BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein [Homo sapiens] (396 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 797 0.0 gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 761 0.0 gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 655 0.0 gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 374 e-104 gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 326 2e-89 gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 306 2e-83 gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 189 5e-48 gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 119 6e-27 gi|4503143 cathepsin D preproprotein [Homo sapiens] 96 4e-20 gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 96 6e-20 gi|119372302 pepsinogen 4, group I [Homo sapiens] 94 2e-19 gi|119372298 pepsinogen 3, group I [Homo sapiens] 94 2e-19 gi|23943854 pepsinogen 5, group I [Homo sapiens] 94 2e-19 gi|4506475 renin preproprotein [Homo sapiens] 92 6e-19 gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 79 5e-15 gi|4758754 napsin A preproprotein [Homo sapiens] 77 3e-14 gi|39995080 hypothetical protein LOC79567 [Homo sapiens] 33 0.45 gi|197927448 WD repeat domain 6 protein [Homo sapiens] 33 0.45 gi|38683860 insulin receptor substrate 2 [Homo sapiens] 33 0.59 gi|19924099 synapsin I isoform Ia [Homo sapiens] 33 0.59 gi|19924097 synapsin I isoform Ib [Homo sapiens] 33 0.59 gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 32 0.77 gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 32 0.77 gi|239753114 PREDICTED: hypothetical protein [Homo sapiens] 32 1.0 gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 32 1.0 gi|124378039 SEC16 homolog A [Homo sapiens] 31 1.7 gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 31 1.7 gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Hom... 30 3.8 gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Hom... 30 3.8 gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo ... 30 3.8 >gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein [Homo sapiens] Length = 396 Score = 797 bits (2058), Expect = 0.0 Identities = 396/396 (100%), Positives = 396/396 (100%) Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI 360 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI 360 Query: 361 YLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM 396 YLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM Sbjct: 361 YLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM 396 >gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein [Homo sapiens] Length = 518 Score = 761 bits (1966), Expect = 0.0 Identities = 378/378 (100%), Positives = 378/378 (100%) Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI 360 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI 360 Query: 361 YLRDENSSRSFRITILPQ 378 YLRDENSSRSFRITILPQ Sbjct: 361 YLRDENSSRSFRITILPQ 378 >gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein [Homo sapiens] Length = 468 Score = 655 bits (1691), Expect = 0.0 Identities = 328/329 (99%), Positives = 329/329 (100%) Query: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL Sbjct: 1 MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL 60 Query: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG Sbjct: 61 ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG 120 Query: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI Sbjct: 121 TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI 180 Query: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA Sbjct: 181 FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA 240 Query: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA Sbjct: 241 GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA 300 Query: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLI 329 IVDSGTTLLRLPQKVFDAVVEAVARASL+ Sbjct: 301 IVDSGTTLLRLPQKVFDAVVEAVARASLL 329 >gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein [Homo sapiens] Length = 501 Score = 374 bits (960), Expect = e-104 Identities = 176/312 (56%), Positives = 227/312 (72%), Gaps = 3/312 (0%) Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130 P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+ Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113 Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190 + SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173 Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247 W GILGLAYA +A+P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG Sbjct: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 233 Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307 S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT Sbjct: 234 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 293 Query: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367 LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E + Sbjct: 294 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 353 Query: 368 SRSFRITILPQK 379 ++SFRITILPQ+ Sbjct: 354 NQSFRITILPQQ 365 >gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein [Homo sapiens] Length = 476 Score = 326 bits (836), Expect = 2e-89 Identities = 160/312 (51%), Positives = 207/312 (66%), Gaps = 28/312 (8%) Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130 P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+ Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113 Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190 + SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173 Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247 W GILGLAYA +A+ +CGAG P+ S + GG Sbjct: 174 SNWEGILGLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGG 208 Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307 S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT Sbjct: 209 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 268 Query: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367 LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E + Sbjct: 269 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 328 Query: 368 SRSFRITILPQK 379 ++SFRITILPQ+ Sbjct: 329 NQSFRITILPQQ 340 >gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein [Homo sapiens] Length = 457 Score = 306 bits (784), Expect = 2e-83 Identities = 152/312 (48%), Positives = 197/312 (63%), Gaps = 47/312 (15%) Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130 P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+ Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113 Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190 + SSTYR V V YTQG W G +G DL Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDL---------------------------- 145 Query: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247 P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG Sbjct: 146 ----------------PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 189 Query: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307 S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT Sbjct: 190 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 249 Query: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367 LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E + Sbjct: 250 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 309 Query: 368 SRSFRITILPQK 379 ++SFRITILPQ+ Sbjct: 310 NQSFRITILPQQ 321 >gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein [Homo sapiens] Length = 432 Score = 189 bits (479), Expect = 5e-48 Identities = 85/151 (56%), Positives = 114/151 (75%), Gaps = 3/151 (1%) Query: 232 MCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSL 288 +CGAG P+ S + GGS+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L Sbjct: 146 LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL 205 Query: 289 NLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNS 348 +DC+EYN DK+IVDSGTT LRLP+KVF+A V+++ AS +F DGFW G QL CW Sbjct: 206 KMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG 265 Query: 349 ETPWSYFPKISIYLRDENSSRSFRITILPQK 379 TPW+ FP IS+YL E +++SFRITILPQ+ Sbjct: 266 TTPWNIFPVISLYLMGEVTNQSFRITILPQQ 296 Score = 109 bits (273), Expect = 4e-24 Identities = 51/93 (54%), Positives = 64/93 (68%) Query: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130 P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+ Sbjct: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113 Query: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLV 163 + SSTYR V V YTQG W G +G DL+ Sbjct: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLL 146 >gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] Length = 388 Score = 119 bits (297), Expect = 6e-27 Identities = 84/240 (35%), Positives = 131/240 (54%), Gaps = 26/240 (10%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAV--------AGTPHSYIDTYFDTERSSTYRSKGF 143 Y+ E+ IGTPPQ +L DTGSSN V A T HS F+ SSTY + G Sbjct: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSR----FNPSESSTYSTNGQ 128 Query: 144 DVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYAT 203 +++Y GS TGF G D +T+ + ++ NF +++GI+GLAY Sbjct: 129 TFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYA--QFDGIMGLAYPA 186 Query: 204 LAKPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGD 262 L+ ++ T +V + + + VFS+ + G++GG++V GG++ SLY G Sbjct: 187 LSVDEAT--TAMQGMVQEGALTSPVFSVYLSNQ------QGSSGGAVVFGGVDSSLYTGQ 238 Query: 263 IWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEA 322 I++ P+ +E Y+QI I + IGGQ+ C E +AIVD+GT+LL +PQ+ A+++A Sbjct: 239 IYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSALLQA 295 >gi|4503143 cathepsin D preproprotein [Homo sapiens] Length = 412 Score = 96.3 bits (238), Expect = 4e-20 Identities = 79/254 (31%), Positives = 128/254 (50%), Gaps = 27/254 (10%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTY------FDTERSSTYRSKGFDV 145 YY E+ IGTPPQ ++ DTGSSN V +D +++++SSTY G Sbjct: 79 YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138 Query: 146 TVKYTQGSWTGFVGEDLVTIP--KGFNTSFL--VNIATIFESENFFLPGI-----KWNGI 196 + Y GS +G++ +D V++P + S L V + E PGI K++GI Sbjct: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198 Query: 197 LGLAYATLAKPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIE 255 LG+AY ++ +++ FD+L+ Q + N+FS L GG L+LGG + Sbjct: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFY-----LSRDPDAQPGGELMLGGTD 251 Query: 256 PSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV 315 YKG + Y + + Y+Q+ + ++E+ L L C+E +AIVD+GT+L+ P Sbjct: 252 SKYYKGSLSYLNVTRKAYWQVHLDQVEV-ASGLTL-CKE--GCEAIVDTGTSLMVGPVDE 307 Query: 316 FDAVVEAVARASLI 329 + +A+ LI Sbjct: 308 VRELQKAIGAVPLI 321 >gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] Length = 396 Score = 95.9 bits (237), Expect = 6e-20 Identities = 69/246 (28%), Positives = 122/246 (49%), Gaps = 16/246 (6%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147 Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++ Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137 Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207 +Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLAV- 194 Query: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267 + FD+++ Q N+ + M + G G L+ GG + S + G + + P Sbjct: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249 Query: 268 IKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS 327 + ++ Y+QI + +++GG + C E +AIVD+GT+L+ P + A+ A Sbjct: 250 VTKQAYWQIALDNIQVGGTV--MFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIGAAP 305 Query: 328 LIPEFS 333 + E++ Sbjct: 306 VDGEYA 311 >gi|119372302 pepsinogen 4, group I [Homo sapiens] Length = 388 Score = 94.4 bits (233), Expect = 2e-19 Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147 Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++ Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135 Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206 Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++ Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191 Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265 SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + + Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243 Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP 312 P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P Sbjct: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGP 286 >gi|119372298 pepsinogen 3, group I [Homo sapiens] Length = 388 Score = 94.4 bits (233), Expect = 2e-19 Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147 Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++ Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135 Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206 Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++ Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191 Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265 SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + + Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243 Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP 312 P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P Sbjct: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGP 286 >gi|23943854 pepsinogen 5, group I [Homo sapiens] Length = 388 Score = 94.4 bits (233), Expect = 2e-19 Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147 Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++ Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135 Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206 Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++ Sbjct: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191 Query: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265 SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + + Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDKSGSVVIFGGIDSSYYTGSLNW 243 Query: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP 312 P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P Sbjct: 244 VPVTVEGYWQITVDSITMNGET--IACAE--GCQAIVDTGTSLLTGP 286 >gi|4506475 renin preproprotein [Homo sapiens] Length = 406 Score = 92.4 bits (228), Expect = 6e-19 Identities = 64/239 (26%), Positives = 126/239 (52%), Gaps = 19/239 (7%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSSTYRSKGFDV 145 YY E+ IGTPPQ +++ DTGSSN V + S + T FD SS+Y+ G ++ Sbjct: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145 Query: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205 T++Y+ G+ +GF+ +D++T+ G + + T + F L +++G++G+ + + Sbjct: 146 TLRYSTGTVSGFLSQDIITV-GGITVTQMFGEVTEMPALPFML--AEFDGVVGMGF--IE 200 Query: 206 KPSSSLETFFDSLVTQANI-PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264 + + FD++++Q + +VFS S + GG +VLGG +P Y+G+ Sbjct: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYY---NRDSENSQSLGGQIVLGGSDPQHYEGNFH 257 Query: 265 YTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAV 323 Y + + +QI++ + +G +L + + A+VD+G + + + ++EA+ Sbjct: 258 YINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYISGSTSSIEKLMEAL 312 >gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] Length = 363 Score = 79.3 bits (194), Expect = 5e-15 Identities = 54/191 (28%), Positives = 94/191 (49%), Gaps = 12/191 (6%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG----TPHSYIDTYFDTERSSTYRSKGFDVTV 147 Y+ + IG+PPQ ++ DTGSSN V +P + F +SSTY G ++ Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137 Query: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKP 207 +Y GS +G +G D V++ +G ++ E F+ +++GILGL Y +LA Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVDA-EFDGILGLGYPSLA-- 193 Query: 208 SSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTP 267 + FD+++ Q N+ + M + G G L+ GG + S + G + + P Sbjct: 194 VGGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVP 249 Query: 268 IKEEWYYQIEI 278 + ++ Y+QI + Sbjct: 250 VTKQAYWQIAL 260 >gi|4758754 napsin A preproprotein [Homo sapiens] Length = 420 Score = 77.0 bits (188), Expect = 3e-14 Identities = 71/246 (28%), Positives = 120/246 (48%), Gaps = 22/246 (8%) Query: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAG------TPHSYIDTYFDTERSSTYRSKGFDV 145 Y+ E+ +GTPPQ + DTGSSN V + ++ FD + SS++++ G Sbjct: 78 YFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKF 137 Query: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205 ++Y G G + ED +TI G + ++ ++E F ++GILGL + L+ Sbjct: 138 AIQYGTGRVDGILSEDKLTIG-GIKGASVIFGEALWEPSLVFAFA-HFDGILGLGFPILS 195 Query: 206 KPSSSLETFFDSLVTQANIPN-VFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264 + D LV Q + VFS L +GG LVLGG +P+ Y + Sbjct: 196 V--EGVRPPMDVLVEQGLLDKPVFSFY-----LNRDPEEPDGGELVLGGSDPAHYIPPLT 248 Query: 265 YTPIKEEWYYQIEILKLEIG-GQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAV 323 + P+ Y+QI + ++++G G +L C + A AI+D+GT+L+ P + A+ A+ Sbjct: 249 FVPVTVPAYWQIHMERVKVGPGLTL---CAKGCA--AILDTGTSLITGPTEEIRALHAAI 303 Query: 324 ARASLI 329 L+ Sbjct: 304 GGIPLL 309 >gi|39995080 hypothetical protein LOC79567 [Homo sapiens] Length = 1219 Score = 33.1 bits (74), Expect = 0.45 Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 11/81 (13%) Query: 22 PELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHAD-GLALALEPALASPAGAANFLAM 80 P +PAP + +T + ++PTP P TPA +H+D LA+A++ + + AG + ++ Sbjct: 736 PLTSPAPDP-----SESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPVPTAAGGSGDRSL 790 Query: 81 VDNLQG-----DSGRGYYLEM 96 + L D RG + E+ Sbjct: 791 EEALGALMAALDDYRGQFPEL 811 >gi|197927448 WD repeat domain 6 protein [Homo sapiens] Length = 1151 Score = 33.1 bits (74), Expect = 0.45 Identities = 29/102 (28%), Positives = 42/102 (41%), Gaps = 17/102 (16%) Query: 225 PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIE-----PSLY----------KGDIWYTPIK 269 P V GAG PV GSG++GG G+ PSL+ G YT + Sbjct: 558 PGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGR 617 Query: 270 EEWYYQIEILKLEIGGQSLNLDCREYN--ADKAIVDSGTTLL 309 + YYQ+ + ++ CR N A IV G+ ++ Sbjct: 618 DGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVI 659 >gi|38683860 insulin receptor substrate 2 [Homo sapiens] Length = 1338 Score = 32.7 bits (73), Expect = 0.59 Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 12/89 (13%) Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAM 80 +PE + LP R +A+ + + P P P P E + L A A A GAA+ Sbjct: 1007 SPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYR--LPPASAVATAQGPGAAS---- 1060 Query: 81 VDNLQGDSG-RGYYLEMLIG---TPPQKL 105 +L D+G G Y EM G TPPQ + Sbjct: 1061 --SLSSDTGDNGDYTEMAFGVAATPPQPI 1087 >gi|19924099 synapsin I isoform Ia [Homo sapiens] Length = 705 Score = 32.7 bits (73), Expect = 0.59 Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 46 TPGPGTPAERHADGLALALEPALASP--AGAANFLAMVDN 83 TPGPGT + G+A A PA SP +G F + + N Sbjct: 43 TPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSN 82 >gi|19924097 synapsin I isoform Ib [Homo sapiens] Length = 669 Score = 32.7 bits (73), Expect = 0.59 Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 46 TPGPGTPAERHADGLALALEPALASP--AGAANFLAMVDN 83 TPGPGT + G+A A PA SP +G F + + N Sbjct: 43 TPGPGTATAERSSGVAPAASPAAPSPGSSGGGGFFSSLSN 82 >gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] Length = 4302 Score = 32.3 bits (72), Expect = 0.77 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 7/84 (8%) Query: 117 AVAGTPHSYIDTY-FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLV 175 A A P Y T+ F TE ++ R++G +VT Y G LVT+ N S Sbjct: 1402 ACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDP------GSYLVTVTASNNISAAN 1455 Query: 176 NIATIFESENFFLPGIKWNGILGL 199 + A + E + IK NG LGL Sbjct: 1456 DSALVEVQEPVLVTSIKVNGSLGL 1479 >gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] Length = 4303 Score = 32.3 bits (72), Expect = 0.77 Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 7/84 (8%) Query: 117 AVAGTPHSYIDTY-FDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLV 175 A A P Y T+ F TE ++ R++G +VT Y G LVT+ N S Sbjct: 1402 ACAWPPFPYRYTWDFGTEEAAPTRARGPEVTFIYRDP------GSYLVTVTASNNISAAN 1455 Query: 176 NIATIFESENFFLPGIKWNGILGL 199 + A + E + IK NG LGL Sbjct: 1456 DSALVEVQEPVLVTSIKVNGSLGL 1479 >gi|239753114 PREDICTED: hypothetical protein [Homo sapiens] Length = 322 Score = 32.0 bits (71), Expect = 1.0 Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 5/45 (11%) Query: 11 PLLAQWLLRAAPELA-----PAPFTLPLRVAAATNRVVAPTPGPG 50 PL+A ++AP L PAP L LR A+ + AP+PG G Sbjct: 204 PLIAPGAHQSAPPLPVLGRLPAPLPLQLRAGGASTGLAAPSPGRG 248 >gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] Length = 538 Score = 32.0 bits (71), Expect = 1.0 Identities = 24/60 (40%), Positives = 26/60 (43%), Gaps = 9/60 (15%) Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAER-------HADGLALALEPALASPAG 73 AP A AP P AAA P+PGP P R A A A PA+A PAG Sbjct: 138 APVAAAAPARAPRAAAAAA--TAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAG 195 >gi|124378039 SEC16 homolog A [Homo sapiens] Length = 2357 Score = 31.2 bits (69), Expect = 1.7 Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 3/71 (4%) Query: 19 RAAPELAPAPFTLPLRVAAATNRVVAPTPG---PGTPAERHADGLALALEPALASPAGAA 75 R+ P LAPA F PL + + PTP P P +G A A A PA Sbjct: 2204 RSEPALAPADFVAPLAPLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEP 2263 Query: 76 NFLAMVDNLQG 86 L+ +L G Sbjct: 2264 KVLSSAASLPG 2274 >gi|167614488 TBC1 domain family, member 10B [Homo sapiens] Length = 808 Score = 31.2 bits (69), Expect = 1.7 Identities = 26/71 (36%), Positives = 34/71 (47%), Gaps = 3/71 (4%) Query: 21 APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHAD-GLALALEPALASPAG-AANFL 78 APE P T P A VV TP P PAE D G +L P ++ P G A + L Sbjct: 209 APEDPSGPGTGPSGTCEAPVAVVTVTPAP-EPAENSQDLGSTSSLGPGISGPRGQAPDTL 267 Query: 79 AMVDNLQGDSG 89 + +D++ SG Sbjct: 268 SYLDSVSLMSG 278 >gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Homo sapiens] Length = 305 Score = 30.0 bits (66), Expect = 3.8 Identities = 25/60 (41%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 17 LLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPG-TPAERHADGLALALEPALA-SPAGA 74 +L AP APAP P+ A V+AP P P PA A A A PA A +PA A Sbjct: 142 VLAPAPAPAPAPVAAPVAAPVAV-AVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPA 200 >gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Homo sapiens] Length = 305 Score = 30.0 bits (66), Expect = 3.8 Identities = 25/60 (41%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 17 LLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPG-TPAERHADGLALALEPALA-SPAGA 74 +L AP APAP P+ A V+AP P P PA A A A PA A +PA A Sbjct: 142 VLAPAPAPAPAPVAAPVAAPVAV-AVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPA 200 >gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo sapiens] Length = 316 Score = 30.0 bits (66), Expect = 3.8 Identities = 25/60 (41%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 17 LLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPG-TPAERHADGLALALEPALA-SPAGA 74 +L AP APAP P+ A V+AP P P PA A A A PA A +PA A Sbjct: 153 VLAPAPAPAPAPVAAPVAAPVAV-AVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPA 211 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.136 0.412 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,919,210 Number of Sequences: 37866 Number of extensions: 796853 Number of successful extensions: 2360 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 26 Number of HSP's successfully gapped in prelim test: 24 Number of HSP's that attempted gapping in prelim test: 2276 Number of HSP's gapped (non-prelim): 74 length of query: 396 length of database: 18,247,518 effective HSP length: 104 effective length of query: 292 effective length of database: 14,309,454 effective search space: 4178360568 effective search space used: 4178360568 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.