 62/407 (15%)
Query: 499 ALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGN 557
A AL L +D ++ +GRTAL +A G E + +L A + + +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
Query: 558 -TALHYAALGNQPEATRVLLSAGCRAD---AINSTQSTALHVAVQRGFLEVVRALCERGC 613
T LH AA ++ +L+ +G RAD +++ T L +A+ G ++ V L E+G
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 614 DVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALA 673
+ D T LH A TG + L + + V + +G T +H AS GH
Sbjct: 713 TADAADLRGRTALHRG--AVTGCEDCLAALLD-HDAFVLCRDFKGRTPIHLASACGHTAV 769
Query: 674 VRKILARARQL--VDAKKE-DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPL 730
+R +L A +DA + G++ +H A+ H + ++L+ N +PL
Sbjct: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF--TPL 827
Query: 731 HLAVQQAHVGLVPLLVDA--GCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQ 788
H AV +L+ A VN+ D +G T LH A AD G L+
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA--------FADNVSG----LR 875
Query: 789 LLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCA 848
+L + QA +V+ T+H GR+ L AAE A++
Sbjct: 876 MLLQHQA------------------------EVNATDHTGRTALMTAAENGQTAAVEFLL 911
Query: 849 QRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSE 895
R G A T+ N T LH+ + G E ++ +E
Sbjct: 912 YR--------GKAD---LTVLDENKNTALHLACSKGHEKCALMILAE 947
Score = 74.3 bits (181), Expect = 5e-13
Identities = 76/261 (29%), Positives = 111/261 (42%), Gaps = 51/261 (19%)
Query: 539 IRLLLQARAGVDLPDDEGNTALHY-AALGNQPEATRVL-LSAGCRADAINSTQSTALHVA 596
+ LL A L D +G TA+HY AA GN+ +L +S C D ++ + LH+A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 597 VQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNS 656
G E ++ L E ++++ D T L ++ G++ VEVLT
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALF--LATERGSTECVEVLT------------ 638
Query: 657 QGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREG- 715
H AS L+ +K +T LH AA + H + +LI G
Sbjct: 639 -----AHGAS----------------ALIKERKRK-WTPLHAAAASGHTDSLHLLIDSGE 676
Query: 716 RCDV-NVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH---------- 764
R D+ +V + Q+PL LA+ HV V LL++ G + +A D G TALH
Sbjct: 677 RADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDC 736
Query: 765 -VALQRHQLLPLVADGAGGDP 784
AL H L D G P
Sbjct: 737 LAALLDHDAFVLCRDFKGRTP 757
Score = 73.6 bits (179), Expect = 9e-13
Identities = 90/356 (25%), Positives = 140/356 (39%), Gaps = 63/356 (17%)
Query: 542 LLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGF 601
+L A ++ PD+ G T LH AA G E +LLS+G + T LH A G
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 602 LEVVRALCERGCDVNLPDAHSDTPLHSAISAGT--------------------------G 635
+ L G VN D +PLH A ++ T
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528
Query: 636 ASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARA-RQLVDAKKEDGFT 694
A +E L + D + + QG+T +H+A+ G+ + +L + L D + +
Sbjct: 529 AFFCLEFLLD-NGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVS 587
Query: 695 ALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS--- 751
LHLAA N H E + L E +++VR+ K ++ L LA ++ V +L G S
Sbjct: 588 PLHLAAYNGHCEALKTL-AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 752 ---------VNAEDEEGDT-ALHVALQRHQLLPL--VADGAGGDPGPLQLL--------- 790
++A G T +LH+ + + + V D G P L ++
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
Query: 791 -----SRLQASGLPGSAELTVGAAVAC-----FLALEGADVSYTNHRGRSPLDLAA 836
S A+ L G L GA C L A V + +GR+P+ LA+
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLAS 762
Score = 67.4 bits (163), Expect = 6e-11
Identities = 81/282 (28%), Positives = 130/282 (46%), Gaps = 35/282 (12%)
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLT 644
++ T L A+ +E VR+L + ++N+ D TPLH+A A G I+++L
Sbjct: 4 LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAA--AYVGDVPILQLLL 61
Query: 645 EVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNH 704
+ +V A ++ T LH A+ + + +LA + V+A+ + T LH+AA N
Sbjct: 62 -MSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD-VNARDKLWQTPLHVAAANRA 119
Query: 705 REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALH 764
+ A+ L +NV +R +S LH AV H+ V LL++ G S+N D++ LH
Sbjct: 120 TKCAEAL-APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLH 178
Query: 765 VA--LQRHQLLPLV----ADGAGGDPGPLQLLSRLQASG--------LPGSAEL------ 804
A L ++L L+ AD D LL ASG L AE+
Sbjct: 179 WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
Query: 805 -TVGAAVACFLALE---------GADVSYTNHRGRSPLDLAA 836
+AC+L + GA+V+ N +G +PL +AA
Sbjct: 239 GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAA 280
Score = 66.6 bits (161), Expect = 1e-10
Identities = 68/240 (28%), Positives = 103/240 (42%), Gaps = 9/240 (3%)
Query: 522 QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGN---TALHYAALGNQPEATRVLLSA 578
QG TA+ AA G + + LLL+ L D E + LH AA EA + L
Sbjct: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSD-TPLHSAISAGTGAS 637
D + TAL +A +RG E V L G + + TPLH+A ++G
Sbjct: 608 LVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASG-HTD 666
Query: 638 GIVEVLTEVPNIDVT-ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
+ ++ D+T ++ G T L A + GH V +L + DA G TAL
Sbjct: 667 SLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG-STADAADLRGRTAL 725
Query: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
H A+ + L+ + V R+ K ++P+HLA H ++ L+ A S + D
Sbjct: 726 HRGAVTGCEDCLAALL-DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 784
Score = 60.1 bits (144), Expect = 1e-08
Identities = 50/164 (30%), Positives = 74/164 (45%), Gaps = 5/164 (3%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLL-QARAGVDLPDDEGNTALHYAALGN 567
LL+ + E T + GRTAL AA GQ + LL + +A + + D+ NTALH A
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
Query: 568 QPEATRVLLSAGCRADAINSTQST---ALHVAVQRGFLEVVRALCERGCDVNLPDAHSDT 624
+ ++L+ IN+T S LH+A + G VV+AL G V D T
Sbjct: 937 HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
Query: 625 PLHSAISAGTGASGIVEVL-TEVPNIDVTATNSQGFTLLHHASL 667
P + A + +L T P A + F+LL + S+
Sbjct: 997 PALACAPNKDVADCLALILSTMKPFPPKDAVSPFSFSLLKNCSI 1040
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 108 bits (269), Expect = 3e-23
Identities = 79/241 (32%), Positives = 118/241 (48%), Gaps = 6/241 (2%)
Query: 493 RLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLP 552
RL+V G + L+ + TK+ GRT L +AA G + ++++LL+A +D+
Sbjct: 13 RLLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
Query: 553 DDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERG 612
DD TALH A + E L+ GC D + +TALH A GF + + L + G
Sbjct: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
Query: 613 CDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHAL 672
+V + +T LH A S V +L N+ G T LH A+ H L
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLA---GSRADLKNNAGDTCLHVAARYNH-L 187
Query: 673 AVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHL 732
++ ++L A V K + G TALH+AA NH++VA+IL+ G D + N Q+PL
Sbjct: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG-ADTTIVNNAGQTPLET 246
Query: 733 A 733
A
Sbjct: 247 A 247
Score = 108 bits (269), Expect = 3e-23
Identities = 79/240 (32%), Positives = 110/240 (45%), Gaps = 6/240 (2%)
Query: 527 LQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAIN 586
L VAAY GQ E + L+ A V + G T LH AA ++LL AGC D +
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 587 STQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV 646
TALH A G E++ AL GC ++ D +T LH A G S + V
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA-- 130
Query: 647 PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHRE 706
+V A N G T LH A H+ + R +L A D K G T LH+AA NH
Sbjct: 131 -GANVLAKNKAGNTALHLACQNSHSQSTR-VLLLAGSRADLKNNAGDTCLHVAARYNHLS 188
Query: 707 VAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVA 766
+ ++L+ C V+ +N+ + LH+A H + +L++AG + G T L A
Sbjct: 189 IIRLLLT-AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Score = 105 bits (263), Expect = 2e-22
Identities = 76/222 (34%), Positives = 117/222 (52%), Gaps = 7/222 (3%)
Query: 563 AALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHS 622
AA Q E L++ G R A+ T LH+A +G L VV+ L + GCD+++ D
Sbjct: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
Query: 623 DTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARAR 682
T LH A G I ++ E +D + G T LH AS G + + K+L +A
Sbjct: 76 QTALHRATVVGN-TEIIAALIHEGCALD--RQDKDGNTALHEASWHGFSQSA-KLLVKAG 131
Query: 683 QLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLV 742
V AK + G TALHLA N+H + ++L+ G +++N + LH+A + H+ ++
Sbjct: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGS-RADLKNNAGDTCLHVAARYNHLSII 190
Query: 743 PLLVDAGCSVNAEDEEGDTALHVALQ-RHQLLPLVADGAGGD 783
LL+ A CSV+ +++ GDTALHVA H+ + + AG D
Sbjct: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
Score = 83.2 bits (204), Expect = 1e-15
Identities = 57/163 (34%), Positives = 84/163 (51%), Gaps = 4/163 (2%)
Query: 523 GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRA 582
G TAL A++ G + +LL++A A V + GNTALH A + ++TRVLL AG RA
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
Query: 583 DAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEV 642
D N+ T LHVA + L ++R L C V+ + DT LH ++A + ++
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALH--VAAALNHKKVAKI 225
Query: 643 LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLV 685
L E D T N+ G T L A + V +L +A Q++
Sbjct: 226 LLEA-GADTTIVNNAGQTPLETARYHNNP-EVALLLTKAPQVL 266
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 107 bits (266), Expect = 7e-23
Identities = 80/247 (32%), Positives = 125/247 (50%), Gaps = 8/247 (3%)
Query: 521 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDD-EGNTALHYAALGNQPEATRVLLSAG 579
N RT L AA LG +++ LLL+ +P D +G T LHYAA N E +V L
Sbjct: 253 NLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
Query: 580 CRADAINSTQSTALHVAVQRGFLEVVRALC--ERGCDVNLPDAHSDTPLHSAISAGTGAS 637
D + T+ A +G +V+R + + D+N+ D + T LH+A A +G
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAA--ALSGHV 370
Query: 638 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
V++L E N V AT+ T L A GH ++ ++ + VD +DG + LH
Sbjct: 371 STVKLLLE-NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR-VDLVDQDGHSLLH 428
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
AAL + +V QILI E + + NV++ ++PL A ++ + +L++ N +D+
Sbjct: 429 WAALGGNADVCQILI-ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Query: 758 EGDTALH 764
EG TALH
Sbjct: 488 EGRTALH 494
Score = 99.4 bits (246), Expect = 2e-20
Identities = 101/352 (28%), Positives = 161/352 (45%), Gaps = 23/352 (6%)
Query: 506 ALDLLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAA 564
AL L P +VDT+++ + TAL +AY E ++LL++ + + +PD EG LH+AA
Sbjct: 131 ALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA 190
Query: 565 LGNQPEAT---RVLLSAGCRADAINSTQ---STALHVAVQRGFLEVVRALCE-RGCDVNL 617
P A R +L A +N T LH AV G + VV L C++
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 618 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 677
D TPLH A A G + IV +L E ++SQG T LH+A+ A V K+
Sbjct: 251 YDNLFRTPLHWA--ALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETV-KV 307
Query: 678 LARARQLVDAKKEDGFTALHLAALNNHREVAQILIR-EGRCDVNVRNRKLQSPLHLAVQQ 736
+ + D +G T+ AA +V + ++ + D+N+ ++ + LH A
Sbjct: 308 FLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
Query: 737 AHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ---RHQLLPLVADGAGGDPGPLQLLSRL 793
HV V LL++ V+A D T L A + + + L+ GA D S L
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
Query: 794 QASGLPGSAELTVGAAVACFLALEG-ADVSYTNHRGRSPLDLAAEGRVLKAL 844
+ L G+A++ C + +E + + ++ GR+PL AA G + +
Sbjct: 428 HWAALGGNADV-------CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/287 (24%), Positives = 125/287 (43%), Gaps = 45/287 (15%)
Query: 499 ALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDL--PDDE 555
A N A + + + P D + +GRT+ AA G +++R +L ++ +D+ D
Sbjct: 297 AQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY 356
Query: 556 GNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDV 615
G TALH AAL ++LL + DA + + T L A + G +V++ L + G V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 616 NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 675
+L D G +LLH A+L G+A V
Sbjct: 417 DLVD------------------------------------QDGHSLLHWAALGGNA-DVC 439
Query: 676 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 735
+IL + + + G T L AA + +L+ E D N+++++ ++ LH +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-ENNADPNIQDKEGRTALHWSCN 498
Query: 736 QAHVGLVPLLVDAGCSVN--AEDEEGDTALHVAL--QRHQLLPLVAD 778
++ + LL+D N +EE T L AL +RH+++ + +
Sbjct: 499 NGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Score = 64.3 bits (155), Expect = 6e-10
Identities = 67/269 (24%), Positives = 105/269 (39%), Gaps = 38/269 (14%)
Query: 538 LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAV 597
L RL++ A D D G T L Y L ++ + LL AG + + +Q TALH+A
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 598 QRGFLEVVRALCERGCDVNLPDAHSDTPLH----------SAISAGTGASGIVEV----- 642
Q+G ++ L R + D TPLH A+ A G V+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK 149
Query: 643 -----------------LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI-----LAR 680
L + ++ + +G LH A+ AV + A
Sbjct: 150 QTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAP 209
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
L++ + +G T LH A + + V +L C++ + ++PLH A H
Sbjct: 210 TESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 741 LVPLLVDAGCS-VNAEDEEGDTALHVALQ 768
+V LL++ S D +G T LH A Q
Sbjct: 270 IVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 1/146 (0%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVD-TKNQGRTALQVAAYLGQVELIRLLLQARA 547
++ G + AL + LL QVD T T L A +G ++I+ L++ A
Sbjct: 355 KYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 548 GVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRA 607
VDL D +G++ LH+AALG + ++L+ + + T L A G++ +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 608 LCERGCDVNLPDAHSDTPLHSAISAG 633
L E D N+ D T LH + + G
Sbjct: 475 LMENNADPNIQDKEGRTALHWSCNNG 500
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/225 (26%), Positives = 99/225 (44%), Gaps = 30/225 (13%)
Query: 560 LHYAAL-GNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLP 618
+H AA+ G++ R+++ D + T L V L+ AL + G DVN
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 619 DAHSDTPLHSAISAGT----------GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLK 668
D T LH A G A+ + + L E+ + +T H S K
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT---------RHRSPK 128
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
AL + K +A VD + ++ TALH +A N+ E ++LI+ ++ + + + +
Sbjct: 129 CLALLL-KFMAPGE--VDTQDKNKQTALHWSAYYNNPEHVKLLIKHD-SNIGIPDVEGKI 184
Query: 729 PLHLAVQQ---AHVGLVPLLVDAGCS---VNAEDEEGDTALHVAL 767
PLH A + V V ++DA + +N +D EG T LH A+
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAV 229
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 107 bits (266), Expect = 7e-23
Identities = 80/247 (32%), Positives = 125/247 (50%), Gaps = 8/247 (3%)
Query: 521 NQGRTALQVAAYLGQVELIRLLLQARAGVDLPDD-EGNTALHYAALGNQPEATRVLLSAG 579
N RT L AA LG +++ LLL+ +P D +G T LHYAA N E +V L
Sbjct: 253 NLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHP 312
Query: 580 CRADAINSTQSTALHVAVQRGFLEVVRALC--ERGCDVNLPDAHSDTPLHSAISAGTGAS 637
D + T+ A +G +V+R + + D+N+ D + T LH+A A +G
Sbjct: 313 SVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAA--ALSGHV 370
Query: 638 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
V++L E N V AT+ T L A GH ++ ++ + VD +DG + LH
Sbjct: 371 STVKLLLE-NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR-VDLVDQDGHSLLH 428
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
AAL + +V QILI E + + NV++ ++PL A ++ + +L++ N +D+
Sbjct: 429 WAALGGNADVCQILI-ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487
Query: 758 EGDTALH 764
EG TALH
Sbjct: 488 EGRTALH 494
Score = 99.4 bits (246), Expect = 2e-20
Identities = 101/352 (28%), Positives = 161/352 (45%), Gaps = 23/352 (6%)
Query: 506 ALDLLRRRPEQVDTKNQGR-TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAA 564
AL L P +VDT+++ + TAL +AY E ++LL++ + + +PD EG LH+AA
Sbjct: 131 ALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA 190
Query: 565 LGNQPEAT---RVLLSAGCRADAINSTQ---STALHVAVQRGFLEVVRALCE-RGCDVNL 617
P A R +L A +N T LH AV G + VV L C++
Sbjct: 191 NHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITS 250
Query: 618 PDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI 677
D TPLH A A G + IV +L E ++SQG T LH+A+ A V K+
Sbjct: 251 YDNLFRTPLHWA--ALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETV-KV 307
Query: 678 LARARQLVDAKKEDGFTALHLAALNNHREVAQILIR-EGRCDVNVRNRKLQSPLHLAVQQ 736
+ + D +G T+ AA +V + ++ + D+N+ ++ + LH A
Sbjct: 308 FLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
Query: 737 AHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ---RHQLLPLVADGAGGDPGPLQLLSRL 793
HV V LL++ V+A D T L A + + + L+ GA D S L
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
Query: 794 QASGLPGSAELTVGAAVACFLALEG-ADVSYTNHRGRSPLDLAAEGRVLKAL 844
+ L G+A++ C + +E + + ++ GR+PL AA G + +
Sbjct: 428 HWAALGGNADV-------CQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/287 (24%), Positives = 125/287 (43%), Gaps = 45/287 (15%)
Query: 499 ALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDL--PDDE 555
A N A + + + P D + +GRT+ AA G +++R +L ++ +D+ D
Sbjct: 297 AQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKY 356
Query: 556 GNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDV 615
G TALH AAL ++LL + DA + + T L A + G +V++ L + G V
Sbjct: 357 GGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARV 416
Query: 616 NLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVR 675
+L D G +LLH A+L G+A V
Sbjct: 417 DLVD------------------------------------QDGHSLLHWAALGGNA-DVC 439
Query: 676 KILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQ 735
+IL + + + G T L AA + +L+ E D N+++++ ++ LH +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM-ENNADPNIQDKEGRTALHWSCN 498
Query: 736 QAHVGLVPLLVDAGCSVN--AEDEEGDTALHVAL--QRHQLLPLVAD 778
++ + LL+D N +EE T L AL +RH+++ + +
Sbjct: 499 NGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLE 545
Score = 64.3 bits (155), Expect = 6e-10
Identities = 67/269 (24%), Positives = 105/269 (39%), Gaps = 38/269 (14%)
Query: 538 LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAV 597
L RL++ A D D G T L Y L ++ + LL AG + + +Q TALH+A
Sbjct: 30 LQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAA 89
Query: 598 QRGFLEVVRALCERGCDVNLPDAHSDTPLH----------SAISAGTGASGIVEV----- 642
Q+G ++ L R + D TPLH A+ A G V+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK 149
Query: 643 -----------------LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKI-----LAR 680
L + ++ + +G LH A+ AV + A
Sbjct: 150 QTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAP 209
Query: 681 ARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
L++ + +G T LH A + + V +L C++ + ++PLH A H
Sbjct: 210 TESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 741 LVPLLVDAGCS-VNAEDEEGDTALHVALQ 768
+V LL++ S D +G T LH A Q
Sbjct: 270 IVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 1/146 (0%)
Query: 489 EHPGRLVVEVALGNAARALDLLRRRPEQVD-TKNQGRTALQVAAYLGQVELIRLLLQARA 547
++ G + AL + LL QVD T T L A +G ++I+ L++ A
Sbjct: 355 KYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGA 414
Query: 548 GVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRA 607
VDL D +G++ LH+AALG + ++L+ + + T L A G++ +
Sbjct: 415 RVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAV 474
Query: 608 LCERGCDVNLPDAHSDTPLHSAISAG 633
L E D N+ D T LH + + G
Sbjct: 475 LMENNADPNIQDKEGRTALHWSCNNG 500
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/225 (26%), Positives = 99/225 (44%), Gaps = 30/225 (13%)
Query: 560 LHYAAL-GNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLP 618
+H AA+ G++ R+++ D + T L V L+ AL + G DVN
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 619 DAHSDTPLHSAISAGT----------GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLK 668
D T LH A G A+ + + L E+ + +T H S K
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT---------RHRSPK 128
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
AL + K +A VD + ++ TALH +A N+ E ++LI+ ++ + + + +
Sbjct: 129 CLALLL-KFMAPGE--VDTQDKNKQTALHWSAYYNNPEHVKLLIKHD-SNIGIPDVEGKI 184
Query: 729 PLHLAVQQ---AHVGLVPLLVDAGCS---VNAEDEEGDTALHVAL 767
PLH A + V V ++DA + +N +D EG T LH A+
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAV 229
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 103 bits (257), Expect = 8e-22
Identities = 101/312 (32%), Positives = 132/312 (42%), Gaps = 22/312 (7%)
Query: 465 ERARENKSSLSVALDKLRAQKSDPEHP------GRLVVEVALGNAARALDLLRRRPEQVD 518
E E + + LD A + E P G L+ V G A LLR+ +
Sbjct: 10 EEEEEEQELRWMELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEE 69
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
+ GRT L +A G L+RLLLQ A V D G TALH AA +LL
Sbjct: 70 RDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQR 129
Query: 579 GCRADAINSTQSTALHVAVQRGFLEVVRALCER----GCDVNLPDAHSDTPLHSAISAGT 634
G A A + T T LH A G + L E DA T H A A
Sbjct: 130 GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWA--AAG 187
Query: 635 GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFT 694
G ++E+L G L+ A+ G A+R +LAR + VDA+ G T
Sbjct: 188 GRLAVLELLA------AGGAGLDGALLV--AAAAGRGAALRFLLARGAR-VDARDGAGAT 238
Query: 695 ALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNA 754
AL LAA + ++L+ G D +R+R +S LH A + H+ V LLV G V+A
Sbjct: 239 ALGLAAALGRSQDIEVLLGHG-ADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDA 297
Query: 755 EDEEGDTALHVA 766
D G T LH A
Sbjct: 298 RDTLGLTPLHHA 309
Score = 95.1 bits (235), Expect = 3e-19
Identities = 109/367 (29%), Positives = 156/367 (42%), Gaps = 32/367 (8%)
Query: 428 VFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVA-----LDKLR 482
V G G+L AV W P+ LV + A+++ + A L+V L +L
Sbjct: 39 VQGWGHLLQAV----WR-GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLL 93
Query: 483 AQKSDP----EHPGRLVVEVAL--GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQV 536
Q+ P + GR + A G++ A LL+R G T L AA LG
Sbjct: 94 LQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHT 153
Query: 537 ELIRLLLQAR----AGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTA 592
L LL+A A + D G TA H+AA G + +L + G D A
Sbjct: 154 LLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG-------A 206
Query: 593 LHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVT 652
L VA G +R L RG V+ D T L ++A G S +EVL D
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATAL--GLAAALGRSQDIEVLLG-HGADPG 263
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
+ G + LH A+ +GH LAV+ ++ + + VDA+ G T LH A+ H EVA L+
Sbjct: 264 IRDRHGRSALHRAAARGHLLAVQLLVTQGAE-VDARDTLGLTPLHHASREGHVEVAGCLL 322
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQL 772
G V+ ++PLHLA ++ H V LL+ G S + + A Q
Sbjct: 323 DRG-AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQMPEGDLPQA 381
Query: 773 LPLVADG 779
LP + G
Sbjct: 382 LPELGGG 388
Score = 73.6 bits (179), Expect = 9e-13
Identities = 90/286 (31%), Positives = 120/286 (41%), Gaps = 43/286 (15%)
Query: 635 GASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFT 694
G +G+V L V + G T LH A L+GHA VR +L R V A G T
Sbjct: 52 GPAGLVTQLLR-QGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP-VGAVDRAGRT 109
Query: 695 ALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG----C 750
ALH AA + H VA++L++ G R+ +PLH A H L L++A
Sbjct: 110 ALHEAAWHGHSRVAELLLQRG-ASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPA 168
Query: 751 SVNAEDEEGDTALHVALQ--RHQLLPLVADGAGGDPGPLQLL----------------SR 792
+ AED G TA H A R +L L+A G G G L + +R
Sbjct: 169 AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGAR 228
Query: 793 LQASGLPGSAELTVGAAVACFLALE-----GADVSYTNHRGRSPLDLAAEGRVLKALQGC 847
+ A G+ L + AA+ +E GAD + GRS L AA L A+Q
Sbjct: 229 VDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
Query: 848 AQRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG-PEAAECLV 892
+ GA R TLG +T LH + G E A CL+
Sbjct: 289 VTQ--------GAEVDARDTLG----LTPLHHASREGHVEVAGCLL 322
Score = 31.6 bits (70), Expect = 4.0
Identities = 47/156 (30%), Positives = 58/156 (37%), Gaps = 19/156 (12%)
Query: 733 AVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR-HQLLPLVADGAGGDPGPLQLLS 791
AV + GLV L+ G SV D G T LH+A+ R H L + G G +
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 792 R--LQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKALQGCA 848
R L + G + VA L GA + + G +PL AA G L A
Sbjct: 108 RTALHEAAWHGHSR------VAELLLQRGASAAARSGTGLTPLHWAAALGHTL-----LA 156
Query: 849 QRFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPG 884
R E G AA G T H AA G
Sbjct: 157 ARLLEAPGPGPAAAEAEDARGW----TAAHWAAAGG 188
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 102 bits (254), Expect = 2e-21
Identities = 101/350 (28%), Positives = 159/350 (45%), Gaps = 34/350 (9%)
Query: 449 CLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALD 508
C+V + D N+ R + KS+L +A +A + L+ GN + +
Sbjct: 298 CIVLLQHGADPNI----RNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA 353
Query: 509 LLRRRPEQVDTK-NQGR--TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAAL 565
LL P V+ + GR T L +AA +V +++LLLQ A V D G LH A
Sbjct: 354 LLT--PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411
Query: 566 GNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTP 625
E T +LL G +A++ Q T LH A + +EV L G D L + H +
Sbjct: 412 YGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSA 471
Query: 626 LHSAISAGTGASGIVEVLTEVPNIDVTAT-NSQGFTLLHHASLKGHALAVRKILARARQL 684
+ A P + T +G +LL A+ + V+K L A ++
Sbjct: 472 VDMA---------------PTPELRERLTYEFKGHSLL-QAAREADLAKVKKTL--ALEI 513
Query: 685 VDAKKEDGF-TALHLAALNNH---REVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVG 740
++ K+ TALH A + H ++V ++L+R+G +VN +N+ +PLH+A ++AH
Sbjct: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKG-ANVNEKNKDFMTPLHVAAERAHND 572
Query: 741 LVPLLVDAGCSVNAEDEEGDTALH-VALQRHQLLPLVADGAGGDPGPLQL 789
++ +L G +NA D G TALH AL H + G DP + L
Sbjct: 573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
Score = 87.8 bits (216), Expect = 5e-17
Identities = 85/318 (26%), Positives = 122/318 (38%), Gaps = 53/318 (16%)
Query: 518 DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLS 577
D + + T L AA +V ++ LL A V D G LH A E +L+
Sbjct: 679 DLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVR 738
Query: 578 AGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
G + + + T LH A +G E+ + L + G D + +TPL T
Sbjct: 739 HGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQ 798
Query: 638 GIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALH 697
++ +G L A+ KG V+K+ + T LH
Sbjct: 799 DLL----------------RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 842
Query: 698 LAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDE 757
LAA N+ EVA+ L+ G DVN +++ PLH A HV + LL+ VNA D+
Sbjct: 843 LAAGYNNLEVAEYLLEHG-ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK 901
Query: 758 EGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALE 817
T LH A Q+ G QL + L A
Sbjct: 902 WAFTPLHEAAQK---------------GRTQLCALLLA---------------------H 925
Query: 818 GADVSYTNHRGRSPLDLA 835
GAD + N G++PLDLA
Sbjct: 926 GADPTMKNQEGQTPLDLA 943
Score = 79.0 bits (193), Expect = 2e-14
Identities = 95/363 (26%), Positives = 150/363 (41%), Gaps = 49/363 (13%)
Query: 518 DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLS 577
D + + L AA G+ +++ LLQ A V DD G LH A E +LL
Sbjct: 211 DMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC 270
Query: 578 AGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH----SAISAG 633
G +A ++ T LH A +G ++V L + G D N+ + + L SA +
Sbjct: 271 QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVL 330
Query: 634 TG-----------ASG----IVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKIL 678
TG SG ++ +LT + N++ A++ + T LH A+ V+ +L
Sbjct: 331 TGEYKKDELLEAARSGNEEKLMALLTPL-NVNCHASDGRKSTPLHLAAGYNRVRIVQLLL 389
Query: 679 ARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH 738
V AK + G LH A H EV ++L++ G C VN + +PLH A +
Sbjct: 390 QHGAD-VHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNR 447
Query: 739 VGLVPLLVDAGCSVNAEDEEGDTALHVA------------LQRHQLLPLVADGAGGDPGP 786
V + LL+ G + G +A+ +A + H LL + D
Sbjct: 448 VEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAARE---ADLAK 504
Query: 787 LQLLSRLQASGL--PGSAELTVGAAVAC----------FLALEGADVSYTNHRGRSPLDL 834
++ L+ P S E + AVA L +GA+V+ N +PL +
Sbjct: 505 VKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHV 564
Query: 835 AAE 837
AAE
Sbjct: 565 AAE 567
Score = 75.1 bits (183), Expect = 3e-13
Identities = 101/366 (27%), Positives = 148/366 (40%), Gaps = 65/366 (17%)
Query: 488 PEHPGRLVVEV---ALGNAARALDLLRRRP----EQVDTKN--QGRTALQVAA---YLGQ 535
PE RL E +L AAR DL + + E ++ K TAL A + +
Sbjct: 478 PELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKR 537
Query: 536 VELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHV 595
++ LLL+ A V+ + + T LH AA + VL G + +A+++ TALH
Sbjct: 538 KQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHR 597
Query: 596 AVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATN 655
A G L+ R L G D ++ L +A G + ++L+E I T+
Sbjct: 598 AALAGHLQTCRLLLSYGSDPSI------ISLQGFTAAQMGNEAVQQILSESTPI---RTS 648
Query: 656 SQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDG--FTALHLAALNNHREVAQILIR 713
+ LL AS G V+++ + Q V+ + +G T LH AA N V + L+
Sbjct: 649 DVDYRLLE-ASKAGDLETVKQLCSS--QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
Query: 714 EGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLL 773
G DV+ +++ PLH A H + LLV G SVN D T LH A +
Sbjct: 706 HG-ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK---- 760
Query: 774 PLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALE-GADVSYTNHRGRSPL 832
G C L L+ GAD + N G +PL
Sbjct: 761 ---------------------------------GKYEICKLLLKHGADPTKKNRDGNTPL 787
Query: 833 DLAAEG 838
DL EG
Sbjct: 788 DLVKEG 793
Score = 65.9 bits (159), Expect = 2e-10
Identities = 75/293 (25%), Positives = 122/293 (41%), Gaps = 33/293 (11%)
Query: 566 GNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTP 625
G+ R++ +A A + +S+ LH A G +VV L + G +V+ D P
Sbjct: 193 GDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIP 252
Query: 626 LHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLV 685
LH+A S G V L D A ++ +T LH A++KG + V +L +
Sbjct: 253 LHNACSFGHAE---VVSLLLCQGADPNARDNWNYTPLHEAAIKG-KIDVCIVLLQHGADP 308
Query: 686 DAKKEDGFTALHL--------------------AALNNHREVAQILIREGRCDVNVRNRK 725
+ + DG +AL L AA + + E L+ + + + +
Sbjct: 309 NIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGR 368
Query: 726 LQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ--RHQLLP-LVADGAGG 782
+PLHLA V +V LL+ G V+A+D+ G LH A +++ L+ GA
Sbjct: 369 KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV 428
Query: 783 DPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLA 835
+ L + L + E V L GAD + N G+S +D+A
Sbjct: 429 NAMDLWQFTPLHEAASKNRVE------VCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 49.3 bits (116), Expect = 2e-05
Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 3/119 (2%)
Query: 514 PEQV---DTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPE 570
PE + DT+ + T L +AA +E+ LL+ A V+ D G LH AA +
Sbjct: 825 PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVD 884
Query: 571 ATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSA 629
+L+ +A + T LH A Q+G ++ L G D + + TPL A
Sbjct: 885 IAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 102 bits (254), Expect = 2e-21
Identities = 107/344 (31%), Positives = 150/344 (43%), Gaps = 40/344 (11%)
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L AA G V++++LLL +A V+ GNTAL YA G + +VLL +G +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAG--TGASGIVEV 642
N T L A G +EV R L E G +N HS+ SA++ G +V
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGIN---THSNEFKESALTLACYKGHLEMVRF 419
Query: 643 LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALN 702
L E D + T L A + GH R +L Q V+ + + L LAA
Sbjct: 420 LLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ-VNMPADSFESPLTLAACG 477
Query: 703 NHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE-GDT 761
H E+A +LI G + N + +PL A ++ H +V LL+ G ++NA+ EE +T
Sbjct: 478 GHVELAALLIERG-ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 762 ALHVALQRHQLLPLVAD---GAGGD--------------PGPLQLLSRLQASGLPGSAEL 804
AL +A L VAD AG D G L+L+ L A+G A
Sbjct: 537 ALTLACCGGFL--EVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 805 TVG------------AAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L GAD+ + + GR+PL AA
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Score = 87.8 bits (216), Expect = 5e-17
Identities = 88/303 (29%), Positives = 133/303 (43%), Gaps = 23/303 (7%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL +Q ++ TAL A G VE+ RLLL + A V++P D + L AA G
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
E +L+ G + +N T L A + G E+V L +G ++N A ++ +
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN---AQTEETQET 536
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQG-FTLLHHASLKGHALAVRKILARARQLVDA 687
A++ G +EV + I A G T L A+ +GH V+ +LA A V A
Sbjct: 537 ALTLAC-CGGFLEVADFL--IKAGADIELGCSTPLMEAAQEGHLELVKYLLA-AGANVHA 592
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
G TAL A N H +VA +L++ G D+ + ++PL A + HV V L+
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 748 AGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVG 807
G +VN D H +L L G G L ++ L A G + L G
Sbjct: 652 KGANVNRTTANND---------HTVLSLACAG-----GHLAVVELLLAHGADPTHRLKDG 697
Query: 808 AAV 810
+ +
Sbjct: 698 STM 700
Score = 87.4 bits (215), Expect = 6e-17
Identities = 111/370 (30%), Positives = 158/370 (42%), Gaps = 54/370 (14%)
Query: 455 PEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLV--VEVALGNAARALDLLRR 512
PE A L+ A LS A K A DPE RL V AL AA AL +R
Sbjct: 169 PETQARLEALLEAA-GIGKLSTADGKAFA---DPEVLRRLTSSVSCALDEAAAALTRMRA 224
Query: 513 RPEQVDTKNQGRT---ALQVAAYLGQVELIRLLLQARAGVDLPDDEGN------------ 557
T N G++ +L A G V +R LL V+ +EG
Sbjct: 225 E----STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
Query: 558 ----------------------TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHV 595
T L AA G + ++LL+ +A +ST +TAL
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 596 AVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATN 655
A G+++VV+ L E G + + + TPL A SA G + +L E T +N
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSA--GHVEVARLLLENGAGINTHSN 398
Query: 656 SQGFTLLHHASLKGHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE 714
+ L A KGH VR +L A A Q + K ++ TAL A ++ H EVA++L+
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQ--EHKTDEMHTALMEACMDGHVEVARLLLDS 456
Query: 715 GRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTAL-HVALQRHQLL 773
G VN+ +SPL LA HV L LL++ G S+ ++EG T L A + H+ +
Sbjct: 457 G-AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 774 PLVADGAGGD 783
+ G G +
Sbjct: 516 VALLLGQGAN 525
Score = 83.2 bits (204), Expect = 1e-15
Identities = 89/331 (26%), Positives = 139/331 (41%), Gaps = 43/331 (12%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T++ TAL +A G EL++ LL+ A ++ D +G T L AA +LL
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 579 GCRADAINS-TQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
G +A + T+ T L +A G EVV L RG + + TPL +++A G
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL--SLAASGGYV 1196
Query: 638 GIVEVLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
I+++L I+ + G + L A++ GH AV+ +L + + + TAL
Sbjct: 1197 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1256
Query: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAE- 755
LA EV +L+ + + +V R + +PL A + + +L+D G VNA
Sbjct: 1257 TLACFQGRTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1315
Query: 756 -DEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFL 814
DTAL +A D G + EL +G
Sbjct: 1316 VPSSRDTALTIA---------------ADKGHYKF------------CELLIG------- 1341
Query: 815 ALEGADVSYTNHRGRSPLDLAAEGRVLKALQ 845
GA + N +G +PL LAA G L +Q
Sbjct: 1342 --RGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1370
Score = 83.2 bits (204), Expect = 1e-15
Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 7/250 (2%)
Query: 501 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDE--GN 557
G ++LL R + +N T L +AA G V +I++LL A A ++ G
Sbjct: 1160 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1219
Query: 558 TALHYAALGNQPEATRVLLSAGCRADA-INSTQSTALHVAVQRGFLEVVRALCERGCDVN 616
+ L AA+ A ++LL G +A I + ++TAL +A +G EVV L +R +V
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 617 LPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRK 676
TPL A S G G V +L + +++ S T L A+ KGH
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRV-LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338
Query: 677 ILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQ 736
++ R +D + + G T L LAA H +V Q+L++ G DV+ + + +PL A ++
Sbjct: 1339 LIGRGAH-IDVRNKKGNTPLWLAANGGHLDVVQLLVQAG-ADVDAADNRKITPLMAAFRK 1396
Query: 737 AHVGLVPLLV 746
HV +V LV
Sbjct: 1397 GHVKVVRYLV 1406
Score = 81.6 bits (200), Expect = 3e-15
Identities = 76/320 (23%), Positives = 132/320 (41%), Gaps = 36/320 (11%)
Query: 485 KSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ 544
+++ H L + A G+ LL R +G T L +AA G V ++ +LL
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Query: 545 ARAGVDLPDDEG-NTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLE 603
A ++ + +T L A G + E +LL+ G + N + T L +A G++
Sbjct: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 1197
Query: 604 VVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 663
+++ L G ++N ++A G + V++L ++ + + T L
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1257
Query: 664 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------- 716
A +G V +L R V+ + + G T L AA + EV ++L+ +G
Sbjct: 1258 LACFQGRTEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1316
Query: 717 -------------------CD--------VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 749
C+ ++VRN+K +PL LA H+ +V LLV AG
Sbjct: 1317 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1376
Query: 750 CSVNAEDEEGDTALHVALQR 769
V+A D T L A ++
Sbjct: 1377 ADVDAADNRKITPLMAAFRK 1396
Score = 53.9 bits (128), Expect = 7e-07
Identities = 60/225 (26%), Positives = 106/225 (47%), Gaps = 17/225 (7%)
Query: 474 LSVALDKLRAQKSDPEHPGRL----VVEVALGNAARALDLLRRRPEQVDTK---NQGRTA 526
+S+ LD+ K++ EH + ++E A G A +L + V+ + TA
Sbjct: 1268 VSLLLDR----KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
Query: 527 LQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAIN 586
L +AA G + LL+ A +D+ + +GNT L AA G + ++L+ AG DA +
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
Query: 587 STQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV 646
+ + T L A ++G ++VVR L + +VN SD+ I+ T + + +
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLVK---EVN--QFPSDSECMRYIATITDKEMLKKCHLCM 1438
Query: 647 PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
+I V A + Q +AS+ L + K+ +R+L A K +
Sbjct: 1439 ESI-VQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKRE 1482
Score = 50.4 bits (119), Expect = 8e-06
Identities = 32/84 (38%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Query: 685 VDAKKEDGF-TALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVP 743
+DA+ E TAL LA H E+ Q L+ G + R++K +PL LA HVG+V
Sbjct: 1075 IDAQTESNHDTALTLACAGGHEELVQTLLERG-ASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 744 LLVDAGCSVNAEDEE-GDTALHVA 766
+L+D G + A+ E DT L +A
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLA 1157
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 102 bits (254), Expect = 2e-21
Identities = 107/344 (31%), Positives = 150/344 (43%), Gaps = 40/344 (11%)
Query: 525 TALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADA 584
T L AA G V++++LLL +A V+ GNTAL YA G + +VLL +G +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 585 INSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAG--TGASGIVEV 642
N T L A G +EV R L E G +N HS+ SA++ G +V
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGIN---THSNEFKESALTLACYKGHLEMVRF 419
Query: 643 LTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALN 702
L E D + T L A + GH R +L Q V+ + + L LAA
Sbjct: 420 LLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ-VNMPADSFESPLTLAACG 477
Query: 703 NHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEE-GDT 761
H E+A +LI G + N + +PL A ++ H +V LL+ G ++NA+ EE +T
Sbjct: 478 GHVELAALLIERG-ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 762 ALHVALQRHQLLPLVAD---GAGGD--------------PGPLQLLSRLQASGLPGSAEL 804
AL +A L VAD AG D G L+L+ L A+G A
Sbjct: 537 ALTLACCGGFL--EVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATT 594
Query: 805 TVG------------AAVACFLALEGADVSYTNHRGRSPLDLAA 836
G VA L GAD+ + + GR+PL AA
Sbjct: 595 ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Score = 87.8 bits (216), Expect = 5e-17
Identities = 88/303 (29%), Positives = 133/303 (43%), Gaps = 23/303 (7%)
Query: 509 LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQ 568
LL +Q ++ TAL A G VE+ RLLL + A V++P D + L AA G
Sbjct: 420 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 479
Query: 569 PEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHS 628
E +L+ G + +N T L A + G E+V L +G ++N A ++ +
Sbjct: 480 VELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN---AQTEETQET 536
Query: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQG-FTLLHHASLKGHALAVRKILARARQLVDA 687
A++ G +EV + I A G T L A+ +GH V+ +LA A V A
Sbjct: 537 ALTLAC-CGGFLEVADFL--IKAGADIELGCSTPLMEAAQEGHLELVKYLLA-AGANVHA 592
Query: 688 KKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVD 747
G TAL A N H +VA +L++ G D+ + ++PL A + HV V L+
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAG-ADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 748 AGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVG 807
G +VN D H +L L G G L ++ L A G + L G
Sbjct: 652 KGANVNRTTANND---------HTVLSLACAG-----GHLAVVELLLAHGADPTHRLKDG 697
Query: 808 AAV 810
+ +
Sbjct: 698 STM 700
Score = 87.4 bits (215), Expect = 6e-17
Identities = 111/370 (30%), Positives = 158/370 (42%), Gaps = 54/370 (14%)
Query: 455 PEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLV--VEVALGNAARALDLLRR 512
PE A L+ A LS A K A DPE RL V AL AA AL +R
Sbjct: 169 PETQARLEALLEAA-GIGKLSTADGKAFA---DPEVLRRLTSSVSCALDEAAAALTRMRA 224
Query: 513 RPEQVDTKNQGRT---ALQVAAYLGQVELIRLLLQARAGVDLPDDEGN------------ 557
T N G++ +L A G V +R LL V+ +EG
Sbjct: 225 E----STANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
Query: 558 ----------------------TALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHV 595
T L AA G + ++LL+ +A +ST +TAL
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 596 AVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATN 655
A G+++VV+ L E G + + + TPL A SA G + +L E T +N
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSA--GHVEVARLLLENGAGINTHSN 398
Query: 656 SQGFTLLHHASLKGHALAVRKIL-ARARQLVDAKKEDGFTALHLAALNNHREVAQILIRE 714
+ L A KGH VR +L A A Q + K ++ TAL A ++ H EVA++L+
Sbjct: 399 EFKESALTLACYKGHLEMVRFLLEAGADQ--EHKTDEMHTALMEACMDGHVEVARLLLDS 456
Query: 715 GRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTAL-HVALQRHQLL 773
G VN+ +SPL LA HV L LL++ G S+ ++EG T L A + H+ +
Sbjct: 457 G-AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Query: 774 PLVADGAGGD 783
+ G G +
Sbjct: 516 VALLLGQGAN 525
Score = 83.2 bits (204), Expect = 1e-15
Identities = 89/331 (26%), Positives = 139/331 (41%), Gaps = 43/331 (12%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T++ TAL +A G EL++ LL+ A ++ D +G T L AA +LL
Sbjct: 828 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887
Query: 579 GCRADAINS-TQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
G +A + T+ T L +A G EVV L RG + + TPL +++A G
Sbjct: 888 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPL--SLAASGGYV 945
Query: 638 GIVEVLTEV-PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
I+++L I+ + G + L A++ GH AV+ +L + + + TAL
Sbjct: 946 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1005
Query: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
LA EV +L+ + + +V R + +PL A + + +L+D G VNA
Sbjct: 1006 TLACFQGRTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1064
Query: 757 --EEGDTALHVALQRHQLLPLVADGAGGDPGPLQLLSRLQASGLPGSAELTVGAAVACFL 814
DTAL +A D G + EL +G
Sbjct: 1065 VPSSRDTALTIA---------------ADKGHYKF------------CELLIG------- 1090
Query: 815 ALEGADVSYTNHRGRSPLDLAAEGRVLKALQ 845
GA + N +G +PL LAA G L +Q
Sbjct: 1091 --RGAHIDVRNKKGNTPLWLAANGGHLDVVQ 1119
Score = 83.2 bits (204), Expect = 1e-15
Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 7/250 (2%)
Query: 501 GNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLGQVELIRLLLQARAGVDLPDDE--GN 557
G ++LL R + +N T L +AA G V +I++LL A A ++ G
Sbjct: 909 GGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 968
Query: 558 TALHYAALGNQPEATRVLLSAGCRADA-INSTQSTALHVAVQRGFLEVVRALCERGCDVN 616
+ L AA+ A ++LL G +A I + ++TAL +A +G EVV L +R +V
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 617 LPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRK 676
TPL A S G G V +L + +++ S T L A+ KGH
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRV-LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087
Query: 677 ILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQ 736
++ R +D + + G T L LAA H +V Q+L++ G DV+ + + +PL A ++
Sbjct: 1088 LIGRGAH-IDVRNKKGNTPLWLAANGGHLDVVQLLVQAG-ADVDAADNRKITPLMAAFRK 1145
Query: 737 AHVGLVPLLV 746
HV +V LV
Sbjct: 1146 GHVKVVRYLV 1155
Score = 81.6 bits (200), Expect = 3e-15
Identities = 76/320 (23%), Positives = 132/320 (41%), Gaps = 36/320 (11%)
Query: 485 KSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQ 544
+++ H L + A G+ LL R +G T L +AA G V ++ +LL
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 545 ARAGVDLPDDEG-NTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLE 603
A ++ + +T L A G + E +LL+ G + N + T L +A G++
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946
Query: 604 VVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLH 663
+++ L G ++N ++A G + V++L ++ + + T L
Sbjct: 947 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1006
Query: 664 HASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGR------- 716
A +G V +L R V+ + + G T L AA + EV ++L+ +G
Sbjct: 1007 LACFQGRTEVVSLLLDRKAN-VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065
Query: 717 -------------------CD--------VNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 749
C+ ++VRN+K +PL LA H+ +V LLV AG
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125
Query: 750 CSVNAEDEEGDTALHVALQR 769
V+A D T L A ++
Sbjct: 1126 ADVDAADNRKITPLMAAFRK 1145
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/257 (26%), Positives = 103/257 (40%), Gaps = 19/257 (7%)
Query: 519 TKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSA 578
T N T L +A G + ++ LLL A +G+T L AA G LL
Sbjct: 660 TANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Query: 579 G---CRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISA--- 632
A + TQ T + R V+AL + +P D P + +
Sbjct: 720 PNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL-----PMVVPPQEPDKPPANVATTLPI 774
Query: 633 -GTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
SG ++ P + A+ SQ T + A+ + +DA+ E
Sbjct: 775 RNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAM----LPIYPAIDIDAQTES 830
Query: 692 GF-TALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC 750
TAL LA H E+ Q L+ G + R++K +PL LA HVG+V +L+D G
Sbjct: 831 NHDTALTLACAGGHEELVQTLLERG-ASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 751 SVNAEDEE-GDTALHVA 766
+ A+ E DT L +A
Sbjct: 890 DIEAQSERTKDTPLSLA 906
Score = 53.9 bits (128), Expect = 7e-07
Identities = 60/225 (26%), Positives = 106/225 (47%), Gaps = 17/225 (7%)
Query: 474 LSVALDKLRAQKSDPEHPGRL----VVEVALGNAARALDLLRRRPEQVDTK---NQGRTA 526
+S+ LD+ K++ EH + ++E A G A +L + V+ + TA
Sbjct: 1017 VSLLLDR----KANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
Query: 527 LQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAIN 586
L +AA G + LL+ A +D+ + +GNT L AA G + ++L+ AG DA +
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
Query: 587 STQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV 646
+ + T L A ++G ++VVR L + +VN SD+ I+ T + + +
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLVK---EVN--QFPSDSECMRYIATITDKEMLKKCHLCM 1187
Query: 647 PNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
+I V A + Q +AS+ L + K+ +R+L A K +
Sbjct: 1188 ESI-VQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKRE 1231
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 101 bits (251), Expect = 4e-21
Identities = 76/250 (30%), Positives = 126/250 (50%), Gaps = 13/250 (5%)
Query: 480 KLRAQKSDP----EHPGRLVVEVALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLG 534
K + +KSD ++ RL+ V G+A + LL ++ + +G+TA +AA G
Sbjct: 5 KAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKG 64
Query: 535 QVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALH 594
VE +R+++ V D G++ALH AA + E R LL + C A++++S+ TALH
Sbjct: 65 HVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
Query: 595 VAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTAT 654
A +G L+ V+ LCE +NL D + PL A+ G S I L + DV +
Sbjct: 125 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ--NGHSEICHFLLD-HGADVNSR 181
Query: 655 NSQGFTLLHHASLKGHALAVRKILARAR--QLVDAKKEDGFTALHLAALNNHREVAQILI 712
N G T L A G + AV ++ + LVD+ G+ ALH + L+ + + +L+
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL---GYNALHYSKLSENAGIQSLLL 238
Query: 713 REGRCDVNVR 722
+ D +++
Sbjct: 239 SKISQDADLK 248
Score = 80.1 bits (196), Expect = 1e-14
Identities = 71/253 (28%), Positives = 100/253 (39%), Gaps = 39/253 (15%)
Query: 513 RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQAR-AGVDLPDDEGNTALHYAALGNQPEA 571
R + N+ L A G E + LL + A D EG TA H AA E
Sbjct: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
Query: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAIS 631
RV+++ G A ++T +ALH+A + E +R L + C D
Sbjct: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD------------ 116
Query: 632 AGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
S G T LH+A+ +G AV+ IL + ++ K D
Sbjct: 117 ------------------------SSGKTALHYAAAQGCLQAVQ-ILCEHKSPINLKDLD 151
Query: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
G L LA N H E+ L+ G DVN RN+ ++ L LA + V L+ G
Sbjct: 152 GNIPLLLAVQNGHSEICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Query: 752 VNAEDEEGDTALH 764
+N D G ALH
Sbjct: 211 LNLVDSLGYNALH 223
Score = 73.6 bits (179), Expect = 9e-13
Identities = 57/176 (32%), Positives = 88/176 (50%), Gaps = 10/176 (5%)
Query: 596 AVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV--PNIDVT 652
AV+ G E V +L ++G D+ T H A A G VE L + +DVT
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA-----AAKGHVECLRVMITHGVDVT 80
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
A ++ G + LH A+ H +RK+L +++ ++ G TALH AA + QIL
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
E + +N+++ PL LAVQ H + L+D G VN+ ++ G TAL +A +
Sbjct: 140 -EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 22/178 (12%)
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
G A V +L + +G TA HLAA H E +++I G DV ++ S
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG-VDVTAQDTTGHS 88
Query: 729 PLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQ 788
LHLA + +H + L+ + C + D G TALH A A G +Q
Sbjct: 89 ALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA------------AAQGCLQAVQ 136
Query: 789 LL----SRLQASGLPGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
+L S + L G+ L + + + FL GADV+ N GR+ L LA E
Sbjct: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 101 bits (251), Expect = 4e-21
Identities = 76/250 (30%), Positives = 126/250 (50%), Gaps = 13/250 (5%)
Query: 480 KLRAQKSDP----EHPGRLVVEVALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLG 534
K + +KSD ++ RL+ V G+A + LL ++ + +G+TA +AA G
Sbjct: 5 KAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKG 64
Query: 535 QVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALH 594
VE +R+++ V D G++ALH AA + E R LL + C A++++S+ TALH
Sbjct: 65 HVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
Query: 595 VAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTAT 654
A +G L+ V+ LCE +NL D + PL A+ G S I L + DV +
Sbjct: 125 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ--NGHSEICHFLLD-HGADVNSR 181
Query: 655 NSQGFTLLHHASLKGHALAVRKILARAR--QLVDAKKEDGFTALHLAALNNHREVAQILI 712
N G T L A G + AV ++ + LVD+ G+ ALH + L+ + + +L+
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL---GYNALHYSKLSENAGIQSLLL 238
Query: 713 REGRCDVNVR 722
+ D +++
Sbjct: 239 SKISQDADLK 248
Score = 80.1 bits (196), Expect = 1e-14
Identities = 71/253 (28%), Positives = 100/253 (39%), Gaps = 39/253 (15%)
Query: 513 RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQAR-AGVDLPDDEGNTALHYAALGNQPEA 571
R + N+ L A G E + LL + A D EG TA H AA E
Sbjct: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
Query: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAIS 631
RV+++ G A ++T +ALH+A + E +R L + C D
Sbjct: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD------------ 116
Query: 632 AGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
S G T LH+A+ +G AV+ IL + ++ K D
Sbjct: 117 ------------------------SSGKTALHYAAAQGCLQAVQ-ILCEHKSPINLKDLD 151
Query: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
G L LA N H E+ L+ G DVN RN+ ++ L LA + V L+ G
Sbjct: 152 GNIPLLLAVQNGHSEICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Query: 752 VNAEDEEGDTALH 764
+N D G ALH
Sbjct: 211 LNLVDSLGYNALH 223
Score = 73.6 bits (179), Expect = 9e-13
Identities = 57/176 (32%), Positives = 88/176 (50%), Gaps = 10/176 (5%)
Query: 596 AVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV--PNIDVT 652
AV+ G E V +L ++G D+ T H A A G VE L + +DVT
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA-----AAKGHVECLRVMITHGVDVT 80
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
A ++ G + LH A+ H +RK+L +++ ++ G TALH AA + QIL
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
E + +N+++ PL LAVQ H + L+D G VN+ ++ G TAL +A +
Sbjct: 140 -EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 22/178 (12%)
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
G A V +L + +G TA HLAA H E +++I G DV ++ S
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG-VDVTAQDTTGHS 88
Query: 729 PLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQ 788
LHLA + +H + L+ + C + D G TALH A A G +Q
Sbjct: 89 ALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA------------AAQGCLQAVQ 136
Query: 789 LL----SRLQASGLPGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
+L S + L G+ L + + + FL GADV+ N GR+ L LA E
Sbjct: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 101 bits (251), Expect = 4e-21
Identities = 76/250 (30%), Positives = 126/250 (50%), Gaps = 13/250 (5%)
Query: 480 KLRAQKSDP----EHPGRLVVEVALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLG 534
K + +KSD ++ RL+ V G+A + LL ++ + +G+TA +AA G
Sbjct: 5 KAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKG 64
Query: 535 QVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALH 594
VE +R+++ V D G++ALH AA + E R LL + C A++++S+ TALH
Sbjct: 65 HVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
Query: 595 VAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTAT 654
A +G L+ V+ LCE +NL D + PL A+ G S I L + DV +
Sbjct: 125 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ--NGHSEICHFLLD-HGADVNSR 181
Query: 655 NSQGFTLLHHASLKGHALAVRKILARAR--QLVDAKKEDGFTALHLAALNNHREVAQILI 712
N G T L A G + AV ++ + LVD+ G+ ALH + L+ + + +L+
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL---GYNALHYSKLSENAGIQSLLL 238
Query: 713 REGRCDVNVR 722
+ D +++
Sbjct: 239 SKISQDADLK 248
Score = 80.1 bits (196), Expect = 1e-14
Identities = 71/253 (28%), Positives = 100/253 (39%), Gaps = 39/253 (15%)
Query: 513 RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQAR-AGVDLPDDEGNTALHYAALGNQPEA 571
R + N+ L A G E + LL + A D EG TA H AA E
Sbjct: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
Query: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAIS 631
RV+++ G A ++T +ALH+A + E +R L + C D
Sbjct: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD------------ 116
Query: 632 AGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
S G T LH+A+ +G AV+ IL + ++ K D
Sbjct: 117 ------------------------SSGKTALHYAAAQGCLQAVQ-ILCEHKSPINLKDLD 151
Query: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
G L LA N H E+ L+ G DVN RN+ ++ L LA + V L+ G
Sbjct: 152 GNIPLLLAVQNGHSEICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Query: 752 VNAEDEEGDTALH 764
+N D G ALH
Sbjct: 211 LNLVDSLGYNALH 223
Score = 73.6 bits (179), Expect = 9e-13
Identities = 57/176 (32%), Positives = 88/176 (50%), Gaps = 10/176 (5%)
Query: 596 AVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV--PNIDVT 652
AV+ G E V +L ++G D+ T H A A G VE L + +DVT
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA-----AAKGHVECLRVMITHGVDVT 80
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
A ++ G + LH A+ H +RK+L +++ ++ G TALH AA + QIL
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
E + +N+++ PL LAVQ H + L+D G VN+ ++ G TAL +A +
Sbjct: 140 -EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 22/178 (12%)
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
G A V +L + +G TA HLAA H E +++I G DV ++ S
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG-VDVTAQDTTGHS 88
Query: 729 PLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQ 788
LHLA + +H + L+ + C + D G TALH A A G +Q
Sbjct: 89 ALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA------------AAQGCLQAVQ 136
Query: 789 LL----SRLQASGLPGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
+L S + L G+ L + + + FL GADV+ N GR+ L LA E
Sbjct: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 101 bits (251), Expect = 4e-21
Identities = 76/250 (30%), Positives = 126/250 (50%), Gaps = 13/250 (5%)
Query: 480 KLRAQKSDP----EHPGRLVVEVALGNAARALDLLRRRPEQVDTKN-QGRTALQVAAYLG 534
K + +KSD ++ RL+ V G+A + LL ++ + +G+TA +AA G
Sbjct: 5 KAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKG 64
Query: 535 QVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALH 594
VE +R+++ V D G++ALH AA + E R LL + C A++++S+ TALH
Sbjct: 65 HVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
Query: 595 VAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTAT 654
A +G L+ V+ LCE +NL D + PL A+ G S I L + DV +
Sbjct: 125 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQ--NGHSEICHFLLD-HGADVNSR 181
Query: 655 NSQGFTLLHHASLKGHALAVRKILARAR--QLVDAKKEDGFTALHLAALNNHREVAQILI 712
N G T L A G + AV ++ + LVD+ G+ ALH + L+ + + +L+
Sbjct: 182 NKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL---GYNALHYSKLSENAGIQSLLL 238
Query: 713 REGRCDVNVR 722
+ D +++
Sbjct: 239 SKISQDADLK 248
Score = 80.1 bits (196), Expect = 1e-14
Identities = 71/253 (28%), Positives = 100/253 (39%), Gaps = 39/253 (15%)
Query: 513 RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQAR-AGVDLPDDEGNTALHYAALGNQPEA 571
R + N+ L A G E + LL + A D EG TA H AA E
Sbjct: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
Query: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAIS 631
RV+++ G A ++T +ALH+A + E +R L + C D
Sbjct: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD------------ 116
Query: 632 AGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKED 691
S G T LH+A+ +G AV+ IL + ++ K D
Sbjct: 117 ------------------------SSGKTALHYAAAQGCLQAVQ-ILCEHKSPINLKDLD 151
Query: 692 GFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCS 751
G L LA N H E+ L+ G DVN RN+ ++ L LA + V L+ G
Sbjct: 152 GNIPLLLAVQNGHSEICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGAD 210
Query: 752 VNAEDEEGDTALH 764
+N D G ALH
Sbjct: 211 LNLVDSLGYNALH 223
Score = 73.6 bits (179), Expect = 9e-13
Identities = 57/176 (32%), Positives = 88/176 (50%), Gaps = 10/176 (5%)
Query: 596 AVQRGFLEVVRALC-ERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEV--PNIDVT 652
AV+ G E V +L ++G D+ T H A A G VE L + +DVT
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA-----AAKGHVECLRVMITHGVDVT 80
Query: 653 ATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILI 712
A ++ G + LH A+ H +RK+L +++ ++ G TALH AA + QIL
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLL-QSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
Query: 713 REGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQ 768
E + +N+++ PL LAVQ H + L+D G VN+ ++ G TAL +A +
Sbjct: 140 -EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 22/178 (12%)
Query: 669 GHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQS 728
G A V +L + +G TA HLAA H E +++I G DV ++ S
Sbjct: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG-VDVTAQDTTGHS 88
Query: 729 PLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGPLQ 788
LHLA + +H + L+ + C + D G TALH A A G +Q
Sbjct: 89 ALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYA------------AAQGCLQAVQ 136
Query: 789 LL----SRLQASGLPGSAELTVG-----AAVACFLALEGADVSYTNHRGRSPLDLAAE 837
+L S + L G+ L + + + FL GADV+ N GR+ L LA E
Sbjct: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,654,756
Number of Sequences: 37866
Number of extensions: 2128055
Number of successful extensions: 12797
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 196
Number of HSP's that attempted gapping in prelim test: 7382
Number of HSP's gapped (non-prelim): 2419
length of query: 1013
length of database: 18,247,518
effective HSP length: 112
effective length of query: 901
effective length of database: 14,006,526
effective search space: 12619879926
effective search space used: 12619879926
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.