Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 19923570
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
(733 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1475 0.0
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1417 0.0
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1194 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1163 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1163 0.0
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1108 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 558 e-159
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 535 e-152
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 534 e-151
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 433 e-121
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 375 e-104
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 367 e-101
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 289 6e-78
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 289 6e-78
gi|4502023 AKT2 kinase [Homo sapiens] 285 8e-77
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 283 3e-76
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 283 3e-76
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 283 3e-76
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 283 3e-76
gi|62241015 AKT1 kinase [Homo sapiens] 280 3e-75
gi|62241013 AKT1 kinase [Homo sapiens] 280 3e-75
gi|62241011 AKT1 kinase [Homo sapiens] 280 3e-75
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 278 2e-74
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 278 2e-74
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 265 9e-71
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 265 9e-71
gi|5453974 protein kinase N2 [Homo sapiens] 263 3e-70
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 261 2e-69
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 257 2e-68
gi|28557781 protein kinase C, eta [Homo sapiens] 257 3e-68
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1475 bits (3818), Expect = 0.0
Identities = 733/733 (100%), Positives = 733/733 (100%)
Query: 1 MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE 60
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
Sbjct: 1 MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE 60
Query: 61 LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF 120
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
Sbjct: 61 LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF 120
Query: 121 IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI 180
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
Sbjct: 121 IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI 180
Query: 181 IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA 240
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
Sbjct: 181 IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA 240
Query: 241 DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN 300
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
Sbjct: 241 DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN 300
Query: 301 RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS 360
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
Sbjct: 301 RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS 360
Query: 361 PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED 420
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
Sbjct: 361 PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED 420
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 480
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
Sbjct: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK 480
Query: 481 FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY 540
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
Sbjct: 481 FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY 540
Query: 541 RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL 600
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
Sbjct: 541 RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL 600
Query: 601 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR 660
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
Sbjct: 601 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR 660
Query: 661 LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA 720
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
Sbjct: 661 LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA 720
Query: 721 QRRGMKRLTSTRL 733
QRRGMKRLTSTRL
Sbjct: 721 QRRGMKRLTSTRL 733
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1417 bits (3667), Expect = 0.0
Identities = 701/701 (100%), Positives = 701/701 (100%)
Query: 33 EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV 92
EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV
Sbjct: 41 EEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV 100
Query: 93 LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152
LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK
Sbjct: 101 LKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 160
Query: 153 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 212
EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH
Sbjct: 161 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 220
Query: 213 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 272
DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL
Sbjct: 221 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 280
Query: 273 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 332
KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK
Sbjct: 281 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 340
Query: 333 PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL 392
PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL
Sbjct: 341 PPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL 400
Query: 393 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD 452
HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD
Sbjct: 401 HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRD 460
Query: 453 PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV 512
PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV
Sbjct: 461 PSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDV 520
Query: 513 LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC 572
LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC
Sbjct: 521 LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPC 580
Query: 573 YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA 632
YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA
Sbjct: 581 YTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA 640
Query: 633 LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK 692
LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK
Sbjct: 641 LSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVK 700
Query: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL
Sbjct: 701 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 741
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1194 bits (3088), Expect = 0.0
Identities = 589/701 (84%), Positives = 642/701 (91%), Gaps = 4/701 (0%)
Query: 34 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 93
EE +KEI I+HHVKEG EKADPSQFELLKVLGQGS+GKVFLV+K+ GSDA QLYAMKVL
Sbjct: 43 EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL 102
Query: 94 KKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 153
KKATLKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE
Sbjct: 103 KKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 162
Query: 154 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 213
VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKE+IDH+
Sbjct: 163 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHE 222
Query: 214 KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILK 273
K+AYSFCGT+EYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG+LPFQGKDRKETM +ILK
Sbjct: 223 KKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILK 282
Query: 274 AKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKP 333
AKLGMPQFLS EAQSLLR LFKRNP NRLGAG DGVEEIKRH FF TIDWN LYR+EI P
Sbjct: 283 AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHP 342
Query: 334 PFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLH 393
PFKPA GRPEDTF+FDPEFTA+TP DSPG+PPSANAH LFRGFSFVA + + Q +
Sbjct: 343 PFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQ 400
Query: 394 KVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDP 453
V VH IVQQLH N+I FTDGYE+KEDIGVGSYSVCKRC+HKAT+ E+AVKIIDKSKRDP
Sbjct: 401 TVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDP 460
Query: 454 SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVL 513
+EEIEILLRYGQHPNIITLKDVYDDGK+VY+V ELM+GGELLD+ILRQ++FSEREAS VL
Sbjct: 461 TEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVL 520
Query: 514 CTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY 573
TITKT++YLH+QGVVHRDLKPSNILY DESG+PESIR+CDFGFAKQLRA NGLLMTPCY
Sbjct: 521 FTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY 580
Query: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
TANFVAPEVLKRQGYDAACDIWSLG+LLYTML G+TPFANGPDDTPEEILARIGSGK++L
Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640
Query: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVK 692
SGG W+S+SD AKD+VSKMLHVDPHQRLTA VL+HPW+V+ + L QL+RQD HLVK
Sbjct: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVK 700
Query: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
GAMAATY ALNR Q+P LEPV S LAQRRG+K++TST L
Sbjct: 701 GAMAATYSALNRN-QSPVLEPVGRSTLAQRRGIKKITSTAL 740
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1163 bits (3008), Expect = 0.0
Identities = 574/728 (78%), Positives = 639/728 (87%), Gaps = 12/728 (1%)
Query: 17 YLRRKSRSKSSSLS-----------RLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVL 65
+L RK R + S S R +EGV+KEI I+HHVK G EKADPS FELLKVL
Sbjct: 18 WLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHFELLKVL 77
Query: 66 GQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLH 125
GQGS+GKVFLVRKV D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VNHPF+VKLH
Sbjct: 78 GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 137
Query: 126 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 185
YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHSLGIIYRDL
Sbjct: 138 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 197
Query: 186 KPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSF 245
KPENILLDEEGHIK+TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+ SADWWS+
Sbjct: 198 KPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 257
Query: 246 GVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAG 305
GVLMFEMLTGSLPFQGKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRNP NRLG+G
Sbjct: 258 GVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSG 317
Query: 306 IDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP 365
DG EEIKRH F+ TIDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP DSPG+PP
Sbjct: 318 PDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPP 377
Query: 366 SANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGS 425
SA AH LFRGFSFVA+ L+++ + + P+H +VQQLHG N+ F+DGY +KE IGVGS
Sbjct: 378 SAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGS 437
Query: 426 YSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
YS CKRCVHKAT+ EYAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK VYLV
Sbjct: 438 YSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLV 497
Query: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
ELMRGGELLD+ILRQ++FSEREAS VL TI KT++YLHSQGVVHRDLKPSNILY DESG
Sbjct: 498 TELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESG 557
Query: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
+PE +R+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSLGILLYTML
Sbjct: 558 NPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTML 617
Query: 606 AGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQ 665
AG+TPFANGP DTPEEIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDPHQRLTA Q
Sbjct: 618 AGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQ 677
Query: 666 VLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGM 725
VL+HPWV ++ L +QLS QD+ LVKGAMAATY ALN + P+L+P+ SS LAQRR +
Sbjct: 678 VLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRR-V 736
Query: 726 KRLTSTRL 733
++L ST L
Sbjct: 737 RKLPSTTL 744
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1163 bits (3008), Expect = 0.0
Identities = 568/713 (79%), Positives = 636/713 (89%), Gaps = 1/713 (0%)
Query: 21 KSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVK 80
++ + + L ++EGV+KEI I+HHVK G EKADPS FELLKVLGQGS+GKVFLVRKV
Sbjct: 24 QTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVT 83
Query: 81 GSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDF 140
D+G LYAMKVLKKATLKVRDRVR+KMERDILA+VNHPF+VKLHYAFQTEGKLYLILDF
Sbjct: 84 RPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDF 143
Query: 141 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKI 200
LRGGDLFTRLSKEVMFTEEDVKFYLAELAL LDHLHSLGIIYRDLKPENILLDEEGHIK+
Sbjct: 144 LRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKL 203
Query: 201 TDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQ 260
TDFGLSKEAIDH+K+AYSFCGT+EYMAPEVVNR+GH+ SADWWS+GVLMFEMLTGSLPFQ
Sbjct: 204 TDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQ 263
Query: 261 GKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVT 320
GKDRKETM LILKAKLGMPQFLS EAQSLLRALFKRNP NRLG+G DG EEIKRH F+ T
Sbjct: 264 GKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYST 323
Query: 321 IDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVA 380
IDWN LYR+EIKPPFKPAV +P+DTF+FD EFT+RTP DSPG+PPSA AH LFRGFSFVA
Sbjct: 324 IDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVA 383
Query: 381 SSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTE 440
+ L+++ + + P+H +VQQLHG N+ F+DGY +KE IGVGSYS CKRCVHKAT+ E
Sbjct: 384 TGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNME 443
Query: 441 YAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILR 500
YAVK+IDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK VYLV ELMRGGELLD+ILR
Sbjct: 444 YAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR 503
Query: 501 QRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQ 560
Q++FSEREAS VL TI KT++YLHSQGVVHRDLKPSNILY DESG+PE +R+CDFGFAKQ
Sbjct: 504 QKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQ 563
Query: 561 LRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPE 620
LRA NGLLMTPCYTANFVAPEVLKRQGYD CDIWSLGILLYTMLAG+TPFANGP DTPE
Sbjct: 564 LRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE 623
Query: 621 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSP 680
EIL RIGSGK+ LSGGNW+++S+ AKD+VSKMLHVDPHQRLTA QVL+HPWV ++ L
Sbjct: 624 EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQ 683
Query: 681 NQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
+QLS QD+ LVKGAMAATY ALN + P+L+P+ SS LAQRR +++L ST L
Sbjct: 684 SQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRR-VRKLPSTTL 735
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1108 bits (2865), Expect = 0.0
Identities = 541/701 (77%), Positives = 618/701 (88%), Gaps = 4/701 (0%)
Query: 34 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 93
+EGVVKEI I+HHVKEG+EKADP+QFELLKVLGQGS+GKVFLVRK G DAGQLYAMKVL
Sbjct: 48 DEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL 107
Query: 94 KKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 153
KKA+LKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGD+FTRLSKE
Sbjct: 108 KKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE 167
Query: 154 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 213
V+FTEEDVKFYLAELALALDHLH LGI+YRDLKPENILLDE GHIK+TDFGLSKE++D +
Sbjct: 168 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 227
Query: 214 KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILK 273
K+AYSFCGT+EYMAPEVVNRRGH+QSADWWS+GVLMFEMLTG+LPFQGKDR ETM +ILK
Sbjct: 228 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILK 287
Query: 274 AKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKP 333
AKLGMPQFLS EAQSLLR LFKRNP NRLG+ +GVEEIKRH FF IDW+ LY++E++P
Sbjct: 288 AKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQP 345
Query: 334 PFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLH 393
PFKPA G+P+DTF FDPEFTA+TP DSPG+P SANAH LF+GFSFVA+S+ +E +
Sbjct: 346 PFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPIT 405
Query: 394 KVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDP 453
V PIV Q++GN F + YE+KEDIGVGSYSVCKRC+H T+ E+AVKIIDKSKRDP
Sbjct: 406 SANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDP 464
Query: 454 SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVL 513
SEEIEIL+RYGQHPNIITLKDV+DDG++VYLV +LM+GGELLDRIL+Q+ FSEREASD+L
Sbjct: 465 SEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDIL 524
Query: 514 CTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY 573
I+KT+DYLH QGVVHRDLKPSNILY DES S +SIR+CDFGFAKQLR NGLL+TPCY
Sbjct: 525 YVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY 584
Query: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
TANFVAPEVL +QGYDAACDIWSLG+L YTMLAG+TPFANGP+DTPEEIL RIG+GK++L
Sbjct: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
Query: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVK 692
SGGNWD+ISD AKD++S MLH+DPHQR TA Q+LKH W+ +R+ L +Q R DV H+VK
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVK 704
Query: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
GAM ATY AL P LEPV +S+LAQRR MK+ TST L
Sbjct: 705 GAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL 745
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 558 bits (1438), Expect = e-159
Identities = 312/713 (43%), Positives = 446/713 (62%), Gaps = 36/713 (5%)
Query: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 109
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 110 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 168
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 169 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 227
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 228 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 282 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 342 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 401
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
Query: 402 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 448
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
Query: 449 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 508
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
Query: 509 ASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLL 568
AS ++ + + ++H GVVHRDLKP N+L+ DE+ + E I++ DFGFA+ N L
Sbjct: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPL 579
Query: 569 MTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDD----TPEEILA 624
TPC+T ++ APE+L + GYD +CD+WSLG++LYTML+G PF + + EI+
Sbjct: 580 KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 639
Query: 625 RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLS 684
+I G ++ G W ++S AKD++ +L VDP++RL + + W+ + LS N L
Sbjct: 640 KIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 699
Query: 685 RQDVHLVKGA-----MAATYFALNR-TPQAPRLEPVLSSNLAQRRGMKRLTST 731
D+ GA + AT+ A N+ + L+ V + LA+RR MK+ TST
Sbjct: 700 TPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 535 bits (1377), Expect = e-152
Identities = 306/736 (41%), Positives = 443/736 (60%), Gaps = 39/736 (5%)
Query: 33 EEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 91
++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAMK
Sbjct: 6 DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMK 65
Query: 92 VLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148
VL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 66 VLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFT 125
Query: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208
L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSKE
Sbjct: 126 HLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
Query: 209 AIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKE 266
+ +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
Query: 267 TMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTID 322
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +D
Sbjct: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
Query: 323 WNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASS 382
W L ++I PF+P + D +F EFT P SP P +F+G+SFVA S
Sbjct: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPS 365
Query: 383 LIQEPSQQDLHKVPVHP----------IVQQLHGNNIHFTDGYEI---KEDIGVGSYSVC 429
++ + + + P + + + F YE+ + +G GS+SVC
Sbjct: 366 ILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVC 425
Query: 430 KRCVHKATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMEL 488
+RC + + E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+EL
Sbjct: 426 RRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL 485
Query: 489 MRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GS 546
+RGGELL+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G+
Sbjct: 486 LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGA 545
Query: 547 PESIRVCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
P +++ DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY ML
Sbjct: 546 P--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMML 603
Query: 606 AGFTPF----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL 661
+G PF G EI+ +I G+++L G W +S+ AK++V +L VDP +RL
Sbjct: 604 SGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
Query: 662 TAMQVLKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVL 715
+ W+ + S L DV V+ + AT+ A NR + L+ V
Sbjct: 664 KLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVE 723
Query: 716 SSNLAQRRGMKRLTST 731
++ LA+RR K ++T
Sbjct: 724 NAPLAKRRKQKLRSAT 739
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 534 bits (1375), Expect = e-151
Identities = 306/730 (41%), Positives = 440/730 (60%), Gaps = 33/730 (4%)
Query: 33 EEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 91
++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAMK
Sbjct: 6 DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMK 65
Query: 92 VLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148
VL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 66 VLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFT 125
Query: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208
L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSKE
Sbjct: 126 HLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
Query: 209 AIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKE 266
+ +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
Query: 267 TMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTID 322
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +D
Sbjct: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
Query: 323 WNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASS 382
W L ++I PF+P + D +F EFT P SP P +F+G+SFVA S
Sbjct: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPS 365
Query: 383 LIQEPSQQDLHKVPVHPIVQQLHGN----NIHFTDGYEI---KEDIGVGSYSVCKRCVHK 435
++ + + + P G YE+ + +G GS+SVC+RC +
Sbjct: 366 ILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQR 425
Query: 436 ATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494
+ E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+EL+RGGEL
Sbjct: 426 QSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGEL 485
Query: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GSPESIRV 552
L+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G+P +++
Sbjct: 486 LEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VKI 543
Query: 553 CDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF 611
DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY ML+G PF
Sbjct: 544 IDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPF 603
Query: 612 ----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVL 667
G EI+ +I G+++L G W +S+ AK++V +L VDP +RL +
Sbjct: 604 QGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR 663
Query: 668 KHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVLSSNLAQ 721
W+ + S L DV V+ + AT+ A NR + L+ V ++ LA+
Sbjct: 664 GSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAK 723
Query: 722 RRGMKRLTST 731
RR K ++T
Sbjct: 724 RRKQKLRSAT 733
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 433 bits (1113), Expect = e-121
Identities = 235/507 (46%), Positives = 326/507 (64%), Gaps = 24/507 (4%)
Query: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 109
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 110 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 168
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 169 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 227
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 228 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 282 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 342 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 401
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
Query: 402 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 448
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
Query: 449 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 508
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
Query: 509 ASDVLCTITKTMDYLHSQGVVHRDLKP 535
AS ++ + + ++H GVVHRDLKP
Sbjct: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKP 547
Score = 106 bits (265), Expect = 7e-23
Identities = 83/323 (25%), Positives = 161/323 (49%), Gaps = 30/323 (9%)
Query: 413 DGYEIKEDIGVGSYS---VCKRCVHKATDTEYAVKIIDKS----KRDPSE----EIEILL 461
+ +E+ + +G G+Y + ++ T YA+K++ K+ K +E E ++L
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 462 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 521
Q P ++TL + ++L+++ + GGEL + ++ F+E E + I ++
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Query: 522 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAP 580
+LH G+++RD+K NIL D +G + + DFG +K+ A + C T ++AP
Sbjct: 167 HLHKLGIIYRDIKLENILL-DSNG---HVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 581 EVLK--RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGN 637
++++ G+D A D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
Query: 638 WDSISDAAKDVVSKMLHVDPHQRL-----TAMQVLKHPWV--VNREYLSPNQLSRQDVHL 690
+S AKD++ ++L DP +RL A ++ +H + +N + L+ ++ +
Sbjct: 280 -QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
Query: 691 VKGAMAATYFALNRTPQAPRLEP 713
++ + + FA T P P
Sbjct: 339 IRDELDVSNFAEEFTEMDPTYSP 361
Score = 83.2 bits (204), Expect = 8e-16
Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 13/129 (10%)
Query: 63 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV---NHP 119
K LG+GS+ + RK + Q +A+K++ K R+ + +++I A HP
Sbjct: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
Query: 120 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 179
IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +G
Sbjct: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
Query: 180 IIYRDLKPE 188
+++RDLKPE
Sbjct: 540 VVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 375 bits (964), Expect = e-104
Identities = 184/347 (53%), Positives = 250/347 (72%), Gaps = 3/347 (0%)
Query: 47 VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRV 104
V G EK P FELL+VLG+G YGKVF VRKV G++ G+++AMKVLKKA + +D
Sbjct: 79 VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 138
Query: 105 RSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 164
+K ER+IL EV HPFIV L YAFQT GKLYLIL++L GG+LF +L +E +F E+ FY
Sbjct: 139 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 198
Query: 165 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE 224
LAE+++AL HLH GIIYRDLKPENI+L+ +GH+K+TDFGL KE+I ++FCGTIE
Sbjct: 199 LAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIE 258
Query: 225 YMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSG 284
YMAPE++ R GH ++ DWWS G LM++MLTG+ PF G++RK+T+ ILK KL +P +L+
Sbjct: 259 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ 318
Query: 285 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPED 344
EA+ LL+ L KRN +RLGAG E++ HPFF I+W L ++++PPFKP + ED
Sbjct: 319 EARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEED 378
Query: 345 TFHFDPEFTARTPTDSPGVPP-SANAHHLFRGFSFVASSLIQEPSQQ 390
FD +FT +TP DSP S +A+ +F GF++VA S+++ ++
Sbjct: 379 VSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEK 425
Score = 112 bits (280), Expect = 1e-24
Identities = 83/284 (29%), Positives = 138/284 (48%), Gaps = 30/284 (10%)
Query: 433 VHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 492
V A DT + K++R+ EE++ HP I+ L + G +YL++E + GG
Sbjct: 131 VRNAKDTAHT-----KAERNILEEVK-------HPFIVDLIYAFQTGGKLYLILEYLSGG 178
Query: 493 ELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRV 552
EL ++ R+ F E A L I+ + +LH +G+++RDLKP NI+ + +++
Sbjct: 179 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG----HVKL 234
Query: 553 CDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFA 612
DFG K+ + T C T ++APE+L R G++ A D WSLG L+Y ML G PF
Sbjct: 235 TDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFT 294
Query: 613 NGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL-----TAMQVL 667
+ ++ + +I K L ++ A+D++ K+L + RL A +V
Sbjct: 295 G---ENRKKTIDKILKCKLNLP----PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 347
Query: 668 KHPWV--VNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAP 709
HP+ +N E L ++ L++ + F T Q P
Sbjct: 348 AHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTP 391
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 367 bits (943), Expect = e-101
Identities = 182/357 (50%), Positives = 249/357 (69%), Gaps = 4/357 (1%)
Query: 32 LEEEGVVKEIDISH-HVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 90
LE G +E++++ V G E+ P FELL+VLG+G YGKVF VRKV+G++ G++YAM
Sbjct: 39 LEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAM 98
Query: 91 KVLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148
KVL+KA + +D ++ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT
Sbjct: 99 KVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFT 158
Query: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208
L +E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIK+TDFGL KE
Sbjct: 159 HLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE 218
Query: 209 AIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268
+I ++FCGTIEYMAPE++ R GH ++ DWWS G LM++MLTGS PF ++RK+TM
Sbjct: 219 SIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTM 278
Query: 269 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 328
I++ KL +P +L+ +A+ L++ KRNP R+G G +++RHPFF ++W+ L
Sbjct: 279 DKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLA 338
Query: 329 KEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLI 384
+ PPF+P + ED FD FT +TP DSP S +A+ F GF++VA S++
Sbjct: 339 WRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
Score = 128 bits (322), Expect = 2e-29
Identities = 90/273 (32%), Positives = 139/273 (50%), Gaps = 28/273 (10%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTE----YAVKIIDKSK--RDPSEEIEI-----LLRY 463
+E+ +G G Y + V K T YA+K++ K+K R+ + +L
Sbjct: 67 FELLRVLGKGGYGKVFQ-VRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILES 125
Query: 464 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 523
+HP I+ L + G +YL++E + GGEL + R+ F E A L IT + +L
Sbjct: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
Query: 524 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 583
HSQG+++RDLKP NI+ S I++ DFG K+ + T C T ++APE+L
Sbjct: 186 HSQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEIL 241
Query: 584 KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISD 643
R G++ A D WSLG L+Y ML G PF + ++ + +I GK AL ++
Sbjct: 242 VRSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTP 294
Query: 644 AAKDVVSKMLHVDPHQRL-----TAMQVLKHPW 671
A+D+V K L +P QR+ A V +HP+
Sbjct: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPF 327
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 289 bits (740), Expect = 6e-78
Identities = 148/343 (43%), Positives = 220/343 (64%), Gaps = 11/343 (3%)
Query: 20 RKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKV 79
R + S +S + + EE + + +HH ++ + F+ LK+LG+G++GKV LVR+
Sbjct: 116 RMNCSPTSQIDNIGEEEM--DASTTHHKRKTM-----NDFDYLKLLGKGTFGKVILVRE- 167
Query: 80 KGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLIL 138
+G+ YAMK+LKK + +D V + E +L HPF+ L Y+FQT+ +L ++
Sbjct: 168 --KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVM 225
Query: 139 DFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 198
+++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS I+YRDLK EN++LD++GHI
Sbjct: 226 EYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHI 285
Query: 199 KITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLP 258
KITDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+ G LP
Sbjct: 286 KITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 345
Query: 259 FQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF 318
F +D ++ LIL + P+ LS +A+SLL L ++P RLG G D +EI RH FF
Sbjct: 346 FYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF 405
Query: 319 VTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP 361
++W +Y K++ PPFKP V DT +FD EFTA+T T +P
Sbjct: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 112 bits (279), Expect = 2e-24
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 474
+G G++ KA+ YA+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 475 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 534
+ + VME + GGEL + R+R FSE I +DYLHS +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 535 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 594
N++ D+ G I++ DFG K+ + T C T ++APEVL+ Y A D
Sbjct: 274 LENLML-DKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 595 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 654
W LG+++Y M+ G PF N + E++ + K+ ++S AK ++S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 655 VDPHQRL-----TAMQVLKH 669
DP++RL A ++++H
Sbjct: 383 KDPNKRLGGGPDDAKEIMRH 402
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 289 bits (740), Expect = 6e-78
Identities = 148/343 (43%), Positives = 220/343 (64%), Gaps = 11/343 (3%)
Query: 20 RKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKV 79
R + S +S + + EE + + +HH ++ + F+ LK+LG+G++GKV LVR+
Sbjct: 116 RMNCSPTSQIDNIGEEEM--DASTTHHKRKTM-----NDFDYLKLLGKGTFGKVILVRE- 167
Query: 80 KGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLIL 138
+G+ YAMK+LKK + +D V + E +L HPF+ L Y+FQT+ +L ++
Sbjct: 168 --KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVM 225
Query: 139 DFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 198
+++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS I+YRDLK EN++LD++GHI
Sbjct: 226 EYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHI 285
Query: 199 KITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLP 258
KITDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+ G LP
Sbjct: 286 KITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLP 345
Query: 259 FQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF 318
F +D ++ LIL + P+ LS +A+SLL L ++P RLG G D +EI RH FF
Sbjct: 346 FYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF 405
Query: 319 VTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP 361
++W +Y K++ PPFKP V DT +FD EFTA+T T +P
Sbjct: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 112 bits (279), Expect = 2e-24
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 474
+G G++ KA+ YA+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 475 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 534
+ + VME + GGEL + R+R FSE I +DYLHS +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 535 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 594
N++ D+ G I++ DFG K+ + T C T ++APEVL+ Y A D
Sbjct: 274 LENLML-DKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 595 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 654
W LG+++Y M+ G PF N + E++ + K+ ++S AK ++S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 655 VDPHQRL-----TAMQVLKH 669
DP++RL A ++++H
Sbjct: 383 KDPNKRLGGGPDDAKEIMRH 402
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 285 bits (730), Expect = 8e-77
Identities = 141/329 (42%), Positives = 212/329 (64%), Gaps = 6/329 (1%)
Query: 34 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 93
+ +E++++ V + K + F+ LK+LG+G++GKV LVR+ G+ YAMK+L
Sbjct: 129 DSSTTEEMEVA--VSKARAKVTMNDFDYLKLLGKGTFGKVILVRE---KATGRYYAMKIL 183
Query: 94 KKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152
+K + +D V + E +L HPF+ L YAFQT +L ++++ GG+LF LS+
Sbjct: 184 RKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
Query: 153 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDH 212
E +FTEE +FY AE+ AL++LHS ++YRD+K EN++LD++GHIKITDFGL KE I
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
Query: 213 DKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 272
+FCGT EY+APEV+ + ++ DWW GV+M+EM+ G LPF +D + LIL
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
Query: 273 KAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIK 332
++ P+ LS EA+SLL L K++P RLG G +E+ H FF++I+W + +K++
Sbjct: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
Query: 333 PPFKPAVGRPEDTFHFDPEFTARTPTDSP 361
PPFKP V DT +FD EFTA++ T +P
Sbjct: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITP 452
Score = 113 bits (283), Expect = 5e-25
Identities = 79/260 (30%), Positives = 130/260 (50%), Gaps = 22/260 (8%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPNIITLKD 474
+G G++ KAT YA+KI+ K +E+ +L+ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 475 VYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLK 534
+ + VME GGEL + R+R F+E A I ++YLHS+ VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 535 PSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDI 594
N++ D+ G I++ DFG K+ + + T C T ++APEVL+ Y A D
Sbjct: 278 LENLML-DKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 595 WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH 654
W LG+++Y M+ G PF N + E++ + ++ ++S AK +++ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
Query: 655 VDPHQRL-----TAMQVLKH 669
DP QRL A +V++H
Sbjct: 387 KDPKQRLGGGPSDAKEVMEH 406
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 93 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 330 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
Query: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
FT +S G P + A F GFS+
Sbjct: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 56 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 115
Query: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 116 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 175
Query: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 176 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 234
Query: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 235 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
Query: 606 AGFTPF 611
G PF
Sbjct: 292 YGLPPF 297
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 107 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 223
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 283
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 284 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 343
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 344 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 402
Query: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
FT +S G P + A F GFS+
Sbjct: 403 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 70 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 129
Query: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 130 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 189
Query: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 190 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 248
Query: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 249 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 305
Query: 606 AGFTPF 611
G PF
Sbjct: 306 YGLPPF 311
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 358 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
Query: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
FT +S G P + A F GFS+
Sbjct: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 84 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 143
Query: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 144 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 203
Query: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 204 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 262
Query: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 263 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
Query: 606 AGFTPF 611
G PF
Sbjct: 320 YGLPPF 325
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 283 bits (725), Expect = 3e-76
Identities = 154/335 (45%), Positives = 207/335 (61%), Gaps = 14/335 (4%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A PS F LKV+G+GS+GKV L R K + YA+KVL KKA LK ++ ER++
Sbjct: 188 AKPSDFHFLKVIGKGSFGKVLLARH-KAEEV--FYAVKVLQKKAILKKKEEKHIMSERNV 244
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
L +LHSL I+YRDLKPENILLD +GHI +TDFGL KE I+H+ +FCGT EY+APEV+
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
L +++ RLGA D EIK H FF I+W+ L K+I PPF P V P D HFDPE
Sbjct: 425 GLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
Query: 352 FTARTPTDSPGVPPSA--------NAHHLFRGFSF 378
FT +S G P + A F GFS+
Sbjct: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Score = 121 bits (303), Expect = 3e-27
Identities = 83/246 (33%), Positives = 118/246 (47%), Gaps = 15/246 (6%)
Query: 377 SFVASSLIQEPSQQDLHKVPVHPIVQQLH---GNNIHFTDG-YEIKEDIGVGSYSVCKRC 432
S + S QEP + + P QQ++ +N H + + IG GS+
Sbjct: 151 SILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLA 210
Query: 433 VHKATDTEYAVKIIDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLV 485
HKA + YAVK++ K ++ E +LL+ +HP ++ L + +Y V
Sbjct: 211 RHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFV 270
Query: 486 MELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESG 545
++ + GGEL + R+R F E A I + YLHS +V+RDLKP NIL D G
Sbjct: 271 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL-DSQG 329
Query: 546 SPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
I + DFG K+ N T C T ++APEVL +Q YD D W LG +LY ML
Sbjct: 330 ---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
Query: 606 AGFTPF 611
G PF
Sbjct: 387 YGLPPF 392
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 280 bits (716), Expect = 3e-75
Identities = 139/307 (45%), Positives = 201/307 (65%), Gaps = 5/307 (1%)
Query: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAE 115
++FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V + E +L
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 176 HS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 234
HS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALF 294
+ ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 295 KRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 354
K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT +FD EFTA
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 355 RTPTDSP 361
+ T +P
Sbjct: 445 QMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 468
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 527
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 587
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 648 VVSKMLHVDPHQRL-----TAMQVLKH 669
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 280 bits (716), Expect = 3e-75
Identities = 139/307 (45%), Positives = 201/307 (65%), Gaps = 5/307 (1%)
Query: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAE 115
++FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V + E +L
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 176 HS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 234
HS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALF 294
+ ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 295 KRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 354
K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT +FD EFTA
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 355 RTPTDSP 361
+ T +P
Sbjct: 445 QMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 468
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 527
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 587
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 648 VVSKMLHVDPHQRL-----TAMQVLKH 669
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 280 bits (716), Expect = 3e-75
Identities = 139/307 (45%), Positives = 201/307 (65%), Gaps = 5/307 (1%)
Query: 57 SQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAE 115
++FE LK+LG+G++GKV LV++ G+ YAMK+LKK + +D V + E +L
Sbjct: 148 NEFEYLKLLGKGTFGKVILVKE---KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 116 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 175
HPF+ L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+L
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYL 264
Query: 176 HS-LGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 234
HS ++YRDLK EN++LD++GHIKITDFGL KE I +FCGT EY+APEV+
Sbjct: 265 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 324
Query: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALF 294
+ ++ DWW GV+M+EM+ G LPF +D ++ LIL ++ P+ L EA+SLL L
Sbjct: 325 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL 384
Query: 295 KRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTA 354
K++P RLG G + +EI +H FF I W +Y K++ PPFKP V DT +FD EFTA
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444
Query: 355 RTPTDSP 361
+ T +P
Sbjct: 445 QMITITP 451
Score = 112 bits (280), Expect = 1e-24
Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 23/267 (8%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI------EILLRYGQHPN 468
+E + +G G++ KAT YA+KI+ K +E+ +L+ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-G 527
+ LK + + VME GGEL + R+R FSE A I +DYLHS+
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 587
VV+RDLK N++ D+ G I++ DFG K+ + T C T ++APEVL+
Sbjct: 270 VVYRDLKLENLML-DKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
Y A D W LG+++Y M+ G PF N + E++ + ++ ++ AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFP------RTLGPEAKS 378
Query: 648 VVSKMLHVDPHQRL-----TAMQVLKH 669
++S +L DP QRL A ++++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 278 bits (710), Expect = 2e-74
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 30 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 86
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 267 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 325
Query: 352 FTARTPTDSPGVPP-----SANAHHLFRGFSF 378
FT + S G P S+ A F GFS+
Sbjct: 326 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
Score = 119 bits (298), Expect = 1e-26
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 467
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 527
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
Query: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 587
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 155 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 210
Query: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 211 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 263
Query: 648 VVSKMLHVDPHQRL 661
++ +LH D QRL
Sbjct: 264 LLQSLLHKDQRQRL 277
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 278 bits (710), Expect = 2e-74
Identities = 149/332 (44%), Positives = 206/332 (62%), Gaps = 11/332 (3%)
Query: 54 ADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKMERDI 112
A P+ F+ LKV+G+G+YGKV L ++ G YA+KVL KK+ LK +++ ER +
Sbjct: 90 AQPTDFDFLKVIGKGNYGKVLLAKR---KSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 146
Query: 113 LAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
L + V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
Query: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVV 231
+ +LHSL IIYRDLKPENILLD +GH+ +TDFGL KE ++ + +FCGT EY+APEV+
Sbjct: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
Query: 232 NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLR 291
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPE 351
+L ++ RLG+ D + EIK H FF I+W+ LY K + PPF P V P D HFDPE
Sbjct: 327 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 385
Query: 352 FTARTPTDSPGVPP-----SANAHHLFRGFSF 378
FT + S G P S+ A F GFS+
Sbjct: 386 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
Score = 119 bits (298), Expect = 1e-26
Identities = 79/254 (31%), Positives = 125/254 (49%), Gaps = 18/254 (7%)
Query: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS----KRDPSE---EIEILLRYGQHP 467
++ + IG G+Y K+ YAVK++ K K++ S E +LL+ +HP
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 527
++ L+ + + +Y V++ + GGEL + R+R F E A + + YLHS
Sbjct: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
Query: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQG 587
+++RDLKP NIL + + + DFG K+ T C T ++APEVL+++
Sbjct: 215 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 270
Query: 588 YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKD 647
YD A D W LG +LY ML G PF + ++ I + GG + AA D
Sbjct: 271 YDRAVDWWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACD 323
Query: 648 VVSKMLHVDPHQRL 661
++ +LH D QRL
Sbjct: 324 LLQSLLHKDQRQRL 337
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 265 bits (678), Expect = 9e-71
Identities = 142/309 (45%), Positives = 195/309 (63%), Gaps = 6/309 (1%)
Query: 50 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKM 108
G A P+ F+ LKV+G+GS+GKV L ++ G+ YA+KVL KK L +++
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 109 ERDILAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167
ER++L + V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMA 227
+A AL +LHS+ I+YRDLKPENILLD GH+ +TDFGL KE I +FCGT EY+A
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLA 329
Query: 228 PEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQ 287
PEV+ ++ + + DWW G +++EML G PF +D E IL L + +S A
Sbjct: 330 PEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW 389
Query: 288 SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 347
S+L L +++ NRLGA D + EI+ HPFF ++ W L +K+I PPF P V P+D +
Sbjct: 390 SILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRN 448
Query: 348 FDPEFTART 356
FD FT T
Sbjct: 449 FDTAFTEET 457
Score = 112 bits (279), Expect = 2e-24
Identities = 87/298 (29%), Positives = 137/298 (45%), Gaps = 25/298 (8%)
Query: 386 EPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKI 445
E S Q LH + + + TD ++ + IG GS+ K YAVK+
Sbjct: 134 ERSSQKLHSTSQNINLGPSGNPHAKPTD-FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192
Query: 446 IDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI 498
+ K ++ E +LL+ +HP ++ L + + +Y V++ + GGEL +
Sbjct: 193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 499 LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA 558
R+R F E A I + YLHS +V+RDLKP NIL S + + DFG
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL----DSVGHVVLTDFGLC 308
Query: 559 KQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDD 617
K+ A + T C T ++APEV+++Q YD D W LG +LY ML G PF +
Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE 368
Query: 618 TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTA----MQVLKHPW 671
+ IL + S + +S W ++ ++L D RL A +++ HP+
Sbjct: 369 MYDNILHKPLSLRPGVSLTAW--------SILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 265 bits (678), Expect = 9e-71
Identities = 142/309 (45%), Positives = 195/309 (63%), Gaps = 6/309 (1%)
Query: 50 GFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL-KKATLKVRDRVRSKM 108
G A P+ F+ LKV+G+GS+GKV L ++ G+ YA+KVL KK L +++
Sbjct: 153 GNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 109 ERDILAE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167
ER++L + V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMA 227
+A AL +LHS+ I+YRDLKPENILLD GH+ +TDFGL KE I +FCGT EY+A
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLA 329
Query: 228 PEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQ 287
PEV+ ++ + + DWW G +++EML G PF +D E IL L + +S A
Sbjct: 330 PEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAW 389
Query: 288 SLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 347
S+L L +++ NRLGA D + EI+ HPFF ++ W L +K+I PPF P V P+D +
Sbjct: 390 SILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRN 448
Query: 348 FDPEFTART 356
FD FT T
Sbjct: 449 FDTAFTEET 457
Score = 112 bits (279), Expect = 2e-24
Identities = 87/298 (29%), Positives = 137/298 (45%), Gaps = 25/298 (8%)
Query: 386 EPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKI 445
E S Q LH + + + TD ++ + IG GS+ K YAVK+
Sbjct: 134 ERSSQKLHSTSQNINLGPSGNPHAKPTD-FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKV 192
Query: 446 IDKS-------KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRI 498
+ K ++ E +LL+ +HP ++ L + + +Y V++ + GGEL +
Sbjct: 193 LQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 499 LRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA 558
R+R F E A I + YLHS +V+RDLKP NIL S + + DFG
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL----DSVGHVVLTDFGLC 308
Query: 559 KQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDD 617
K+ A + T C T ++APEV+++Q YD D W LG +LY ML G PF +
Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE 368
Query: 618 TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTA----MQVLKHPW 671
+ IL + S + +S W ++ ++L D RL A +++ HP+
Sbjct: 369 MYDNILHKPLSLRPGVSLTAW--------SILEELLEKDRQNRLGAKEDFLEIQNHPF 418
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 263 bits (673), Expect = 3e-70
Identities = 146/358 (40%), Positives = 206/358 (57%), Gaps = 14/358 (3%)
Query: 30 SRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYA 89
S LE G+ + D + F D F VLG+G +GKV L + +++A
Sbjct: 631 SGLEYSGIQELEDRRSQQRFQFNLQD---FRCCAVLGRGHFGKVLLAEY---KNTNEMFA 684
Query: 90 MKVLKKATLKVRDRVRSKM-ERDILAEVN---HPFIVKLHYAFQTEGKLYLILDFLRGGD 145
+K LKK + RD V S M E+ I VN HPF+V L FQT+ + ++++ GGD
Sbjct: 685 IKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGD 744
Query: 146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL 205
L + +V F+E FY A + L L +LH I+YRDLK +N+LLD EG +KI DFGL
Sbjct: 745 LMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGL 803
Query: 206 SKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRK 265
KE + + R +FCGT E++APEV+ +T++ DWW GVL++EML G PF G D +
Sbjct: 804 CKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEE 863
Query: 266 ETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNT 325
E I+ ++ P+FLS EA S++R L +RNP RLGA E++K+HPFF IDW+
Sbjct: 864 EVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSA 923
Query: 326 LYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP---SANAHHLFRGFSFVA 380
L K++KPPF P + ED +FD EFT+ P +P P S +FR F ++A
Sbjct: 924 LMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIA 981
Score = 107 bits (267), Expect = 4e-23
Identities = 85/309 (27%), Positives = 138/309 (44%), Gaps = 28/309 (9%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILL---------RYGQHPNIIT 471
+G G + +K T+ +A+K + K +E++ L+ +HP ++
Sbjct: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
Query: 472 LKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHR 531
L + + V VME GG+L+ I FSE A + + YLH +V+R
Sbjct: 723 LFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
Query: 532 DLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAA 591
DLK N+L E +++ DFG K+ T C T F+APEVL Y A
Sbjct: 782 DLKLDNLLLDTEG----FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRA 837
Query: 592 CDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSK 651
D W LG+L+Y ML G +PF P D EE+ I + + +S A ++ +
Sbjct: 838 VDWWGLGVLIYEMLVGESPF---PGDDEEEVFDSIVNDEVRYP----RFLSTEAISIMRR 890
Query: 652 MLHVDPHQRLTAMQ-----VLKHPW--VVNREYLSPNQLSRQDVHLVKGAMAATYFALNR 704
+L +P +RL A + V KHP+ +++ L ++ + ++G + F
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950
Query: 705 TPQAPRLEP 713
T +AP L P
Sbjct: 951 TSEAPILTP 959
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 261 bits (667), Expect = 2e-69
Identities = 146/349 (41%), Positives = 211/349 (60%), Gaps = 11/349 (3%)
Query: 18 LRRK-SRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV 76
LR+K R+K S +++ EE + + ++ + F L VLG+GS+GKV L
Sbjct: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDN-NGNRDRMKLTDFNFLMVLGKGSFGKVMLS 359
Query: 77 RKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHP-FIVKLHYAFQTEGKL 134
+ KG+D +LYA+K+LKK + D V M E+ +LA P F+ +LH FQT +L
Sbjct: 360 ER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL 416
Query: 135 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE 194
Y +++++ GGDL + + F E FY AE+A+ L L S GIIYRDLK +N++LD
Sbjct: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476
Query: 195 EGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 254
EGHIKI DFG+ KE I +FCGT +Y+APE++ + + +S DWW+FGVL++EML
Sbjct: 477 EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536
Query: 255 GSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKR 314
G PF+G+D E I++ + P+ +S EA ++ + L ++P RLG G +G +IK
Sbjct: 537 GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596
Query: 315 HPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR----TPTD 359
H FF IDW L RKEI+PP+KP DT +FD EFT + TPTD
Sbjct: 597 HAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTD 645
Score = 103 bits (256), Expect = 7e-22
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 473
+G GS+ K TD YAVKI+ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 474 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 533
+ +Y VME + GG+L+ I + F E A I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 534 KPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACD 593
K N++ E I++ DFG K+ T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 594 IWSLGILLYTMLAGFTPFANGPDD 617
W+ G+LLY MLAG PF +D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 257 bits (657), Expect = 2e-68
Identities = 152/376 (40%), Positives = 222/376 (59%), Gaps = 16/376 (4%)
Query: 18 LRRK-SRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLV 76
LR+K R+K S +++ EE + + ++ + F L VLG+GS+GKV L
Sbjct: 301 LRQKFERAKISQGTKVPEEKTTNTVSKFDN-NGNRDRMKLTDFNFLMVLGKGSFGKVMLS 359
Query: 77 RKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHP-FIVKLHYAFQTEGKL 134
+ KG+D +LYA+K+LKK + D V M E+ +LA P F+ +LH FQT +L
Sbjct: 360 ER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRL 416
Query: 135 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDE 194
Y +++++ GGDL + + F E FY AE+A+ L L S GIIYRDLK +N++LD
Sbjct: 417 YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS 476
Query: 195 EGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 254
EGHIKI DFG+ KE I +FCGT +Y+APE++ + + +S DWW+FGVL++EML
Sbjct: 477 EGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA 536
Query: 255 GSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKR 314
G PF+G+D E I++ + P+ +S EA ++ + L ++P RLG G +G +IK
Sbjct: 537 GQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKE 596
Query: 315 HPFFVTIDWNTLYRKEIKPPFKP-AVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHL- 372
H FF IDW L RKEI+PP+KP A GR + +FD FT P +P P ++
Sbjct: 597 HAFFRYIDWEKLERKEIQPPYKPKACGRNAE--NFDRFFTRHPPVLTP--PDQEVIRNID 652
Query: 373 ---FRGFSFVASSLIQ 385
F GFSFV S ++
Sbjct: 653 QSEFEGFSFVNSEFLK 668
Score = 103 bits (256), Expect = 7e-22
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 421 IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQHPNIITLK 473
+G GS+ K TD YAVKI+ K +++E +L G+ P + L
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 474 DVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDL 533
+ +Y VME + GG+L+ I + F E A I + +L S+G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 534 KPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACD 593
K N++ E I++ DFG K+ T C T +++APE++ Q Y + D
Sbjct: 468 KLDNVMLDSEG----HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
Query: 594 IWSLGILLYTMLAGFTPFANGPDD 617
W+ G+LLY MLAG PF +D
Sbjct: 524 WWAFGVLLYEMLAGQAPFEGEDED 547
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 257 bits (656), Expect = 3e-68
Identities = 139/331 (41%), Positives = 197/331 (59%), Gaps = 10/331 (3%)
Query: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEV- 116
FE ++VLG+GS+GKV L R + G LYA+KVLKK + D V M E+ IL+
Sbjct: 355 FEFIRVLGKGSFGKVMLARV---KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 411
Query: 117 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 176
NHPF+ +L FQT +L+ +++F+ GGDL + K F E +FY AE+ AL LH
Sbjct: 412 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 471
Query: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 236
GIIYRDLK +N+LLD EGH K+ DFG+ KE I + +FCGT +Y+APE++ +
Sbjct: 472 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY 531
Query: 237 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKR 296
+ DWW+ GVL++EML G PF+ ++ + IL ++ P +L +A +L++ +
Sbjct: 532 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTK 591
Query: 297 NPCNRLGAGIDGVEE-IKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR 355
NP RLG+ G E I RHPFF IDW L ++I+PPF+P + ED +FDP+F
Sbjct: 592 NPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKE 651
Query: 356 TPTDSP---GVPPSANAHHLFRGFSFVASSL 383
P +P G P N FR FS+V+ L
Sbjct: 652 EPVLTPIDEGHLPMINQDE-FRNFSYVSPEL 681
Score = 109 bits (272), Expect = 1e-23
Identities = 87/318 (27%), Positives = 140/318 (44%), Gaps = 28/318 (8%)
Query: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIE-------ILLRYGQ 465
D +E +G GS+ K T YAVK++ K +++E IL
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
HP + L + ++ VME + GG+L+ I + R F E A I + +LH
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472
Query: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
+G+++RDLK N+L E ++ DFG K+ T C T +++APE+L+
Sbjct: 473 KGIIYRDLKLDNVLLDHEG----HCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
Query: 586 QGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISDA 644
Y A D W++G+LLY ML G PF A DD E IL + W + +
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL------NDEVVYPTW--LHED 580
Query: 645 AKDVVSKMLHVDPHQRLTAM------QVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAAT 698
A ++ + +P RL ++ +L+HP+ ++ N RQ + + +
Sbjct: 581 ATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNH--RQIEPPFRPRIKSR 638
Query: 699 YFALNRTPQAPRLEPVLS 716
N P + EPVL+
Sbjct: 639 EDVSNFDPDFIKEEPVLT 656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,727,842
Number of Sequences: 37866
Number of extensions: 1291903
Number of successful extensions: 7452
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 745
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 2672
Number of HSP's gapped (non-prelim): 1880
length of query: 733
length of database: 18,247,518
effective HSP length: 110
effective length of query: 623
effective length of database: 14,082,258
effective search space: 8773246734
effective search space used: 8773246734
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.