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Search of human proteins with 194595478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B
[Homo sapiens]
(455 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 927 0.0
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 927 0.0
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 927 0.0
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 927 0.0
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 927 0.0
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 787 0.0
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 535 e-152
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 275 6e-74
gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Ho... 269 4e-72
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 178 1e-44
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 176 4e-44
gi|134152694 guanylate cyclase 2F [Homo sapiens] 171 1e-42
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 166 3e-41
gi|222080083 guanylate cyclase 2C [Homo sapiens] 158 1e-38
gi|24497587 adenylate cyclase 4 [Homo sapiens] 122 5e-28
gi|115387102 adenylate cyclase 2 [Homo sapiens] 122 7e-28
gi|4557255 adenylate cyclase 7 [Homo sapiens] 118 1e-26
gi|31083193 adenylate cyclase 1 [Homo sapiens] 117 2e-26
gi|148536830 adenylate cyclase 3 [Homo sapiens] 117 3e-26
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 109 6e-24
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 109 6e-24
gi|34486092 adenylate cyclase 5 [Homo sapiens] 106 4e-23
gi|4557257 adenylate cyclase 8 [Homo sapiens] 101 1e-21
gi|50959205 adenylate cyclase 9 [Homo sapiens] 101 2e-21
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 30 5.9
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 30 5.9
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 29 7.7
gi|156104908 myosin heavy chain 6 [Homo sapiens] 29 7.7
gi|81295813 ADP-ribosylation factor-like 4A [Homo sapiens] 29 7.7
gi|47078227 ADP-ribosylation factor-like 4A [Homo sapiens] 29 7.7
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
Query: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 596 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 655
Query: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 656 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 596 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 655
Query: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 656 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 596 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 655
Query: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 656 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 927 bits (2397), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 420
LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH
Sbjct: 596 LFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICH 655
Query: 421 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 455
FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
Sbjct: 656 FLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID 690
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 787 bits (2032), Expect = 0.0
Identities = 389/389 (100%), Positives = 389/389 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 180
SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI
Sbjct: 356 SVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415
Query: 181 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 240
GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK
Sbjct: 416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAK 475
Query: 241 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 300
KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA
Sbjct: 476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVA 535
Query: 301 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 360
GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC
Sbjct: 536 GGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYC 595
Query: 361 LFGNNVTLANKFESCSVPRKINVSPTTYR 389
LFGNNVTLANKFESCSVPRKINVSPTTYR
Sbjct: 596 LFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 535 bits (1378), Expect = e-152
Identities = 266/417 (63%), Positives = 326/417 (78%), Gaps = 7/417 (1%)
Query: 36 PQSSLVIPTSL------FCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYF 89
PQ + +P L FC+ FPFH MFD M++LQ G G+R+ + R D FE+ F
Sbjct: 306 PQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQL-RCDTHKVLKFEDCF 364
Query: 90 EILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGS 149
EI++PK+N TF ++ L+ FV+R + + + +VM++KGQMI++ ES++ILFLGS
Sbjct: 365 EIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILFLGS 424
Query: 150 PCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALE 209
PCVD+L++ GRGL+LSDIPIH+A RDV+L+GEQA+AQDGLKKR+ KLKATLE+ HQALE
Sbjct: 425 PCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALE 484
Query: 210 EEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVIT 269
EEKKKTVDLL SIFP +VAQQLWQGQ VQA+KF +VTMLFSDIVGFTAIC+QC+P+QVI+
Sbjct: 485 EEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVIS 544
Query: 270 MLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVM 329
MLN LYTRFD QCG LD+YKVETIGDAYCVA GLH++S HA IALMALKMMELS+EV+
Sbjct: 545 MLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVL 604
Query: 330 SPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYR 389
+P G PI+MRIG+HSGSV AGVVGV+MPRYCLFGNNVTLA+KFES S PR+INVSPTTY+
Sbjct: 605 TPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQ 664
Query: 390 LLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 446
LLK F F PRSREELP NFP EIPGIC+FL+ KP ++ + N
Sbjct: 665 LLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKKVSYN 721
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 275 bits (703), Expect = 6e-74
Identities = 162/372 (43%), Positives = 225/372 (60%), Gaps = 20/372 (5%)
Query: 37 QSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKI 96
Q S + P + FCK FPFH +FD+D+ + Q GN I R++ + G + F ++ P I
Sbjct: 204 QESRISPYT-FCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQ-PGNCSLLSVFSLVRPHI 261
Query: 97 NQTFSGIMTMLNMQFVVRVRRWDNSVKKSS----------RVMDLKGQMIYIVESSAILF 146
+ +F GI++ +N FV+R + V+K + LKGQMIY+ E+ +ILF
Sbjct: 262 DISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILF 321
Query: 147 LGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQ 206
L SP V L+D T RGLYLSDIP+H+A RD+VL+GEQ R + L + L L L+ +
Sbjct: 322 LCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLR 381
Query: 207 ALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCS--- 263
ALE+EKKKT LL S+ P VA +L + V AK++ NVT+LFS IVGF A CS+ +
Sbjct: 382 ALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGE 441
Query: 264 -PLQVITMLNALYTRFDQQCGELD---VYKVETIGDAYCVAGGLHKESDTHAVQIALMAL 319
++++ +LN LYTRFD VYKVET+GD Y GL + HA I +AL
Sbjct: 442 GAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLAL 501
Query: 320 KMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPR 379
MME++ +V GE +++ IG+H+G V GV+G +MPRYCLFGN V L ++ E+
Sbjct: 502 DMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKG 560
Query: 380 KINVSPTTYRLL 391
KINVS TYR L
Sbjct: 561 KINVSEYTYRCL 572
>gi|194595480 guanylate cyclase 1, soluble, alpha 3 isoform C [Homo
sapiens]
Length = 366
Score = 269 bits (687), Expect = 4e-72
Identities = 128/128 (100%), Positives = 128/128 (100%)
Query: 1 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 60
MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD
Sbjct: 236 MPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKD 295
Query: 61 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 120
MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN
Sbjct: 296 MTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDN 355
Query: 121 SVKKSSRV 128
SVKKSSRV
Sbjct: 356 SVKKSSRV 363
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 178 bits (451), Expect = 1e-44
Identities = 99/221 (44%), Positives = 141/221 (63%), Gaps = 3/221 (1%)
Query: 190 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 249
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 820 MEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 879
Query: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 308
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 880 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGR 939
Query: 309 THAVQIALMALKMMEL--SDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 366
HA ++A MAL +++ S + E +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 940 LHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTV 999
Query: 367 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 407
A++ ES KI++S T +L++ GF R E+
Sbjct: 1000 NTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEM 1040
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 176 bits (446), Expect = 4e-44
Identities = 100/221 (45%), Positives = 138/221 (62%), Gaps = 3/221 (1%)
Query: 190 LKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLF 249
+++ L+ +E+ QA EEK+K LL I P VA+QL +G+ VQA+ F +VT+ F
Sbjct: 805 MEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYF 864
Query: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL-HKESD 308
SDIVGFTA+ ++ +P+QV+T+LN LYT FD DVYKVETIGDAY V GL +
Sbjct: 865 SDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQ 924
Query: 309 THAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV 366
HA +IA MAL +++ H + +++RIG+H+G V AGVVG+KMPRYCLFG+ V
Sbjct: 925 RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTV 984
Query: 367 TLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREEL 407
A++ ES KI+VS TT L + F R E+
Sbjct: 985 NTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEM 1025
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 171 bits (434), Expect = 1e-42
Identities = 102/235 (43%), Positives = 143/235 (60%), Gaps = 8/235 (3%)
Query: 181 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 236
G++ D + + L + + LE + + LE EK+KT LL + P VA+ L +G
Sbjct: 815 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCT 874
Query: 237 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 296
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 875 VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 934
Query: 297 YCVAGGLHKESDT-HAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 353
Y VA GL K + + HA +IA M+L ++ H P+++RIGLHSG V AGVVG
Sbjct: 935 YMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVG 994
Query: 354 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD-CPGFVFTPRSREEL 407
+ MPRYCLFG+ V A++ ES +P +I+VS +T +L++ G+ R R EL
Sbjct: 995 LTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 166 bits (421), Expect = 3e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 181 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 236
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
Query: 237 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 296
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
Query: 297 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 353
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Query: 354 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 412
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
Query: 413 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 446
+ F ++G N KP + D++ G++N
Sbjct: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 158 bits (399), Expect = 1e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 197 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 256
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
Query: 257 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 315
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
Query: 316 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 373
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
Query: 374 SCSVPRKINVSPTTYRLLK 392
S +P +I+VS +T +LK
Sbjct: 955 STGLPLRIHVSGSTIAILK 973
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 122 bits (307), Expect = 5e-28
Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)
Query: 197 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 235
L+AT +A + L+ EKK LL SI P E+ +L GQ
Sbjct: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
Query: 236 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 291
+ K+ V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ E + +++
Sbjct: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
Query: 292 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 351
+GD Y GL HA+ M L M ++ + G I MR+G+HSGSV GV
Sbjct: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
Query: 352 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
+G++ +Y ++ ++VTLAN E+ VP +++++ T LL
Sbjct: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
Score = 72.8 bits (177), Expect = 6e-13
Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)
Query: 198 KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 253
K L Q + E + T LL ++ P VA Q + + + + + V +LF+ +
Sbjct: 821 KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
Query: 254 GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 306
F S+ + L+ + +LN + FD+ + V K++TIG Y A GL+
Sbjct: 881 DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
Query: 307 SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 355
S A Q A + M+E + +V++ H ++R+GL+ G V AGV+G +
Sbjct: 941 SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
Query: 356 MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 387
P+Y ++GN V +A++ ES V KI V+ T
Sbjct: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 122 bits (306), Expect = 7e-28
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 247
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
Query: 248 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 307
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
Query: 308 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 367
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
Query: 368 LANKFESCSVPRKINVSPTT 387
LAN E+ VP ++++S T
Sbjct: 412 LANHMEAGGVPGRVHISSVT 431
Score = 65.5 bits (158), Expect = 1e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 209 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 259
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
Query: 260 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 304
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
Query: 305 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 361
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
Query: 362 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 392
+GN V +A++ +S V KI V+ T +L+
Sbjct: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 118 bits (295), Expect = 1e-26
Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)
Query: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 243
Q + L EK++ +LL S+ P ++ + + + K+
Sbjct: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
Query: 244 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 303
NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ + +++ +GD Y GL
Sbjct: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
Query: 304 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 363
THA M L M + +V G I MR+G+HSG+V GV+G++ +Y ++
Sbjct: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
Query: 364 NNVTLANKFESCSVPRKINVSPTTYRLL 391
++V+LAN+ E+ VP +++++ T + L
Sbjct: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)
Query: 198 KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 254
K ++ H+ E + LL ++ P VA ++ + + + V ++F+ +
Sbjct: 828 KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
Query: 255 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 303
F ++C L+ + +LN + FD+ + V K++TIG Y A GL
Sbjct: 888 FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
Query: 304 ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
++E + I +M ++ +M D + ++R+G++ G V AGV+G + P
Sbjct: 948 GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
Query: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 398
+Y ++GN V +A++ ES KI V+ T +L+ +C G +
Sbjct: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 117 bits (294), Expect = 2e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 258
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
Query: 259 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 318
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
Query: 319 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 378
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
Query: 379 RKINVSPTTYRLL 391
K++++ TT L
Sbjct: 436 GKVHITKTTLACL 448
Score = 88.6 bits (218), Expect = 1e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 199 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 254
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
Query: 255 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 307
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
Query: 308 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 359
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
Query: 360 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 395
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 117 bits (292), Expect = 3e-26
Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 13/198 (6%)
Query: 208 LEEEKKKTVDLLCSIFPCEVAQQLW-------------QGQVVQAKKFSNVTMLFSDIVG 254
LEE+ ++ +L+ SI P VA ++ Q + + NV++LF+DIVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 255 FTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQI 314
FT + S CS +++ +LN L+ RFD+ + +++ +GD Y GL + HAV
Sbjct: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCS 387
Query: 315 ALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFES 374
LM L M+E V + MR+G+H+G+V GV+G K +Y ++ +VT+ANK E+
Sbjct: 388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEA 447
Query: 375 CSVPRKINVSPTTYRLLK 392
+P ++++S +T LK
Sbjct: 448 GGIPGRVHISQSTMDCLK 465
Score = 65.9 bits (159), Expect = 7e-11
Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 30/248 (12%)
Query: 184 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQA 239
+R + L + L K + + + E ++ L+ ++ P VA+ + + + +
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 240 KKFSNVTMLFSDIVGFTAICSQCS----PLQVITMLNALYTRFDQQCGELD---VYKVET 292
+ + + ++F+ + F ++ S ++ + LN + + FD + K++T
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 293 IGDAYCVAGGLHKESDT------------------HAVQIALMALKMMELSDEVMSPHGE 334
IG Y A G+ + +T H +A AL M + + +
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 335 PIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC 394
+RIG++ G V AGV+G + P Y ++GN V +A++ ES V I V T +L++
Sbjct: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
Query: 395 PGFVFTPR 402
GF F R
Sbjct: 1097 -GFRFVRR 1103
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 109 bits (272), Expect = 6e-24
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 252
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
Query: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
Query: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
Query: 373 ESCSVPRKINVSPTTYRLL 391
E+ +I+++ T + L
Sbjct: 506 EAGGRAGRIHITRATLQYL 524
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 194 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
Query: 250 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
Query: 303 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
Query: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 109 bits (272), Expect = 6e-24
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 252
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
Query: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
Query: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
Query: 373 ESCSVPRKINVSPTTYRLL 391
E+ +I+++ T + L
Sbjct: 506 EAGGRAGRIHITRATLQYL 524
Score = 80.5 bits (197), Expect = 3e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 194 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 872 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
Query: 250 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 930 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
Query: 303 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 990 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
Query: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 106 bits (265), Expect = 4e-23
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 252
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
Query: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
Query: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
Query: 373 ESCSVPRKINVSPTTYRLL 391
E+ +I+++ T L
Sbjct: 596 EAGGKAGRIHITKATLNYL 614
Score = 83.6 bits (205), Expect = 3e-16
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 194 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
Query: 250 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
Query: 303 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
Query: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 101 bits (252), Expect = 1e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 249
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
Query: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 309
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
Query: 310 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 369
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
Query: 370 NKFESCSVPRKINVSPTT 387
NK ES +P +I++S T
Sbjct: 538 NKLESGGIPGRIHISKAT 555
Score = 94.0 bits (232), Expect = 3e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 263
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
Query: 264 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 310
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
Query: 311 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 370
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
Query: 371 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 402
+ +S V +I V TY +LKD GF F R
Sbjct: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 101 bits (251), Expect = 2e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 240 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 298
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
Query: 299 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 358
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
Query: 359 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 393
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
Score = 63.5 bits (153), Expect = 4e-10
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 218 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 275
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
Query: 276 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 325
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
Query: 326 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 384
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
Query: 385 PTTYRLL 391
+YR+L
Sbjct: 1210 EESYRVL 1216
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 29.6 bits (65), Expect = 5.9
Identities = 38/161 (23%), Positives = 66/161 (40%), Gaps = 35/161 (21%)
Query: 182 EQARAQDGLKKRLGKLKATLE--------QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQ 233
EQ R Q+ L++RL + K LE +A +ALE EK+K DL +
Sbjct: 744 EQTRVQE-LEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDL--------------E 788
Query: 234 GQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE-- 291
+ Q K+ S + + A+ + +Q L R +Q EL++ + +
Sbjct: 789 NHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQ------DLENRLTKQKEELELKEQKED 842
Query: 292 ----TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEV 328
+ DA + K T +++ +ALK+ E E+
Sbjct: 843 VLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAEL 883
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 29.6 bits (65), Expect = 5.9
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 182 EQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQL 231
E RA+D + R+ +L A E+A Q L E ++ + L S+ P ++L
Sbjct: 873 ELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRL 922
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 29.3 bits (64), Expect = 7.7
Identities = 14/36 (38%), Positives = 24/36 (66%)
Query: 184 ARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLL 219
A+ +D L+++L LK +L+ +LEEEK++ D L
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL 729
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 29.3 bits (64), Expect = 7.7
Identities = 33/144 (22%), Positives = 69/144 (47%), Gaps = 14/144 (9%)
Query: 170 IHNALRDV-VLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVA 228
+ + L+D + + + RA D LK+ + A +E+ + L+ E + +L + E +
Sbjct: 1648 LQSLLKDTQIQLDDAVRANDDLKENI----AIVERRNNLLQAELE---ELRAVVEQTERS 1700
Query: 229 QQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQV-ITMLNALYTRFDQQCGELDV 287
++L + ++++ + V +L S T++ +Q ++ +T L + Q+C +
Sbjct: 1701 RKLAEQELIETSE--RVQLLHSQN---TSLINQKKKMESDLTQLQSEVEEAVQECRNAEE 1755
Query: 288 YKVETIGDAYCVAGGLHKESDTHA 311
+ I DA +A L KE DT A
Sbjct: 1756 KAKKAITDAAMMAEELKKEQDTSA 1779
>gi|81295813 ADP-ribosylation factor-like 4A [Homo sapiens]
Length = 200
Score = 29.3 bits (64), Expect = 7.7
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 8/113 (7%)
Query: 102 GIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGR 161
GI+ +++ V R+ + K +R+ + +G + IV + L S + +E
Sbjct: 95 GIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDL-RNSLSLSEIEKLLAM 153
Query: 162 GLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKK 214
G S P H +IG DGLK+ L KL + + + L ++KKK
Sbjct: 154 GELSSSTPWH-LQPTCAIIG------DGLKEGLEKLHDMIIKRRKMLRQQKKK 199
>gi|47078227 ADP-ribosylation factor-like 4A [Homo sapiens]
Length = 200
Score = 29.3 bits (64), Expect = 7.7
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 8/113 (7%)
Query: 102 GIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGR 161
GI+ +++ V R+ + K +R+ + +G + IV + L S + +E
Sbjct: 95 GIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDL-RNSLSLSEIEKLLAM 153
Query: 162 GLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKK 214
G S P H +IG DGLK+ L KL + + + L ++KKK
Sbjct: 154 GELSSSTPWH-LQPTCAIIG------DGLKEGLEKLHDMIIKRRKMLRQQKKK 199
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,450,512
Number of Sequences: 37866
Number of extensions: 777906
Number of successful extensions: 1909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1849
Number of HSP's gapped (non-prelim): 50
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.