BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|205277392 dynactin 1 isoform 3 [Homo sapiens] (1253 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 2411 0.0 gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 2393 0.0 gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 2154 0.0 gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 2148 0.0 gi|4506751 restin isoform a [Homo sapiens] 126 1e-28 gi|38044112 restin isoform b [Homo sapiens] 125 3e-28 gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 110 1e-23 gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 108 3e-23 gi|156104908 myosin heavy chain 6 [Homo sapiens] 106 1e-22 gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 99 2e-20 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 97 7e-20 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 96 2e-19 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 96 2e-19 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 96 2e-19 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 96 2e-19 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 96 2e-19 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 95 5e-19 gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 5e-19 gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 95 5e-19 gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 6e-19 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 94 8e-19 gi|16262452 cingulin [Homo sapiens] 94 1e-18 gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 92 4e-18 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 91 5e-18 gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 91 5e-18 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 91 5e-18 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 91 5e-18 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 91 5e-18 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 91 5e-18 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 91 5e-18 >gi|205277392 dynactin 1 isoform 3 [Homo sapiens] Length = 1253 Score = 2411 bits (6248), Expect = 0.0 Identities = 1253/1253 (100%), Positives = 1253/1253 (100%) Query: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV Sbjct: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60 Query: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE Sbjct: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120 Query: 121 GTDTTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPV 180 GTDTTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPV Sbjct: 121 GTDTTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPV 180 Query: 181 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE 240 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE Sbjct: 181 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQE 240 Query: 241 WKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES 300 WKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES Sbjct: 241 WKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES 300 Query: 301 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL 360 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL Sbjct: 301 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL 360 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV Sbjct: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 Query: 421 EMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQ 480 EMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQ Sbjct: 421 EMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQ 480 Query: 481 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFA 540 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFA Sbjct: 481 KRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFA 540 Query: 541 ETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 600 ETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE Sbjct: 541 ETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 600 Query: 601 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 660 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD Sbjct: 601 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 660 Query: 661 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 720 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE Sbjct: 661 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 720 Query: 721 DCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK 780 DCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK Sbjct: 721 DCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK 780 Query: 781 IRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEG 840 IRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEG Sbjct: 781 IRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEG 840 Query: 841 LLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSK 900 LLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSK Sbjct: 841 LLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSK 900 Query: 901 PPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL 960 PPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL Sbjct: 901 PPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL 960 Query: 961 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ 1020 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ Sbjct: 961 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQ 1020 Query: 1021 SKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHIS 1080 SKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHIS Sbjct: 1021 SKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHIS 1080 Query: 1081 QLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTH 1140 QLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTH Sbjct: 1081 QLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTH 1140 Query: 1141 THVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFAT 1200 THVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFAT Sbjct: 1141 THVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFAT 1200 Query: 1201 FPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253 FPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS Sbjct: 1201 FPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253 >gi|13259510 dynactin 1 isoform 1 [Homo sapiens] Length = 1278 Score = 2393 bits (6201), Expect = 0.0 Identities = 1253/1278 (98%), Positives = 1253/1278 (98%), Gaps = 25/1278 (1%) Query: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV Sbjct: 1 MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV 60 Query: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE Sbjct: 61 ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE 120 Query: 121 GTDTTAKTSKL--------------------PTRPASTGVAGASSSLGPSGSASAGELSS 160 GTDTTAKTSKL PTRPASTGVAGASSSLGPSGSASAGELSS Sbjct: 121 GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS 180 Query: 161 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 220 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE Sbjct: 181 SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE 240 Query: 221 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 280 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT Sbjct: 241 DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT 300 Query: 281 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 340 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL Sbjct: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360 Query: 341 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 400 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE Sbjct: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420 Query: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 460 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE Sbjct: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480 Query: 461 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 520 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA Sbjct: 481 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 540 Query: 521 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 580 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG Sbjct: 541 SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG 600 Query: 581 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 640 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL Sbjct: 601 GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL 660 Query: 641 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 700 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL Sbjct: 661 SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL 720 Query: 701 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 760 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI Sbjct: 721 TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI 780 Query: 761 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 820 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV Sbjct: 781 ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV 840 Query: 821 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 880 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM Sbjct: 841 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 900 Query: 881 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 940 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK Sbjct: 901 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 960 Query: 941 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1000 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ Sbjct: 961 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1020 Query: 1001 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGS 1055 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAG GAIPGQAPGS Sbjct: 1021 ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS 1080 Query: 1056 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1115 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG Sbjct: 1081 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1140 Query: 1116 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1175 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE Sbjct: 1141 SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE 1200 Query: 1176 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1235 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH Sbjct: 1201 KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH 1260 Query: 1236 RLVLTQEQLHQLHSRLIS 1253 RLVLTQEQLHQLHSRLIS Sbjct: 1261 RLVLTQEQLHQLHSRLIS 1278 >gi|205277396 dynactin 1 isoform 4 [Homo sapiens] Length = 1139 Score = 2154 bits (5581), Expect = 0.0 Identities = 1125/1130 (99%), Positives = 1126/1130 (99%), Gaps = 1/1130 (0%) Query: 124 TTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 183 TT + K PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS Sbjct: 11 TTTRRPK-PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 69 Query: 184 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 243 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS Sbjct: 70 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 129 Query: 244 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ Sbjct: 130 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189 Query: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS Sbjct: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249 Query: 364 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML Sbjct: 250 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309 Query: 424 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 483 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV Sbjct: 310 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 369 Query: 484 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 543 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK Sbjct: 370 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 429 Query: 544 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 603 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR Sbjct: 430 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 489 Query: 604 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 663 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK Sbjct: 490 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549 Query: 664 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT Sbjct: 550 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 783 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR Sbjct: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 669 Query: 784 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 843 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV Sbjct: 670 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 729 Query: 844 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 903 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP Sbjct: 730 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 789 Query: 904 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 963 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA Sbjct: 790 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849 Query: 964 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR Sbjct: 850 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909 Query: 1024 TIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQ 1083 TIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQ Sbjct: 910 TIEGLRGPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQ 969 Query: 1084 HENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHV 1143 HENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHV Sbjct: 970 HENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHV 1029 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPS 1203 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPS Sbjct: 1030 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPS 1089 Query: 1204 SAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253 SAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS Sbjct: 1090 SAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1139 >gi|13259508 dynactin 1 isoform 2 [Homo sapiens] Length = 1144 Score = 2148 bits (5565), Expect = 0.0 Identities = 1125/1135 (99%), Positives = 1126/1135 (99%), Gaps = 6/1135 (0%) Query: 124 TTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 183 TT + K PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS Sbjct: 11 TTTRRPK-PTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTS 69 Query: 184 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 243 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS Sbjct: 70 PGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS 129 Query: 244 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ Sbjct: 130 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 189 Query: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS Sbjct: 190 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 249 Query: 364 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML Sbjct: 250 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 309 Query: 424 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 483 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV Sbjct: 310 TDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRV 369 Query: 484 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 543 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK Sbjct: 370 EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETK 429 Query: 544 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 603 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR Sbjct: 430 AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIR 489 Query: 604 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 663 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK Sbjct: 490 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 549 Query: 664 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT Sbjct: 550 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 609 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 783 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR Sbjct: 610 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRR 669 Query: 784 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 843 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV Sbjct: 670 RMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLV 729 Query: 844 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 903 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP Sbjct: 730 AALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPP 789 Query: 904 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 963 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA Sbjct: 790 VELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 849 Query: 964 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR Sbjct: 850 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909 Query: 1024 TIEGLRGPPPSGIATLVSGIAG-----GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 1078 TIEGLRGPPPSGIATLVSGIAG GAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH Sbjct: 910 TIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLH 969 Query: 1079 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1138 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS Sbjct: 970 ISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLS 1029 Query: 1139 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1198 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF Sbjct: 1030 THTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDF 1089 Query: 1199 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1253 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS Sbjct: 1090 ATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS 1144 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 126 bits (316), Expect = 1e-28 Identities = 224/1090 (20%), Positives = 453/1090 (41%), Gaps = 131/1090 (12%) Query: 19 SAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKY 78 S + R L++G RV ++G G V ++G T FA G+W GV LDE GKNDG V G +Y Sbjct: 204 SIKKGERELKIGDRV-LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 262 Query: 79 FTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSA--------SKVLKREGTDTTAKT-- 128 F C +G+F +V + G +T+P ++A S LKR + ++ + Sbjct: 263 FQCQPKYGLFAPVH--KVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMS 320 Query: 129 ---SKLPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTPAQTPLAAPIIPTPVLT 182 S + +RP+ TG+ +SS SG+ + E + Q + V Sbjct: 321 SVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380 Query: 183 SPGAVPPLPSP-SKEEEGLRAQVRDLEEKLETLR-LKRAEDKAK---LKELEKHKIQLEQ 237 + V + + +G V +LE K++ LR + A D+ K L +LE+ K ++E Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440 Query: 238 VQEWKSKMQEQQADL--QRRLKEAR-KEAKEALEAKERYMEEMADTADAIEMATLDKE-- 292 +Q + + DL Q +L+ AR KE +++L ++ +++ + +AT+ ++ Sbjct: 441 LQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500 Query: 293 -MAEERAESLQ-QEVEALKERVD------------ELTTDLEILKAEIEEKGSDGAASSY 338 M E+ +L+ QEV L+ R++ L ++ L+ ++E +D Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560 Query: 339 QLKQ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE-LEVVRQQRERLQ 393 LK+ EE + + AL + S E + L+ +E N+E +V+ + +L+ Sbjct: 561 SLKEHFGAREETHQKEIKALYTATEKLSKENE---SLKSKLEHANKENSDVIALWKSKLE 617 Query: 394 EELSQAESTIDELKEQVDAALGAE-----EMVEMLTDRNLNLEEKVRELR-----ETVGD 443 ++ + ++ELK LG E E+ + L+ + ++ L+ E Sbjct: 618 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 677 Query: 444 LEAMNEMNDELQENARETELEL---REQLDMAG----ARVREAQKRVEAAQETVADYQQT 496 + M + +L + +E E L R +LD A + + +++ A+ V + + Sbjct: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 737 Query: 497 IKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQM 556 K + T + + +L +E ++ + + K + + + +A E +++ + Sbjct: 738 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS-EGKSEMKKLRQQLEAAEKQIKHL 796 Query: 557 EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 616 E+ + N S ++ + R L L + + + +++ +++ ++ Sbjct: 797 EI-EKNAESSKASSITRELQGRE-------LKLTNLQENLSEVSQVKETLEKELQI---- 844 Query: 617 SERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHE 676 L+ E A + S+ LH+ E + S D+ +K+ +M A Sbjct: 845 -----LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL-EKLRENLADMEAKF 898 Query: 677 RSLDFLIELL--HKDQLDETV---------NVEPLTKAIKYYQHLYSIHLAEQP-EDCTM 724 R D E L K++L+ + N LTK + L E+ E+ + Sbjct: 899 REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND------ELRLKERDVEELQL 952 Query: 725 QLA---DHIKFTQSALDCMSV--EVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCK 779 +L ++ F Q +++ M+V E + A + +E ++ L DLE C+ Sbjct: 953 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012 Query: 780 KIRRRMPGTDAPGIPAALAFGPQVSDTLLD-------CRKHLTWVVAVLQEVAAAAAQLI 832 +++ R + + TLLD R+ + ++ L+E+ A + Sbjct: 1013 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK 1072 Query: 833 APLAENEGLLVAALEELAFKASEQIYGTPSS--------SPYECLRQSCNILISTMNKLA 884 A + + + +E++ + +E + + + + L+++ + +NK Sbjct: 1073 AAQTAEDAMQI--MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1130 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 + E + ++ AA +++ + +KL + ++ S + E Sbjct: 1131 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1190 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADID 1004 E S N +L ++K+ KDADE +Q + T ALL +K+ E E+ L+ ++ Sbjct: 1191 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK----LRNEVT 1246 Query: 1005 QLEAEKAELK 1014 L E A K Sbjct: 1247 VLRGENASAK 1256 Score = 95.9 bits (237), Expect = 2e-19 Identities = 224/1095 (20%), Positives = 412/1095 (37%), Gaps = 175/1095 (15%) Query: 10 SRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69 S TPS + E RVG RV V G G + ++G T FA G+W G++LDE GKN Sbjct: 43 SSTPSSE--TQEEFVDDFRVGERVWVNGN-KPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99 Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129 DG+V G +YF C+ GIF R S++ T + D + + Sbjct: 100 DGSVAGVRYFQCEPLKGIFTRPSKL--------TRKVQAEDEA----------------N 135 Query: 130 KLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPP 189 L T PAS A+S L S + SS PSTP+ P P P A PP Sbjct: 136 GLQTTPASR----ATSPL----CTSTASMVSSSPSTPSNIPQKP---SQPAAKEPSATPP 184 Query: 190 LPSPSK----------EEEGLRAQVRDLE---------EKLETLRLKRAEDKAKLK---- 226 + + +K E ++ R+L+ K +R D AK + Sbjct: 185 ISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGV 244 Query: 227 ELEKHKIQLEQVQEWKSKMQEQQ-----ADLQRRLKEARKEAKEALEAKERYMEEMADTA 281 EL++ + + Q Q A + + K A MA T+ Sbjct: 245 ELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTS 304 Query: 282 DAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLK 341 +++ + ++ S+ V + R LT E + + + + L+ Sbjct: 305 ASLKRSPSASSLSS--MSSVASSVSSRPSRTGLLT--------ETSSRYARKISGTTALQ 354 Query: 342 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 401 + ++ + + L+ RDL E+ E K + + QEL + R + + + + E+ Sbjct: 355 EALKEKQQHIEQLLAERDL---ERAEVAKATSHVGEIEQELALARDGHD---QHVLELEA 408 Query: 402 TIDELKEQVDAALGAEEMVEMLTD------RNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 +D+L+ V+AA E VE+L + +L+ +V E T GDLE ++ Sbjct: 409 KMDQLRTMVEAA--DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL----- 461 Query: 456 ENARETELE-------------LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQ 502 E+AR ELE RE D A V E + +E ++ Q+ + R+ Sbjct: 462 EHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRR 521 Query: 503 LTAH--LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVA- 559 L ++ DV+ L+ QE S +++ T D + + K H A E E Q E+ Sbjct: 522 LESNKPAGDVDMSLSLLQEISSLQEKLEVTRT-DHQREITSLKEHFGARE-ETHQKEIKA 579 Query: 560 --QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCS 617 A +S + ++ V+ L + A +QA E+ ++S + Sbjct: 580 LYTATEKLSKENESLKSKLEHANKENSDVIA--LWKSKLETAIASHQQAMEELKVSFS-- 635 Query: 618 ERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHER 677 +G E FA + H E+ +Q E +AH + Sbjct: 636 -----KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD-----------SERAAHAK 679 Query: 678 SLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQ-SA 736 ++ L L K ++ ++E + + + HL E + IK + Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEMEDTLNKLQEAEIKVKELEV 736 Query: 737 LDCMSVEVGRLRAFLQGGQEATDIALL-LRDLETSCSDIRQFCKKIRRRMPGTDAPGIPA 795 L E ++ +AT+ LL L L + S+ + KK+R+++ + Sbjct: 737 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE------ 790 Query: 796 ALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL---------IAPLAENEGLLVAAL 846 Q+ ++ + ++ +E+ +L ++ + E + L Sbjct: 791 -----KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL 845 Query: 847 EELAFKASEQIYGTPSS-----SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKP 901 +E +ASE+ S + + N+L S + KL + + E + Sbjct: 846 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE 905 Query: 902 PPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEE-------LSEANVRLS 954 + L +I + + D + + ++ L++K + L++AN S Sbjct: 906 EQLIKAKEKLENDIAEIMKMS---GDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 962 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 L+K ++ A++ ++ + EE + L +K + E+ M+ +L+A Sbjct: 963 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 1022 Query: 1015 QRLNSQSKRTIEGLR 1029 ++ + ++ L+ Sbjct: 1023 SETKTKHEEILQNLQ 1037 Score = 80.5 bits (197), Expect = 9e-15 Identities = 93/390 (23%), Positives = 169/390 (43%), Gaps = 61/390 (15%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-KIQLEQVQEWKSKMQEQQADLQ 253 +E++ L ++ DLE+K+ET + E KA+ + K + E++ + +Q+ D + Sbjct: 988 EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ---NLQKTLLDTE 1044 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMAT----LDKEMAEERAESL-------- 301 +LK AR+E L+ E + + AD A A + A + ++M +E+ E+L Sbjct: 1045 DKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103 Query: 302 -----QQEVEALKER----VDELTTDLEIL----------KAEIEEKGSDGAASSYQLKQ 342 Q E++ LKE V+EL E+L + EIE A S QL Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163 Query: 343 LEEQNARLKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVR---QQRERLQEE 395 L+E+N +L + L R RD +S E++ V +L+E K +E + ++ +++ LQ+ Sbjct: 1164 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223 Query: 396 LS-------QAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMN 448 +S + ++ +++L+ +V G + L LE +L V +LE Sbjct: 1224 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-- 1281 Query: 449 EMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ-----TIKKYRQL 503 +L+EN R+ A R + +++ + D Q+ +K Sbjct: 1282 ----QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1337 Query: 504 TAHLQDVNRELTNQQEASVERQQQPPPETF 533 A L +L N E+Q + P F Sbjct: 1338 EAALNGNGDDLNNYDSDDQEKQSKKKPRLF 1367 >gi|38044112 restin isoform b [Homo sapiens] Length = 1392 Score = 125 bits (313), Expect = 3e-28 Identities = 241/1151 (20%), Positives = 454/1151 (39%), Gaps = 188/1151 (16%) Query: 19 SAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKY 78 S + R L++G RV ++G G V ++G T FA G+W GV LDE GKNDG V G +Y Sbjct: 204 SIKKGERELKIGDRV-LVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 262 Query: 79 FTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSA--------SKVLKREGTDTTAKT-- 128 F C +G+F +V + G +T+P ++A S LKR + ++ + Sbjct: 263 FQCQPKYGLFAPVH--KVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMS 320 Query: 129 ---SKLPTRPASTGVAGASSSLGP---SGSASAGELSSSEPSTPAQTPLAAPIIPTPVLT 182 S + +RP+ TG+ +SS SG+ + E + Q + V Sbjct: 321 SVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380 Query: 183 SPGAVPPLPSP-SKEEEGLRAQVRDLEEKLETLR-LKRAEDKAK---LKELEKHKIQLEQ 237 + V + + +G V +LE K++ LR + A D+ K L +LE+ K ++E Sbjct: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440 Query: 238 VQ------------------EWKSKMQEQQADLQRRLKEARKEAKEALEAKE-------- 271 +Q KS++ E + DL R++E E + LE+ + Sbjct: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV-AELRRRLESNKPAGDVDMS 499 Query: 272 -RYMEEMADTADAIEMATLD--------KEMAEERAESLQQEVEALKERVDELTTDLEIL 322 ++E++ + +E+ D KE R E+ Q+E++AL ++L+ + E L Sbjct: 500 LSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559 Query: 323 KAEIEEKGSDG-------------AASSYQLKQLEE--------------QNARLKDALV 355 K+++E + A +S+Q + +EE + A LK + Sbjct: 560 KSKLEHANKENSDVIALWKSKLETAIASHQ-QAMEELKVSFSKGLGTETAEFAELKTQIE 618 Query: 356 RMR-----------DLSSSEKQEH--------VKLQKLMEKKNQELEVVRQQRERLQEE- 395 +MR + SE+ H KL K++++K LE +R + ++ +++ Sbjct: 619 KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 678 Query: 396 LSQAESTIDELKEQVDAALGAEEMVEMLTDRNL------NLEEKVRELRETVGDLEAMNE 449 L + E T+++L+E A + +E+ + N N +++ E + DL+A+ + Sbjct: 679 LVEMEDTLNKLQE---AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRK 735 Query: 450 MNDELQENARETELELREQLDMAGARVR--EAQKRVEAAQETVADYQQTIKKYRQLTAHL 507 + E + + +LR+QL+ A +++ E +K E++ K +T L Sbjct: 736 ASSEGKSEMK----KLRQQLEAAEKQIKHLEIEKNAESS------------KASSITREL 779 Query: 508 QDVNRELTNQQEASVERQQQPPPETFD-----FKIKFAETKAHAKAIEMELRQM--EVAQ 560 Q +LTN QE E Q ET + K KFAE A +++ +++ ++ Q Sbjct: 780 QGRELKLTNLQENLSEVSQ--VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837 Query: 561 ANRHMSLLTAFMP---------DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE 611 ++L++ + ++ R + + L+ AE+++ + Sbjct: 838 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ 897 Query: 612 LSE-NCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYP 670 L++ N R R QL + S LQ ++ Q + KK Sbjct: 898 LTKMNDELRLKERDVEELQLKLTKA-NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956 Query: 671 EMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 730 E+ L+ +E H + E T K + + + + D + Sbjct: 957 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE----EILQNLQKTLLDTEDKL 1012 Query: 731 KFTQSALDCMSVEVGRLRA---FLQGGQEATDIALLLRDLE-------TSCSDIRQFCKK 780 K + + E+ LR + Q A D ++ + S D +Q K Sbjct: 1013 KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072 Query: 781 IRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEG 840 ++ + + + L ++ LT ++E L A+ Sbjct: 1073 LQNELDTLKENNLKNV--------EELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1124 Query: 841 LLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA-ERPPS 899 L A EE A E + ++ L + ++L + + ++ + DA E S Sbjct: 1125 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1184 Query: 900 KPPPVELRAAALRAEITDAEGLGLKLEDRETVIK---ELKKSLKIKGEELSEANVRLSLL 956 + + +A L + + E KL + TV++ KSL + L V+L L Sbjct: 1185 LQKSISITSALLTEKDAELE----KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELK 1240 Query: 957 EKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1016 K L+ K E ++ + T + E+ E +D L + I L+ + +LK + Sbjct: 1241 VKNLELQLK---ENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMK 1297 Query: 1017 LNSQSKRTIEG 1027 + S+ + G Sbjct: 1298 VEMMSEAALNG 1308 Score = 95.5 bits (236), Expect = 3e-19 Identities = 221/1077 (20%), Positives = 403/1077 (37%), Gaps = 174/1077 (16%) Query: 10 SRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69 S TPS + E RVG RV V G G + ++G T FA G+W G++LDE GKN Sbjct: 43 SSTPSSE--TQEEFVDDFRVGERVWVNGN-KPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99 Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129 DG+V G +YF C+ GIF R S++ T + D + + Sbjct: 100 DGSVAGVRYFQCEPLKGIFTRPSKL--------TRKVQAEDEA----------------N 135 Query: 130 KLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPP 189 L T PAS A+S L S + SS PSTP+ P P P A PP Sbjct: 136 GLQTTPASR----ATSPL----CTSTASMVSSSPSTPSNIPQKP---SQPAAKEPSATPP 184 Query: 190 LPSPSK----------EEEGLRAQVRDLE---------EKLETLRLKRAEDKAKLK---- 226 + + +K E ++ R+L+ K +R D AK + Sbjct: 185 ISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGV 244 Query: 227 ELEKHKIQLEQVQEWKSKMQEQQ-----ADLQRRLKEARKEAKEALEAKERYMEEMADTA 281 EL++ + + Q Q A + + K A MA T+ Sbjct: 245 ELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTS 304 Query: 282 DAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLK 341 +++ + ++ S+ V + R LT E + + + + L+ Sbjct: 305 ASLKRSPSASSLSS--MSSVASSVSSRPSRTGLLT--------ETSSRYARKISGTTALQ 354 Query: 342 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 401 + ++ + + L+ RDL E+ E K + + QEL + R + + + + E+ Sbjct: 355 EALKEKQQHIEQLLAERDL---ERAEVAKATSHVGEIEQELALARDGHD---QHVLELEA 408 Query: 402 TIDELKEQVDAALGAEEMVEMLTD------RNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 +D+L+ V+AA E VE+L + +L+ +V E T GDLE + Sbjct: 409 KMDQLRTMVEAA--DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVAT-----VS 461 Query: 456 ENARETELELREQLDMAGARVREAQKRVEA------AQETVADYQQTIKKYRQLTAHLQD 509 E +R ELE + L + V E ++R+E+ +++ Q+ +L D Sbjct: 462 EKSRIMELE--KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 519 Query: 510 VNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLT 569 RE+T+ +E R+ ET +IK T + E E + ++ AN+ S + Sbjct: 520 HQREITSLKEHFGARE-----ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 574 Query: 570 AFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR------ 623 A H + L K + E E +E ++ +R Sbjct: 575 ALWKSKLETAIASHQQAMEEL-------KVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD- 680 +Q S A + L+A L + + +K SL S +++ D Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKV----------IKEKENSLEAIRSKLDKAEDQ 677 Query: 681 FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCM 740 L+E+ +D L++ E K ++ Q C Q FT S L Sbjct: 678 HLVEM--EDTLNKLQEAEIKVKELEVLQ-----------AKCNEQTKVIDNFT-SQLKAT 723 Query: 741 SVEVGRLRAFLQGGQEA-TDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAF 799 ++ L A + E +++ L + LE + I+ +I + + A I L Sbjct: 724 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRELQG 781 Query: 800 GPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYG 859 L + ++ V L++ + A +E + +++E K ++ Sbjct: 782 RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK--- 838 Query: 860 TPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAE 919 + N+L S + KL + + E + + L +I + Sbjct: 839 ----------EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888 Query: 920 GLGLKLEDRETVIKELKKSLKIKGEE-------LSEANVRLSLLEKKLDSAAKDADERIE 972 + D + + ++ L++K + L++AN S L+K ++ A++ + Sbjct: 889 KMS---GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 945 Query: 973 KVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + + EE + L +K + E+ M+ +L+A ++ + ++ L+ Sbjct: 946 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQ 1002 Score = 80.5 bits (197), Expect = 9e-15 Identities = 93/390 (23%), Positives = 169/390 (43%), Gaps = 61/390 (15%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-KIQLEQVQEWKSKMQEQQADLQ 253 +E++ L ++ DLE+K+ET + E KA+ + K + E++ + +Q+ D + Sbjct: 953 EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ---NLQKTLLDTE 1009 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMAT----LDKEMAEERAESL-------- 301 +LK AR+E L+ E + + AD A A + A + ++M +E+ E+L Sbjct: 1010 DKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1068 Query: 302 -----QQEVEALKER----VDELTTDLEIL----------KAEIEEKGSDGAASSYQLKQ 342 Q E++ LKE V+EL E+L + EIE A S QL Sbjct: 1069 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1128 Query: 343 LEEQNARLKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVR---QQRERLQEE 395 L+E+N +L + L R RD +S E++ V +L+E K +E + ++ +++ LQ+ Sbjct: 1129 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188 Query: 396 LS-------QAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMN 448 +S + ++ +++L+ +V G + L LE +L V +LE Sbjct: 1189 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-- 1246 Query: 449 EMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ-----TIKKYRQL 503 +L+EN R+ A R + +++ + D Q+ +K Sbjct: 1247 ----QLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1302 Query: 504 TAHLQDVNRELTNQQEASVERQQQPPPETF 533 A L +L N E+Q + P F Sbjct: 1303 EAALNGNGDDLNNYDSDDQEKQSKKKPRLF 1332 >gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2 [Homo sapiens] Length = 1011 Score = 110 bits (274), Expect = 1e-23 Identities = 137/573 (23%), Positives = 251/573 (43%), Gaps = 75/573 (13%) Query: 14 SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69 SGS +S S + LR+G RV ++G G V YVG T FA G+W GV LDE GKN Sbjct: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260 Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129 DG V G +YF C G+F +V G +TSP AK Sbjct: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP-------------------AKAK 299 Query: 130 KLPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPP 189 K T+ + GV+ + S S +S ++SS P+++ L TS Sbjct: 300 K--TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTE-------TSSRYARK 350 Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAE---DKAKLKELEKH----KIQLEQ-VQEW 241 + + +E L+ + + +E+ L L+RAE + + E+EK K Q EQ V E Sbjct: 351 ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEA 410 Query: 242 KSKMQ----------EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDK 291 + K+Q +++ DL +L+E R++ +E + +EE + T +E+ T+ + Sbjct: 411 EEKLQRARLLVESVRKEKVDLSNQLEEERRK----VEDLQFRVEEESITKGDLELTTVAE 466 Query: 292 EMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ--LEEQNAR 349 + R L++E+ + ++EL L L + AA +L++ L Sbjct: 467 ---KSRVLQLEEELTLRRGEIEELQQCL--LHSGPPPPDHPDAAEILRLRERLLSASKEH 521 Query: 350 LKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQ 409 +++ V + K ++ KL + + V ++++Q+ S+ +D K + Sbjct: 522 QRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSK 581 Query: 410 VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 469 +D+ A + + L D L ++ +G+L+A+ E +++ L+ + L Sbjct: 582 LDSL--ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQAKHDL 638 Query: 470 DMA-GARVREA-QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 527 + A + +EA +++++ AQE +A Q+ + ++ A + + Q E + Sbjct: 639 ETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELR-- 696 Query: 528 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560 + + E + A+AIE Q+ +A+ Sbjct: 697 ----VHELEKLDVEYRGQAQAIEFLKEQISLAE 725 Score = 84.3 bits (207), Expect = 6e-16 Identities = 132/563 (23%), Positives = 228/563 (40%), Gaps = 83/563 (14%) Query: 4 SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49 S H S PS S +A A +P VG RV V G G V Y+G Sbjct: 42 SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100 Query: 50 TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107 T FA G+W GV+LD+ GKNDG V G +YF C GIF R S++ Q +G+ + + Sbjct: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160 Query: 108 TPDSSASKVLKREGTDTTAKTSK-LPTRPA---STGVAG--ASSSLGPSGSASAGE---- 157 +A + GT T TS+ +P R + S+ G + S+L SGS GE Sbjct: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLR 220 Query: 158 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE--------- 208 L +T + + T L P + +G A R + Sbjct: 221 LGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFA 280 Query: 209 EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEAL 267 + +R+ + AK K+ ++ + + + S R L Sbjct: 281 PIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLL 340 Query: 268 -EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVEALKERVDELTTDLE 320 E RY +++ T A++ A +K+ +AE E + EV + E+ ++ Sbjct: 341 TETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVAKATSHICEVEKEIA 397 Query: 321 ILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQ 380 +LKA Q E+ A ++ L R R L S ++E V L +E++ + Sbjct: 398 LLKA-----------------QHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR 440 Query: 381 ELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET 440 ++E ++ + E +E +++ + + + E+ ++ E LT R +EE + L + Sbjct: 441 KVEDLQFRVE--EESITKGDLELTTVAEKSRVL----QLEEELTLRRGEIEELQQCLLHS 494 Query: 441 ------VGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQ 494 D + + + L ++E + E +G + +K ++A Q V + Sbjct: 495 GPPPPDHPDAAEILRLRERLLSASKEHQRE-------SGVLRDKYEKALKAYQAEVDKLR 547 Query: 495 QTIKKYRQLTAHLQDVNRELTNQ 517 +KY Q A L+D ++ T++ Sbjct: 548 AANEKYAQEVAGLKDKVQQATSE 570 Score = 42.7 bits (99), Expect = 0.002 Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%) Query: 198 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 E L+ Q+ E+K L+ RL+RAE + K +E+E + +L + ++ + + Sbjct: 715 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 773 Query: 257 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 E+ ++E + KE +++ + T EM + +L+ + ++ +++VD Sbjct: 774 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 833 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 L + L+AE+E +S QL + ++ R + +L +R L Sbjct: 834 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 880 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 L+E R L E+ +AE I E K + D E++ + +++L+ Sbjct: 881 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 932 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 + R ++ D + E+ LQ TE LR+ LD A ++ +K +E A + D Sbjct: 933 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 985 Query: 494 QQTI 497 QTI Sbjct: 986 AQTI 989 >gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1 [Homo sapiens] Length = 1046 Score = 108 bits (270), Expect = 3e-23 Identities = 131/577 (22%), Positives = 248/577 (42%), Gaps = 48/577 (8%) Query: 14 SGSRMSAEASAR----PLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKN 69 SGS +S S + LR+G RV ++G G V YVG T FA G+W GV LDE GKN Sbjct: 202 SGSNLSDSGSVKRGEKDLRLGDRV-LVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKN 260 Query: 70 DGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTS 129 DG V G +YF C G+F +V G +TSP + +K KR +A T Sbjct: 261 DGAVAGTRYFQCPPKFGLFAPIH--KVIRIGFPSTSP-----AKAKKTKRMAMGVSALTH 313 Query: 130 KLPTRPASTGVAGASSSLG--PSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAV 187 P+ + + V+ +SS+G PS S E SS + T + + Sbjct: 314 S-PSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLL 372 Query: 188 PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKE-LEKHKIQLEQVQEWKSKMQ 246 E + + ++E+++ L+ + + A+ +E L++ ++ +E V++ K + Sbjct: 373 AERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLS 432 Query: 247 EQQADLQRRLKEARKEAKEAL----EAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 302 Q + +R++++ + +E + + + E A + + L+K AE L Sbjct: 433 NQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELA 492 Query: 303 QE---VEALKERVDELTTDLEILKAEIEE------------KGSDGAASSYQLKQ--LEE 345 A K RV +L +L + + EIEE AA +L++ L Sbjct: 493 DNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSA 552 Query: 346 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 405 +++ V + K ++ KL + + V ++++Q+ S+ +D Sbjct: 553 SKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDN 612 Query: 406 LKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 465 K ++D+ A + + L D L ++ +G+L+A+ E +++ L+ Sbjct: 613 WKSKLDSL--ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQA 669 Query: 466 REQLDMA-GARVREA-QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 523 + L+ A + +EA +++++ AQE +A Q+ + ++ A + + Q E Sbjct: 670 KHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAE 729 Query: 524 RQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560 + + + E + A+AIE Q+ +A+ Sbjct: 730 LR------VHELEKLDVEYRGQAQAIEFLKEQISLAE 760 Score = 89.7 bits (221), Expect = 2e-17 Identities = 139/585 (23%), Positives = 233/585 (39%), Gaps = 92/585 (15%) Query: 4 SKRHVYSRTPSGSRMSAEASARP--------------LRVGSRVEVIGKGHRGTVAYVGA 49 S H S PS S +A A +P VG RV V G G V Y+G Sbjct: 42 SPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGV-KPGVVQYLGE 100 Query: 50 TLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQI--QVFEDGADTTSPE 107 T FA G+W GV+LD+ GKNDG V G +YF C GIF R S++ Q +G+ + + Sbjct: 101 TQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHS 160 Query: 108 TPDSSASKVLKREGTDTTAKTSK-LPTRPA---STGVAG--ASSSLGPSGSASAGE---- 157 +A + GT T TS+ +P R + S+ G + S+L SGS GE Sbjct: 161 VESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLR 220 Query: 158 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE--------- 208 L +T + + T L P + +G A R + Sbjct: 221 LGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFA 280 Query: 209 EKLETLRLK-RAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEAL 267 + +R+ + AK K+ ++ + + + S R L Sbjct: 281 PIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLL 340 Query: 268 -EAKERYMEEMADTADAIEMATLDKE------MAEERAESLQQEVEALKERVDELTTDLE 320 E RY +++ T A++ A +K+ +AE E + EV + E+ ++ Sbjct: 341 TETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLE--RAEVAKATSHICEVEKEIA 397 Query: 321 ILKAEIEEKGSDGAASSYQLK---------------QLEEQNARLKDALVRMR------- 358 +LKA+ E+ ++ + + QLEE+ +++D R+ Sbjct: 398 LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKG 457 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 DL + + EH ++ +L Q L + + Q ERL EL+ T K +V + Sbjct: 458 DLETQTQLEHARIGEL----EQSLLLEKAQAERLLRELADNRLTTVAEKSRV------LQ 507 Query: 419 MVEMLTDRNLNLEEKVRELRET------VGDLEAMNEMNDELQENARETELELREQLDMA 472 + E LT R +EE + L + D + + + L ++E + E + Sbjct: 508 LEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRE-------S 560 Query: 473 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 517 G + +K ++A Q V + +KY Q A L+D ++ T++ Sbjct: 561 GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSE 605 Score = 42.7 bits (99), Expect = 0.002 Identities = 69/304 (22%), Positives = 133/304 (43%), Gaps = 33/304 (10%) Query: 198 EGLRAQVRDLEEK-LETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 E L+ Q+ E+K L+ RL+RAE + K +E+E + +L + ++ + + Sbjct: 750 EFLKEQISLAEKKMLDYERLQRAEAQGK-QEVESLREKLLVAENRLQAVEALCSSQHTHM 808 Query: 257 KEARKEAKEALEAKERY---MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 E+ ++E + KE +++ + T EM + +L+ + ++ +++VD Sbjct: 809 IESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVD 868 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 L + L+AE+E +S QL + ++ R + +L +R L Sbjct: 869 ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVL------------- 915 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 L+E R L E+ +AE I E K + D E++ + +++L+ Sbjct: 916 LLEANRHSPGPERD----LSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLS---- 967 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 + R ++ D + E+ LQ TE LR+ LD A ++ +K +E A + D Sbjct: 968 -DQRRYSLIDPSSAPELL-RLQHQLMSTEDALRDALDQA----QQVEKLME-AMRSCPDK 1020 Query: 494 QQTI 497 QTI Sbjct: 1021 AQTI 1024 >gi|156104908 myosin heavy chain 6 [Homo sapiens] Length = 1939 Score = 106 bits (265), Expect = 1e-22 Identities = 188/960 (19%), Positives = 389/960 (40%), Gaps = 154/960 (16%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 242 K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K Sbjct: 912 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971 Query: 243 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 + E+ A L + + KE K EA ++ ++++ D + + K E+ Sbjct: 972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031 Query: 297 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLKQLE----E 345 + + L+ +E K+ R+D +L DL++ + I + +D +LK+ E + Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091 Query: 346 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 405 QN++++D V L K+ ++++L E ELE R R ++++ S ++E Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEE----ELEAERTARAKVEKLRSDLSRELEE 1147 Query: 406 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 464 + E+++ A GA + +EM R ++ R+L E EA L++ ++ E Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1204 Query: 465 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 524 L EQ+D ++ +K + + D +++ + A+L+ V+R L +Q + Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264 Query: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 574 ++ DF + A+ + + +L + E ++Q R T M D Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE 1324 Query: 575 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 615 + HDC L+ + R++ KA Q + K+E + Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384 Query: 616 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 671 E + ++L A V ++ S L+ T HR ++ + VDV ++ + Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1443 Query: 672 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 730 + +R+ D L E K + ++ +A L+ + A + + +H+ Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1497 Query: 731 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 789 + + + E+ L L +GG+ ++ + + LE +++ ++ + + Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557 Query: 790 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 839 + A L F + + + +++ VV LQ A + + + Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617 Query: 840 GLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPS 899 + L E+ + S ++ + ++ ++L T +L A++ + E Sbjct: 1618 KKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675 Query: 900 KPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL--- 956 VE R L+AE LE+ V+++ ++S K+ +EL E + R+ LL Sbjct: 1676 ----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721 Query: 957 -------EKKLDS--------------AAKDADERIEKVQT----------RLEETQALL 985 +KK++S ++A+E+ +K T + ++T A L Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1781 Query: 986 RKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTIEGLRG 1030 + +K E+T+ LQ +D+ LEA EL+ L ++ KR E ++G Sbjct: 1782 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKG 1841 Score = 77.8 bits (190), Expect = 6e-14 Identities = 163/845 (19%), Positives = 342/845 (40%), Gaps = 103/845 (12%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKSKMQEQQADL 252 KE ++ + ++E LE +R E + K+ L EK+ +QL+ E Q+ D Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE-----QDNLNDA 903 Query: 253 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 312 + R + K K LEAK + M E + + + K+ L+ E LK+ + Sbjct: 904 EERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLEDECSELKKDI 956 Query: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 372 D DLE+ A++E++ A+ ++K L E+ A L + + ++ + EK + Sbjct: 957 D----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TKEK------K 999 Query: 373 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLE 431 L E Q L+ ++ + +++ LS+++ +++ + ++ +L E+ V M +R LE Sbjct: 1000 ALQEAHQQALDDLQVEEDKV-NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1058 Query: 432 EKVRELRETVGDLEAMNEMNDELQ--ENARETELELREQ---LDMAGARVREAQKRVEAA 486 ++ +E++ DLE ND+LQ E ++ E ++ +Q ++ + QK+++ Sbjct: 1059 GDLKLTQESIMDLE-----NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113 Query: 487 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 546 Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++ K Sbjct: 1114 QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEMNKKRE 1170 Query: 547 KAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 604 + R +E A Q + L DS G D + + K +L ++ Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQKLEKE 1222 Query: 605 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 664 +++ K EL + S + A + L + + L + +L+ + K Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAK 1281 Query: 665 VGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTM 724 + + E++ + LI L + +L T +E L + + E+ Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL------------EEEGKAKN 1329 Query: 725 QLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRR 784 LA ++ + D + Q +E A L R L + S++ Q+ K Sbjct: 1330 ALAHALQSARHDCDLLRE---------QYEEETEAKAELQRVLSKANSEVAQWRTKYE-- 1378 Query: 785 MPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA 844 TDA Q ++ L + +K L + +E A + L + + L Sbjct: 1379 ---TDA----------IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425 Query: 845 ALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 904 +E+L +++ + R IL K + E E + S + Sbjct: 1426 EIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483 Query: 905 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAA 964 A + E + ++ + I +L + L G+ + E L + K+L+ Sbjct: 1484 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE----LEKVRKQLEVEK 1539 Query: 965 KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRT 1024 + +E+ + LE + + + + EF + ++A+I++ AEK E ++ +R Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEMEQAKRNHQRV 1595 Query: 1025 IEGLR 1029 ++ L+ Sbjct: 1596 VDSLQ 1600 Score = 74.3 bits (181), Expect = 7e-13 Identities = 178/884 (20%), Positives = 366/884 (41%), Gaps = 134/884 (15%) Query: 192 SPSKEEEGLRAQVRDLEEKLET-----LRLKRAEDKAK---------LKELEKHKIQLEQ 237 S SK + L QV DLE LE + L+RA+ K + + +LE K+QLE+ Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080 Query: 238 --------VQEWKSKMQEQQA---DLQRRLKEAR---KEAKEALEAKER----------- 272 + + SK++++Q LQ++LKE + +E +E LEA+ Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140 Query: 273 YMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSD 332 E+ + ++ +E A + E + + E + ++ ++E T E A + +K +D Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200 Query: 333 GAASSYQ----LKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELE-VVRQ 387 A + L++++++ + K D +S ++ +K + +EK ++ LE + Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260 Query: 388 QRERLQE----------ELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVREL 437 R +L+E + ++ ++ EL Q++ E ++ LT L+ +++ +L Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK---EALISQLTRGKLSYTQQMEDL 1317 Query: 438 -RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQT 496 R+ + +A N + LQ + +L LREQ + E Q+ + A VA ++ Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKANSEVAQWRT- 1375 Query: 497 IKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 552 KY Q T L++ ++L + + + E E + K E H E+E Sbjct: 1376 --KYETDAIQRTEELEEAKKKLAQRLQDAEEAV-----EAVNAKCSSLEKTKHRLQNEIE 1428 Query: 553 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFEL 612 ++V ++N + L + + D +L AE +K + + EL Sbjct: 1429 DLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWKQKYEESQSEL 1469 Query: 613 SENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEM 672 + E R + E SL L+ T R L + D+ +++G E Sbjct: 1470 ESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLTEQLG----EG 1521 Query: 673 SAHERSLDFLIELLHKDQLDETVNVEP------------LTKAIKYYQHLYSIH--LAEQ 718 + L+ + + L ++L+ +E L +++ Q I LAE+ Sbjct: 1522 GKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1581 Query: 719 PEDCTMQLADH---IKFTQSALDCMSV---EVGRLRAFLQGGQEATDIALLLRDLETSCS 772 E+ +H + Q++LD + EV R++ ++G + ++ + L + Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEIQLSHANRMAA 1639 Query: 773 DIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQL- 831 + ++ K ++ + T + A+ + + + + + A L+E+ A Q Sbjct: 1640 EAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1698 Query: 832 -IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 890 LAE E L+ E + Q+ + ++S ++ + L +++ A+QE Sbjct: 1699 RSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750 Query: 891 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 950 E+ + A L+ E + L ++ E IK+L+ L + E+++ Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-EAEQIALKG 1809 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 994 + L +KL++ ++ + +E Q R E+ +RK E+ +E Sbjct: 1810 GKKQL--QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851 Score = 63.9 bits (154), Expect = 9e-10 Identities = 65/310 (20%), Positives = 132/310 (42%), Gaps = 58/310 (18%) Query: 212 ETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE 271 E LR+K+ + +L + +IQL ++ Q+Q LQ LK+ + + +A+ A + Sbjct: 1612 EVLRVKKKMEG----DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667 Query: 272 RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS 331 E +A + E R LQ E+E L+ V++ ++ + E+ E Sbjct: 1668 DLKENIA--------------IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE--- 1710 Query: 332 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER 391 +S +++ L QN L + +K+ L +L + + ++ R E+ Sbjct: 1711 ----TSERVQLLHSQNT----------SLINQKKKMESDLTQLQSEVEEAVQECRNAEEK 1756 Query: 392 LQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE--------------- 436 ++ ++ A +ELK++ D + E M + + +L+ ++ E Sbjct: 1757 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1816 Query: 437 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492 +RE G+LEA + N E + R++E ++E + E +K + Q+ V Sbjct: 1817 LEARVRELEGELEAEQKRNAESVKGMRKSERRIKE----LTYQTEEDKKNLLRLQDLVDK 1872 Query: 493 YQQTIKKYRQ 502 Q +K Y++ Sbjct: 1873 LQLKVKAYKR 1882 Score = 57.8 bits (138), Expect = 6e-08 Identities = 63/276 (22%), Positives = 121/276 (43%), Gaps = 49/276 (17%) Query: 207 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 255 L+ +LE LR +++ E KL E E ++QL Q K KM+ LQ Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE 1742 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE Sbjct: 1743 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1802 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 +I KG KQL++ AR+++ + +E++ + + K M Sbjct: 1803 E--------QIALKGGK--------KQLQKLEARVRE----LEGELEAEQKRNAESVKGM 1842 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN------ 429 K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+ Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902 Query: 430 ------------LEEKVRELRETVGDLEAMNEMNDE 453 E +V +LR D+ A +M+DE Sbjct: 1903 HELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDE 1938 Score = 34.7 bits (78), Expect = 0.59 Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 5/172 (2%) Query: 848 ELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELR 907 +L FK + + +++ + T+ K +E E + ++L+ Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892 Query: 908 AAALRAEITDAEGLGLKLEDR----ETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSA 963 A + + DAE +L E +KE+ + L+ + E +E + LE + Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952 Query: 964 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 KD D+ +E ++E+ + K K E M L I +L EK L++ Sbjct: 953 KKDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003 >gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo sapiens] Length = 1935 Score = 99.4 bits (246), Expect = 2e-20 Identities = 190/965 (19%), Positives = 388/965 (40%), Gaps = 164/965 (16%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH-----------KIQLEQVQEWK- 242 K + L A+V+++ E+LE AE AK ++LE ++ L +V++ K Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKH 969 Query: 243 ------SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 + E+ A L + + KE K EA ++ ++++ D + T K E+ Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029 Query: 297 RAESLQQEVEALKE-RVD------ELTTDLEILKAEIEEKGSDGAASSYQLK----QLEE 345 + + L+ +E K+ R+D +L DL++ + I + +D +LK +L Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089 Query: 346 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 405 NAR++D + L S +++ +LQ +E+ +ELE R R ++++ S ++E Sbjct: 1090 LNARIEDE----QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145 Query: 406 LKEQVDAALGAEEM-VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE 464 + E+++ A GA + +EM R ++ R+L E EA L++ ++ E Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA---LRKKHADSVAE 1202 Query: 465 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 524 L EQ+D ++ +K + + D +++ + A+L+ + R L +Q + Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262 Query: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQME--VAQANRHMSLLTAFMPD-------- 574 ++ D + A+ + + +L + E ++Q R T + D Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322 Query: 575 -------SFLRPGGDHDCVLVL----------LLMPRLICKAELIRKQAQEKFELS--EN 615 + HDC L+ + R++ KA Q + K+E + Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382 Query: 616 CSERPGLRGAAGEQLSFAAGLVYSL----SLLQATLHRYEHALSQCSVDVYKKVGSLYPE 671 E + ++L A V ++ S L+ T HR ++ + VDV ++ + Sbjct: 1383 TEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAA 1441 Query: 672 MSAHERSLD-FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHI 730 + +R+ D L E K + ++ +A L+ + A + + +H+ Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE------ESLEHL 1495 Query: 731 KFTQSALDCMSVEVGRLRAFL-QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 789 + + + E+ L L G+ ++ + + LE +++ ++ + + Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555 Query: 790 APGIPAALAFGP----------QVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENE 839 + A L F + + + +++ VV LQ A + + NE Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR-----SRNE 1610 Query: 840 GLLVAA-----LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 L V L E+ + S ++ + ++ ++L T +L A++ + Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E VE R L+AE LE+ V+++ ++S K+ +EL E + R+ Sbjct: 1669 ENIAI----VERRNNLLQAE----------LEELRAVVEQTERSRKLAEQELIETSERVQ 1714 Query: 955 LL----------EKKLDS--------------AAKDADERIEKVQT----------RLEE 980 LL +KK+D+ ++A+E+ +K T + ++ Sbjct: 1715 LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774 Query: 981 TQALLRKKEKEFEETMDALQADIDQ---------------LEAEKAELKQRLNSQSKRTI 1025 T A L + +K E+T+ LQ +D+ LEA EL+ L ++ KR Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNA 1834 Query: 1026 EGLRG 1030 E ++G Sbjct: 1835 ESVKG 1839 Score = 86.7 bits (213), Expect = 1e-16 Identities = 177/854 (20%), Positives = 346/854 (40%), Gaps = 105/854 (12%) Query: 188 PPLPSPSKEEE--GLRAQVRDLEEKLETLRLKRAEDKAKLKEL--EKHKIQLEQVQEWKS 243 P L S +E+E ++ + L+E LE +R E + K+ L EK+ +QL+ E Sbjct: 838 PLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE--- 894 Query: 244 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303 Q+ AD + R + K K LEAK + M E + + + K+ L+ Sbjct: 895 --QDNLADAEERCDQLIKN-KIQLEAKVKEMNERLEDEEEMNAELTAKK------RKLED 945 Query: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363 E LK +D DLE+ A++E++ A+ ++K L E+ A L + + ++ + Sbjct: 946 ECSELKRDID----DLELTLAKVEKEKH---ATENKVKNLTEEMAGLDEIIAKL----TK 994 Query: 364 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423 EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ V M Sbjct: 995 EK------KALQEAHQQALDDLQAEEDKV-NTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047 Query: 424 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARVREAQK 481 +R LE ++ +E++ DLE + DE + ++ EL L +++ A + QK Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDE-RLKKKDFELNALNARIEDEQALGSQLQK 1106 Query: 482 RVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAE 541 +++ Q + + ++ ++ R A ++ + +L+ + E ER ++ T ++ Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT---SVQIEM 1163 Query: 542 TKAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKA 599 K + R +E A Q + L DS G D + + K Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV--------KQ 1215 Query: 600 ELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSV 659 +L +++++ K EL + S + A L Q HR + +Q SV Sbjct: 1216 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED-----QMNEHRSKAEETQRSV 1270 Query: 660 -DVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ + L E R LD ++ + LT+ Y +Q Sbjct: 1271 NDLTSQRAKLQTENGELSRQLD-----------EKEALISQLTRGKLTY--------TQQ 1311 Query: 719 PEDCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR 775 ED QL + +K + AL + LR Q +E A L R L + S++ Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE--QYEEETEAKAELQRVLSKANSEVA 1369 Query: 776 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 835 Q+ K TDA Q ++ L + +K L + +E A + L Sbjct: 1370 QWRTKYE-----TDA----------IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414 Query: 836 AENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAE 895 + + L +E+L +++ + R IL K + E E + Sbjct: 1415 EKTKHRLQNEIEDLMVDVERS--NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472 Query: 896 RPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL 955 S + A + E + ++ + I +L + L G+ + E L Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE----LEK 1528 Query: 956 LEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 + K+L++ + +E+ + LE + + + + EF + ++A+I++ AEK E + Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ----IKAEIERKLAEKDEEME 1584 Query: 1016 RLNSQSKRTIEGLR 1029 + R ++ L+ Sbjct: 1585 QAKRNHLRVVDSLQ 1598 Score = 80.5 bits (197), Expect = 9e-15 Identities = 166/832 (19%), Positives = 334/832 (40%), Gaps = 101/832 (12%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E L A++ D + L+ K E +A+++ELE+ +LE + ++K+++ ++DL R Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEE---ELEAERTARAKVEKLRSDLSRE 1142 Query: 256 LKEARKEAKEA-------LEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEVEA 307 L+E + +EA +E ++ E +E ATL E A + V Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 L E++D +L+ +K ++E++ S+ + EQ + K L +M + E Sbjct: 1203 LGEQID----NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258 Query: 368 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 H + E+ + + + QR +LQ E + +DE E ++ LT Sbjct: 1259 H---RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE----------KEALISQLTRGK 1305 Query: 428 LNLEEKVREL-RETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 486 L +++ +L R+ +++A N + LQ + +L LREQ + E Q+ + A Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LREQYEEETEAKAELQRVLSKA 1364 Query: 487 QETVADYQQTIKKYR----QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 542 VA ++ KY Q T L++ ++L + + + E E + K E Sbjct: 1365 NSEVAQWRT---KYETDAIQRTEELEEAKKKLAQRLQEAEEAV-----EAVNAKCSSLEK 1416 Query: 543 KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELI 602 H E+E ++V ++N + L + + D +L AE Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALD--------KKQRNFDKIL-----------AEWK 1457 Query: 603 RKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVY 662 +K + + EL + E R + E SL L+ T R L + D+ Sbjct: 1458 QKYEESQSELESSQKEA---RSLSTELFKLKNAYEESLEHLE-TFKRENKNLQEEISDLT 1513 Query: 663 KKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 712 +++GS + ++ A + L +E E + L +++ Q Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAE 1571 Query: 713 IH--LAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRAFLQGGQEATDIALLL 764 I LAE+ E+ +H++ S + E R++ ++G + ++ + L Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG--DLNEMEIQL 1629 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 ++ ++ K ++ + T + A+ + + + + + A L+E+ Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688 Query: 825 AAAAAQL--IAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNK 882 A Q LAE E L+ E + Q+ + ++S ++ L + Sbjct: 1689 RAVVEQTERSRKLAEQE--LIETSERV------QLLHSQNTSLINQKKKMDADLSQLQTE 1740 Query: 883 LATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIK 942 + A+QE E+ + A L+ E + L ++ E IK+L+ L + Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD-E 1799 Query: 943 GEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEE 994 E+++ + L +KL++ ++ + +E Q R E+ +RK E+ +E Sbjct: 1800 AEQIALKGGKKQL--QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849 Score = 65.5 bits (158), Expect = 3e-10 Identities = 85/429 (19%), Positives = 188/429 (43%), Gaps = 71/429 (16%) Query: 198 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQRRL 256 E + + ++L+E++ L + + ELEK + QLE + E +S ++E +A L+ Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555 Query: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERV--- 312 + + E + K ++A+ + +E A + + + SL E + E + Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615 Query: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDL--SSSEKQEHVK 370 ++ DL ++ ++ A + Q+K L+ + LKD +++ D ++ + +E++ Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ---SLLKDTQIQLDDAVRANDDLKENIA 1672 Query: 371 L----QKLMEKKNQELEVVRQQRER--------------------------------LQE 394 + L++ + +EL V +Q ER + Sbjct: 1673 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732 Query: 395 ELSQAESTIDELKEQ------------VDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 442 +LSQ ++ ++E ++ DAA+ AEE+ + D + +LE + + +T+ Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIK 1791 Query: 443 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ----ETVADYQQTIK 498 DL+ DE ++ A + ++QL ARVRE + +EA Q E+V +++ + Sbjct: 1792 DLQ---HRLDEAEQIALKGG---KKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845 Query: 499 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 558 + ++LT ++ + L Q+ + + Q + + + + AE +A+ + Q E+ Sbjct: 1846 RIKELTYQTEEDRKNLLRLQD--LVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903 Query: 559 AQANRHMSL 567 +A + Sbjct: 1904 DEAEERADI 1912 Score = 57.0 bits (136), Expect = 1e-07 Identities = 61/266 (22%), Positives = 122/266 (45%), Gaps = 32/266 (12%) Query: 207 LEEKLETLR--LKRAEDKAKLKELE----KHKIQLEQVQEW-----KSKMQEQQADLQRR 255 L+ +LE LR +++ E KL E E ++QL Q K KM + LQ Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++EA +E + A E ++ + + A A+ ++ E ++++Q ++ L+ R+DE Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 +I KG KQL++ AR+++ + + +E++ + + K M Sbjct: 1801 E--------QIALKGGK--------KQLQKLEARVRE----LENELEAEQKRNAESVKGM 1840 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 K + ++ + Q E ++ L + + +D+L+ +V A E E + NL+ KV+ Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1900 Query: 436 -ELRETVGDLEAMNEMNDELQENARE 460 EL E + ++L+ +R+ Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRD 1926 Score = 50.4 bits (119), Expect = 1e-05 Identities = 128/633 (20%), Positives = 250/633 (39%), Gaps = 76/633 (12%) Query: 410 VDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 469 +D+ GAE+++ L + + ++ G L + EM DE R + + R Q Sbjct: 736 IDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDE-----RLSRIITRIQA 790 Query: 470 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 529 G R K++ ++++ Q I+ + + S ER+++ Sbjct: 791 QSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMA 850 Query: 530 PETFDF-KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLV 588 +F ++K A K+ A+ E+E + + + Q + L D+ + C + Sbjct: 851 SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQL 908 Query: 589 LLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLH 648 + +L K + + ++ +++ E++ +E + ++ S + L L A + Sbjct: 909 IKNKIQLEAKVKEMNERLEDEEEMN---AELTAKKRKLEDECSELKRDIDDLELTLAKVE 965 Query: 649 RYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFL------IELLHKDQLD----ETVNVE 698 + +HA KV +L EM+ + + L ++ H+ LD E V Sbjct: 966 KEKHATEN-------KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018 Query: 699 PLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEAT 758 LTKA + L +Q +D L K + +++ R + L+G + T Sbjct: 1019 TLTKA--------KVKLEQQVDDLEGSLEQEKK--------VRMDLERAKRKLEGDLKLT 1062 Query: 759 DIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVV 818 +++ DLE + + KK + +A I A G Q+ L K L + Sbjct: 1063 QESIM--DLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKL----KELQARI 1115 Query: 819 AVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIS 878 L+E A A + + L LEE++ + E T ++ I Sbjct: 1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT-------------SVQIE 1162 Query: 879 TMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEG-LGLKLEDRETVIKELKK 937 K Q+ D E + E AAALR + D+ LG ++++ + V ++L+K Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQH---EATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219 Query: 938 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMD 997 E SE + L + ++ K A +EK+ LE+ R K +E + +++ Sbjct: 1220 -------EKSEFKLELDDVTSNMEQIIK-AKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271 Query: 998 ALQADIDQLEAEKAELKQRLNSQSKRTIEGLRG 1030 L + +L+ E EL ++L+ + + RG Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304 Score = 42.4 bits (98), Expect = 0.003 Identities = 34/133 (25%), Positives = 67/133 (50%), Gaps = 13/133 (9%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKM 245 L K+ + L A+VR+LE +LE + + AE +++ E+ Q E+ ++ ++ Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864 Query: 246 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQE 304 Q+ LQ ++K +++A+EA EE A+T + + AEERA+ + + Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEA--------EEQANTNLSKFRKVQHELDEAEERADIAESQ 1916 Query: 305 VEALKERVDELTT 317 V L+ + ++ T Sbjct: 1917 VNKLRAKSRDIGT 1929 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 97.4 bits (241), Expect = 7e-20 Identities = 208/949 (21%), Positives = 367/949 (38%), Gaps = 154/949 (16%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-------KHKIQLEQVQEWKSKMQE 247 +E+ L +V +L+ +ET R ++ E +A++ ELE + + E+V + K ++QE Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702 Query: 248 QQADLQRRLK-------EARKEAKEALEAKERYMEEM-ADTADAIEMATLD-KEMAEERA 298 Q L+ LK E ++ A +ALE ++R + E+ A+T +E + KE+ EERA Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762 Query: 299 -------------ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAA--SSYQLKQL 343 E+ Q E E L+ + E ++E E+ + AA Y+ Q Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822 Query: 344 EE--QNARLKDALVRMRDLSSSEKQEHVKLQKLMEK-----KNQELEVVRQQRERLQEEL 396 EE A ++ L+ +++ +QE LQ+ EK + EL++ RQ Q EL Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQE---LQEAKEKVAGIESHSELQISRQ-----QNEL 874 Query: 397 SQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQE 456 ++ + + +QV E + L D L+EK+ + V LE + E QE Sbjct: 875 AELHANLARALQQVQE---KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931 Query: 457 NARETELELREQLDMAGARVRE------------AQKRVEAAQETVADYQQTIKKYRQLT 504 A EL ++ AG R E Q ++A + +++ R Sbjct: 932 TASR---ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988 Query: 505 AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRH 564 Q +E QQE V R Q E + A KA +EM L+ Q Sbjct: 989 MESQGQQQEERGQQEREVARLTQ---ERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045 Query: 565 MSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERPGLR 623 +L A + G D + + L I + E +R+ ++ K +L++ E Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105 Query: 624 GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERS---LD 680 GA E L L+A + + E QC ++ SL + A S D Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLE---QQCQKQ-QEQADSLERSLEAERASRAERD 1161 Query: 681 FLIELLHKDQLDETVN--------VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLA---DH 729 +E L + QL+E + + + ++ H ++ ++ Q+A Sbjct: 1162 SALETL-QGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH-SKAEDEWKAQVARGRQE 1219 Query: 730 IKFTQSALDCMSVEVGRL-RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 788 + S + + EV L R L+ E+ ++ L+ + + + ++ Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASN 1279 Query: 789 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 848 A + A +V + K + QE+ + A + AE G + A +E Sbjct: 1280 SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER-----AEELGQELKAWQE 1334 Query: 849 LAFKASEQIYGTPSSSPYECLRQSCNILISTM---NKLATAMQEGEYDAER------PPS 899 F+ + + S + S L+S + L +Q + AE+ S Sbjct: 1335 KFFQKEQAL------STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388 Query: 900 KPPPVELRAAALRA--EITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---------- 947 K LRA LRA E+ + L K+ ++E ++L+ E+LS Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448 Query: 948 --------EANVRLSLLEKKLDSAAK-----------DADERIEKVQTRLEETQALLR-- 986 AN+ LE +LD A + DA+ R+ +VQ + T L Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVM 1508 Query: 987 ------------KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023 ++ + F+E L A ++QLE + E +++ SK+ Sbjct: 1509 TAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557 Score = 88.6 bits (218), Expect = 3e-17 Identities = 227/1103 (20%), Positives = 416/1103 (37%), Gaps = 190/1103 (17%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ------------VQEWK 242 K+ + L+ + ++ K+ L + + KL+E H QL+ QEW Sbjct: 297 KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWL 356 Query: 243 SKMQEQQADLQRRL--KEARKEAKEALEAK----ERYMEEMADT---------ADAIEMA 287 K + + +L L K+ +E E L+ K E ++ ++ D D +++ Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416 Query: 288 TLDKEMA---------EERAESL-----QQEVEALKER---------VDELTTDLEI--- 321 TL +E A + R E L QQE + L ER + L TDL+ Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476 Query: 322 ----LKAEIEEKG-SDGAASSYQLKQLEEQ----NARLKDALVRMRDLSSSEKQEHVKLQ 372 K E+E+ + GA + Q+ L + NA ++ + L K++ +L Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536 Query: 373 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA---------ALGAEEMVEML 423 + ++++ Q + +R Q E+L L Q E + E+ E+ +A A AEE L Sbjct: 537 QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596 Query: 424 TDRNLNL-------EEKVRELRETVGDLEAMNEMNDELQEN---ARETELELREQLDMAG 473 +R+ L +EK +L L+ NE D Q + A+ + EL +++ Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656 Query: 474 ARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE-------------A 520 A V A++ AQ VA+ + ++ +Q + V +E QE Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716 Query: 521 SVERQQQPPPETFDFKIKF-----AETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 575 S+E +++ + + + + AET++ + + E +++E +A R + Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR------KGLEAR 770 Query: 576 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFE--LSENCSERPGLRGAAGEQLSFA 633 + G H +L R + +A + A+ + E + E + R + E+ + Sbjct: 771 LQQLGEAHQAETEVL--RRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828 Query: 634 AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDE 693 A L L+ + L + +KV + +H EL Q +E Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAK----EKVAGI----ESHS-------ELQISRQQNE 873 Query: 694 TVNVEP-LTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQ 752 + L +A++ Q + E +LAD + Q + S EV RL ++ Sbjct: 874 LAELHANLARALQQVQ---------EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924 Query: 753 --GGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDC 810 G Q+ T L+++ + ++ ++ + R + + A Q+ + L Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984 Query: 811 RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVA--ALEELAFKASEQIYGTPSSSPYEC 868 R L QE + +A L + G A ALE+ A E Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-------RLQNA 1037 Query: 869 LRQSCNILISTMNKLATAMQEGE-YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLED 927 L + + LA A+ E E D E + L AA ++ +LE+ Sbjct: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLR----GLEAAQIK-----------ELEE 1082 Query: 928 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRK 987 +K+LK+ L K +E + + A +A R E +LE +A + K Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGS-----------GAQSEAAGRTEPTGPKLEALRAEVSK 1131 Query: 988 KEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGA 1047 E++ ++ + + LEAE+A +R + T++G + S +A A Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSALA-SA 1188 Query: 1048 IPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVA 1107 A K Q++ R + + +NS++ + + S+ L+ Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGR---QEAERKNSLISSLEEEVSI-----LNRQ 1240 Query: 1108 KLSHEGPGSELP--AGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVA 1165 L EG EL A K+ +L E L L T S A S+ L E+V Sbjct: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQAET-----ASNSARAAERSSALREEVQ 1295 Query: 1166 QLKSLSDTVEKLKDEVLKETVSQ 1188 L+ ++ + + +E SQ Sbjct: 1296 SLREEAEKQRVASENLRQELTSQ 1318 Score = 87.8 bits (216), Expect = 6e-17 Identities = 206/1044 (19%), Positives = 407/1044 (38%), Gaps = 129/1044 (12%) Query: 203 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQL--------EQVQEWKSKMQEQQADLQR 254 ++ +L +K E+L ++ E + ++L+ K Q+ E+ + K++E + LQ+ Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 + +E +A + ++E+ A + A DK+ EE+ E LQ ++ L+E + + Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 L + K E+ QL+ L+++ A L+++ Q +++ L Sbjct: 397 LQDNPPQEKGEV-------LGDVLQLETLKQEAA----------TLAANNTQLQARVEML 439 Query: 375 MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTD-RNLNLEEK 433 ++ Q+ + +R +EE Q S I +L+ + A+E +E + L + Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499 Query: 434 VRELRETVGDLEAMNEMNDE----LQENARETELELREQLDMAGARVREAQKRVEAAQET 489 V L + L A + D+ L++ A+E + +L + L + + +VE + Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q +K+ A Q+ R+ QQ A+ +++ D +K E KA Sbjct: 560 LKQKEQQLKE----VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615 Query: 550 EMELRQMEVAQANR-----HMSLLTAFMPDSFL-RPGGDHDCVLVLLLMPRLICKAELIR 603 ++E+ Q ++ AN S+ A + L R + + + +A++ Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675 Query: 604 KQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK 663 + Q + E + +E+ + + L SL + + +L + + D + Sbjct: 676 LELQLRSE-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR----AADALE 730 Query: 664 KVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + E+ A RSL + K+ +E + L + Q L H AE E Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEAHQAE-TEVLR 786 Query: 724 MQLADHI---KFTQSALDCMSVEVGRLRAFLQGGQ--EATDIALL---LRDLETSCSDIR 775 +LA+ + +S + + EV R + Q EA A+ L L+ C R Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846 Query: 776 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 835 Q ++ + ++ G ++ + L Q ++ L + +L + +QE A +L L Sbjct: 847 QELQEAKEKVAGIES---HSELQISRQQNE-LAELHANLARALQQVQEKEVRAQKLADDL 902 Query: 836 AENEGLL------VAALEELAFKASEQ-------IYGTPSSS----PYECLRQSCNILIS 878 + + + VA LE L KA EQ + P+ + P Q S Sbjct: 903 STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962 Query: 879 TMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS 938 T A+Q E +AE+ ++ LRAA + E G + E+R +E+ + Sbjct: 963 TQ----AALQAMEREAEQMGNELE--RLRAALM-------ESQGQQQEERGQQEREVARL 1009 Query: 939 LKIKGE---ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + +G +L+ + LE +L +A + +Q L K++E + Sbjct: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAPGS 1055 A I +LE + +KQ +K+ E +G +A G Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKE---------------HASGSGAQSEAAGR 1114 Query: 1056 VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG 1115 G ++ A+R +S+L E K + SL A + Sbjct: 1115 TEPTG---------PKLEALRAEVSKL--EQQCQKQQEQADSLERSLEAERASRAERDSA 1163 Query: 1116 SELPAGALYRKTSQLLETLNQLST--------HTHVVDITRTSPAAKSPSAQLMEQVAQL 1167 E G L K +L + + L++ T V D ++ K+ A+ ++ + Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223 Query: 1168 KSLSDTVEKLKDEVLKETVSQRPG 1191 SL ++E+ + +L V ++ G Sbjct: 1224 NSLISSLEE-EVSILNRQVLEKEG 1246 Score = 85.9 bits (211), Expect = 2e-16 Identities = 192/926 (20%), Positives = 358/926 (38%), Gaps = 159/926 (17%) Query: 185 GAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 244 G V L + +E L A L+ ++E L +R + +AKL H E+ Q+ S Sbjct: 410 GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE--EEKQQLSSL 467 Query: 245 MQEQQADLQRRLKEARKEAKEALEAK-ERYMEEMADTADAIEMATLD------------- 290 + + Q+ + L +A++E ++A +A R ++A E+ TL+ Sbjct: 468 ITDLQSSISN-LSQAKEELEQASQAHGARLTAQVASLTS--ELTTLNATIQQQDQELAGL 524 Query: 291 KEMAEER----AESLQQEVEA---LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ- 342 K+ A+E+ A++LQQ+ +A L+ +V++L++ L+ + +++E A+ Q Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584 Query: 343 ----LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 398 EE+ A L++ ++ L + EK++ KL+ L Q+L+V + R+ Q ++Q Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKLEIL----QQQLQVANEARDSAQTSVTQ 640 Query: 399 AESTIDELKEQVD--------AALGAEEMVEMLTDRNLNL---EEKVRELRETVGDLEAM 447 A+ EL +V+ A E + + L L ++K E + + + Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700 Query: 448 NEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHL 507 E L+E+ + T+ L E+ A + E Q+ + E A+ + ++++++ L Sbjct: 701 QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI---SELKAETRSLVEQHKRERKEL 757 Query: 508 QDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANRHM 565 ++ + + + ET + + AE A E E Q+ EVA Sbjct: 758 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER- 816 Query: 566 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 625 + + +L+ E K QE E E + G+ Sbjct: 817 -----------YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESH 862 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYK---KVGSLYPEMSAHERSLDFL 682 + Q+S L+ L A L R + + V K + +L +M+A + + L Sbjct: 863 SELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919 Query: 683 IELLHK-DQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDC-- 739 L+ K + ET + E + + + QPE Q TQ+AL Sbjct: 920 ETLVRKAGEQQETASRELVKEPARAGD--------RQPEWLEEQQGRQFCSTQAALQAME 971 Query: 740 -----MSVEVGRLRAFL---------QGGQEATDIALLLRDLETSCSDIRQFCKKIRRRM 785 M E+ RLRA L + GQ+ ++A L ++ + +D+ Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADL----------- 1020 Query: 786 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 845 A A ++ + L + R + L LA+ GL A Sbjct: 1021 ----ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076 Query: 846 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 905 ++EL E LRQ+ L + K G + P Sbjct: 1077 IKEL-----------------EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119 Query: 906 LRAAALRAEIT-----------DAEGLGLKLE-------DRETVIKELKKSLKIKGEE-- 945 + ALRAE++ A+ L LE +R++ ++ L+ L+ K +E Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG 1179 Query: 946 -----LSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE--KEFEETMDA 998 L+ A L+ K+ +K DE +V +E + RK EE + Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE---RKNSLISSLEEEVSI 1236 Query: 999 LQADIDQLEAEKAELKQRLNSQSKRT 1024 L + + E E ELK+ + ++S+++ Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKS 1262 Score = 76.3 bits (186), Expect = 2e-13 Identities = 189/876 (21%), Positives = 334/876 (38%), Gaps = 114/876 (13%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKS----KMQEQQAD 251 +E+ +RAQ L + L TL+ K A ++ LE + + QE S K + D Sbjct: 889 QEKEVRAQ--KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD 946 Query: 252 LQRRLKEARK-----EAKEALEAKERYMEEMADTADAIEMATLDKE--MAEERAESLQQE 304 Q E ++ + AL+A ER E+M + + + A ++ + EER + ++E Sbjct: 947 RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ-ERE 1005 Query: 305 VEALKERVDELTTDLEILKA---EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 361 V L + DL + KA E+E + + L + + A L++AL Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNA------LNEQRVEFATLQEALAHALTEK 1059 Query: 362 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE--- 418 + QE KL+ L + +ELE +RQ ++L+E+L++ E A G E Sbjct: 1060 EGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG 1119 Query: 419 -MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELE-LREQLDMAGARV 476 +E L LE++ ++ +E LE E + R++ LE L+ QL+ + Sbjct: 1120 PKLEALRAEVSKLEQQCQKQQEQADSLERSLEA-ERASRAERDSALETLQGQLEEKAQEL 1178 Query: 477 REAQKRVEAAQETVADYQQTIKKYR--------QLTAHLQDVNRE----LTNQQEASVER 524 +Q + +AQ +A ++ ++ + Q+ Q+ R+ + ++E S+ Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238 Query: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 584 +Q E ++K K+ ++E R + + QA + A S LR Sbjct: 1239 RQVLEKEGESKELKRLVMAESEKSQKLEER-LRLLQAETASNSARAAERSSALRE----- 1292 Query: 585 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQ 644 + + +R++A+++ SEN LR Q A L L Q Sbjct: 1293 -------------EVQSLREEAEKQRVASEN------LRQELTSQAERAEELGQELKAWQ 1333 Query: 645 ATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAI 704 + E ALS ++ H + + ELL L + + E Sbjct: 1334 EKFFQKEQALSTLQLE--------------HTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379 Query: 705 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 764 ++ + L EQ + L + Q E+G L Q E A L Sbjct: 1380 RHREEL------EQSKQAAGGLRAELLRAQR-------ELGELIPLRQKVAEQERTAQQL 1426 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHL---------- 814 R + S ++ KK + + G+ G Q + LD + Sbjct: 1427 RAEKASYAEQLSMLKKAHGLL-AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485 Query: 815 ---TWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQ 871 T + V +E + A +L A+ EG V LEE E+ T E ++ Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545 Query: 872 SCNILISTMNK-LATAMQEGEYDAER---PPSKPPPVELRAAALRAEITDAEGLGLKLED 927 + ++K LA + Q + ++ ++ + A L+A++ + + + E Sbjct: 1546 EQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ 1605 Query: 928 RETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE-RIEKVQTRLEETQALLR 986 K + K + + N L + L+ K+ E R E + E QA L Sbjct: 1606 AAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL- 1664 Query: 987 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 1022 K KE E+T L A + LEA+ A Q+L K Sbjct: 1665 -KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699 Score = 69.3 bits (168), Expect = 2e-11 Identities = 80/356 (22%), Positives = 151/356 (42%), Gaps = 55/356 (15%) Query: 199 GLRAQV----RDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 GLRA++ R+L E L LR K AE + ++L K + K A+ R Sbjct: 1394 GLRAELLRAQRELGE-LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452 Query: 255 RLKEARKEAKEALE-----AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 L E ++ LE A+E+Y++E+A + AE R +Q+E ++ Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAV----------RADAETRLAEVQREAQSTA 1502 Query: 310 ERVDELTTDLEILKAEIEEKGS----DGAASSYQLKQLE----EQNARLKDALVRMRDLS 361 ++ +T E K ++ E+ + + Q++QLE EQ ++++ ++ D Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562 Query: 362 SSEKQEHVKLQKLMEK---KNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 + K + KL+ + + QE + ++ Q LQ +LSQ E + K Q++ A + Sbjct: 1563 QASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA---KT 1619 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 + +N L+E++R L E ++ ELR + + G +++ Sbjct: 1620 HYDAKKQQNQELQEQLRSL------------------EQLQKENKELRAEAERLGHELQQ 1661 Query: 479 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPPPE 531 A + + A++T ++ AH R+L Q +A R+ Q P+ Sbjct: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQ 1717 Score = 65.5 bits (158), Expect = 3e-10 Identities = 82/399 (20%), Positives = 178/399 (44%), Gaps = 37/399 (9%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI-QLEQVQEWKSKMQEQQADLQ 253 +E E + + LEE++ L + E + + KEL++ + + E+ Q+ + +++ QA+ Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 A + + E + EE A E + ERAE L QE++A +E+ Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF 1337 Query: 314 ELTTDLEILKAE-----------------IEEKGSDGAASSYQLKQLEEQNARLKDALVR 356 + L L+ E ++ ++ AA+ + ++ EQ+ + L Sbjct: 1338 QKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRA 1397 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG- 415 + E E + L++ + ++ + + +R ++ E+LS + L E+ + LG Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGE 1456 Query: 416 ----AEEMVEMLTDRNLNLEEKVRELRETVGDLEA-MNEMNDELQENARETELELREQLD 470 + +E+ D+ E+ V+EL D E + E+ E Q ARE E+ + Sbjct: 1457 RANLGRQFLEVELDQ--AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK--- 1511 Query: 471 MAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 527 GA+V+ E Q+ E Q+ A +Q R+ T +++++++L + +AS +QQ+ Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571 Query: 528 PPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 566 + + E++ A+ ++ +L +++ + + + Sbjct: 1572 LKA----VQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606 Score = 56.2 bits (134), Expect = 2e-07 Identities = 73/328 (22%), Positives = 133/328 (40%), Gaps = 73/328 (22%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----------------------KIQLEQ 237 LR +V + E + LR ++A +L L+K +++L+Q Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471 Query: 238 VQE-WKSKMQEQQADLQRRLKEARKEAK------------------EALEAKERYMEEMA 278 +E + ++ +AD + RL E ++EA+ + LE ++R+ EE Sbjct: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER- 1530 Query: 279 DTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 338 + T E E ++VE L +++ + ++ + +++ + G S Sbjct: 1531 ------QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584 Query: 339 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 398 + ++L+ Q L+ L + + EH KLQ MEK + +QQ + LQE+L Sbjct: 1585 EAQRLQAQLNELQAQLSQ-----KEQAAEHYKLQ--MEKAKTHYDAKKQQNQELQEQLRS 1637 Query: 399 AESTIDELKEQVDAA--LG------------AEEMVEMLTDRNLNLEEKVRELRETVGDL 444 E E KE A LG AE+ LT + +LE +V + + DL Sbjct: 1638 LEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL 1697 Query: 445 EAMNEMNDELQENARETELELREQLDMA 472 D L + E + + QLD++ Sbjct: 1698 GKFQVATDAL----KSREPQAKPQLDLS 1721 Score = 52.0 bits (123), Expect = 4e-06 Identities = 168/828 (20%), Positives = 313/828 (37%), Gaps = 106/828 (12%) Query: 285 EMATLDKEMAEERAESLQQEVEALKER--VDELTTDLEILKAEIE------EKGSDGAAS 336 +M L K++A+ER+ + E+E + R + E + +++ I+ EK + Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274 Query: 337 SYQLKQLEEQN----ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKN----------QEL 382 +L++L ++N RL + L + +DL + + Q K+ +L E+ L Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334 Query: 383 EVVRQQRERLQEELSQAESTIDELKEQVDAALGA--------EEMVEMLTDRNLNLEEKV 434 + ++ L EE S+A E + Q++ L A EE E+L + LEE + Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394 Query: 435 RELRETVGDLEAMNEMNDELQ-ENARETELELREQLDMAGARVREAQ-KRVEAAQETVAD 492 +L++ E + D LQ E ++ L ARV + +R + + +A+ Sbjct: 395 SQLQDNPPQ-EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453 Query: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 552 ++ +QL++ + D+ ++N +A E +Q + A + + Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513 Query: 553 LRQMEVAQA-------NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 ++Q + A + L G H V L L K + +++ Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ---VEQLSSSLKQKEQQLKEV 570 Query: 606 AQEK--------FELSENCSERPGL---RGAAGEQL-SFAAGLVYSLSLLQATLHRYEHA 653 A+++ +L+ ER R AA +QL + L +LQ L A Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630 Query: 654 LSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS- 712 V + E+S L +E ++Q + V L ++ Q + Sbjct: 631 RDSAQTSV-TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689 Query: 713 ----IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLE 768 +Q ++ L + +K T+ +L+ E R L+ Q + +L+ Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLE---EEKRRAADALEEQQRC------ISELK 740 Query: 769 TSCSDIRQFCKKIRRRMPGTDA--PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAA 826 + + K+ R+ + A G+ A L Q+ + H + +E+A Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARL---QQLGEA------HQAETEVLRRELAE 791 Query: 827 AAAQLIAPLAENEGLL--VAALEELAFKASEQ---IYGTPSSSPYECLRQSC----NILI 877 A A +E E L+ VAA E ++ S+Q YG L++ C L Sbjct: 792 AMAAQHTAESECEQLVKEVAAWRE-RYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ 850 Query: 878 STMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKK 937 K+A E R ++ + A ++ + E KL D + ++E Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE--- 907 Query: 938 SLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA--LLRKKEKEFEET 995 K S+ RL L +K + A + K R + Q L ++ ++F T Sbjct: 908 ----KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963 Query: 996 MDALQA---DIDQLEAEKAELKQRL-NSQSKRTIEGLRGPPPSGIATL 1039 ALQA + +Q+ E L+ L SQ ++ E RG +A L Sbjct: 964 QAALQAMEREAEQMGNELERLRAALMESQGQQQEE--RGQQEREVARL 1009 Score = 39.3 bits (90), Expect = 0.024 Identities = 96/467 (20%), Positives = 179/467 (38%), Gaps = 66/467 (14%) Query: 330 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 389 GS + L+ + Q RLK L R + E + +KL+ +K+ ++ +++Q+ Sbjct: 199 GSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258 Query: 390 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA--- 446 +RL + ++E +Q + L +E+ E L D+N +L ++ E + DL+ Sbjct: 259 DRL--------ALLNE--KQAASPLEPKEL-EELRDKNESLTMRLHETLKQCQDLKTEKS 307 Query: 447 --------MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 498 ++E N +L RE L++ D E K + E A ++ + Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367 Query: 499 KYRQLTAHLQDVNR----ELTNQQEASVERQQQPPPETFD----------FKIKFAETKA 544 Q L++ N +L+ +E + Q PP E + K + A A Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427 Query: 545 HAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK 604 + ++ + +E + + LL R + + + L+ L I Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAE-------RGHFEEEKQQLSSLITDL---QSSISN 477 Query: 605 QAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKK 664 +Q K EL E S+ G R A A L L+ L AT+ + + L+ +K Sbjct: 478 LSQAKEEL-EQASQAHGARLTAQ-----VASLTSELTTLNATIQQQDQELAGLKQQAKEK 531 Query: 665 VGSLYPEMSAHERS---LDFLIELL------HKDQLDETVNVEPLTKAIKYYQHLYSIHL 715 L + E++ L +E L + QL E + T+ H + Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR----QDHAQQLAT 587 Query: 716 AEQPEDCTMQLADHIKFTQSALDC-MSVEVGRLRAFLQGGQEATDIA 761 A + + +++ D AL+ + ++ L+ LQ EA D A Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 96.3 bits (238), Expect = 2e-19 Identities = 207/901 (22%), Positives = 356/901 (39%), Gaps = 112/901 (12%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLK----RAEDKAKLKELEKHKIQLEQ----VQEW 241 L ++ E R+ +E+LE LRL+ R + L+ E+ + LEQ ++ Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828 Query: 242 KSKMQEQQADLQRRL-------KEARKEAKEALEAKERYMEEMADTAD-----AIEMATL 289 +S++QEQ A L R+L ++AR+EA+ +EA ER E A A+++ Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888 Query: 290 DKE--MAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQN 347 ++E E A L+ E EAL+ + E+ L L+A E+ ++G A + L + Sbjct: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948 Query: 348 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR-------ERLQEELSQAE 400 A L+ ++ ++ +S +K+ + QKL++ + + +R+QR +RLQ E A Sbjct: 949 AGLRQQIIATQEKASLDKE--LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW 1006 Query: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 460 ++ + Q+ + L E E+L LE + EL E + L+ + L E+ ++ Sbjct: 1007 RELEAERAQLQSQL-QREQEELLA----RLEAEKEELSEEIAALQQERDEGLLLAESEKQ 1061 Query: 461 TELELREQLDMA------GAR-------------VREAQKRVEAAQETVADYQQTIKKYR 501 L L+E A G R R+AQ R E + TV Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV----------N 1111 Query: 502 QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQA 561 LT+ L+D+ + A + ++ + D + A+ + +LR +E A+ Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171 Query: 562 NRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQE-KFELSENCSERP 620 LL A LR + E+ R++A E + L E ER Sbjct: 1172 GLRRELLEA---QRKLRESQE---------------GREVQRQEAGELRRSLGEGAKERE 1213 Query: 621 GLRGAAGEQLSF---AAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHER 677 LR + E S A SL L + L + V K+ G L + ER Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273 Query: 678 S-LDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPED----CTMQLADHIKF 732 S L+ EL + + ++ E + + + L E+ E T+ L + Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333 Query: 733 TQSALDCM--SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDA 790 +++L+ M ++V + + Q G+ T LL LE + +Q R G + Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR----GLEL 1389 Query: 791 PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELA 850 + AA A ++ L + A E+A Q A A+ GL A L Sbjct: 1390 K-LEAARAEAAELGLRLSAAEGRAQGLEA---ELARVEVQRRAAEAQLGGLRSALRRGLG 1445 Query: 851 F-----KASEQIYGTPS-SSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV 904 A + G+P+ +P E + N ST+ + A P S Sbjct: 1446 LGRAPSPAPRPVPGSPARDAPAEGSGEGLN-SPSTLECSPGSQPPSPGPATSPASPDLDP 1504 Query: 905 ELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---D 961 E ALR + + + ++ T L + L E A R L+K + + Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564 Query: 962 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQS 1021 A + D R+ VQ L + +R+ E+E T+D + L+A ++EL+ S Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKIS 1624 Query: 1022 K 1022 K Sbjct: 1625 K 1625 Score = 91.7 bits (226), Expect = 4e-18 Identities = 192/877 (21%), Positives = 344/877 (39%), Gaps = 109/877 (12%) Query: 198 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLK 257 + +R + ++ L TLR + ++ +++ + LE+ QL+++++ + D QR ++ Sbjct: 536 QDMRGRYEASQDLLGTLRKQLSDSESERRALEE---QLQRLRDKTDGAMQAHEDAQREVQ 592 Query: 258 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTT 317 R A E E ++ A ++++A +++AE L+QE E L+ +EL Sbjct: 593 RLRS-------ANELLSREKSNLAHSLQVA-------QQQAEELRQEREKLQAAQEELRR 638 Query: 318 DLEILKAEIEEKGSDGA-------ASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 370 + L+ E E+ DGA S QL+QLE + + L LV +R+ S + Sbjct: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698 Query: 371 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 430 LQ EK + + + R++ ELS + +E Q D+ + E L L+L Sbjct: 699 LQ--AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ-DSLSKLSALNESLAQDKLDL 755 Query: 431 EEKVRELRETVGDLEAMNEMNDELQENARETE---LELREQLDMAGARVREAQKRVEAAQ 487 V +L E L+ ++ ARE + ELR + ++A + + + E AQ Sbjct: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815 Query: 488 ETVADYQQTIKKYR-QLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHA 546 E + T++ R QL L ++R+L+ +++ + ++ E + Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR--------------EAQRQV 861 Query: 547 KAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA 606 +A+E R+ E A A H L + R G L + + + L Q Sbjct: 862 EALERAAREKE-ALAKEHAGLAVQLVAAE--REGRTLSEEATRLRLEKEALEGSLFEVQR 918 Query: 607 QEKFELSENCSERPGLRGAAGEQLSFA--------AGLVYSLSLLQATLHRYEHALSQCS 658 Q L++ + R L A G+ L A AGL + Q + ++Q Sbjct: 919 Q----LAQLEARREQLE-AEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL 973 Query: 659 VDVYKKV-GSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAE 717 V ++ SL + +AHE L L + L ++ Q L Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEA 1033 Query: 718 QPEDCTMQLADHIKFTQSALD--CMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIR 775 + E +L++ I Q D + E + +A E T ++ L S + I Sbjct: 1034 EKE----ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089 Query: 776 QFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPL 835 ++ +R A + Q T+ L + A +E AAA AQ + L Sbjct: 1090 LEMERQKR-----------DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138 Query: 836 AENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAE 895 E L + +A E LR +L + L + E + Sbjct: 1139 QEQARDLGKQRDSCLREAEE-------------LRTQLRLLEDARDGLRRELLEAQRKLR 1185 Query: 896 RPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETVIKELKK---SLKIKGEELSE 948 A LR + + E L E+ + +K+ + SLK+ E+ + Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1245 Query: 949 ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEA 1008 +L+LLE+ + K+A E +Q +E ++ R++ +E M L ++ +L Sbjct: 1246 ---KLALLEEARTAVGKEAGELRTGLQ-EVERSRLEARRELQELRRQMKMLDSENTRLGR 1301 Query: 1009 EKAELKQRL------NSQSKRTIEGLRGPPPSGIATL 1039 E AEL+ RL +S+R GLR G A+L Sbjct: 1302 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338 Score = 75.1 bits (183), Expect = 4e-13 Identities = 191/924 (20%), Positives = 349/924 (37%), Gaps = 122/924 (13%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 +E E LR Q+R LE+ + LR + E + KL+E QE + +++ +L+R Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRES----------QEGREVQRQEAGELRR 1203 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES----LQQEVEALKE 310 L E KE EA R EE+ E + ++A E E L++ A+ + Sbjct: 1204 SLGEGAKER----EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259 Query: 311 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD-------LSSS 363 EL T L+ ++ E + Q+K L+ +N RL L ++ Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319 Query: 364 EKQEHVKLQKLMEKKNQELEVVRQQ----RERLQEELSQAESTIDELKEQVDAALGAE-E 418 ++E + L++ + K LEV+RQ+ + +LQE+ + + L ++ A G E + Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 ++ L LE E E L A L+ E++ R G +R Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRS 1438 Query: 479 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP---PETFDF 535 A +R + + + A + L + QPP P T Sbjct: 1439 ALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP- 1497 Query: 536 KIKFAETKAHAKAIEMELRQM--EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMP 593 A +A+ LR+ E+ A R L + Sbjct: 1498 ----ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTS-----------------ALN 1536 Query: 594 RLICKAELIRKQAQEKF-ELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEH 652 R + + E R A + +L + +E R + +LS G+ L+L + ++ R E Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEESVRRSER 1593 Query: 653 ALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYS 712 + ++D +V +L + A E L E + K + +ET +E + +K Sbjct: 1594 E-RRATLD---QVATLERSLQATESELRASQEKISKMKANET-KLEGDKRRLK------- 1641 Query: 713 IHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLLRDLETSC 771 + + E T++L + + L + + A Q Q+ D + + D E Sbjct: 1642 -EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA 1700 Query: 772 SDIRQFCKKIRRRMPGTDAP---------GIPAALAFGPQVSDTLLDCRKHLTWVVA--- 819 ++ +++ + + G+ ALA ++ D HL + Sbjct: 1701 GTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACE 1760 Query: 820 ----VLQEVAAAAAQLIAPLAENEGLL----------VAALEELAFKASEQIYGTPSSSP 865 VLQE AA Q ++ + L VA LE +A Q+ Sbjct: 1761 HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL-----QQL 1815 Query: 866 YECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKL 925 E LRQ + +N + E ER S ++ A L AE + E L+L Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGS----LQRALAQLEAEKREVERSALRL 1871 Query: 926 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA-- 983 E ++ ++ + E VRLS + +LD A+ + + Q ++++ +A Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931 Query: 984 -LLRKKEKEFEETMDA------LQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGI 1036 +L + + +DA LQ ++++L + +A+ ++ L ++ + + +RG + Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-V 1990 Query: 1037 ATLVSGIAGGAIPGQAPGSVP-GP 1059 +TL + AP S P GP Sbjct: 1991 STLKGQLQQELRRSSAPFSPPSGP 2014 Score = 70.1 bits (170), Expect = 1e-11 Identities = 98/439 (22%), Positives = 187/439 (42%), Gaps = 41/439 (9%) Query: 135 PASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPS 194 PA V G+ + P+ + G + PST +P + P P P TSP SP Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEG---LNSPSTLECSPGSQPPSPGPA-TSPA------SPD 1501 Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 + E +R +R+ ++L + + +R E + + L + ++E ++ + Q Sbjct: 1502 LDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVA 1561 Query: 255 RLKEARKEAKEAL---EAKERYMEEMADTADAIEMATLDKEMAEERA-ESLQQEVEALKE 310 +EAR+ L +A+ EE ++ ATLD+ ER+ ++ + E+ A +E Sbjct: 1562 ESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQE 1621 Query: 311 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR-DLSSSEKQEHV 369 ++ ++ + L+ + AS + +LE Q L+ L R R LS E Q Sbjct: 1622 KISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA 1681 Query: 370 ------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV----DAALGAEEM 419 LQ+ + + ++ ERL L++ E + L+++V +A + Sbjct: 1682 LQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741 Query: 420 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 479 + D+NL+L+ + L D + + E D AR+ E R+Q G Sbjct: 1742 LNSTRDKNLHLQ---KALTACEHDRQVLQERLDA----ARQALSEARKQSSSLG------ 1788 Query: 480 QKRVEAAQETVADYQ-QTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIK 538 ++V+ + VAD + Q ++ QL L++V R+ + A++ Q+ E + + Sbjct: 1789 -EQVQTLRGEVADLELQRVEAEGQL-QQLREVLRQRQEGEAAALNTVQKLQDERRLLQER 1846 Query: 539 FAETKAHAKAIEMELRQME 557 + +E E R++E Sbjct: 1847 LGSLQRALAQLEAEKREVE 1865 Score = 63.5 bits (153), Expect = 1e-09 Identities = 177/868 (20%), Positives = 343/868 (39%), Gaps = 115/868 (13%) Query: 178 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ 237 +PVL + L S +E + L+ ++ +E+ L R +R E K + + +LEQ Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQ 120 Query: 238 VQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER 297 + E Q E R ++++E + + EE A ++ ++ + Sbjct: 121 ALRLEPGELETQ--------EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL 172 Query: 298 AESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRM 357 + LQ ++ K+R EL L E+E+ Q + E + L+ AL+R+ Sbjct: 173 VQRLQGKILQYKKRCSELEQQLLERSGELEQ----------QRLRDTEHSQDLESALIRL 222 Query: 358 RD---LSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQEELSQAESTIDELK 407 + S+S Q + L++ +++ ++++ V R ++EL E+ + Sbjct: 223 EEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282 Query: 408 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ---ENARETELE 464 E +A E R L L +V R V +++ E D LQ E AR + Sbjct: 283 ESFNAYFSNEH------SRLLLLWRQVVGFRRLVSEVKMFTE-RDLLQLGGELARTSRAV 335 Query: 465 LREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVER 524 L ++ +R A+ R EAA ++K L A L++ R+ +++ ++ Sbjct: 336 QEAGLGLS-TGLRLAESRAEAA----------LEKQALLQAQLEEQLRDKVLREKDLAQQ 384 Query: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHD 584 Q Q + D + E K +E + +E Q N+ ++ + L+ + Sbjct: 385 QMQSDLDKADLSARVTELGLAVKRLEKQ--NLEKDQVNKDLTEKLEALESLRLQEQAALE 442 Query: 585 CVLVLLLMPRLICKAELIRKQAQEKFELSENCSERP------GLRGAAGEQL-------- 630 L L A+ + ++ +LS SER LRG +G++ Sbjct: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSG--SERTADASNGSLRGLSGQRTPSPPRRSS 500 Query: 631 -----------SFAAGLVYSLSLLQATLHRYEHALS------QCSVDVYKKVGSLYPEMS 673 S A +L+L+ + LH+ + + + S D+ + + Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560 Query: 674 AHERSLDFLIELLHKDQLDETVNV-EPLTKAIKYYQHLYSIHLAEQPE-----DCTMQLA 727 + R+L+ ++ L +D+ D + E + ++ + + E+ Q A Sbjct: 561 SERRALEEQLQRL-RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA 619 Query: 728 DHIKFTQSALDCMSVEVGRLRAFLQGGQE--ATDIALLLRDLETSCSDIRQFCKKIRRRM 785 + ++ + L E+ R R L+ QE D A + R+LE S + Q + +R + Sbjct: 620 EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL--EGKRSV 677 Query: 786 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 845 + + AL+ D L A EVA A + A E E ++ Sbjct: 678 LAKELVEVREALSRATLQRDML----------QAEKAEVAEALTKAEAGRVELE---LSM 724 Query: 846 LEELAFKASEQIYGTPSSSPYECLRQ---SCNILISTMNKLATAMQEGEYDAERPPSKPP 902 + A +AS Q + S+ E L Q N L++ + + +A+Q + AE+ + Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784 Query: 903 PVELRAAALRAEITDA-EGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLD 961 + R LR E A +GL L E + L++ L E S+ +L+ L ++L Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844 Query: 962 SAAKDADERIEKVQTRLEETQALLRKKE 989 ++ ++ + Q ++E + R+KE Sbjct: 845 GREQELEQARREAQRQVEALERAAREKE 872 Score = 47.8 bits (112), Expect = 7e-05 Identities = 193/934 (20%), Positives = 353/934 (37%), Gaps = 149/934 (15%) Query: 303 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 362 QEVE E V + T + +L +EKG GA Q Q+ A +++ + R +LS Sbjct: 9 QEVELTLETVIQ-TLESSVL---CQEKGL-GARDLAQDAQITSLPALIREIVTR--NLSQ 61 Query: 363 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 422 E + ++ L ++++ + LQ+ELS+ E + + + + D V Sbjct: 62 PESPVLLPATEMAS-----LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSE 116 Query: 423 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 482 ++ L LE E +E G + E+ +LQE +L+ + + R+AQ Sbjct: 117 RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE---GQQRQAQ-L 172 Query: 483 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 542 V+ Q + Y+ K+ +L L + + EL Q+ E Q + + + Sbjct: 173 VQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229 Query: 543 KAHAKAIEMELRQMEVA-QANRHMSLLTAFMPDSFLRP---------------------- 579 + A+ M Q++ A AN+ +S + + + R Sbjct: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289 Query: 580 GGDHDCVLVL----LLMPRLICKAELIRK----QAQEKFELSENCSERPGLRGAAGEQL- 630 +H +L+L + RL+ + ++ + Q + + + GL + G +L Sbjct: 290 SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349 Query: 631 -SFAAGLVYSLSLLQA---------TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 S A + +LLQA L + A Q D+ K ++SA L Sbjct: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK------ADLSARVTELG 403 Query: 681 FLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCM 740 ++ L K L++ + LT+ + + L S+ L EQ ++ D Q+ D Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKL---EALESLRLQEQ---AALETEDGEGLQQTLRDL- 456 Query: 741 SVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFG 800 +A L + ++ R + S +R + P +PG + G Sbjct: 457 ------AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510 Query: 801 PQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGT 860 P + C T L + +A + + + G ++AS+ + GT Sbjct: 511 PSPA-----CSDSST-----LALIHSALHKRQLQVQDMRG---------RYEASQDLLGT 551 Query: 861 --PSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAA---ALRAEI 915 S E R++ + + + DA+R + LR+A R + Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQR-----LRSANELLSREKS 606 Query: 916 TDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDAD------E 969 A L + + E + +E +K L+ EEL R LE++ + A +D E Sbjct: 607 NLAHSLQVAQQQAEELRQEREK-LQAAQEELRRQRDR---LEEEQEDAVQDGARVRRELE 662 Query: 970 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 R + +LE +++L K+ E E + D L+AEKAE+ + L +E Sbjct: 663 RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE--- 719 Query: 1030 GPPPSGIATLVSGIAGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSIL 1089 +S A S+ + +S L ++ RL ++QL+ E S L Sbjct: 720 --------LELSMTKLRAEEASLQDSLSKLSALNES-LAQDKLDLNRL-VAQLEEEKSAL 769 Query: 1090 KG----AQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD 1145 +G A+ +A++A + +L E + R Q E L Q Sbjct: 770 QGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ--------- 820 Query: 1146 ITRTSPAAKSPSAQLMEQVAQL-KSLSDTVEKLK 1178 P + +QL EQ+AQL + LS ++L+ Sbjct: 821 ---QLPTLRHERSQLQEQLAQLSRQLSGREQELE 851 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 95.9 bits (237), Expect = 2e-19 Identities = 213/1056 (20%), Positives = 422/1056 (39%), Gaps = 136/1056 (12%) Query: 195 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 249 KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++ Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ + Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991 Query: 310 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 369 ++ ++L+ + ++L+ I + ++ A + K L + + + + + E++ Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051 Query: 370 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 +L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 +K+REL + DL+ + + A + + +L E+L+ + +E ++ Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 A Q+ K Q L+ E T EA V+ +Q HA+A+ Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205 Query: 550 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 596 E +L Q + A+AN + T ++ L + +H + + L Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265 Query: 597 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 651 K E R + +K +N E L A G+ + A + S LQ T + Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325 Query: 652 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 708 Q ++V K+ L E ++ + LD E+ K L+ T+N++ K Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382 Query: 709 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 764 ++ E+ + + L + +A D + RL+ QE D+ + Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 DL+ + KK R+ D LL K+++ A ++ Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473 Query: 825 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 868 A A A+ E + L +A E A +A E++ T E Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 928 L +S L + M ++ T ++E E + + +E+ AL+ + L + E Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587 Query: 929 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 985 E ++L++ L EL + + +L +KKL+ KD + + + EE L Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647 Query: 986 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1042 RK + K+F+ ++ +A D++ A E +++ S ++ + A + Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707 Query: 1043 IAGGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKASLASL 1101 + + + S+ G ++D L+ +I+ + + + Q + KA+ Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---- 1763 Query: 1102 PPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTSPAAKS 1155 +LS+E A QL +L + H ++ T A ++ Sbjct: 1764 --QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821 Query: 1156 PSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1188 AQL EQV A+ K + K KD+ LKE + Q Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857 Score = 80.5 bits (197), Expect = 9e-15 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%) Query: 210 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 268 KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887 Query: 269 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 328 K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933 Query: 329 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 388 + G + K++ +Q L++ L + E V + ++K E+ V+ Q Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993 Query: 389 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 436 +L +E E I + L E+ + A E M+ L R L EEK R+ Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052 Query: 437 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492 R+ GD +E +LQ E +++L + + E Q + + +A Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105 Query: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 550 +KK R+L H+ D+ +L +++ A E+Q++ E + E + A + Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165 Query: 551 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 610 ELR A+ + +++L + + H+ + E+ +K AQ Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206 Query: 611 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 666 EL+E + + + A L L +L EH + V + Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263 Query: 667 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 721 L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321 Query: 722 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 765 +Q K S L + E L+ L EA +D L+ Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381 Query: 766 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 825 D ++ + + K+ ++ + A A+ D L + L QE+ Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430 Query: 826 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 884 L +N+ LV+ LE+ K + + + SS Y R A Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 ++ +A + +E L+AE+ D L +D + EL+KS + Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1003 ++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ + Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598 Query: 1004 DQLEAE-KAELKQR-LNSQSKRTIEG 1027 + E E + E KQR L + +K+ +EG Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624 Score = 79.3 bits (194), Expect = 2e-14 Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 249 +K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+ Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++ Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198 Query: 310 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 351 ++ V+ELT LE K +E++ +D A L Q +E + +L+ Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258 Query: 352 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 411 + ++ S ++ +L + K E+E V + + + + L Q+ Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318 Query: 412 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471 +E+++ T + LN+ K+R+L E L+ + E ++N L QL Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 513 + ++++ VEA +E +Q+ I+ Q L L D+ + Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435 Query: 514 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 565 L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491 Query: 566 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 625 L L K EL R K E+ + S + + Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 E L + ++ L E L Q + D L E++ F +L Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 745 +D+ +E + ++ H Y L ++ + + A K D Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635 Query: 746 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 803 ++ + ++ + ++D + D R +I + A + A L + Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695 Query: 804 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 863 RK L E A++ L + + L A + +L + E+ + Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755 Query: 864 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 923 S + +R++ N+LAT A++ S +E + LR+++ + EG + Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808 Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 983 K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+ Sbjct: 1809 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1861 Query: 984 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 1023 RK ++++E + A + QL+ E E QR+N+ ++ Sbjct: 1862 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1902 Score = 76.6 bits (187), Expect = 1e-13 Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 318 K+AK + E++A A + A L+K E+AEE A SL AL++ L Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737 Query: 319 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 378 + L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++ Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793 Query: 379 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 ++L+E + +E +M + + +EQ + ARV++ ++++E A+E Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1891 Query: 494 QQTIKKYRQLTAHLQDVNRELTNQQEAS 521 + +++ A+ + + REL E++ Sbjct: 1892 -----ESQRINANRRKLQRELDEATESN 1914 Score = 75.5 bits (184), Expect = 3e-13 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 238 V L S + E RA++ D KL+ T L AE KA KL K++ QL+ Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 298 QE + Q+ ++ +L++ +E + + ME + I + ++++ Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380 Query: 299 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 358 + VEAL+E ++E L + EEK + +L+++ L L R Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500 Query: 419 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 465 +E T++ L E + V EL ++ LE M EM +L+E E EL+ Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 E + V + + ++ A +Q +K RQL L + EL + ER+ Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 585 Q+ A A K +E +L+ +E+ DS ++ G + Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643 Query: 586 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 642 + +L + QAQ K EL + + R + A E A L L Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691 Query: 643 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 696 LQ L E A Q ++ + L +S +R L+ I L ++ +E N Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751 Query: 697 VEPLTKAIK 705 +E ++ ++ Sbjct: 1752 MEAMSDRVR 1760 Score = 64.3 bits (155), Expect = 7e-10 Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%) Query: 181 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 236 L + A+ K+ L+AQ++D + +LE R R E A KE EK LE Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690 Query: 237 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 276 Q+QE ++ +QADL++ + A ++ K LEA+ +EE Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750 Query: 277 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 307 M +D + AT L E+A ER+ ES +Q++E Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810 Query: 308 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366 K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++ Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1863 Query: 367 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 426 + ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1919 Query: 427 NLN-LEEKVRELRET 440 +N L+ K+R ET Sbjct: 1920 EVNALKSKLRRGNET 1934 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 95.9 bits (237), Expect = 2e-19 Identities = 213/1056 (20%), Positives = 422/1056 (39%), Gaps = 136/1056 (12%) Query: 195 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 249 KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++ Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ + Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998 Query: 310 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 369 ++ ++L+ + ++L+ I + ++ A + K L + + + + + E++ Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058 Query: 370 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 +L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 +K+REL + DL+ + + A + + +L E+L+ + +E ++ Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 A Q+ K Q L+ E T EA V+ +Q HA+A+ Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212 Query: 550 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 596 E +L Q + A+AN + T ++ L + +H + + L Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272 Query: 597 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 651 K E R + +K +N E L A G+ + A + S LQ T + Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332 Query: 652 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 708 Q ++V K+ L E ++ + LD E+ K L+ T+N++ K Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 709 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 764 ++ E+ + + L + +A D + RL+ QE D+ + Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 DL+ + KK R+ D LL K+++ A ++ Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480 Query: 825 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 868 A A A+ E + L +A E A +A E++ T E Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 928 L +S L + M ++ T ++E E + + +E+ AL+ + L + E Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594 Query: 929 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 985 E ++L++ L EL + + +L +KKL+ KD + + + EE L Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654 Query: 986 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1042 RK + K+F+ ++ +A D++ A E +++ S ++ + A + Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714 Query: 1043 IAGGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKASLASL 1101 + + + S+ G ++D L+ +I+ + + + Q + KA+ Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---- 1770 Query: 1102 PPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTSPAAKS 1155 +LS+E A QL +L + H ++ T A ++ Sbjct: 1771 --QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828 Query: 1156 PSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1188 AQL EQV A+ K + K KD+ LKE + Q Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864 Score = 80.5 bits (197), Expect = 9e-15 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%) Query: 210 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 268 KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894 Query: 269 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 328 K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940 Query: 329 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 388 + G + K++ +Q L++ L + E V + ++K E+ V+ Q Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000 Query: 389 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 436 +L +E E I + L E+ + A E M+ L R L EEK R+ Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059 Query: 437 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492 R+ GD +E +LQ E +++L + + E Q + + +A Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112 Query: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 550 +KK R+L H+ D+ +L +++ A E+Q++ E + E + A + Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172 Query: 551 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 610 ELR A+ + +++L + + H+ + E+ +K AQ Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213 Query: 611 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 666 EL+E + + + A L L +L EH + V + Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270 Query: 667 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 721 L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328 Query: 722 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 765 +Q K S L + E L+ L EA +D L+ Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388 Query: 766 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 825 D ++ + + K+ ++ + A A+ D L + L QE+ Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437 Query: 826 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 884 L +N+ LV+ LE+ K + + + SS Y R A Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 ++ +A + +E L+AE+ D L +D + EL+KS + Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1003 ++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ + Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605 Query: 1004 DQLEAE-KAELKQR-LNSQSKRTIEG 1027 + E E + E KQR L + +K+ +EG Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631 Score = 79.3 bits (194), Expect = 2e-14 Identities = 166/883 (18%), Positives = 352/883 (39%), Gaps = 119/883 (13%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 249 +K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+ Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++ Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205 Query: 310 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 351 ++ V+ELT LE K +E++ +D A L Q +E + +L+ Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265 Query: 352 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 411 + ++ S ++ +L + K E+E V + + + + L Q+ Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 412 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471 +E+++ T + LN+ K+R+L E L+ + E ++N L QL Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 513 + ++++ VEA +E +Q+ I+ Q L L D+ + Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442 Query: 514 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 565 L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498 Query: 566 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 625 L L K EL R K E+ + S + + Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 E L + ++ L E L Q + D L E++ F +L Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 745 +D+ +E + ++ H Y L ++ + + A K D Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642 Query: 746 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 803 ++ + ++ + ++D + D R +I + A + A L + Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702 Query: 804 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 863 RK L E A++ L + + L A + +L + E+ + Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762 Query: 864 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 923 S + +R++ N+LAT A++ S +E + LR+++ + EG + Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815 Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 983 K + + T+ +L+ K +L E + + ++ + K D++++++ ++E+ Sbjct: 1816 KSKFKSTI-----AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-- 1868 Query: 984 LLRKKEKEFEETMDALQADIDQLE---AEKAELKQRLNSQSKR 1023 RK ++++E + A + QL+ E E QR+N+ ++ Sbjct: 1869 --RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRK 1909 Score = 76.6 bits (187), Expect = 1e-13 Identities = 76/328 (23%), Positives = 160/328 (48%), Gaps = 41/328 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 318 K+AK + E++A A + A L+K E+AEE A SL AL++ L Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744 Query: 319 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 378 + L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++ Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800 Query: 379 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 ++L+E + +E +M + + +EQ + ARV++ ++++E A+E Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEE----- 1898 Query: 494 QQTIKKYRQLTAHLQDVNRELTNQQEAS 521 + +++ A+ + + REL E++ Sbjct: 1899 -----ESQRINANRRKLQRELDEATESN 1921 Score = 75.5 bits (184), Expect = 3e-13 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 238 V L S + E RA++ D KL+ T L AE KA KL K++ QL+ Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 298 QE + Q+ ++ +L++ +E + + ME + I + ++++ Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387 Query: 299 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 358 + VEAL+E ++E L + EEK + +L+++ L L R Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507 Query: 419 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 465 +E T++ L E + V EL ++ LE M EM +L+E E EL+ Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 E + V + + ++ A +Q +K RQL L + EL + ER+ Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 585 Q+ A A K +E +L+ +E+ DS ++ G + Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650 Query: 586 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 642 + +L + QAQ K EL + + R + A E A L L Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698 Query: 643 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 696 LQ L E A Q ++ + L +S +R L+ I L ++ +E N Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758 Query: 697 VEPLTKAIK 705 +E ++ ++ Sbjct: 1759 MEAMSDRVR 1767 Score = 64.3 bits (155), Expect = 7e-10 Identities = 77/315 (24%), Positives = 142/315 (45%), Gaps = 66/315 (20%) Query: 181 LTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE---- 236 L + A+ K+ L+AQ++D + +LE R R E A KE EK LE Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697 Query: 237 QVQE--WKSKMQEQQADLQRRL-----------KEARKEAKEALEAKERYMEE------- 276 Q+QE ++ +QADL++ + A ++ K LEA+ +EE Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757 Query: 277 -MADTADAIEMAT-----LDKEMAEERA-----ESLQQEVEA------------------ 307 M +D + AT L E+A ER+ ES +Q++E Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817 Query: 308 -LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366 K + L + L+ ++E++ + A++ LKQ ++ +LK+ L+++ D E++ Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ---KDKKLKEILLQVED----ERK 1870 Query: 367 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 426 + ++ EK N ++ +++Q E +EE + + +L+ ++D A + E + R Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM----GR 1926 Query: 427 NLN-LEEKVRELRET 440 +N L+ K+R ET Sbjct: 1927 EVNALKSKLRRGNET 1941 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 95.9 bits (237), Expect = 2e-19 Identities = 213/1056 (20%), Positives = 422/1056 (39%), Gaps = 136/1056 (12%) Query: 195 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 249 KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++ Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ + Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 998 Query: 310 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 369 ++ ++L+ + ++L+ I + ++ A + K L + + + + + E++ Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058 Query: 370 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 +L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1115 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 +K+REL + DL+ + + A + + +L E+L+ + +E ++ Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1168 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 A Q+ K Q L+ E T EA V+ +Q HA+A+ Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1212 Query: 550 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 596 E +L Q + A+AN + T ++ L + +H + + L Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272 Query: 597 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 651 K E R + +K +N E L A G+ + A + S LQ T + Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332 Query: 652 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 708 Q ++V K+ L E ++ + LD E+ K L+ T+N++ K Sbjct: 1333 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 709 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 764 ++ E+ + + L + +A D + RL+ QE D+ + Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1441 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 DL+ + KK R+ D LL K+++ A ++ Sbjct: 1442 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1480 Query: 825 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 868 A A A+ E + L +A E A +A E++ T E Sbjct: 1481 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 928 L +S L + M ++ T ++E E + + +E+ AL+ + L + E Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1594 Query: 929 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 985 E ++L++ L EL + + +L +KKL+ KD + + + EE L Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654 Query: 986 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1042 RK + K+F+ ++ +A D++ A E +++ S ++ + A + Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714 Query: 1043 IAGGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKASLASL 1101 + + + S+ G ++D L+ +I+ + + + Q + KA+ Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---- 1770 Query: 1102 PPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTSPAAKS 1155 +LS+E A QL +L + H ++ T A ++ Sbjct: 1771 --QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828 Query: 1156 PSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1188 AQL EQV A+ K + K KD+ LKE + Q Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864 Score = 85.1 bits (209), Expect = 4e-16 Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 249 +K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+ Sbjct: 1093 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++ Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1205 Query: 310 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 351 ++ V+ELT LE K +E++ +D A L Q +E + +L+ Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265 Query: 352 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 411 + ++ S ++ +L + K E+E V + + + + L Q+ Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 412 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471 +E+++ T + LN+ K+R+L E L+ + E ++N L QL Sbjct: 1326 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 513 + ++++ VEA +E +Q+ I+ Q L L D+ + Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442 Query: 514 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 565 L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1498 Query: 566 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 625 L L K EL R K E+ + S + + Sbjct: 1499 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 E L + ++ L E L Q + D L E++ F +L Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1587 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 745 +D+ +E + ++ H Y L ++ + + A K D Sbjct: 1588 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642 Query: 746 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 803 ++ + ++ + ++D + D R +I + A + A L + Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702 Query: 804 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 863 RK L E A++ L + + L A + +L + E+ + Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762 Query: 864 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 923 S + +R++ N+LAT A++ S +E + LR+++ + EG + Sbjct: 1763 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1815 Query: 924 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 967 K + + T+ I +L++ ++ + E A L +KKL A+ Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875 Query: 968 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 1024 E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ + Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1934 Query: 1025 IEGLRGPPP 1033 LRGPPP Sbjct: 1935 ---LRGPPP 1940 Score = 81.3 bits (199), Expect = 5e-15 Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE Sbjct: 1629 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 318 K+AK + E++A A + A L+K E+AEE A SL AL++ L Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1744 Query: 319 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 378 + L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++ Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1800 Query: 379 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1854 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 ++L+E + +E +M + + +EQ + ARV++ ++++E A+E Sbjct: 1855 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903 Query: 494 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 531 +K ++ + N + + A + + PPP+ Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1941 Score = 80.5 bits (197), Expect = 9e-15 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%) Query: 210 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 268 KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894 Query: 269 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 328 K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE Sbjct: 895 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 940 Query: 329 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 388 + G + K++ +Q L++ L + E V + ++K E+ V+ Q Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000 Query: 389 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 436 +L +E E I + L E+ + A E M+ L R L EEK R+ Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1059 Query: 437 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492 R+ GD +E +LQ E +++L + + E Q + + +A Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1112 Query: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 550 +KK R+L H+ D+ +L +++ A E+Q++ E + E + A + Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172 Query: 551 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 610 ELR A+ + +++L + + H+ + E+ +K AQ Sbjct: 1173 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1213 Query: 611 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 666 EL+E + + + A L L +L EH + V + Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1270 Query: 667 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 721 L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328 Query: 722 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 765 +Q K S L + E L+ L EA +D L+ Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388 Query: 766 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 825 D ++ + + K+ ++ + A A+ D L + L QE+ Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1437 Query: 826 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 884 L +N+ LV+ LE+ K + + + SS Y R A Sbjct: 1438 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 ++ +A + +E L+AE+ D L +D + EL+KS + Sbjct: 1493 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1546 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1003 ++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ + Sbjct: 1547 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605 Query: 1004 DQLEAE-KAELKQR-LNSQSKRTIEG 1027 + E E + E KQR L + +K+ +EG Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEG 1631 Score = 75.5 bits (184), Expect = 3e-13 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 238 V L S + E RA++ D KL+ T L AE KA KL K++ QL+ Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 298 QE + Q+ ++ +L++ +E + + ME + I + ++++ Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387 Query: 299 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 358 + VEAL+E ++E L + EEK + +L+++ L L R Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507 Query: 419 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 465 +E T++ L E + V EL ++ LE M EM +L+E E EL+ Sbjct: 1508 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1564 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 E + V + + ++ A +Q +K RQL L + EL + ER+ Sbjct: 1565 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1617 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 585 Q+ A A K +E +L+ +E+ DS ++ G + Sbjct: 1618 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1650 Query: 586 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 642 + +L + QAQ K EL + + R + A E A L L Sbjct: 1651 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698 Query: 643 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 696 LQ L E A Q ++ + L +S +R L+ I L ++ +E N Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758 Query: 697 VEPLTKAIK 705 +E ++ ++ Sbjct: 1759 MEAMSDRVR 1767 Score = 33.5 bits (75), Expect = 1.3 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%) Query: 186 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 245 A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++ Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1903 Query: 246 QEQQADLQRRLKEARKEAKEAL 267 + LQR L EA E+ EA+ Sbjct: 1904 NANRRKLQRELDEA-TESNEAM 1924 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 95.9 bits (237), Expect = 2e-19 Identities = 213/1056 (20%), Positives = 422/1056 (39%), Gaps = 136/1056 (12%) Query: 195 KEEEGLRAQVRD----LEEKLETLRLKRAEDKAKLKELEKHKIQLEQV-QEWKSKMQEQQ 249 KE E +Q+ + L+E+L+ AE + L K +LE++ E +++++E++ Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 Q+ E +K A++ L+ +E+ EE A A + L+K AE + + L+ E+ + Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEA----ARQKLQLEKVTAEAKIKKLEDEILVMD 991 Query: 310 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV 369 ++ ++L+ + ++L+ I + ++ A + K L + + + + + E++ Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051 Query: 370 KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 +L+KL K + +Q LQ ++++ + + + +E++ AAL + + + +N N Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA--RLDDEIAQKN-N 1108 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 +K+REL + DL+ + + A + + +L E+L+ + +E ++ Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-------ALKTELEDTLDS 1161 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 A Q+ K Q L+ E T EA V+ +Q HA+A+ Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ----------------KHAQAV 1205 Query: 550 E---MELRQMEVAQANRHMSLLTAFMPDSFL----------RPGGDHDCVLVLLLMPRLI 596 E +L Q + A+AN + T ++ L + +H + + L Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265 Query: 597 CK---AELIRKQAQEKFELSENCSERPG--LRGAAGEQLSFAAGLVYSLSLLQATLHRYE 651 K E R + +K +N E L A G+ + A + S LQ T + Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325 Query: 652 HALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLD---ETVNVEPLTKAIKYYQ 708 Q ++V K+ L E ++ + LD E+ K L+ T+N++ K Sbjct: 1326 EETRQ-KLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLERHISTLNIQLSDSKKKLQD 1382 Query: 709 HLYSIHLAEQPEDCTMQ----LADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLL 764 ++ E+ + + L + +A D + RL+ QE D+ + Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ------QELDDLVV-- 1434 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 DL+ + KK R+ D LL K+++ A ++ Sbjct: 1435 -DLDNQRQLVSNLEKKQRK--------------------FDQLLAEEKNISSKYADERDR 1473 Query: 825 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC---------------- 868 A A A+ E + L +A E A +A E++ T E Sbjct: 1474 AEAEAR----EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDR 928 L +S L + M ++ T ++E E + + +E+ AL+ + L + E Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQN 1587 Query: 929 ETVIKELKKSLKIKGEELSEANVRLSL---LEKKLDSAAKDADERIEKVQTRLEETQALL 985 E ++L++ L EL + + +L +KKL+ KD + + + EE L Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647 Query: 986 RKKE---KEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSG 1042 RK + K+F+ ++ +A D++ A E +++ S ++ + A + Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707 Query: 1043 IAGGAIPGQAPGSVPGPGLVKDSPLLLQ-QISAMRLHISQLQHENSILKGAQMKASLASL 1101 + + + S+ G ++D L+ +I+ + + + Q + KA+ Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---- 1763 Query: 1102 PPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVD------ITRTSPAAKS 1155 +LS+E A QL +L + H ++ T A ++ Sbjct: 1764 --QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821 Query: 1156 PSAQLMEQV---AQLKSLSDTVEKLKDEVLKETVSQ 1188 AQL EQV A+ K + K KD+ LKE + Q Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857 Score = 85.1 bits (209), Expect = 4e-16 Identities = 174/909 (19%), Positives = 356/909 (39%), Gaps = 130/909 (14%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQ 249 +K+EE L+A + L++++ ++ K++ELE H + L+ + ++K ++Q+ Sbjct: 1086 AKKEEELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 DL L+ + E ++ L++ E A + T+ K+ +E S + +V+ ++ Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEV---TVLKKALDEETRSHEAQVQEMR 1198 Query: 310 ER----VDELTTDLEILKAE----------IEEKGSDGAASSYQLKQ----LEEQNARLK 351 ++ V+ELT LE K +E++ +D A L Q +E + +L+ Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258 Query: 352 DALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVD 411 + ++ S ++ +L + K E+E V + + + + L Q+ Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318 Query: 412 AALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471 +E+++ T + LN+ K+R+L E L+ + E ++N L QL Sbjct: 1319 ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQ------------------LTAHLQDVNRE 513 + ++++ VEA +E +Q+ I+ Q L L D+ + Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435 Query: 514 LTNQQE--ASVERQQ----QPPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHM 565 L NQ++ +++E++Q Q E + K+A+ +A A+A E E + + +A+A Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA---- 1491 Query: 566 SLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGA 625 L L K EL R K E+ + S + + Sbjct: 1492 -------------------------LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 E L + ++ L E L Q + D L E++ F +L Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDEL-QATED-----AKLRLEVNMQALKGQFERDL 1580 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 745 +D+ +E + ++ H Y L ++ + + A K D Sbjct: 1581 QARDEQNEEKR-----RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635 Query: 746 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD--APGIPAALAFGPQV 803 ++ + ++ + ++D + D R +I + A + A L + Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695 Query: 804 SDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 863 RK L E A++ L + + L A + +L + E+ + Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755 Query: 864 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 923 S + +R++ N+LAT A++ S +E + LR+++ + EG + Sbjct: 1756 S--DRVRKATQQAEQLSNELATERS----TAQKNESARQQLERQNKELRSKLHEMEG-AV 1808 Query: 924 KLEDRETV------IKELKKSLKIKGEELSEANVRLSLLEKKLD----------SAAKDA 967 K + + T+ I +L++ ++ + E A L +KKL A+ Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868 Query: 968 DERIEKVQTRLEETQALLRKKEKEFEE---TMDALQADIDQLEAEKAELKQRLNSQSKRT 1024 E+ EK R+++ + L + E+E + LQ ++D+ + + +N+ + Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK- 1927 Query: 1025 IEGLRGPPP 1033 LRGPPP Sbjct: 1928 ---LRGPPP 1933 Score = 81.3 bits (199), Expect = 5e-15 Identities = 77/338 (22%), Positives = 161/338 (47%), Gaps = 31/338 (9%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 L ++DLE + ++ R E +K+L K + Q++ Q + + ++ KE Sbjct: 1622 LEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDK-EMAEERAESLQQEVEALKERVDELTTD 318 K+AK + E++A A + A L+K E+AEE A SL AL++ L Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEAR 1737 Query: 319 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 378 + L+ E+EE+ + A S ++++ +Q +L + L R S+++K E + Q +E++ Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER--STAQKNESARQQ--LERQ 1793 Query: 379 NQEL-----EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 N+EL E+ + + + ++ E+ I +L+EQV+ ++ +L++K Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA------TKSLKQK 1847 Query: 434 VRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADY 493 ++L+E + +E +M + + +EQ + ARV++ ++++E A+E Sbjct: 1848 DKKLKEILLQVEDERKMAE-----------QYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896 Query: 494 QQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 531 +K ++ + N + + A + + PPP+ Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQ 1934 Score = 80.5 bits (197), Expect = 9e-15 Identities = 184/866 (21%), Positives = 341/866 (39%), Gaps = 117/866 (13%) Query: 210 KLETLRLKRAEDKAK-LKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALE 268 KL + R K K L ++ + + +++ ++ K +E+Q + LKE ++ + E Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887 Query: 269 AKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEE 328 K E++ + E+ E AE ++ + A K+ ++E+ ++E A +EE Sbjct: 888 EKNLLQEQL----------QAETELYAE-AEEMRVRLAAKKQELEEILHEME---ARLEE 933 Query: 329 KGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQ 388 + G + K++ +Q L++ L + E V + ++K E+ V+ Q Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993 Query: 389 RERLQEELSQAESTIDE----LKEQVDAALGA-------EEMVEMLTDRNLNLEEKVRE- 436 +L +E E I + L E+ + A E M+ L R L EEK R+ Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR-LKKEEKSRQE 1052 Query: 437 ----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492 R+ GD +E +LQ E +++L + + E Q + + +A Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK-------KEEELQAALARLDDEIAQ 1105 Query: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEA--SVERQQQPPPETFDFKIKFAETKAHAKAIE 550 +KK R+L H+ D+ +L +++ A E+Q++ E + E + A + Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165 Query: 551 MELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKF 610 ELR A+ + +++L + + H+ + E+ +K AQ Sbjct: 1166 QELR----AKREQEVTVLKKALDEE----TRSHEAQV-----------QEMRQKHAQAVE 1206 Query: 611 ELSENCSERPGLRGAAGEQLSFA----AGLVYSLSLLQATLHRYEHALSQCSVDVYKKVG 666 EL+E + + + A L L +L EH + V + Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE--- 1263 Query: 667 SLYPEMSAHERSLDFLIELLHKDQLDETVNV-----EPLTKAIKYYQHLYSIHLAEQPED 721 L + S ER+ L + +HK Q +E +V E KAIK + + S+ Q Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQ-NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321 Query: 722 CTMQLADHIKFTQSA-LDCMSVEVGRLRAFLQGGQEA---------------TDIALLLR 765 +Q K S L + E L+ L EA +D L+ Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381 Query: 766 DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVA 825 D ++ + + K+ ++ + A A+ D L + L QE+ Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQ------QELD 1430 Query: 826 AAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPS-SSPYECLRQSCNILISTMNKLA 884 L +N+ LV+ LE+ K + + + SS Y R A Sbjct: 1431 DLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 ++ +A + +E L+AE+ D L +D + EL+KS + Sbjct: 1486 LSLARALEEALEAKEE---LERTNKMLKAEMED---LVSSKDDVGKNVHELEKSKRALET 1539 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIE-KVQTRLEETQALLRKKEKEFEETMDALQADI 1003 ++ E +L LE +L A +DA R+E +Q + + L+ ++++ EE LQ + Sbjct: 1540 QMEEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598 Query: 1004 DQLEAE-KAELKQR-LNSQSKRTIEG 1027 + E E + E KQR L + +K+ +EG Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEG 1624 Score = 75.5 bits (184), Expect = 3e-13 Identities = 123/549 (22%), Positives = 220/549 (40%), Gaps = 79/549 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLE------TLRLKRAEDKA-KL-KELEKHKIQLEQV 238 V L S + E RA++ D KL+ T L AE KA KL K++ QL+ Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA 298 QE + Q+ ++ +L++ +E + + ME + I + ++++ Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380 Query: 299 ESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR 358 + VEAL+E ++E L + EEK + +L+++ L L R Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 L S+ +++ K +L+ ++ +R+R + E + E+ L ++ AL A+E Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500 Query: 419 MVEMLTDRNLNLE------------EKVRELRETVGDLEA-MNEMNDELQENARETELEL 465 +E T++ L E + V EL ++ LE M EM +L+E E EL+ Sbjct: 1501 ELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE--LEDELQA 1557 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 E + V + + ++ A +Q +K RQL L + EL + ER+ Sbjct: 1558 TEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED------ERK 1610 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 585 Q+ A A K +E +L+ +E+ DS ++ G + Sbjct: 1611 QR------------ALAAAAKKKLEGDLKDLEL-------------QADSAIK--GREEA 1643 Query: 586 VLVLLLMPRLICKAELIRKQAQEK---FELSENCSERPGLRGAAGEQLSFAAGLVYSLSL 642 + +L + QAQ K EL + + R + A E A L L Sbjct: 1644 I------------KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691 Query: 643 LQATLHRYEHALSQCSVDVYKKVGSLYPEMSA------HERSLDFLIELLHKDQLDETVN 696 LQ L E A Q ++ + L +S +R L+ I L ++ +E N Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751 Query: 697 VEPLTKAIK 705 +E ++ ++ Sbjct: 1752 MEAMSDRVR 1760 Score = 33.5 bits (75), Expect = 1.3 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 4/82 (4%) Query: 186 AVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKM 245 A L K+ + + QV D + E + + + A++K+L++ QLE+ +E ++ Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLEEAEEESQRI 1896 Query: 246 QEQQADLQRRLKEARKEAKEAL 267 + LQR L EA E+ EA+ Sbjct: 1897 NANRRKLQRELDEA-TESNEAM 1917 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 94.7 bits (234), Expect = 5e-19 Identities = 176/853 (20%), Positives = 340/853 (39%), Gaps = 153/853 (17%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQA 250 K+ L +Q+ +L+E LE+ R R + + + + ELE K +LE + + QE ++ Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163 Query: 251 DLQRRLKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALK 309 ++ + +K +E + E ++EM + A+E E + +L++ + L+ Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223 Query: 310 ERVDELTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDAL--------VRMR 358 EL ++++L K + E K A +L+ + R++ L V + Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283 Query: 359 DLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEE 418 +++ Q K KL + + ++ +E LQEE Q S +LK+ D E Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 +E + NLE+++ L V D++ E + E A E + +L++ L+ R Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR--- 1400 Query: 479 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS--VERQQ----QPPPET 532 +E VA Y + K +L L D+ +L +Q++++ +E++Q Q E Sbjct: 1401 -------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453 Query: 533 FDFKIKFAETK--AHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLL 590 K+AE + A A+A E E + + +A+A Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARA----------------------------- 1484 Query: 591 LMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRY 650 L + KAEL R Q + E+ + S + + + E L + Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE------------------LEKS 1526 Query: 651 EHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHL 710 + AL Q ++ ++ L E+ A E D + +E +A+K Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATE---------------DAKLRLEVNLQAMKAQFER 1571 Query: 711 YSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETS 770 EQ E+ QL ++ ++ L+ + + R+ ++ ++ L +DLE Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELE----DERKQRSMAVAARKKLEMDL--KDLEAH 1625 Query: 771 CSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQ 830 + + +++ A + DC + L A +E+ A A + Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQ---------------MKDCMRELDDTRASREEILAQAKE 1670 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEG 890 L E ++ EELA A+E+ E + N + K A A++E Sbjct: 1671 NEKKLKSMEAEMIQLQEELA--AAERAKRQAQQERDELADEIAN----SSGKGALALEEK 1724 Query: 891 EYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEAN 950 +E R A L E+ + +G + DR L +AN Sbjct: 1725 R-----------RLEARIAQLEEELEEEQGNTELINDR-----------------LKKAN 1756 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDA-LQADIDQLEAE 1009 +++ + L+ A ++ E + +LE L+ K +E E T+ + +A I LEA+ Sbjct: 1757 LQIDQINTDLNLERSHA-QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815 Query: 1010 KAELKQRLNSQSK 1022 A+L+++L++++K Sbjct: 1816 IAQLEEQLDNETK 1828 Score = 88.6 bits (218), Expect = 3e-17 Identities = 201/909 (22%), Positives = 379/909 (41%), Gaps = 127/909 (13%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQ 246 V PL S++EE + A+ EE+L +R K+ + +L E+E + QL K+Q Sbjct: 834 VKPLLQVSRQEEEMMAK----EEELVKVREKQLAAENRLTEMETLQSQL-----MAEKLQ 884 Query: 247 -EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 305 ++Q + L +E + L AK++ +EE+ +A E EER + LQ E Sbjct: 885 LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA------RVEEEEERCQHLQAEK 938 Query: 306 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 355 + +++ + EL LE ++ ++ + + +LK+LEE+ L+D Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998 Query: 356 -RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAAL 414 R+ + +++ +E K + L + KN+ ++ ERL+ E Q + Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE------------- 1045 Query: 415 GAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 474 E+ L + +L +++ EL+ + +L+ +E + A E Q +MA Sbjct: 1046 -LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104 Query: 475 RVREAQKRVEAAQETV----ADYQQTIKKYRQLTAHLQDVNRELTN-------QQEASVE 523 ++RE + ++ QE + A + K+ R L L+ + EL + QQE + Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164 Query: 524 RQQQPP--PETFDFKIKFAET------KAHAKAIEMELRQMEVAQANRHMSLLTAFMPDS 575 R+Q+ +T + + K E + H++A+E Q+E Q R + L Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE--QTKRVKANLEKAKQTL 1222 Query: 576 FLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAG 635 G + V VLL K + K+ + + +L E L+ E Sbjct: 1223 ENERGELANEVKVLLQ-----GKGDSEHKRKKVEAQLQE-------LQVKFNEGERVRTE 1270 Query: 636 LVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETV 695 L ++ LQ L LSQ K L + SA E L ELL ++ + + Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSD----SKSSKLTKDFSALESQLQDTQELLQEEN-RQKL 1325 Query: 696 NVEPLTKAIKYYQHLYSIHLAEQPE----------DCTMQLADHIKFTQSALDCMSV--E 743 ++ K ++ ++ + L E+ E Q+AD K + ++ C+ E Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385 Query: 744 VGR-LRAFLQGGQEATDIALLLRD-LETSCSDIRQFCKKIRRRMPGTDAPGIPAA-LAFG 800 V R L+ L+G + + + D LE + + ++Q ++ + D A L Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ---ELDDLLVDLDHQRQSACNLEKK 1442 Query: 801 PQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGL-LVAALEE-LAFKASEQIY 858 + D LL K ++ A ++ A A A+ E + L L ALEE + KA + Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKAELERL 1498 Query: 859 GTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELRA---AALRA 913 + E L S + + ++++L + + E E ++ + EL+A A LR Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558 Query: 914 EIT----------DAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSL---LEKKL 960 E+ D +G + E+++ K+L + ++ EL + + S+ KKL Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKK---KQLVRQVREMEAELEDERKQRSMAVAARKKL 1615 Query: 961 DSAAKDADERIEKVQTRLEETQALLRKKEKEFEETM---DALQADIDQLEAEKAELKQRL 1017 + KD + I+ +E LRK + + ++ M D +A +++ A+ E +++L Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675 Query: 1018 NSQSKRTIE 1026 S I+ Sbjct: 1676 KSMEAEMIQ 1684 Score = 75.1 bits (183), Expect = 4e-13 Identities = 96/365 (26%), Positives = 170/365 (46%), Gaps = 51/365 (13%) Query: 178 TPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE- 236 T L+ A+ E E L Q R ++E L + + + ELEK K LE Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRT---EMEDLMSSKDDVGKSVHELEKSKRALEQ 1532 Query: 237 QVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 QV+E K++++E + +LQ A ++AK LE + M+ + ++ D++ E+ Sbjct: 1533 QVEEMKTQLEELEDELQ-----ATEDAKLRLEVNLQAMKAQFER----DLQGRDEQSEEK 1583 Query: 297 RAESLQQEVEALKERVDE-------------LTTDLEILKAEIE--EKGSDGAASSYQLK 341 + + ++Q E E DE L DL+ L+A I+ K D A +K Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA-----IK 1638 Query: 342 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAES 401 QL + A++KD + + D +S ++E + K EKK + +E + +LQEEL+ AE Sbjct: 1639 QLRKLQAQMKDCMRELDDTRAS-REEILAQAKENEKKLKSMEA---EMIQLQEELAAAER 1694 Query: 402 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARET 461 + +++ D A+E+ L LEEK R L + LE +EL+E T Sbjct: 1695 AKRQAQQERDEL--ADEIANSSGKGALALEEK-RRLEARIAQLE------EELEEEQGNT 1745 Query: 462 ELELREQLDMAGARVREAQKRVEA----AQETVADYQQTIKKYRQLTAHLQDVNRELTNQ 517 EL + ++L A ++ + + AQ+ QQ ++ ++L LQ++ + ++ Sbjct: 1746 EL-INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804 Query: 518 QEASV 522 +AS+ Sbjct: 1805 YKASI 1809 Score = 75.1 bits (183), Expect = 4e-13 Identities = 93/352 (26%), Positives = 171/352 (48%), Gaps = 47/352 (13%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKA-------KLKELEKH-----KIQLEQVQEWK 242 ++++ L QVR++E +LE R +R+ A LK+LE H K + E +++ + Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641 Query: 243 SKMQEQQADLQRRLKEARKEAKEAL-EAKERYMEEMADTADAIEMATLDKEM-AEERAES 300 K+Q Q D R L + R +E L +AKE E+ + +A EM L +E+ A ERA+ Sbjct: 1642 -KLQAQMKDCMRELDDTRASREEILAQAKEN--EKKLKSMEA-EMIQLQEELAAAERAK- 1696 Query: 301 LQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQ-------NARLKDA 353 +Q + E DE+ +EEK A + ++LEE+ N RLK A Sbjct: 1697 -RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755 Query: 354 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 413 +++ +++ E QK E Q+LE +Q + L+ +L + E T+ + A Sbjct: 1756 NLQIDQINTDLNLERSHAQK-NENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA 1811 Query: 414 LGAE--EMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471 L A+ ++ E L + + +++R T L+ + D+ + NA + ++Q D Sbjct: 1812 LEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE----QYKDQADK 1867 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD-------VNRELTN 516 A R+++ ++++E A+E + Q+ R+L L+D +NRE+++ Sbjct: 1868 ASTRLKQLKRQLEEAEE---EAQRANASRRKLQRELEDATETADAMNREVSS 1916 Score = 69.3 bits (168), Expect = 2e-11 Identities = 65/299 (21%), Positives = 128/299 (42%), Gaps = 40/299 (13%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 K+ L+AQ++D +L+ R R E A+ KE EK M+ + LQ Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----------KSMEAEMIQLQE 1687 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA------- 307 L A + ++A + ++ +E+A+++ +A +K E R L++E+E Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 + +R+ + ++ + ++ + S + +QLE QN LK L M S+ + Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807 Query: 368 HV--------KLQKLMEKKNQELEV----VRQQRERLQEELSQAES---TIDELKEQVDA 412 + +L++ ++ + +E + VR+ ++L++ L Q + ++ K+Q D Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867 Query: 413 ALGA--------EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 463 A EE E N + + REL + +AMN L+ R +L Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926 Score = 48.1 bits (113), Expect = 5e-05 Identities = 87/379 (22%), Positives = 142/379 (37%), Gaps = 53/379 (13%) Query: 821 LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM 880 LQE A +L A E L A +EL E+I + E + C L + Sbjct: 885 LQEQLQAETELCAEAEELRARLTAKKQEL-----EEICHDLEARVEE-EEERCQHLQAEK 938 Query: 881 NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK 940 K+ +QE E E S ++L A++ E + LED+ + + KK L+ Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998 Query: 941 IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ 1000 + ++E L+ E+K S AK ++ E + T LEE K+ +E E+T L+ Sbjct: 999 ---DRIAEFTTNLTEEEEKSKSLAKLKNKH-EAMITDLEERLRREEKQRQELEKTRRKLE 1054 Query: 1001 AD-------IDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGAIPGQAP 1053 D I +L+A+ AELK +L + + + +A + A Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEEL--------QAALARVEEEAA--------- 1097 Query: 1054 GSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLP---PLHVAKLS 1110 + L++I + IS+LQ + + ++ KA L K Sbjct: 1098 ----------QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147 Query: 1111 HEGPGSELPAGALYRKTSQ-----LLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVA 1165 E A R + L +TL + TH I +L EQ+ Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQIQEMRQKHSQAVEELAEQLE 1206 Query: 1166 QLKSLSDTVEKLKDEVLKE 1184 Q K + +EK K + E Sbjct: 1207 QTKRVKANLEKAKQTLENE 1225 Score = 42.0 bits (97), Expect = 0.004 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 24/123 (19%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQ 249 L + +KE + QVR E+KL K L +++ + EQ ++ K + Sbjct: 1823 LDNETKERQAACKQVRRTEKKL----------KDVLLQVDDERRNAEQYKDQADKASTRL 1872 Query: 250 ADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK 309 L+R+L+EA +EA+ A ++ + E+ D A E A+++ +EV +LK Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRELED--------------ATETADAMNREVSSLK 1918 Query: 310 ERV 312 ++ Sbjct: 1919 NKL 1921 >gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 94.7 bits (234), Expect = 5e-19 Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 244 +KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K + Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051 Query: 245 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 299 M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108 Query: 300 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 341 LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++ Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168 Query: 342 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 394 +++ A + RDL + Q L +K ++++ +++ +++L++ Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225 Query: 395 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 450 E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282 Query: 451 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 509 LQ + E +L E+ + R Q + +E ++ IK L LQ Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342 Query: 510 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560 + + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401 Query: 561 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 616 A H+ + A E +++ Q + E Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437 Query: 617 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 673 ER AA +Q +F L + T HA + S + +G+ L+ + Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492 Query: 674 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 729 A+E SLD L E L ++ + + LT+ I K L I + E C +Q A Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549 Query: 730 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 788 + A + E G+ LR L+ Q +++ + + + +++ +I M T Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606 Query: 789 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 848 + A + L + L AA+ + +G+L Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662 Query: 849 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 906 L A ++ E + + + N+L + + +L +++ E + + Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717 Query: 907 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 958 R L + T KLE + E +++E + + + + +++A + L+K Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777 Query: 959 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 1012 + D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827 Query: 1013 LKQRLNSQSKRTIEGLRG 1030 L+ + S+ KR E ++G Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845 Score = 89.4 bits (220), Expect = 2e-17 Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 +++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ + Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 L + +K EI++ S+ S LE+ L+D L +L S E+++ + L Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279 Query: 375 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 424 ++ ++ E ++E L +LS+ + I+ELK Q++ + A+ + Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339 Query: 425 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 472 + + L E+ E +E+ +L+ A+++ N E+ + +A + EL E Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399 Query: 473 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 532 R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ + Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458 Query: 533 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 585 ++K K ET A +A + E R + ++ A + L ++ D Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518 Query: 586 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 643 + + I + E I+KQ QEK EL E L G+ L L S + Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578 Query: 644 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 697 + + + Q + + V S+ + A RS + I L K ++++ +N Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638 Query: 698 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 747 +A++ Y++ I HL + ED QLA + + + E+ L Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694 Query: 748 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 807 RA L+ + + IA E D + + + + + +L Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729 Query: 808 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 867 ++ +K L ++ +Q ++ E A+ + A A E +S+ E Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786 Query: 868 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 924 ++++ T+ L + E E A + K +E R L E+ + + Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843 Query: 925 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 982 L E +KE L + EE + +RL L KL + K + E+ + + Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899 Query: 983 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1016 A RK + E EE + +ADI + + K +K R Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931 Score = 88.6 bits (218), Expect = 3e-17 Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%) Query: 190 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 238 L KE+ +V++L E++ ET+ E KA L +L+ + ++ + Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 293 + K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++ Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086 Query: 294 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 340 ++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146 Query: 341 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 378 ++LEE + RL++A + M RDL + Q L +K Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206 Query: 379 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 431 ++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+ Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266 Query: 432 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 491 K E + + DL A LQ + E +L E+ + R Q + +E Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323 Query: 492 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 541 ++ IK L LQ + + +QE+ E Q+ + E ++ K+ E Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382 Query: 542 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 594 T A + E+E + ++AQ A H+ + A + + R + + +++ + Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442 Query: 595 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 645 C A +++ +K E + C E L + E S L Y SL Q Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502 Query: 646 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 695 TL R L Q D+ +++ + ++ + L +E E Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562 Query: 696 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 749 + + + + +AE+ E+ +HI+ +S + E+ RL+ Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 808 ++G L ++E + + + R T GI + D L Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669 Query: 809 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 866 D ++ L V + A +L A L + E A +EL ASE++ Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 + L LI+T KL T + + + + E + E +A + ITDA + +L+ Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776 Query: 927 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 975 + L++ K + + + +RL E+ KL++ ++ + +E Q Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836 Query: 976 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 1024 R E LRK E+ +E + D +D+L+A+ K++ +++ Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895 Score = 82.0 bits (201), Expect = 3e-15 Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%) Query: 202 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 247 A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933 Query: 248 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 307 + ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+ Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+ Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050 Query: 368 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 418 + L++ K +L++ + ++++L E+L + E I L+ ++ + ALG Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 + L++K++EL+ + +LE E + A + +L +L+ R+ E Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158 Query: 479 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 534 A ++E ++ A++Q+ + + T + L + SV + Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218 Query: 535 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 589 K K + K+ K ME+ + V++A ++ + + D Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262 Query: 590 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 645 +EL K+ +++ +++ ++R L+ +GE QL LV LS QA Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313 Query: 646 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 703 + E Q ++ K +L + + D L E ++Q + L+KA Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372 Query: 704 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 759 + ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q + Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430 Query: 760 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 819 + L+ D+E + + KK R F +++ C + + A Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475 Query: 820 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 879 +E + +L + A EE S E L++ L Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514 Query: 880 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 939 ++ L + EG VE L+A + +AE LE E I ++ L Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571 Query: 940 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 999 + SE + +++ ++++D ++ +E +Q+ L + E DA+ Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618 Query: 1000 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + ++E + E++ +LN ++ E LR Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647 Score = 81.6 bits (200), Expect = 4e-15 Identities = 162/840 (19%), Positives = 343/840 (40%), Gaps = 107/840 (12%) Query: 216 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 275 LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902 Query: 276 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 321 +AD + I++ KE+ E E E + E+ A K +++ EL D++ Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962 Query: 322 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 381 L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012 Query: 382 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 440 L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+ Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071 Query: 441 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 497 + D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128 Query: 498 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 557 + R A + +L+ + E ER ++ T + K + R +E Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185 Query: 558 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 615 A Q + L DS G D + + K +L +++++ K E+ + Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237 Query: 616 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 675 S + A G L LS L++ + ++ D+ + G L E Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293 Query: 676 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 735 R LD ++ V L++ + + +Q E+ QL + IK + Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334 Query: 736 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 792 AL + LR + QE+ A L R L + +++ Q+ K TDA Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385 Query: 793 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 852 Q ++ L + +K L + +E A A L + + L +E+L Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437 Query: 853 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 912 E +C L + E + E ++ + A +L Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484 Query: 913 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 972 E+ + + D+ +K K+L+ + +L+E +L+ K ++ Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544 Query: 973 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 ++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++ Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604 Score = 66.6 bits (161), Expect = 1e-10 Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%) Query: 201 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 253 R +R +E TL ++ D +LK +L + +IQL ++ + Q Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 LK+ + +AL ++E E++A M E RA LQ E+E L+ ++ Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 + +I + E+ + +S +++ L QN L +++K+ + + Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 429 + + L+ R E+ ++ ++ A +ELK++ D + E M + + D L Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802 Query: 430 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 474 L+E + +RE G++E+ + N E + R+ E ++E Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858 Query: 475 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 527 + E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918 Query: 528 PPPETFDFKIKFAETKAHAKAIEME 552 + ++K E H K I E Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941 Score = 54.7 bits (130), Expect = 5e-07 Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 ++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+ Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719 Query: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 304 + + + K++ +++ +E + AEE+ AE L++E Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779 Query: 305 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 359 +E +K+ +++ DL++ E E+ G KQ+++ AR+++ + Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830 Query: 360 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 419 SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890 Query: 420 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 467 E ++ NL K R+L+ +LE E D + + ++ RE Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932 Score = 52.8 bits (125), Expect = 2e-06 Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 241 + +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727 Query: 242 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787 Query: 297 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 350 ++++Q V+ L+ R+DE +I K E + +G S Q + E Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847 Query: 351 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 403 K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++ Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906 Query: 404 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 434 EL+E + A AE V L ++ + KV Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937 Score = 52.0 bits (123), Expect = 4e-06 Identities = 124/604 (20%), Positives = 241/604 (39%), Gaps = 82/604 (13%) Query: 442 GDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR 501 G L + EM D+ + +L R Q G R +R+ +E + Q I+ + Sbjct: 774 GLLGLLEEMRDD-----KLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFM 828 Query: 502 QLT--AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVA 559 + ++ + + A E++ E F KIK K+ AK E+E + + + Sbjct: 829 NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ-KIKDELAKSEAKRKELEEKMVTLL 887 Query: 560 QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSER 619 + + L + + C ++ +L K + + ++A+++ E++ +E Sbjct: 888 KEKNDLQLQVQAEAEGLA--DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN---AEL 942 Query: 620 PGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSL 679 + ++ S + L L A + + +HA KV +L EM+ + ++ Sbjct: 943 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDETI 995 Query: 680 DFL------IELLHKDQLD----ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADH 729 L ++ H+ LD E V LTKA I L +Q +D L Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA--------KIKLEQQVDDLEGSLEQE 1047 Query: 730 IKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 789 K + +++ R + L+G + +++ D+E + + KK + Sbjct: 1048 KK--------LRMDLERAKRKLEGDLKLAQESIM--DIENEKQQLDEKLKKKEFEISNLQ 1097 Query: 790 APGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEEL 849 + I A G Q+ + K L + L+E A A + L LEE+ Sbjct: 1098 SK-IEDEQALGIQLQKKI----KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152 Query: 850 AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELR 907 + + E G +S+ E MNK +E E+ R + + E Sbjct: 1153 SERLEEA--GGATSAQIE------------MNK----KREAEFQKMRRDLEEATLQHEAT 1194 Query: 908 AAALRAEITDAEG-LGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKD 966 AA LR + D+ LG ++++ + V ++L+K E SE + + L +++ +K Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEK-------EKSEMKMEIDDLASNVETVSK- 1246 Query: 967 ADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1026 A +EK+ LE+ + L+ KE+E + ++ L A +L+ E E ++L+ + + Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306 Query: 1027 GLRG 1030 RG Sbjct: 1307 LSRG 1310 Score = 41.2 bits (95), Expect = 0.006 Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 242 L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++ Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867 Query: 243 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 302 ++Q+ LQ ++K +++A+EA E + + +E A EERA+ + Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920 Query: 303 QEVEALKERVDELTT 317 +V L+ + E+ T Sbjct: 1921 SQVNKLRVKSREVHT 1935 >gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo sapiens] Length = 1941 Score = 94.7 bits (234), Expect = 5e-19 Identities = 191/918 (20%), Positives = 376/918 (40%), Gaps = 152/918 (16%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ---------VQEWKSK 244 +KE++ L+ E +TL +AE+ K+ L K KI+LEQ QE K + Sbjct: 999 TKEKKALQ------EAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051 Query: 245 MQEQQADLQRRLKEARKEAKEA---LEAKERYMEEMADTADAIEMATLDKEMAEERA--E 299 M ++A +R+L+ K A+E+ +E +++ ++E + E++ L ++ +E+A Sbjct: 1052 MDLERA--KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKE-FEISNLQSKIEDEQALGI 1108 Query: 300 SLQQEVEALKERVDELTTDLE---ILKAEIEEKGSD---------------GAASSYQLK 341 LQ++++ L+ R++EL ++E +A+ E++ SD G A+S Q++ Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168 Query: 342 QLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK-------NQELEVVRQQRERLQE 394 +++ A + RDL + Q L +K ++++ +++ +++L++ Sbjct: 1169 MNKKREAEFQK---MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225 Query: 395 ELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 450 E S+ + ID+L V+ A E+M L D+ L+ K E + + DL A Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA---Q 1282 Query: 451 NDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQD- 509 LQ + E +L E+ + R Q + +E ++ IK L LQ Sbjct: 1283 RGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS 1342 Query: 510 ------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560 + + +QE+ E Q+ + E ++ K+ ET A + E+E + ++AQ Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEELEEAKKKLAQ 1401 Query: 561 ----ANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENC 616 A H+ + A E +++ Q + E Sbjct: 1402 RLQAAEEHVEAVNA------------------------KCASLEKTKQRLQNEVEDLMLD 1437 Query: 617 SERPGLRGAA--GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGS-LYPEMS 673 ER AA +Q +F L + T HA + S + +G+ L+ + Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEET-----HAELEASQKEARSLGTELFKIKN 1492 Query: 674 AHERSLDFLIELLHKDQLDETVNVEPLTKAI----KYYQHLYSIHLAEQPEDCTMQLADH 729 A+E SLD L E L ++ + + LT+ I K L I + E C +Q A Sbjct: 1493 AYEESLDQL-ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA-- 1549 Query: 730 IKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGT 788 + A + E G+ LR L+ Q +++ + + + +++ +I M T Sbjct: 1550 ---LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606 Query: 789 DAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEE 848 + A + L + L AA+ + +G+L Sbjct: 1607 ----LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662 Query: 849 L--AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVEL 906 L A ++ E + + + N+L + + +L +++ E + + Sbjct: 1663 LDDALRSQEDL-----KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1717 Query: 907 RAAALRAEITDAEGLGLKLE--------DRETVIKELKKSLKIKGEELSEANVRLSLLEK 958 R L + T KLE + E +++E + + + + +++A + L+K Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777 Query: 959 KLDSAA------KDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAE 1012 + D++A K+ ++ ++ +Q RL+E + L K K+ I +LEA E Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK----------QIQKLEARVRE 1827 Query: 1013 LKQRLNSQSKRTIEGLRG 1030 L+ + S+ KR E ++G Sbjct: 1828 LEGEVESEQKRNAEAVKG 1845 Score = 89.4 bits (220), Expect = 2e-17 Identities = 185/874 (21%), Positives = 362/874 (41%), Gaps = 106/874 (12%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 K+ + L+A++ +LEE++E R RA+ + + +L + +LE++ E +++E Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR---ELEEISE---RLEEAGGATSA 1165 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 +++ +K +EA K R E A ATL K+ A+ AE L ++++ L+ + Sbjct: 1166 QIEMNKK--REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE-LGEQIDNLQRVKQK 1222 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 L + +K EI++ S+ S LE+ L+D L +L S E+++ + L Sbjct: 1223 LEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL---SELKSKEEEQQRLINDL 1279 Query: 375 ------MEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVDAALGAEEMVEMLT 424 ++ ++ E ++E L +LS+ + I+ELK Q++ + A+ + Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339 Query: 425 DRNLN----LEEKVRELRETVGDLE-AMNEMNDELQE-------NARETELELREQLDMA 472 + + L E+ E +E+ +L+ A+++ N E+ + +A + EL E Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399 Query: 473 GARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPET 532 R++ A++ VEA A ++T ++ + L ++ E TN A+++++Q+ + Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM-LDVERTNAACAALDKKQRNFDKI 1458 Query: 533 F-DFKIKFAETKAHAKAIEMELRQM-----EVAQA-NRHMSLLTAFMPDSFLRPGGDHDC 585 ++K K ET A +A + E R + ++ A + L ++ D Sbjct: 1459 LAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1518 Query: 586 VLVLLLMPRLICKAELIRKQA-QEKFELSENCSE-RPGLRGAAGEQLSFAAGLVYSLSLL 643 + + I + E I+KQ QEK EL E L G+ L L S + Sbjct: 1519 TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578 Query: 644 QATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHK-----DQLDETVNV- 697 + + + Q + + V S+ + A RS + I L K ++++ +N Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1638 Query: 698 -EPLTKAIKYYQHLYSI------HLAE---QPEDCTMQLADHIKFTQSALDCMSVEVGRL 747 +A++ Y++ I HL + ED QLA + + + E+ L Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLA----MVERRANLLQAEIEEL 1694 Query: 748 RAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL 807 RA L+ + + IA E D + + + + + +L Sbjct: 1695 RATLEQTERSRKIA------EQELLDASERVQLLHTQ-------------------NTSL 1729 Query: 808 LDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYE 867 ++ +K L ++ +Q ++ E A+ + A A E +S+ E Sbjct: 1730 INTKKKLETDISQMQ---GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1786 Query: 868 CLRQSCNILISTMNKLATAMQEGEYDAERPPSKP-PPVELRAAALRAEITDAEGLGLK-- 924 ++++ T+ L + E E A + K +E R L E+ + + Sbjct: 1787 RMKKNME---QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843 Query: 925 --LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQ 982 L E +KE L + EE + +RL L KL + K + E+ + + Sbjct: 1844 KGLRKHERRVKE----LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899 Query: 983 ALLRKKEKEFEETMDALQADIDQLEAEKAELKQR 1016 A RK + E EE + +ADI + + K +K R Sbjct: 1900 AKFRKLQHELEEAEE--RADIAESQVNKLRVKSR 1931 Score = 88.6 bits (218), Expect = 3e-17 Identities = 192/959 (20%), Positives = 379/959 (39%), Gaps = 154/959 (16%) Query: 190 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 238 L KE+ +V++L E++ ET+ E KA L +L+ + ++ + Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026 Query: 239 QEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATLDKEM 293 + K K+++Q DL+ L++ +K + AK + ++ ++I E LD+++ Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086 Query: 294 AEERAE--SLQQEVE-------ALKERVDELTTDLEILKAEIEEKGSDGAASSYQL---- 340 ++ E +LQ ++E L++++ EL +E L+ EIE + + A + Q Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146 Query: 341 KQLEEQNARLKDA------LVRM------------RDLSSSEKQEHVKLQKLMEKK---- 378 ++LEE + RL++A + M RDL + Q L +K Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206 Query: 379 ---NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNLNLE 431 ++++ +++ +++L++E S+ + ID+L V+ A E+M L D+ L+ Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266 Query: 432 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 491 K E + + DL A LQ + E +L E+ + R Q + +E Sbjct: 1267 SKEEEQQRLINDLTAQR---GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323 Query: 492 DYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIKFAE 541 ++ IK L LQ + + +QE+ E Q+ + E ++ K+ E Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-E 1382 Query: 542 TKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLLMPR 594 T A + E+E + ++AQ A H+ + A + + R + + +++ + Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442 Query: 595 LICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLLQA- 645 C A +++ +K E + C E L + E S L Y SL Q Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502 Query: 646 TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLDETV 695 TL R L Q D+ +++ + ++ + L +E E Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562 Query: 696 NVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------RLRA 749 + + + + +AE+ E+ +HI+ +S + E+ RL+ Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL- 808 ++G L ++E + + + R T GI + D L Sbjct: 1623 KMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQ--GILKDTQI--HLDDALRS 1669 Query: 809 --DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPY 866 D ++ L V + A +L A L + E A +EL ASE++ Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV--------- 1719 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 + L LI+T KL T + + + + E + E +A + ITDA + +L+ Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKA---KKAITDAAMMAEELK 1776 Query: 927 DRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIEKVQ 975 + L++ K + + + +RL E+ KL++ ++ + +E Q Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836 Query: 976 TRLEETQALLRKKEKEFEETMDALQAD----------IDQLEAEKAELKQRLNSQSKRT 1024 R E LRK E+ +E + D +D+L+A+ K++ +++ Sbjct: 1837 KRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895 Score = 82.0 bits (201), Expect = 3e-15 Identities = 158/870 (18%), Positives = 347/870 (39%), Gaps = 138/870 (15%) Query: 202 AQVRDLEEKLETLRLKR--------------AEDKAKLKELEKHKIQLEQVQEWKSKMQE 247 A+ ++LEEK+ TL ++ A+ + + +L K KIQLE + ++ E Sbjct: 874 AKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAE 933 Query: 248 QQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEA 307 + ++ L +++ ++ ++ ++++ T +E +K E + ++L +E+ Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAG 990 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 L E + +LT + + L+ ++ D A ++ L + +L+ + + EK+ Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050 Query: 368 HVKLQKLMEKKNQELEV-------VRQQRERLQEELSQAESTIDELKEQV--DAALGAEE 418 + L++ K +L++ + ++++L E+L + E I L+ ++ + ALG Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG--- 1107 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 + L++K++EL+ + +LE E + A + +L +L+ R+ E Sbjct: 1108 ---------IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158 Query: 479 A----QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFD 534 A ++E ++ A++Q+ + + T + L + SV + Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218 Query: 535 FKIKFAETKAHAKAIEMELRQM-----EVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVL 589 K K + K+ K ME+ + V++A ++ + + D Sbjct: 1219 VKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEKMCRTLEDQL------------- 1262 Query: 590 LLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE---QLSFAAGLVYSLSL-LQA 645 +EL K+ +++ +++ ++R L+ +GE QL LV LS QA Sbjct: 1263 ---------SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA 1313 Query: 646 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKA-- 703 + E Q ++ K +L + + D L E ++Q + L+KA Sbjct: 1314 FTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372 Query: 704 -IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD 759 + ++ Y +I E+ E+ +LA ++ + ++ ++ + L Q Q + Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ--NE 1430 Query: 760 IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVA 819 + L+ D+E + + KK R F +++ C + + A Sbjct: 1431 VEDLMLDVERTNAACAALDKKQRN---------------FDKILAEWKQKCEETHAELEA 1475 Query: 820 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 879 +E + +L + A EE S E L++ L Sbjct: 1476 SQKEARSLGTELFK--------IKNAYEE-------------SLDQLETLKRENKNLQQE 1514 Query: 880 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 939 ++ L + EG VE L+A + +AE LE E I ++ L Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA---SLEHEEGKILRIQLEL 1571 Query: 940 KIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDAL 999 + SE + +++ ++++D ++ +E +Q+ L + E DA+ Sbjct: 1572 ---NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL----------DAEIRSRNDAI 1618 Query: 1000 QADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + ++E + E++ +LN ++ E LR Sbjct: 1619 RLK-KKMEGDLNEMEIQLNHANRMAAEALR 1647 Score = 81.6 bits (200), Expect = 4e-15 Identities = 162/840 (19%), Positives = 343/840 (40%), Gaps = 107/840 (12%) Query: 216 LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYME 275 LK AE + KE+ K + +++++ +K + ++ +L+ ++ KE + + E Sbjct: 846 LKSAETE---KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902 Query: 276 EMADTAD--------AIEMATLDKEMAE--ERAESLQQEVEALKERVD----ELTTDLEI 321 +AD + I++ KE+ E E E + E+ A K +++ EL D++ Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 962 Query: 322 LKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQE 381 L+ + + + A+ ++K L E+ A L + + ++ + EK + L E Q Sbjct: 963 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL----TKEK------KALQEAHQQT 1012 Query: 382 LEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR-NLNLEEKVRELRET 440 L+ ++ + +++ L++A+ +++ + ++ +L E+ + M +R LE ++ +E+ Sbjct: 1013 LDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071 Query: 441 VGDLEAMNEMNDELQENARETELE---LREQLDMAGARVREAQKRVEAAQETVADYQQTI 497 + D+E NE +L E ++ E E L+ +++ A + QK+++ Q + + ++ I Sbjct: 1072 IMDIE--NE-KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128 Query: 498 KKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQME 557 + R A + +L+ + E ER ++ T + K + R +E Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMNKKREAEFQKMRRDLE 1185 Query: 558 VA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSEN 615 A Q + L DS G D + + K +L +++++ K E+ + Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQKLEKEKSEMKMEIDDL 1237 Query: 616 CSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAH 675 S + A G L LS L++ + ++ D+ + G L E Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIN----DLTAQRGRLQTESGEF 1293 Query: 676 ERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQS 735 R LD ++ V L++ + + +Q E+ QL + IK + Sbjct: 1294 SRQLD-----------EKEALVSQLSRGKQAF--------TQQIEELKRQLEEEIKAKNA 1334 Query: 736 ---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPG 792 AL + LR + QE+ A L R L + +++ Q+ K TDA Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESK--AELQRALSKANTEVAQWRTKYE-----TDA-- 1385 Query: 793 IPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFK 852 Q ++ L + +K L + +E A A L + + L +E+L Sbjct: 1386 --------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437 Query: 853 ASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALR 912 E +C L + E + E ++ + A +L Sbjct: 1438 V-------------ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484 Query: 913 AEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIE 972 E+ + + D+ +K K+L+ + +L+E +L+ K ++ Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544 Query: 973 KVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 ++Q LEE +A L +E + + ++ +++++D+ AEK E +L R +E ++ Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604 Score = 66.6 bits (161), Expect = 1e-10 Identities = 78/385 (20%), Positives = 157/385 (40%), Gaps = 70/385 (18%) Query: 201 RAQVRDLEEKLETL--RLKRAEDKAKLK-----ELEKHKIQLEQVQEWKSKMQEQQADLQ 253 R +R +E TL ++ D +LK +L + +IQL ++ + Q Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 LK+ + +AL ++E E++A M E RA LQ E+E L+ ++ Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLA--------------MVERRANLLQAEIEELRATLE 1699 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 + +I + E+ + +S +++ L QN L +++K+ + + Sbjct: 1700 QTERSRKIAEQELLD-------ASERVQLLHTQNT----------SLINTKKKLETDISQ 1742 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAE----EMVEMLTDRNLN 429 + + L+ R E+ ++ ++ A +ELK++ D + E M + + D L Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR 1802 Query: 430 LEEKVR---------------ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGA 474 L+E + +RE G++E+ + N E + R+ E ++E Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE----LTY 1858 Query: 475 RVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVN-------RELTNQQEASVERQQQ 527 + E +K + Q+ V Q +K Y++ ++ + R+L ++ E + ER Sbjct: 1859 QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADI 1918 Query: 528 PPPETFDFKIKFAETKAHAKAIEME 552 + ++K E H K I E Sbjct: 1919 AESQVNKLRVKSRE--VHTKVISEE 1941 Score = 54.7 bits (130), Expect = 5e-07 Identities = 57/288 (19%), Positives = 132/288 (45%), Gaps = 36/288 (12%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 ++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+ Sbjct: 1664 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1719 Query: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE- 304 + + + K++ +++ +E + AEE+ AE L++E Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779 Query: 305 -----VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 359 +E +K+ +++ DL++ E E+ G KQ+++ AR+++ + Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK-----KQIQKLEARVRE----LEG 1830 Query: 360 LSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEM 419 SE++ + + K + K + ++ + Q E ++ + + + +D+L+ +V + E Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890 Query: 420 VEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 467 E ++ NL K R+L+ +LE E D + + ++ RE Sbjct: 1891 AEEQSNTNL---AKFRKLQH---ELEEAEERADIAESQVNKLRVKSRE 1932 Score = 52.8 bits (125), Expect = 2e-06 Identities = 56/271 (20%), Positives = 122/271 (45%), Gaps = 32/271 (11%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 241 + +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727 Query: 242 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787 Query: 297 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEEQNARL 350 ++++Q V+ L+ R+DE +I K E + +G S Q + E Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847 Query: 351 KDALVRMRDLS---SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE----LSQAESTI 403 K R+++L+ +++ ++LQ L++K +++ ++Q E +E+ L++ Sbjct: 1848 KHER-RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ 1906 Query: 404 DELKEQVDAALGAEEMVEMLTDRNLNLEEKV 434 EL+E + A AE V L ++ + KV Sbjct: 1907 HELEEAEERADIAESQVNKLRVKSREVHTKV 1937 Score = 52.0 bits (123), Expect = 4e-06 Identities = 124/604 (20%), Positives = 241/604 (39%), Gaps = 82/604 (13%) Query: 442 GDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR 501 G L + EM D+ + +L R Q G R +R+ +E + Q I+ + Sbjct: 774 GLLGLLEEMRDD-----KLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFM 828 Query: 502 QLT--AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVA 559 + ++ + + A E++ E F KIK K+ AK E+E + + + Sbjct: 829 NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ-KIKDELAKSEAKRKELEEKMVTLL 887 Query: 560 QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSER 619 + + L + + C ++ +L K + + ++A+++ E++ +E Sbjct: 888 KEKNDLQLQVQAEAEGLA--DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN---AEL 942 Query: 620 PGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSL 679 + ++ S + L L A + + +HA KV +L EM+ + ++ Sbjct: 943 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDETI 995 Query: 680 DFL------IELLHKDQLD----ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADH 729 L ++ H+ LD E V LTKA I L +Q +D L Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA--------KIKLEQQVDDLEGSLEQE 1047 Query: 730 IKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 789 K + +++ R + L+G + +++ D+E + + KK + Sbjct: 1048 KK--------LRMDLERAKRKLEGDLKLAQESIM--DIENEKQQLDEKLKKKEFEISNLQ 1097 Query: 790 APGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEEL 849 + I A G Q+ + K L + L+E A A + L LEE+ Sbjct: 1098 SK-IEDEQALGIQLQKKI----KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152 Query: 850 AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELR 907 + + E G +S+ E MNK +E E+ R + + E Sbjct: 1153 SERLEEA--GGATSAQIE------------MNK----KREAEFQKMRRDLEEATLQHEAT 1194 Query: 908 AAALRAEITDAEG-LGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKD 966 AA LR + D+ LG ++++ + V ++L+K E SE + + L +++ +K Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEK-------EKSEMKMEIDDLASNVETVSK- 1246 Query: 967 ADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1026 A +EK+ LE+ + L+ KE+E + ++ L A +L+ E E ++L+ + + Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306 Query: 1027 GLRG 1030 RG Sbjct: 1307 LSRG 1310 Score = 41.2 bits (95), Expect = 0.006 Identities = 35/135 (25%), Positives = 67/135 (49%), Gaps = 17/135 (12%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHK-------IQLEQVQEWK 242 L K+ + L A+VR+LE ++E+ + + AE +K L KH+ Q E+ ++ Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAE---AVKGLRKHERRVKELTYQTEEDRKNI 1867 Query: 243 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 302 ++Q+ LQ ++K +++A+EA E + + +E A EERA+ + Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA-------EERADIAE 1920 Query: 303 QEVEALKERVDELTT 317 +V L+ + E+ T Sbjct: 1921 SQVNKLRVKSREVHT 1935 >gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo sapiens] Length = 1938 Score = 94.4 bits (233), Expect = 6e-19 Identities = 178/905 (19%), Positives = 370/905 (40%), Gaps = 131/905 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLETL-----RLKRAEDKAKLKELEKHKIQLEQVQEW 241 + PL ++ E+ + D E E L R K E+K EK+ +QL+ E Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSET 899 Query: 242 KSKMQEQQA----------------DLQRRLKEARKEAKEALEAKERYMEEMADTA---- 281 ++ M ++ +L RL+E +E L AK+R +E+ + Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEE-EEEMNSELVAKKRNLEDKCSSLKRDI 958 Query: 282 DAIEMATL----DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 337 D +E+ +K E + ++L +E+ AL+E + +LT + + L+ ++ D Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018 Query: 338 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-------VRQQRE 390 ++ L + NA+L+ + EK+ L++ K +L++ + ++ Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078 Query: 391 RLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEM 450 +++E+L + E + +L+ ++D +E V +L ++K++EL+ + +LE E Sbjct: 1079 QIEEKLKKKEFELSQLQAKID-----DEQV-----HSLQFQKKIKELQARIEELEEEIEA 1128 Query: 451 NDELQENARETELELREQLDMAGARVREA----QKRVEAAQETVADYQQTIKKYRQLTAH 506 L+ + +L +L+ R+ EA ++E ++ A++Q+ + + T Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188 Query: 507 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 566 + L +Q SV + K K + K+ K ME+ ++ Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK--------MEIDDMASNIE 1240 Query: 567 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAA 626 L S + + C V + K E +Q Q +L+ + G Sbjct: 1241 AL------SKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIHDLNMQKARLQTQNGEL 1291 Query: 627 GEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELL 686 ++ L+ L+ + L + L + + K ++ + + D L E Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY 1351 Query: 687 HKDQLDETVNVEPLTKA---IKYYQHLY---SIHLAEQPEDCTMQLADHIKFTQSALD-- 738 ++Q + L+KA + ++ Y +I E+ E+ +LA ++ + + Sbjct: 1352 EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA 1411 Query: 739 ---CMSVEVGRLRAFLQGGQEATDIALLLRDLE---TSCSDI----RQFCKKI---RRRM 785 C S+E + R LQG ++ L+RDLE T+C+ + R F K + ++++ Sbjct: 1412 NSKCASLEKTKQR--LQG-----EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464 Query: 786 PGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAA 845 + A + AA +S L R VV L+ + EN+ Sbjct: 1465 DESQAE-LEAAQKESRSLSTELFKMRNAYEEVVDQLETLR----------RENKN----- 1508 Query: 846 LEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVE 905 L+E +EQI T + + ++ ++ + L A++E E E SK V+ Sbjct: 1509 LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566 Query: 906 LRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELS---EANVR----LSLLEK 958 L + +++E L K+ +++ I++LK++ + E L +A +R L+K Sbjct: 1567 LELSQVKSE------LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620 Query: 959 KLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLN 1018 K++ + + ++ ++ ETQ LR + + +++ Q +D +LK++L Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS----QLHLDDALRSNEDLKEQLA 1676 Query: 1019 SQSKR 1023 +R Sbjct: 1677 IVERR 1681 Score = 93.6 bits (231), Expect = 1e-18 Identities = 193/967 (19%), Positives = 398/967 (41%), Gaps = 165/967 (17%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLR---LKRAEDKAKLKELEKHKIQLEQVQEWK---- 242 L KE+ +V++L E++ L K ++K L+E + + QV+E K Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024 Query: 243 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-------------- 284 +K+++Q DL+ L++ +K + AK + ++ + ++I Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL 1084 Query: 285 -----EMATLDKEMAEERAESLQ--QEVEALKERVDELTTDLEI---LKAEIEEKGSDGA 334 E++ L ++ +E+ SLQ ++++ L+ R++EL ++E L+A+IE++ SD A Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144 Query: 335 ASSYQLKQLEEQNARLKDALVRM------------RDLSSSEKQEHVKLQKLMEKKNQEL 382 ++ + E+ + A + M RDL + Q L +K+ + Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV 1204 Query: 383 EVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG 442 + +Q + LQ + E ELK ++D +E L+ N+E R + + Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSELKMEID---DMASNIEALSKSKSNIERTCRTVEDQFS 1261 Query: 443 DLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR- 501 +++A +E +L + + L+ Q RV E + + ++ Q +++ + Sbjct: 1262 EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321 Query: 502 ----------------QLTAHLQDVNRE-LTNQQEASVERQQ---QPPPETFDFKIKFAE 541 Q + H D+ RE +QEA E Q+ + E ++ K+ E Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY-E 1380 Query: 542 TKAHAKAIEMELRQMEVAQANRHMSLLT-------AFMPDSFLRPGGDHDCVLVLLLMPR 594 T A + E+E + ++AQ + T A + + R G+ + ++ L Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440 Query: 595 LICKAELIRKQ-------AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATL 647 C A L +KQ A+ K +L E+ +E L A E S + L + + + Sbjct: 1441 TAC-ATLDKKQRNFDKVLAEWKQKLDESQAE---LEAAQKESRSLSTELFKMRNAYEEVV 1496 Query: 648 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSL---DFLIELLHKDQLDETVNVEPLTKAI 704 + E L + + ++ +++ L +++ ++L + +L+ +++ D V +E + ++ Sbjct: 1497 DQLE-TLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555 Query: 705 KYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGR-LRAFLQGGQEATDIALL 763 ++ E+ + +QL + +S LD +E + + Q A + Sbjct: 1556 EH----------EESKILRVQL--ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603 Query: 764 LRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQE 823 + D E R +++++M G D + L + + + +KHL V L++ Sbjct: 1604 VLDAEIRS---RNDALRLKKKMEG-DLNEMEIQLGHSNR---QMAETQKHLRTVQGQLKD 1656 Query: 824 VAAAA----------AQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC 873 + +A + GLL+ LEE+ A EQ T S E L S Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV-ALEQTERTRRLSEQELLDASD 1715 Query: 874 NI---------LISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLK 924 + LI+T KL + + + + E + E +A + ITDA + + Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKA---KKAITDAAMMAEE 1772 Query: 925 L---EDRETVIKELKKSLK-----------------IKG--EELSEANVRLSLLEKKLDS 962 L +D ++ +KK+L+ +KG +++ + R+ LE +LD Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832 Query: 963 AAKDADERIE---KVQTRLEETQALLRKKEKEF---EETMDALQADIDQLEAEKAELKQR 1016 K E ++ K + +++E + K ++ +D LQA + + + E +++ Sbjct: 1833 EQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892 Query: 1017 LNSQSKR 1023 N+Q R Sbjct: 1893 ANTQLSR 1899 Score = 56.6 bits (135), Expect = 1e-07 Identities = 69/326 (21%), Positives = 138/326 (42%), Gaps = 38/326 (11%) Query: 206 DLEEKLETLRLKRAEDKAKLKELE----KHKIQLEQVQEWKSKMQEQQADLQRRLKEA-- 259 ++ + + LRLK+ + L E+E Q+ + Q+ +Q Q D Q L +A Sbjct: 1608 EIRSRNDALRLKKKME-GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666 Query: 260 -RKEAKEALEAKER----YMEEMADTADAIEMATLDKEMAE-------ERAESLQQEVEA 307 ++ KE L ER +EE+ + A+E + ++E +R + L + + Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 L +L D+ +AE+E + + + K+ A + + L + +D S+ ++ Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786 Query: 368 HVKLQKLMEKKNQELEVVRQ--------QRERLQEELSQAESTID-ELKEQVDAALGAEE 418 L++ ++ L+ Q Q ++L+ + + E+ +D E K +A GA + Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846 Query: 419 MVEMLTDRNLNLEE---KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGAR 475 + + EE + L++ V L+A +++ R+ E E EQ + +R Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQA------KVKSYKRQAE-EAEEQANTQLSR 1899 Query: 476 VREAQKRVEAAQETVADYQQTIKKYR 501 R Q +E A E + + K R Sbjct: 1900 CRRVQHELEEAAERADIAESQVNKLR 1925 Score = 55.8 bits (133), Expect = 2e-07 Identities = 55/275 (20%), Positives = 123/275 (44%), Gaps = 44/275 (16%) Query: 204 VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEA 263 +R E+ E L + + L+ELE+ K+ LEQ + + +++ D R++ + Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724 Query: 264 KEALEAKERYMEEMADTADAIEMATLDKEMAEER-----------AESLQQE------VE 306 + K++ ++A +E + + AEE+ AE L++E +E Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784 Query: 307 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL------------ 354 +K+ +++ DL+ E E+ G Q+++LE + L++ L Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKK--QIQKLENRVRELENELDVEQKRGAEALK 1842 Query: 355 ------VRMRDLSSSEKQEH---VKLQKLMEKKNQELEVVRQQRERLQE----ELSQAES 401 ++++++ +++H ++LQ L++K +++ ++Q E +E +LS+ Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902 Query: 402 TIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRE 436 EL+E + A AE V L ++ ++ + E Sbjct: 1903 VQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937 Score = 36.6 bits (83), Expect = 0.15 Identities = 34/156 (21%), Positives = 71/156 (45%), Gaps = 49/156 (31%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLL----------EKKLDS----------- 962 +LE+ + +++ +++ ++ +EL +A+ R+ LL +KKL++ Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747 Query: 963 ---AAKDADERIEKVQT----------RLEETQALLRKKEKEFEETMDALQADIDQ---- 1005 +++A+E+ +K T + ++T A L + +K E+T+ LQ +D+ Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807 Query: 1006 -----------LEAEKAELKQRLNSQSKRTIEGLRG 1030 LE EL+ L+ + KR E L+G Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843 Score = 33.5 bits (75), Expect = 1.3 Identities = 53/268 (19%), Positives = 105/268 (39%), Gaps = 21/268 (7%) Query: 927 DRETVIKELKKSLKIKGEELSEANVRLS---LLEKKLDSAAKDADERIEKVQTRLEETQA 983 D E +++++ LK K ELS+ ++ + + K+ RIE+++ +E Sbjct: 1072 DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131 Query: 984 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGI 1043 L K EK+ + L+ ++LE ++ KR E + ATL Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191 Query: 1044 AGGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILK------GAQMKAS 1097 + + SV G +QI ++ +L+ E S LK + ++A Sbjct: 1192 TAATLRKKQADSVAELG---------EQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242 Query: 1098 LASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPS 1157 S + + E SE+ A + +QL+ LN + S + Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKD--EQQTQLIHDLNMQKARLQTQN-GELSHRVEEKE 1299 Query: 1158 AQLMEQVAQLKSLSDTVEKLKDEVLKET 1185 + + + ++L+ +E+LK ++ +ET Sbjct: 1300 SLISQLTKSKQALTQQLEELKRQMEEET 1327 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 94.0 bits (232), Expect = 8e-19 Identities = 99/400 (24%), Positives = 192/400 (48%), Gaps = 48/400 (12%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQ 248 L ++++ L +++R LEE+ +L+ ++ E++ K LEK + L+ Q+ + K K+ + Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383 Query: 249 QADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMA--TLDKEMAE-----ERAESL 301 ++ L+EA+K+ + EA + +EE A D +E L +E+ + + + Sbjct: 1384 LGTIE-SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442 Query: 302 QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR-LKDALVRMRDL 360 +E +++ D+L + + + A E+ A + + + AR L++AL + Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF 1502 Query: 361 SSSEKQEHVKLQKLMEKKN------QELEVVRQQRERLQEEL-SQAESTIDELKEQVDAA 413 KQ ++ LM K+ ELE ++ E+ EE+ +Q E DEL+ DA Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562 Query: 414 LGAEEMVEM--------LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 465 L E ++ L R+ EEK R L + V +LEA E+ DE ++ A + Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA--ELEDERKQRALAVASKK 1620 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 + ++D+ ++ + ++EAA + + IK+ R+L A ++D REL +EA R Sbjct: 1621 KMEIDL-----KDLEAQIEAANKA---RDEVIKQLRKLQAQMKDYQREL---EEARASRD 1669 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQM--EVAQANR 563 + + E++ K++E E+ Q+ E+A + R Sbjct: 1670 --------EIFAQSKESEKKLKSLEAEILQLQEELASSER 1701 Score = 93.6 bits (231), Expect = 1e-18 Identities = 177/882 (20%), Positives = 353/882 (40%), Gaps = 148/882 (16%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLK----ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 L+AQ+ +L+E E+ + R + + + + ELE K +LE + + QE + ++ Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175 Query: 256 LKEARKEAKEALEAKERYMEEMADT-ADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 + E +K +E + E +++M A A+E + E A+ +L++ + L+ E Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235 Query: 315 LTTDLEIL---KAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 371 L ++++L KAE E K A +L + RL+ L ++ KL Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA----------EKASKL 1285 Query: 372 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLE 431 Q ++ + LE ++ + ++ + ES + + +E+++ T + LNL Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD----------TQELLQEETRQKLNLS 1335 Query: 432 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV----------REAQK 481 ++R+L E L+ E +E ++N + L L+ QL +V EA+K Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395 Query: 482 RV--------EAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE--ASVERQQ----Q 527 ++ + +E Y + K +L L D+ +L +Q++ +++E++Q Q Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455 Query: 528 PPPETFDFKIKFAE--TKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDC 585 E ++AE +A A+A E E + + +A+A Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARA------------------------ 1491 Query: 586 VLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQA 645 L L K E R+ Q + ++ + S + + E L + ++ Sbjct: 1492 -----LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546 Query: 646 TLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIK 705 L E L Q + D L E++ F +L +D+ +E E IK Sbjct: 1547 QLEELEDEL-QATED-----AKLRLEVNMQAMKAQFERDLQTRDEQNE----EKKRLLIK 1596 Query: 706 YYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATD-IALLL 764 + L L ++ + + +A K M +++ L A ++ +A D + L Sbjct: 1597 QVREL-EAELEDERKQRALAVASKKK--------MEIDLKDLEAQIEAANKARDEVIKQL 1647 Query: 765 RDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEV 824 R L+ D ++ ++ R A ++ + K L+ + Sbjct: 1648 RKLQAQMKDYQRELEEAR---------------ASRDEIFAQSKESEKK-------LKSL 1685 Query: 825 AAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLA 884 A QL LA +E A +E A E T S+S L L + + +L Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEI---TNSASGKSALLDEKRRLEARIAQLE 1742 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 ++E + + E + L+ L AE+ K ++ ++ K LK K + Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802 Query: 945 EL------------SEANVRLSLLEKKLDSAAKD---ADERIEKVQTRLEETQALL---R 986 EL S ++ LE++L+ AK+ A++ + + + +L+E + R Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER 1862 Query: 987 KKEKEFEETMDALQADIDQL--EAEKAELKQRLNSQSKRTIE 1026 + +++E M+ A + QL + E+AE + + S+R ++ Sbjct: 1863 RHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904 Score = 88.6 bits (218), Expect = 3e-17 Identities = 196/969 (20%), Positives = 389/969 (40%), Gaps = 195/969 (20%) Query: 196 EEEGLRAQVRDLEEKLET-------LRLKRAEDKAKLKELEKHKIQLE------------ 236 E++ ++A ++DLEE+L+ L+L++ +AK+K++E+ + LE Sbjct: 944 EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003 Query: 237 ---QVQEWKSKMQEQQ-----------------ADLQRRLKEARKEAKEALEAKERYMEE 276 ++ E S++ E++ +DL+ RLK+ K +E +AK + E Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063 Query: 277 MADTADAIE--MATLD--KEMAEERAESLQ-----------------QEVEALKERVDEL 315 D D I A +D K ++ E LQ + V L+ ++ EL Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 D E KA + S +L+ L+ + D ++L + +QE +L+K + Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183 Query: 376 EK--KNQELEV--VRQQR----ERLQEELSQAE---STIDELKEQVDA---ALGAEEMVE 421 E+ KN E ++ +RQ+ E L E+L QA+ + +++ K+ ++ L E V+ Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE--VK 1241 Query: 422 MLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQK 481 +L E K ++L V +L A D L+ E +L+ +LD + EA+K Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301 Query: 482 R-----VEAA------QETVADYQQTIKKYRQLTAHLQDVNRE---LTNQQEASVERQQQ 527 + +AA Q+T Q+ ++ L++ ++ + E L QQE E ++ Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361 Query: 528 PPPETFDFKIKFAETKAHAKAIEMELRQME---------------VAQANRHMSLLTAFM 572 + + + A+TK K ++ +L +E ++Q +L + Sbjct: 1362 LEKQVLALQSQLADTK---KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418 Query: 573 PDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ-------AQEKFELSENCSERPGLRGA 625 + R + D + V L R + + L +KQ A+EK + ER Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVA-SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 A E+ + A L +L +E Q D+ + S Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS------------------ 1519 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLA---DHIKFTQSALDCMSV 742 KD + + NV L K+ + L +Q E+ QL D ++ T+ A + V Sbjct: 1520 --KDDVGK--NVHELEKSKRA--------LEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567 Query: 743 EVGRLRAFLQGGQEATD---------IALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGI 793 + ++A + + D + +R+LE D R+ +R + Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK-----QRAL-------- 1614 Query: 794 PAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKA 853 A+A ++ L D + EV +L A + + + L E A + Sbjct: 1615 --AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL-----EEARAS 1667 Query: 854 SEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRA 913 ++I+ S + IL +LA++ + + + + A+ A Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEIL-QLQEELASSERARRHAEQERDELADEITNSASGKSA 1726 Query: 914 EITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL----------DSA 963 + + L ++ E ++E + ++++ + + +++ L +L D+A Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786 Query: 964 AKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAE-KAELKQR--LNSQ 1020 + + + ++++ +L+E + ++ K F+ T+ AL+A I QLE + + E K+R N Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSK---FKATISALEAKIGQLEEQLEQEAKERAAANKL 1843 Query: 1021 SKRTIEGLR 1029 +RT + L+ Sbjct: 1844 VRRTEKKLK 1852 Score = 86.7 bits (213), Expect = 1e-16 Identities = 178/906 (19%), Positives = 367/906 (40%), Gaps = 135/906 (14%) Query: 187 VPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELE-KHKIQLEQVQEWKSKM 245 V PL +++EE L+A+ +E+L ++ K+ + + +L+E+E KH+ LE+ + Sbjct: 841 VKPLLQVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE-----KNI 891 Query: 246 QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEV 305 +Q + L +E + L AK++ +EE+ ++ E EER + LQ E Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES------RVEEEEERNQILQNEK 945 Query: 306 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV---------- 355 + ++ + +L L+ + ++ + + ++K++EE+ L+D Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005 Query: 356 -RMRDLSSSEKQEHVKLQKLM--------------------EKKNQELEVVRQQRE---- 390 R+ + SS +E K + L EK QELE +++ + Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065 Query: 391 RLQEELSQAESTIDELKEQV----DAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 446 LQ+++++ ++ IDELK Q+ + GA + T N + VREL+ + +L+ Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125 Query: 447 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 506 E + A + + +L E+L+ + +E +T A Q+ K Q A Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELE-------ALKTELEDTLDTTAAQQELRTKREQEVAE 1178 Query: 507 LQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMS 566 L+ E T EA ++ +Q HA A+E Q+E QA R + Sbjct: 1179 LKKALEEETKNHEAQIQDMRQ----------------RHATALEELSEQLE--QAKRFKA 1220 Query: 567 LLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRK-QAQEKFELSENCSERPGLRGA 625 L + G + D L C+ +++++ +A+ + + + ++ L Sbjct: 1221 NLEK------NKQGLETD-------NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267 Query: 626 AGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIEL 685 E L S LQ L L + KK + ++ E L EL Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAE----KKGIKFAKDAASLESQLQDTQEL 1323 Query: 686 LHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG 745 L +++ + +N+ + ++ ++ E+ E+ L + QS L +V Sbjct: 1324 L-QEETRQKLNLSSRIRQLEEEKNSLQ-EQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381 Query: 746 RLRAFLQGGQEATDIALLLRDLETSCSDIRQFC------KKIRRRMPGTDAPGIPAALAF 799 ++ +EA LL+D E + + +K + R+ + + L Sbjct: 1382 DDLGTIESLEEAK--KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ-QELDDLTVDLDH 1438 Query: 800 GPQVSDTLLDCRKHLTWVVAVLQEVAAA------AAQLIAPLAENEGLLVAALEELAFKA 853 QV+ L +K ++A + ++A A+ A E + L +A E A +A Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498 Query: 854 SEQIYGTPSSSPYEC----------------LRQSCNILISTMNKLATAMQEGEYDAERP 897 E+ + L +S L + ++ T ++E E + + Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558 Query: 898 PSKPPPVELRAAALRAEI-TDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLL 956 +E+ A++A+ D + + E+++ ++ + + L+ + E+ + Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618 Query: 957 EKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLEAEKAEL 1013 +KK++ KD + +IE +E LRK + K+++ ++ +A D++ A+ E Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678 Query: 1014 KQRLNS 1019 +++L S Sbjct: 1679 EKKLKS 1684 Score = 78.2 bits (191), Expect = 5e-14 Identities = 85/345 (24%), Positives = 152/345 (44%), Gaps = 26/345 (7%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 K+ L+AQ++D + +LE R R E A+ KE EK +L+ ++ ++QE+ A +R Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK---KLKSLEAEILQLQEELASSER 1701 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA--EERAESLQQEVEALKERV 312 + A +E E A E +A E L+ +A EE E Q +E L +R Sbjct: 1702 ARRHAEQERDEL--ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759 Query: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK-L 371 + T ++ L AE+ + S S +QLE QN LK L + S+ + + L Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819 Query: 372 QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQV-DAALGAEEMVEMLTDRNLNL 430 + + + ++LE ++R + + + E + E+ QV D A++ E + N + Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879 Query: 431 EEKVRELRETVGDLEAMNEMNDELQ---ENARETELELREQLDMAGARVREAQKRVEAAQ 487 ++ R+L E + N +LQ ++A E L ++ R+R Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------ 1933 Query: 488 ETVADYQQTIKKYRQLTAHLQDVNRELTN---QQEASVERQQQPP 529 + + RQL HL+ + EL++ + + S + QPP Sbjct: 1934 ---ISFSSSRSGRRQL--HLEGASLELSDDDTESKTSDVNETQPP 1973 Score = 77.0 bits (188), Expect = 1e-13 Identities = 99/442 (22%), Positives = 191/442 (43%), Gaps = 87/442 (19%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLE-QVQEWKSKMQEQQADLQ 253 K L R LE+++E +R + E + +L+ E K++LE +Q K++ + DLQ Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DLQ 1581 Query: 254 RRLKEARKEAKEALEAKERYME-EMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 312 R E +E K L + R +E E+ D +A K+ E + L+ ++EA + Sbjct: 1582 TR-DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640 Query: 313 DELTTDLEILKAEI--------------EEKGSDGAASSYQLKQLEEQNARLKDALVRMR 358 DE+ L L+A++ +E + S +LK LE + +L++ L Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700 Query: 359 DLSSSEKQEHVKL-----------QKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 407 +QE +L L+++K + + Q E L+EE S E D + Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760 Query: 408 E---QVD---AALGAEEMVEMLTD--------RNLNLEEKVREL--------RETVGDLE 445 + QVD A L AE +D +N L+ K++EL + T+ LE Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820 Query: 446 A-MNEMNDELQENARE----------TELEL-----------------REQLDMAGARVR 477 A + ++ ++L++ A+E TE +L +EQ++ A AR++ Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880 Query: 478 EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKI 537 + ++++E A+E + +K ++ + N L+ + R ++ P I Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP------I 1934 Query: 538 KFAETKAHAKAIEMELRQMEVA 559 F+ +++ + + +E +E++ Sbjct: 1935 SFSSSRSGRRQLHLEGASLELS 1956 Score = 46.6 bits (109), Expect = 1e-04 Identities = 53/217 (24%), Positives = 92/217 (42%), Gaps = 22/217 (10%) Query: 820 VLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILIST 879 +L E A +L A E L A +EL E ++ S E R IL + Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQEL----EEILHDLESRVEEEEERNQ--ILQNE 944 Query: 880 MNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSL 939 K+ +Q+ E + ++L A+I E L LED+ + + K Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS---KFIKEK 1001 Query: 940 KIKGEELSEANVRLSLLEKKLDSAAK----------DADERIEKVQTRLEETQALLRKKE 989 K+ + ++E + +L+ E+K + AK D +ER++K + +E + RK + Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061 Query: 990 KEFEETMDA---LQADIDQLEAEKAELKQRLNSQSKR 1023 E + D LQA ID+L+ + A+ ++ L R Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 93.6 bits (231), Expect = 1e-18 Identities = 184/884 (20%), Positives = 340/884 (38%), Gaps = 109/884 (12%) Query: 191 PSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQA 250 PS E L + + E L ++ E + KEL+ K L+Q ++ + ++ Q Sbjct: 387 PSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVM 446 Query: 251 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK- 309 +LQ +LK + AKE ++++ +T + +E K+ EE+ ++E+ ALK Sbjct: 447 ELQNKLKHVQGPEP----AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKG 502 Query: 310 ---ERVDELTTDLEILKAEIEE------KGSDGAASSYQLKQLEEQNARLKDALVRMRDL 360 E V ++E ++ + + + A + + + E Q ALVR Sbjct: 503 ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKM---SALVRGLQR 559 Query: 361 SSSEKQEHVKLQKLMEKKN--------QELEVVRQQRERLQEELSQAESTIDELKEQVDA 412 E E + M +KN QEL +R ++E ++EEL + + EQ A Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619 Query: 413 ALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELR-EQLDM 471 + G VE+L L +E+++EL+ + E+ R+ ELE + L + Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQ--------AERQSQEVAGRHRDRELEKQLAVLRV 671 Query: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 531 R RE +++ Q+T+ +Q ++ + + + + Q+ A+VE + E Sbjct: 672 EADRGRELEEQNLQLQKTLQQLRQDCEEASK-AKMVAEAEATVLGQRRAAVETTLRETQE 730 Query: 532 TFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLL 591 D E + +E +L++ L GG+ + Sbjct: 731 END------EFRRRILGLEQQLKETR------------------GLVDGGE-------AV 759 Query: 592 MPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGE----QLSFAAGLVYSLSLLQATL 647 RL K + + + Q+ E E G AA +L A + L Q TL Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819 Query: 648 HRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYY 707 +R + + + L + +R++D L + L K D ++ L ++ Y Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879 Query: 708 QHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDL 767 + +A+ A + T L + E+ RLR LQ Q D A L ++L Sbjct: 880 KEKARREVADAQRQ-AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938 Query: 768 ETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAA 827 + +R+ G + + D K L V+ L+ Sbjct: 939 -------------LAQRLQGLEQEA-----ENKKRSQDDRARQLKGLEEKVSRLETELDE 980 Query: 828 AAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSC---NILISTMNKLA 884 + L + +++L +E + + EC + S N + T + Sbjct: 981 EKNTVELLTDRVNRGRDQVDQL---RTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037 Query: 885 TAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGE 944 Q+ + S+ ++ R A E T + KLE + +KEL ++ + + Sbjct: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK---VKELSIQIEDERQ 1094 Query: 945 ELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADID 1004 +++ +LSL K L +A+E IE RL+ + +++ +E E + LQA I Sbjct: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIE----RLDGLRKKAQREVEEQHEVNEQLQARIK 1150 Query: 1005 QLEAEKAELKQRLNSQSKRTIEGLRGP-------PPSGIATLVS 1041 LE + R ++S EGL PS IA+L++ Sbjct: 1151 SLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLT 1194 Score = 84.3 bits (207), Expect = 6e-16 Identities = 89/346 (25%), Positives = 159/346 (45%), Gaps = 44/346 (12%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK----HKIQLEQVQ----EW 241 L K+ E LR +LEE+ L R D+ KELEK K L+Q+Q ++ Sbjct: 823 LEEEGKQREVLRRGKAELEEQKRLL--DRTVDRLN-KELEKIGEDSKQALQQLQAQLEDY 879 Query: 242 KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM-------ATLDKEMA 294 K K + + AD QR+ K+ EA++ R +E+ A++ A LDKE+ Sbjct: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939 Query: 295 EERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDAL 354 +R + L+QE E K D+ L+ L+ ++ ++ ++ L ++ R +D + Sbjct: 940 AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQV 999 Query: 355 VRMRDLSSSEK--QEHVKLQKL-MEKKNQELEVVRQQRERLQE---ELSQAESTIDELKE 408 ++R E+ ++ ++ K+ +E++N++L+ E Q+ LSQ ES L+E Sbjct: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE 1059 Query: 409 QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQ 468 ++ A E +L N LE KV+EL ++ DE Q + +Q Sbjct: 1060 RLQAE---EREKTVLQSTNRKLERKVKELSI---------QIEDERQH--------VNDQ 1099 Query: 469 LDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNREL 514 D RV+ +++V+ A+E + KK ++ +VN +L Sbjct: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145 Score = 63.5 bits (153), Expect = 1e-09 Identities = 85/386 (22%), Positives = 169/386 (43%), Gaps = 65/386 (16%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLR-------LKRAEDKAKLKELEKHKIQLEQVQEWK 242 L +E + R ++ LE++L+ R A + KL+ LE K QLE+ Sbjct: 725 LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN-A 783 Query: 243 SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQ 302 S+ +E +R EAR E EA R +E A+E +E+ L+ Sbjct: 784 SQEEEGSLAAAKRALEARLE--EAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841 Query: 303 QEVEALKERVDELTTDLE-----------ILKAEIEEK------------------GSDG 333 ++ L VD L +LE L+A++E+ S+ Sbjct: 842 EQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEA 901 Query: 334 AASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK-LMEKKNQELEVVRQQRERL 392 +S L +L+++ RL+ AL +S +++ +L K L+ ++ Q LE + ++R Sbjct: 902 EKTSGGLSRLQDEIQRLRQAL-----QASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956 Query: 393 QEELSQAESTIDELKEQVDAALGAEE-MVEMLTDRNLNLEEKVRELRETV-------GDL 444 Q++ ++ ++E +++ L E+ VE+LTDR ++V +LR + DL Sbjct: 957 QDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL 1016 Query: 445 EAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETV--ADYQQTI----- 497 E ++++ E Q +T L E A + + + + + QE + + ++T+ Sbjct: 1017 EC-DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTN 1075 Query: 498 ----KKYRQLTAHLQDVNRELTNQQE 519 +K ++L+ ++D + + +Q++ Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKD 1101 >gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 724 Score = 91.7 bits (226), Expect = 4e-18 Identities = 84/374 (22%), Positives = 180/374 (48%), Gaps = 16/374 (4%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKI--QLEQVQEWKSKMQEQQADLQ 253 E + L +++ + KL+ +++ E +L + ++ K+ Q E++QEW+ K+QEQ+ + Sbjct: 327 EADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI- 384 Query: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313 R +E +E +E + +E M E + E +KE R E + E E ++ Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 E + E ++ E EEK + Q K+ +EQ A++ ++R+ +++ K+ + Sbjct: 445 EKMHEQEKIR-EQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQEEKMWR 502 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKE---QVDAALGAEEMVEMLTDRNLNL 430 EK +++ ++ +++ + QEE+ + E I E +E Q + EE + ++ Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562 Query: 431 EEKVRELRETVGDLE----AMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 486 EEK+ + E + + E E E +E RE E ++REQ +M + + ++ E Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622 Query: 487 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ---QQPPPETFDFKIKFAETK 543 E Q+ +K R+ +++ +++ Q+E E++ Q+ + ++ + K E + Sbjct: 623 CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682 Query: 544 AHAKAIEMELRQME 557 + E ++R+ E Sbjct: 683 EKMQEQEEKMRRQE 696 Score = 89.0 bits (219), Expect = 3e-17 Identities = 70/367 (19%), Positives = 170/367 (46%), Gaps = 19/367 (5%) Query: 203 QVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKE 262 ++++ EEK++ K E + K++E E+ + E++ K + +Q ++ +E + Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428 Query: 263 AKEALEAKERYMEEMADTADAIEMATLDKEMAEE----RAESLQQEVEALKERVDELTTD 318 +E + KE + E+ + E +E +E R + +QE EA R +E + Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488 Query: 319 LEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK 378 E E EEK ++ +++ E+ R ++ R +QE + QK EK Sbjct: 489 QEEKIREQEEKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIREQEEIWRQK--EKI 545 Query: 379 NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELR 438 +++ E +R+Q E++ + + ++++EQ + EE + EEK+RE Sbjct: 546 HEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR-------EQEEKIREQE 598 Query: 439 ETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIK 498 E + + E M + +E E E E++ ++R ++++ ++ + + ++ I+ Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658 Query: 499 KYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEV 558 + ++ +Q+ ++ Q+E E++++ + + K++ E K + + + ++ ++ Sbjct: 659 EQEEM---MQEQEEKMWEQEEKMCEQEEKMQEQ--EEKMRRQEEKMWEQEVRLRQQEEKM 713 Query: 559 AQANRHM 565 + H+ Sbjct: 714 QEHQEHL 720 Score = 83.2 bits (204), Expect = 1e-15 Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 46/381 (12%) Query: 182 TSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW 241 TS G P + A R+LE ++ T+R+ + K +L+ + L Q Sbjct: 161 TSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQ-KTELQ------MALYYSQHA 213 Query: 242 KSKMQEQQADLQRRLKEARK---EAKEALEA-------KERYMEEMADTADAIEMA---- 287 +++ + DL RL ++ K E ++AL A +RY+EE+ DA+ + Sbjct: 214 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273 Query: 288 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILK----------------AEIEEKGS 331 T+ E +E+ LQ++++ ++ E+ +++ LK AE + G Sbjct: 274 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 333 Query: 332 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHV-----KLQKLMEKKNQELEVVR 386 + + S +L+ E+N L + L + ++ ++E + K+Q+ EK ++ E +R Sbjct: 334 ELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392 Query: 387 QQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEA 446 +Q E+++ + ++++ Q + EE + + EEK+REL E + + E Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452 Query: 447 MNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH 506 + E ++ QE + E E R++ + A++ ++++ +E + + ++ + + + Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509 Query: 507 LQDVNRELTNQQEASVERQQQ 527 + + E Q++ + RQ++ Sbjct: 510 QEKIREEEKRQEQEEMWRQEE 530 Score = 82.8 bits (203), Expect = 2e-15 Identities = 76/322 (23%), Positives = 163/322 (50%), Gaps = 29/322 (9%) Query: 195 KEEEGLRAQVRDLEEKLETLRL--KRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 252 ++EE +R Q + EK E +R ++ ++ K++E E+ + + E+++E + K QEQ+A + Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKM 479 Query: 253 QRRLKEARKEAKEALEAKERY--MEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 310 R+ ++ R++ ++ E +E+ EE + I ++E +E+ E +QE E ++E Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQE-EKIRE 534 Query: 311 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 370 + +E+ E + E EEK +++ EE+ R ++ +M D +++ K Sbjct: 535 Q-EEIWRQKEKIH-EQEEK----------IRKQEEKMWRQEE---KMHDQEEKIREQEEK 579 Query: 371 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 430 + + EK ++ E +R+Q E+++E+ + +++ EQ + EE ++ ++ Sbjct: 580 VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639 Query: 431 EEKVRE----LRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 486 EEK+RE +RE + EM E +E E E ++ EQ + + + +++ E Sbjct: 640 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 699 Query: 487 QETVADYQQTIKKYRQLTAHLQ 508 E +Q +K ++ HL+ Sbjct: 700 WEQEVRLRQQEEKMQEHQEHLE 721 Score = 79.0 bits (193), Expect = 3e-14 Identities = 68/299 (22%), Positives = 150/299 (50%), Gaps = 29/299 (9%) Query: 203 QVRDLEEKL-ETLRLKRAEDKA----KLKELEKHKIQL-------EQVQEWKSKMQEQQA 250 ++R+LEEK+ E +++ E+K K++E EK + Q E+++E + K++EQ+ Sbjct: 439 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 498 Query: 251 DLQRRLKEARKEAKEALEAKERYMEEMADTADAI---EMATLDKEMAEERAESLQQEVEA 307 + R+ ++ ++ K E K + EEM + I E KE E+ E ++++ E Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558 Query: 308 LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQE 367 + + +++ E ++ + E+ Q +++ EQ ++++ ++ ++ Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ 618 Query: 368 HVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 K+ + EK ++ E +R+Q E+++E+ + ++++EQ EEM++ ++ Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-------EEMMQEQEEKM 671 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 486 EEK+ E E + + E E +E E E+ LR+Q + +++E Q+ +EAA Sbjct: 672 WEQEEKMCEQEEKMQEQE---EKMRRQEEKMWEQEVRLRQQEE----KMQEHQEHLEAA 723 Score = 75.1 bits (183), Expect = 4e-13 Identities = 75/340 (22%), Positives = 158/340 (46%), Gaps = 22/340 (6%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRA---EDKAKLKELEKHKIQLEQ-VQEWKSKMQEQQA 250 ++EE +R Q + EK E +R + E + K++ E+ + E+ ++E + KM EQ+ Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE- 451 Query: 251 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 310 + R +E +++ +E + +E+ E+ A E +E E+ E + ++ E + E Sbjct: 452 --KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509 Query: 311 ----RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366 R +E + E + + EEK + Q +++ EQ +++ +M Sbjct: 510 QEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568 Query: 367 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDR 426 + K+++ EK ++ E +R+Q E+++E+ ++++EQ + EE + ++ Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQ-------EEKIREQEEMTQEQEEKMGEQEEK 621 Query: 427 NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAA 486 EEK++E E + E E ++ RE E ++REQ +M + + ++ E Sbjct: 622 MCEQEEKMQEQEE---KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678 Query: 487 QETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 E Q+ +K R+ + + L Q+E E Q+ Sbjct: 679 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718 Score = 68.2 bits (165), Expect = 5e-11 Identities = 48/225 (21%), Positives = 115/225 (51%), Gaps = 7/225 (3%) Query: 195 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 252 ++EE + Q +R+ E++ E + R E+K ++E E+ Q E++ E + K+++Q+ + Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEK--IREQEEIWRQKEKIHEQEEKIRKQEEKM 559 Query: 253 QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 312 R+ ++ + ++ E +E+ + + E +E E+ E Q++ E + E+ Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619 Query: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 372 +++ E ++ + E+ Q K++ EQ ++++ M++ ++ K+ Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 679 Query: 373 KLMEKKNQELEVVRQQRERLQEE---LSQAESTIDELKEQVDAAL 414 + EK ++ E +R+Q E++ E+ L Q E + E +E ++AA+ Sbjct: 680 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724 Score = 64.3 bits (155), Expect = 7e-10 Identities = 58/275 (21%), Positives = 132/275 (48%), Gaps = 25/275 (9%) Query: 196 EEEGLRAQV--RDLEEKLETLRLKRAEDKAKL-KELEKHKIQLEQVQEWKSKM--QEQQA 250 E+E +R Q R EEK+ KR E +AK+ ++ EK + Q E+++E + KM QE++ Sbjct: 449 EQEKIREQEEKRQEEEKIREQE-KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507 Query: 251 DLQRRLKEARK---------------EAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 Q +++E K E +E KE+ E+ E +E Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 ++ E ++++ E + + +++ E ++ + E+ + Q +++ EQ ++ + Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALG 415 +M++ +++ K+++ +K ++ E +R+Q E +QE+ + +++ EQ + Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 687 Query: 416 AEEMV----EMLTDRNLNLEEKVRELRETVGDLEA 446 EE + E + ++ + L ++ +++E LEA Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722 Score = 48.1 bits (113), Expect = 5e-05 Identities = 56/311 (18%), Positives = 136/311 (43%), Gaps = 27/311 (8%) Query: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMA----EERAESLQQEVEALKERV 312 ++ +K + + EA R +E T + + +MA + + L+ E L R+ Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 228 Query: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQ 372 + L+ + + + +++L ++ L L R K+++ KLQ Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 288 Query: 373 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDA-ALGAEEMVEMLTDRNLNLE 431 + ++ E ++ + L+ +L +A+ + + + Q +A LG E L+ Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE------------LQ 336 Query: 432 EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 491 +L+ V + E N +N + +E E +++E + +++E ++++ +E + Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEEKIR 392 Query: 492 DYQQTIKKYRQLTAHLQDVNR---ELTNQQEASVERQQQPPPETFDFKIKFAETKAH--A 546 + ++ +++ ++ ++ R E+ ++E + RQ++ E + KI+ E K H Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQE 451 Query: 547 KAIEMELRQME 557 K E E ++ E Sbjct: 452 KIREQEEKRQE 462 Score = 35.4 bits (80), Expect = 0.34 Identities = 17/106 (16%), Positives = 58/106 (54%), Gaps = 6/106 (5%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 980 K+ ++E I+E ++ ++ + E E ++ E+K+ + ++ +E++ + + ++ E Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645 Query: 981 TQALLRKKEKEFEETMDALQADIDQL---EAEKAELKQRLNSQSKR 1023 + +R++E++ E + +Q +++ E + E ++++ Q ++ Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691 Score = 34.7 bits (78), Expect = 0.59 Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 7/102 (6%) Query: 926 EDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALL 985 ++R+ + EL ++ I EEL E N +L + ++S + +++++ +LE + LL Sbjct: 261 KERDALSLELYRNT-ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319 Query: 986 RKKEKEFE-----ETMDALQADIDQLEAEKAELKQRLNSQSK 1022 +++ + E + + ++ A + Q + E+ EL RLN Q + Sbjct: 320 PQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNRLNQQQE 360 Score = 34.7 bits (78), Expect = 0.59 Identities = 17/83 (20%), Positives = 49/83 (59%), Gaps = 3/83 (3%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 980 K+ ++E I+E ++ ++ + E + E ++ E+K+ + ++ +E++ + + ++ E Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701 Query: 981 TQALLRKKEKEFEETMDALQADI 1003 + LR++E++ +E + L+A I Sbjct: 702 QEVRLRQQEEKMQEHQEHLEAAI 724 Score = 33.1 bits (74), Expect = 1.7 Identities = 23/99 (23%), Positives = 50/99 (50%), Gaps = 1/99 (1%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 983 K+ D+E I+E ++ + + E++ E ++ E+K+ + E+ EK+ + EE Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ-EEKMC 623 Query: 984 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSK 1022 +K +E EE M + I + E + E ++++ Q + Sbjct: 624 EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662 Score = 31.2 bits (69), Expect = 6.5 Identities = 18/109 (16%), Positives = 58/109 (53%), Gaps = 6/109 (5%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKL---DSAAKDADERIEKVQTRLEE 980 K+ ++E I++ ++ + + E++ + ++ E+K+ + ++ +E+I + + ++ E Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603 Query: 981 TQALLRKKEK---EFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1026 + + +++E+ E EE M + + + E + ++++ Q K+ E Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 91.3 bits (225), Expect = 5e-18 Identities = 73/352 (20%), Positives = 180/352 (51%), Gaps = 28/352 (7%) Query: 195 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 251 ++EE LR Q +R+ EEK+ + E + +L+E EK + ++++E + +MQEQ+ Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356 Query: 252 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 311 + + ++ R++ ++ +ER E+ + + +E E+ E L+++ E ++E+ Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416 Query: 312 VDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL 371 +++ +E ++ E + + + + K EE+ R ++ +R + + E++E ++ Sbjct: 417 -EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475 Query: 372 QK----LMEKKNQELEVVRQQRERL--QEELSQAESTIDELKEQV---------DAALGA 416 Q+ E+K + + + +Q+E+L QE++ + E I E +E++ + + Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDL-EAMNEMNDELQENARETELELREQLDMAGAR 475 +E + D+ EEK+R+ + + D E M + E ++ + E ++RE+ R Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-----ER 590 Query: 476 VREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQ 527 +RE +K++ +E + + ++ K ++ +Q+ ++ Q+E E++++ Sbjct: 591 MREREKKMREEEEMMREQEE---KMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639 Score = 88.2 bits (217), Expect = 4e-17 Identities = 88/392 (22%), Positives = 184/392 (46%), Gaps = 47/392 (11%) Query: 190 LPSPSKEEEGLRAQVRDLEEKLETLRL--------------------KRAEDKAKLKELE 229 LP E+ ++ V++L+ KLE + R ++K K+ E Sbjct: 234 LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293 Query: 230 KHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATL 289 K Q E+++E + KM+EQ+ + R+ K R++ KE L +E+ + E + + E Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELREQKELREQEEQMQE 352 Query: 290 DKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNAR 349 +E E+ E ++++ E + R +E + E E E+K D Q +++ EQ+ R Sbjct: 353 QEEKMWEQEEKMREQEEKM-WRQEERLWEQEKQMREQEQKMRD------QEERMWEQDER 405 Query: 350 LKDALVRMRDLSSS----EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDE 405 L++ RMR+ EK K + EKK ++ E Q+ ER++E + + Sbjct: 406 LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET 465 Query: 406 LKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELEL 465 ++EQ + EE + ++ ++++ E +E + + E M E +++ E E ++ Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEKMQEQEEKIWEQ----EEKI 520 Query: 466 REQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQ 525 R+Q +M G Q++ QE + + + + + + ++D +++ +Q+E ++ Sbjct: 521 RDQEEMWG------QEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKMWDQEERMEKKT 571 Query: 526 QQPPPETFDFKIKFAETKAHAKAIEMELRQME 557 Q+ +T+D + K E + + E ++R+ E Sbjct: 572 QEQEKKTWDQEEKMRE-EERMREREKKMREEE 602 Score = 85.1 bits (209), Expect = 4e-16 Identities = 86/402 (21%), Positives = 184/402 (45%), Gaps = 35/402 (8%) Query: 195 KEEEGLRAQ--VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 252 ++E+ LR Q +R+ EE+++ K E + K++E E+ K+ ++ + W+ + Q ++ + Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQ 390 Query: 253 QRRLKEARK-EAKEALEAKERYMEEMADTADAIEMATLDKEMAEERA-----ESLQQEVE 306 + R +E R E E L KE M E + +E +K+M E+ E QE E Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450 Query: 307 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366 ++ER ++ + E ++ E EEK + ++ ++ E Q RL + ++ + ++Q Sbjct: 451 RIREREKKMREEEETMR-EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509 Query: 367 EHV------KLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 E K++ E QE ++ RQ++ R QE+ Q +++++Q EE + Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED--QMWEQEEKMRDQEQKMWDQEERM 567 Query: 421 EMLT-----------------DRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL 463 E T +R E+K+RE E + + E + +E + E Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627 Query: 464 ELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVE 523 E E++ ++ E ++++ +E + + Q+ ++ +L H + +E +QE + Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687 Query: 524 RQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHM 565 Q++ +T + + K + + + M R+ ++ + M Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729 Score = 81.6 bits (200), Expect = 4e-15 Identities = 75/388 (19%), Positives = 179/388 (46%), Gaps = 25/388 (6%) Query: 195 KEEEGLRAQ---VRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 251 +EE+ ++ Q RD EEK++ R +K +E E + Q E++Q+ + M EQ+ Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486 Query: 252 --LQRRLKEARK---EAKEALEAKERYMEEMADTADAIEMATLDKEM-AEERAESLQQEV 305 Q+RL E ++ E ++ E +E+ E+ D EM +K+M +E+ + ++ Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546 Query: 306 EALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEK 365 +E++ + + + +E+K + ++ ++ + R+++ +MR+ + Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606 Query: 366 QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE---- 421 ++ K+Q+ EK ++ E + +Q E++QE+ + +++ EQ + + + E Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666 Query: 422 MLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ------------ENARETELELREQL 469 + + +EK++E E + + E M + E + E+ RE E ++RE+ Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726 Query: 470 DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 529 +M + + Q++ E QE + + +K + + + R +++ + Q Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786 Query: 530 PETFDFKIKFAETKAHAKAIEMELRQME 557 + ++ + K + + + E ++R E Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQE 814 Score = 79.3 bits (194), Expect = 2e-14 Identities = 68/320 (21%), Positives = 155/320 (48%), Gaps = 20/320 (6%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAE--DKAKLKELEKHKIQLEQVQEWKSKMQEQQA--- 250 E+E ++ Q + E+ E +R + + K+ EK + Q +Q+ E + KM++Q+ Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561 Query: 251 DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 310 D + R+++ +E ++ +E M E + + ++EM E+ E +Q++ E ++E Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621 Query: 311 RVDELTTDLEILKA------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 364 + +++ E ++ E EEK + ++ ++L EQ +L + E Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681 Query: 365 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE------STIDELKEQVDAALGAEE 418 ++E + Q+ MEKK QE E +E+++EE S E + ++EQ + EE Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741 Query: 419 MVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVRE 478 ++ + EEK+ E E + + + + E ++L E+ + E +E++ ++R+ Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE---QEKIWEQEEKMRD 798 Query: 479 AQKRVEAAQETVADYQQTIK 498 ++++ +E + ++ ++ Sbjct: 799 QEEKMRGQEEKMRGQEEKMR 818 Score = 75.9 bits (185), Expect = 2e-13 Identities = 76/337 (22%), Positives = 154/337 (45%), Gaps = 36/337 (10%) Query: 206 DLEEKLETLRLKRAEDKAKLKELEKHK----IQLEQVQEWKSKMQEQQADLQRRLKEARK 261 +L+ L + + + ++EL K + ++L + +++++ A+LQ +L A Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239 Query: 262 EAKEA-LEAKE--RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE-----RVD 313 E E L KE R +E ++ TL +EM + E +QE + K+ R + Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299 Query: 314 ELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQK 373 E + E E EEK Q K+L EQ L++ +R+ +QE ++Q+ Sbjct: 300 ERLREQEGKMREQEEK------MWRQEKRLREQEKELREQEKELREQKELREQEE-QMQE 352 Query: 374 LMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEK 433 EK ++ E +R+Q E++ + + +++EQ EE + +R EE+ Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412 Query: 434 VRELRETVGDLEAMNEMN--DELQENARETELELREQLDMAGARVREAQKRVEAAQETVA 491 +RE + +E M E E ++ R+ E +++E+ R+RE +K++ +ET+ Sbjct: 413 MREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-----ERIREREKKMREEEETMR 467 Query: 492 DYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQP 528 + ++ ++K + + Q+E ++Q+ P Sbjct: 468 EQEEKMQKQEE----------NMWEQEEKEWQQQRLP 494 Score = 64.7 bits (156), Expect = 5e-10 Identities = 64/281 (22%), Positives = 139/281 (49%), Gaps = 28/281 (9%) Query: 195 KEEEGLRAQVRDLEEKLETL--RLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADL 252 ++EE ++ Q + E+ E + + ++ ++ +L E ++ + E++QE + KMQEQ+ + Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE-QEKMQEQEEKI 686 Query: 253 --QRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKE 310 Q ++++ +E ++ +E+ EE + +M ++EM E+ E +Q++ E ++E Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE-EEEMMREQEEKMQEQEEKMQE 745 Query: 311 RVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVK 370 + +E+ E EEK + ++ ++L EQ +L + + QE K Sbjct: 746 QEEEMW--------EQEEKMWEQEEKMWEQQRLPEQKEKLWE---------HEKMQEQEK 788 Query: 371 LQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNL 430 + + EK + E +R Q E+++ + + +++ Q + G EE + ++ Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848 Query: 431 EEKVRELRETVGDLEAMNEMNDEL---QENARETELELREQ 468 EEK+ E + G E M E +++ +E RE E ++R Q Sbjct: 849 EEKMEEKMQ--GQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887 Score = 33.1 bits (74), Expect = 1.7 Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 5/102 (4%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 983 K+ ++E ++E ++ + + E L E ++ E+K+ +D +ER+ + RL E + Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM----RDQEERMWEQDERLREKEE 411 Query: 984 LLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTI 1025 +R++EK +E+ ++ ++ + E EK Q Q + I Sbjct: 412 RMREQEKMWEQ-VEKMREEKKMQEQEKKTRDQEEKMQEEERI 452 Score = 32.0 bits (71), Expect = 3.8 Identities = 22/103 (21%), Positives = 54/103 (52%), Gaps = 4/103 (3%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV---QTRLEE 980 K+ + E++ +E +K ++ + E + E ++ E+K+ ++ E+ EK+ + ++ E Sbjct: 708 KMREEESM-REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766 Query: 981 TQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023 Q L +KEK +E Q I + E + + ++++ Q ++ Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809 Score = 31.6 bits (70), Expect = 5.0 Identities = 23/114 (20%), Positives = 56/114 (49%), Gaps = 13/114 (11%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKV--------- 974 ++ +RE ++E ++ ++ + E++ E ++ E+K+ + E+ EK+ Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649 Query: 975 -QTRLEETQALLRKKEKEFEETMDALQADIDQLEA---EKAELKQRLNSQSKRT 1024 + ++ E Q L +KEK +E Q + + E E+ +++++ Q K+T Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703 Score = 30.8 bits (68), Expect = 8.5 Identities = 23/112 (20%), Positives = 49/112 (43%), Gaps = 9/112 (8%) Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQA 983 K+ D+E + E + L+ K E + E +EK + E+ + Q + + Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450 Query: 984 LLRKKEKEFEETMDALQADIDQL---------EAEKAELKQRLNSQSKRTIE 1026 +R++EK+ E + ++ +++ + EK +QRL Q ++ E Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502 >gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo sapiens] Length = 1939 Score = 91.3 bits (225), Expect = 5e-18 Identities = 199/973 (20%), Positives = 384/973 (39%), Gaps = 169/973 (17%) Query: 190 LPSPSKEEEGLRAQVRDLEEKL----ETLRLKRAEDKA-------KLKELEKHKIQLEQV 238 L KE+ +V++L E++ ET+ E KA L +L+ + ++ + Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024 Query: 239 QEWKSKMQEQQADLQRRLKEARK------EAKEALE-----AKERYMEEMADTADA---- 283 + K K+++Q DL+ L++ +K AK LE A+E M+ D Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084 Query: 284 ----IEMATLDKEMAEERA--ESLQQEVEALKERVDELTTDLEI---LKAEIEEKGSD-- 332 EM+ L ++ +E+A LQ++++ L+ R++EL ++E +A+ E++ SD Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144 Query: 333 -------------GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKK- 378 G A+S Q++ +++ A + RDL + Q L +K Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKHA 1201 Query: 379 ------NQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA----EEMVEMLTDRNL 428 ++++ +++ +++L++E S+ + ID+L ++ A E+M L D+ Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261 Query: 429 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 488 ++ K E + + DL A LQ + E +L E+ + R Q + +E Sbjct: 1262 EIKTKEEEQQRLINDLTAQRA---RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318 Query: 489 TVADYQQTIKKYRQLTAHLQD-------VNRELTNQQEASVERQQ---QPPPETFDFKIK 538 ++ IK L LQ + + +QEA E Q+ + E ++ K Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378 Query: 539 FAETKAHAKAIEMELRQMEVAQ----ANRHMSLLTA---FMPDSFLRPGGDHDCVLVLLL 591 + ET A + E+E + ++AQ A H+ + A + + R + + +++ + Sbjct: 1379 Y-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437 Query: 592 MPRLICKAELIRKQAQEKF--ELSENCSERPG-LRGAAGEQLSFAAGL-----VYSLSLL 643 C A +++ +K E + C E L + E S + L Y SL Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497 Query: 644 QA-TLHRYEHALSQCSVDVYKKVGS----------LYPEMSAHERSLDFLIELLHKDQLD 692 Q TL R L Q D+ +++ + ++ + L +E Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557 Query: 693 ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVG------R 746 E + + + + +AE+ E+ +HI+ +S + E+ R Sbjct: 1558 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617 Query: 747 LRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDT 806 L+ ++G L ++E + + + R T A L + D Sbjct: 1618 LKKKMEGD---------LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL----HLDDA 1664 Query: 807 LL---DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS 863 L D ++ L V + A +L A L + E A +EL ASE++ Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL-LDASERV------ 1717 Query: 864 SPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGL 923 + L LI+T KL T + + + + E + E +A + ITDA + Sbjct: 1718 ---QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAAMMAE 1771 Query: 924 KLEDRETVIKELKKSLKIKGEELSEANVRLSLLEK-----------KLDSAAKDADERIE 972 +L+ + L++ K + + + RL E+ KL++ ++ + +E Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831 Query: 973 KVQTRLEETQALLRKKEKEFEE-----------------TMDALQADID--QLEAEKAEL 1013 Q R E LRK E++ +E +D LQA + + +AE+AE Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891 Query: 1014 KQRLNSQSKRTIE 1026 + +N R I+ Sbjct: 1892 QSNVNLSKFRRIQ 1904 Score = 89.0 bits (219), Expect = 3e-17 Identities = 171/855 (20%), Positives = 345/855 (40%), Gaps = 107/855 (12%) Query: 188 PPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQ----VQEWKS 243 P L S E+E + +++E+ E + + A+ +AK KELE+ + L Q +Q Sbjct: 842 PLLKSAETEKE-----MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896 Query: 244 KMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQ 303 + AD + R + K K LEAK + + E A+ + I K+ L+ Sbjct: 897 AEADSLADAEERCDQLIK-TKIQLEAKIKEVTERAEDEEEINAELTAKK------RKLED 949 Query: 304 EVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSS 363 E LK+ +D DLE+ A++E+ + A+ ++K L E+ A L + + ++ + Sbjct: 950 ECSELKKDID----DLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TK 998 Query: 364 EKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEML 423 EK + L E Q L+ ++ + +++ L++A+ +++ + ++ +L E+ + M Sbjct: 999 EK------KALQEAHQQTLDDLQAEEDKV-NTLTKAKIKLEQQVDDLEGSLEQEKKIRMD 1051 Query: 424 TDR-NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 482 +R LE ++ +E+ D+E + DE + L+ +++ A + QK+ Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKK 1111 Query: 483 VEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAET 542 ++ Q + + ++ I+ R A + +L+ + E ER ++ T + Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT---SAQIEMN 1168 Query: 543 KAHAKAIEMELRQMEVA--QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAE 600 K + R +E A Q + L DS G D + + K + Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV--------KQK 1220 Query: 601 LIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVD 660 L +++++ K E+ + S + A G L LS ++ + ++ D Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN----D 1276 Query: 661 VYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPE 720 + + L E + R LD KD L V L++ + + +Q E Sbjct: 1277 LTAQRARLQTESGEYSRQLD------EKDTL-----VSQLSRGKQAF--------TQQIE 1317 Query: 721 DCTMQLADHIKFTQS---ALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQF 777 + QL + IK + AL + LR + QEA A L R + + S++ Q+ Sbjct: 1318 ELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAK--AELQRAMSKANSEVAQW 1375 Query: 778 CKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 K TDA Q ++ L + +K L + +E A A L + Sbjct: 1376 RTKYE-----TDA----------IQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERP 897 + L +E+L E +C L + E + E Sbjct: 1421 TKQRLQNEVEDLMIDV-------------ERTNAACAALDKKQRNFDKILAEWKQKCEET 1467 Query: 898 PSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLE 957 ++ + + +L E+ + + D+ +K K+L+ + +L+E Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527 Query: 958 KKLDSAAKDADERIEKVQTRLEETQALLRKKEKE---FEETMDALQADIDQLEAEKAELK 1014 +L+ K ++ ++Q LEE +A L +E + + ++ +++++D+ AEK E Sbjct: 1528 HELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1587 Query: 1015 QRLNSQSKRTIEGLR 1029 ++ R +E ++ Sbjct: 1588 DQMKRNHIRIVESMQ 1602 Score = 55.1 bits (131), Expect = 4e-07 Identities = 128/604 (21%), Positives = 239/604 (39%), Gaps = 82/604 (13%) Query: 442 GDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYR 501 G L + EM DE + +L R Q G R +++ +E++ Q ++ + Sbjct: 772 GLLGLLEEMRDE-----KLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFM 826 Query: 502 QLT--AHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVA 559 + ++ + + A E++ E F+ K K K AK E+E + + + Sbjct: 827 NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFE-KTKEELAKTEAKRKELEEKMVTLM 885 Query: 560 QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSER 619 Q + L DS + C ++ +L K + + ++A+++ E++ +E Sbjct: 886 QEKNDLQLQVQAEADSLA--DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN---AEL 940 Query: 620 PGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSL 679 + ++ S + L L A + + +HA KV +L EM+ + ++ Sbjct: 941 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDETI 993 Query: 680 DFL------IELLHKDQLD----ETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADH 729 L ++ H+ LD E V LTKA I L +Q +D L Sbjct: 994 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA--------KIKLEQQVDDLEGSLEQE 1045 Query: 730 IKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTD 789 K + +L L+ QE+T D+E + + KK M G Sbjct: 1046 KKIRMD----LERAKRKLEGDLKLAQEST------MDIENDKQQLDEKLKKKEFEMSGLQ 1095 Query: 790 APGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEEL 849 + I A G Q+ + K L + L+E A A + L LEE+ Sbjct: 1096 SK-IEDEQALGMQLQKKI----KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150 Query: 850 AFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPV--ELR 907 + + E G +S+ E MNK +E E+ R + + E Sbjct: 1151 SERLEEA--GGATSAQIE------------MNK----KREAEFQKMRRDLEEATLQHEAT 1192 Query: 908 AAALRAEITDAEG-LGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKD 966 AA LR + D+ LG ++++ + V ++L+K E SE + + L +++ +K Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEK-------EKSEMKMEIDDLASNMETVSK- 1244 Query: 967 ADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIE 1026 A +EK+ LE+ + ++ KE+E + ++ L A +L+ E E ++L+ + + Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304 Query: 1027 GLRG 1030 RG Sbjct: 1305 LSRG 1308 Score = 55.1 bits (131), Expect = 4e-07 Identities = 52/278 (18%), Positives = 129/278 (46%), Gaps = 13/278 (4%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256 ++ LR+Q DL+E+L + + +A+++EL + LEQ + + +++ D R+ Sbjct: 1662 DDALRSQ-EDLKEQLAMVERRANLLQAEIEEL---RATLEQTERSRKIAEQELLDASERV 1717 Query: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV---D 313 + + + K++ +++ +E + AEE+A+ + + E + Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777 Query: 314 ELTTDLEILKAEIEEKGSD-----GAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEH 368 + + LE +K +E+ D A LK ++Q +L+ + + SE++ + Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837 Query: 369 VKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNL 428 V+ K + K ++++ + Q E ++ + + + +D+L+ +V + E E ++ NL Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897 Query: 429 NLEEKVR-ELRETVGDLEAMNEMNDELQENARETELEL 465 + +++ EL E + ++L+ +RE ++ Sbjct: 1898 SKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935 Score = 53.5 bits (127), Expect = 1e-06 Identities = 54/257 (21%), Positives = 115/257 (44%), Gaps = 40/257 (15%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-------------HKIQLEQVQEW 241 + +E L+ Q+ +E + L+ + E +A L++ E+ ++QL Q Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725 Query: 242 -----KSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEE 296 K K++ + +Q +++ +EA+ A E ++ + + A A+ ++ E Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785 Query: 297 RAESLQQEVEALKERVDELTT------DLEILKAEIEEKGSDGAASSYQLKQLEE-QNAR 349 ++L+Q V+ L+ R+DE +I K E + +G S Q + +E + R Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845 Query: 350 LKDALVRMRDLSSSEKQEHV-KLQKLMEKKNQELEVVRQQRE--------------RLQE 394 + V+ + E ++++ +LQ L++K +++ ++Q E R+Q Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905 Query: 395 ELSQAESTIDELKEQVD 411 EL +AE D + QV+ Sbjct: 1906 ELEEAEERADIAESQVN 1922 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 91.3 bits (225), Expect = 5e-18 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E E Q + LEE+L L+ + A K +ELE +L +V+ + +A + Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 310 + +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837 Query: 311 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 356 ++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L + Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 416 +R S SE +E++ +E +QR +++EE+ +++ ++ AA G Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476 E+ L N E+ +R + +LEA + +E R E E R Q +A Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998 Query: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 535 EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048 Query: 536 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 595 AE KAHA A++ + ++++ + S+L G+ + R Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089 Query: 596 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 654 +AE R QA+ E + E L+ +A EQ A + L+ + Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 655 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 713 +Q ++ + EM H++ + + K Q+++ + L + + ++L Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207 Query: 714 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 773 L + T + A + L + V++ L L+ EA + AL+LRD + + Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265 Query: 774 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 833 +++ +K++ QV++ A VAA A + Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294 Query: 834 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 891 LAE + AL E K Q T + E L+Q + + A +QE Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348 Query: 892 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 950 D E+ A AE T L+ E R+ + + LK++ E+S A Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1007 R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456 Query: 1008 AEKAELKQ-----RLNSQSKRTIE 1026 EK +L+Q +L S+ +T++ Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480 Score = 86.7 bits (213), Expect = 1e-16 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%) Query: 195 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 +EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ + Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663 Query: 254 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 285 ++ +EA +EA+ +A+E+ + +E+ E Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723 Query: 286 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 334 +++ EE LQ+E A ++ EL +L ++AE+ EE S Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783 Query: 335 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 374 S +L ++L E+ ARL+ + R R L+ + + E V +KL Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843 Query: 375 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 415 +++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903 Query: 416 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 461 +E +VE + +EE++ L+ + G E E+ ++ NA +T Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962 Query: 462 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 511 ELE Q +A R REA++RV+ A +E + +++ +L A +++ Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021 Query: 512 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 571 R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079 Query: 572 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 630 G+ + R +AE R QA+ E + E L+ +A EQ Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125 Query: 631 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 690 A + L+ + +Q ++ + EM H++ + L K Q Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183 Query: 691 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 749 +++ + L + + ++L L + T + A + L + V++ L + Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 808 L+ EA + AL+LRD + + +++ +K+++ +A + A ++ Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299 Query: 809 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 868 D + +L+E A + AE E L+ +ELA + + ++ + Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 922 L + T+ A ++ E AE K E+ A RAE AE +G Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414 Query: 923 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 972 KL E +E L ++L+I+ E L EA L ++KL AK + E Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474 Query: 973 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 ++QT L+ETQAL ++ F D+L +E EKA+L+Q Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518 Score = 85.1 bits (209), Expect = 4e-16 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 250 +K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+ Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075 Query: 251 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 308 L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135 Query: 309 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 360 KE E + +A + +K + A K E+ Q A+++ L +R L Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 ++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253 Query: 421 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 477 +L D++ L+E+ ++++ + ++ E + E +L +Q +A ++ Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313 Query: 478 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 523 E + V+ A A+ QQ + ++ LQ+ ++ Q EA + Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373 Query: 524 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 573 RQ + E K++ AE ++A A+A E R Q E H + L T Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 630 R DHD + + L + E ++++A Q K E + + L+ Q Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493 Query: 631 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 SF L SLLQ + + + L Q D K L E ++ ++ Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542 Score = 84.7 bits (208), Expect = 5e-16 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++ Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+ Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 L + +EK + Q +Q + RL++A+ + EK++ + KL+ Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 + K++E++ V QQ + LQE + +S + E D+ L E +E LE+ Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519 Query: 436 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 495 ++ V + + E Q+ + L ++ A R EA++ V QE + QQ Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575 Query: 496 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 ++ RQ L + N+ L Q + E+ + Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606 Score = 84.0 bits (206), Expect = 8e-16 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 255 + ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++A E ++A+ E A+E L E AE R Q EVE ++ L Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++ Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623 Query: 375 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424 E+ +ELE +R Q E + ++ S A++ ++ KE+ + E Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683 Query: 425 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 479 R L E+ E + + + A + EL ETE + R+ L+ AR+ REA Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743 Query: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 539 + QE A+ + + L A E + E S +R + E F+ + Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799 Query: 540 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 598 AE A +A+ E RQ ++A+ + R + + VL +L Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842 Query: 599 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 658 E R + + + L E +E LR A ++ R E +Q Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888 Query: 659 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ +++ L + L+E D L + VE A+K + AE Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943 Query: 719 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 778 + +E+GR+R+ A D E + RQ Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976 Query: 779 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 838 + RR + + +LA + + + + + A ++E A+ + AE Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030 Query: 839 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 E L + A +A E+ + + L+Q+ S +++L + A Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E E AA R ++ +AE L E++ + + + + +E + R + Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206 Query: 1015 QRLNSQSKRTIEGLR 1029 + L E R Sbjct: 2207 EELQRLKAEATEAAR 2221 Score = 82.4 bits (202), Expect = 2e-15 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%) Query: 201 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ + Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 319 ++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475 Query: 320 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 371 + L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525 Query: 372 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 + EK+ Q LE +R Q E + L QAE E QV AL + Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 L+ K E LE LQE +LRE+ + + EA++ E A+ Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q + +L ++V ++ + Q A E+Q++ E + KA Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680 Query: 550 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 E +RQ E+A + R ++ TA RL + ELIR + Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719 Query: 606 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 665 A E + +R L AA L+A L + ++ V + K Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772 Query: 666 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + S E+S L ++ +E + L + K + L A Q + Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 780 LA+ +L A + + T+ + L++ E +R+ + Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875 Query: 781 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 RRR+ A I LA + SD+ L+ +K L V L++ +++A A Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 895 E E E G S+ + LR + + + +LA + +AE Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987 Query: 896 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 950 K E AA R A + + E L K+E+ RE +E + L++ E A Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1010 RL EK + A ++ +++Q L++ Q++L + E E A + EAE+ Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095 Query: 1011 AELK-QRLNSQSKRTIE 1026 A ++ +R +QS+R +E Sbjct: 2096 ARVQAEREAAQSRRQVE 2112 Score = 68.2 bits (165), Expect = 5e-11 Identities = 184/934 (19%), Positives = 352/934 (37%), Gaps = 120/934 (12%) Query: 190 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 235 LP PS LR+ QVR L EKL+T+ L + + L H+ QL Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112 Query: 236 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 ++ Q + + E +A + LK+ R +A+ + +E+ + E + Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 E ++ V L ER + ++ + E+E+ G Y + + A L+DA Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 408 R + + + +++ + ++ LE + + E+++E A+ I+ +K+ Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288 Query: 409 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 + G+E +++ D + E + + + +E + Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348 Query: 456 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 515 A + E RE+L A + + ++ EA + A ++ K+ + Q + E+ Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402 Query: 516 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 573 ++EA+V+ QQQ E + +E + AKA + E + + + ++ + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 623 + + GG + L +AE ++QAQE+ E + R Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 681 A E + +L L+ E L Q V+ ++V + +RS + Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576 Query: 682 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 738 ++ ++T +E + +H+ L E+ E Q A+ + + A L+ Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 739 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 776 ++ LR LQ + A +L + E + Q Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 777 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 830 +K R+ GT + A ++T R+ L +A LQ AAAA Q Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 881 L A LA+ + L A +A E+ T S + L + L + Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811 Query: 882 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 936 + Q E DA R ++ V A E T+AE + LK ++ E ++ L Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870 Query: 937 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + + L E A + +E++L K +D +E+ + +E+T ++ ++ EE Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + AL+A ++ A KAEL+ L + LR Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960 Score = 66.2 bits (160), Expect = 2e-10 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 ++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 ++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + + Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 371 +E KA++E+ D A + QL++ E+Q + + R R ++S E +++H + Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562 Query: 372 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 ++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 487 + + + R+ + A E R+ ++L AG E +R+ Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676 Query: 488 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 529 TV + ++ ++ Y Q + + + + TN++ A+++RQ P Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723 Score = 60.1 bits (144), Expect = 1e-08 Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 121/1006 (12%) Query: 247 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 301 EQ A + R + E K+ R E +T + LDKE A E A+ + Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027 Query: 302 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 349 Q EVE L + V L+ + E + A E + S +L+Q+ +A + Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087 Query: 350 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404 LK + +R +E+ +E +K + + ELE + ++L+ + + T D Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147 Query: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 460 L++++ GA+E+ E L R+ + +V RE V L +A+ D Q + Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204 Query: 461 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 516 +L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264 Query: 517 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 576 +E +Q D++++ KA + + ++ +V + S++ ++ Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318 Query: 577 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 636 LR H L L + +E +R+ +E+ + +E L L Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375 Query: 637 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 696 + + +A R L Q + + + +RS+ ++ QL ++ Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430 Query: 697 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 756 E KA AE E +++ + I+ + L+ + +GG E Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472 Query: 757 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 811 AL R + E ++ +++RR++ A + +V ++ + + Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532 Query: 812 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 866 + L + + + A +L E + ALE A ++ +S + Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 E Q ++ ++ + + A + + +AER + EL L+A E L L+L+ Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647 Query: 927 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 976 E K L ++ K +E +E R E++ + A++ +EK Q Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707 Query: 977 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1034 RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E + Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762 Query: 1035 GIATLVSGIAGGAIPGQAPGSVPGPGL---------VKDSPLLLQQISAMRLHISQLQHE 1085 + L++ A ++ L + + L+ ++ QL E Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822 Query: 1086 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1143 ++ + A+ + LA KL+ G + L A ++ E L +L+ Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1189 R A A + E++AQL+ SD+ + + ++++T+ QR Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 91.3 bits (225), Expect = 5e-18 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E E Q + LEE+L L+ + A K +ELE +L +V+ + +A + Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1781 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 310 + +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841 Query: 311 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 356 ++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L + Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 416 +R S SE +E++ +E +QR +++EE+ +++ ++ AA G Sbjct: 1902 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1945 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476 E+ L N E+ +R + +LEA + +E R E E R Q +A Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2002 Query: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 535 EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q Sbjct: 2003 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2052 Query: 536 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 595 AE KAHA A++ + ++++ + S+L G+ + R Sbjct: 2053 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2093 Query: 596 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 654 +AE R QA+ E + E L+ +A EQ A + L+ + Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153 Query: 655 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 713 +Q ++ + EM H++ + + K Q+++ + L + + ++L Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2211 Query: 714 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 773 L + T + A + L + V++ L L+ EA + AL+LRD + + Sbjct: 2212 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2269 Query: 774 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 833 +++ +K++ QV++ A VAA A + Sbjct: 2270 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2298 Query: 834 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 891 LAE + AL E K Q T + E L+Q + + A +QE Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2352 Query: 892 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 950 D E+ A AE T L+ E R+ + + LK++ E+S A Sbjct: 2353 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1007 R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460 Query: 1008 AEKAELKQ-----RLNSQSKRTIE 1026 EK +L+Q +L S+ +T++ Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ 2484 Score = 86.7 bits (213), Expect = 1e-16 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%) Query: 195 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 +EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ + Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1667 Query: 254 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 285 ++ +EA +EA+ +A+E+ + +E+ E Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727 Query: 286 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 334 +++ EE LQ+E A ++ EL +L ++AE+ EE S Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787 Query: 335 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 374 S +L ++L E+ ARL+ + R R L+ + + E V +KL Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847 Query: 375 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 415 +++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907 Query: 416 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 461 +E +VE + +EE++ L+ + G E E+ ++ NA +T Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1966 Query: 462 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 511 ELE Q +A R REA++RV+ A +E + +++ +L A +++ Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2025 Query: 512 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 571 R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2083 Query: 572 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 630 G+ + R +AE R QA+ E + E L+ +A EQ Sbjct: 2084 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129 Query: 631 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 690 A + L+ + +Q ++ + EM H++ + L K Q Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2187 Query: 691 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 749 +++ + L + + ++L L + T + A + L + V++ L + Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2245 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 808 L+ EA + AL+LRD + + +++ +K+++ +A + A ++ Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2303 Query: 809 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 868 D + +L+E A + AE E L+ +ELA + + ++ + Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2360 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 922 L + T+ A ++ E AE K E+ A RAE AE +G Sbjct: 2361 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418 Query: 923 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 972 KL E +E L ++L+I+ E L EA L ++KL AK + E Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478 Query: 973 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 ++QT L+ETQAL ++ F D+L +E EKA+L+Q Sbjct: 2479 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2522 Score = 85.1 bits (209), Expect = 4e-16 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 250 +K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+ Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2079 Query: 251 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 308 L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139 Query: 309 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 360 KE E + +A + +K + A K E+ Q A+++ L +R L Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 ++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2257 Query: 421 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 477 +L D++ L+E+ ++++ + ++ E + E +L +Q +A ++ Sbjct: 2258 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317 Query: 478 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 523 E + V+ A A+ QQ + ++ LQ+ ++ Q EA + Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377 Query: 524 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 573 RQ + E K++ AE ++A A+A E R Q E H + L T Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 630 R DHD + + L + E ++++A Q K E + + L+ Q Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497 Query: 631 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 SF L SLLQ + + + L Q D K L E ++ ++ Sbjct: 2498 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546 Score = 84.7 bits (208), Expect = 5e-16 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++ Sbjct: 2302 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+ Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2417 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 L + +EK + Q +Q + RL++A+ + EK++ + KL+ Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2473 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 + K++E++ V QQ + LQE + +S + E D+ L E +E LE+ Sbjct: 2474 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2523 Query: 436 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 495 ++ V + + E Q+ + L ++ A R EA++ V QE + QQ Sbjct: 2524 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2579 Query: 496 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 ++ RQ L + N+ L Q + E+ + Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610 Score = 84.0 bits (206), Expect = 8e-16 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 255 + ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++A E ++A+ E A+E L E AE R Q EVE ++ L Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1571 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++ Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1627 Query: 375 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424 E+ +ELE +R Q E + ++ S A++ ++ KE+ + E Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687 Query: 425 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 479 R L E+ E + + + A + EL ETE + R+ L+ AR+ REA Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747 Query: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 539 + QE A+ + + L A E + E S +R + E F+ + Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1803 Query: 540 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 598 AE A +A+ E RQ ++A+ + R + + VL +L Sbjct: 1804 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1846 Query: 599 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 658 E R + + + L E +E LR A ++ R E +Q Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1892 Query: 659 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ +++ L + L+E D L + VE A+K + AE Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1947 Query: 719 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 778 + +E+GR+R+ A D E + RQ Sbjct: 1948 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1980 Query: 779 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 838 + RR + + +LA + + + + + A ++E A+ + AE Sbjct: 1981 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2034 Query: 839 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 E L + A +A E+ + + L+Q+ S +++L + A Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E E AA R ++ +AE L E++ + + + + +E + R + Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2210 Query: 1015 QRLNSQSKRTIEGLR 1029 + L E R Sbjct: 2211 EELQRLKAEATEAAR 2225 Score = 82.4 bits (202), Expect = 2e-15 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%) Query: 201 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ + Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 319 ++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1479 Query: 320 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 371 + L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L Sbjct: 1480 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1529 Query: 372 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 + EK+ Q LE +R Q E + L QAE E QV AL + Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1581 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 L+ K E LE LQE +LRE+ + + EA++ E A+ Sbjct: 1582 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1634 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q + +L ++V ++ + Q A E+Q++ E + KA Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1684 Query: 550 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 E +RQ E+A + R ++ TA RL + ELIR + Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1723 Query: 606 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 665 A E + +R L AA L+A L + ++ V + K Sbjct: 1724 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1776 Query: 666 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + S E+S L ++ +E + L + K + L A Q + Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 780 LA+ +L A + + T+ + L++ E +R+ + Sbjct: 1837 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879 Query: 781 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 RRR+ A I LA + SD+ L+ +K L V L++ +++A A Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1937 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 895 E E E G S+ + LR + + + +LA + +AE Sbjct: 1938 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991 Query: 896 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 950 K E AA R A + + E L K+E+ RE +E + L++ E A Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2048 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1010 RL EK + A ++ +++Q L++ Q++L + E E A + EAE+ Sbjct: 2049 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2099 Query: 1011 AELK-QRLNSQSKRTIE 1026 A ++ +R +QS+R +E Sbjct: 2100 ARVQAEREAAQSRRQVE 2116 Score = 68.2 bits (165), Expect = 5e-11 Identities = 184/934 (19%), Positives = 352/934 (37%), Gaps = 120/934 (12%) Query: 190 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 235 LP PS LR+ QVR L EKL+T+ L + + L H+ QL Sbjct: 1057 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1116 Query: 236 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 ++ Q + + E +A + LK+ R +A+ + +E+ + E + Sbjct: 1117 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 E ++ V L ER + ++ + E+E+ G Y + + A L+DA Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1232 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 408 R + + + +++ + ++ LE + + E+++E A+ I+ +K+ Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292 Query: 409 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 + G+E +++ D + E + + + +E + Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352 Query: 456 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 515 A + E RE+L A + + ++ EA + A ++ K+ + Q + E+ Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1406 Query: 516 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 573 ++EA+V+ QQQ E + +E + AKA + E + + + ++ + Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 623 + + GG + L +AE ++QAQE+ E + R Sbjct: 1467 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 681 A E + +L L+ E L Q V+ ++V + +RS + Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1580 Query: 682 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 738 ++ ++T +E + +H+ L E+ E Q A+ + + A L+ Sbjct: 1581 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636 Query: 739 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 776 ++ LR LQ + A +L + E + Q Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696 Query: 777 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 830 +K R+ GT + A ++T R+ L +A LQ AAAA Q Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 881 L A LA+ + L A +A E+ T S + L + L + Sbjct: 1757 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815 Query: 882 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 936 + Q E DA R ++ V A E T+AE + LK ++ E ++ L Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1874 Query: 937 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + + L E A + +E++L K +D +E+ + +E+T ++ ++ EE Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1930 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + AL+A ++ A KAEL+ L + LR Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964 Score = 66.2 bits (160), Expect = 2e-10 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 ++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2461 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 ++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + + Sbjct: 2462 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 371 +E KA++E+ D A + QL++ E+Q + + R R ++S E +++H + Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2566 Query: 372 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 ++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2623 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 487 + + + R+ + A E R+ ++L AG E +R+ Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2680 Query: 488 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 529 TV + ++ ++ Y Q + + + + TN++ A+++RQ P Sbjct: 2681 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2727 Score = 60.1 bits (144), Expect = 1e-08 Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 121/1006 (12%) Query: 247 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 301 EQ A + R + E K+ R E +T + LDKE A E A+ + Sbjct: 977 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1031 Query: 302 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 349 Q EVE L + V L+ + E + A E + S +L+Q+ +A + Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091 Query: 350 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404 LK + +R +E+ +E +K + + ELE + ++L+ + + T D Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151 Query: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 460 L++++ GA+E+ E L R+ + +V RE V L +A+ D Q + Sbjct: 1152 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208 Query: 461 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 516 +L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268 Query: 517 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 576 +E +Q D++++ KA + + ++ +V + S++ ++ Sbjct: 1269 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1322 Query: 577 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 636 LR H L L + +E +R+ +E+ + +E L L Sbjct: 1323 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379 Query: 637 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 696 + + +A R L Q + + + +RS+ ++ QL ++ Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1434 Query: 697 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 756 E KA AE E +++ + I+ + L+ + +GG E Sbjct: 1435 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1476 Query: 757 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 811 AL R + E ++ +++RR++ A + +V ++ + + Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536 Query: 812 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 866 + L + + + A +L E + ALE A ++ +S + Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 E Q ++ ++ + + A + + +AER + EL L+A E L L+L+ Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1651 Query: 927 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 976 E K L ++ K +E +E R E++ + A++ +EK Q Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711 Query: 977 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1034 RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E + Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1766 Query: 1035 GIATLVSGIAGGAIPGQAPGSVPGPGL---------VKDSPLLLQQISAMRLHISQLQHE 1085 + L++ A ++ L + + L+ ++ QL E Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826 Query: 1086 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1143 ++ + A+ + LA KL+ G + L A ++ E L +L+ Sbjct: 1827 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1878 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1189 R A A + E++AQL+ SD+ + + ++++T+ QR Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 91.3 bits (225), Expect = 5e-18 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E E Q + LEE+L L+ + A K +ELE +L +V+ + +A + Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1777 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 310 + +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837 Query: 311 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 356 ++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L + Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 416 +R S SE +E++ +E +QR +++EE+ +++ ++ AA G Sbjct: 1898 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1941 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476 E+ L N E+ +R + +LEA + +E R E E R Q +A Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1998 Query: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 535 EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q Sbjct: 1999 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2048 Query: 536 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 595 AE KAHA A++ + ++++ + S+L G+ + R Sbjct: 2049 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2089 Query: 596 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 654 +AE R QA+ E + E L+ +A EQ A + L+ + Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149 Query: 655 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 713 +Q ++ + EM H++ + + K Q+++ + L + + ++L Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2207 Query: 714 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 773 L + T + A + L + V++ L L+ EA + AL+LRD + + Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2265 Query: 774 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 833 +++ +K++ QV++ A VAA A + Sbjct: 2266 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2294 Query: 834 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 891 LAE + AL E K Q T + E L+Q + + A +QE Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2348 Query: 892 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 950 D E+ A AE T L+ E R+ + + LK++ E+S A Sbjct: 2349 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1007 R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456 Query: 1008 AEKAELKQ-----RLNSQSKRTIE 1026 EK +L+Q +L S+ +T++ Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ 2480 Score = 86.7 bits (213), Expect = 1e-16 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%) Query: 195 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 +EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ + Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1663 Query: 254 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 285 ++ +EA +EA+ +A+E+ + +E+ E Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723 Query: 286 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 334 +++ EE LQ+E A ++ EL +L ++AE+ EE S Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783 Query: 335 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 374 S +L ++L E+ ARL+ + R R L+ + + E V +KL Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843 Query: 375 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 415 +++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903 Query: 416 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 461 +E +VE + +EE++ L+ + G E E+ ++ NA +T Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1962 Query: 462 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 511 ELE Q +A R REA++RV+ A +E + +++ +L A +++ Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2021 Query: 512 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 571 R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2079 Query: 572 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 630 G+ + R +AE R QA+ E + E L+ +A EQ Sbjct: 2080 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125 Query: 631 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 690 A + L+ + +Q ++ + EM H++ + L K Q Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2183 Query: 691 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 749 +++ + L + + ++L L + T + A + L + V++ L + Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2241 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 808 L+ EA + AL+LRD + + +++ +K+++ +A + A ++ Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2299 Query: 809 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 868 D + +L+E A + AE E L+ +ELA + + ++ + Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2356 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 922 L + T+ A ++ E AE K E+ A RAE AE +G Sbjct: 2357 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414 Query: 923 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 972 KL E +E L ++L+I+ E L EA L ++KL AK + E Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474 Query: 973 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 ++QT L+ETQAL ++ F D+L +E EKA+L+Q Sbjct: 2475 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2518 Score = 85.1 bits (209), Expect = 4e-16 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 250 +K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+ Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2075 Query: 251 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 308 L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135 Query: 309 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 360 KE E + +A + +K + A K E+ Q A+++ L +R L Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 ++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2253 Query: 421 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 477 +L D++ L+E+ ++++ + ++ E + E +L +Q +A ++ Sbjct: 2254 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313 Query: 478 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 523 E + V+ A A+ QQ + ++ LQ+ ++ Q EA + Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373 Query: 524 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 573 RQ + E K++ AE ++A A+A E R Q E H + L T Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 630 R DHD + + L + E ++++A Q K E + + L+ Q Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493 Query: 631 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 SF L SLLQ + + + L Q D K L E ++ ++ Sbjct: 2494 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542 Score = 84.7 bits (208), Expect = 5e-16 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++ Sbjct: 2298 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+ Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2413 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 L + +EK + Q +Q + RL++A+ + EK++ + KL+ Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2469 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 + K++E++ V QQ + LQE + +S + E D+ L E +E LE+ Sbjct: 2470 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2519 Query: 436 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 495 ++ V + + E Q+ + L ++ A R EA++ V QE + QQ Sbjct: 2520 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2575 Query: 496 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 ++ RQ L + N+ L Q + E+ + Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606 Score = 84.0 bits (206), Expect = 8e-16 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 255 + ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++A E ++A+ E A+E L E AE R Q EVE ++ L Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++ Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1623 Query: 375 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424 E+ +ELE +R Q E + ++ S A++ ++ KE+ + E Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683 Query: 425 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 479 R L E+ E + + + A + EL ETE + R+ L+ AR+ REA Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743 Query: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 539 + QE A+ + + L A E + E S +R + E F+ + Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1799 Query: 540 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 598 AE A +A+ E RQ ++A+ + R + + VL +L Sbjct: 1800 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1842 Query: 599 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 658 E R + + + L E +E LR A ++ R E +Q Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1888 Query: 659 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ +++ L + L+E D L + VE A+K + AE Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1943 Query: 719 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 778 + +E+GR+R+ A D E + RQ Sbjct: 1944 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1976 Query: 779 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 838 + RR + + +LA + + + + + A ++E A+ + AE Sbjct: 1977 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2030 Query: 839 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 E L + A +A E+ + + L+Q+ S +++L + A Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E E AA R ++ +AE L E++ + + + + +E + R + Sbjct: 2091 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2206 Query: 1015 QRLNSQSKRTIEGLR 1029 + L E R Sbjct: 2207 EELQRLKAEATEAAR 2221 Score = 82.4 bits (202), Expect = 2e-15 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%) Query: 201 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ + Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 319 ++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1475 Query: 320 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 371 + L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L Sbjct: 1476 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1525 Query: 372 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 + EK+ Q LE +R Q E + L QAE E QV AL + Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1577 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 L+ K E LE LQE +LRE+ + + EA++ E A+ Sbjct: 1578 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1630 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q + +L ++V ++ + Q A E+Q++ E + KA Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1680 Query: 550 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 E +RQ E+A + R ++ TA RL + ELIR + Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1719 Query: 606 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 665 A E + +R L AA L+A L + ++ V + K Sbjct: 1720 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1772 Query: 666 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + S E+S L ++ +E + L + K + L A Q + Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 780 LA+ +L A + + T+ + L++ E +R+ + Sbjct: 1833 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875 Query: 781 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 RRR+ A I LA + SD+ L+ +K L V L++ +++A A Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1933 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 895 E E E G S+ + LR + + + +LA + +AE Sbjct: 1934 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987 Query: 896 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 950 K E AA R A + + E L K+E+ RE +E + L++ E A Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2044 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1010 RL EK + A ++ +++Q L++ Q++L + E E A + EAE+ Sbjct: 2045 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2095 Query: 1011 AELK-QRLNSQSKRTIE 1026 A ++ +R +QS+R +E Sbjct: 2096 ARVQAEREAAQSRRQVE 2112 Score = 68.2 bits (165), Expect = 5e-11 Identities = 184/934 (19%), Positives = 352/934 (37%), Gaps = 120/934 (12%) Query: 190 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 235 LP PS LR+ QVR L EKL+T+ L + + L H+ QL Sbjct: 1053 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1112 Query: 236 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 ++ Q + + E +A + LK+ R +A+ + +E+ + E + Sbjct: 1113 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 E ++ V L ER + ++ + E+E+ G Y + + A L+DA Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1228 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 408 R + + + +++ + ++ LE + + E+++E A+ I+ +K+ Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288 Query: 409 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 + G+E +++ D + E + + + +E + Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348 Query: 456 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 515 A + E RE+L A + + ++ EA + A ++ K+ + Q + E+ Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1402 Query: 516 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 573 ++EA+V+ QQQ E + +E + AKA + E + + + ++ + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 623 + + GG + L +AE ++QAQE+ E + R Sbjct: 1463 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 681 A E + +L L+ E L Q V+ ++V + +RS + Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1576 Query: 682 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 738 ++ ++T +E + +H+ L E+ E Q A+ + + A L+ Sbjct: 1577 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632 Query: 739 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 776 ++ LR LQ + A +L + E + Q Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 777 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 830 +K R+ GT + A ++T R+ L +A LQ AAAA Q Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 881 L A LA+ + L A +A E+ T S + L + L + Sbjct: 1753 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811 Query: 882 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 936 + Q E DA R ++ V A E T+AE + LK ++ E ++ L Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1870 Query: 937 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + + L E A + +E++L K +D +E+ + +E+T ++ ++ EE Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1926 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + AL+A ++ A KAEL+ L + LR Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960 Score = 66.2 bits (160), Expect = 2e-10 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 ++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2457 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 ++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + + Sbjct: 2458 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 371 +E KA++E+ D A + QL++ E+Q + + R R ++S E +++H + Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2562 Query: 372 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 ++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2619 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 487 + + + R+ + A E R+ ++L AG E +R+ Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2676 Query: 488 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 529 TV + ++ ++ Y Q + + + + TN++ A+++RQ P Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2723 Score = 60.1 bits (144), Expect = 1e-08 Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 121/1006 (12%) Query: 247 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 301 EQ A + R + E K+ R E +T + LDKE A E A+ + Sbjct: 973 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1027 Query: 302 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 349 Q EVE L + V L+ + E + A E + S +L+Q+ +A + Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087 Query: 350 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404 LK + +R +E+ +E +K + + ELE + ++L+ + + T D Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147 Query: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 460 L++++ GA+E+ E L R+ + +V RE V L +A+ D Q + Sbjct: 1148 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204 Query: 461 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 516 +L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264 Query: 517 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 576 +E +Q D++++ KA + + ++ +V + S++ ++ Sbjct: 1265 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1318 Query: 577 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 636 LR H L L + +E +R+ +E+ + +E L L Sbjct: 1319 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375 Query: 637 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 696 + + +A R L Q + + + +RS+ ++ QL ++ Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1430 Query: 697 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 756 E KA AE E +++ + I+ + L+ + +GG E Sbjct: 1431 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1472 Query: 757 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 811 AL R + E ++ +++RR++ A + +V ++ + + Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532 Query: 812 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 866 + L + + + A +L E + ALE A ++ +S + Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 E Q ++ ++ + + A + + +AER + EL L+A E L L+L+ Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1647 Query: 927 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 976 E K L ++ K +E +E R E++ + A++ +EK Q Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707 Query: 977 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1034 RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E + Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1762 Query: 1035 GIATLVSGIAGGAIPGQAPGSVPGPGL---------VKDSPLLLQQISAMRLHISQLQHE 1085 + L++ A ++ L + + L+ ++ QL E Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822 Query: 1086 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1143 ++ + A+ + LA KL+ G + L A ++ E L +L+ Sbjct: 1823 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1874 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1189 R A A + E++AQL+ SD+ + + ++++T+ QR Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 91.3 bits (225), Expect = 5e-18 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E E Q + LEE+L L+ + A K +ELE +L +V+ + +A + Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1745 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 310 + +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805 Query: 311 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 356 ++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L + Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 416 +R S SE +E++ +E +QR +++EE+ +++ ++ AA G Sbjct: 1866 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 1909 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476 E+ L N E+ +R + +LEA + +E R E E R Q +A Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 1966 Query: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 535 EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q Sbjct: 1967 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2016 Query: 536 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 595 AE KAHA A++ + ++++ + S+L G+ + R Sbjct: 2017 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2057 Query: 596 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 654 +AE R QA+ E + E L+ +A EQ A + L+ + Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117 Query: 655 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 713 +Q ++ + EM H++ + + K Q+++ + L + + ++L Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2175 Query: 714 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 773 L + T + A + L + V++ L L+ EA + AL+LRD + + Sbjct: 2176 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2233 Query: 774 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 833 +++ +K++ QV++ A VAA A + Sbjct: 2234 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2262 Query: 834 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 891 LAE + AL E K Q T + E L+Q + + A +QE Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2316 Query: 892 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 950 D E+ A AE T L+ E R+ + + LK++ E+S A Sbjct: 2317 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1007 R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424 Query: 1008 AEKAELKQ-----RLNSQSKRTIE 1026 EK +L+Q +L S+ +T++ Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ 2448 Score = 86.7 bits (213), Expect = 1e-16 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%) Query: 195 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 +EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ + Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1631 Query: 254 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 285 ++ +EA +EA+ +A+E+ + +E+ E Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691 Query: 286 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 334 +++ EE LQ+E A ++ EL +L ++AE+ EE S Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751 Query: 335 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 374 S +L ++L E+ ARL+ + R R L+ + + E V +KL Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811 Query: 375 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 415 +++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871 Query: 416 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 461 +E +VE + +EE++ L+ + G E E+ ++ NA +T Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 1930 Query: 462 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 511 ELE Q +A R REA++RV+ A +E + +++ +L A +++ Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 1989 Query: 512 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 571 R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2047 Query: 572 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 630 G+ + R +AE R QA+ E + E L+ +A EQ Sbjct: 2048 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093 Query: 631 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 690 A + L+ + +Q ++ + EM H++ + L K Q Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2151 Query: 691 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 749 +++ + L + + ++L L + T + A + L + V++ L + Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2209 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 808 L+ EA + AL+LRD + + +++ +K+++ +A + A ++ Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2267 Query: 809 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 868 D + +L+E A + AE E L+ +ELA + + ++ + Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2324 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 922 L + T+ A ++ E AE K E+ A RAE AE +G Sbjct: 2325 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382 Query: 923 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 972 KL E +E L ++L+I+ E L EA L ++KL AK + E Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442 Query: 973 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 ++QT L+ETQAL ++ F D+L +E EKA+L+Q Sbjct: 2443 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2486 Score = 85.1 bits (209), Expect = 4e-16 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 250 +K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+ Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043 Query: 251 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 308 L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103 Query: 309 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 360 KE E + +A + +K + A K E+ Q A+++ L +R L Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 ++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2221 Query: 421 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 477 +L D++ L+E+ ++++ + ++ E + E +L +Q +A ++ Sbjct: 2222 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281 Query: 478 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 523 E + V+ A A+ QQ + ++ LQ+ ++ Q EA + Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341 Query: 524 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 573 RQ + E K++ AE ++A A+A E R Q E H + L T Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 630 R DHD + + L + E ++++A Q K E + + L+ Q Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461 Query: 631 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 SF L SLLQ + + + L Q D K L E ++ ++ Sbjct: 2462 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510 Score = 84.7 bits (208), Expect = 5e-16 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++ Sbjct: 2266 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+ Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2381 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 L + +EK + Q +Q + RL++A+ + EK++ + KL+ Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2437 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 + K++E++ V QQ + LQE + +S + E D+ L E +E LE+ Sbjct: 2438 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2487 Query: 436 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 495 ++ V + + E Q+ + L ++ A R EA++ V QE + QQ Sbjct: 2488 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2543 Query: 496 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 ++ RQ L + N+ L Q + E+ + Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574 Score = 84.0 bits (206), Expect = 8e-16 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 255 + ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++A E ++A+ E A+E L E AE R Q EVE ++ L Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1535 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++ Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1591 Query: 375 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424 E+ +ELE +R Q E + ++ S A++ ++ KE+ + E Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651 Query: 425 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 479 R L E+ E + + + A + EL ETE + R+ L+ AR+ REA Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711 Query: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 539 + QE A+ + + L A E + E S +R + E F+ + Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1767 Query: 540 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 598 AE A +A+ E RQ ++A+ + R + + VL +L Sbjct: 1768 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1810 Query: 599 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 658 E R + + + L E +E LR A ++ R E +Q Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 1856 Query: 659 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ +++ L + L+E D L + VE A+K + AE Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 1911 Query: 719 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 778 + +E+GR+R+ A D E + RQ Sbjct: 1912 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 1944 Query: 779 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 838 + RR + + +LA + + + + + A ++E A+ + AE Sbjct: 1945 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 1998 Query: 839 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 E L + A +A E+ + + L+Q+ S +++L + A Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E E AA R ++ +AE L E++ + + + + +E + R + Sbjct: 2059 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2174 Query: 1015 QRLNSQSKRTIEGLR 1029 + L E R Sbjct: 2175 EELQRLKAEATEAAR 2189 Score = 82.4 bits (202), Expect = 2e-15 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%) Query: 201 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ + Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 319 ++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1443 Query: 320 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 371 + L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L Sbjct: 1444 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1493 Query: 372 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 + EK+ Q LE +R Q E + L QAE E QV AL + Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1545 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 L+ K E LE LQE +LRE+ + + EA++ E A+ Sbjct: 1546 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1598 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q + +L ++V ++ + Q A E+Q++ E + KA Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1648 Query: 550 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 E +RQ E+A + R ++ TA RL + ELIR + Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1687 Query: 606 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 665 A E + +R L AA L+A L + ++ V + K Sbjct: 1688 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1740 Query: 666 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + S E+S L ++ +E + L + K + L A Q + Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 780 LA+ +L A + + T+ + L++ E +R+ + Sbjct: 1801 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843 Query: 781 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 RRR+ A I LA + SD+ L+ +K L V L++ +++A A Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 1901 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 895 E E E G S+ + LR + + + +LA + +AE Sbjct: 1902 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955 Query: 896 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 950 K E AA R A + + E L K+E+ RE +E + L++ E A Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2012 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1010 RL EK + A ++ +++Q L++ Q++L + E E A + EAE+ Sbjct: 2013 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2063 Query: 1011 AELK-QRLNSQSKRTIE 1026 A ++ +R +QS+R +E Sbjct: 2064 ARVQAEREAAQSRRQVE 2080 Score = 68.2 bits (165), Expect = 5e-11 Identities = 184/934 (19%), Positives = 352/934 (37%), Gaps = 120/934 (12%) Query: 190 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 235 LP PS LR+ QVR L EKL+T+ L + + L H+ QL Sbjct: 1021 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1080 Query: 236 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 ++ Q + + E +A + LK+ R +A+ + +E+ + E + Sbjct: 1081 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 E ++ V L ER + ++ + E+E+ G Y + + A L+DA Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1196 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 408 R + + + +++ + ++ LE + + E+++E A+ I+ +K+ Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256 Query: 409 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 + G+E +++ D + E + + + +E + Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316 Query: 456 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 515 A + E RE+L A + + ++ EA + A ++ K+ + Q + E+ Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1370 Query: 516 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 573 ++EA+V+ QQQ E + +E + AKA + E + + + ++ + Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 623 + + GG + L +AE ++QAQE+ E + R Sbjct: 1431 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1487 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 681 A E + +L L+ E L Q V+ ++V + +RS + Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1544 Query: 682 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 738 ++ ++T +E + +H+ L E+ E Q A+ + + A L+ Sbjct: 1545 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600 Query: 739 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 776 ++ LR LQ + A +L + E + Q Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660 Query: 777 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 830 +K R+ GT + A ++T R+ L +A LQ AAAA Q Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 881 L A LA+ + L A +A E+ T S + L + L + Sbjct: 1721 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779 Query: 882 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 936 + Q E DA R ++ V A E T+AE + LK ++ E ++ L Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 1838 Query: 937 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + + L E A + +E++L K +D +E+ + +E+T ++ ++ EE Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 1894 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + AL+A ++ A KAEL+ L + LR Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928 Score = 66.2 bits (160), Expect = 2e-10 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 ++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2425 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 ++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + + Sbjct: 2426 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 371 +E KA++E+ D A + QL++ E+Q + + R R ++S E +++H + Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2530 Query: 372 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 ++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2587 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 487 + + + R+ + A E R+ ++L AG E +R+ Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2644 Query: 488 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 529 TV + ++ ++ Y Q + + + + TN++ A+++RQ P Sbjct: 2645 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2691 Score = 60.1 bits (144), Expect = 1e-08 Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 121/1006 (12%) Query: 247 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 301 EQ A + R + E K+ R E +T + LDKE A E A+ + Sbjct: 941 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 995 Query: 302 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 349 Q EVE L + V L+ + E + A E + S +L+Q+ +A + Sbjct: 996 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055 Query: 350 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404 LK + +R +E+ +E +K + + ELE + ++L+ + + T D Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115 Query: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 460 L++++ GA+E+ E L R+ + +V RE V L +A+ D Q + Sbjct: 1116 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172 Query: 461 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 516 +L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232 Query: 517 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 576 +E +Q D++++ KA + + ++ +V + S++ ++ Sbjct: 1233 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1286 Query: 577 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 636 LR H L L + +E +R+ +E+ + +E L L Sbjct: 1287 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343 Query: 637 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 696 + + +A R L Q + + + +RS+ ++ QL ++ Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1398 Query: 697 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 756 E KA AE E +++ + I+ + L+ + +GG E Sbjct: 1399 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1440 Query: 757 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 811 AL R + E ++ +++RR++ A + +V ++ + + Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500 Query: 812 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 866 + L + + + A +L E + ALE A ++ +S + Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 E Q ++ ++ + + A + + +AER + EL L+A E L L+L+ Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1615 Query: 927 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 976 E K L ++ K +E +E R E++ + A++ +EK Q Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675 Query: 977 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1034 RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E + Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1730 Query: 1035 GIATLVSGIAGGAIPGQAPGSVPGPGL---------VKDSPLLLQQISAMRLHISQLQHE 1085 + L++ A ++ L + + L+ ++ QL E Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790 Query: 1086 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1143 ++ + A+ + LA KL+ G + L A ++ E L +L+ Sbjct: 1791 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 1842 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1189 R A A + E++AQL+ SD+ + + ++++T+ QR Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 91.3 bits (225), Expect = 5e-18 Identities = 191/864 (22%), Positives = 356/864 (41%), Gaps = 137/864 (15%) Query: 196 EEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 E E Q + LEE+L L+ + A K +ELE +L +V+ + +A + Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEA---ELAKVRAEMEVLLASKARAEEE 1914 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAI----EMATLDKEMAEERAESLQQEVE-ALKE 310 + +++K+ LEA+ E+A+ A + E A +++AEE A + E E L E Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 Query: 311 RV------DELTTDLEIL----KAEIEEKGSDGAASSYQLKQLEEQNAR----LKDALVR 356 ++ L T+ EI +AE E ++Q ++LEEQ A+ +++ L + Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 Query: 357 MRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA 416 +R S SE +E++ +E +QR +++EE+ +++ ++ AA G Sbjct: 2035 LRKASDSE----------LERQKGLVEDTLRQRRQVEEEILALKASFEK------AAAGK 2078 Query: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476 E+ L N E+ +R + +LEA + +E R E E R Q +A Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQA--ELEAARQRQLAAEEERRRREAEERVQKSLAAEE- 2135 Query: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHL-QDVNRELTNQQEASVERQQQPPPETFDF 535 EA ++ +AA E V + +++ R+L Q+ R+L QEA+ +R Q Sbjct: 2136 -EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ--------- 2185 Query: 536 KIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRL 595 AE KAHA A++ + ++++ + S+L G+ + R Sbjct: 2186 ----AEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLR--------GEAEAAR------RA 2226 Query: 596 ICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHAL 654 +AE R QA+ E + E L+ +A EQ A + L+ + Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286 Query: 655 SQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLT-KAIKYYQHLYSI 713 +Q ++ + EM H++ + + K Q+++ + L + + ++L Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLR--QKAQVEQELTTLRLQLEETDHQKNLLDE 2344 Query: 714 HLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSD 773 L + T + A + L + V++ L L+ EA + AL+LRD + + Sbjct: 2345 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSK-LKARIEAENRALILRDKDNTQRF 2402 Query: 774 IRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIA 833 +++ +K++ QV++ A VAA A + Sbjct: 2403 LQEEAEKMK-------------------QVAEE------------AARLSVAAQEAARLR 2431 Query: 834 PLAENEGLLVAALEELAFKASEQIY--GTPSSSPYECLRQSCNILISTMNKLATAMQEGE 891 LAE + AL E K Q T + E L+Q + + A +QE Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQE-- 2485 Query: 892 YDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE-DRETVIKELKKSLKIKGEELSEAN 950 D E+ A AE T L+ E R+ + + LK++ E+S A Sbjct: 2486 -DKEQ-----------MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKE---KEFEETMDALQADIDQLE 1007 R ++ A++ E++ + + +E L++ E ++ + + L+ I +LE Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593 Query: 1008 AEKAELKQ-----RLNSQSKRTIE 1026 EK +L+Q +L S+ +T++ Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ 2617 Score = 86.7 bits (213), Expect = 1e-16 Identities = 210/948 (22%), Positives = 385/948 (40%), Gaps = 163/948 (17%) Query: 195 KEEEGLRAQVR-DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253 +EE RAQ + + E E + + K E + ++Q E+V + KS Q A+ + Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ---AEAE 1800 Query: 254 RRLKEARKEAKEALEAKERYM----------------------------EEMADTADAIE 285 ++ +EA +EA+ +A+E+ + +E+ E Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860 Query: 286 MATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEI-----------EEKGSDGA 334 +++ EE LQ+E A ++ EL +L ++AE+ EE S Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920 Query: 335 ASSYQL-------KQLEEQNARLK---DALVRMRDLSSSE------KQEHVKLQKL---- 374 S +L ++L E+ ARL+ + R R L+ + + E V +KL Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980 Query: 375 ------------MEKKNQELEVVRQ-------QRERLQEELSQAESTIDELKEQVDAALG 415 +++K E E +R+ QR RL+E+ +Q ++ I+E Q+ A Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 Query: 416 AE-----EMVEMLTDRNLNLEEKVRELRET-----VGDLEAMNEMNDELQENARET---- 461 +E +VE + +EE++ L+ + G E E+ ++ NA +T Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG-RIRSNAEDTLRSK 2099 Query: 462 ---ELELREQLDMAG---ARVREAQKRVE----AAQETVADYQQTIKKYRQLTAHLQDVN 511 ELE Q +A R REA++RV+ A +E + +++ +L A +++ Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA- 2158 Query: 512 RELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAF 571 R L + E RQ Q E +++ AE KAHA A++ + ++++ + S+L Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ-QTLQQEQSVLDQL 2216 Query: 572 MPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQ-EKFELSENCSERPGLRGAAGEQL 630 G+ + R +AE R QA+ E + E L+ +A EQ Sbjct: 2217 R--------GEAEAA------RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262 Query: 631 SFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQ 690 A + L+ + +Q ++ + EM H++ + L K Q Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQ 2320 Query: 691 LDETVNVEPL-TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRA 749 +++ + L + + ++L L + T + A + L + V++ L + Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEEL-S 2378 Query: 750 FLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTL-L 808 L+ EA + AL+LRD + + +++ +K+++ +A + A ++ Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ--VAEEAARLSVAAQEAARLRQLAEE 2436 Query: 809 DCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYEC 868 D + +L+E A + AE E L+ +ELA + + ++ + Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAE--LLQQQKELAQEQARRLQEDKEQMAQQ- 2493 Query: 869 LRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAE------ITDAEGLG 922 L + T+ A ++ E AE K E+ A RAE AE +G Sbjct: 2494 LAEETQGFQRTLE--AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551 Query: 923 LKLEDRETVIKE---LKKSLKIK-------GEELSEANVRLSLLEKKLDSAAKDADERIE 972 KL E +E L ++L+I+ E L EA L ++KL AK + E Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611 Query: 973 KVQT-----RLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQ 1015 ++QT L+ETQAL ++ F D+L +E EKA+L+Q Sbjct: 2612 EMQTVQQEQLLQETQAL----QQSFLSEKDSLLQRERFIEQEKAKLEQ 2655 Score = 85.1 bits (209), Expect = 4e-16 Identities = 125/532 (23%), Positives = 230/532 (43%), Gaps = 50/532 (9%) Query: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEK-HKIQLEQV-QEWKSKMQEQQA- 250 +K EE R + R +E L+L + + +L+ EK H ++Q QE + +Q++Q+ Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2212 Query: 251 --DLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEAL 308 L+ + AR+ A+EA EA+ + E A + +E A K+ AEE+A++ Q A Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272 Query: 309 ----KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE---QNARLKDALVRMR-DL 360 KE E + +A + +K + A K E+ Q A+++ L +R L Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332 Query: 361 SSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMV 420 ++ Q+++ ++L K + E R QR +++EEL ++EL ++ A + AE Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAAR-QRSQVEEELFSVRVQMEEL-SKLKARIEAENRA 2390 Query: 421 EMLTDRNLN---LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVR 477 +L D++ L+E+ ++++ + ++ E + E +L +Q +A ++ Sbjct: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450 Query: 478 EAQKRVEAAQETVAD---YQQTIKKYRQLTAHLQDVNRELTNQ-----------QEASVE 523 E + V+ A A+ QQ + ++ LQ+ ++ Q EA + Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510 Query: 524 RQQQPPPETFDFKIKFAE-TKAHAKAIEMELR---QMEVAQANRHMSLL------TAFMP 573 RQ + E K++ AE ++A A+A E R Q E H + L T Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQA---QEKFELSENCSERPGLRGAAGEQL 630 R DHD + + L + E ++++A Q K E + + L+ Q Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630 Query: 631 SFAAGLVYSLSLLQAT--LHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLD 680 SF L SLLQ + + + L Q D K L E ++ ++ Sbjct: 2631 SF---LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Score = 84.7 bits (208), Expect = 5e-16 Identities = 80/331 (24%), Positives = 156/331 (47%), Gaps = 23/331 (6%) Query: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLK-ELEKHKIQLEQVQEWKSKMQEQQADLQRR 255 EE L AQ R L EK+ +++ ++ +LK E E + Q E QE ++QE + + ++ Sbjct: 2435 EEDL-AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 L E + + LEA+ + EM+ A+ +++ + A+ RAE ++ + +++ +E+ Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE---EDAQRFRKQAEEI 2550 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLM 375 L + +EK + Q +Q + RL++A+ + EK++ + KL+ Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL 2606 Query: 376 EKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVR 435 + K++E++ V QQ + LQE + +S + E D+ L E +E LE+ Sbjct: 2607 QLKSEEMQTV-QQEQLLQETQALQQSFLSE----KDSLLQRERFIE---QEKAKLEQL-- 2656 Query: 436 ELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQ 495 ++ V + + E Q+ + L ++ A R EA++ V QE + QQ Sbjct: 2657 -FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE---ELQQ 2712 Query: 496 TIKKYRQLTAHLQDVNRELTNQQEASVERQQ 526 ++ RQ L + N+ L Q + E+ + Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743 Score = 84.0 bits (206), Expect = 8e-16 Identities = 173/855 (20%), Positives = 328/855 (38%), Gaps = 108/855 (12%) Query: 200 LRAQVRDLEEKLETLRLKRAEDKAKLKEL----EKHKIQLEQVQEWKSKMQEQQADLQRR 255 + ++R + +LE +R + +L+ L E+ + Q Q QE +++ Q D +R Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646 Query: 256 LKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDEL 315 ++A E ++A+ E A+E L E AE R Q EVE ++ L Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1704 Query: 316 TTDLEILKAEIEEKGSDGAASSYQLKQ-LEEQNARLKDALVRMRDLSSSEKQEHVKLQKL 374 T +AE++ K + A + QL++ L+E++ A+ ++R+ + Q+ + ++ Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV----AVAQLREEAERRAQQQAEAERA 1760 Query: 375 MEKKNQELEV----------VRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLT 424 E+ +ELE +R Q E + ++ S A++ ++ KE+ + E Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820 Query: 425 DRNLNLEEKVRELRETVGDLEAMNEM--NDELQENARETEL--ELREQLDMAGARV-REA 479 R L E+ E + + + A + EL ETE + R+ L+ AR+ REA Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880 Query: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKF 539 + QE A+ + + L A E + E S +R + E F+ + Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA---EAGRFR-EL 1936 Query: 540 AETKAHAKAIEMEL-RQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICK 598 AE A +A+ E RQ ++A+ + R + + VL +L Sbjct: 1937 AEEAARLRALAEEAKRQRQLAE-------------EDAARQRAEAERVLA----EKLAAI 1979 Query: 599 AELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCS 658 E R + + + L E +E LR A ++ R E +Q Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAF--------------QRRRLEEQAAQHK 2025 Query: 659 VDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQ 718 D+ +++ L + L+E D L + VE A+K + AE Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVE----DTLRQRRQVEEEILALKASFEKAAAGKAE- 2080 Query: 719 PEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFC 778 + +E+GR+R+ A D E + RQ Sbjct: 2081 ---------------------LELELGRIRS------NAEDTLRSKEQAELEAARQRQLA 2113 Query: 779 KKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAEN 838 + RR + + +LA + + + + + A ++E A+ + AE Sbjct: 2114 AEEERRRREAEER-VQKSLAAEEEAARQRKAALEEVERLKAKVEE-----ARRLRERAEQ 2167 Query: 839 EGLLVAALEELA----FKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDA 894 E L + A +A E+ + + L+Q+ S +++L + A Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227 Query: 895 ERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLS 954 E E AA R ++ +AE L E++ + + + + +E + R + Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287 Query: 955 LLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELK 1014 E+ + AD +EK + E+T LR+K + E+ + L+ +++ + +K L Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT---LRQK-AQVEQELTTLRLQLEETDHQKNLLD 2343 Query: 1015 QRLNSQSKRTIEGLR 1029 + L E R Sbjct: 2344 EELQRLKAEATEAAR 2358 Score = 82.4 bits (202), Expect = 2e-15 Identities = 190/857 (22%), Positives = 340/857 (39%), Gaps = 134/857 (15%) Query: 201 RAQVRDLEEKLETLR-LKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEA 259 R ++ ++E LE R L A +AK + + K +++QE + +E D Q++ + Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555 Query: 260 RKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDL 319 ++E ++ ++ E ++ A A+A E + L EE ++ ++EA + + +L Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRL---RIEEEIRVVRLQLEATERQRGGAEGEL 1612 Query: 320 EILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKL-------- 371 + L+A EE + Q +Q +E+ RL+ +++D S ++Q V+L Sbjct: 1613 QALRARAEE-------AEAQKRQAQEEAERLRR---QVQDESQRKRQAEVELASRVKAEA 1662 Query: 372 QKLMEKKN--QELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLN 429 + EK+ Q LE +R Q E + L QAE E QV AL + Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEV---ERARQVQVALETAQ-----RSAEAE 1714 Query: 430 LEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQET 489 L+ K E LE LQE +LRE+ + + EA++ E A+ Sbjct: 1715 LQSKRASFAEKTAQLER------SLQEE-HVAVAQLREEAERRAQQQAEAERAREEAERE 1767 Query: 490 VADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAI 549 + +Q + +L ++V ++ + Q A E+Q++ E + KA Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAER---------EARRRGKAE 1817 Query: 550 EMELRQMEVA----QANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQ 605 E +RQ E+A + R ++ TA RL + ELIR + Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTA---------------------QQRLAAEQELIRLR 1856 Query: 606 AQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKV 665 A E + +R L AA L+A L + ++ V + K Sbjct: 1857 A----ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVR---AEMEVLLASKA 1909 Query: 666 GSLYPEMSAHERSLDFLIELL--HKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCT 723 + S E+S L ++ +E + L + K + L A Q + Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969 Query: 724 MQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKK--- 780 LA+ +L A + + T+ + L++ E +R+ + Sbjct: 1970 RVLAE-----------------KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012 Query: 781 IRRRMPGTDA---PGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAE 837 RRR+ A I LA + SD+ L+ +K L V L++ +++A A Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKAS 2070 Query: 838 NEGLLVAALEELAFKASEQIYGTPSSSPYECLR--QSCNILISTMNKLATAMQEGEYDAE 895 E E E G S+ + LR + + + +LA + +AE Sbjct: 2071 FEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124 Query: 896 RPPSKPPPVELRAAALR-AEITDAEGLGLKLED----RETVIKELKKSLKIKGEELSEAN 950 K E AA R A + + E L K+E+ RE +E + L++ E A Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQ 2181 Query: 951 VRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEK 1010 RL EK + A ++ +++Q L++ Q++L + E E A + EAE+ Sbjct: 2182 KRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE------EAEE 2232 Query: 1011 AELK-QRLNSQSKRTIE 1026 A ++ +R +QS+R +E Sbjct: 2233 ARVQAEREAAQSRRQVE 2249 Score = 68.2 bits (165), Expect = 5e-11 Identities = 184/934 (19%), Positives = 352/934 (37%), Gaps = 120/934 (12%) Query: 190 LPSPSKEEEGLRA----------QVRDLE----EKLETLRLKRAEDKAKLKELEKHKIQL 235 LP PS LR+ QVR L EKL+T+ L + + L H+ QL Sbjct: 1190 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249 Query: 236 EQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAE 295 ++ Q + + E +A + LK+ R +A+ + +E+ + E + Sbjct: 1250 KEAQAVPATLPELEA-TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308 Query: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALV 355 E ++ V L ER + ++ + E+E+ G Y + + A L+DA Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ---LRYYRESADPLGAWLQDARR 1365 Query: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE------- 408 R + + + +++ + ++ LE + + E+++E A+ I+ +K+ Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425 Query: 409 -------------QVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQ 455 + G+E +++ D + E + + + +E + Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485 Query: 456 ENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELT 515 A + E RE+L A + + ++ EA + A ++ K+ + Q + E+ Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ------QRMQEEVV 1539 Query: 516 NQQEASVERQQQPP--PETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMP 573 ++EA+V+ QQQ E + +E + AKA + E + + + ++ + Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599 Query: 574 DSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLR---------- 623 + + GG + L +AE ++QAQE+ E + R Sbjct: 1600 ATERQRGGAEGELQALRARAE---EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1656 Query: 624 --GAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDF 681 A E + +L L+ E L Q V+ ++V + +RS + Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV---QVALETAQRSAEA 1713 Query: 682 LIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSA---LD 738 ++ ++T +E + +H+ L E+ E Q A+ + + A L+ Sbjct: 1714 ELQSKRASFAEKTAQLERSLQE----EHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769 Query: 739 CMSVEVGR-LRAFLQGGQEATDIALLLRDLETSCSD---------------------IRQ 776 ++ LR LQ + A +L + E + Q Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829 Query: 777 FCKKIRRRMPGTDAPGIPAALAFGPQVSDTLL--DCRKHLTWVVAVLQEVAAAAAQ---- 830 +K R+ GT + A ++T R+ L +A LQ AAAA Q Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889 Query: 831 LIAPLAENEGLLVAALEELAFKASEQIYGTPSSSP---------YECLRQSCNILISTMN 881 L A LA+ + L A +A E+ T S + L + L + Sbjct: 1890 LEAELAKVRAEMEVLLASKA-RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948 Query: 882 KLATAMQEGEYDAERPPSKPPPVELRAAALRAEI----TDAEGLGLKLEDRETV-IKELK 936 + Q E DA R ++ V A E T+AE + LK ++ E ++ L Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLA 2007 Query: 937 KSLKIKGEELSE-ANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEET 995 + + L E A + +E++L K +D +E+ + +E+T ++ ++ EE Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT----LRQRRQVEEE 2063 Query: 996 MDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029 + AL+A ++ A KAEL+ L + LR Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097 Score = 66.2 bits (160), Expect = 2e-10 Identities = 82/347 (23%), Positives = 159/347 (45%), Gaps = 36/347 (10%) Query: 195 KEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR 254 ++ + R Q ++ EKL L E ++ LE IQ +Q +++E A+L+R Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELER 2594 Query: 255 RLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE 314 ++ ++EAK L+ K EM T+ +E + ++LQQ + K+ + + Sbjct: 2595 EKEKLQQEAK-LLQLKSE------------EMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641 Query: 315 LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE---KQEHVKL 371 +E KA++E+ D A + QL++ E+Q + + R R ++S E +++H + Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASMEEARRRQH-EA 2699 Query: 372 QKLMEKKNQELEVVRQQR----ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRN 427 ++ + +K +EL+ + QQR E L EE + + L+EQ AAL E V T Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV---TASQ 2756 Query: 428 LNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQ 487 + + + R+ + A E R+ ++L AG E +R+ Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGILSAEELQRLAQGH 2813 Query: 488 ETVADY--QQTIKKYRQLTAHLQDVNRELTNQQ---EASVERQQQPP 529 TV + ++ ++ Y Q + + + + TN++ A+++RQ P Sbjct: 2814 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSP 2860 Score = 60.1 bits (144), Expect = 1e-08 Identities = 198/1006 (19%), Positives = 392/1006 (38%), Gaps = 121/1006 (12%) Query: 247 EQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMAT-LDKEMAEERAESL---- 301 EQ A + R + E K+ R E +T + LDKE A E A+ + Sbjct: 1110 EQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ 1164 Query: 302 --QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY------QLKQLEEQNA----R 349 Q EVE L + V L+ + E + A E + S +L+Q+ +A + Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224 Query: 350 LKDALVRMRDLSSSEK-----QEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404 LK + +R +E+ +E +K + + ELE + ++L+ + + T D Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284 Query: 405 ELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDL----EAMNEMNDELQENARE 460 L++++ GA+E+ E L R+ + +V RE V L +A+ D Q + Sbjct: 1285 ALRDEL---RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341 Query: 461 TELEL---REQLDMAGARVREAQKRVEAAQE-TVADYQQTIKKYRQLTAHLQDVNRELTN 516 +L RE D GA +++A++R E Q +AD Q ++ RQ A L+++ R Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401 Query: 517 QQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSF 576 +E +Q D++++ KA + + ++ +V + S++ ++ Sbjct: 1402 VEECQ-RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVD--- 1455 Query: 577 LRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGL 636 LR H L L + +E +R+ +E+ + +E L L Sbjct: 1456 LR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512 Query: 637 VYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVN 696 + + +A R L Q + + + +RS+ ++ QL ++ Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ-----QLRQSSE 1567 Query: 697 VEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQE 756 E KA AE E +++ + I+ + L+ + +GG E Sbjct: 1568 AEIQAKA----------RQAEAAERSRLRIEEEIRVVRLQLEATERQ--------RGGAE 1609 Query: 757 ATDIALLLR--DLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQV---SDTLLDCR 811 AL R + E ++ +++RR++ A + +V ++ + + Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669 Query: 812 KHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSS-----SPY 866 + L + + + A +L E + ALE A ++ +S + Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729 Query: 867 ECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926 E Q ++ ++ + + A + + +AER + EL L+A E L L+L+ Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER-ELERWQLKAN----EALRLRLQ 1784 Query: 927 DRETV-IKELKKSLKIKGEELSEANV-RLSLLEKKLDSAAKDADERIEK--------VQT 976 E K L ++ K +E +E R E++ + A++ +EK Q Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844 Query: 977 RLEETQAL--LRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPS 1034 RL Q L LR + ++ E+ L+ ++ +L+ E A +Q ++ +E + Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-----TQKRQELEAELAKVRA 1899 Query: 1035 GIATLVSGIAGGAIPGQAPGSVPGPGL---------VKDSPLLLQQISAMRLHISQLQHE 1085 + L++ A ++ L + + L+ ++ QL E Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959 Query: 1086 NSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGA--LYRKTSQLLETLNQLSTHTHV 1143 ++ + A+ + LA KL+ G + L A ++ E L +L+ Sbjct: 1960 DAARQRAEAERVLAE-------KLAAIGEATRLKTEAEIALKEKEAENERLRRLA-EDEA 2011 Query: 1144 VDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQR 1189 R A A + E++AQL+ SD+ + + ++++T+ QR Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.311 0.127 0.343 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 46,543,305 Number of Sequences: 37866 Number of extensions: 2282788 Number of successful extensions: 38403 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 675 Number of HSP's successfully gapped in prelim test: 1696 Number of HSP's that attempted gapping in prelim test: 14538 Number of HSP's gapped (non-prelim): 13656 length of query: 1253 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1139 effective length of database: 13,930,794 effective search space: 15867174366 effective search space used: 15867174366 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.