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Search of human proteins with 212276078
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|212276078 leucine rich repeat (in FLII) interacting protein
1 isoform 1 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 1235 0.0
gi|5453726 leucine rich repeat (in FLII) interacting protein 2 i... 566 e-161
gi|212276088 leucine rich repeat (in FLII) interacting protein 1... 455 e-128
gi|212276096 leucine rich repeat (in FLII) interacting protein 1... 332 6e-91
gi|197276647 leucine rich repeat (in FLII) interacting protein 2... 295 9e-80
gi|212276070 leucine rich repeat (in FLII) interacting protein 1... 271 1e-72
gi|212276104 leucine rich repeat (in FLII) interacting protein 1... 268 9e-72
gi|8923224 leucine rich repeat (in FLII) interacting protein 2 i... 239 4e-63
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 86 1e-16
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 78 2e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 78 2e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 78 3e-14
gi|71061468 centromere protein E [Homo sapiens] 77 5e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 76 1e-13
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 75 1e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 74 3e-13
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 74 4e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 4e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 4e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 4e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 4e-13
gi|38044112 restin isoform b [Homo sapiens] 73 9e-13
gi|4506751 restin isoform a [Homo sapiens] 73 9e-13
gi|31982906 cingulin-like 1 [Homo sapiens] 73 9e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 72 1e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 1e-12
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 72 1e-12
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 72 2e-12
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 71 3e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 71 3e-12
>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
isoform 1 [Homo sapiens]
Length = 640
Score = 1235 bits (3196), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MDMGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQK 60
MDMGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQK
Sbjct: 1 MDMGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQK 60
Query: 61 EIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDL 120
EIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDL
Sbjct: 61 EIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDL 120
Query: 121 EYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST 180
EYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST
Sbjct: 121 EYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGST 180
Query: 181 SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLG 240
SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLG
Sbjct: 181 SGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLG 240
Query: 241 GTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK 300
GTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK
Sbjct: 241 GTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK 300
Query: 301 KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF 360
KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF
Sbjct: 301 KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF 360
Query: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSV 420
QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSV
Sbjct: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSV 420
Query: 421 RSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS 480
RSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS
Sbjct: 421 RSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS 480
Query: 481 TGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD 540
TGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD
Sbjct: 481 TGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMD 540
Query: 541 LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK 600
LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK
Sbjct: 541 LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK 600
Query: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ
Sbjct: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
>gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
Length = 721
Score = 567 bits (1460), Expect = e-161
Identities = 343/730 (46%), Positives = 453/730 (62%), Gaps = 101/730 (13%)
Query: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
Query: 63 YQVQKKYYGLDTKWGDIEQWMEDSER--YSRRSRRNTSASDEDERMSVGSRGSLR----- 115
+ D KWG I++W+EDSER YS RS + ++ +S+ S GS R
Sbjct: 61 -----SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFK 115
Query: 116 -------------------------SQPDLEYGGPYAWTNGYDG-------ELYGSQSLN 143
S DL G Y Y Y ++ +
Sbjct: 116 DRSSRLSSLNHSYSHSHGMKKRSSDSHKDL-LSGLYFDQRNYSSLRHSKPTSAYYTRQSS 174
Query: 144 RRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRG---STSGSRAPSE---YSGHLNSSS 197
P Y + R S + + +L S G + G R PSE YS ++S+
Sbjct: 175 SLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSAR 234
Query: 198 RA-------------SSRASSARASPVV------------------------------EE 214
+ S RAS R VV +E
Sbjct: 235 SSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDE 294
Query: 215 RPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQI 274
+ +K + E +R SA+ L G SSRRGSGDTS ID + S+ E++++ +LKDQI
Sbjct: 295 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQI 354
Query: 275 QDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQL 334
QDVEG+YMQGLKE+K+SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+
Sbjct: 355 QDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQM 414
Query: 335 AESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREIS 394
AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E++EE +++QQK + +E+
Sbjct: 415 AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVF 474
Query: 395 DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELK---KHGIILNSEIAT 451
DLQET+ WKDKKIGALE+QKE+ +R+ERD LREE+ L+E +K KHG+++ +
Sbjct: 475 DLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTP 534
Query: 452 NGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQL 511
NG+ S + T +++E L+S G+G LD+RL+KL E+E LL QI+KLK QL
Sbjct: 535 NGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQL 591
Query: 512 -EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNV 570
EERQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT LEQ++
Sbjct: 592 EEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSI 651
Query: 571 IRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK 630
RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL KRLEKMK
Sbjct: 652 SRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
Query: 631 ANRSALLSQQ 640
ANR+ALL+QQ
Sbjct: 712 ANRTALLAQQ 721
>gi|212276088 leucine rich repeat (in FLII) interacting protein 1
isoform 2 [Homo sapiens]
Length = 394
Score = 455 bits (1170), Expect = e-128
Identities = 274/434 (63%), Positives = 303/434 (69%), Gaps = 86/434 (19%)
Query: 207 RASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKE 266
R VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSG DT SI
Sbjct: 47 RQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSG------DTSISI----- 95
Query: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 326
D E ++E+KDSLA
Sbjct: 96 ---------DTEAS----IREIKDSLA--------------------------------- 109
Query: 327 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQ 386
E+EE+ ++ N + + EK + +Q +K+ L + EE L E R+ ++
Sbjct: 110 --EVEEKYKKAM----VSNAQLDNEK---TNFMYQVDTLKDMLLELEEQLAESRRQYEE- 159
Query: 387 ASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILN 446
K+K+ ER+K ++ + +++E + +E L+KHGIILN
Sbjct: 160 ----------------KNKEF---EREKHAHSILQFQFAEVKEALKQREEMLEKHGIILN 200
Query: 447 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 506
SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK
Sbjct: 201 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 260
Query: 507 LKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL 566
LKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL
Sbjct: 261 LKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL 320
Query: 567 EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRL 626
EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRL
Sbjct: 321 EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRL 380
Query: 627 EKMKANRSALLSQQ 640
EKMKANRSALLSQQ
Sbjct: 381 EKMKANRSALLSQQ 394
Score = 59.3 bits (142), Expect = 1e-08
Identities = 34/48 (70%), Positives = 40/48 (83%), Gaps = 1/48 (2%)
Query: 22 EDDALNQIARE-AEARLAAKRAARAEAREIRMKELERQQKEIYQVQKK 68
E D L+ A++ AEARLAAKRAARAEAREIRMKELERQQKE+ + +K
Sbjct: 11 EIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEK 58
>gi|212276096 leucine rich repeat (in FLII) interacting protein 1
isoform 3 [Homo sapiens]
Length = 808
Score = 332 bits (851), Expect = 6e-91
Identities = 195/293 (66%), Positives = 217/293 (74%), Gaps = 13/293 (4%)
Query: 176 RRGSTSGSRAPSEYSGHLNSSSRASSRAS-SARASPVVEERPEKDFTEKGSRNMPGLSAA 234
R+ S S S S+S R S +R S VEERPEKDFTEKGSRNMPGLSAA
Sbjct: 47 RQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAA 106
Query: 235 TLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE 294
TLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE
Sbjct: 107 TLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE 166
Query: 295 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 354
VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA
Sbjct: 167 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 226
Query: 355 HSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQK 414
HSILQFQFAEVKEALKQREEMLE+ + + ++ E SD + ++ G + K
Sbjct: 227 HSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQ----GPTKMTK 282
Query: 415 EFFDSVRSERDDL--REEVVMLKEEL----KKHGIILNSEIATNGETSDTLNN 461
E ++++S D R V +K E+ K I+ N+E T DT+ +
Sbjct: 283 EELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTE--KEQHTEDTVKD 333
Score = 105 bits (261), Expect = 2e-22
Identities = 65/95 (68%), Positives = 68/95 (71%), Gaps = 23/95 (24%)
Query: 22 EDDALNQIARE-AEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIE 80
E D L+ A++ AEARLAAKRAARAEAREIRMKELERQQKE
Sbjct: 11 EIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE------------------- 51
Query: 81 QWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLR 115
EDSERYSRRSRRNTSASDEDERMSVGSRGSLR
Sbjct: 52 ---EDSERYSRRSRRNTSASDEDERMSVGSRGSLR 83
Score = 34.3 bits (77), Expect = 0.36
Identities = 33/154 (21%), Positives = 63/154 (40%), Gaps = 4/154 (2%)
Query: 199 ASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE 258
A + A ++ V + E++ E G R+ + S GT ++DT+
Sbjct: 482 AEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQ 541
Query: 259 ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMY 318
++KE +E K D +G+ + + K + + K KK+ V L + K Y
Sbjct: 542 NEPLDMKEPDEEK---SDQQGEALDS-SQKKTKNKKKKNKKKKSPVPVETLKDVKKELTY 597
Query: 319 QVDTLKDMLLELEEQLAESRRQYEEKNKEFEREK 352
Q L ++ E + + + + E +N+ E K
Sbjct: 598 QNTDLSEIKEEEQVKSTDRKSAVEAQNEVTENPK 631
>gi|197276647 leucine rich repeat (in FLII) interacting protein 2
isoform 3 [Homo sapiens]
Length = 424
Score = 295 bits (755), Expect = 9e-80
Identities = 179/435 (41%), Positives = 261/435 (60%), Gaps = 66/435 (15%)
Query: 207 RASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKE 266
R ++E+ +K + E +R SA+ L G SSRRGSGDTS ID + S+ E+++
Sbjct: 55 RQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRD 114
Query: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 326
+ +LKDQIQDVEG+YMQGLKE LK+
Sbjct: 115 IYDLKDQIQDVEGRYMQGLKE-----------------------------------LKES 139
Query: 327 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQ 386
L E+EE+ ++ N + + EK+ L +Q +K+ ++++EE + E + +++
Sbjct: 140 LSEVEEKYKKAM----VSNAQLDNEKNN---LIYQVDTLKDVIEEQEEQMAEFYRENEEK 192
Query: 387 ASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILN 446
+ LERQK ++ + ++L+E + E ++KHG+++
Sbjct: 193 SKE--------------------LERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVII 232
Query: 447 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 506
+ NG+ S + T +++E L+S G+G LD+RL+KL E+E LL QI+K
Sbjct: 233 PDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 289
Query: 507 LKGQLEE-RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITA 565
LK QLEE RQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT
Sbjct: 290 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 349
Query: 566 LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL KR
Sbjct: 350 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR 409
Query: 626 LEKMKANRSALLSQQ 640
LEKMKANR+ALL+QQ
Sbjct: 410 LEKMKANRTALLAQQ 424
Score = 99.4 bits (246), Expect = 9e-21
Identities = 57/111 (51%), Positives = 73/111 (65%), Gaps = 15/111 (13%)
Query: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE+
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 63 YQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGS 113
+ K Y +E Y+R S RN++++ + RGS
Sbjct: 61 DEKSDKQY---------------AENYTRPSSRNSASATTPLSGNSSRRGS 96
>gi|212276070 leucine rich repeat (in FLII) interacting protein 1
isoform 4 [Homo sapiens]
Length = 784
Score = 271 bits (694), Expect = 1e-72
Identities = 171/293 (58%), Positives = 193/293 (65%), Gaps = 37/293 (12%)
Query: 176 RRGSTSGSRAPSEYSGHLNSSSRASSRAS-SARASPVVEERPEKDFTEKGSRNMPGLSAA 234
R+ S S S S+S R S +R S VEERPEKDFTEKGSRNMPGLSAA
Sbjct: 47 RQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAA 106
Query: 235 TLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE 294
TLASLGGTSSRRGSGDTSISIDTEASIREIK DSLAE
Sbjct: 107 TLASLGGTSSRRGSGDTSISIDTEASIREIK------------------------DSLAE 142
Query: 295 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 354
VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA
Sbjct: 143 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 202
Query: 355 HSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQK 414
HSILQFQFAEVKEALKQREEMLE+ + + ++ E SD + ++ G + K
Sbjct: 203 HSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQ----GPTKMTK 258
Query: 415 EFFDSVRSERDDL--REEVVMLKEEL----KKHGIILNSEIATNGETSDTLNN 461
E ++++S D R V +K E+ K I+ N+E T DT+ +
Sbjct: 259 EELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTE--KEQHTEDTVKD 309
Score = 105 bits (261), Expect = 2e-22
Identities = 65/95 (68%), Positives = 68/95 (71%), Gaps = 23/95 (24%)
Query: 22 EDDALNQIARE-AEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIE 80
E D L+ A++ AEARLAAKRAARAEAREIRMKELERQQKE
Sbjct: 11 EIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE------------------- 51
Query: 81 QWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLR 115
EDSERYSRRSRRNTSASDEDERMSVGSRGSLR
Sbjct: 52 ---EDSERYSRRSRRNTSASDEDERMSVGSRGSLR 83
Score = 34.3 bits (77), Expect = 0.36
Identities = 33/154 (21%), Positives = 63/154 (40%), Gaps = 4/154 (2%)
Query: 199 ASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE 258
A + A ++ V + E++ E G R+ + S GT ++DT+
Sbjct: 458 AEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQ 517
Query: 259 ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMY 318
++KE +E K D +G+ + + K + + K KK+ V L + K Y
Sbjct: 518 NEPLDMKEPDEEK---SDQQGEALDS-SQKKTKNKKKKNKKKKSPVPVETLKDVKKELTY 573
Query: 319 QVDTLKDMLLELEEQLAESRRQYEEKNKEFEREK 352
Q L ++ E + + + + E +N+ E K
Sbjct: 574 QNTDLSEIKEEEQVKSTDRKSAVEAQNEVTENPK 607
>gi|212276104 leucine rich repeat (in FLII) interacting protein 1
isoform 5 [Homo sapiens]
Length = 752
Score = 268 bits (686), Expect = 9e-72
Identities = 162/261 (62%), Positives = 181/261 (69%), Gaps = 36/261 (13%)
Query: 207 RASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKE 266
R VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIK
Sbjct: 47 RQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIK- 105
Query: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 326
DSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM
Sbjct: 106 -----------------------DSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 142
Query: 327 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQ 386
LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE+ + +
Sbjct: 143 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSE 202
Query: 387 ASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDL--REEVVMLKEEL----KK 440
++ E SD + ++ G + KE ++++S D R V +K E+ K
Sbjct: 203 IATNGETSDTLNNVGYQ----GPTKMTKEELNALKSTGDGTLGRASEVEVKNEIVANVGK 258
Query: 441 HGIILNSEIATNGETSDTLNN 461
I+ N+E T DT+ +
Sbjct: 259 REILHNTE--KEQHTEDTVKD 277
Score = 59.3 bits (142), Expect = 1e-08
Identities = 34/48 (70%), Positives = 40/48 (83%), Gaps = 1/48 (2%)
Query: 22 EDDALNQIARE-AEARLAAKRAARAEAREIRMKELERQQKEIYQVQKK 68
E D L+ A++ AEARLAAKRAARAEAREIRMKELERQQKE+ + +K
Sbjct: 11 EIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEK 58
Score = 34.3 bits (77), Expect = 0.36
Identities = 33/154 (21%), Positives = 63/154 (40%), Gaps = 4/154 (2%)
Query: 199 ASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE 258
A + A ++ V + E++ E G R+ + S GT ++DT+
Sbjct: 426 AEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQ 485
Query: 259 ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMY 318
++KE +E K D +G+ + + K + + K KK+ V L + K Y
Sbjct: 486 NEPLDMKEPDEEK---SDQQGEALDS-SQKKTKNKKKKNKKKKSPVPVETLKDVKKELTY 541
Query: 319 QVDTLKDMLLELEEQLAESRRQYEEKNKEFEREK 352
Q L ++ E + + + + E +N+ E K
Sbjct: 542 QNTDLSEIKEEEQVKSTDRKSAVEAQNEVTENPK 575
>gi|8923224 leucine rich repeat (in FLII) interacting protein 2
isoform 2 [Homo sapiens]
Length = 400
Score = 239 bits (611), Expect = 4e-63
Identities = 140/318 (44%), Positives = 206/318 (64%), Gaps = 30/318 (9%)
Query: 327 LLELEEQLAESRRQYEE---KNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQ 383
L EL E L+E +Y++ N + + EK+ L +Q +K+ ++++EE + E +
Sbjct: 109 LSELRESLSEVEEKYKKAMVSNAQLDNEKNN---LIYQVDTLKDVIEEQEEQMAEFYREN 165
Query: 384 QKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGI 443
++++ LERQK ++ + ++L+E + E ++KHG+
Sbjct: 166 EEKSKE--------------------LERQKHMCSVLQHKMEELKEGLRQRDELIEKHGL 205
Query: 444 ILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQ 503
++ + NG+ S + T +++E L+S G+G LD+RL+KL E+E LL Q
Sbjct: 206 VIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 262
Query: 504 IKKLKGQLEE-RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQE 562
I+KLK QLEE RQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+
Sbjct: 263 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 322
Query: 563 ITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHL 622
IT LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL
Sbjct: 323 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 382
Query: 623 VKRLEKMKANRSALLSQQ 640
KRLEKMKANR+ALL+QQ
Sbjct: 383 AKRLEKMKANRTALLAQQ 400
Score = 99.4 bits (246), Expect = 9e-21
Identities = 57/111 (51%), Positives = 73/111 (65%), Gaps = 15/111 (13%)
Query: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE+
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 63 YQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGS 113
+ K Y +E Y+R S RN++++ + RGS
Sbjct: 61 DEKSDKQY---------------AENYTRPSSRNSASATTPLSGNSSRRGS 96
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 85.9 bits (211), Expect = 1e-16
Identities = 127/618 (20%), Positives = 251/618 (40%), Gaps = 93/618 (15%)
Query: 32 EAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSR 91
E A+L ++ A EA + + +L+ ++ ++ + K L+ + D+E +E ++
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 1047
Query: 92 RSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSC 151
RN + D +++ S L + Q L+ R +
Sbjct: 1048 DLERNKRKLEGDLKLAQESILDLEND---------------------KQQLDERLKKKDF 1086
Query: 152 LYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPV 211
Y ++ V DE + G + +A E + RA+
Sbjct: 1087 EYC------QLQSKVEDEQTLGLQFQKKIKELQARIE---------ELEEEIEAERATRA 1131
Query: 212 VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELK 271
E+ D+ +R + LS L GG +S T I ++ + +K +L+
Sbjct: 1132 KTEKQRSDY----ARELEELSER-LEEAGGVTS------TQIELNKKREAEFLKLRRDLE 1180
Query: 272 DQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDML---- 327
+ E K+ DS+AE+ E+ +L+ EK+ F ++D L +
Sbjct: 1181 EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Query: 328 -----LE-----LEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE 377
LE LE+QL+E+R + EE + S LQ + E+ L+++E ++
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 378 EIRQLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKE 436
++ + +Q E+ L+E + K+ AL+ + D +R + ++ +E L+
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Query: 437 ELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDE 496
L K NSE+A TK E +A++ T + L+ KKL
Sbjct: 1361 ALSK----ANSEVA-----------------QWRTKYETDAIQRTEE--LEEAKKKLAQR 1397
Query: 497 RECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE----NGTDMHVMDLQRDANRQISDL 552
+ EQ++ + + +K + ED +++ N + QR+ ++ +++
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 553 KFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKT 612
K K +S+ E+ A + L +++ + K+A E A + +K E + L++E+ D T
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI---ADLT 1514
Query: 613 EELEVSNGHLVKRLEKMK 630
E++ NG + LEK +
Sbjct: 1515 EQI-AENGKTIHELEKSR 1531
Score = 70.5 bits (171), Expect = 5e-12
Identities = 99/430 (23%), Positives = 195/430 (45%), Gaps = 55/430 (12%)
Query: 234 ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMK---- 289
A ASL T R + +D E + N L + + + + L E K
Sbjct: 1410 AKCASLEKTKQRLQGEVEDLMVDVERA-------NSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 290 DSLAEVEEKYKKAMVSNAQLDNEKTNF---MYQVDTLKDMLLELEEQLAESRRQYEEKNK 346
+S AE+E K++ + +L K + + Q++T+K LE+++A+ Q E K
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 347 EFEREKHAHSILQFQFAEVKEALKQREEMLE-EIRQLQQKQASSIREISDLQETIEWKDK 405
+ + ++ + A+++ AL++ E LE E ++ + Q + S++ I KD+
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582
Query: 406 KIGAL----ERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA---TNGETSDT 458
+I L +R E S R E + LK+ K G + EI N + ++T
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK--KMEGDLNEIEIQLSHANRQAAET 1640
Query: 459 LNNV-GYQGPTKMTKEEL-NALKSTGDGTLDIRLKKLVDEREC--LLEQIKKLKGQLEER 514
L ++ QG K T+ L +AL+ G D++ + + ER L ++++L+ LE+
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALR----GQEDLKEQLAIVERRANLLQAEVEELRATLEQT 1696
Query: 515 QKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR-L 573
++ KL +E ++L++ + ++ Q N + K KL ++ + ++ R
Sbjct: 1697 ERARKL----AEQELLDSNERVQLLHTQ---NTSLIHTKKKLETDLMQLQSEVEDASRDA 1749
Query: 574 ESQVSRYKSAAENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNG 620
+ + K A +A + +ELK E K+ L+ ++L+ LD+ E+L + G
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1809
Query: 621 HLVKRLEKMK 630
K+++K++
Sbjct: 1810 K--KQIQKLE 1817
Score = 62.4 bits (150), Expect = 1e-09
Identities = 81/398 (20%), Positives = 170/398 (42%), Gaps = 80/398 (20%)
Query: 266 ELNELKDQIQDVEG---KYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
E +L+ +++D + ++ + +KE++ + E+EE+ + + A+ + +++++ +++
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE 1146
Query: 323 LKDMLLEL--------------EEQLAESRRQYEEKNKEFE------REKHAHSILQFQF 362
L + L E E + + RR EE + E R+KHA S+ +
Sbjct: 1147 LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE--- 1203
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIR-EISDLQETIEWKDKKIGALERQKEFFDSVR 421
L ++ + L+ ++Q +K+ S + EI DL ++E K LE+ +
Sbjct: 1204 ------LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
SE EE+ EL L +E GE S L KE +
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEA---GELSRQLEE----------KESI------ 1298
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
+ +L ++ +Q ++LK QLEE K + +
Sbjct: 1299 --------VSQLSRSKQAFTQQTEELKRQLEEENKA------------------KNALAH 1332
Query: 542 QRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAAE-NAEKIEDELKAEKR 599
++R DL + + EQE A L++ + + S+V+++++ E +A + +EL+ K+
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALL 637
KL + L+ + ++ E + L K ++++ L+
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430
Score = 62.0 bits (149), Expect = 2e-09
Identities = 81/408 (19%), Positives = 168/408 (41%), Gaps = 32/408 (7%)
Query: 253 ISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE 312
+ + +A + + E DQ+ + + +KE+ + + EE + +L++E
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 313 KTNFMYQVDTLKDMLLELEEQ----------LAESRRQYEEKNKEFEREKHAHSILQFQF 362
+ +D L+ L ++E++ L E +E + REK A LQ
Sbjct: 948 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA---LQEAH 1004
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDS--- 419
+ + L+ E +++ L + ++ +++ DL+ ++E + K LER K +
Sbjct: 1005 QQALDDLQAEE---DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Query: 420 -VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNAL 478
+ DL + L E LKK ++ + E TL + +Q K + + L
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEY-CQLQSKVEDEQTL-GLQFQKKIKELQARIEEL 1119
Query: 479 KSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLD---NLRSEDDVLENGTD 535
+ + R K +R ++++L +LEE + N + E + L+ D
Sbjct: 1120 EEEIEAERATR-AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
Query: 536 MHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR----LESQVSRYKSAAENAEKIE 591
+ LQ +A ++ L+ K A S E+ N+ R LE + S +K ++
Sbjct: 1179 LEEATLQHEA--MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 592 DELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+ + K L++ R+ D+ E N + + L ++ +S L ++
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284
Score = 57.0 bits (136), Expect = 5e-08
Identities = 65/264 (24%), Positives = 119/264 (45%), Gaps = 42/264 (15%)
Query: 385 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 444
K A + +E++ ++E + + K+ ++R +L E++V L +E +
Sbjct: 842 KSAETEKEMATMKEEFQ----------KTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ 891
Query: 445 LNSE---IATNGETSDTLNNVGYQGPTKMTK--------EELNALKSTGDGTLD---IRL 490
+ +E + E D L +Q K+ + EE+NA + L+ L
Sbjct: 892 VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Query: 491 KKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRD------ 544
KK +D+ E L +++K K E + K NL E +G D + L R+
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVK-----NLTEE----LSGLDETIAKLTREKKALQE 1002
Query: 545 ANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRE 604
A++Q D L E ++ +L + +LE QV +S+ E +K+ +L+ KRKL+ +
Sbjct: 1003 AHQQALD---DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD 1059
Query: 605 LRSALDKTEELEVSNGHLVKRLEK 628
L+ A + +LE L +RL+K
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKK 1083
Score = 54.3 bits (129), Expect = 3e-07
Identities = 72/332 (21%), Positives = 143/332 (43%), Gaps = 56/332 (16%)
Query: 301 KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF 360
K ++ +A+ + E + KD L + E + R++ EEK +EK+ LQ
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAK----RKELEEKLVTLVQEKND---LQL 890
Query: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDS- 419
Q E L EE +++ + + + + I+E+++ E E + ++ A +R+ E S
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 420 VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 479
++ + DDL E+ + K E +KH T N V K EEL+ L
Sbjct: 951 LKKDIDDL--ELTLAKVEKEKHA---------------TENKV------KNLTEELSGLD 987
Query: 480 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 539
T + KL E++ L E ++ LD+L++E+D + + +
Sbjct: 988 ET--------IAKLTREKKALQEAHQQA------------LDDLQAEEDKVNS-----LN 1022
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+ +Q+ DL+ L + ++ LE+N +LE + + + + E + +L +
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
K E K E+ + K++++++A
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114
Score = 54.3 bits (129), Expect = 3e-07
Identities = 79/378 (20%), Positives = 168/378 (44%), Gaps = 37/378 (9%)
Query: 258 EASIREIK-ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 316
EA I I+ EL ++K +I + + ++++K + E + A+ + + NE
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
Query: 317 MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEML 376
+++ L E+E QL+ + RQ E K + L+ + +AL+ +E++
Sbjct: 1616 KKKME---GDLNEIEIQLSHANRQAAETLKHL---RSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 377 EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDL----REEVV 432
E++ ++++ E+ +L+ T+E ++ E+ E DS +ER L ++
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQ--ELLDS--NERVQLLHTQNTSLI 1725
Query: 433 MLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKK 492
K++L+ + L SE+ + S N + +T + A + + L++
Sbjct: 1726 HTKKKLETDLMQLQSEVE---DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1782
Query: 493 LVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDL 552
+ ++ L + +K L+ +L+E +++ L + + LE +L+ + + +
Sbjct: 1783 M---KKNLEQTVKDLQHRLDEAEQLA-LKGGKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 553 KFKLAKSEQEITAL-------EQNVIRLES-------QVSRYKSAAENAEKIEDELKAEK 598
K L K E+ + L +NV+RL+ +V YK AE A++ + +
Sbjct: 1839 K-GLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKF 1897
Query: 599 RKLQRELRSALDKTEELE 616
RK Q EL A ++ + E
Sbjct: 1898 RKAQHELEEAEERADIAE 1915
Score = 53.5 bits (127), Expect = 6e-07
Identities = 97/446 (21%), Positives = 168/446 (37%), Gaps = 89/446 (19%)
Query: 217 EKDFTEKGSRNMP----GLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE--- 269
EK TE +N+ GL T+A L D +A ++ LN+
Sbjct: 968 EKHATENKVKNLTEELSGLDE-TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKS 1026
Query: 270 -LKDQIQDVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
L+ Q++D+E Q K +++ + ++E K A S L+N+K
Sbjct: 1027 KLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ----------- 1075
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
+L+E+L + +Y + + E E+ LQFQ ++KE + EE+ EEI +
Sbjct: 1076 ---QLDERLKKKDFEYCQLQSKVEDEQTLG--LQFQ-KKIKELQARIEELEEEIEAERAT 1129
Query: 386 QASSIREISD----LQETIEWKDKKIGALERQKEFFDSVRSE----RDDLREEVV----M 433
+A + ++ SD L+E E ++ G Q E +E R DL E + M
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM 1189
Query: 434 LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKL 493
+ KKH +A GE D L V K++L KS K
Sbjct: 1190 VAALRKKHA----DSVAELGEQIDNLQRV---------KQKLEKEKS--------EFKLE 1228
Query: 494 VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
+D+ +E + K K LE+ + R Q+S+ +
Sbjct: 1229 IDDLSSSMESVSKSKANLEK---------------------------ICRTLEDQLSEAR 1261
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
K + ++ ++ L RL+++ E E I +L K+ ++ + E
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Query: 614 ELEVSNGHLVKRLEKMKANRSALLSQ 639
E + L L+ + + L Q
Sbjct: 1322 EENKAKNALAHALQSSRHDCDLLREQ 1347
Score = 36.2 bits (82), Expect = 0.095
Identities = 45/210 (21%), Positives = 94/210 (44%), Gaps = 19/210 (9%)
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA-LKSTGDG 484
+ +E+ +KEE +K L A E + L + + K +L +++ +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQE------KNDLQLQVQAESEN 898
Query: 485 TLDI--RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQ 542
LD R +L+ + L +IK++ + E+ ++I L ++ LE+ +L+
Sbjct: 899 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA--ELTAKKRKLED----ECSELK 952
Query: 543 RDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQ 602
+D I DL+ LAK E+E A E V L ++S + + L+ ++
Sbjct: 953 KD----IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL 1008
Query: 603 RELRSALDKTEELEVSNGHLVKRLEKMKAN 632
+L++ DK L + L +++E ++++
Sbjct: 1009 DDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Score = 30.8 bits (68), Expect = 4.0
Identities = 23/134 (17%), Positives = 63/134 (47%), Gaps = 4/134 (2%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
K++ +L+ +I+++E + K+ +S+ + + ++ Q + ++ N + L+
Sbjct: 1811 KQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL----RLQ 1866
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 384
D++ +L+ ++ +RQ EE +++ Q + E +E E + ++R +
Sbjct: 1867 DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926
Query: 385 KQASSIREISDLQE 398
SS + + +E
Sbjct: 1927 DFTSSRMVVHESEE 1940
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/443 (21%), Positives = 188/443 (42%), Gaps = 51/443 (11%)
Query: 212 VEERPEKDFTEKGSRNMPGLSAATLA-SLGGTSSRRGSGDTSISIDTEASIREIKELNEL 270
+EE E+ E+ SR + L+ L S R + S E + + E ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 271 KDQIQDV----EGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD----- 321
+ +++ E K+ DS+AE+ E+ +L+ EK+ ++D
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 322 ---------TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
L+ M LE+QL+E + + EE+ + LQ + E L ++
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 373 EEMLEEIRQLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
E ++ ++ + +Q I E+ L+E I+ K+ AL+ + D +R + ++ +E
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESK 1360
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
L+ L K N+E+A TK E +A++ T + L+ K
Sbjct: 1361 AELQRALSK----ANTEVA-----------------QWRTKYETDAIQRTEE--LEEAKK 1397
Query: 492 KLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE----NGTDMHVMDLQRDANR 547
KL + E ++ + + +K + ED +L+ N + QR+ ++
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 548 QISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRS 607
+++ K K ++ E+ A ++ L +++ + K+A E + + LK E + LQ+E+
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS- 1516
Query: 608 ALDKTEELEVSNGHLVKRLEKMK 630
D TE++ G + LEK+K
Sbjct: 1517 --DLTEQI-AEGGKRIHELEKIK 1536
Score = 68.6 bits (166), Expect = 2e-11
Identities = 86/391 (21%), Positives = 172/391 (43%), Gaps = 80/391 (20%)
Query: 266 ELNELKDQIQDVEGKYMQ---GLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
E++ L+ +I+D + +Q +KE++ + E+EE+ + S A+ + ++++ +++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 323 LKDMLLEL--------------EEQLAESRRQYEEKNKEFE------REKHAHSILQFQF 362
+ + L E E + + RR EE + E R+KHA S+ +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE--- 1208
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIR-EISDLQETIEWKDKKIGALERQKEFFDSVR 421
L ++ + L+ ++Q +K+ S ++ EI DL +E K G LE+ +
Sbjct: 1209 ------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
SE EE L +L L +E +GE S L+ KE L + S
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTE---SGEFSRQLDE----------KEALVSQLSR 1309
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
G ++ +QI++LK QLEE ++ H +
Sbjct: 1310 G--------------KQAFTQQIEELKRQLEE--------------EIKAKNALAHAL-- 1339
Query: 542 QRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAAE-NAEKIEDELKAEKR 599
++R DL + + EQE A L++ + + ++V+++++ E +A + +EL+ K+
Sbjct: 1340 --QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMK 630
KL + L++A + E + L K ++++
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Score = 66.6 bits (161), Expect = 7e-11
Identities = 76/403 (18%), Positives = 175/403 (43%), Gaps = 59/403 (14%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
ELN++K ++ + + + ++K + + E + + + + N+ +++
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME---G 1626
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
L E+E QL + R E + + ++ IL+ + +AL+ +E++ E++ ++++
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNY---RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683
Query: 386 QASSIREISDLQETIEWKDKK-------------------------IGALERQKEFFDSV 420
EI +L+ T+E ++ I ++ + +
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM 1743
Query: 421 RSERDDLREEVVMLKEELKK---HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA 477
+ E +D+ +E +E+ KK ++ E+ +TS L + K ++ +
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-----KKNMEQTVKD 1798
Query: 478 LKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMH 537
L+ D + LK + + L ++++L+G++E QK R+ + V G H
Sbjct: 1799 LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK-------RNAEAV--KGLRKH 1849
Query: 538 VMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAE 597
R++ +L ++ + + I L+ V +L+++V YK AE AE+ + A+
Sbjct: 1850 --------ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 598 KRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
RKLQ EL A E +++ + K K + + ++S++
Sbjct: 1902 FRKLQHELEEA---EERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 64.7 bits (156), Expect = 3e-10
Identities = 93/423 (21%), Positives = 193/423 (45%), Gaps = 39/423 (9%)
Query: 234 ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLA 293
A ASL T R + + +D E + L++ + + ++ Q +E A
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH---A 1471
Query: 294 EVEEKYKKAMVSNAQLDNEKTNF---MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFER 350
E+E K+A +L K + + Q++TLK L++++++ Q E K
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 351 EKHAHSILQFQFAEVKEALKQREEMLE-EIRQLQQKQASSIREISDLQETIEWKDKKIGA 409
+ ++ + E++ AL++ E LE E ++ + Q + S++ I KD++I
Sbjct: 1532 LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 410 LERQK-EFFDSVRSERD-DLREEVVMLKEELKKHGIILNSEIA---TNGETSDTLNNV-G 463
L+R +S++S D ++R ++ + K G + EI N ++ L N
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 464 YQGPTKMTKEEL-NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDN 522
QG K T+ L +AL+S D L +L + L +I++L+ LE+ ++ K+
Sbjct: 1652 TQGILKDTQIHLDDALRSQED--LKEQLAMVERRANLLQAEIEELRATLEQTERSRKI-- 1707
Query: 523 LRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR-LESQVSRYK 581
+E ++L+ + ++ Q N + + K KL ++ +++++ + + K
Sbjct: 1708 --AEQELLDASERVQLLHTQ---NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762
Query: 582 SAAENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNGHLVKRLEK 628
A +A + +ELK E K+ ++ ++L+ LD+ E+L + G K+++K
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK--KQIQK 1820
Query: 629 MKA 631
++A
Sbjct: 1821 LEA 1823
Score = 61.6 bits (148), Expect = 2e-09
Identities = 112/481 (23%), Positives = 196/481 (40%), Gaps = 101/481 (20%)
Query: 217 EKDFTEKGSRN----MPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE--- 269
EK TE +N M GL T+A L D +A ++ L +
Sbjct: 973 EKHATENKVKNLTEEMAGLDE-TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031
Query: 270 -LKDQIQDVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
L+ Q+ D+EG Q K +++ + ++E K A S ++NEK
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ----------- 1080
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
+L+E+L ++++E N + + E +Q Q ++KE + EE+ EEI +
Sbjct: 1081 ---QLDEKL--KKKEFEISNLQSKIEDEQALGIQLQ-KKIKELQARIEELEEEIEAERAS 1134
Query: 386 QASSIREISDLQETIEWKDKKI----GALERQKEFFDSVRSERDDLR---EEVVMLKEEL 438
+A + ++ SDL +E +++ GA Q E +E +R EE + E
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194
Query: 439 -----KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKL 493
KKH +A GE D L V K++L KS +K
Sbjct: 1195 AATLRKKHA----DSVAELGEQIDNLQRV---------KQKLEKEKS--------EMKME 1233
Query: 494 VDERECLLEQIKKLKGQLEE-----RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDA--- 545
+D+ +E + K KG LE+ ++ +L + E L N LQ ++
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEF 1293
Query: 546 NRQISD---LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENA------------EKI 590
+RQ+ + L +L++ +Q T + + R + + K+A +A E+
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 591 EDELKAEKRKLQRELRSA---------------LDKTEELEVSNGHLVKRLEKMKANRSA 635
E+E ++ K +LQR L A + +TEELE + L +RL+ + + A
Sbjct: 1354 EEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 636 L 636
+
Sbjct: 1413 V 1413
Score = 58.9 bits (141), Expect = 1e-08
Identities = 90/437 (20%), Positives = 184/437 (42%), Gaps = 54/437 (12%)
Query: 244 SRRGSGDTSISIDTEASIREIK-ELNELKDQIQDVEGKYMQGLKE--------------- 287
+ R + I+ + A R+++ E +ELK I D+E + KE
Sbjct: 929 TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 988
Query: 288 --MKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKN 345
+ +++A++ ++ K ++ Q ++ +V+TL ++LE+Q+ + E++
Sbjct: 989 AGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1048
Query: 346 K---EFEREKHAHS----ILQFQFAEVKEALKQREEMLE----EIRQLQQK----QASSI 390
K + ER K + Q +++ +Q +E L+ EI LQ K QA I
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 391 ---REISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNS 447
++I +LQ IE +++I E ++ +R DL E+ + E L++ G ++
Sbjct: 1109 QLQKKIKELQARIEELEEEI---EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 448 EIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI--- 504
+I N + + + +L + T KK D L EQI
Sbjct: 1166 QIEMNKKREAEFQKM---------RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 505 KKLKGQLEERQKIGKL--DNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQE 562
+++K +LE+ + K+ D+L S + + ++ + R Q+S+LK K + ++
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-NLEKMCRTLEDQLSELKSKEEEQQRL 1275
Query: 563 ITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHL 622
I L RL+++ + + E + +L K+ +++ + EE + L
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 623 VKRLEKMKANRSALLSQ 639
L+ + + L Q
Sbjct: 1336 AHALQSSRHDCDLLREQ 1352
Score = 57.8 bits (138), Expect = 3e-08
Identities = 66/296 (22%), Positives = 133/296 (44%), Gaps = 43/296 (14%)
Query: 344 KNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWK 403
K+ E E+E + ++ +F ++K+ L + E +E L++K + ++E +DLQ ++ +
Sbjct: 847 KSAETEKEM---ATMKEEFQKIKDELAKSEAKRKE---LEEKMVTLLKEKNDLQLQVQAE 900
Query: 404 DKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVG 463
+ + E + D L + + L+ ++K E+ E + +N
Sbjct: 901 AEGLADAEERC----------DQLIKTKIQLEAKIK--------EVTERAEDEEEIN--- 939
Query: 464 YQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNL 523
EL A K + LKK +D+ E L +++K K E + K + +
Sbjct: 940 ---------AELTAKKRKLEDECS-ELKKDIDDLELTLAKVEKEKHATENKVK-NLTEEM 988
Query: 524 RSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSA 583
D+ + T LQ + + DL+ + E ++ L + I+LE QV + +
Sbjct: 989 AGLDETIAKLTK-EKKALQEAHQQTLDDLQAE----EDKVNTLTKAKIKLEQQVDDLEGS 1043
Query: 584 AENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
E +K+ +L+ KRKL+ +L+ A + ++E L ++L+K + S L S+
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/332 (21%), Positives = 146/332 (43%), Gaps = 56/332 (16%)
Query: 301 KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF 360
K ++ +A+ + E + +KD L + E + R++ EEK +EK+ LQ
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAK----RKELEEKMVTLLKEKND---LQL 895
Query: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDS- 419
Q E L EE +++ + + + + I+E+++ E E + ++ A +R+ E S
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 420 VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 479
++ + DDL E+ + K E +KH T N V K EE+ L
Sbjct: 956 LKKDIDDL--ELTLAKVEKEKHA---------------TENKV------KNLTEEMAGLD 992
Query: 480 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 539
T + KL E++ L E ++ LD+L++E+D + T +
Sbjct: 993 ET--------IAKLTKEKKALQEAHQQT------------LDDLQAEEDKVNTLTKAKIK 1032
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+Q+ DL+ L + ++ LE+ +LE + + + + E + +L + +
Sbjct: 1033 -----LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
K + E+ + K E+ + L K++++++A
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Score = 56.2 bits (134), Expect = 9e-08
Identities = 73/401 (18%), Positives = 164/401 (40%), Gaps = 37/401 (9%)
Query: 253 ISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE 312
+ + +A + + E DQ+ + + +KE+ + + EE + +L++E
Sbjct: 893 LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 952
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
+ +D L+ L ++E++ + E K K E + + K+AL++
Sbjct: 953 CSELKKDIDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 373 EEMLEEIRQLQQKQASSI--------REISDLQETIEWKDKKIGALERQKEFFDS----V 420
+ + Q ++ + +++ +++ DL+ ++E + K LER K +
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 421 RSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS 480
+ D+ E L E+LKK EI+ + +G Q K+ +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKK----EFEISNLQSKIEDEQALGIQLQKKIKE-------- 1116
Query: 481 TGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHV-M 539
L R+++L +E E E+ + K + + +L+ + + T + M
Sbjct: 1117 -----LQARIEELEEEIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+ +R+A Q + A + E TA +S V+ +N ++++ +L+ EK
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS-VAELGEQIDNLQRVKQKLEKEKS 1228
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+++ E+ E + + G+L K ++ S L S++
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.2 bits (191), Expect = 2e-14
Identities = 95/443 (21%), Positives = 188/443 (42%), Gaps = 51/443 (11%)
Query: 212 VEERPEKDFTEKGSRNMPGLSAATLA-SLGGTSSRRGSGDTSISIDTEASIREIKELNEL 270
+EE E+ E+ SR + L+ L S R + S E + + E ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 271 KDQIQDV----EGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD----- 321
+ +++ E K+ DS+AE+ E+ +L+ EK+ ++D
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 322 ---------TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
L+ M LE+QL+E + + EE+ + LQ + E L ++
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 373 EEMLEEIRQLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
E ++ ++ + +Q I E+ L+E I+ K+ AL+ + D +R + ++ +E
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESK 1360
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
L+ L K N+E+A TK E +A++ T + L+ K
Sbjct: 1361 AELQRALSK----ANTEVA-----------------QWRTKYETDAIQRTEE--LEEAKK 1397
Query: 492 KLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE----NGTDMHVMDLQRDANR 547
KL + E ++ + + +K + ED +L+ N + QR+ ++
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 548 QISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRS 607
+++ K K ++ E+ A ++ L +++ + K+A E + + LK E + LQ+E+
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS- 1516
Query: 608 ALDKTEELEVSNGHLVKRLEKMK 630
D TE++ G + LEK+K
Sbjct: 1517 --DLTEQI-AEGGKRIHELEKIK 1536
Score = 68.6 bits (166), Expect = 2e-11
Identities = 86/391 (21%), Positives = 172/391 (43%), Gaps = 80/391 (20%)
Query: 266 ELNELKDQIQDVEGKYMQ---GLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
E++ L+ +I+D + +Q +KE++ + E+EE+ + S A+ + ++++ +++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 323 LKDMLLEL--------------EEQLAESRRQYEEKNKEFE------REKHAHSILQFQF 362
+ + L E E + + RR EE + E R+KHA S+ +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE--- 1208
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIR-EISDLQETIEWKDKKIGALERQKEFFDSVR 421
L ++ + L+ ++Q +K+ S ++ EI DL +E K G LE+ +
Sbjct: 1209 ------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
SE EE L +L L +E +GE S L+ KE L + S
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTE---SGEFSRQLDE----------KEALVSQLSR 1309
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
G ++ +QI++LK QLEE ++ H +
Sbjct: 1310 G--------------KQAFTQQIEELKRQLEE--------------EIKAKNALAHAL-- 1339
Query: 542 QRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAAE-NAEKIEDELKAEKR 599
++R DL + + EQE A L++ + + ++V+++++ E +A + +EL+ K+
Sbjct: 1340 --QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMK 630
KL + L++A + E + L K ++++
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Score = 66.6 bits (161), Expect = 7e-11
Identities = 76/403 (18%), Positives = 175/403 (43%), Gaps = 59/403 (14%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
ELN++K ++ + + + ++K + + E + + + + N+ +++
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME---G 1626
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
L E+E QL + R E + + ++ IL+ + +AL+ +E++ E++ ++++
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNY---RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683
Query: 386 QASSIREISDLQETIEWKDKK-------------------------IGALERQKEFFDSV 420
EI +L+ T+E ++ I ++ + +
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM 1743
Query: 421 RSERDDLREEVVMLKEELKK---HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA 477
+ E +D+ +E +E+ KK ++ E+ +TS L + K ++ +
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-----KKNMEQTVKD 1798
Query: 478 LKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMH 537
L+ D + LK + + L ++++L+G++E QK R+ + V G H
Sbjct: 1799 LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK-------RNAEAV--KGLRKH 1849
Query: 538 VMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAE 597
R++ +L ++ + + I L+ V +L+++V YK AE AE+ + A+
Sbjct: 1850 --------ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 598 KRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
RKLQ EL A E +++ + K K + + ++S++
Sbjct: 1902 FRKLQHELEEA---EERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 64.7 bits (156), Expect = 3e-10
Identities = 93/423 (21%), Positives = 193/423 (45%), Gaps = 39/423 (9%)
Query: 234 ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLA 293
A ASL T R + + +D E + L++ + + ++ Q +E A
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH---A 1471
Query: 294 EVEEKYKKAMVSNAQLDNEKTNF---MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFER 350
E+E K+A +L K + + Q++TLK L++++++ Q E K
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 351 EKHAHSILQFQFAEVKEALKQREEMLE-EIRQLQQKQASSIREISDLQETIEWKDKKIGA 409
+ ++ + E++ AL++ E LE E ++ + Q + S++ I KD++I
Sbjct: 1532 LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 410 LERQK-EFFDSVRSERD-DLREEVVMLKEELKKHGIILNSEIA---TNGETSDTLNNV-G 463
L+R +S++S D ++R ++ + K G + EI N ++ L N
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Query: 464 YQGPTKMTKEEL-NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDN 522
QG K T+ L +AL+S D L +L + L +I++L+ LE+ ++ K+
Sbjct: 1652 TQGILKDTQIHLDDALRSQED--LKEQLAMVERRANLLQAEIEELRATLEQTERSRKI-- 1707
Query: 523 LRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR-LESQVSRYK 581
+E ++L+ + ++ Q N + + K KL ++ +++++ + + K
Sbjct: 1708 --AEQELLDASERVQLLHTQ---NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAK 1762
Query: 582 SAAENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNGHLVKRLEK 628
A +A + +ELK E K+ ++ ++L+ LD+ E+L + G K+++K
Sbjct: 1763 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK--KQIQK 1820
Query: 629 MKA 631
++A
Sbjct: 1821 LEA 1823
Score = 61.6 bits (148), Expect = 2e-09
Identities = 112/481 (23%), Positives = 196/481 (40%), Gaps = 101/481 (20%)
Query: 217 EKDFTEKGSRN----MPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE--- 269
EK TE +N M GL T+A L D +A ++ L +
Sbjct: 973 EKHATENKVKNLTEEMAGLDE-TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031
Query: 270 -LKDQIQDVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
L+ Q+ D+EG Q K +++ + ++E K A S ++NEK
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ----------- 1080
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
+L+E+L ++++E N + + E +Q Q ++KE + EE+ EEI +
Sbjct: 1081 ---QLDEKL--KKKEFEISNLQSKIEDEQALGIQLQ-KKIKELQARIEELEEEIEAERAS 1134
Query: 386 QASSIREISDLQETIEWKDKKI----GALERQKEFFDSVRSERDDLR---EEVVMLKEEL 438
+A + ++ SDL +E +++ GA Q E +E +R EE + E
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194
Query: 439 -----KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKL 493
KKH +A GE D L V K++L KS +K
Sbjct: 1195 AATLRKKHA----DSVAELGEQIDNLQRV---------KQKLEKEKS--------EMKME 1233
Query: 494 VDERECLLEQIKKLKGQLEE-----RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDA--- 545
+D+ +E + K KG LE+ ++ +L + E L N LQ ++
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEF 1293
Query: 546 NRQISD---LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENA------------EKI 590
+RQ+ + L +L++ +Q T + + R + + K+A +A E+
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 591 EDELKAEKRKLQRELRSA---------------LDKTEELEVSNGHLVKRLEKMKANRSA 635
E+E ++ K +LQR L A + +TEELE + L +RL+ + + A
Sbjct: 1354 EEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 636 L 636
+
Sbjct: 1413 V 1413
Score = 58.9 bits (141), Expect = 1e-08
Identities = 90/437 (20%), Positives = 184/437 (42%), Gaps = 54/437 (12%)
Query: 244 SRRGSGDTSISIDTEASIREIK-ELNELKDQIQDVEGKYMQGLKE--------------- 287
+ R + I+ + A R+++ E +ELK I D+E + KE
Sbjct: 929 TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 988
Query: 288 --MKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKN 345
+ +++A++ ++ K ++ Q ++ +V+TL ++LE+Q+ + E++
Sbjct: 989 AGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1048
Query: 346 K---EFEREKHAHS----ILQFQFAEVKEALKQREEMLE----EIRQLQQK----QASSI 390
K + ER K + Q +++ +Q +E L+ EI LQ K QA I
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 391 ---REISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNS 447
++I +LQ IE +++I E ++ +R DL E+ + E L++ G ++
Sbjct: 1109 QLQKKIKELQARIEELEEEI---EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1165
Query: 448 EIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI--- 504
+I N + + + +L + T KK D L EQI
Sbjct: 1166 QIEMNKKREAEFQKM---------RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 505 KKLKGQLEERQKIGKL--DNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQE 562
+++K +LE+ + K+ D+L S + + ++ + R Q+S+LK K + ++
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-NLEKMCRTLEDQLSELKSKEEEQQRL 1275
Query: 563 ITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHL 622
I L RL+++ + + E + +L K+ +++ + EE + L
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 623 VKRLEKMKANRSALLSQ 639
L+ + + L Q
Sbjct: 1336 AHALQSSRHDCDLLREQ 1352
Score = 57.8 bits (138), Expect = 3e-08
Identities = 66/296 (22%), Positives = 133/296 (44%), Gaps = 43/296 (14%)
Query: 344 KNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWK 403
K+ E E+E + ++ +F ++K+ L + E +E L++K + ++E +DLQ ++ +
Sbjct: 847 KSAETEKEM---ATMKEEFQKIKDELAKSEAKRKE---LEEKMVTLLKEKNDLQLQVQAE 900
Query: 404 DKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVG 463
+ + E + D L + + L+ ++K E+ E + +N
Sbjct: 901 AEGLADAEERC----------DQLIKTKIQLEAKIK--------EVTERAEDEEEIN--- 939
Query: 464 YQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNL 523
EL A K + LKK +D+ E L +++K K E + K + +
Sbjct: 940 ---------AELTAKKRKLEDECS-ELKKDIDDLELTLAKVEKEKHATENKVK-NLTEEM 988
Query: 524 RSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSA 583
D+ + T LQ + + DL+ + E ++ L + I+LE QV + +
Sbjct: 989 AGLDETIAKLTK-EKKALQEAHQQTLDDLQAE----EDKVNTLTKAKIKLEQQVDDLEGS 1043
Query: 584 AENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
E +K+ +L+ KRKL+ +L+ A + ++E L ++L+K + S L S+
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/332 (21%), Positives = 146/332 (43%), Gaps = 56/332 (16%)
Query: 301 KAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQF 360
K ++ +A+ + E + +KD L + E + R++ EEK +EK+ LQ
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAK----RKELEEKMVTLLKEKND---LQL 895
Query: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDS- 419
Q E L EE +++ + + + + I+E+++ E E + ++ A +R+ E S
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 420 VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 479
++ + DDL E+ + K E +KH T N V K EE+ L
Sbjct: 956 LKKDIDDL--ELTLAKVEKEKHA---------------TENKV------KNLTEEMAGLD 992
Query: 480 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 539
T + KL E++ L E ++ LD+L++E+D + T +
Sbjct: 993 ET--------IAKLTKEKKALQEAHQQT------------LDDLQAEEDKVNTLTKAKIK 1032
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+Q+ DL+ L + ++ LE+ +LE + + + + E + +L + +
Sbjct: 1033 -----LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
K + E+ + K E+ + L K++++++A
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Score = 56.2 bits (134), Expect = 9e-08
Identities = 73/401 (18%), Positives = 164/401 (40%), Gaps = 37/401 (9%)
Query: 253 ISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE 312
+ + +A + + E DQ+ + + +KE+ + + EE + +L++E
Sbjct: 893 LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 952
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
+ +D L+ L ++E++ + E K K E + + K+AL++
Sbjct: 953 CSELKKDIDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 373 EEMLEEIRQLQQKQASSI--------REISDLQETIEWKDKKIGALERQKEFFDS----V 420
+ + Q ++ + +++ +++ DL+ ++E + K LER K +
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 421 RSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS 480
+ D+ E L E+LKK EI+ + +G Q K+ +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKK----EFEISNLQSKIEDEQALGIQLQKKIKE-------- 1116
Query: 481 TGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHV-M 539
L R+++L +E E E+ + K + + +L+ + + T + M
Sbjct: 1117 -----LQARIEELEEEIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+ +R+A Q + A + E TA +S V+ +N ++++ +L+ EK
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS-VAELGEQIDNLQRVKQKLEKEKS 1228
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+++ E+ E + + G+L K ++ S L S++
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.8 bits (190), Expect = 3e-14
Identities = 126/610 (20%), Positives = 243/610 (39%), Gaps = 77/610 (12%)
Query: 32 EAEARLAAKRAARAEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSR 91
E A+L ++ A EA + + +L+ ++ ++ + K L+ + D+E +E ++
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRM 1050
Query: 92 RSRRNTSASDEDERMSVGSRGSL---RSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGR 148
R + D +++ S + + Q D + +G ++ Q+L + +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQK 1110
Query: 149 PSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARA 208
A R L+E R + S+ S L S A A +
Sbjct: 1111 KIKELQA-------RIEELEE-EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 209 SPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELN 268
+ + + + +K R+ L ATL ++ R S++ EL
Sbjct: 1163 AQIEMNKKREAEFQKMRRD---LEEATLQHEATAATLRKKHADSVA-----------ELG 1208
Query: 269 ELKDQIQDVEGKYMQGLKEMK---DSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
E D +Q V+ K + EMK D LA E KA L+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK-----------------GNLEK 1251
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
M LE+QL+E + + EE+ + + LQ + E L +++ ++ ++ + +Q
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA 1311
Query: 386 QASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 444
I E+ L+E I+ K AL+ + D +R + ++ +E L+ + K
Sbjct: 1312 FTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK---- 1367
Query: 445 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI 504
NSE+A TK E +A++ T + L+ KKL + E +
Sbjct: 1368 ANSEVA-----------------QWRTKYETDAIQRTEE--LEEAKKKLAQRLQDAEEHV 1408
Query: 505 KKLKGQLEERQKIGKLDNLRSED---DVLENGTDMHVMD-LQRDANRQISDLKFKLAKSE 560
+ + + +K + ED DV +D QR+ ++ +++ K K ++
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1468
Query: 561 QEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNG 620
E+ A ++ L +++ + K+A E + + LK E + LQ+E+ D TE++ G
Sbjct: 1469 AELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEIS---DLTEQI-AEGG 1524
Query: 621 HLVKRLEKMK 630
+ LEK+K
Sbjct: 1525 KRIHELEKIK 1534
Score = 66.6 bits (161), Expect = 7e-11
Identities = 93/424 (21%), Positives = 190/424 (44%), Gaps = 41/424 (9%)
Query: 234 ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLA 293
A ASL T R + + ID E + L++ + + ++ Q +E L
Sbjct: 1413 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1472
Query: 294 EVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKH 353
+++ + ++ N + Q++TLK L++++++ Q E K +
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 354 AHSILQFQFAEVKEALKQREEMLEEIR--------QLQQKQASSIREISDLQETI-EWKD 404
++ + +E++ AL++ E LE +L Q ++ R+I++ E I + K
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592
Query: 405 KKIGALERQKEFFDS-VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV- 462
I +E + D+ +RS D +R + M + +L + I LN N ++ L N
Sbjct: 1593 NHIRIVESMQSTLDAEIRSRNDAIRLKKKM-EGDLNEMEIQLNH---ANRMAAEALRNYR 1648
Query: 463 GYQGPTKMTKEEL-NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLD 521
Q K T+ L +AL+S D L +L + L +I++L+ LE+ ++ K+
Sbjct: 1649 NTQAILKDTQLHLDDALRSQED--LKEQLAMVERRANLLQAEIEELRATLEQTERSRKI- 1705
Query: 522 NLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR-LESQVSRY 580
+E ++L+ + ++ Q N + + K KL +I +++I+ + +
Sbjct: 1706 ---AEQELLDASERVQLLHTQ---NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA 1759
Query: 581 KSAAENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNGHLVKRLE 627
K A +A + +ELK E K+ L+ ++L+ LD+ E+L + G K+++
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQ 1817
Query: 628 KMKA 631
K++A
Sbjct: 1818 KLEA 1821
Score = 63.5 bits (153), Expect = 6e-10
Identities = 66/269 (24%), Positives = 123/269 (45%), Gaps = 30/269 (11%)
Query: 385 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 444
K A + +E+++++E E + KE ++R +L E++V L +E +
Sbjct: 845 KSAETEKEMANMKEEFE----------KTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 445 LNSE---IATNGETSDTLNNVGYQGPTKMTK--------EELNALKSTGDGTLD---IRL 490
+ +E +A E D L Q K+ + EE+NA + L+ L
Sbjct: 895 VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 491 KKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQIS 550
KK +D+ E L +++K K E + K + + D+ + T LQ + +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVK-NLTEEMAGLDETIAKLTK-EKKALQEAHQQTLD 1012
Query: 551 DLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALD 610
DL+ + E ++ L + I+LE QV + + E +KI +L+ KRKL+ +L+ A +
Sbjct: 1013 DLQAE----EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 611 KTEELEVSNGHLVKRLEKMKANRSALLSQ 639
T ++E L ++L+K + S L S+
Sbjct: 1069 STMDIENDKQQLDEKLKKKEFEMSGLQSK 1097
Score = 62.0 bits (149), Expect = 2e-09
Identities = 86/396 (21%), Positives = 165/396 (41%), Gaps = 99/396 (25%)
Query: 266 ELNELKDQIQDVEGKYMQ---GLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
E++ L+ +I+D + MQ +KE++ + E+EE+ + S A+ + ++++ +++
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 323 LKDMLLEL--------------EEQLAESRRQYEEKNKEFE------REKHAHSILQFQF 362
+ + L E E + + RR EE + E R+KHA S+ +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE--- 1206
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIR-EISDLQETIEWKDKKIGALERQKEFFDSVR 421
L ++ + L+ ++Q +K+ S ++ EI DL +E K G LE+ +
Sbjct: 1207 ------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
SE EE L +L L +E +GE S L+ K+ L + S
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRARLQTE---SGEYSRQLDE----------KDTLVSQLSR 1307
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
G ++ +QI++LK QLEE ++ H +
Sbjct: 1308 G--------------KQAFTQQIEELKRQLEE--------------EIKAKSALAHALQ- 1338
Query: 542 QRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK 600
++R DL + + EQE A L++ + + S+V+++++ E
Sbjct: 1339 ---SSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET-------------- 1381
Query: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSAL 636
A+ +TEELE + L +RL+ + + A+
Sbjct: 1382 ------DAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/388 (19%), Positives = 187/388 (48%), Gaps = 42/388 (10%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMV-SNAQLDNEKTNFMYQVDTL 323
+E+++L +QI + GK + L+++K + + + + + A+ + A L++E+ +
Sbjct: 1511 QEISDLTEQIAE-GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR----- 1564
Query: 324 KDMLLELEEQLAESRRQYEEKNKEFEREKHAH--------SILQFQFAEVKEALKQREEM 375
+ LEL + +E R+ EK++E ++ K H S L + +A++ +++M
Sbjct: 1565 --IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1622
Query: 376 LEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLK 435
++ +++ + + R ++ +++ + + Q D++RS+ +DL+E++ M++
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRN--YRNTQAILKDTQLHLDDALRSQ-EDLKEQLAMVE 1679
Query: 436 EELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVD 495
+L +EI E TL + K+ ++EL L + L++
Sbjct: 1680 RRAN----LLQAEIE---ELRATLEQT--ERSRKIAEQELLDASERVQ-LLHTQNTSLIN 1729
Query: 496 ERECLLEQIKKLKGQLE----------ERQKIGKLDN-LRSEDDVLENGTDMHVMDLQRD 544
++ L I +++G++E E+ K D + +E+ E T H+ ++++
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 545 ANRQISDLKFKLAKSEQ-EITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQR 603
+ + DL+ +L ++EQ + ++ + +LE++V + E+ +K E RK +R
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHER 1849
Query: 604 ELRSALDKTEELEVSNGHLVKRLEKMKA 631
+++ +TEE + L ++K++A
Sbjct: 1850 KVKELTYQTEEDRKNILRLQDLVDKLQA 1877
Score = 56.2 bits (134), Expect = 9e-08
Identities = 87/434 (20%), Positives = 174/434 (40%), Gaps = 48/434 (11%)
Query: 244 SRRGSGDTSISIDTEASIREIK-ELNELKDQIQDVEGKYMQGLKE----------MKDSL 292
+ R + I+ + A R+++ E +ELK I D+E + KE + + +
Sbjct: 927 TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 986
Query: 293 AEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREK 352
A ++E K L + + +D + L + + +Q ++ E+EK
Sbjct: 987 AGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1046
Query: 353 HAHSILQFQFAEVKEALKQREEMLEEI----RQLQQKQASSIREISDLQETIEWKD---- 404
L+ +++ LK +E +I +QL +K E+S LQ IE +
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106
Query: 405 ---KKIGALE-RQKEFFDSVRSER----------DDLREEVVMLKEELKKHGIILNSEIA 450
KKI L+ R +E + + +ER DL E+ + E L++ G +++I
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1166
Query: 451 TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI---KKL 507
N + + + +L + T KK D L EQI +++
Sbjct: 1167 MNKKREAEFQKM---------RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217
Query: 508 KGQLEERQKIGKL--DNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITA 565
K +LE+ + K+ D+L S + + ++ + R Q+S++K K + ++ I
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKG-NLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 566 LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
L RL+++ Y + + + +L K+ +++ + EE + L
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 626 LEKMKANRSALLSQ 639
L+ + + L Q
Sbjct: 1337 LQSSRHDCDLLREQ 1350
Score = 53.9 bits (128), Expect = 4e-07
Identities = 81/444 (18%), Positives = 183/444 (41%), Gaps = 49/444 (11%)
Query: 221 TEKGSRNMPGLSAATLASLGGTSSRRGSGD----------TSISIDTEASIREIKELNEL 270
TEK NM T L T ++R + + + +A + + E
Sbjct: 849 TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEER 908
Query: 271 KDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLEL 330
DQ+ + + +KE+ + + EE NA+L +K + LK + +L
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSELKKDIDDL 961
Query: 331 EEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSI 390
E LA + E+EKHA +VK ++ + E I +L +++ +
Sbjct: 962 ELTLA-----------KVEKEKHATE------NKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 391 REISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA 450
+ ++ ++ K+ L + K + + + E+ ++ +L++ L ++
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK 1064
Query: 451 TNGETSDTLNNVGYQGPTKMTKE--ELNALKS--TGDGTLDIRLKKLVDERECLLEQI-K 505
E++ + N Q K+ K+ E++ L+S + L ++L+K + E + +E++ +
Sbjct: 1065 LAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 506 KLKGQLEERQKIGK--------LDNLRSEDDVLENGTDMHV-MDLQRDANRQISDLKFKL 556
+++ + R K K L+ + + T + M+ +R+A Q +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 557 AKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELE 616
A + E TA +S V+ +N ++++ +L+ EK +++ E+ E +
Sbjct: 1185 ATLQHEATAATLRKKHADS-VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 617 VSNGHLVKRLEKMKANRSALLSQQ 640
+ G+L K ++ S + +++
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKE 1267
Score = 40.0 bits (92), Expect = 0.007
Identities = 38/162 (23%), Positives = 76/162 (46%), Gaps = 13/162 (8%)
Query: 258 EASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFM 317
E I +I+ E++D IQ+ + K + D+ A + E+ KK ++A L+ K N
Sbjct: 1735 ETDISQIQ--GEMEDIIQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 318 YQVDTLKDMLLELEEQLAESRRQY----EEKNKEFEREKHAHSILQFQFAEVKEALKQRE 373
V L+ L E E+ + ++ E + +E E E + Q + E + L++ E
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE---QKRNVEAVKGLRKHE 1848
Query: 374 EMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKE 415
++E+ ++ +I + DL + ++ K+ + +RQ E
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQ---AKVKSYKRQAE 1887
Score = 38.1 bits (87), Expect = 0.025
Identities = 56/324 (17%), Positives = 130/324 (40%), Gaps = 31/324 (9%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDS---LAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
+LNE++ Q+ + L+ +++ L + + A+ S L + + +
Sbjct: 1625 DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFA-----------EVKEALKQ 371
L+ + EL L ++ R + +E +L Q ++ + +
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 372 REEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
E++++E R ++K +I + + + E ++ + LER K+ + + +E
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804
Query: 432 VML-----KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L K++++K + E+ E+ N +G K ++ T +
Sbjct: 1805 EQLALKGGKKQIQKLEARVR-ELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK 1863
Query: 487 DI-RLKKLVDERECLLEQIKKLKGQLEERQKI--GKLDNLRSEDDVLENGTDMHVMDLQR 543
+I RL+ LVD+ + ++ K+ + EE+ + K ++ E + E D+
Sbjct: 1864 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADI------- 1916
Query: 544 DANRQISDLKFKLAKSEQEITALE 567
A Q++ L+ K + +I + E
Sbjct: 1917 -AESQVNKLRVKSREVHTKIISEE 1939
Score = 33.9 bits (76), Expect = 0.47
Identities = 20/116 (17%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
K++ +L+ +++++EG+ K +++ + + +K Q + ++ N + L+
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL----RLQ 1869
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
D++ +L+ ++ +RQ EE ++ +Q + E +E E + ++R
Sbjct: 1870 DLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 77.0 bits (188), Expect = 5e-14
Identities = 83/377 (22%), Positives = 173/377 (45%), Gaps = 46/377 (12%)
Query: 264 IKELNELKDQIQDVEGKYM---QGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQV 320
++E+ + KD + + Y Q + K + E+KYK + N +++ E N +
Sbjct: 795 LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 321 DTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
L L+ +L+ ++ +EK +E + + + ++KE L+ R+ L+ +
Sbjct: 855 QKFDSSLGALKTELSYKTQELQEKTREVQERLN-------EMEQLKEQLENRDSTLQTV- 906
Query: 381 QLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD--------------D 426
+++ + I E LQ+T+E + K+ +S++ ERD D
Sbjct: 907 ---EREKTLITE--KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
+E++ E LK+H +N+ + E + N+ + T TK+E D
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISE--EVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 487 DIRLKKL------VDERECLLEQIKKLKGQLEERQKIGK-LDNLRSEDDVLENGTDMHVM 539
D+ K V + E ++EQ +K+ ++E+ ++ + L+++ +E + L+ TD+
Sbjct: 1020 DLEAKNTQTLTADVKDNE-IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLK--TDLKEN 1076
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQN-VIRLESQVSRYKSAAENAEKIEDELKAEK 598
N++ L K +QEI A E+N I+ E ++SR + ++E++LK +
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR---TCDRLAEVEEKLKEKS 1133
Query: 599 RKLQRELRSALDKTEEL 615
++LQ + + L+ EE+
Sbjct: 1134 QQLQEKQQQLLNVQEEM 1150
Score = 75.1 bits (183), Expect = 2e-13
Identities = 91/407 (22%), Positives = 183/407 (44%), Gaps = 63/407 (15%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDS---LAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
E ++LK+ I+++ K+++ +E+K + L E EE + V+ ++ + E + Q++
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
+ D L +++ E Q+ K +EK + + QF KE K ++ L+ I
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEK-VNELKQF-----KEHRKAKDSALQSI--- 1567
Query: 383 QQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREE----VVMLKEEL 438
+ K + + QE I+ K+ ++R +E +++ ERD L+E V +KE
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE---ALQIERDQLKENTKEIVAKMKESQ 1624
Query: 439 KKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG--TLDIRLKKLVDE 496
+K L ++ ET + + + + KE+ K + T +IRL +++ E
Sbjct: 1625 EKEYQFL--KMTAVNETQEKMCEIEH------LKEQFETQKLNLENIETENIRLTQILHE 1676
Query: 497 RECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKL 556
+ + K + L ++ K++ D + EN + DL++ +I + K
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVER----DQLKENLRETITRDLEKQEELKIVHMHLK- 1731
Query: 557 AKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSA-------- 608
+ ++ I L V +++S + E++ D LKA+ K+Q ELR A
Sbjct: 1732 -EHQETIDKLRGIVSEKTNEISNMQKDLEHSN---DALKAQDLKIQEELRIAHMHLKEQQ 1787
Query: 609 --LDKT---------------EELEVSNGHLVKRLEKMKANRSALLS 638
+DK ++LE SN L ++++++KAN L++
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT 1834
Score = 71.2 bits (173), Expect = 3e-12
Identities = 89/403 (22%), Positives = 180/403 (44%), Gaps = 26/403 (6%)
Query: 253 ISIDTEASIR----EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
++I+ + +R E+K+ E+ Q ++ K L D LAEVEEK K+ +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAE-SRRQYEEKNKEFEREKHAHSILQFQFAEVKE 367
+ N ++ ++ + E+E E ++ ++ E ER + A L + EVK
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK-LNENYEEVKS 1197
Query: 368 ALKQREEMLEEIRQLQQKQASSIR------EISDLQETIEWKDKKIGALERQKEFFDSVR 421
K+R ++L+E+++ + + +R E + LQ E K I E Q E D +R
Sbjct: 1198 ITKER-KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ-ETIDELR 1255
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
+ +++ ++L+K L EI E + L NV T+ T EL L
Sbjct: 1256 RSVSEKTAQIIN-TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
L ++ ER L E+ ++ + +++ K + DNL++ + LE D L
Sbjct: 1315 STTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK--ERDNLKTIKEALEVKHD----QL 1368
Query: 542 QRDANRQISDLKFKLAKSEQEITALEQN--VIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+ ++ ++ +K EQ + E++ ++ S++ ++K +IE E+ +
Sbjct: 1369 KEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 600 KLQR---ELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+LQ E++S + ++L+ L +++K N ++++
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAK 1471
Score = 70.1 bits (170), Expect = 6e-12
Identities = 93/444 (20%), Positives = 185/444 (41%), Gaps = 91/444 (20%)
Query: 256 DTEASIREIK-ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKT 314
+ E +I E++ L+E + +I ++ + ++++ + E+ EK ++ + EK
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 315 NFMYQ-----------VDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFA 363
N + Q + +++ +LEL +L ES+ + + KE E K LQ +
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 364 EVKEALKQREEMLEEIRQLQQKQASSIR------------EISDLQETIEWKDKKIGALE 411
++KE K E++ ++++ Q+K+ ++ EI L+E E + + +E
Sbjct: 1608 QLKENTK---EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664
Query: 412 RQK-----------EFFDSVRSERDDLR--EEVVMLKEELKKHGI--------------- 443
+ E SV ERDDLR EE + ++ + K +
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
Query: 444 ILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLL-- 501
I++ + + ET D L + ++ T E N K ++ + L + E +
Sbjct: 1725 IVHMHLKEHQETIDKLRGI----VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 502 -------EQIKKLKGQLEER-------QKIGKLDNLRSEDDVLENGTDMH-VMDLQRDAN 546
E I KL+G + E+ QK + N + ++ + E + H ++ L++D N
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840
Query: 547 -------------RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDE 593
+QI D L+K E E L Q + ++ +N ++E+
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900
Query: 594 LKAEKRKLQRELRSALDKTEELEV 617
LK E+ +L+ L+ K +LE+
Sbjct: 1901 LKLERDQLKESLQET--KARDLEI 1922
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/419 (20%), Positives = 182/419 (43%), Gaps = 70/419 (16%)
Query: 258 EASIREIKELNELKDQIQDV----EGKYMQGLKEMKDSLAEVEEKYKKA--MVSNAQLDN 311
+ S EIK L + +D ++ + E K+ Q + ++++LA+++E K ++ + DN
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDN 1397
Query: 312 EKTNFMYQVDTLKDM----------LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQ 361
E T + +++ K +L L ++L ES + + KE + + +LQ +
Sbjct: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 362 FAEVKEALKQ----REEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFF 417
++KE +K+ E EE++ I++L+ + K+ +I +++Q E
Sbjct: 1458 SDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI 1517
Query: 418 DSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA 477
+ D L+ ++ + E+ ++ I SE+ + +N + K KE A
Sbjct: 1518 N------DKLQNKIQEIYEKEEQFNIKQISEV------QEKVNEL------KQFKEHRKA 1559
Query: 478 LKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMH 537
K + +++ ++ +L + + E+I+ + + EE +++ + L+ E D L+ T
Sbjct: 1560 -KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA--LQIERDQLKENTKEI 1616
Query: 538 VMDLQRDANRQISDLKFKLAKSEQE------------------ITALEQNVIRLES---- 575
V ++ ++ LK QE + +E IRL
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676
Query: 576 ---QVSRYKSAAENAEKIEDELKAEKRKLQRELRSA----LDKTEELEVSNGHLVKRLE 627
++ ++ +E+ LK E+ +L+ LR L+K EEL++ + HL + E
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Score = 63.9 bits (154), Expect = 4e-10
Identities = 81/394 (20%), Positives = 175/394 (44%), Gaps = 27/394 (6%)
Query: 252 SISIDTEASIREIKELNELKDQIQDVEGKYMQGLKE---MKDSLAEVEEKYKKAMVSNAQ 308
+I +D S+ I++ ++K + D E + +E ++ E++EK K+ + Q
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQF-AEVKE 367
++N+ + Q++ K M ++LE++L + + + + + + + ++ +
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724
Query: 368 ALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDL 427
K+ + +EE L++ + + E+ L +E K+I + + E + SE+D L
Sbjct: 725 LQKELNKEVEENEALRE-EVILLSELKSLPSEVERLRKEI---QDKSEELHIITSEKDKL 780
Query: 428 REEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLD 487
EVV +E + G++ EI G+T D L Q K T +E K T +
Sbjct: 781 FSEVV--HKESRVQGLL--EEI---GKTKDDLATT--QSNYKSTDQEFQNFK-TLHMDFE 830
Query: 488 IRLKKLVDERECLLEQIKKLKGQLEERQKI-GKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
+ K +++E E + ++I L +E QK L L++E ++Q N
Sbjct: 831 QKYKMVLEENERMNQEIVNLS---KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRE-- 604
++ LK +L + + +E+ + ++ + + + +D+LK + LQ E
Sbjct: 888 -EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
Query: 605 -LRSALDKTEELEV-SNGHLVKRLEKMKANRSAL 636
L+S + T + + + L LE +K ++ +
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/423 (19%), Positives = 181/423 (42%), Gaps = 51/423 (12%)
Query: 256 DTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTN 315
+ + I+E +E+ +++ +Q + + KE+ + E +EK + + A NE
Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV--NETQE 1641
Query: 316 FMYQVDTLKDML--------------LELEEQLAESRRQYEEKNKEFEREKHAHSILQFQ 361
M +++ LK+ + L + L E+ + KE + + L+ +
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 362 FAEVKEALKQRE----EMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFF 417
++KE L++ E EE++ + I L+ + K +I +++ E
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 418 -DSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV--GYQGPTKMTKEE 474
D+++++ ++EE+ + LK+ ++ E +D L+N+ + +E+
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK 1821
Query: 475 LNALKSTGDGTLDIR-----LKKLVDERECLLEQIK------------------KLKGQL 511
+ LK+ + ++ +K V E E L +QIK KL L
Sbjct: 1822 IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL 1881
Query: 512 EERQKIGK-LDNLRSEDDVLENGTDMHVMDLQRDANRQIS---DLKFKLAKSEQEITALE 567
EE + + K DNLR ++ L+ D LQ R + +LK S++ ++
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 568 QNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLE 627
+ ++ + + ++ +K +DEL+ + ++LQ++ L E++ +S+ + +E
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH-KKINEME 2000
Query: 628 KMK 630
++K
Sbjct: 2001 QLK 2003
Score = 50.1 bits (118), Expect = 6e-06
Identities = 112/542 (20%), Positives = 218/542 (40%), Gaps = 79/542 (14%)
Query: 129 TNGYDGELYGSQSLNRRSGRPSCLY-------SAARPS---GSYRASVLDEGSFGGTRRG 178
T G YG +N+RS R ++ PS GS + S L+ G+ R
Sbjct: 183 TKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERA 242
Query: 179 STSGSRAPSEYSG-HLNSS----SRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSA 233
+ +G+ G ++N S + + S + + R K T ++ G +
Sbjct: 243 AQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSK-LTRILQNSLGGNAK 301
Query: 234 A-------------TLASLGGTSSRRGSGDT----SISIDTEASIREIKELNELKDQIQD 276
TL +L S+ + +T +S D R KE+ +LK Q+++
Sbjct: 302 TRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE 361
Query: 277 VEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAE 336
V + E KD LA++ E +K ++ Q NEK + ++ L +E A+
Sbjct: 362 VSLETRAQAME-KDQLAQLLE--EKDLLQKVQ--NEKIENLTRMLVTSSSLTLQQELKAK 416
Query: 337 SRRQYEEKNKEFEREKHAHSILQFQFAE--VKEALKQREEMLEEIRQLQQKQASSIREIS 394
+R+ + + K+++ QF + K +L EI + ++
Sbjct: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTL 476
Query: 395 DLQETIEWKD-KKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNG 453
D IEW K+ E + +S+R++ D+L + L+ E ++ + L
Sbjct: 477 DTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLK------- 529
Query: 454 ETSDTLNNVGYQGPTKMTKE-----ELNALKS------TGDGTLDIRLKKLVDERECLLE 502
E +D + TK +E E++ LK+ + L+ L V+ +
Sbjct: 530 EKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKED 589
Query: 503 QIKKLKGQLEERQKIGKLDNLRS---------EDDVLENGTDMHVMDLQRDANRQISDLK 553
QIKKL+ ++ + KL+N++ ED T + DA R+ + L+
Sbjct: 590 QIKKLQEYIDSQ----KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLR 645
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
+ + ++++ L ++E+ + Y+S E +K++ + L++EL+SA ++
Sbjct: 646 SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD-------LEKELQSAFNEIT 698
Query: 614 EL 615
+L
Sbjct: 699 KL 700
Score = 43.5 bits (101), Expect = 6e-04
Identities = 79/358 (22%), Positives = 154/358 (43%), Gaps = 77/358 (21%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
K++NE + ++ ++E Q K++KD + K + ++ AQ +E M V +
Sbjct: 1837 KDVNETQKKVSEME----QLKKQIKDQSLTLS-KLEIENLNLAQKLHENLEEMKSVMKER 1891
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 384
D L +EE L R Q +E +E + L+ Q E+K A +E E + +L++
Sbjct: 1892 DNLRRVEETLKLERDQLKESLQETKARD-----LEIQ-QELKTARMLSKEHKETVDKLRE 1945
Query: 385 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 444
K + +ISD+Q+ ++ +D+L++++ +EL+K +
Sbjct: 1946 KISEKTIQISDIQKDLD--------------------KSKDELQKKI----QELQKKELQ 1981
Query: 445 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI 504
L + + M+ +++N ++ +LKK + + ++ +
Sbjct: 1982 L----------------LRVKEDVNMSHKKINEME---------QLKKQFEAQNLSMQSV 2016
Query: 505 --------KKLKGQLEERQKIGK-LDNLRSEDDVLENGTDMHVMDLQ----RD-ANRQIS 550
KKL LEE + + K D LR + L+ D + L+ RD N Q+
Sbjct: 2017 RMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVK 2076
Query: 551 DLKFKLAKSEQEIT-ALEQNVIRLESQVSRYKSAAENAEKIED-ELKAEKR-KLQREL 605
K L+ +Q +T +L + R++ + RY ++ E + L EK + Q+EL
Sbjct: 2077 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKEL 2134
Score = 38.9 bits (89), Expect = 0.015
Identities = 62/296 (20%), Positives = 121/296 (40%), Gaps = 21/296 (7%)
Query: 350 REKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQ---------ETI 400
+E+ SI +F+ + E KQ+E +L +I+ LQQ RE+ DL+ E I
Sbjct: 2184 KEEQHESINKFEMDFIDEVEKQKE-LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 401 --EWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDT 458
++ + + +++ + + S R E EE + + +++K L + I +
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEK----LKNGIQKENDRICQ 2298
Query: 459 LNNVGYQGPTKMTKE--ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQK 516
+NN + E E +T + LK L ++ E L + + LK L +
Sbjct: 2299 VNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ 2358
Query: 517 IGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQ 576
+ V T + + R+ + + K E +I +++ +
Sbjct: 2359 VNPTTQDNKNPHVTSRATQLTTEKI-RELENSLHEAKESAMHKESKIIKMQKELEVTNDI 2417
Query: 577 VSRYKSAAENAEKIEDELKAEKRKLQRELR-SALDKTEELEVSNGHLVK-RLEKMK 630
+++ ++ + K ++ K + LQ ++ A EE+E LVK LEKMK
Sbjct: 2418 IAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMK 2473
Score = 34.3 bits (77), Expect = 0.36
Identities = 36/153 (23%), Positives = 66/153 (43%), Gaps = 17/153 (11%)
Query: 256 DTEASIREIKELNELKDQ-------IQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
D S ++I E+ +LK Q +Q V Q K++ +SL E+ K+ +
Sbjct: 1988 DVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE----RDE 2043
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYE---EKNKEFEREKHAHSILQFQFAEV 365
L K + + D + L E +A R+ ++ EK + ++H L+ + + +
Sbjct: 2044 LRRIKESLKMERD---QFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI 2100
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQE 398
KE LK+ EM + L + +EI +E
Sbjct: 2101 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 75.9 bits (185), Expect = 1e-13
Identities = 94/457 (20%), Positives = 195/457 (42%), Gaps = 76/457 (16%)
Query: 254 SIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEK 313
++ TE E+K++ + + ++ K Q +E+ A+ EE KKA A++ K
Sbjct: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
Query: 314 TNFMYQVDT----LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEAL 369
+ + DT L+ L L Q ++S++ E + ++ +ILQ + ++ L
Sbjct: 473 QE-LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 531
Query: 370 KQREEML----EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQ----KEFFDSVR 421
+++E ML ++I+ + +++ + EI DL++ ++ K++K+ L+++ +E
Sbjct: 532 EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 591
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV----------------GYQ 465
+ L+E V L+ + L + E T+ + Y+
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 651
Query: 466 GPTKMTKEELNALK---STGDGTL-----------------DIRLKKLVDERECLLEQIK 505
K KE+++ L+ S + +L D RLK L E E+
Sbjct: 652 KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 711
Query: 506 KLKGQLEERQKIG------------------KLDNLRSEDDVLENGTDMHVMDLQRDANR 547
K++ QL++ + ++ + E + D ++++ ++
Sbjct: 712 KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD-RLLEILKEVEN 770
Query: 548 QISDLKFKLAKSEQEITALEQNVIRL--ESQVSRYKSA--AENAEKIEDELKAEKRKLQR 603
+ +D K+A+ E+++ + V L + QV + KSA E A + ED L ++LQ
Sbjct: 771 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
Query: 604 ELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
LR D+ EELE ++ ++ A R +L+Q+
Sbjct: 831 SLRKKDDRIEELE----EALRESVQITAEREMVLAQE 863
Score = 71.2 bits (173), Expect = 3e-12
Identities = 96/397 (24%), Positives = 179/397 (45%), Gaps = 55/397 (13%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK-----KAMVSNAQLDNEKTNFMYQV 320
E+++LKD + E K K++++ ++ +K K K V + Q D T+
Sbjct: 558 EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD----- 612
Query: 321 DTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
L LEE LAE R E ++ +R++ Q + K+ LK +E + ++
Sbjct: 613 ----TALTTLEEALAEKERTIERLKEQRDRDEREK---QEEIDNYKKDLKDLKEKVSLLQ 665
Query: 381 -QLQQKQASSI---REISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKE 436
L +K+AS + S L + KD ++ LE E +EE + ++
Sbjct: 666 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALE----------QKKEECLKMES 715
Query: 437 ELKK-HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVD 495
+LKK H L E + E SD + ++ + K+E + ++ D L+I LK++ +
Sbjct: 716 QLKKAHEAAL--EARASPEMSDRIQHL--EREITRYKDESSKAQAEVDRLLEI-LKEVEN 770
Query: 496 ERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR------DANRQI 549
E+ ++I +L+ Q++++ K K+ NL+ ++ V + + + + +R D+++Q+
Sbjct: 771 EKNDKDKKIAELERQVKDQNK--KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 550 SDLKFKLAKSEQEITALE-------QNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQ 602
D L K + I LE Q E +++ +SA NAEK +EL K++
Sbjct: 829 QD---SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 885
Query: 603 RELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+EL S K + S L ++A R L +
Sbjct: 886 QELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE 922
Score = 62.0 bits (149), Expect = 2e-09
Identities = 127/613 (20%), Positives = 246/613 (40%), Gaps = 113/613 (18%)
Query: 30 AREAEARLAAKRAARAEAREIRMK-ELERQQKEIYQVQKKYYGLDTKWGDIEQWMED-SE 87
++EA+ K+AA +A ++K EL R+ E+ +Q K L ++ D +Q +E E
Sbjct: 449 SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
Query: 88 RYSRRSRRNTSASDE--------DERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYG- 138
+ + +R E +E+ ++ ++ + + Q E G A GE++
Sbjct: 509 SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA------GEIHDL 562
Query: 139 -------SQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSG 191
+ +N + L R +S+ + + +T+ A +
Sbjct: 563 KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVK--SLQADTTNTDTALTTLEE 620
Query: 192 HLNSSSRASSRASSARASPVVEERPE--------KDFTEKGSRNMPGLSAATLASLGGTS 243
L R R R E++ E KD EK S LS + L
Sbjct: 621 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
Query: 244 SRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLA--EVEEKYKK 301
+ + D+ EI L + K++ +E + + + ++ A E+ ++ +
Sbjct: 681 HASSLASSGLKKDSRLKTLEIA-LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 739
Query: 302 AMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQ-------LAESRRQYEEKNKEFEREKHA 354
+ +E + +VD L ++L E+E + +AE RQ +++NK+ KH
Sbjct: 740 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799
Query: 355 HSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQK 414
+ + + A++ E ++RE+ L + Q LQ+++ KD +I LE
Sbjct: 800 EQVEKKKSAQMLEEARRREDNLNDSSQ-------------QLQDSLRKKDDRIEELEEAL 846
Query: 415 EFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEE 474
+ +ER E+V+ +EE + TN E K +E
Sbjct: 847 RESVQITAER-----EMVLAQEESAR----------TNAE--------------KQVEEL 877
Query: 475 LNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSE-----DDV 529
L A ++K+ E E + ++ + L E++ L NLR+E ++V
Sbjct: 878 LMA------------MEKVKQELESMKAKLSSTQQSLAEKET--HLTNLRAERRKHLEEV 923
Query: 530 LENGTDMHVMDL-QRDANRQISDLKFKLAKSEQEITALEQNVIRLESQV-----SRYKSA 583
LE + + + ++DAN + +L K+++E+ AL++ RL Q+ +R K
Sbjct: 924 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLM 983
Query: 584 AENAEKIEDELKA 596
A+N E +D K+
Sbjct: 984 ADNYE--DDHFKS 994
Score = 61.2 bits (147), Expect = 3e-09
Identities = 88/412 (21%), Positives = 177/412 (42%), Gaps = 80/412 (19%)
Query: 257 TEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 316
TE + L E + + +E Q KE E+ +++ A D+ KT
Sbjct: 326 TEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAP------DSAKTKA 379
Query: 317 MYQVDTLKDM--------LLELEEQL----AESRRQYEEKNKEFEREK--HAHS-ILQFQ 361
+ V +KD L +LEE++ + EE+ +E ++ + +HS ++ +
Sbjct: 380 LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK 439
Query: 362 FAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVR 421
++KE L +E EE L++K A EI +++ + KD ++ AL+ + E ++
Sbjct: 440 VEQLKEELSSKEAQWEE---LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLE---TLT 493
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
++ D ++ + +LKE L KE+ A+ T
Sbjct: 494 NQFSDSKQHIEVLKESL-------------------------------TAKEQRAAILQT 522
Query: 482 GDGTLDIRLKKLVDERECLL-EQIKKLKGQLEER-QKIGKLDNLRSEDDVLENGTDM--- 536
L +RL +E+E +L ++ K+++ EE+ + G++ +L+ DV E ++
Sbjct: 523 EVDALRLRL----EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 578
Query: 537 ---HVMDLQRDANRQISDLKFKL-------AKSEQEITALEQNVIRLESQVSRYKSAAEN 586
++ + RD +Q+S LK ++ ++ +T LE+ + E + R K E
Sbjct: 579 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK---EQ 635
Query: 587 AEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLS 638
++ E E + E +++L+ +K L+ L +K + S+L S
Sbjct: 636 RDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 687
Score = 59.7 bits (143), Expect = 8e-09
Identities = 78/349 (22%), Positives = 130/349 (37%), Gaps = 47/349 (13%)
Query: 293 AEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK------DMLLELEEQLAESRRQYEEKNK 346
AE E + K+ + L+ + Q TL LLE+ + S + EE ++
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 347 EFER----EKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEW 402
R E H H + + KE REEM + A + LQ IE
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF-----ENAPDSAKTKALQTVIEM 386
Query: 403 KDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV 462
KD KI ++ER DL EE+ MLK N ++T +
Sbjct: 387 KDSKISSMERGLR----------DLEEEIQMLKS---------NGALSTEEREEEMKQME 427
Query: 463 GYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDN 522
Y+ +K K ++ +LK+ + +E E++KK L+ K +
Sbjct: 428 VYRSHSKFMKNKVE------------QLKEELSSKEAQWEELKKKAAGLQAEIGQVKQEL 475
Query: 523 LRSEDDVLENGTDMHVMDLQ-RDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYK 581
R + ++L T + + Q D+ + I LK L EQ L+ V L ++ +
Sbjct: 476 SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
Query: 582 SAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK 630
+ K ++ EK E+ D + E L K++E ++
Sbjct: 536 TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 584
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/443 (20%), Positives = 187/443 (42%), Gaps = 51/443 (11%)
Query: 212 VEERPEKDFTEKGSRNMPGLSAATLA-SLGGTSSRRGSGDTSISIDTEASIREIKELNEL 270
+EE E+ E+ SR + L+ L S R + S E + + E +L
Sbjct: 1118 IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKL 1177
Query: 271 KDQIQDV----EGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD----- 321
+ +++ E K+ DS+AE+ E+ +L+ EK+ + D
Sbjct: 1178 RRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSN 1237
Query: 322 ---------TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
L+ M LE+Q++E + + EE+ + + LQ + E L ++
Sbjct: 1238 AEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Query: 373 EEMLEEIRQLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
+ ++ ++ + +Q I E+ L+E + K+ AL+ + D +R + ++ +E
Sbjct: 1298 DALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
L+ L K NSE+A TK E +A++ T + L+ K
Sbjct: 1358 AELQRALSK----ANSEVA-----------------QWRTKYETDAIQRTEE--LEEAKK 1394
Query: 492 KLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE----NGTDMHVMDLQRDANR 547
KL + E ++ + + +K + ED +L+ N + QR+ ++
Sbjct: 1395 KLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDK 1454
Query: 548 QISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRS 607
+S+ K K +++ E+ A ++ L +++ + K+ E + + L+ E + LQ+E+
Sbjct: 1455 VLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS- 1513
Query: 608 ALDKTEELEVSNGHLVKRLEKMK 630
D TE++ G + LEK+K
Sbjct: 1514 --DLTEQI-AEGGKQIHELEKIK 1533
Score = 68.9 bits (167), Expect = 1e-11
Identities = 92/424 (21%), Positives = 189/424 (44%), Gaps = 41/424 (9%)
Query: 234 ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLA 293
A ASL T R + + +D E S L++ + V ++ Q +E + L
Sbjct: 1412 AKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELE 1471
Query: 294 EVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKH 353
+++ + ++ N + Q++TL+ L++++++ Q E K+ +
Sbjct: 1472 ASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK 1531
Query: 354 AHSILQFQFAEVKEALKQREEMLE-EIRQLQQKQASSIREISDLQETIEWKDKKIGALER 412
++ + E++ AL++ E LE E ++ + Q + S++ I KD++I L+R
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1591
Query: 413 ---------QKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVG 463
Q +RS D LR + M + +L + I LN N +++L N
Sbjct: 1592 NHTRVVETMQSTLDAEIRSRNDALRVKKKM-EGDLNEMEIQLNH---ANRLAAESLRN-- 1645
Query: 464 YQGPTKMTKEELNALKSTGDGTLDIRLKKLVDEREC--LLEQIKKLKGQLEERQKIGKLD 521
Y+ + KE L G D++ + + ER L +I++L LE+ ++ K+
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKI- 1704
Query: 522 NLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIR-LESQVSRY 580
+E ++L+ + ++ Q N + + K KL ++ + + VI+ + +
Sbjct: 1705 ---AEQELLDASERVQLLHTQ---NTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKA 1758
Query: 581 KSAAENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNGHLVKRLE 627
K A +A + +ELK E K+ L+ ++L+ LD+ E+L + G K+++
Sbjct: 1759 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQ 1816
Query: 628 KMKA 631
K++A
Sbjct: 1817 KLEA 1820
Score = 66.2 bits (160), Expect = 9e-11
Identities = 89/408 (21%), Positives = 173/408 (42%), Gaps = 67/408 (16%)
Query: 262 REIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKY---------------KKAMVSN 306
++I EL ++K Q++ + + L+E + SL E K +K +
Sbjct: 1524 KQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1583
Query: 307 AQLDNEKTNFMYQVDTLKDML--------------LELEEQLAESRRQYEEKNK----EF 348
++D K N V+T++ L ++E L E Q N+
Sbjct: 1584 EEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESL 1643
Query: 349 EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIG 408
++ IL+ + +AL+ +E++ E++ ++++ EI +L T+E ++
Sbjct: 1644 RNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRK 1703
Query: 409 ALERQKEFFDSVRSERDDL----REEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGY 464
E+ E D+ SER L ++ K++L+ L SE+ + S
Sbjct: 1704 IAEQ--ELLDA--SERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAK 1759
Query: 465 QGPTK--MTKEELNALKSTG------DGTLDIRLKKL---VDERECLL-----EQIKKLK 508
+ T M EEL + T L+ +K L +DE E L +QI+KL+
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819
Query: 509 GQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQ 568
++ E + G+++N + + G H R++ +L ++ + + + L+
Sbjct: 1820 ARVRELE--GEVENEQKRNAEAVKGLRKH--------ERRVKELTYQTEEDRKNVLRLQD 1869
Query: 569 NVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELE 616
V +L+++V YK AE AE+ + ++ RKLQ EL A ++ + E
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAE 1917
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/405 (20%), Positives = 186/405 (45%), Gaps = 52/405 (12%)
Query: 265 KELNELKDQIQDVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNAQLDNEK-------- 313
K +L+ Q+ D+EG Q K +++ + ++E K A S ++N+K
Sbjct: 1025 KAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLE 1084
Query: 314 ------TNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKE 367
+N + +++ + + ++L++++ E + + EE +E E E+ + + + Q +++
Sbjct: 1085 KKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR 1144
Query: 368 ALKQREEMLEEIR-------QLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDS 419
L++ E LEE +L +K+ + +++ DL+E + + AL +K+ DS
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL--RKKHADS 1202
Query: 420 VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 479
+ +E + + + +K++L+K SE+ ET D +N K E++ +
Sbjct: 1203 M-AELGEQIDNLQRVKQKLEKE----KSELKM--ETDDLSSNAEAISKAKGNLEKM--CR 1253
Query: 480 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 539
S D +++ K+ +E++ L+ + + +L+ + G+ E D L + +
Sbjct: 1254 SLEDQVSELKTKE--EEQQRLINDLTAQRARLQT--EAGEYSRQLDEKDALVS----QLS 1305
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
++ + +QI +LK +L + + AL + + E ++ + EL+
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1365
Query: 600 KLQRELRS--------ALDKTEELEVSNGHLVKRLEKMKANRSAL 636
K E+ A+ +TEELE + L +RL++ + + A+
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAV 1410
Score = 63.9 bits (154), Expect = 4e-10
Identities = 77/399 (19%), Positives = 183/399 (45%), Gaps = 37/399 (9%)
Query: 254 SIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEK 313
S+D ++R +E L+ +I D+ + +G K++ + ++ ++ A L+ +
Sbjct: 1494 SLDQLETLR--RENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAE 1551
Query: 314 TNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAH--------SILQFQFAEV 365
+ ++ + + LEL + +E R+ EK++E ++ K H S L +
Sbjct: 1552 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSR 1611
Query: 366 KEALKQREEMLEEIRQLQ-------QKQASSIREISDLQETIEWKDKKIGALERQKEFFD 418
+AL+ +++M ++ +++ + A S+R + Q ++ E Q D
Sbjct: 1612 NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILK---------ETQLHLDD 1662
Query: 419 SVRSERDDLREEVVMLKEELKKHGIILNSEI----ATNGETSDTLNNVGYQGPTKMTKEE 474
++R + +DL+E++ +++ +L +EI AT +T + + + +
Sbjct: 1663 ALRGQ-EDLKEQLAIVERRAN----LLQAEIEELWATLEQTERSRKIAEQELLDASERVQ 1717
Query: 475 LNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDN-LRSEDDVLENG 533
L ++T +L+ V + + +E++ + EE+ K D + +E+ E
Sbjct: 1718 LLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQD 1777
Query: 534 TDMHVMDLQRDANRQISDLKFKLAKSEQ-EITALEQNVIRLESQVSRYKSAAENAEKIED 592
T H+ ++++ + + DL+ +L ++EQ + ++ + +LE++V + EN +K
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA 1837
Query: 593 ELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
E RK +R ++ +TEE + L ++K++A
Sbjct: 1838 EAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQA 1876
Score = 62.8 bits (151), Expect = 1e-09
Identities = 65/273 (23%), Positives = 123/273 (45%), Gaps = 23/273 (8%)
Query: 367 EALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD 426
E K+ M EE ++ + + A S + +L+E K + L+ + + V+SE D
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEE------KMVTLLKEKNDLQLQVQSEADS 900
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L + E+L K+ I L ++I E ++ + + K K E +
Sbjct: 901 LADAEERC-EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE------- 952
Query: 487 DIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
LKK +D+ E L +++K K E + K + + D+ + LQ
Sbjct: 953 ---LKKDIDDLELTLAKVEKEKHATENKVK-NLTEEMAGLDETIAK-LSKEKKALQETHQ 1007
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELR 606
+ + DL+ + E ++ L + +LE QV + + E +K+ +L+ KRKL+ +L+
Sbjct: 1008 QTLDDLQAE----EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1063
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
A + T ++E L ++LEK + S L+S+
Sbjct: 1064 LAQESTMDMENDKQQLDEKLEKKEFEISNLISK 1096
Score = 59.7 bits (143), Expect = 8e-09
Identities = 78/409 (19%), Positives = 177/409 (43%), Gaps = 46/409 (11%)
Query: 258 EASIREIKELNELKDQIQ-------DVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNA 307
E + +KE N+L+ Q+Q D E + Q +K +++ + EV E+ ++ NA
Sbjct: 878 EKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA 937
Query: 308 QLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKE 367
+L +K + LK + +LE LA + E+EKHA +VK
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDLELTLA-----------KVEKEKHATE------NKVKN 980
Query: 368 ALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDL 427
++ + E I +L +++ + + ++ ++ K+ L + K + + +
Sbjct: 981 LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040
Query: 428 REEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELN----ALKSTGD 483
E+ L+ +L++ L ++ E++ + N Q K+ K+E K +
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE 1100
Query: 484 GTLDIRLKKLVDERECLLEQI-KKLKGQLEERQKIGK--LDNLRSEDDVLE-----NGTD 535
++I+L+K + E + +E++ ++++ + R K K D R +++ E G
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Query: 536 MHVMDLQRDANRQISDLKFKLAKS----EQEITALEQNVIRLESQVSRYKSAAENAEKIE 591
++L + + L+ L ++ E + AL + + ++ +N ++++
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK---KHADSMAELGEQIDNLQRVK 1217
Query: 592 DELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+L+ EK +L+ E E + + G+L K ++ S L +++
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266
Score = 34.3 bits (77), Expect = 0.36
Identities = 20/116 (17%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
K++ +L+ +++++EG+ K +++ + + ++ Q + ++ N + L+
Sbjct: 1813 KQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVL----RLQ 1868
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
D++ +L+ ++ +RQ EE ++ LQ + E +E E + ++R
Sbjct: 1869 DLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLR 1924
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 74.3 bits (181), Expect = 3e-13
Identities = 93/425 (21%), Positives = 185/425 (43%), Gaps = 70/425 (16%)
Query: 259 ASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE---VEEKYKKAMVSNAQLDNEKTN 315
AS E KEL EL+D+ + + + + LK+ +D E ++ K + N L +
Sbjct: 270 ASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE 329
Query: 316 FMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA-----------HSILQFQFAE 364
F + L+D L EL E+ +++ +++ EK + E+E A + ILQ + ++
Sbjct: 330 FASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ 389
Query: 365 VKEALKQ--------REEMLEEIRQLQ---QKQASSIREISDLQETIEW-------KDKK 406
++E L Q + E+L ++ QL+ Q+ A+ + LQ +E ++ K
Sbjct: 390 LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK 449
Query: 407 I----GALERQKEFFDSVRSERDDLREEVVMLKEELKK----HGIILNSEIATNGETSDT 458
+ G E +K+ S+ ++ + KEEL++ HG L +++A+ T
Sbjct: 450 LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTT 509
Query: 459 LNNVGYQ------GPTKMTKEELNALKST--GDGTLDIRLKKLVDERECLLEQIKKLKGQ 510
LN Q G + KE+ L T L+ V++ L+Q ++ +
Sbjct: 510 LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 511 LEERQKIGKLD--------------NLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKL 556
+ E+Q+ + D +LR D L+ + ++ ++ A +I + ++
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALK---QLEALEKEKAAKLEILQQQLQV 626
Query: 557 A-----KSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDK 611
A ++ +T ++ L +V ++ E A + + E +A+ +L+ +LRS K
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 612 TEELE 616
E E
Sbjct: 687 ATEKE 691
Score = 62.0 bits (149), Expect = 2e-09
Identities = 106/531 (19%), Positives = 218/531 (41%), Gaps = 77/531 (14%)
Query: 150 SCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRAS--------- 200
S L SA R ++R V D + + R +E L SS
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242
Query: 201 -SRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEA 259
S +V EK ++K + L A T ++ S+R +++ + ++
Sbjct: 1243 EKEGESKELKRLVMAESEK--SQKLEERLRLLQAETASN----SARAAERSSALREEVQS 1296
Query: 260 SIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKY--KKAMVSNAQLDNEKTNFM 317
E ++ + ++ + +E+ L +EK+ K+ +S QL++ T +
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356
Query: 318 Y-QVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFA----EVKEALKQR 372
++ K + +L+ + A + +++ E E E+ K A L+ + E+ E + R
Sbjct: 1357 VSELLPAKHLCQQLQAEQAAAEKRHRE---ELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGAL-ERQKEFFDSVRSERDDLREEV 431
+++ E+ R QQ +A E + E + K G L E + + R L E+
Sbjct: 1414 QKVAEQERTAQQLRA----EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
+E+ + A + L V Q + T EL + + +G
Sbjct: 1470 DQAREKY------VQELAAVRADAETRLAEV--QREAQSTARELEVMTAKYEGAK----V 1517
Query: 492 KLVDERECLLEQIKKLKGQLEE-----RQKIGKLDNLRSEDDVLENGTDMHVMDL----- 541
K+++ER+ E+ +KL Q+E+ R++ +++ L + + + + L
Sbjct: 1518 KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQA 1577
Query: 542 -----QRDANR---QISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIED- 592
Q++A R Q+++L+ +L++ EQ A E +++E + Y + + +++++
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQ---AAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 593 ------------ELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
EL+AE +L EL+ A KT+E E + HL ++ ++A
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/334 (19%), Positives = 136/334 (40%), Gaps = 39/334 (11%)
Query: 340 QYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQ-------LQQKQASSIRE 392
Q K+ E+ L+ + AE ++ L +++ + ++Q L +KQA+S E
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 393 ISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATN 452
+L+E + + L + +++E+ + ++ L EE L +
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 453 GETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLE 512
+ D LN + + +K T+E L L+ L + +++CL E+ + L+G+L
Sbjct: 335 QQLQDALNEL-TEEHSKATQEWLEK-----QAQLEKELSAALQDKKCLEEKNEILQGKLS 388
Query: 513 ERQK-------------------IGKLDNLRSEDDVL-ENGTDM--HVMDLQRDANRQIS 550
+ ++ + +L+ L+ E L N T + V L+ + +Q +
Sbjct: 389 QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEA 448
Query: 551 DLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIED----ELKAEKRKLQRELR 606
L + E+E L + L+S +S A E E+ L A+ L EL
Sbjct: 449 KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT 508
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+ ++ + L ++ ++ +A + L QQ
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ 542
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/396 (19%), Positives = 162/396 (40%), Gaps = 83/396 (20%)
Query: 270 LKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ----LDNEKTNFMYQVDTLKD 325
L+ Q++ + LK+ + L EV EK + +AQ E+ + + D
Sbjct: 549 LRHQVEQLSSS----LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604
Query: 326 MLLELEEQLAES----RRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQ 381
L LE++ A ++Q + N+ + + + + Q + AE+ +++ + +E RQ
Sbjct: 605 QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ 664
Query: 382 LQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKH 441
Q + + + E+ ++ + ++ A E+++ V E+D L+E++ LKE L
Sbjct: 665 EQHEAQAQVAELE-----LQLRSEQQKATEKER-----VAQEKDQLQEQLQALKESL--- 711
Query: 442 GIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIR---LKKLVDERE 498
K+TK L K L+ + + +L E
Sbjct: 712 ---------------------------KVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 499 CLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAK 558
L+EQ K+ + +LEE ++ G+ G + + L + L+ +LA+
Sbjct: 745 SLVEQHKRERKELEE-ERAGR------------KGLEARLQQLGEAHQAETEVLRRELAE 791
Query: 559 SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDE-----------LKAEKRKLQRELRS 607
+ E +L +V+ ++ E++++ E + LK E K ++EL+
Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE 851
Query: 608 ALDKTEELEVSNGHLVKR----LEKMKANRSALLSQ 639
A +K +E + + R L ++ AN + L Q
Sbjct: 852 AKEKVAGIESHSELQISRQQNELAELHANLARALQQ 887
Score = 49.3 bits (116), Expect = 1e-05
Identities = 89/425 (20%), Positives = 180/425 (42%), Gaps = 31/425 (7%)
Query: 222 EKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKY 281
E+ + L AA + S G RG + ++ T+ R +L K ++E +
Sbjct: 975 EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034
Query: 282 MQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQY 341
L E + A ++E A+ D E + ++ L+ ++ E+L ++ +Q
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGKDQE----LAKLRGLEAAQIKELEELRQTVKQL 1090
Query: 342 EEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIE 401
+E+ + E+E + S Q + A E + E L E+S L++ +
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA-------------EVSKLEQQCQ 1137
Query: 402 WKDKKIGALERQKEFFDSVRSERDDLREEVV-MLKEELKKHGIILNSEIATNGETSDTLN 460
+ ++ +LER E + R+ERD E + L+E+ ++ G ++ + E +
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197
Query: 461 NVGYQGPTKMTKEELNALKSTGDGTLDIR---LKKLVDERECLLEQIKKLKGQLEERQKI 517
V Q +K ++E A + G + + + L +E L Q+ + +G+ +E +++
Sbjct: 1198 KV--QDHSK-AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
Query: 518 GKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQV 577
++ +S+ LE + ++ + +N + + + E + E R+ S+
Sbjct: 1255 VMAESEKSQK--LEE--RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310
Query: 578 SRYK--SAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSA 635
R + S AE AE++ ELKA + K ++ AL + S LV L K
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQK-EQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 636 LLSQQ 640
L ++Q
Sbjct: 1370 LQAEQ 1374
Score = 42.0 bits (97), Expect = 0.002
Identities = 71/356 (19%), Positives = 134/356 (37%), Gaps = 34/356 (9%)
Query: 285 LKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEK 344
L+ ++ L E ++ + + A E F +V E + Q+A R++ E K
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223
Query: 345 NKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKD 404
N + SIL Q E + K+ + ++ + QK +R + E
Sbjct: 1224 NSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ-----AETAS 1278
Query: 405 KKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII---LNSEIATNGETSDTLNN 461
A ER LREEV L+EE +K + L E+ + E ++ L
Sbjct: 1279 NSARAAERSSA-----------LREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ 1327
Query: 462 --VGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGK 519
+Q ++ L+ L+ T + + L + C Q ++ + R+++
Sbjct: 1328 ELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEL-- 1385
Query: 520 LDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSR 579
+ G ++ QR+ ++ L+ K+A+ E+ L Q+S
Sbjct: 1386 -----EQSKQAAGGLRAELLRAQRELG-ELIPLRQKVAEQERTAQQLRAEKASYAEQLSM 1439
Query: 580 YKSA----AENAEKIEDELKAEKRKLQRELRSALDK-TEELEVSNGHLVKRLEKMK 630
K A AE + + ++ L+ EL A +K +EL RL +++
Sbjct: 1440 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ 1495
Score = 39.3 bits (90), Expect = 0.011
Identities = 31/112 (27%), Positives = 58/112 (51%), Gaps = 8/112 (7%)
Query: 287 EMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNK 346
++ + A++ +K + A Q++ KT++ D K EL+EQL S Q +++NK
Sbjct: 1592 QLNELQAQLSQKEQAAEHYKLQMEKAKTHY----DAKKQQNQELQEQL-RSLEQLQKENK 1646
Query: 347 EF--EREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDL 396
E E E+ H LQ + KEA + + ++R L+ + A + +++ DL
Sbjct: 1647 ELRAEAERLGHE-LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 73.9 bits (180), Expect = 4e-13
Identities = 94/418 (22%), Positives = 181/418 (43%), Gaps = 70/418 (16%)
Query: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF----MYQVDT 322
+N+L+ +I +E + LK K LA+VE + ++ L+ EK+N YQ+
Sbjct: 641 INDLQGRICGLE----EDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKV 696
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
++ L + E + ++ + +KNK +E + A S EA+K+ E+ L E R L
Sbjct: 697 IQQSLEQEEAEHKATKARLADKNKIYESIEEAKS----------EAMKEMEKKLLEERTL 746
Query: 383 QQKQASSIREI----SDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEEL 438
+QK + + E S L ++ +KI L +QK+ + +D+R + +++E
Sbjct: 747 KQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN------EDVRNLTLKIEQET 800
Query: 439 KKHGIILNSEIATNGETSDTLNNVGYQ--------GPTKMTKEELNALKSTGDGTLDIRL 490
+K + N ++ + +TL Q KM E+ NA D ++
Sbjct: 801 QKRCLTQN-DLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQM 859
Query: 491 KKLVDEREC-------LLEQIKKLKGQLEERQKIGK------------LDNLRSEDDVLE 531
K+L D+ E Q+++LK + EE+ K+GK D+L ++ ++
Sbjct: 860 KELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITL 919
Query: 532 NGTDMHVM----------DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYK 581
D + DL+++ + ++K +A+ +QE+T + + LE
Sbjct: 920 TKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLT 979
Query: 582 SAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
S N ++EL + + +Q +L D+ E+S + + EK L +Q
Sbjct: 980 SDVANLANEKEELNNKLKDVQEQLSRLKDE----EISAAAIKAQFEKQLLTERTLKTQ 1033
Score = 65.9 bits (159), Expect = 1e-10
Identities = 134/691 (19%), Positives = 270/691 (39%), Gaps = 102/691 (14%)
Query: 26 LNQIAREAEARLAAKRAARAEAREIRM-------KELERQQKEIYQVQKKYYGLDTKWGD 78
L + A+E E + +++ + R++ K E Q+K ++ KK L+
Sbjct: 477 LEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKR-NLENDVNS 535
Query: 79 IEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYG 138
++ +ED ++ ++ S+ +T ++ +R + LR++ D ++
Sbjct: 536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAES-SKQIQQ 594
Query: 139 SQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSR 198
+S NR +CL A+ L + + RR T GS ++ G +
Sbjct: 595 LESNNRDLQDKNCLLETAKLKLEKEFINL-QSALESERRDRTHGSEIINDLQGRICGLEE 653
Query: 199 ASSRASSARASPVVEERP-EKDFT--EKGSRNMPGLSAATL-----------ASLGGTSS 244
A +E+R ++ FT EK NM L A T +
Sbjct: 654 DLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKA 713
Query: 245 RRGSGDTSISIDTEASIREIKELN----ELKDQIQDVEGKYMQGLK-------EMKDSLA 293
R + EA +KE+ E + Q VE ++ K ++K S
Sbjct: 714 RLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQ 773
Query: 294 EVEEKYKKAMVSNAQL-----------------DNEKTNFMYQVDTLK------------ 324
++ E K+ V N + N+ QV+TLK
Sbjct: 774 KINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNH 833
Query: 325 --DMLLELEEQLAESRR-------QYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEM 375
+M + LE+Q AE R+ Q +E + E E++ ++ + Q E+KE +++ ++
Sbjct: 834 LMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKL 893
Query: 376 LEEIRQLQQKQASSIREIS-DLQETIEWKDKKIGALERQKEFFDSVRSERD----DLREE 430
+E++Q +Q+ ++ L+ T+ D + A +E + + E+ +++E
Sbjct: 894 GKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEM 953
Query: 431 VVMLKEEL-KKHGIILNSEIATNGETSDTLNNVGYQ----GPTKMTKEELNALKSTGDGT 485
+ K+EL +K I + E TSD N + K +E+L+ LK D
Sbjct: 954 MARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLK---DEE 1010
Query: 486 LDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDA 545
+ K E++ L E+ K Q + KL + + + ++ G D V +++
Sbjct: 1011 ISAAAIKAQFEKQLLTERTLKT-------QAVNKLAEIMNRKEPVKRGNDTDVRRKEKEN 1063
Query: 546 NRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQREL 605
+ +LK + K Q++ ++ + +++Q++ + D ++ +L+ +L
Sbjct: 1064 RKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1123
Query: 606 RS---ALDKTE------ELEVSNGHLVKRLE 627
++ LD + + E +G RLE
Sbjct: 1124 QALHIGLDSSSIGSGPGDAEADDGFPESRLE 1154
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/275 (21%), Positives = 120/275 (43%), Gaps = 32/275 (11%)
Query: 377 EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKE 436
EE +++Q+K + +S+ + E ++K ++ + E E LR+ V
Sbjct: 440 EESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALR 499
Query: 437 ELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNALKSTGDGTLDIRLKKLVD 495
+L++ +L + A +D ++ K E ++N+LK + LKK
Sbjct: 500 QLEREKALLQHKNAEYQRKAD------HEADKKRNLENDVNSLKDQLED-----LKKRNQ 548
Query: 496 ERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFK 555
+ E++ +L+ QL+E + LR+E D T + Q ++++QI L+
Sbjct: 549 NSQISTEKVNQLQRQLDETNAL-----LRTESD-----TAARLRKTQAESSKQIQQLESN 598
Query: 556 LAKSEQEITALEQNVIRLESQVSRYKSAAE-------NAEKIEDELKAEKRKLQRELRSA 608
+ + LE ++LE + +SA E + +I ++L+ L+ +L++
Sbjct: 599 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNG 658
Query: 609 LDKTEELEVSNGHLVKR---LEKMKANRSALLSQQ 640
++E+ L +R LEK K+N ++ Q
Sbjct: 659 KILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQ 693
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/394 (22%), Positives = 176/394 (44%), Gaps = 51/394 (12%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVS-NAQLDNEKTNFMYQVD 321
EI + N +I+++EG ++ L+E DS K +K +L+ KT +D
Sbjct: 1102 EIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 322 ---TLKDMLLELEEQLAESRRQYEEKNKEFE------REKHAHSILQFQFAEVKEALKQR 372
T +++ + E+++ ++ +E+ + E R+KHA ++ + E E K+
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRA 1218
Query: 373 EEMLEEIRQLQQKQ----ASSIREISDLQETIEWKDKKIGAL--ERQKEFFDSVRSERDD 426
+ L++ +Q +K+ A +R + ++ +E K KK+ A E Q + D R+ R +
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAE 1277
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L ++V L+ E++ +LN G+ +V +EL ++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 487 DIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
+L++L +ER L +Q+ + ++E +Q + + H+ L N
Sbjct: 1335 STKLRQLEEERNSLQDQLDE---EMEAKQNL-----------------ERHISTL----N 1370
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELR 606
Q+SD K KL + ALE+ R + ++ E D+L+ K +LQ+EL
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
D +L+ + LV LEK + LL+++
Sbjct: 1431 ---DLVVDLD-NQRQLVSNLEKKQRKFDQLLAEE 1460
Score = 72.4 bits (176), Expect = 1e-12
Identities = 91/387 (23%), Positives = 158/387 (40%), Gaps = 75/387 (19%)
Query: 265 KELNELKDQIQDV---------EGKYMQGLKEMKDSL-AEVEEKYKKAMVSNAQLDNEKT 314
KE L+++I D+ + K + LK +S+ +E+E + KK S +L+ K
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
+ + +L+ Q+AE + Q +K +E LQ A + + + Q+
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE----------LQAALARLDDEIAQKNN 1108
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
L++IR+L+ ISDLQE ++ + E+QK DL EE+ L
Sbjct: 1109 ALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKR----------DLGEELEAL 1151
Query: 435 KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNALKSTGDGTLDIRLKKL 493
K EL+ DTL++ Q + +E E+ LK D ++
Sbjct: 1152 KTELE-----------------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 494 VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
+ R+ + +++L QLE+ ++ NL LE ++ +DL
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKA--NLDKNKQTLE---------------KENADLA 1237
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
+L Q +E +LE+QV +S + E+ EL + KLQ E+ S
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 614 ELEVSNGHLVKRLEKMKANRSALLSQQ 640
E E G +K + + + S L Q
Sbjct: 1298 EAE---GKAIKLAKDVASLSSQLQDTQ 1321
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/395 (23%), Positives = 172/395 (43%), Gaps = 82/395 (20%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q ++++ K + L++ K+ + E + K+ ++QL EK Q+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
++ E EE R + K +E E H E++ L++ E + +QL
Sbjct: 899 ETELYAEAEEM----RVRLAAKKQELEEILH----------EMEARLEEEE---DRGQQL 941
Query: 383 QQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSER--DDLREEVVMLKEELKK 440
Q ++ +++ DL+E +E ++ RQK + V +E L +E++++ ++ K
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEE-----AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996
Query: 441 HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECL 500
L+ E E L T + +EE A L KL ++ E +
Sbjct: 997 ----LSKERKLLEERISDLT-------TNLAEEEEKAK----------NLTKLKNKHESM 1035
Query: 501 LEQIK-KLKGQLEERQKIGKLDNLRSEDDVLENGTDMH--VMDLQRDANRQISDLKFKLA 557
+ +++ +LK + + RQ++ KL D +D H + DLQ QI++LK +LA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGD-----ASDFHEQIADLQ----AQIAELKMQLA 1086
Query: 558 KSEQEITA---------------------LEQNVIRLESQVSRYKSAAENAEKIEDELKA 596
K E+E+ A LE ++ L+ + ++A AEK + +L
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 597 EKRKLQRELRSALDKT---EELEVSNGHLVKRLEK 628
E L+ EL LD T +EL V L+K
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Score = 66.2 bits (160), Expect = 9e-11
Identities = 66/325 (20%), Positives = 150/325 (46%), Gaps = 42/325 (12%)
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
K + QV ++ + E++L +++ + ++ E + + HS L + ++E L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV 432
E+ E +++ + A+ +E+ ++ +E + LE +++ +++ER + ++++
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEAR------LEEEEDRGQQLQAERKKMAQQML 953
Query: 433 MLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKK 492
L+E+L++ E A + L V + K ++E+ + D + K
Sbjct: 954 DLEEQLEE-------EEAARQKLQ--LEKVTAEAKIKKLEDEILVM--------DDQNNK 996
Query: 493 LVDERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISD 551
L ER+ L E+I L L EE +K L L+++ + + IS+
Sbjct: 997 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM------------------ISE 1038
Query: 552 LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDK 611
L+ +L K E+ LE+ +LE S + + + ELK + K + EL++AL +
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 612 TEELEVSNGHLVKRLEKMKANRSAL 636
++ + +K++ +++ + S L
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDL 1123
Score = 60.1 bits (144), Expect = 6e-09
Identities = 94/433 (21%), Positives = 182/433 (42%), Gaps = 86/433 (19%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEK---YKKAMVSNAQLDNEKTNFMYQVD 321
K+L + ++ +E + KE+++ + EEK Y K + +L E + + +D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 322 TLKDMLLELEEQ-------LAESRR---QYEEKNKEFEREKHAHSILQFQFAE-VKEALK 370
+ ++ LE++ LAE + +Y ++ E E A ++EAL+
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 371 QREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD---- 426
+EE+ + L+ + + D+ + + +K ALE Q E + E +D
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 427 -----LREEVVM--LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNAL 478
LR EV M LK + ++ L + N E L ++ T++ E + AL
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 479 KSTGDGTLDIRLKKL-------VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVL- 530
+ L+ LK L + RE ++Q++KL+ Q+++ Q+ +L++ R+ D +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--ELEDARASRDEIF 1672
Query: 531 ----EN-----GTDMHVMDLQRD----------ANRQISDLKFKLAKSEQEITALEQNVI 571
EN + +M LQ D A+ + +L +LA S AL+
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 572 RLESQVS------------------RYKSAAENAEKIEDELKAEK----------RKLQR 603
RLE++++ R + A + AE++ +EL E+ ++L+R
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 604 ELRSALDKTEELE 616
+ + K E+E
Sbjct: 1793 QNKELRSKLHEME 1805
Score = 60.1 bits (144), Expect = 6e-09
Identities = 92/427 (21%), Positives = 174/427 (40%), Gaps = 85/427 (19%)
Query: 191 GHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGD 250
G +A + + + + E + + R L+AA L G D
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----D 1628
Query: 251 TSISIDTEASIRE--IKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+ D+ RE IK+L +L+ Q++D + +E++D+ A +E + A
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQ-------RELEDARASRDEIFATAK----- 1676
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 368
+NEK + +L+ L++L+E LA + R K + E+E+ A E+ +
Sbjct: 1677 -ENEK-----KAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAE--------ELASS 1720
Query: 369 LKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLR 428
L R + +E R+L+ + I+ L+E +E + + A+ D VR
Sbjct: 1721 LSGRNALQDEKRRLEAR-------IAQLEEELEEEQGNMEAMS------DRVRKATQQAE 1767
Query: 429 EEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDI 488
+ L++E+AT E S N + + +EL + +G +
Sbjct: 1768 Q---------------LSNELAT--ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 489 RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQ 548
+ K + E + Q+++ Q E R+K +L+ +D L ++ Q
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKL------------KEILLQ 1857
Query: 549 ISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSA 608
+ D + K+A+ +E + ++V + K E AE+ + A +RKLQREL A
Sbjct: 1858 VEDER-KMAEQYKE------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 609 LDKTEEL 615
+ E +
Sbjct: 1911 TESNEAM 1917
Score = 59.7 bits (143), Expect = 8e-09
Identities = 95/453 (20%), Positives = 187/453 (41%), Gaps = 90/453 (19%)
Query: 250 DTSISIDTEASIREIKE-LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+T ++ +R+++E N L+DQ+ D E + Q L+ +L N Q
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL-------------NIQ 1372
Query: 309 LDNEKT---NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV 365
L + K +F V+ L++ ++++ +QYEEK +++ + + LQ + ++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD 425
L + +++ + + Q+K + E ++ + + A R+KE +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1489
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTL-NNVGYQGPTKMTKE----------- 473
EE + KEEL++ +L +E+ + D + NV +K E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 ------------------ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQ 515
+ ALK + L R ++ ++R L Q+ + + +LE+ +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 516 K------------IGKLDNLRSEDDVLENGTDMHVMDLQ------RDANRQISDLK---- 553
K G L +L + D G + + L+ +D R++ D +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 554 --FKLAK-SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL- 609
F AK +E++ +LE ++++L+ + +AAE A K D EK +L EL S+L
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQAD---LEKEELAEELASSLS 1722
Query: 610 ------DKTEELEVSNGHLVKRLEKMKANRSAL 636
D+ LE L + LE+ + N A+
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/394 (22%), Positives = 176/394 (44%), Gaps = 51/394 (12%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVS-NAQLDNEKTNFMYQVD 321
EI + N +I+++EG ++ L+E DS K +K +L+ KT +D
Sbjct: 1109 EIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 322 ---TLKDMLLELEEQLAESRRQYEEKNKEFE------REKHAHSILQFQFAEVKEALKQR 372
T +++ + E+++ ++ +E+ + E R+KHA ++ + E E K+
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRA 1225
Query: 373 EEMLEEIRQLQQKQ----ASSIREISDLQETIEWKDKKIGAL--ERQKEFFDSVRSERDD 426
+ L++ +Q +K+ A +R + ++ +E K KK+ A E Q + D R+ R +
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAE 1284
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L ++V L+ E++ +LN G+ +V +EL ++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 487 DIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
+L++L +ER L +Q+ + ++E +Q + + H+ L N
Sbjct: 1342 STKLRQLEEERNSLQDQLDE---EMEAKQNL-----------------ERHISTL----N 1377
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELR 606
Q+SD K KL + ALE+ R + ++ E D+L+ K +LQ+EL
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
D +L+ + LV LEK + LL+++
Sbjct: 1438 ---DLVVDLD-NQRQLVSNLEKKQRKFDQLLAEE 1467
Score = 72.4 bits (176), Expect = 1e-12
Identities = 91/387 (23%), Positives = 158/387 (40%), Gaps = 75/387 (19%)
Query: 265 KELNELKDQIQDV---------EGKYMQGLKEMKDSL-AEVEEKYKKAMVSNAQLDNEKT 314
KE L+++I D+ + K + LK +S+ +E+E + KK S +L+ K
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
+ + +L+ Q+AE + Q +K +E LQ A + + + Q+
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE----------LQAALARLDDEIAQKNN 1115
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
L++IR+L+ ISDLQE ++ + E+QK DL EE+ L
Sbjct: 1116 ALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKR----------DLGEELEAL 1158
Query: 435 KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNALKSTGDGTLDIRLKKL 493
K EL+ DTL++ Q + +E E+ LK D ++
Sbjct: 1159 KTELE-----------------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 494 VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
+ R+ + +++L QLE+ ++ NL LE ++ +DL
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKA--NLDKNKQTLE---------------KENADLA 1244
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
+L Q +E +LE+QV +S + E+ EL + KLQ E+ S
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304
Query: 614 ELEVSNGHLVKRLEKMKANRSALLSQQ 640
E E G +K + + + S L Q
Sbjct: 1305 EAE---GKAIKLAKDVASLSSQLQDTQ 1328
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/395 (23%), Positives = 172/395 (43%), Gaps = 82/395 (20%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q ++++ K + L++ K+ + E + K+ ++QL EK Q+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
++ E EE R + K +E E H E++ L++ E + +QL
Sbjct: 906 ETELYAEAEEM----RVRLAAKKQELEEILH----------EMEARLEEEE---DRGQQL 948
Query: 383 QQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSER--DDLREEVVMLKEELKK 440
Q ++ +++ DL+E +E ++ RQK + V +E L +E++++ ++ K
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEE-----AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 441 HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECL 500
L+ E E L T + +EE A L KL ++ E +
Sbjct: 1004 ----LSKERKLLEERISDLT-------TNLAEEEEKAK----------NLTKLKNKHESM 1042
Query: 501 LEQIK-KLKGQLEERQKIGKLDNLRSEDDVLENGTDMH--VMDLQRDANRQISDLKFKLA 557
+ +++ +LK + + RQ++ KL D +D H + DLQ QI++LK +LA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGD-----ASDFHEQIADLQ----AQIAELKMQLA 1093
Query: 558 KSEQEITA---------------------LEQNVIRLESQVSRYKSAAENAEKIEDELKA 596
K E+E+ A LE ++ L+ + ++A AEK + +L
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 597 EKRKLQRELRSALDKT---EELEVSNGHLVKRLEK 628
E L+ EL LD T +EL V L+K
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Score = 66.2 bits (160), Expect = 9e-11
Identities = 66/325 (20%), Positives = 150/325 (46%), Gaps = 42/325 (12%)
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
K + QV ++ + E++L +++ + ++ E + + HS L + ++E L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV 432
E+ E +++ + A+ +E+ ++ +E + LE +++ +++ER + ++++
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEAR------LEEEEDRGQQLQAERKKMAQQML 960
Query: 433 MLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKK 492
L+E+L++ E A + L V + K ++E+ + D + K
Sbjct: 961 DLEEQLEE-------EEAARQKLQ--LEKVTAEAKIKKLEDEILVM--------DDQNNK 1003
Query: 493 LVDERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISD 551
L ER+ L E+I L L EE +K L L+++ + + IS+
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM------------------ISE 1045
Query: 552 LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDK 611
L+ +L K E+ LE+ +LE S + + + ELK + K + EL++AL +
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 612 TEELEVSNGHLVKRLEKMKANRSAL 636
++ + +K++ +++ + S L
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDL 1130
Score = 60.1 bits (144), Expect = 6e-09
Identities = 94/433 (21%), Positives = 182/433 (42%), Gaps = 86/433 (19%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEK---YKKAMVSNAQLDNEKTNFMYQVD 321
K+L + ++ +E + KE+++ + EEK Y K + +L E + + +D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 322 TLKDMLLELEEQ-------LAESRR---QYEEKNKEFEREKHAHSILQFQFAE-VKEALK 370
+ ++ LE++ LAE + +Y ++ E E A ++EAL+
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 371 QREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD---- 426
+EE+ + L+ + + D+ + + +K ALE Q E + E +D
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 427 -----LREEVVM--LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNAL 478
LR EV M LK + ++ L + N E L ++ T++ E + AL
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 479 KSTGDGTLDIRLKKL-------VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVL- 530
+ L+ LK L + RE ++Q++KL+ Q+++ Q+ +L++ R+ D +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--ELEDARASRDEIF 1679
Query: 531 ----EN-----GTDMHVMDLQRD----------ANRQISDLKFKLAKSEQEITALEQNVI 571
EN + +M LQ D A+ + +L +LA S AL+
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 572 RLESQVS------------------RYKSAAENAEKIEDELKAEK----------RKLQR 603
RLE++++ R + A + AE++ +EL E+ ++L+R
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 604 ELRSALDKTEELE 616
+ + K E+E
Sbjct: 1800 QNKELRSKLHEME 1812
Score = 60.1 bits (144), Expect = 6e-09
Identities = 92/427 (21%), Positives = 174/427 (40%), Gaps = 85/427 (19%)
Query: 191 GHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGD 250
G +A + + + + E + + R L+AA L G D
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----D 1635
Query: 251 TSISIDTEASIRE--IKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+ D+ RE IK+L +L+ Q++D + +E++D+ A +E + A
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQ-------RELEDARASRDEIFATAK----- 1683
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 368
+NEK + +L+ L++L+E LA + R K + E+E+ A E+ +
Sbjct: 1684 -ENEK-----KAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAE--------ELASS 1727
Query: 369 LKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLR 428
L R + +E R+L+ + I+ L+E +E + + A+ D VR
Sbjct: 1728 LSGRNALQDEKRRLEAR-------IAQLEEELEEEQGNMEAMS------DRVRKATQQAE 1774
Query: 429 EEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDI 488
+ L++E+AT E S N + + +EL + +G +
Sbjct: 1775 Q---------------LSNELAT--ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 489 RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQ 548
+ K + E + Q+++ Q E R+K +L+ +D L ++ Q
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKL------------KEILLQ 1864
Query: 549 ISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSA 608
+ D + K+A+ +E + ++V + K E AE+ + A +RKLQREL A
Sbjct: 1865 VEDER-KMAEQYKE------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 609 LDKTEEL 615
+ E +
Sbjct: 1918 TESNEAM 1924
Score = 59.7 bits (143), Expect = 8e-09
Identities = 95/453 (20%), Positives = 187/453 (41%), Gaps = 90/453 (19%)
Query: 250 DTSISIDTEASIREIKE-LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+T ++ +R+++E N L+DQ+ D E + Q L+ +L N Q
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL-------------NIQ 1379
Query: 309 LDNEKT---NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV 365
L + K +F V+ L++ ++++ +QYEEK +++ + + LQ + ++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD 425
L + +++ + + Q+K + E ++ + + A R+KE +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1496
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTL-NNVGYQGPTKMTKE----------- 473
EE + KEEL++ +L +E+ + D + NV +K E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 ------------------ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQ 515
+ ALK + L R ++ ++R L Q+ + + +LE+ +
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 516 K------------IGKLDNLRSEDDVLENGTDMHVMDLQ------RDANRQISDLK---- 553
K G L +L + D G + + L+ +D R++ D +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 554 --FKLAK-SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL- 609
F AK +E++ +LE ++++L+ + +AAE A K D EK +L EL S+L
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQAD---LEKEELAEELASSLS 1729
Query: 610 ------DKTEELEVSNGHLVKRLEKMKANRSAL 636
D+ LE L + LE+ + N A+
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/394 (22%), Positives = 176/394 (44%), Gaps = 51/394 (12%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVS-NAQLDNEKTNFMYQVD 321
EI + N +I+++EG ++ L+E DS K +K +L+ KT +D
Sbjct: 1109 EIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 322 ---TLKDMLLELEEQLAESRRQYEEKNKEFE------REKHAHSILQFQFAEVKEALKQR 372
T +++ + E+++ ++ +E+ + E R+KHA ++ + E E K+
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRA 1225
Query: 373 EEMLEEIRQLQQKQ----ASSIREISDLQETIEWKDKKIGAL--ERQKEFFDSVRSERDD 426
+ L++ +Q +K+ A +R + ++ +E K KK+ A E Q + D R+ R +
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAE 1284
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L ++V L+ E++ +LN G+ +V +EL ++ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 487 DIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
+L++L +ER L +Q+ + ++E +Q + + H+ L N
Sbjct: 1342 STKLRQLEEERNSLQDQLDE---EMEAKQNL-----------------ERHISTL----N 1377
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELR 606
Q+SD K KL + ALE+ R + ++ E D+L+ K +LQ+EL
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
D +L+ + LV LEK + LL+++
Sbjct: 1438 ---DLVVDLD-NQRQLVSNLEKKQRKFDQLLAEE 1467
Score = 72.4 bits (176), Expect = 1e-12
Identities = 91/387 (23%), Positives = 158/387 (40%), Gaps = 75/387 (19%)
Query: 265 KELNELKDQIQDV---------EGKYMQGLKEMKDSL-AEVEEKYKKAMVSNAQLDNEKT 314
KE L+++I D+ + K + LK +S+ +E+E + KK S +L+ K
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
+ + +L+ Q+AE + Q +K +E LQ A + + + Q+
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE----------LQAALARLDDEIAQKNN 1115
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
L++IR+L+ ISDLQE ++ + E+QK DL EE+ L
Sbjct: 1116 ALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKR----------DLGEELEAL 1158
Query: 435 KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNALKSTGDGTLDIRLKKL 493
K EL+ DTL++ Q + +E E+ LK D ++
Sbjct: 1159 KTELE-----------------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 494 VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
+ R+ + +++L QLE+ ++ NL LE ++ +DL
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKA--NLDKNKQTLE---------------KENADLA 1244
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
+L Q +E +LE+QV +S + E+ EL + KLQ E+ S
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304
Query: 614 ELEVSNGHLVKRLEKMKANRSALLSQQ 640
E E G +K + + + S L Q
Sbjct: 1305 EAE---GKAIKLAKDVASLSSQLQDTQ 1328
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/395 (23%), Positives = 172/395 (43%), Gaps = 82/395 (20%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q ++++ K + L++ K+ + E + K+ ++QL EK Q+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
++ E EE R + K +E E H E++ L++ E + +QL
Sbjct: 906 ETELYAEAEEM----RVRLAAKKQELEEILH----------EMEARLEEEE---DRGQQL 948
Query: 383 QQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSER--DDLREEVVMLKEELKK 440
Q ++ +++ DL+E +E ++ RQK + V +E L +E++++ ++ K
Sbjct: 949 QAERKKMAQQMLDLEEQLEEEE-----AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 441 HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECL 500
L+ E E L T + +EE A L KL ++ E +
Sbjct: 1004 ----LSKERKLLEERISDLT-------TNLAEEEEKAK----------NLTKLKNKHESM 1042
Query: 501 LEQIK-KLKGQLEERQKIGKLDNLRSEDDVLENGTDMH--VMDLQRDANRQISDLKFKLA 557
+ +++ +LK + + RQ++ KL D +D H + DLQ QI++LK +LA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGD-----ASDFHEQIADLQ----AQIAELKMQLA 1093
Query: 558 KSEQEITA---------------------LEQNVIRLESQVSRYKSAAENAEKIEDELKA 596
K E+E+ A LE ++ L+ + ++A AEK + +L
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 597 EKRKLQRELRSALDKT---EELEVSNGHLVKRLEK 628
E L+ EL LD T +EL V L+K
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Score = 66.2 bits (160), Expect = 9e-11
Identities = 66/325 (20%), Positives = 150/325 (46%), Gaps = 42/325 (12%)
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
K + QV ++ + E++L +++ + ++ E + + HS L + ++E L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV 432
E+ E +++ + A+ +E+ ++ +E + LE +++ +++ER + ++++
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEAR------LEEEEDRGQQLQAERKKMAQQML 960
Query: 433 MLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKK 492
L+E+L++ E A + L V + K ++E+ + D + K
Sbjct: 961 DLEEQLEE-------EEAARQKLQ--LEKVTAEAKIKKLEDEILVM--------DDQNNK 1003
Query: 493 LVDERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISD 551
L ER+ L E+I L L EE +K L L+++ + + IS+
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM------------------ISE 1045
Query: 552 LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDK 611
L+ +L K E+ LE+ +LE S + + + ELK + K + EL++AL +
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 612 TEELEVSNGHLVKRLEKMKANRSAL 636
++ + +K++ +++ + S L
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDL 1130
Score = 60.1 bits (144), Expect = 6e-09
Identities = 94/433 (21%), Positives = 182/433 (42%), Gaps = 86/433 (19%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEK---YKKAMVSNAQLDNEKTNFMYQVD 321
K+L + ++ +E + KE+++ + EEK Y K + +L E + + +D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 322 TLKDMLLELEEQ-------LAESRR---QYEEKNKEFEREKHAHSILQFQFAE-VKEALK 370
+ ++ LE++ LAE + +Y ++ E E A ++EAL+
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 371 QREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD---- 426
+EE+ + L+ + + D+ + + +K ALE Q E + E +D
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 427 -----LREEVVM--LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNAL 478
LR EV M LK + ++ L + N E L ++ T++ E + AL
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 479 KSTGDGTLDIRLKKL-------VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVL- 530
+ L+ LK L + RE ++Q++KL+ Q+++ Q+ +L++ R+ D +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--ELEDARASRDEIF 1679
Query: 531 ----EN-----GTDMHVMDLQRD----------ANRQISDLKFKLAKSEQEITALEQNVI 571
EN + +M LQ D A+ + +L +LA S AL+
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 572 RLESQVS------------------RYKSAAENAEKIEDELKAEK----------RKLQR 603
RLE++++ R + A + AE++ +EL E+ ++L+R
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 604 ELRSALDKTEELE 616
+ + K E+E
Sbjct: 1800 QNKELRSKLHEME 1812
Score = 60.1 bits (144), Expect = 6e-09
Identities = 92/427 (21%), Positives = 174/427 (40%), Gaps = 85/427 (19%)
Query: 191 GHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGD 250
G +A + + + + E + + R L+AA L G D
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----D 1635
Query: 251 TSISIDTEASIRE--IKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+ D+ RE IK+L +L+ Q++D + +E++D+ A +E + A
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQ-------RELEDARASRDEIFATAK----- 1683
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 368
+NEK + +L+ L++L+E LA + R K + E+E+ A E+ +
Sbjct: 1684 -ENEK-----KAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAE--------ELASS 1727
Query: 369 LKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLR 428
L R + +E R+L+ + I+ L+E +E + + A+ D VR
Sbjct: 1728 LSGRNALQDEKRRLEAR-------IAQLEEELEEEQGNMEAMS------DRVRKATQQAE 1774
Query: 429 EEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDI 488
+ L++E+AT E S N + + +EL + +G +
Sbjct: 1775 Q---------------LSNELAT--ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 489 RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQ 548
+ K + E + Q+++ Q E R+K +L+ +D L ++ Q
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKL------------KEILLQ 1864
Query: 549 ISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSA 608
+ D + K+A+ +E + ++V + K E AE+ + A +RKLQREL A
Sbjct: 1865 VEDER-KMAEQYKE------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 609 LDKTEEL 615
+ E +
Sbjct: 1918 TESNEAM 1924
Score = 59.7 bits (143), Expect = 8e-09
Identities = 95/453 (20%), Positives = 187/453 (41%), Gaps = 90/453 (19%)
Query: 250 DTSISIDTEASIREIKE-LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+T ++ +R+++E N L+DQ+ D E + Q L+ +L N Q
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL-------------NIQ 1379
Query: 309 LDNEKT---NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV 365
L + K +F V+ L++ ++++ +QYEEK +++ + + LQ + ++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD 425
L + +++ + + Q+K + E ++ + + A R+KE +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1496
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTL-NNVGYQGPTKMTKE----------- 473
EE + KEEL++ +L +E+ + D + NV +K E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 ------------------ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQ 515
+ ALK + L R ++ ++R L Q+ + + +LE+ +
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 516 K------------IGKLDNLRSEDDVLENGTDMHVMDLQ------RDANRQISDLK---- 553
K G L +L + D G + + L+ +D R++ D +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 554 --FKLAK-SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL- 609
F AK +E++ +LE ++++L+ + +AAE A K D EK +L EL S+L
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQAD---LEKEELAEELASSLS 1729
Query: 610 ------DKTEELEVSNGHLVKRLEKMKANRSAL 636
D+ LE L + LE+ + N A+
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Score = 38.1 bits (87), Expect = 0.025
Identities = 36/155 (23%), Positives = 74/155 (47%), Gaps = 22/155 (14%)
Query: 250 DTSISIDTEASIREIKELN-ELKDQIQDVEG----KYMQGLKEMKDSLAEVEEKYKK--- 301
+ S + E++ ++++ N EL+ ++ ++EG K+ + ++ +A++EE+ ++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 302 ----AMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQ-------LAESRRQYEEKNKEFER 350
A S Q D + + QV+ + M + +EQ + + +RQ EE +E +R
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 351 EKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
LQ E+ EA + E M E+ L+ K
Sbjct: 1903 INANRRKLQ---RELDEATESNEAMGREVNALKSK 1934
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 4e-13
Identities = 90/394 (22%), Positives = 176/394 (44%), Gaps = 51/394 (12%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVS-NAQLDNEKTNFMYQVD 321
EI + N +I+++EG ++ L+E DS K +K +L+ KT +D
Sbjct: 1102 EIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 322 ---TLKDMLLELEEQLAESRRQYEEKNKEFE------REKHAHSILQFQFAEVKEALKQR 372
T +++ + E+++ ++ +E+ + E R+KHA ++ + E E K+
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL--TEQLEQFKRA 1218
Query: 373 EEMLEEIRQLQQKQ----ASSIREISDLQETIEWKDKKIGAL--ERQKEFFDSVRSERDD 426
+ L++ +Q +K+ A +R + ++ +E K KK+ A E Q + D R+ R +
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA-RAE 1277
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L ++V L+ E++ +LN G+ +V +EL ++ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 487 DIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN 546
+L++L +ER L +Q+ + ++E +Q + + H+ L N
Sbjct: 1335 STKLRQLEEERNSLQDQLDE---EMEAKQNL-----------------ERHISTL----N 1370
Query: 547 RQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELR 606
Q+SD K KL + ALE+ R + ++ E D+L+ K +LQ+EL
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 607 SALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
D +L+ + LV LEK + LL+++
Sbjct: 1431 ---DLVVDLD-NQRQLVSNLEKKQRKFDQLLAEE 1460
Score = 72.4 bits (176), Expect = 1e-12
Identities = 91/387 (23%), Positives = 158/387 (40%), Gaps = 75/387 (19%)
Query: 265 KELNELKDQIQDV---------EGKYMQGLKEMKDSL-AEVEEKYKKAMVSNAQLDNEKT 314
KE L+++I D+ + K + LK +S+ +E+E + KK S +L+ K
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
+ + +L+ Q+AE + Q +K +E LQ A + + + Q+
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE----------LQAALARLDDEIAQKNN 1108
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
L++IR+L+ ISDLQE ++ + E+QK DL EE+ L
Sbjct: 1109 ALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKR----------DLGEELEAL 1151
Query: 435 KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNALKSTGDGTLDIRLKKL 493
K EL+ DTL++ Q + +E E+ LK D ++
Sbjct: 1152 KTELE-----------------DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 494 VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
+ R+ + +++L QLE+ ++ NL LE ++ +DL
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKA--NLDKNKQTLE---------------KENADLA 1237
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
+L Q +E +LE+QV +S + E+ EL + KLQ E+ S
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 614 ELEVSNGHLVKRLEKMKANRSALLSQQ 640
E E G +K + + + S L Q
Sbjct: 1298 EAE---GKAIKLAKDVASLSSQLQDTQ 1321
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/395 (23%), Positives = 172/395 (43%), Gaps = 82/395 (20%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q ++++ K + L++ K+ + E + K+ ++QL EK Q+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 323 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQL 382
++ E EE R + K +E E H E++ L++ E + +QL
Sbjct: 899 ETELYAEAEEM----RVRLAAKKQELEEILH----------EMEARLEEEE---DRGQQL 941
Query: 383 QQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSER--DDLREEVVMLKEELKK 440
Q ++ +++ DL+E +E ++ RQK + V +E L +E++++ ++ K
Sbjct: 942 QAERKKMAQQMLDLEEQLEEEE-----AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996
Query: 441 HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECL 500
L+ E E L T + +EE A L KL ++ E +
Sbjct: 997 ----LSKERKLLEERISDLT-------TNLAEEEEKAK----------NLTKLKNKHESM 1035
Query: 501 LEQIK-KLKGQLEERQKIGKLDNLRSEDDVLENGTDMH--VMDLQRDANRQISDLKFKLA 557
+ +++ +LK + + RQ++ KL D +D H + DLQ QI++LK +LA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGD-----ASDFHEQIADLQ----AQIAELKMQLA 1086
Query: 558 KSEQEITA---------------------LEQNVIRLESQVSRYKSAAENAEKIEDELKA 596
K E+E+ A LE ++ L+ + ++A AEK + +L
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 597 EKRKLQRELRSALDKT---EELEVSNGHLVKRLEK 628
E L+ EL LD T +EL V L+K
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Score = 66.2 bits (160), Expect = 9e-11
Identities = 66/325 (20%), Positives = 150/325 (46%), Gaps = 42/325 (12%)
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 372
K + QV ++ + E++L +++ + ++ E + + HS L + ++E L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV 432
E+ E +++ + A+ +E+ ++ +E + LE +++ +++ER + ++++
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEAR------LEEEEDRGQQLQAERKKMAQQML 953
Query: 433 MLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKK 492
L+E+L++ E A + L V + K ++E+ + D + K
Sbjct: 954 DLEEQLEE-------EEAARQKLQ--LEKVTAEAKIKKLEDEILVM--------DDQNNK 996
Query: 493 LVDERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISD 551
L ER+ L E+I L L EE +K L L+++ + + IS+
Sbjct: 997 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM------------------ISE 1038
Query: 552 LKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDK 611
L+ +L K E+ LE+ +LE S + + + ELK + K + EL++AL +
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 612 TEELEVSNGHLVKRLEKMKANRSAL 636
++ + +K++ +++ + S L
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDL 1123
Score = 60.1 bits (144), Expect = 6e-09
Identities = 94/433 (21%), Positives = 182/433 (42%), Gaps = 86/433 (19%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEK---YKKAMVSNAQLDNEKTNFMYQVD 321
K+L + ++ +E + KE+++ + EEK Y K + +L E + + +D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 322 TLKDMLLELEEQ-------LAESRR---QYEEKNKEFEREKHAHSILQFQFAE-VKEALK 370
+ ++ LE++ LAE + +Y ++ E E A ++EAL+
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 371 QREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD---- 426
+EE+ + L+ + + D+ + + +K ALE Q E + E +D
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 427 -----LREEVVM--LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKE-ELNAL 478
LR EV M LK + ++ L + N E L ++ T++ E + AL
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 479 KSTGDGTLDIRLKKL-------VDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVL- 530
+ L+ LK L + RE ++Q++KL+ Q+++ Q+ +L++ R+ D +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR--ELEDARASRDEIF 1672
Query: 531 ----EN-----GTDMHVMDLQRD----------ANRQISDLKFKLAKSEQEITALEQNVI 571
EN + +M LQ D A+ + +L +LA S AL+
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 572 RLESQVS------------------RYKSAAENAEKIEDELKAEK----------RKLQR 603
RLE++++ R + A + AE++ +EL E+ ++L+R
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 604 ELRSALDKTEELE 616
+ + K E+E
Sbjct: 1793 QNKELRSKLHEME 1805
Score = 60.1 bits (144), Expect = 6e-09
Identities = 92/427 (21%), Positives = 174/427 (40%), Gaps = 85/427 (19%)
Query: 191 GHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGD 250
G +A + + + + E + + R L+AA L G D
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-----D 1628
Query: 251 TSISIDTEASIRE--IKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+ D+ RE IK+L +L+ Q++D + +E++D+ A +E + A
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQ-------RELEDARASRDEIFATAK----- 1676
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 368
+NEK + +L+ L++L+E LA + R K + E+E+ A E+ +
Sbjct: 1677 -ENEK-----KAKSLEADLMQLQEDLAAAER--ARKQADLEKEELAE--------ELASS 1720
Query: 369 LKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLR 428
L R + +E R+L+ + I+ L+E +E + + A+ D VR
Sbjct: 1721 LSGRNALQDEKRRLEAR-------IAQLEEELEEEQGNMEAMS------DRVRKATQQAE 1767
Query: 429 EEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDI 488
+ L++E+AT E S N + + +EL + +G +
Sbjct: 1768 Q---------------LSNELAT--ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 489 RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQ 548
+ K + E + Q+++ Q E R+K +L+ +D L ++ Q
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKL------------KEILLQ 1857
Query: 549 ISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSA 608
+ D + K+A+ +E + ++V + K E AE+ + A +RKLQREL A
Sbjct: 1858 VEDER-KMAEQYKE------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 609 LDKTEEL 615
+ E +
Sbjct: 1911 TESNEAM 1917
Score = 59.7 bits (143), Expect = 8e-09
Identities = 95/453 (20%), Positives = 187/453 (41%), Gaps = 90/453 (19%)
Query: 250 DTSISIDTEASIREIKE-LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
+T ++ +R+++E N L+DQ+ D E + Q L+ +L N Q
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQL-DEEMEAKQNLERHISTL-------------NIQ 1372
Query: 309 LDNEKT---NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV 365
L + K +F V+ L++ ++++ +QYEEK +++ + + LQ + ++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD 425
L + +++ + + Q+K + E ++ + + A R+KE +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1489
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTL-NNVGYQGPTKMTKE----------- 473
EE + KEEL++ +L +E+ + D + NV +K E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 ------------------ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQ 515
+ ALK + L R ++ ++R L Q+ + + +LE+ +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 516 K------------IGKLDNLRSEDDVLENGTDMHVMDLQ------RDANRQISDLK---- 553
K G L +L + D G + + L+ +D R++ D +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 554 --FKLAK-SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL- 609
F AK +E++ +LE ++++L+ + +AAE A K D EK +L EL S+L
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDL----AAAERARKQAD---LEKEELAEELASSLS 1722
Query: 610 ------DKTEELEVSNGHLVKRLEKMKANRSAL 636
D+ LE L + LE+ + N A+
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Score = 38.1 bits (87), Expect = 0.025
Identities = 36/155 (23%), Positives = 74/155 (47%), Gaps = 22/155 (14%)
Query: 250 DTSISIDTEASIREIKELN-ELKDQIQDVEG----KYMQGLKEMKDSLAEVEEKYKK--- 301
+ S + E++ ++++ N EL+ ++ ++EG K+ + ++ +A++EE+ ++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 302 ----AMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQ-------LAESRRQYEEKNKEFER 350
A S Q D + + QV+ + M + +EQ + + +RQ EE +E +R
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 351 EKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
LQ E+ EA + E M E+ L+ K
Sbjct: 1896 INANRRKLQ---RELDEATESNEAMGREVNALKSK 1927
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 72.8 bits (177), Expect = 9e-13
Identities = 95/437 (21%), Positives = 189/437 (43%), Gaps = 61/437 (13%)
Query: 254 SIDTEASIREIK--ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDN 311
SI E RE+K L E ++ V+ + L+ +K+ AE E+ S + N
Sbjct: 774 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 833
Query: 312 EKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV------ 365
+ Q + L L +L E LA+ ++ EK++ E+ A L+ AE+
Sbjct: 834 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 893
Query: 366 --KEALKQREEML---EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSV 420
+ K +E+ ++ +LQ K + S LQ++IE D + A + Q+E
Sbjct: 894 NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKH 951
Query: 421 RSERDDLREEVVMLKEELK----------------------KHGIILNSEIATNGETSDT 458
E+ +L ++ L+++++ KH IL + T +T D
Sbjct: 952 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1011
Query: 459 L-----NNVGYQGPTKMTKEELNALKS--TGDGTLDIRLKKLVDERECL--LEQIKKLKG 509
L N G + +++ + K+ T + + I + ++ E L LE K+
Sbjct: 1012 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1071
Query: 510 QLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR--DANRQISDLKFKLAKSEQEITALE 567
+L+ K +NL++ ++ L ++ ++ Q+ + ++I LK A+ Q+++AL+
Sbjct: 1072 KLQNELDTLKENNLKNVEE-LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1130
Query: 568 QNVIRLESQVSRYKSAAENAEKIEDELKAEKRKL----QRELRSALDKTEELEVSNGHLV 623
+ ++L ++ R + + +K+E+E +L +RE + D EE
Sbjct: 1131 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE--------K 1182
Query: 624 KRLEKMKANRSALLSQQ 640
L+K + SALL+++
Sbjct: 1183 ASLQKSISITSALLTEK 1199
Score = 54.3 bits (129), Expect = 3e-07
Identities = 89/431 (20%), Positives = 181/431 (41%), Gaps = 77/431 (17%)
Query: 258 EASIREIKEL----NELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE- 312
E +EIK L +L + + ++ K KE D +A + K + A+ S+ Q E
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYE------EKNKEFEREKHAHSILQFQFAEVK 366
K +F + T EL+ Q+ + R Y+ + ++ ER HA + + A++
Sbjct: 596 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR-AKLM 654
Query: 367 EALKQREEMLEEIRQ--------------------------------LQQKQASSIREIS 394
+ +K++E LE IR LQ K + I
Sbjct: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714
Query: 395 DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGE 454
+ ++ ++K+ L+ ++ +SE LR+++ ++++K I N+E +
Sbjct: 715 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 774
Query: 455 TSDTLNNVGYQGPTKMTK-----EELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKG 509
+ L K+T E++ +K T + L I +K + E + +
Sbjct: 775 ITRELQG----RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE------EAVSV 824
Query: 510 QLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQN 569
Q ++ + KL + ++L + DL++ ++D++ K + ++ L +
Sbjct: 825 QRSMQETVNKLHQKEEQFNMLSS-------DLEK-LRENLADMEAKFREKDEREEQLIKA 876
Query: 570 VIRLESQVSR-YKSAAENAE---KIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
+LE+ ++ K + +N+ K+ DEL+ ++R ++ EL+ L K E + L K
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE-ELQLKLTKANE---NASFLQKS 932
Query: 626 LEKM--KANRS 634
+E M KA +S
Sbjct: 933 IEDMTVKAEQS 943
Score = 44.3 bits (103), Expect = 4e-04
Identities = 70/333 (21%), Positives = 133/333 (39%), Gaps = 62/333 (18%)
Query: 185 APSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSS 244
A E SG L +A A+A+ E+ + M TLASL T
Sbjct: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQI------MEQMTKEKTETLASLEDTKQ 1068
Query: 245 RRGSGDTSISIDTEASIREIKELNELKD--------------------QIQDVEGKYMQG 284
+ E +++ ++ELN+ K+ Q + + +
Sbjct: 1069 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1128
Query: 285 LKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK----DMLLELEEQLAESRRQ 340
L+E LAE + + + S+ +L+ E++ Q+ +K + + +E+ A ++
Sbjct: 1129 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
Query: 341 YE-------EKNKEFEREKHAHSILQFQFAEVK------EALKQREEMLE-EIRQLQQKQ 386
EK+ E E+ ++ ++L+ + A K + L+ + LE +++ L+ +
Sbjct: 1189 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1248
Query: 387 ASSIREISDLQ-ETIEWKDKKIGALERQKEFFDSV----RSERDDLREEVVMLKEELKKH 441
+ R++S T D+ A E Q +F +SV + + DL+ +V M+
Sbjct: 1249 KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM------- 1301
Query: 442 GIILNSEIATNGETSDTLNNVGYQGPTKMTKEE 474
SE A NG D LNN K +K++
Sbjct: 1302 -----SEAALNG-NGDDLNNYDSDDQEKQSKKK 1328
Score = 38.5 bits (88), Expect = 0.019
Identities = 59/305 (19%), Positives = 127/305 (41%), Gaps = 30/305 (9%)
Query: 338 RRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQ 397
RR + +R A S+ + V ++ R + + + A I + LQ
Sbjct: 297 RRVMATTSASLKRSPSASSLSSM--SSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
Query: 398 ETIEWKDKKIGAL--ERQKEFFDSVR--SERDDLREEVVMLKEELKKHGIILNSEIATNG 453
E ++ K + I L ER E + + S ++ +E+ + ++ +H + L +++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM---- 410
Query: 454 ETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEE 513
D L + + + E LN L+ K+ V++ + +E+ KG LE
Sbjct: 411 ---DQLRTM-VEAADREKVELLNQLEEE---------KRKVEDLQFRVEEESITKGDLEV 457
Query: 514 RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRL 573
K + E D+ ++ + + ++N+ D+ L+ QEI++L++ +
Sbjct: 458 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL-QEISSLQEKL--- 513
Query: 574 ESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANR 633
+V+R E +++ A + Q+E+++ TE+L N L +LE
Sbjct: 514 --EVTRTDHQRE-ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 570
Query: 634 SALLS 638
S +++
Sbjct: 571 SDVIA 575
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 72.8 bits (177), Expect = 9e-13
Identities = 95/437 (21%), Positives = 189/437 (43%), Gaps = 61/437 (13%)
Query: 254 SIDTEASIREIK--ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDN 311
SI E RE+K L E ++ V+ + L+ +K+ AE E+ S + N
Sbjct: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868
Query: 312 EKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV------ 365
+ Q + L L +L E LA+ ++ EK++ E+ A L+ AE+
Sbjct: 869 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 928
Query: 366 --KEALKQREEML---EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSV 420
+ K +E+ ++ +LQ K + S LQ++IE D + A + Q+E
Sbjct: 929 NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKH 986
Query: 421 RSERDDLREEVVMLKEELK----------------------KHGIILNSEIATNGETSDT 458
E+ +L ++ L+++++ KH IL + T +T D
Sbjct: 987 EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1046
Query: 459 L-----NNVGYQGPTKMTKEELNALKS--TGDGTLDIRLKKLVDERECL--LEQIKKLKG 509
L N G + +++ + K+ T + + I + ++ E L LE K+
Sbjct: 1047 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1106
Query: 510 QLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR--DANRQISDLKFKLAKSEQEITALE 567
+L+ K +NL++ ++ L ++ ++ Q+ + ++I LK A+ Q+++AL+
Sbjct: 1107 KLQNELDTLKENNLKNVEE-LNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1165
Query: 568 QNVIRLESQVSRYKSAAENAEKIEDELKAEKRKL----QRELRSALDKTEELEVSNGHLV 623
+ ++L ++ R + + +K+E+E +L +RE + D EE
Sbjct: 1166 EENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE--------K 1217
Query: 624 KRLEKMKANRSALLSQQ 640
L+K + SALL+++
Sbjct: 1218 ASLQKSISITSALLTEK 1234
Score = 54.3 bits (129), Expect = 3e-07
Identities = 89/431 (20%), Positives = 181/431 (41%), Gaps = 77/431 (17%)
Query: 258 EASIREIKEL----NELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE- 312
E +EIK L +L + + ++ K KE D +A + K + A+ S+ Q E
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYE------EKNKEFEREKHAHSILQFQFAEVK 366
K +F + T EL+ Q+ + R Y+ + ++ ER HA + + A++
Sbjct: 631 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR-AKLM 689
Query: 367 EALKQREEMLEEIRQ--------------------------------LQQKQASSIREIS 394
+ +K++E LE IR LQ K + I
Sbjct: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 749
Query: 395 DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGE 454
+ ++ ++K+ L+ ++ +SE LR+++ ++++K I N+E +
Sbjct: 750 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 809
Query: 455 TSDTLNNVGYQGPTKMTK-----EELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKG 509
+ L K+T E++ +K T + L I +K + E + +
Sbjct: 810 ITRELQG----RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE------EAVSV 859
Query: 510 QLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQN 569
Q ++ + KL + ++L + DL++ ++D++ K + ++ L +
Sbjct: 860 QRSMQETVNKLHQKEEQFNMLSS-------DLEK-LRENLADMEAKFREKDEREEQLIKA 911
Query: 570 VIRLESQVSR-YKSAAENAE---KIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
+LE+ ++ K + +N+ K+ DEL+ ++R ++ EL+ L K E + L K
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE-ELQLKLTKANE---NASFLQKS 967
Query: 626 LEKM--KANRS 634
+E M KA +S
Sbjct: 968 IEDMTVKAEQS 978
Score = 52.4 bits (124), Expect = 1e-06
Identities = 95/503 (18%), Positives = 210/503 (41%), Gaps = 46/503 (9%)
Query: 155 AARPSGSYRASVLDEGSFGGTRR--GSTSGSRAPSEYSGHLNS--SSRASSRASSARASP 210
++RPS R +L E S R+ G+T+ A E H+ + R RA A+A+
Sbjct: 327 SSRPS---RTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATS 383
Query: 211 VVEERPEKDFTEKGSRNMPGLSA-ATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE 269
V E ++ + + L A + L + E R++++L
Sbjct: 384 HVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQF 443
Query: 270 LKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLE 329
++ +G K + E+E+ +L E + + K ++E
Sbjct: 444 RVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIME 503
Query: 330 LEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASS 389
LE+ LA ++ E + E K A + + + + +E LE R Q++ +S
Sbjct: 504 LEKDLALRVQEVAELRRRLESNKPAGDV--DMSLSLLQEISSLQEKLEVTRTDHQREITS 561
Query: 390 IREISDLQETIEWKDKK--IGALERQKEFFDSVRSERDDLREE----VVMLKEELKKHGI 443
++E +E K+ K A E+ + +S++S+ + +E + + K +L+
Sbjct: 562 LKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE---- 617
Query: 444 ILNSEIATNGETSDTLNNVGYQGPTKMT------KEELNALKSTGDGTLDIRLKKLVDER 497
+ IA++ + + L +G T K ++ ++ ++ + ER
Sbjct: 618 ---TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER 674
Query: 498 ECLLEQIKKLKGQLEE--RQKIGKLDNLRSEDDVLENGTDMHVMDLQ------RDANRQI 549
++++ L+ +L + ++K L+ +RS+ L+ D H+++++ ++A ++
Sbjct: 675 AAHAKEMEALRAKLMKVIKEKENSLEAIRSK---LDKAEDQHLVEMEDTLNKLQEAEIKV 731
Query: 550 SDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL 609
+L+ AK ++ ++ +L++ + + K E K+E +KL+++L +A
Sbjct: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD-LDALRKASSEGKSEMKKLRQQLEAAE 790
Query: 610 DKTEELEVSNGHLVKRLEKMKAN 632
+ + LE+ K E KA+
Sbjct: 791 KQIKHLEIE-----KNAESSKAS 808
Score = 44.3 bits (103), Expect = 4e-04
Identities = 70/333 (21%), Positives = 133/333 (39%), Gaps = 62/333 (18%)
Query: 185 APSEYSGHLNSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSS 244
A E SG L +A A+A+ E+ + M TLASL T
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQI------MEQMTKEKTETLASLEDTKQ 1103
Query: 245 RRGSGDTSISIDTEASIREIKELNELKD--------------------QIQDVEGKYMQG 284
+ E +++ ++ELN+ K+ Q + + +
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163
Query: 285 LKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK----DMLLELEEQLAESRRQ 340
L+E LAE + + + S+ +L+ E++ Q+ +K + + +E+ A ++
Sbjct: 1164 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223
Query: 341 YE-------EKNKEFEREKHAHSILQFQFAEVK------EALKQREEMLE-EIRQLQQKQ 386
EK+ E E+ ++ ++L+ + A K + L+ + LE +++ L+ +
Sbjct: 1224 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1283
Query: 387 ASSIREISDLQ-ETIEWKDKKIGALERQKEFFDSV----RSERDDLREEVVMLKEELKKH 441
+ R++S T D+ A E Q +F +SV + + DL+ +V M+
Sbjct: 1284 KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM------- 1336
Query: 442 GIILNSEIATNGETSDTLNNVGYQGPTKMTKEE 474
SE A NG D LNN K +K++
Sbjct: 1337 -----SEAALNG-NGDDLNNYDSDDQEKQSKKK 1363
Score = 37.0 bits (84), Expect = 0.056
Identities = 59/291 (20%), Positives = 133/291 (45%), Gaps = 50/291 (17%)
Query: 365 VKEALKQREEMLEEI---RQLQQKQ-ASSIREISDLQETI----EWKDKKIGALERQKEF 416
++EALK++++ +E++ R L++ + A + + ++++ + + D+ + LE + +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 417 FDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELN 476
++ D + E++ EE K+ + D V + TK E
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKR-------------KVEDLQFRVEEESITKGDLETQT 459
Query: 477 ALKSTGDGTLDIRLKKLVDERECLLEQIK--KLKGQLEERQKIGKLDNLRSEDDVLENGT 534
L+ R+K+L E+ L E+ K KL+ +LE+ ++ + + ++E
Sbjct: 460 KLEHA-------RIKEL--EQSLLFEKTKADKLQRELEDT----RVATVSEKSRIMELEK 506
Query: 535 DM-----HVMDLQR--DANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENA 587
D+ V +L+R ++N+ D+ L+ QEI++L++ + +V+R E
Sbjct: 507 DLALRVQEVAELRRRLESNKPAGDVDMSLSLL-QEISSLQEKL-----EVTRTDHQRE-I 559
Query: 588 EKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLS 638
+++ A + Q+E+++ TE+L N L +LE S +++
Sbjct: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 72.8 bits (177), Expect = 9e-13
Identities = 104/494 (21%), Positives = 208/494 (42%), Gaps = 106/494 (21%)
Query: 218 KDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE-------- 269
++ E+ ++N+ LAS TS + +G TE ++ ++E NE
Sbjct: 793 RESVEEATKNVE-----VLASRSNTSEQDQAG-------TEMRVKLLQEENEKLQGRSEE 840
Query: 270 -------LKDQIQDVEG----------KYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNE 312
L+ QI+D++G KY +++++++L ++ K+A+ + L+NE
Sbjct: 841 LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE 900
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNK---EFEREK----HAHSILQFQFAEV 365
+ +L E+L E Q E+ + E E E+ LQ + A++
Sbjct: 901 LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERD 425
EA R LE QL + + + RE++++Q ++ K LE +K +++
Sbjct: 961 VEA--SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK-----TLEAEKSRLTAMK---- 1009
Query: 426 DLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTK--MTKEELNALKSTGD 483
+++E+ +++EEL+ + + + TL ++ Y+ K + + +K D
Sbjct: 1010 -MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
Query: 484 --GTLDIRLKKLVDERECLLEQIKKLKGQLEE------RQKIGKLD-------------N 522
L++ L++ + + L E+I + + Q+E+ +++ + D +
Sbjct: 1069 KVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKD 1128
Query: 523 LRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRY-- 580
L+S LE L +I++L+ +L E++ L+ + RLE +V
Sbjct: 1129 LKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVM 1188
Query: 581 -----------------------KSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEV 617
K E AE+ D L++ K+KLQREL +D E L+
Sbjct: 1189 QVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
Query: 618 SNGHLVK--RLEKM 629
+ K RL+K+
Sbjct: 1249 QLNSMKKDLRLKKL 1262
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/516 (20%), Positives = 201/516 (38%), Gaps = 80/516 (15%)
Query: 134 GELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHL 193
G +G+ + R +P+ GS ++V+ RAPS L
Sbjct: 449 GAAHGASCAHSRPPQPNIDGKVLETEGSQESTVI----------------RAPS-----L 487
Query: 194 NSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRG--SGDT 251
+ S+ +A A+ +++ R + G++ +S T S T + G
Sbjct: 488 GAQSKKEEEVKTATATLMLQNRATATSPDSGAKK---ISVKTFPSASNTQATPDLLKGQQ 544
Query: 252 SISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDN 311
++ T + N LK+ D + K + + E + K +AQ +N
Sbjct: 545 ELTQQTNEETAKQILYNYLKEGSTDND----DATKRKVNLVFEKIQTLKSRAAGSAQGNN 600
Query: 312 EKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQ 371
+ N +V L + +L ++AE +RQ LQ + + ++
Sbjct: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQ-----------------LQLEVKNQQNIKEE 643
Query: 372 REEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
RE M + +L+ + + E S LQ+ +E + G L + E V+ ER+ + E+
Sbjct: 644 RERMRANLEELRSQHNEKVEENSTLQQRLEESE---GELRKNLEELFQVKMEREQHQTEI 700
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
L+++L + L+S + L Q K++L L + D+ K
Sbjct: 701 RDLQDQLSEMHDELDSAKRSEDREKGALIEELLQA-----KQDLQDLLIAKEEQEDLLRK 755
Query: 492 KLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR---DANRQ 548
+ ERE + LKG L+E ++ + E D L+ D + L+ +A +
Sbjct: 756 R---ERE-----LTALKGALKE-----EVSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 549 ISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEK--------IEDELKAEKRK 600
+ L + SEQ+ E V L+ + + + +E E+ IED LK ++ K
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIED-LKGDEAK 861
Query: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSAL 636
+ L+ + +LE + H K ++ + R AL
Sbjct: 862 AKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL 897
Score = 48.1 bits (113), Expect = 2e-05
Identities = 76/317 (23%), Positives = 145/317 (45%), Gaps = 49/317 (15%)
Query: 258 EASIREIKELN-ELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 316
E + RE+ E+ +LK++ + E + +K M+D + +EE+ + AQ D T
Sbjct: 980 EKNRRELAEMQRQLKEKTLEAEKSRLTAMK-MQDEMRLMEEELRD--YQRAQ-DEALTKR 1035
Query: 317 MYQVDTLKDMLLELEEQ--LAESR----RQYEEK----NKEFEREKHAHSILQFQFAEVK 366
TLKD+ ELE + L + R +Q E+K E E E++ +L + + +
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
Query: 367 EALKQ-REEMLEEIRQLQQKQASSI---REISDLQETI-----EWKDKKIGALERQK--- 414
E ++Q R E+L+E Q + I R+ DL+ I ++ K G + + +
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
Query: 415 -EFFDSVRSERDD---LREEVVMLKEELKKHGIILNSEIATNGETSD--TLNNVGYQGPT 468
E D + SE D L+ L+ ++K+ + ++ E + + D +L +
Sbjct: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQV 1215
Query: 469 KMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGK--------L 520
+ +EE++ L+S+ KKL E E ++ + L+GQL +K + L
Sbjct: 1216 EEAEEEIDRLESSK--------KKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVL 1267
Query: 521 DNLRSEDDVLENGTDMH 537
D++ +DD+ +G ++
Sbjct: 1268 DDMDDDDDLSTDGGSLY 1284
Score = 32.3 bits (72), Expect = 1.4
Identities = 47/224 (20%), Positives = 94/224 (41%), Gaps = 40/224 (17%)
Query: 213 EERPEKDF-TEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELK 271
EER D +E+ SR+ + L ++R+ IS++ ++ +LK
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE--------RQNKDLK 1130
Query: 272 DQIQDVEGKYMQGLK----EMKDSLAEVEEKYKKAMV--SNAQLDNEKTNFMYQVDTLKD 325
+I +EG Y + +M+ +AE+E++ + +N QL N +
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR------------ 1178
Query: 326 MLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQK 385
LE ++ E Q ++++ +K S+ +K +Q EE EEI +L+
Sbjct: 1179 ----LERKVKELVMQVDDEHLSLTDQKDQLSL------RLKAMKRQVEEAEEEIDRLESS 1228
Query: 386 QASSIREISDLQETIEWKDKKIGALE---RQKEFFDSVRSERDD 426
+ RE+ + + E ++ +++ R K+ V + DD
Sbjct: 1229 KKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDD 1272
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 72.4 bits (176), Expect = 1e-12
Identities = 95/427 (22%), Positives = 182/427 (42%), Gaps = 91/427 (21%)
Query: 255 IDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEV-------EEKYK------- 300
+ TEA ++K+L E + ++D K + K ++D +AE EEK K
Sbjct: 967 VTTEA---KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 301 --KAMVSNAQ----------LDNEKTNFMYQVDT--LKDMLLELEEQLAESRRQYEEKNK 346
+AM+++ + + EKT + D+ L D + EL+ Q+AE + Q +K +
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 347 EFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKK 406
E LQ A V+E Q+ L++IR+L+ +IS+LQE +E +
Sbjct: 1084 E----------LQAALARVEEEAAQKNMALKKIRELES-------QISELQEDLESERAS 1126
Query: 407 IGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQG 466
E+QK DL EE+ LK EL+ DTL++ Q
Sbjct: 1127 RNKAEKQKR----------DLGEELEALKTELE-----------------DTLDSTAAQQ 1159
Query: 467 PTKMTKE-ELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRS 525
+ +E E+N LK T + ++ + R+ + +++L QLE+ +++ NL
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA--NLEK 1217
Query: 526 EDDVLEN-----GTDMHVM--------DLQRDANRQISDLKFKLAKSEQEITALEQNVIR 572
LEN ++ V+ ++ Q+ +L+ K + E+ T L V +
Sbjct: 1218 AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTK 1277
Query: 573 LESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKAN 632
L+ ++ ++ +L + L+ +L+ + +E L +L++++
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Query: 633 RSALLSQ 639
+++ Q
Sbjct: 1338 KNSFREQ 1344
Score = 70.5 bits (171), Expect = 5e-12
Identities = 103/452 (22%), Positives = 187/452 (41%), Gaps = 96/452 (21%)
Query: 265 KELNELKDQI---------QDVEGKYMQGLKEMKDSL-AEVEEKYKKAMVSNAQLDNEKT 314
KE L+D+I ++ + K + LK +++ ++EE+ ++ +L+ +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
L D + EL+ Q+AE + Q +K +E LQ A V+E Q+
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE----------LQAALARVEEEAAQKNM 1101
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQK----EFFDSVRSERDDL--- 427
L++IR+L+ +IS+LQE +E + E+QK E +++++E +D
Sbjct: 1102 ALKKIRELES-------QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154
Query: 428 -----------REEVVMLKEELKKHGIILNSEIATNGET-SDTLNNVGYQ-GPTKMTKEE 474
+EV +LK+ L++ ++I + S + + Q TK K
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKAN 1214
Query: 475 LNALKSTGD---GTLDIRLKKLVDERECLLEQIKKLKGQLEERQ-KIGKLDNLRSE--DD 528
L K T + G L +K L+ + + KK++ QL+E Q K + + +R+E D
Sbjct: 1215 LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADK 1274
Query: 529 V------LENGTDM-----------------------HVMDLQRDANRQISDLKFKLAKS 559
V L+N T + +L ++ NRQ L KL +
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334
Query: 560 EQEITA--------------LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQREL 605
E E + LE+ + L +QV+ K E++ + + KRKLQ++L
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Query: 606 RSALDKTEELEVSNGHLVKRLEKMKANRSALL 637
+ EE + L K +++ LL
Sbjct: 1395 EGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Score = 69.7 bits (169), Expect = 8e-12
Identities = 80/389 (20%), Positives = 171/389 (43%), Gaps = 48/389 (12%)
Query: 269 ELKDQIQDVEGKYMQGLK---EMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
+++ Q+Q+++ K+ +G + E+ D + +++ + +Q D++ + L+
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 326 MLLELEEQLAESRRQY-----------EEKN---KEFEREKHA-HSI------LQFQFAE 364
L + +E L E RQ +EKN ++ E E+ A H++ L Q A+
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 365 VKEALKQREEMLEEIRQLQQKQASSIREISDL-QETIEWKDKKIGALERQKEFFDSVRSE 423
+K+ ++ LE ++++K + +S +E + DK R ++ D + +
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 424 RDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGD 483
D R+ L+++ KK +L E + + ++ + + K TK
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA---------- 1478
Query: 484 GTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR 543
+ L + ++E ++++L Q + D + S+DDV G +H ++ +
Sbjct: 1479 ----LSLARALEEAMEQKAELERLNKQFRTEME----DLMSSKDDV---GKSVHELEKSK 1527
Query: 544 DA-NRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK-L 601
A +Q+ ++K +L + E E+ A E +RLE + K+ E + DE EK+K L
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 602 QRELRSALDKTEELEVSNGHLVKRLEKMK 630
R++R + E+ V +K++
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLE 1616
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/413 (20%), Positives = 178/413 (43%), Gaps = 62/413 (15%)
Query: 258 EASIREIK-ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 316
E + E+K +L EL+D++Q E ++ ++ +L ++ ++++ + + EK
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLR----LEVNLQAMKAQFERDLQGRDEQSEEKK-- 1584
Query: 317 MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEML 376
K ++ ++ E AE + ++++ K L+ A + A K R+E +
Sbjct: 1585 -------KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 377 EEIRQLQQKQASSIREISDLQETIEW-------KDKKIGALER-----QKEFFDSVRS-- 422
+++R+LQ + +RE+ D + + E +KK+ ++E Q+E + R+
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 423 ----ERDDLREEV--------VMLKEELKKHGII--LNSEIATNGETSDTLNNVGYQGPT 468
ERD+L +E+ + L+E+ + I L E+ ++ +N+
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND------- 1750
Query: 469 KMTKEELNALKSTGDGTLD-IRLKKLVDERECLLEQIKKLKGQLEERQKIGK------LD 521
++ K L + D L+ +K + R+ L Q K+LK +L+E + K +
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 522 NLRSEDDVLENGTDMHVMDLQ------RDANRQISDLKFKLAKSEQEITALEQNVIRLES 575
L ++ LE D + Q R +++ D+ ++ + + + +
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870
Query: 576 QVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEK 628
++ + K E AE+ A +RKLQREL A + + + L +L +
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/326 (20%), Positives = 146/326 (44%), Gaps = 44/326 (13%)
Query: 313 KTNFMYQVDTLKDMLLELEEQLAESR-RQYEEKNKEFEREKHAHSILQFQFAEVKEALKQ 371
K + QV ++ ++ EE+L + R +Q +N+ E E S L + +++E L+
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET-LQSQLMAEKLQLQEQLQA 891
Query: 372 REEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
E+ E +L+ + + +E+ ++ +E + +E ++E +++E+ +++ +
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEAR------VEEEEERCQHLQAEKKKMQQNI 945
Query: 432 VMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
L+E+L++ + L V + K +EE L+
Sbjct: 946 QELEEQLEEE---------ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC-------- 988
Query: 492 KLVDERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQIS 550
KL E++ L ++I + L EE +K L L+++ + + TD+ + R +Q
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI--TDLE--ERLRREEKQRQ 1044
Query: 551 DLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALD 610
+L+ K E + T L + L++Q++ ELK + K + EL++AL
Sbjct: 1045 ELEKTRRKLEGDSTDLSDQIAELQAQIA--------------ELKMQLAKKEEELQAALA 1090
Query: 611 KTEELEVSNGHLVKRLEKMKANRSAL 636
+ EE +K++ ++++ S L
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISEL 1116
Score = 56.6 bits (135), Expect = 7e-08
Identities = 75/430 (17%), Positives = 188/430 (43%), Gaps = 66/430 (15%)
Query: 262 REIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD 321
R+ L+ Q++D + + + L+E +++ +E++ A + + + + ++
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 322 TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQF--------------AEVKE 367
T +++ +L++ L +++EEK +++ + + LQ + +++
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 368 ALKQREEMLEEIR---------------QLQQKQASSIREISDLQETIEWKDKKIGALER 412
K+ +++L E + + ++K+ ++ L+E +E K LER
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK----AELER 1497
Query: 413 QKEFFDSVRSERDDL---REEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTK 469
+ F R+E +DL +++V EL+K L ++ + L +
Sbjct: 1498 LNKQF---RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 470 MTKEELN--ALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGK-------- 519
+ E+N A+K+ + L R ++ ++++ L+ Q+++++ +LE+ +K
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK 1614
Query: 520 ----LDNLRSEDDVLENGTDMHVMDLQ------RDANRQISDLK-------FKLAKSEQE 562
L +L + D D + L+ +D R++ D + + ++E++
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 563 ITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHL 622
+ ++E +I+L+ +++ + A A++ DEL E + AL++ LE L
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL 1734
Query: 623 VKRLEKMKAN 632
+ LE+ + N
Sbjct: 1735 EEELEEEQGN 1744
Score = 54.3 bits (129), Expect = 3e-07
Identities = 87/445 (19%), Positives = 187/445 (42%), Gaps = 35/445 (7%)
Query: 205 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 264
S RAS E+ ++D E+ L TL S R + ++I + ++ E
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELED-TLDSTAAQQELRSKREQEVNI-LKKTLEEE 1179
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
+ +E QIQ++ K+ Q ++E+ + L + + + L+NE+ +V L
Sbjct: 1180 AKTHEA--QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 384
+ E + + Q +E +F + + L + +++ L +L +
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 385 KQASSIR----EISDLQETIEWKDK-KIGALERQKEFFDSVRSERDDLREEVVMLKEELK 439
K ++ D QE ++ +++ K+ + K+ D S R+ L EE K L+
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA-KHNLE 1356
Query: 440 KHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIR-LKKLVDERE 498
K L++++A + + ++VG + K +L D+ L + +E+
Sbjct: 1357 KQIATLHAQVADMKKKME--DSVGCLETAEEVKRKLQK---------DLEGLSQRHEEKV 1405
Query: 499 CLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAK 558
++++K K +L++ +LD+L + D + + ++ Q+ ++ +++ K AK
Sbjct: 1406 AAYDKLEKTKTRLQQ-----ELDDLLVDLDH-QRQSACNLEKKQKKFDQLLAEEKTISAK 1459
Query: 559 SEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE----- 613
+E E E++ A E A + + EL+ ++ + E+ + +
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 614 --ELEVSNGHLVKRLEKMKANRSAL 636
ELE S L +++E+MK L
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEEL 1544
Score = 49.7 bits (117), Expect = 8e-06
Identities = 58/284 (20%), Positives = 122/284 (42%), Gaps = 29/284 (10%)
Query: 362 FAEVKEAL---KQREEML---EEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKE 415
F +VK L +Q EEM+ EE+ ++++KQ ++ +++++ + L+ Q +
Sbjct: 831 FTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQ 890
Query: 416 FFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEEL 475
+ +E ++LR + K+EL++ L + + E L Q K ++ +
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL-----QAEKKKMQQNI 945
Query: 476 NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTD 535
L E + E+ + K QLE+ KL L E +LE+ +
Sbjct: 946 QEL-----------------EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED-QN 987
Query: 536 MHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELK 595
+ ++ +I++ L + E++ +L + + E+ ++ + EK EL+
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE 1047
Query: 596 AEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+RKL+ + D+ EL+ L +L K + A L++
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Score = 48.5 bits (114), Expect = 2e-05
Identities = 81/393 (20%), Positives = 162/393 (41%), Gaps = 88/393 (22%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q +++ K + +K + LA E + + +QL EK Q+
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 323 LKDMLLELEE---QLAESRRQYEE--------KNKEFEREKHAHSI---LQFQFAEVKEA 368
++ E EE +L +++ EE +E ER +H + +Q E++E
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 369 LKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLR 428
L++ E +++ QL+ + T E K KK L
Sbjct: 952 LEEEESARQKL-QLE-------------KVTTEAKLKK--------------------LE 977
Query: 429 EEVVMLKEE---LKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGT 485
EE ++L+++ L K +L IA + T +T+EE +
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIA--------------EFTTNLTEEEEKSKS------ 1017
Query: 486 LDIRLKKLVDERECLLEQI-KKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRD 544
L KL ++ E ++ + ++L+ + ++RQ++ K D TD+ D +
Sbjct: 1018 ----LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD-----STDL--SDQIAE 1066
Query: 545 ANRQISDLKFKLAKSEQEITA----LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK 600
QI++LK +LAK E+E+ A +E+ + + + + +++++L++E+
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANR 633
+ + D EELE L L+ A +
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/391 (20%), Positives = 165/391 (42%), Gaps = 50/391 (12%)
Query: 264 IKELNELKDQIQDVEGKYMQGLKEMKD----------SLAEVEEKYKKAMVSNAQLDNEK 313
IKE ++D+I + + + ++ K+ ++++EE+ KK + +L+ K
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 314 TNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQRE 373
+ L+D + EL+ Q+ E + Q +K +E LQ A + +
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE----------LQGALARGDDETLHKN 1107
Query: 374 EMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVM 433
L+ +R+LQ +I++LQE E + E+QK DL EE+
Sbjct: 1108 NALKVVRELQ-------AQIAELQEDFESEKASRNKAEKQKR----------DLSEELEA 1150
Query: 434 LKEELKK--HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLK 491
LK EL+ E+ T E + TK + ++ ++ R
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ--------RHA 1202
Query: 492 KLVDERECLLEQIKKLKGQLEERQKIGKLDN--LRSEDDVLENGTDMHVMDLQRDANRQI 549
++E LEQ K+ K LE+ ++ + DN L E VL+ ++ + Q+
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ-VKAESEHKRKKLDAQV 1261
Query: 550 SDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL 609
+L K+++ ++ L + +L++++ + E AEK + + L+ +L+
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 610 DKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+ +E +L R+ +++ +++L QQ
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/402 (21%), Positives = 172/402 (42%), Gaps = 54/402 (13%)
Query: 250 DTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKK---AMVSN 306
D + ++ + + +L+ + + E K +K++++ AE+E++ K+ A+ S
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619
Query: 307 AQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVK 366
+++ + + Q++ E+ +QL + + Q ++ +E E + + + FA+ K
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI---FAQSK 1676
Query: 367 EALKQREEMLEEIRQLQQKQASSIREISDL-QETIEWKDKKIGALERQKEFFDSVRSERD 425
E+ K+ + + EI QLQ++ ASS R QE E D+ + + D E+
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD----EKR 1732
Query: 426 DLREEVVMLKEELKKHGI---ILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTG 482
L + L+EEL++ +LN DTLN EL A +S
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN------------AELAAERSAA 1780
Query: 483 DGTLDIRLKKLVDERECLLEQIKKLKGQLEERQ----------------KIGKLDNLRSE 526
+K + R+ L Q K+LK +L+E + KIG+L+ + E
Sbjct: 1781 --------QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE-QLE 1831
Query: 527 DDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAEN 586
+ E L R +++ ++ ++ + ++ + + +++ + K E
Sbjct: 1832 QEAKERAA---ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 587 AEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEK 628
AE+ A +RKLQREL A + E L L RL +
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/409 (20%), Positives = 182/409 (44%), Gaps = 54/409 (13%)
Query: 265 KELNELKDQIQDVEGKY------MQGLKEMKDSLAEVEEKYKKAMVSNA----QLDNEKT 314
K++ L+ Q+ D + K ++ L+E K L + E + + A +L+ K
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
++D D+ ++L+ Q + E+K K+F++ + ++AE +R+
Sbjct: 1424 RLQQELD---DLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAE------ERDR 1473
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
E R+ + K S R L+E +E K++ ++ + + + S +DD+ + V
Sbjct: 1474 AEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV--- 1527
Query: 435 KEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELN--ALKSTGDGTLDIRLKK 492
EL+K L ++ + L + + E+N A+K+ + L R ++
Sbjct: 1528 -HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 493 LVDERECLLEQIKKLKGQLEERQKIGKL------------DNLRSEDDVLENGTDMHVMD 540
+++ L++Q+++L+ +LE+ +K L +L ++ + D +
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 541 LQR------DANRQISDLK------FKLAK-SEQEITALEQNVIRLESQVSRYKSAAENA 587
L++ D R++ + + F +K SE+++ +LE +++L+ +++ + A +A
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 588 EKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSAL 636
E+ DEL E + LD+ LE L + LE+ ++N L
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 65.1 bits (157), Expect = 2e-10
Identities = 87/385 (22%), Positives = 183/385 (47%), Gaps = 41/385 (10%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKD 325
E +L+DQI +++ + + E+K LA+ EE+ + A+ A+ D+E +++ + LK
Sbjct: 1063 ETTDLQDQIAELQAQ----IDELKLQLAKKEEELQGAL---ARGDDET---LHKNNALK- 1111
Query: 326 MLLELEEQLAESRRQYE-EKNKEFEREKHAHSILQFQFAEVKEALK-QREEMLEEIRQLQ 383
++ EL+ Q+AE + +E EK + EK + +E EALK + E+ L+ Q
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDL-----SEELEALKTELEDTLDTTAAQQ 1166
Query: 384 QKQASSIREISDLQETIEWKDKKIGA-LERQKEFFDSVRSERDDLREEVVMLKEELKKHG 442
+ + +E+++L++ +E + K A ++ ++ + E + E+ K L+K+
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 443 IILNSEIATNGETSDTLNNVGYQGPTKMTK-----EELNALKSTGDGTLDIRLK-KLVDE 496
L ++ L V + K K +EL+A S GD RL+ +L ++
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD-----RLRVELAEK 1281
Query: 497 RECLLEQIKKLKGQLEERQKIG--------KLDN-LRSEDDVLENGT--DMHVMDLQRDA 545
L ++ + LEE +K G L++ L+ ++L+ T +++ R
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 546 NRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQREL 605
+ + L+ + + E+ LE+ V+ L+SQ++ K ++ + L+ K+KL ++
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 606 RSALDKTEELEVSNGHLVKRLEKMK 630
+ + EE ++ L K +++
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQ 1426
Score = 63.2 bits (152), Expect = 7e-10
Identities = 90/402 (22%), Positives = 179/402 (44%), Gaps = 52/402 (12%)
Query: 263 EIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
++K L ++ Q ++++ K + LK +K+ +VE + ++ + QL EK Q+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 323 LKDMLLELEE---QLAESRRQYEE----KNKEFEREKHAHSILQFQFAEVKEALKQREEM 375
++ E EE +LA +++ EE E E+ + ILQ + +++ ++ EE
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 376 LEE----IRQLQQKQASSIREISDLQETI-EWKDKKIGALERQKEFFDSVRSERDDLREE 430
L+E ++LQ ++ ++ +I ++E I +D+ ++ +K D + L EE
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 431 VVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDG-TLDIR 489
+E+ K I N + + + L + T++EL K DG T D++
Sbjct: 1019 ----EEKAKNLAKIRNKQEVMISDLEERLKK------EEKTRQELEKAKRKLDGETTDLQ 1068
Query: 490 LKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM--------DL 541
D+ L QI +LK QL ++++ + R +D+ L + V+ +L
Sbjct: 1069 -----DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 542 QRD----------ANRQISDLKFKLAKSEQEI-TALEQNVIRLESQVSRYKSAAENAEKI 590
Q D A +Q DL +L + E+ L+ + E + R + AE + +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 591 EDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKAN 632
E+E K + ++Q + EEL +++ ++ KAN
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEEL----SEQLEQAKRFKAN 1221
Score = 53.9 bits (128), Expect = 4e-07
Identities = 61/280 (21%), Positives = 122/280 (43%), Gaps = 28/280 (10%)
Query: 361 QFAEVKEALKQREEMLEEIRQLQQKQASSIREISDL-QETIEWKDKKIGALERQKEFFDS 419
Q +E L+ ++E L ++++ Q K + E+ Q+ +E K+ L+ + E F
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF-- 903
Query: 420 VRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 479
+E +++R + K+EL++ L S + E + L N K+++ A
Sbjct: 904 --AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQN---------EKKKMQAHI 952
Query: 480 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 539
L++ +DE E +++ QLE+ K+ + E +LE+ +
Sbjct: 953 QD--------LEEQLDEEEGARQKL-----QLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 540 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 599
+ + +R I++ +LA+ E++ L + + E +S + + EK EL+ KR
Sbjct: 1000 EKKLMEDR-IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
KL E D+ EL+ L +L K + L++
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 72.4 bits (176), Expect = 1e-12
Identities = 90/379 (23%), Positives = 173/379 (45%), Gaps = 29/379 (7%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
+E +L+ Q+ D+ + M L EV+ ++ A L ++ N +++ +
Sbjct: 356 REKQDLEKQMSDL--RVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGE 413
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 384
L++ ++L E + ++ E KHA + ++A KQ E L E++Q +
Sbjct: 414 KQQLQMLDRLKEIQNHFDTCEAE---RKHADLQISELTRHAEDATKQAERYLSELQQSEA 470
Query: 385 KQASSIREISDL----QETI-EWK--DKKIG-ALERQKEFFDSVRSERDDLREEVVMLKE 436
+ + + DL QE+I +WK KK+ ALE+Q E D + + + + +E K+
Sbjct: 471 LKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKE----KD 526
Query: 437 ELKKHGIILNSEIAT-NGETSDTLNNVGYQGPTKMTKEE-LNALKSTGDGTLDIRLKKLV 494
ELK +I E +D L Q +KEE L +KS L++ +K +
Sbjct: 527 ELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSH-QADLELEVKNSL 585
Query: 495 DERECLLEQIKKLKGQLEERQKIGK--LDNLRSEDDVLENGTDMHVMDLQ---RDANRQI 549
D L ++KK + +++ + K+ K L+ +E + ++++Q +D +
Sbjct: 586 DTIHRLESELKK-QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIR 644
Query: 550 SDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSAL 609
+DL KLA+ E+ A+ +++ L +Q KS E I +LK E+ QREL+
Sbjct: 645 ADLANKLAEEERAKKAVLKDLSDLTAQA---KSRDEETATIITQLKLERDVHQRELKDLT 701
Query: 610 DKTEELEVSNGHLVKRLEK 628
+ ++ + ++ L K
Sbjct: 702 SSLQSVKTKHEQNIQELMK 720
Score = 57.8 bits (138), Expect = 3e-08
Identities = 88/458 (19%), Positives = 191/458 (41%), Gaps = 65/458 (14%)
Query: 221 TEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGK 280
T + ++ G + + L TS + GD I S ++ + E D Q + G
Sbjct: 107 TSLSASDLDGGTGSELHHFPPTSPLKDYGDPQ-GIKRMRSRTGVRFVQETDDMTQ-LHG- 163
Query: 281 YMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQ 340
+ Q L+++ + + + + + ++ D E K L EL E+L E+++Q
Sbjct: 164 FHQSLRDLSSEQIRLGDDFNRELSRRSRSDAET----------KRALEELTEKLNEAQKQ 213
Query: 341 ------YEEKNKEFERE--------KHAHSILQFQFAEVKEALKQREEMLEEIR-QLQQK 385
E + +E ERE + L +++EALK++E +E ++ K
Sbjct: 214 EVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNK 273
Query: 386 QASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELK--KHGI 443
+ E + L++ +E + + E +E ++ + ++LR ++ + + K +H +
Sbjct: 274 LRQTETEKNQLEQELELSRRLLNQSEGSRE---TLLHQVEELRTQLTKAEGDRKGLQHQV 330
Query: 444 ILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQ 503
S+I+ ++ + +E+ + K D + + + E LE+
Sbjct: 331 ---SQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASE----LEE 383
Query: 504 IKKL--KGQLEERQKIGKLDNLRSEDDVLENGT--DMHVMDLQRDANRQISDLKFKLAKS 559
+K+ + E+ +++NL E LENG + ++D ++ + + +
Sbjct: 384 VKRCMERKDKEKAHLASQVENLTRE---LENGEKQQLQMLDRLKEIQNHFDTCEAERKHA 440
Query: 560 EQEITALEQNVIRLESQVSRYKSAAENAEKIEDE---------LKAEK---------RKL 601
+ +I+ L ++ Q RY S + +E +++E LKA++ +KL
Sbjct: 441 DLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKL 500
Query: 602 QRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+R L + +EL N ++K +++K A L Q
Sbjct: 501 ERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQ 538
Score = 52.4 bits (124), Expect = 1e-06
Identities = 100/439 (22%), Positives = 183/439 (41%), Gaps = 69/439 (15%)
Query: 257 TEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEV---EEKYKKAMVSNAQLDNEK 313
T+ +++E +EL+ +++++D++ E+K+SL + E + KK +Q+ EK
Sbjct: 551 TKRALQE-EELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEK 609
Query: 314 TNFMYQVDTLKDM-------LLELEEQLAE-SRRQYEEKNKEFEREKHAHSILQFQFAEV 365
+ ++ LK LLE++E + + S + + NK E E+ ++L+
Sbjct: 610 AHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLT 669
Query: 366 KEALKQREEMLEEIRQLQQKQASSIREISDLQETIEW-KDKKIGALERQKEFFDSVRSER 424
+A + EE I QL+ ++ RE+ DL +++ K K ++ + F +SE
Sbjct: 670 AQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEA 729
Query: 425 D--------DLREEVVMLK------EELKKHGIILNSEIATNGETSDTLNNVGYQGPTKM 470
+ + EE M K E+LK L E+ N + L + YQ
Sbjct: 730 ENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLK-LKYQCLKDQ 788
Query: 471 TKE-------ELNALKSTGDGTLDIR--LKKLVDERECLLEQIKKLKGQLEERQKIGKLD 521
+E E L+ + L ++ L L E+E +L I K +++ K D
Sbjct: 789 LEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGK---EIDAACKTFSKD 845
Query: 522 NLRSEDDVLENGTDMHV-----------------MDLQRDANRQISDLKFKLAKSEQEIT 564
++ V +G D+H +L+ NR+ +L+ +L Q++
Sbjct: 846 SVEKLK-VFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENRE-KNLRHQLMLCRQQLR 903
Query: 565 ALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKL-------QRELRSALDKTEELEV 617
L +N ES++ E E++ DE+ EKR L E+ S D+ LE
Sbjct: 904 NLTENK---ESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALET 960
Query: 618 SNGHLVKRLEKMKANRSAL 636
S + LE + S L
Sbjct: 961 STQVALDHLESVPEKLSLL 979
Score = 50.8 bits (120), Expect = 4e-06
Identities = 88/415 (21%), Positives = 170/415 (40%), Gaps = 71/415 (17%)
Query: 262 REIKELNELKDQIQDVEGKYMQGLKE-MKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQV 320
RE++ EL ++ QD G L+E +K A+ +E Q + EK ++
Sbjct: 229 REMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQEL 288
Query: 321 DTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEV-KEALKQREEMLEEI 379
+ + +L + E Q EE + + + LQ Q +++ K+ ++E E+
Sbjct: 289 ELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDW 348
Query: 380 R---------QLQQKQASSIR----------EISDLQETIEWKDKKIGALERQKEFFDSV 420
R Q +KQ S +R E+ +++ +E KDK+ L Q E +
Sbjct: 349 RFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVE--NLT 406
Query: 421 RSERDDLREEVVMLK------------EELKKHGIILNSEIATNGE--TSDTLNNVGYQG 466
R + ++++ ML E +KH + SE+ + E T +
Sbjct: 407 RELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQ 466
Query: 467 PTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKI-----GKLD 521
++ KEE + D++LK R+ L+ KKL+ LE++ + GK +
Sbjct: 467 QSEALKEEAEKRRE------DLKLKAQESIRQWKLKH-KKLERALEKQSETVDELTGKNN 519
Query: 522 NLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYK 581
+ E D L+ + ++ + ++++D+ K A E+E+ + E
Sbjct: 520 QILKEKDELKTQLYAALQQIE-NLRKELNDVLTKRALQEEELHSKE-------------- 564
Query: 582 SAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSAL 636
EK+ D +K+ + L+ E++++LD LE K +MK ++ L
Sbjct: 565 ------EKLRD-IKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHL 612
Score = 45.8 bits (107), Expect = 1e-04
Identities = 67/350 (19%), Positives = 149/350 (42%), Gaps = 34/350 (9%)
Query: 258 EASIREIKELNELKDQIQ----DVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEK 313
E + E+++ LK++ + D++ K + +++ K ++E +K + +L +
Sbjct: 459 ERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKN 518
Query: 314 TNFMYQVDTLKDMLL-----------ELEEQLAESRRQYEEKNKEFEREKHAHSILQFQF 362
+ + D LK L EL + L + Q EE + + E+ + S
Sbjct: 519 NQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLE 578
Query: 363 AEVKEALKQREEMLEEIR-------QLQQKQASSIREISDLQETIEWKDKKIGALERQKE 415
EVK +L + E++ Q++ ++A EI++L+++ K+ ++ +
Sbjct: 579 LEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIK 638
Query: 416 FFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDT------LNNVGYQGPTK 469
++R++ + E K+ + K L ++ + E + T L +Q K
Sbjct: 639 DLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELK 698
Query: 470 MTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQ-LEERQKI----GKLDNLR 524
L ++K+ + + +K E+ I+ LK + LEE+ G+L+ L+
Sbjct: 699 DLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLK 758
Query: 525 SEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLE 574
S+ D L + + + + LK +L + E+ I+ E+++ R+E
Sbjct: 759 SQCDRLTEELTQNENE-NKKLKLKYQCLKDQLEEREKHISIEEEHLRRME 807
Score = 31.6 bits (70), Expect = 2.3
Identities = 33/151 (21%), Positives = 62/151 (41%), Gaps = 7/151 (4%)
Query: 292 LAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFERE 351
LAE + K + + +N + N +Q+ + L L E + E F++
Sbjct: 867 LAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTEN------KESELQCLFQQI 920
Query: 352 KHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALE 411
+ +L E ++ L++ + EE+ LQ + + + +E +K+ LE
Sbjct: 921 ERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLE 980
Query: 412 RQKEFFDSV-RSERDDLREEVVMLKEELKKH 441
K+F DS SER D R ++ +H
Sbjct: 981 DFKDFRDSCSSSERTDGRYSKYRVRRNSLQH 1011
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 71.6 bits (174), Expect = 2e-12
Identities = 95/419 (22%), Positives = 188/419 (44%), Gaps = 39/419 (9%)
Query: 237 ASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVE 296
ASL T R + D E S L++ + V ++ Q L E + L +
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475
Query: 297 EKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHS 356
++ + ++ N + Q++TL+ L+E++++ Q E K + +
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535
Query: 357 ILQFQFAEVKEALKQREEMLE-EIRQLQQKQASSIREISDLQETIEWKDKKIGALER--- 412
+++ + ++++ AL++ E LE E ++ + Q + S+L + KD++I L+R
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 413 ------QKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQG 466
Q +RS D LR + M + +L + I L ET L V QG
Sbjct: 1596 RAAEALQSVLDAEIRSRNDALRLKKKM-EGDLNEMEIQLGHSNRQMAETQKHLRTV--QG 1652
Query: 467 PTKMTKEEL-NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRS 525
K ++ L +AL+S D L +L + LLE+++++K LE+ ++ +L S
Sbjct: 1653 QLKDSQLHLDDALRSNED--LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRL----S 1706
Query: 526 EDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAA 584
E ++L+ + ++ Q N + + K KL + A +E ++ + + K A
Sbjct: 1707 EQELLDASDRVQLLHSQ---NTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 585 ENAEKIEDELKAE----------KRKLQ---RELRSALDKTEELEVSNGHLVKRLEKMK 630
+A + +ELK E K+ L+ ++L+ LD+ E+L + G K+++K++
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQKLE 1820
Score = 68.6 bits (166), Expect = 2e-11
Identities = 69/327 (21%), Positives = 149/327 (45%), Gaps = 19/327 (5%)
Query: 319 QVDTLKDMLLELEEQLAES---RRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEM 375
++ T+K+ +E+LA S R++ EEK +EK+ LQ Q E L EE
Sbjct: 852 EMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND---LQLQVQSETENLMDAEER 908
Query: 376 LEEIRQLQQKQASSIREISD-LQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVML 434
E + + + + ++E+++ L+E E + + ++ S++ + DDL E+ +
Sbjct: 909 CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL--ELTLT 966
Query: 435 KEELKKHGI-----ILNSEIATNGETSD--TLNNVGYQGPTKMTKEELNALKSTGDGTLD 487
K E +KH L+ E+ E T Q + T ++L + +G +
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026
Query: 488 I--RLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTD-MHVMDLQRD 544
I +L++ D+ E LEQ KKL+ LE ++ + D S++ +++ D + + +
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK 1086
Query: 545 ANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRE 604
++S L+ K+ + ++ + L++++ + E + +++ ++ L RE
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 605 LRSALDKTEELEVSNGHLVKRLEKMKA 631
L ++ EE + ++ +K +A
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREA 1173
Score = 68.2 bits (165), Expect = 2e-11
Identities = 103/423 (24%), Positives = 180/423 (42%), Gaps = 55/423 (13%)
Query: 264 IKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTL 323
++E L Q+ + Q L+E+K + E E K K AM Q + D L
Sbjct: 1295 VEEKESLISQLTKSKQALTQQLEELKRQMEE-ETKAKNAMAHALQSSR------HDCDLL 1347
Query: 324 KDMLLELEEQLAESRRQYEEKNKEFE--REKHAHSILQF--QFAEVKEALKQREEMLEEI 379
++ E +E AE +R + N E R K+ +Q + E K+ L QR + EE
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 380 RQLQQKQASSIR--------EISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV 431
+ + +S+ E+ DL +E L++++ FD V +E +E
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467
Query: 432 VMLKEELKKHGIILNSEIA----TNGETSDTLNNVGYQGPTKMTKEELNALKS----TGD 483
E +K L++E+ E D L + + K +EE++ L TG
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRREN--KNLQEEISDLTEQIAETGK 1525
Query: 484 GTLDI-RLKKLVDERECLLE-QIKKLKGQLE-ERQKIGK----LDNLRSEDDVLENGTDM 536
+ + KKLV++ + L+ +++++G LE E KI + L ++SE D D
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 537 HVMDLQRDANRQISDLKFKL---AKSEQEITALEQNV--------IRLESQVSRYKSAAE 585
+ L+R++ R L+ L +S + L++ + I+L + +
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645
Query: 586 NAEKIEDELKAEKRKLQRELRSALDKTEEL---EVSNGHLVKRLEKMK-----ANRSALL 637
+ ++ +LK + L LRS D E+L E NG L++ LE+MK R+ L
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRL 1705
Query: 638 SQQ 640
S+Q
Sbjct: 1706 SEQ 1708
Score = 66.2 bits (160), Expect = 9e-11
Identities = 83/398 (20%), Positives = 171/398 (42%), Gaps = 80/398 (20%)
Query: 266 ELNELKDQIQDVEG---KYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 322
EL++L+ +I D + ++ + +KE++ + E+EE+ + A+++ ++++ +++
Sbjct: 1090 ELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEE 1149
Query: 323 LKDMLLEL--------------EEQLAESRRQYEEKNKEFE------REKHAHSILQFQF 362
+ + L E E + + RR EE + E R+K A S+ +
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE--- 1206
Query: 363 AEVKEALKQREEMLEEIRQLQQKQASSIR-EISDLQETIEWKDKKIGALERQKEFFDSVR 421
L ++ + L+ ++Q +K+ S ++ EI D+ IE K +ER +
Sbjct: 1207 ------LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 422 SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKST 481
SE E+ L +L L ++ NGE S + KE L
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQ---NGELSHRVEE----------KESL------ 1301
Query: 482 GDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDL 541
+ +L ++ L +Q+++LK Q+EE K + M
Sbjct: 1302 --------ISQLTKSKQALTQQLEELKRQMEEETKA------------------KNAMAH 1335
Query: 542 QRDANRQISDLKFKLAKSEQEITA-LEQNVIRLESQVSRYKSAAE-NAEKIEDELKAEKR 599
++R DL + + EQE A L++ + + S+V+++++ E +A + +EL+ K+
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 600 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALL 637
KL + L+ A + TE L K ++++ L+
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Score = 59.3 bits (142), Expect = 1e-08
Identities = 79/399 (19%), Positives = 168/399 (42%), Gaps = 25/399 (6%)
Query: 262 REIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD 321
R+I +L +++ + +K + + + +EE K L + +
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 322 TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEI-- 379
+D + L + A+ +Q ++ E+EK + L+ +++ LK +E + ++
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 380 --RQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV---ML 434
+Q+++K E+S LQ I+ D+++ +L+ QK+ +++ ++L EE+ L
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKID--DEQVHSLQFQKK-IKELQARIEELEEEIEAEHTL 1132
Query: 435 KEELKKHGIILNSEI--------ATNGETSDTLN-NVGYQGPTKMTKEELNALKSTGDGT 485
+ +++K L E+ +G TS + N + + + +L + T
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 486 LDIRLKKLVDERECLLEQI---KKLKGQLEERQKIGK--LDNLRSEDDVLENGTDMHVMD 540
KK D L EQI +++K +LE+ + K +D++ S + L + ++
Sbjct: 1193 AATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSK-SKSNIER 1251
Query: 541 LQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRK 600
R Q S++K K + Q I L RL++Q E E + +L K+
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQA 1311
Query: 601 LQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
L ++L + EE + + L+ + + L Q
Sbjct: 1312 LTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Score = 54.3 bits (129), Expect = 3e-07
Identities = 63/275 (22%), Positives = 124/275 (45%), Gaps = 33/275 (12%)
Query: 367 EALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDD 426
EA K+ M E+ + +++ A S +L+E K + L+ + + V+SE ++
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEE------KMVSLLQEKNDLQLQVQSETEN 901
Query: 427 LREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTL 486
L + E L K I+L +++ E ++ L +EE+N+ L
Sbjct: 902 LMDAEERC-EGLIKSKILLEAKVK---ELTERLEE----------EEEMNSELVAKKRNL 947
Query: 487 DIR---LKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQ- 542
+ + LK+ +D+ E L +++K K E + K NL E LE + +
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVK-----NLSEEMTALEENISKLTKEKKS 1002
Query: 543 -RDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKL 601
++A++Q D L E ++ L + +LE Q + + E +K+ +L+ KRKL
Sbjct: 1003 LQEAHQQTLD---DLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059
Query: 602 QRELRSALDKTEELEVSNGHLVKRLEKMKANRSAL 636
+ +L+ + + +LE + ++L+K + S L
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL 1094
Score = 38.5 bits (88), Expect = 0.019
Identities = 33/147 (22%), Positives = 68/147 (46%), Gaps = 3/147 (2%)
Query: 269 ELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLL 328
E+++ IQ+ + K + D+ A + E+ KK ++A L+ K N V L+ L
Sbjct: 1744 EVENSIQESRNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802
Query: 329 ELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQAS 388
E E+ + ++ +K + RE + L + EALK + +++++ +
Sbjct: 1803 EAEQLALKGGKKQIQKLENRVRE--LENELDVEQKRGAEALKGAHKYERKVKEMTYQAEE 1860
Query: 389 SIREISDLQETIEWKDKKIGALERQKE 415
+ I LQ+ ++ K+ + +RQ E
Sbjct: 1861 DHKNILRLQDLVDKLQAKVKSYKRQAE 1887
Score = 30.8 bits (68), Expect = 4.0
Identities = 20/116 (17%), Positives = 54/116 (46%), Gaps = 4/116 (3%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 324
K++ +L+++++++E + K ++L + +K Q + + N + L+
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL----RLQ 1869
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
D++ +L+ ++ +RQ EE ++ + +Q + E E E + ++R
Sbjct: 1870 DLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 71.2 bits (173), Expect = 3e-12
Identities = 96/397 (24%), Positives = 179/397 (45%), Gaps = 55/397 (13%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK-----KAMVSNAQLDNEKTNFMYQV 320
E+++LKD + E K K++++ ++ +K K K V + Q D T+
Sbjct: 530 EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD----- 584
Query: 321 DTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIR 380
L LEE LAE R E ++ +R++ Q + K+ LK +E + ++
Sbjct: 585 ----TALTTLEEALAEKERTIERLKEQRDRDEREK---QEEIDNYKKDLKDLKEKVSLLQ 637
Query: 381 -QLQQKQASSI---REISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKE 436
L +K+AS + S L + KD ++ LE E +EE + ++
Sbjct: 638 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALE----------QKKEECLKMES 687
Query: 437 ELKK-HGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVD 495
+LKK H L E + E SD + ++ + K+E + ++ D L+I LK++ +
Sbjct: 688 QLKKAHEAAL--EARASPEMSDRIQHL--EREITRYKDESSKAQAEVDRLLEI-LKEVEN 742
Query: 496 ERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQR------DANRQI 549
E+ ++I +L+ Q++++ K K+ NL+ ++ V + + + + +R D+++Q+
Sbjct: 743 EKNDKDKKIAELERQVKDQNK--KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 800
Query: 550 SDLKFKLAKSEQEITALE-------QNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQ 602
D L K + I LE Q E +++ +SA NAEK +EL K++
Sbjct: 801 QD---SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 857
Query: 603 RELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+EL S K + S L ++A R L +
Sbjct: 858 QELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE 894
Score = 61.2 bits (147), Expect = 3e-09
Identities = 86/368 (23%), Positives = 142/368 (38%), Gaps = 58/368 (15%)
Query: 293 AEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK------DMLLELEEQLAESRRQYEEKNK 346
AE E + K+ + L+ + Q TL LLE+ + S + EE ++
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 347 EFER----EKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEW 402
R E H H + + KE REEM + A + LQ IE
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF-----ENAPDSAKTKALQTVIEM 386
Query: 403 KDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV 462
KD KI ++ER DL EE+ MLK N ++T +
Sbjct: 387 KDSKISSMERGLR----------DLEEEIQMLKS---------NGALSTEEREEEMKQME 427
Query: 463 GYQGPTKMTKEELNAL------KSTGDGTLDIRLKKLVDERECLLEQIKKLKGQL---EE 513
Y+ +K K ++ + K T L +L+ L ++ + I+ LK L E+
Sbjct: 428 VYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 487
Query: 514 RQKI--GKLDNLR---SEDDVLENGTDMHVMDLQRDANRQ---ISDLKFKLAKSEQEITA 565
R I ++D LR E + + N + D+ + Q I DLK L E+++
Sbjct: 488 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 547
Query: 566 LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
L++ + L+ Q+ + EK LK + LQ + + LE + +
Sbjct: 548 LQKKIENLQEQL-------RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 600
Query: 626 LEKMKANR 633
+E++K R
Sbjct: 601 IERLKEQR 608
Score = 60.5 bits (145), Expect = 5e-09
Identities = 88/399 (22%), Positives = 168/399 (42%), Gaps = 79/399 (19%)
Query: 218 KDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDV 277
KD EK S LS + L + + D+ EI L + K++ +
Sbjct: 627 KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA-LEQKKEECLKM 685
Query: 278 EGKYMQGLKEMKDSLA--EVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQ-- 333
E + + + ++ A E+ ++ + + +E + +VD L ++L E+E +
Sbjct: 686 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 745
Query: 334 -----LAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQAS 388
+AE RQ +++NK+ KH + + + A++ E ++RE+ L + Q
Sbjct: 746 DKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ------- 798
Query: 389 SIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSE 448
LQ+++ KD +I LE + +ER E+V+ +EE +
Sbjct: 799 ------QLQDSLRKKDDRIEELEEALRESVQITAER-----EMVLAQEESAR-------- 839
Query: 449 IATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLK 508
TN E K +E L A ++K+ E E + ++ +
Sbjct: 840 --TNAE--------------KQVEELLMA------------MEKVKQELESMKAKLSSTQ 871
Query: 509 GQLEERQKIGKLDNLRSE-----DDVLENGTDMHVMDL-QRDANRQISDLKFKLAKSEQE 562
L E++ L NLR+E ++VLE + + + ++DAN + +L K+++E
Sbjct: 872 QSLAEKET--HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE 929
Query: 563 ITALEQNVIRLESQV-----SRYKSAAENAEKIEDELKA 596
+ AL++ RL Q+ +R K A+N E +D K+
Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMADNYE--DDHFKS 966
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 70.9 bits (172), Expect = 3e-12
Identities = 99/430 (23%), Positives = 191/430 (44%), Gaps = 91/430 (21%)
Query: 266 ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYK----------KAMVSNAQLDNEKTN 315
EL LKDQ+ D+ ++ KE K +L + + + + + ++ Q E T+
Sbjct: 2313 ELKSLKDQLTDLSNS-LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371
Query: 316 FMYQVDTLKDM----LLELEEQ-----LAESRRQYEEKNKEFE----REKHAHSILQFQF 362
+++ +K+ LL +E+ +AE R+Q++++ KE E +E+ + +L+ +
Sbjct: 2372 RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN 2431
Query: 363 AEVKEALKQREEMLEEIRQ--LQQKQA--SSIREISDLQETIEWKDKKIGALERQKEFFD 418
+ + Q E L+ I++ +QQK S ++ +S LQ +D+ +G ++ +E
Sbjct: 2432 KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND---RDRIVGDYQQLEERHL 2488
Query: 419 SVRSERDDLREEVVM----LKEE---LKKHGIILNSEIATNGETSDTLNNVGYQGPTKMT 471
S+ E+D L +E LKEE L+ H LNSE N
Sbjct: 2489 SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE------------NAKLDAELIQY 2536
Query: 472 KEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE 531
+E+LN + + D L+ + + + L + KL+ +L+E ++ ++LR + L+
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN--EDLRRSFNALQ 2594
Query: 532 NGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL----------------EQNVIRL-- 573
+ ++D +++I LK +++ +++TAL E+ V RL
Sbjct: 2595 --------EEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646
Query: 574 -------------ESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNG 620
E V K AA+ +IED+LK E + L + ++TE E
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVA 2706
Query: 621 HLVKRLEKMK 630
L + L +M+
Sbjct: 2707 ELARDLVEME 2716
Score = 69.7 bits (169), Expect = 8e-12
Identities = 125/659 (18%), Positives = 263/659 (39%), Gaps = 87/659 (13%)
Query: 17 ERLTAEDDALNQIAREAEARLAAKRAA--RAEAREIRMKELERQQKEIYQVQKKYYGLDT 74
E++ A + Q+ ++ + L +++A +A+ +E ++E +QQK+ Y +
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ------- 1216
Query: 75 KWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGSLRSQ-PDLEYGGPYAWTNGYD 133
E++ +S+ N + D+ ++ + R S+ + P + + T G +
Sbjct: 1217 ------------EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE 1264
Query: 134 GELYGSQSLNRRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHL 193
L+ + + PS S AS L +G TS ++ ++
Sbjct: 1265 EPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL---------QGGTSVAQIKAQLKEIE 1315
Query: 194 NSSSRASSRASSARASPVVEERPEKDFTEKGSRNMPGLSAATL------ASLGGTSSRRG 247
+ SS + + ++ E+ F + N GL +L A + S ++
Sbjct: 1316 AEKVELELKVSSTTSE--LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQK 1373
Query: 248 SGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNA 307
+ + I A + ++EL D++Q + K + + + L+E E K
Sbjct: 1374 LESSQLQI---AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 308 QLDNE----KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFA 363
+ ++ T Q + + +L+ +L E +++ EE +E ++ LQ
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALI 1490
Query: 364 EVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSE 423
KEALK+ + + E E+S + TIE K + +E Q + E
Sbjct: 1491 SRKEALKENKSLQE--------------ELSLARGTIERLTKSLADVESQ---VSAQNKE 1533
Query: 424 RDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNN--VGYQGPT----KMTK--EEL 475
+D + + +L+EE K ++ + N S + + + +G T K+ K E L
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 476 NALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLE---N 532
+ K + K+L E E LL+ + + + E Q + ++ +R E L
Sbjct: 1594 KSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHV--VEAVRQEKQELYGKLR 1651
Query: 533 GTDMHVMDLQR---DANRQISDLKFKLAK----SEQEITALEQNVIRLESQV----SRYK 581
T+ + + ++ +A +++ ++K K+ K +Q+I LE+ RL ++V K
Sbjct: 1652 STEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAK 1711
Query: 582 SAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
E +K E +++ E + K + L L + ++ +K +S+Q
Sbjct: 1712 ECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ 1770
Score = 65.5 bits (158), Expect = 1e-10
Identities = 100/491 (20%), Positives = 215/491 (43%), Gaps = 86/491 (17%)
Query: 217 EKDFTEKGSRNMPG-------LSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE 269
+ + TE+G++++PG LS +T + + S + ++S D +
Sbjct: 1782 QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH--------- 1832
Query: 270 LKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLE 329
D+I + Y+Q + ++K+ +A +EE+ +K + L+NEK + Q+ T L
Sbjct: 1833 --DEINN----YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKM 1886
Query: 330 LEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEAL-KQREEMLEEI--------- 379
L+E++ + ++ +E R + + +++E L Q E+ I
Sbjct: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD 1946
Query: 380 ----RQLQQKQASSIRE-ISDLQETIEW--KDKKIGALERQKEFFDSVR----------- 421
+L + + ++++ +S+L+E + K+K E +KE+ + ++
Sbjct: 1947 AQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSH 2006
Query: 422 -SERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNV--GYQGPTKMTKEEL-NA 477
E +L +E ++L+K I +I+ T L V Q ++TKE L A
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA 2066
Query: 478 LKSTGDGTLDI-RLKKLVDEREC----LLEQIKKLKGQLEERQKIGKLDNLRSEDDV--- 529
++ ++ K L+D+ + +L KLK +L+ ++ K + ++D+
Sbjct: 2067 VEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 530 LENGTDMHV-----MDLQRDANRQ--------ISDLKFKLAKSEQEITALEQNVIRLESQ 576
LE + H+ M + DA R+ I +++ L K ++E+ L++N+ +Q
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 577 VSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEE---LEVSNGHLVK--------R 625
++ + + + + D + E +K +R+ A+ EE L+ N ++K
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
Query: 626 LEKMKANRSAL 636
+E++K N S L
Sbjct: 2247 MEELKINISRL 2257
Score = 62.0 bits (149), Expect = 2e-09
Identities = 98/480 (20%), Positives = 195/480 (40%), Gaps = 96/480 (20%)
Query: 212 VEERPEKDFTEK--GSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNE 269
VE K++ EK G++ PG + + L + + D +I L
Sbjct: 1982 VESEIRKEYLEKIQGAQKEPG-NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Query: 270 LKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQL-----DNEKTNFMYQVDTLK 324
++ V+ + + L+ K++LA+ E KKA A D + D LK
Sbjct: 2041 TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 384
+ EL+ + Q ++K+++ ER + + AE K LK+++ M E++ L++
Sbjct: 2101 -LKKELQSNKESVKSQMKQKDEDLER--------RLEQAEEKH-LKEKKNMQEKLDALRR 2150
Query: 385 KQASSIREISDLQETIEWKDKKIGALER-------------------------------- 412
++ I ++Q T+ KDK++ L+
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210
Query: 413 -QKEFFDSVRSERDDLR---EEVVMLKEELKKHGIIL---------------------NS 447
+++F D+++S+ +++R + +LK++L++ I + +
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT 2270
Query: 448 EIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKL 507
E+ + DTL QG K +L + + + L KL E + L +Q+ L
Sbjct: 2271 EVQLQQKVCDTL-----QGENKELLSQLEETRHLYHSSQN-ELAKLESELKSLKDQLTDL 2324
Query: 508 KGQLEE-RQKIGKLDNL--RSEDDVLENGTDMHVMDLQRDANRQI-SDLKFKLAKSEQEI 563
LE+ +++ G L+ + + E D+ + ++ A+R++ S L ++ EQ+I
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 564 --------TALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEEL 615
A++ + L Q + EN E+E E L+ E + A+DKT +L
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE---ENIVLEEENKKAVDKTNQL 2441
Score = 61.6 bits (148), Expect = 2e-09
Identities = 87/407 (21%), Positives = 183/407 (44%), Gaps = 60/407 (14%)
Query: 243 SSRRGSGDTSISIDTEASIREIKELN---ELKDQIQDVEGKYMQGLKEMKDSLAEVEEKY 299
+ S T++S + + + ++KEL+ EL+ Q+ K+++ +LAE E +
Sbjct: 732 ADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV-----------KQLEMNLAEAERQR 780
Query: 300 KKAMVSNAQLDNEKTNFMYQVDT---LKDMLLE-LEEQLAESRRQYEEK----------- 344
+ S DN T ++ + KD+ +E L+ +L + + Q+ E+
Sbjct: 781 RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL 840
Query: 345 -NKEFEREKHAHSI--LQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREISDLQETIE 401
NKE E + A + + + E+ +AL Q+E EI ++ Q R++ LQ+TIE
Sbjct: 841 QNKESEVLEGAERVRHISSKVEELSQALSQKEL---EITKMDQLLLEKKRDVETLQQTIE 897
Query: 402 WKDKKIGALE-RQKEFFDSVRSERDDLREEVVMLKEEL---------KKHGIILNSEIAT 451
KD+++ + E + E+ L E+ LKE+L KK + ++E+++
Sbjct: 898 EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSS 957
Query: 452 N-GETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQ 510
+ D ++ G Q + + E + LK + L++ +E LL+++ +L+ +
Sbjct: 958 GLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQRKRKLQAALINRKE-LLQRVSRLEEE 1015
Query: 511 LEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNV 570
L + K + SE E G +++ D + K +K ++ L+Q +
Sbjct: 1016 LANLKDESKKEIPLSE---TERG------EVEEDKENKEYSEKCVTSKCQEIEIYLKQTI 1066
Query: 571 IRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEV 617
E ++ + E E++ +A +++ + L+ DKT ++++
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ---DKTNQIDL 1110
Score = 60.1 bits (144), Expect = 6e-09
Identities = 94/437 (21%), Positives = 186/437 (42%), Gaps = 66/437 (15%)
Query: 251 TSISIDTEASIREIKELN-ELKDQIQDVEGKYMQGLKE-----MKDSLAEVEEKYKKAMV 304
+S+ D + I E K+ + D IQ E + LKE +KD L ++ ++ +
Sbjct: 2195 SSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR--LKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 305 SNAQLDNEK--------TNFMYQ---VDTLKDMLLELEEQLAESRRQYEEKNKEFEREKH 353
+ ++L+++K T Q DTL+ EL QL E+R Y E + +
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 354 AHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSI-----------------REI-SD 395
L+ Q ++ +L++ +E + + ++Q + I RE+ S
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 396 LQETIEWKDKKIGALERQKE-----FFDSVRSERDDLREEVVMLKEELKKHGIILNSE-- 448
L E I K++KI +L KE +R + D +E+ L + ++ I+L E
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432
Query: 449 --IATNGETSDTLN-----NVGYQGPTKMTKEELNALKSTGDGT------LDIRLKKLVD 495
+ + +TL N+ + + +++L++ D L+ R ++
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIIL 2492
Query: 496 ERECLLEQIKKLKGQLEE--RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 553
E++ L+++ +L+E R +D+L SE+ L+ + DL + + S K
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK 2552
Query: 554 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 613
L Q+ LE +LE ++ + A E+ + + L+ EK+ L +E+ E
Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI-------E 2605
Query: 614 ELEVSNGHLVKRLEKMK 630
L+VS L +++ ++
Sbjct: 2606 SLKVSISQLTRQVTALQ 2622
Score = 57.0 bits (136), Expect = 5e-08
Identities = 83/410 (20%), Positives = 161/410 (39%), Gaps = 56/410 (13%)
Query: 265 KELNELKDQIQDVEGKYMQGLKEMKDS---LAEVEEKYKKAMVSNAQ----LDNEKTNFM 317
+E EL +++ E + K+++++ + E++EK +K S Q L+ E
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLR 1700
Query: 318 YQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE 377
+V D E E L S +E E ER K + L +F + + +++ + E
Sbjct: 1701 AEVHPAGDTAKECMETLLSSNASMKE---ELERVKMEYETLSKKFQSL---MSEKDSLSE 1754
Query: 378 EIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEE 437
E++ L+ + ++ + ++L+ T E D + E + E+D L E
Sbjct: 1755 EVQDLKHQIEGNVSKQANLEAT-EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 438 LKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDER 497
N ++ + + D +NN Y KE + L+ + + L +E+
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINN--YLQQIDQLKERIAGLEEEKQKNKEFS-QTLENEK 1870
Query: 498 ECLLEQIKKLKGQL----EERQKIGKLDNLRSED----DVLENGTDMHVMDLQRDANRQI 549
LL QI G+L EE K+ L+ E+ L+ + DL+ Q+
Sbjct: 1871 NTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQL 1930
Query: 550 SDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAE-----------KIEDELKAE- 597
++L + Q++T + LES++ K E K+E E++ E
Sbjct: 1931 AELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY 1990
Query: 598 ----------------KRKLQRELRSALDKTEELEVSNGHLVKRLEKMKA 631
++LQ L+ +K +E++ ++ EK+ A
Sbjct: 1991 LEKIQGAQKEPGNKSHAKELQELLK---EKQQEVKQLQKDCIRYQEKISA 2037
Score = 55.8 bits (133), Expect = 1e-07
Identities = 85/420 (20%), Positives = 172/420 (40%), Gaps = 73/420 (17%)
Query: 282 MQGLKEMKDSLAEVEEKYKKAM----VSNAQLDNEKTNFMYQVDTLKDMLLELE----EQ 333
+Q + +++ LA ++++ KK + +++ +K N Y + E+E +
Sbjct: 1006 LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 334 LAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE-------EIRQLQQKQ 386
++E + + K+ E + A Q ++ + L+ + ++ E + + QK
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL 1125
Query: 387 ASSIREISD------LQETI-----------EWK---DKKIGALERQKEFFDSVRSERDD 426
+S + SD ++ET+ WK ++KI ALE++KE E
Sbjct: 1126 ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
Query: 427 LREEVVM--------LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNAL 478
R+ ++ L+EELK+ N E S N+G ++L L
Sbjct: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG---------DQLRQL 1236
Query: 479 KSTGDGTLDIRLKKLVDEREC-----LLEQIKKLKGQLEERQKIGKLDNL------RSED 527
+ ++D +L + C L E + K Q + + NL SED
Sbjct: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLE--SNLCPDWPSHSED 1294
Query: 528 -DVLENGTDMHVMDLQ-RDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAE 585
L+ GT + + Q ++ + +L+ K++ + E+T + V +L+ Q+++ E
Sbjct: 1295 ASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIE 1354
Query: 586 NAEKIEDELKAEKRKLQRELRSA------LDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
+ + + E + LQ++L S+ L+ EL+ L K + K + + S L Q
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/372 (20%), Positives = 160/372 (43%), Gaps = 43/372 (11%)
Query: 256 DTEASIREIK-ELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKT 314
D I +K +++L Q+ ++ + GL + + E E A+ S++Q
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK----- 2653
Query: 315 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 374
++ L++ L+ ++++ A+ + E+K K+ KH H E + A ++ E
Sbjct: 2654 ----RIAELEEELVCVQKEAAKKVGEIEDKLKK--ELKHLHHDAGIMRNETETAEERVAE 2707
Query: 375 MLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEV-VM 433
+ ++ +++QK +E L I+ + + +L+ + D E D+L+ +
Sbjct: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSR---DHANEELDELKRKYDAS 2764
Query: 434 LKE--ELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTK---------EELNALKSTG 482
LKE +LK+ G++ A ET+ ++N+ + + K E+L L S
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Query: 483 DG------TLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDM 536
+ + + L +ER+ L +++K + E +Q+ S
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQP---STSPAEVQSLKK 2881
Query: 537 HVMDLQRDANRQISDLK---FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDE 593
+ LQ D +R + +LK + + QEIT L L++Q+ Y+ + + +++E
Sbjct: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP----LKAQLQEYQDKTKAFQIMQEE 2937
Query: 594 LKAEKRKLQREL 605
L+ E Q EL
Sbjct: 2938 LRQENLSWQHEL 2949
Score = 49.3 bits (116), Expect = 1e-05
Identities = 100/463 (21%), Positives = 187/463 (40%), Gaps = 58/463 (12%)
Query: 210 PVVEERPEKDFTEKGSRNMPGLSAATLASLG-GTSSRRGSGDTSISIDTEASIREIKELN 268
P VE+ E+ TE SR +S L G S + GD S+S + EL
Sbjct: 633 PAVEK--EQASTEHQSRTSEEIS---LNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
Query: 269 ELKDQIQDVEGK-------YMQGLKEMKDSLAEVE---EKYKKAMVSNAQ----LDNEKT 314
LK QI ++E Y + L E ++ + E++KK +N+ L E+
Sbjct: 688 RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
Query: 315 NFMYQVDTL------KDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 368
+ QV L + + +LE LAE+ RQ + ++E + ++L Q +
Sbjct: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAERQ---RRLDYESQTAHDNLLTEQIHSLSIE 804
Query: 369 LKQREEMLEEIR------QLQQKQASSIREISDLQETIEWKDKKI--GALERQKEFFDSV 420
K ++ +E ++ QLQ + S++ I LQ ++ K+ ++ GA ER + V
Sbjct: 805 AKSKDVKIEVLQNELDDVQLQFSEQSTL--IRSLQSQLQNKESEVLEGA-ERVRHISSKV 861
Query: 421 RSERDDLRE---EVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA 477
L + E+ + + L + + + T E + + + KM +LN
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMV--QLNE 919
Query: 478 LKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMH 537
K + L + +K L ++ L + K Q+EE ++ L+ D + +
Sbjct: 920 EKFS----LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSS--GLKQNYDEMSPAGQIS 973
Query: 538 VMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAE 597
+LQ + DL K ++EQ L+ +I + + R E ++DE K E
Sbjct: 974 KEELQHEF-----DLLKK--ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 598 KRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
+ E + E E S + + ++++ +S++
Sbjct: 1027 IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK 1069
Score = 49.3 bits (116), Expect = 1e-05
Identities = 75/363 (20%), Positives = 157/363 (43%), Gaps = 48/363 (13%)
Query: 262 REIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVD 321
+E+K L+ +++ + + E+ L E+E+K N L + +F +
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 322 TLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEAL----KQREEMLE 377
+L++ E+L E +R+Y+ KE + K + + + A + E E L
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS 2801
Query: 378 EIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLK-- 435
+ +L Q+ S ++ L +E ++ + + S+++ERD L E+ +
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA---MASLQNERDHLWNELEKFRKS 2858
Query: 436 EELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVD 495
EE K+ A TS E+ +LK + L +
Sbjct: 2859 EEGKQRS-------AAQPSTSPA---------------EVQSLKKA--------MSSLQN 2888
Query: 496 ERECLLEQIKKLKGQ-LEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKF 554
+R+ LL+++K L+ Q L+ Q+I +L L+++ ++ T + +Q + ++ +
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI-MQEELRQENLSWQH 2947
Query: 555 KLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEE 614
+L + E ++ E + R++ Q Y A + +D+ + + L RELRS+ +T+
Sbjct: 2948 ELHQLRMEKSSWEIHERRMKEQ---YLMAISD----KDQQLSHLQNLIRELRSSSSQTQP 3000
Query: 615 LEV 617
L+V
Sbjct: 3001 LKV 3003
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/396 (21%), Positives = 164/396 (41%), Gaps = 47/396 (11%)
Query: 269 ELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKK----AMVSNAQLDNEKTNFMYQVDTLK 324
ELKD I+ + + Q + +++ + K KK A L+ Q T+
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVL 122
Query: 325 DMLLELEEQLAESRRQYEEKNKEFEREKH-------AHSILQFQFAEVK-----EALKQR 372
+ EEQL++ + E+ E E+ KH S LQ Q + + ++ +
Sbjct: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM 182
Query: 373 EEMLEEIRQLQQKQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVV 432
EE + +QLQ+K+ + L +T + + E+ F VR D+L + V
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVT 242
Query: 433 M--LKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRL 490
++ E+++ +L ++ + E+ VG + ++EL A + R
Sbjct: 243 QADVETEMQQKLRVLQRKLEEHEESL-----VGRAQVVDLLQQELTAAEQ--------RN 289
Query: 491 KKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDAN---R 547
+ L + + + + L+ +E ++ K+ + E +V E H +LQ + +
Sbjct: 290 QILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH--NLQEEMHHLLE 347
Query: 548 QISDLKFKLAKSEQEITALEQ-NVIRLESQVSRYKSAAENAEKIE---DELKAEKRKLQR 603
Q A+ E +ALEQ + +E + S S + ++++ D LK + KL +
Sbjct: 348 QFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ 407
Query: 604 ELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQ 639
DK E+ V + +++LE +S +SQ
Sbjct: 408 ------DKNEQ-AVQSAQTIQQLEDQLQQKSKEISQ 436
Score = 43.5 bits (101), Expect = 6e-04
Identities = 74/381 (19%), Positives = 173/381 (45%), Gaps = 46/381 (12%)
Query: 250 DTSISIDTEASIREIKELN-ELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 308
D ++ + +A+ +IK+L K ++ + KY++ +K ++ E + ++ + +
Sbjct: 79 DEALQEERKAADNKIKKLKLHAKAKLTSLN-KYIEEMKAQGGTVLPTEPQSEEQLSKH-- 135
Query: 309 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQ-FAEVKE 367
D T +++ +K L E EE ++ + Q + + E+ A S + + F +K+
Sbjct: 136 -DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA----QAEQPAQSSTEMEEFVMMKQ 190
Query: 368 ALKQREEMLEEIR-QLQQKQASSIREISDLQETIEWKDKKIGALER--QKEFFDSVRSE- 423
L+++EE + ++ QL Q QA Q+ + KD + R + E V
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAEQAA-----QQVVREKDARFETQVRLHEDELLQLVTQAD 245
Query: 424 -RDDLREEVVMLKEELKKH-----GIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNA 477
++++++ +L+ +L++H G ++ T+ N + + E N
Sbjct: 246 VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
Query: 478 LKSTGDGTLD---IRLKKL---VDERECLLEQIKK-LKGQLEERQKIGKLD-NLRSEDDV 529
L++T + + I L+K+ V ER+ +++ + LE+ ++ G+ L S
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365
Query: 530 LENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL-----EQNVIRLESQVSRYKSAA 584
LE H +++ + +S L K+ QE+ + +QN L+ + + +A
Sbjct: 366 LEQ---KHKAEMEEKTSHILS-----LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSA 417
Query: 585 ENAEKIEDELKAEKRKLQREL 605
+ +++ED+L+ + +++ + L
Sbjct: 418 QTIQQLEDQLQQKSKEISQFL 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,634,209
Number of Sequences: 37866
Number of extensions: 1024033
Number of successful extensions: 14625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 385
Number of HSP's successfully gapped in prelim test: 1057
Number of HSP's that attempted gapping in prelim test: 6429
Number of HSP's gapped (non-prelim): 5426
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.