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Search of human proteins with 194306535
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194306535 coiled-coil domain containing 77 isoform b [Homo
sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap... 896 0.0
gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 74 4e-13
gi|34577114 cytomatrix protein p110 [Homo sapiens] 72 1e-12
gi|16262452 cingulin [Homo sapiens] 69 7e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 3e-11
gi|38044112 restin isoform b [Homo sapiens] 67 3e-11
gi|4506751 restin isoform a [Homo sapiens] 67 3e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 6e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 1e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 65 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 1e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 65 1e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 65 1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 3e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 3e-10
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 64 4e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 64 4e-10
gi|71061468 centromere protein E [Homo sapiens] 64 4e-10
gi|8922940 gamma-taxilin [Homo sapiens] 64 4e-10
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 8e-10
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 62 8e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 1e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 62 1e-09
gi|148746195 trichohyalin [Homo sapiens] 62 1e-09
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 62 1e-09
>gi|194306660 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|194306658 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|14150165 coiled-coil domain containing 77 isoform a [Homo
sapiens]
Length = 488
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 33 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92
Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 93 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152
Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212
Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272
Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332
Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452
Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
>gi|194306535 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 73.6 bits (179), Expect = 4e-13
Identities = 90/401 (22%), Positives = 185/401 (46%), Gaps = 37/401 (9%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
L Y Q + + E E DL+ +L K +L+Q +A QK +D +
Sbjct: 134 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 185
Query: 87 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140
+ L L + + EL++K K+Q L LV ++ E+ KE K+
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 245
Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194
+ Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQ 305
Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
+ ++ EQ + R Q E + E + ++ ++ + KI+EL + +H +++ +
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-KIRELEEKMHEQEKIREQEE 364
Query: 255 K--DFLQLRSENQNKE---KSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESH 307
K + ++R + + +E K W E+ KI++ +++E+K+G+ M E
Sbjct: 365 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424
Query: 308 HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL 367
E + ++ QE+K+ +EQ + E+ +IRE+E M +E + + GK
Sbjct: 425 EEMQEQEEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 368 QIMTKRYEALERRRILEVEGFKTDIKVLRQ--KLKDLEQML 406
+ K E E+ R E + + + K+ Q K+++ E+M+
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Score = 70.5 bits (171), Expect = 3e-12
Identities = 94/464 (20%), Positives = 213/464 (45%), Gaps = 66/464 (14%)
Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69
SPED H +E L ++ E + + +L +K EL QH ++ Q E
Sbjct: 94 SPEDEQKASHQHQEAL----RRELEAQVQTIRILTCQKTELQMALYYSQHAVK----QLE 145
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
E +L L D E E L + + R +E+ K ++ L+L + T
Sbjct: 146 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 201
Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181
+E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H
Sbjct: 202 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 257
Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRNQNKIKELT 240
+++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + KI+E
Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ--EEKIREQE 315
Query: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
+ + +E+++E + E +++ M EK+ + ++++ + +K ++
Sbjct: 316 EKMRRQEEMMWE--------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ----- 362
Query: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
E + E I+ + + QE K+ QE+ I +EE +IRE+E E+ +++
Sbjct: 363 ----EEKRQEEEKIREQEKRQEQEAKMWR--QEEKIREQEE--KIREQE----EMMQEQE 410
Query: 361 NKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR 414
KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+ + +
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEK 468
Query: 415 ANQDLALLCE----VRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+ +CE +++ + + + +++ + K+ E ++R
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Score = 60.5 bits (145), Expect = 3e-09
Identities = 75/361 (20%), Positives = 163/361 (45%), Gaps = 53/361 (14%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
LP + + H KEL K A+ E ENE L +L +E E + E +Q+RE
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVE-ENE-LWNRLNQQQE--EKMWRQEEKIQERE 301
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE---LEDKKKIQNLLALVGTDAG 126
E+I E ++ + + + + ++ E ++ + +++R +E E ++KI+ L
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKIREL--------- 349
Query: 127 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDI 186
+E H+ Q+ I+ E Q E + + + + ++E + I
Sbjct: 350 ------EEKMHE----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399
Query: 187 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246
+ ++ + ++GEQ + EQ E ++E + + +R + KI+E K +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEE--------EMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 247 QELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS-----------KIKQYRVQCKKKEDK 295
+E + E ++ +Q + E +++ M E++ M KI++ + +++E+K
Sbjct: 452 EEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Query: 296 IGKVLPVMHESHHAQSEYIKSL--KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353
I + +M E E + + +++ +QE++ QE+ + E+ R+R++E +
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMREQEVRLRQQEEKMQ 568
Query: 354 E 354
E
Sbjct: 569 E 569
Score = 58.9 bits (141), Expect = 9e-09
Identities = 84/406 (20%), Positives = 184/406 (45%), Gaps = 45/406 (11%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++
Sbjct: 177 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 236
Query: 84 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136
L ER +L +L +E D L K++Q++ A + E + + +
Sbjct: 237 RKL--ERAKLLLPQQQLQAEADHLG-------KELQSVSAKLQAQVEENELWNRLNQQQE 287
Query: 137 HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR--ERKESSEHYQRDIQTLILQVE 194
K+ ++ IQ E Q + + + +R+ E++E + + ++
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHTQELL 250
L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + + +E++
Sbjct: 348 ELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 251 YESTKDFLQLRSENQNKEKSW-----MLEKDNLM----SKIKQYRVQCKKKEDKIGKVLP 301
E Q + +EK W M E++ M KI++ + +++E+KI +
Sbjct: 407 QE------QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 302 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR---EIFKD 358
+M E E + ++ + ++ + Q + E+ +IRE+E R E+ ++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520
Query: 359 RTNKMGKRLQIMTKRYEAL----ERRRILEVEGFKTDIKVLRQKLK 400
+ KM ++ + M ++ E + E+ R E + + ++++ +Q+ K
Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 71.6 bits (174), Expect = 1e-12
Identities = 105/468 (22%), Positives = 206/468 (44%), Gaps = 63/468 (13%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
Q K+ +N D + +E+ KE+ + + LQ E+ L+ L + + L ++
Sbjct: 454 QTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT---EVDALRLRLEEKESFLNKKT 510
Query: 91 EHVLRLYSENDRL--RIRELED------------KKKIQNLLALVGTDAGEVTYFCKEPP 136
+ + L E L IR+++D +KKI+NL + ++T
Sbjct: 511 KQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVK 570
Query: 137 HKVTILQKTIQAVGECEQ--SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194
T T A+ E+ SE K + R RER E E ++++ + L +V
Sbjct: 571 SLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVN 630
Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
ALQA+L E+ E + D + H + + +K+K L + +E E +
Sbjct: 631 ALQAELTEK--------ESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE---ECS 679
Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQ-------YRVQCKKKEDKIGKVLPVMHESH 307
K QL+ + ++ S M +IKQ YR +C K + ++ ++L ++ E
Sbjct: 680 KLEAQLKKAHNIEDDSRM--NPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737
Query: 308 HAQSEYIK--------SLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359
+ +++ K +L+ Q KK++N+ Q + +++ A++ EE R + D
Sbjct: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE-KKKNAQLLEEVRRREDSMADN 796
Query: 360 T---------NKMGKRLQIM--TKRYEALERRRILEVEGFKTDIKVLRQK-LKDLEQMLY 407
+ N + K Q + TK A ++ + E E ++++ R+K L+++ +M
Sbjct: 797 SQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQ 856
Query: 408 KATVNARANQDLAL-LCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+A + A + +D + L E+ S ++ K Q E+ LK + L ++L+
Sbjct: 857 EALLAAISEKDANIALLELSASKKK--KTQEEVMALKREKDRLVHQLK 902
Score = 35.8 bits (81), Expect = 0.083
Identities = 33/147 (22%), Positives = 71/147 (48%), Gaps = 13/147 (8%)
Query: 273 LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332
L+K+ ++ K + R+ K++ + V HE + I++L+D+L ++ L+++ Q
Sbjct: 190 LKKERVLRKEEAARMSVLKEQ------MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ 243
Query: 333 EQCISLEEELARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTD 391
++ + E I EE RR + ++ K L ++ K E +E L +E K
Sbjct: 244 QESGNRGAEHFTIELTEENFRR--LQAEHDRQAKELFLLRKTLEEME----LRIETQKQT 297
Query: 392 IKVLRQKLKDLEQMLYKATVNARANQD 418
+ + +K L +ML + +++ +D
Sbjct: 298 LNARDESIKKLLEMLQSKGLPSKSLED 324
Score = 31.2 bits (69), Expect = 2.0
Identities = 30/153 (19%), Positives = 60/153 (39%), Gaps = 20/153 (13%)
Query: 294 DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 353
D+ G + H HH ++ ++D + + L+ +L ++ E + R
Sbjct: 119 DQHGGLTGSSHHHHHQVPSMLRQVRDSTM-------------LDLQAQLKELQRENDLLR 165
Query: 354 EIFKDRTNKMGKRLQ-IMTKRYEALERRRILEVEG------FKTDIKVLRQKLKDLEQML 406
+ + +K+G + I T L++ R+L E K ++V ++ + L+ +
Sbjct: 166 KELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTI 225
Query: 407 YKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439
R +DL L + NR A EL
Sbjct: 226 QALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/472 (20%), Positives = 198/472 (41%), Gaps = 74/472 (15%)
Query: 42 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101
+DLL+ EL +E EG+ ++E L+ RE E+ L+ AL + QE EHV + Y +
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
Query: 102 RLRIRELED--------KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE 153
R ++D + + Q + ALV E+ +E H ++ QK + + +
Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
Query: 154 Q--------SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QT 204
Q E + KI + E+ +S R ++ L ++ Q +L E Q
Sbjct: 587 QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
Query: 205 KLSREQIEGLIEDRRI---------------HLEEIQVQHQRNQNKIKE----------- 238
+ +++ G DR + LEE +Q Q+ ++++
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
Query: 239 --------------LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLE-KDNLMSKIK 283
+ L TQE E + L L E Q KE +++ + + ++++
Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL--EQQLKETRGLVDGGEAVEARLR 764
Query: 284 QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ-EKKLSNMYQEQCISLEEEL 342
+ + ++ ++ + L E + + ++L+ +L + ++ L+ + QEQ + L
Sbjct: 765 DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ-----QTL 819
Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDL 402
R EEEG +RE+ + ++ ++ +++ + + L + E K ++ L+ +L+D
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 403 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
++ + +A+ + +D A K G L L+ ++ L L+
Sbjct: 880 KEKARREVADAQR--------QAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
Score = 39.3 bits (90), Expect = 0.007
Identities = 57/252 (22%), Positives = 116/252 (46%), Gaps = 31/252 (12%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD----LQQRE 69
+D + +L ++ L+ Q + + E L ++L+ ++ E + + + D L+ E
Sbjct: 912 QDEIQRL---RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL----LALVGTDA 125
E+++ L+ L + + + + V R + D+LR ++++ Q+L ++L +
Sbjct: 969 EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNK 1028
Query: 126 GEVTYFC-----KEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS- 179
T ++P ++ L+ Q + E Q+E K + + R+ R+ KE S
Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLERKVKELSI 1087
Query: 180 ------EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN- 232
+H L L+V+AL+ Q+ E + E+IE L R+ E++ QH+ N
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDE----AEEEIERLDGLRKKAQREVEEQHEVNE 1143
Query: 233 --QNKIKELTKN 242
Q +IK L K+
Sbjct: 1144 QLQARIKSLEKD 1155
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.4 bits (163), Expect = 3e-11
Identities = 110/472 (23%), Positives = 208/472 (44%), Gaps = 88/472 (18%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD------------LQQREEE 71
KEL Q +M E ++L K LE KEA Q KLE + L+Q E+E
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASH-QLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131
+LQ +++++ Q+++ + L E L+I L+ K +++N L T A +
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGE---LKIAVLQ-KTELENKLQQQLTQAAQELAA 1009
Query: 132 CKEPPHKVTILQ----------KTIQAVGECEQSESSAFKADPKISKRRPSRERKE--SS 179
KE K+++LQ K +Q+ +SE A + D K + + S +++ S+
Sbjct: 1010 EKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
+ + LI +++ +A L EQ +EQ +++R L++IQ + + ++
Sbjct: 1067 RNQIGNQNKLIQELKTAKATL-EQDSAKKEQ---QLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
L +E+ K+ +L E ++ + + E NL KQ +Q +K + GK
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-KDAKQLLIQ--QKLELQGKA 1179
Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELAR--IREEEGMRREIFK 357
SLK + QEK+ + ++Q EEEL + I +E + EI
Sbjct: 1180 ---------------DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI-- 1222
Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLR-------QKLKDLEQM----- 405
K ++ K++E E + +++ ++ ++ +++ +LE+
Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 406 ----LYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453
+ +ATV ++ ALL R K +GE++ L++KV L+ +L
Sbjct: 1276 GEIAVLEATVQNNQDERRALL-------ERCLKGEGEIEKLQTKVLELQRKL 1320
Score = 50.8 bits (120), Expect = 2e-06
Identities = 83/464 (17%), Positives = 193/464 (41%), Gaps = 56/464 (12%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
Q + E + +E+L K+LE Y+ + + K + + E+ L++ L + Q F +
Sbjct: 96 QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155
Query: 91 EHVLRLYSENDRLRIRELED-KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ----KT 145
+ + L+ + E+ D K K +L +VT +E + T++Q +
Sbjct: 156 Q-MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205
+Q G + + + + ER+ SE + + + L Q + +A + +
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL-- 272
Query: 206 LSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQ 265
R ++ ++ ++++E+Q + ++ + ELT+ E L + +D+ +L E
Sbjct: 273 --RSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDYTKLE-EKH 325
Query: 266 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH---HAQSEYIKSLKDKL- 321
N+E + K N+ + + Q + C++ + ++ +H H + E + LK++L
Sbjct: 326 NEES---VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 322 ----------VQEKKLSNMYQEQ---CISLEEEL------------------ARIREEEG 350
+ K+L +E+ + L+ E+ R++E+
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKAT 410
+ E D+ ++ LQ+ R E + ++ + + +Q+ ++ + + T
Sbjct: 443 LSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Query: 411 VNAR-ANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
R A DL +L ++ D +++ ++ L+ K + LE E
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Score = 47.4 bits (111), Expect = 3e-05
Identities = 79/406 (19%), Positives = 168/406 (41%), Gaps = 51/406 (12%)
Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132
A+LQ L Q L +++ + ++ ++ D++ + L+DK++ ++
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-LQDKQE----------HCSQLESHL 711
Query: 133 KEPPHK-VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLIL 191
KE K +++ QKT + G+ ++ E+ + + + S+E+ QR + T
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEV-------KASKEQALQDLQQQRQLNT--- 761
Query: 192 QVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR--NQNKIKELTKN----LHH 245
+E +L +Q ++ +E + D + E ++ Q+ Q + K++ K L
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 246 TQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305
++ +E + +Q K K +EK+ LM+++ + + K D + +
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVK---MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 306 SHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGK 365
+ I L+ + K + E + ++EL + E+E K N M +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 366 RL---QIMTKRYEALER--------------RRILEVEGFKTDIKVLRQKLKDLEQMLYK 408
+L Q K+ E E+ ++ ++E + ++K+ + +LE L +
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998
Query: 409 ATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENEL 453
+A Q+LA E + K Q K L+S +G E+EL
Sbjct: 999 QL--TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Score = 45.8 bits (107), Expect = 8e-05
Identities = 69/421 (16%), Positives = 182/421 (43%), Gaps = 24/421 (5%)
Query: 18 AKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQK 77
A LH + Q +++ E + +L E E KL+ +L + E + L+
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELS---EKGEATQKLKEELSEVETKYQHLKA 393
Query: 78 ALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH 137
+Q ++ +H L+L SE ++L + LE ++++ + + +
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 138 KVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKESSEHYQ----RDIQTLILQ 192
+V LQ + + E ++ +++ + ++ K + + +++ + R+ Q
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---D 510
Query: 193 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE---LTKNLHHTQEL 249
+E + Q+G++ + + +E L++ + ++ ++ + + KI+ T L+ QE
Sbjct: 511 LEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 250 LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309
+ + QL + +N+ +S ++NL ++++ + + +D++ + ++E +
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL-- 367
+E + + +Q K + + + + A ++ + +D+ ++ K
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 368 --QIMTKRYEALERRRILE--VEGFKTDIKVLRQKLKDLEQMLYKA---TVNARANQDLA 420
Q+ K + E LE ++ +K L QK ++LE + K ++ +A+++ A
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 421 L 421
L
Sbjct: 750 L 750
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/301 (18%), Positives = 134/301 (44%), Gaps = 45/301 (14%)
Query: 42 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 101
+D KK + +E C+ ++ + +E+E+ + L++++ ++ + + +L N+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NE 1145
Query: 102 RLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA-- 159
L+ +LE K+I NL DA K ++Q+ ++ G+ + +++
Sbjct: 1146 ELKSHKLESIKEITNL-----KDA------------KQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 160 FKADPKISKRRPSRERKESSEHY---QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216
K + +I K + +E +E + + + + + I + E + E QI L E
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248
Query: 217 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK- 275
+L ++ + Q +Q ++ EL K T +L E L+ +N E+ +LE+
Sbjct: 1249 ----NLGTVKKEWQSSQRRVSELEK---QTDDLRGEIA--VLEATVQNNQDERRALLERC 1299
Query: 276 -------DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
+ L +K+ + + +K ++ V + E+ Q ++ ++L K ++ ++
Sbjct: 1300 LKGEGEIEKLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Query: 329 N 329
N
Sbjct: 1357 N 1357
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 67.0 bits (162), Expect = 3e-11
Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68
L + ++ L+++ KE LE + + E AE +E+ + +E H+ E
Sbjct: 786 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845
Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118
++ +L++ L+DM+ ++ E +L END I ++ K+ + L
Sbjct: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
Query: 119 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177
L D E+ + + LQK+I+ + + EQS+ A K K + + ERK
Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 962
Query: 178 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233
S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N
Sbjct: 963 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282
++EL + + T + E KEK+ L N + +
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398
R R+E +++ ++R + + +L M KR + E + I + L +K
Sbjct: 1141 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199
Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+LE++ + TV N L V ++ + L+ KV LE +L+
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1249
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)
Query: 60 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
+LE DL R +E+AEL++ L DM + L QE + S ++L + + +
Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 521
Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171
++I +L G A E T+ KE T +K + + A K + +
Sbjct: 522 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231
S+ + H Q + + + L + E +L + QIE + D + +E +Q Q
Sbjct: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 637
Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
+ KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347
+ L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+
Sbjct: 698 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749
Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
+ + K K L+I + E++G + + L++ L ++ Q
Sbjct: 750 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 798
Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
V ++L +L E +++ A +Q ++ +K+ E + +
Sbjct: 799 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 844
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 67.0 bits (162), Expect = 3e-11
Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 68
L + ++ L+++ KE LE + + E AE +E+ + +E H+ E
Sbjct: 821 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 880
Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 118
++ +L++ L+DM+ ++ E +L END I ++ K+ + L
Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940
Query: 119 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 177
L D E+ + + LQK+I+ + + EQS+ A K K + + ERK
Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 997
Query: 178 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 233
S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N
Sbjct: 998 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055
Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 282
++EL + + T + E KEK+ L N + +
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL
Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175
Query: 343 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 398
R R+E +++ ++R + + +L M KR + E + I + L +K
Sbjct: 1176 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+LE++ + TV N L V ++ + L+ KV LE +L+
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1284
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)
Query: 60 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
+LE DL R +E+AEL++ L DM + L QE + S ++L + + +
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 556
Query: 112 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 171
++I +L G A E T+ KE T +K + + A K + +
Sbjct: 557 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 613
Query: 172 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 231
S+ + H Q + + + L + E +L + QIE + D + +E +Q Q
Sbjct: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 672
Query: 232 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
+ KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K
Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732
Query: 291 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 347
+ L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+
Sbjct: 733 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784
Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
+ + K K L+I + E++G + + L++ L ++ Q
Sbjct: 785 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833
Query: 408 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
V ++L +L E +++ A +Q ++ +K+ E + +
Sbjct: 834 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 66.2 bits (160), Expect = 6e-11
Identities = 74/389 (19%), Positives = 180/389 (46%), Gaps = 40/389 (10%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74
K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 75 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
++ + ++ ++++ E + L + +++ +IRE E+K++ +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 403
Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
K+ +K + + + E + + KI ++ R+E H Q I+ +
Sbjct: 404 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459
Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
E Q ++ Q + REQ E + ++H +E + ++ + K+ + +H +E + E
Sbjct: 460 E--QEEMWRQEEKIREQEEIWRQKEKMHEQE---KIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH--HAQS 311
+ R E + +E+ + + KI++ +++E+K+G+ M E Q
Sbjct: 515 EEKMW--RQEEKIREQEEKIREQE--EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
E I+ ++K+ ++K+ +E+ EE +IRE+E M +E + + K +
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLK 400
K E E+ R E + ++ ++++ +Q+ K
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656
Score = 62.4 bits (150), Expect = 8e-10
Identities = 90/475 (18%), Positives = 215/475 (45%), Gaps = 65/475 (13%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
L Y Q + + E E DL+ +L K +L+Q +A QK +D +
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 197
Query: 87 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 140
+ L L + + EL++K K+Q L LV ++ E+ KE K+
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 257
Query: 141 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 194
+ Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ 317
Query: 195 ALQAQLGEQTKLSREQIEGLI---------EDRRIHLEEIQVQHQRN-----------QN 234
+ ++ EQ + REQ E + E++ EE+ + + +
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377
Query: 235 KIKELTKNLHHTQELLYESTK----DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 290
KI+EL + +H +++ + K + ++ + + Q +E +++ + + ++ R Q K
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437
Query: 291 K---KEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL----SNMYQEQCISLEEELA 343
K +E+KI + + E + E + ++K+ +++++ M++++ I +EE
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 344 RIREEEGM--RREIFKDRTNKMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKL 399
R+EE M + E +++ KM ++ + + ++ E + + +I E E ++ +K+
Sbjct: 498 -WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM---MQEQEEKM 553
Query: 400 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+ E+ + + R + ++R+ + + + +++ + K++ E ++R
Sbjct: 554 GEQEEKMQEQEKMRRQEE------KIREQEEKIREQKEKIREQEEKIWEQEEKIR 602
Score = 60.8 bits (146), Expect = 2e-09
Identities = 91/445 (20%), Positives = 204/445 (45%), Gaps = 75/445 (16%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248
Query: 84 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 136
L ER +L +L +E D L K++Q++ A + E + + +
Sbjct: 249 RKL--ERAKLLLPQQQLQAEADHL-------GKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 137 HKVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKE------------------ 177
K+ ++ IQ E ++ E + + KI ++ R+E
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359
Query: 178 SSEHYQRDIQTLILQ----VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ--- 230
E R ++ ++ + + L+ ++ EQ K+ REQ E E+ +I +E + + +
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKM 418
Query: 231 --------RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW-----MLEKDN 277
+ KI+E K + +E ++E K ++ + Q +E+ W + E++
Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEE 476
Query: 278 LMSKIKQYRVQ--CKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQ 334
+ + ++ Q +K+E+K+ + E H Q E I+ ++K+ QE+K+ +EQ
Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWR----QEEKMHDQEEKIREQEEKMWRQEEKI----REQ 528
Query: 335 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394
+ E+ +IRE+E E+ +++ KMG++ + M ++ + RR+ ++ + I+
Sbjct: 529 EEKIREQEEKIREQE----EMMQEQEEKMGEQEEKMQEQEKM--RRQEEKIREQEEKIRE 582
Query: 395 LRQKLKDLEQMLYKATVNARANQDL 419
++K+++ E+ +++ R +++
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEM 607
Score = 48.5 bits (114), Expect = 1e-05
Identities = 68/356 (19%), Positives = 157/356 (44%), Gaps = 54/356 (15%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
+E + ++ M E E + +L +K+ ++ E + K + + + RE+E + Q+A Q
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 84 VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143
+E+E +R + + ++ +++KI+
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE--------------------------- 454
Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQ 203
E Q + ++ + KI ++ +KE H Q I+ +V + ++ +Q
Sbjct: 455 ------EEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263
+ REQ + ++ +E +++ Q + KI+E + + +E++ E + + +
Sbjct: 508 EEKIREQ------EEKMWRQEEKIREQ--EEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 264 NQNKEKSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 321
Q +EK E+ KI++ + + +++E+KI + E Q E ++ ++K+
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE----QEEKIREQEEMMQEQEEKM 615
Query: 322 -VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEA 376
QE+K+ QE+ + +EE R +EE+ +E+ R + +++Q + EA
Sbjct: 616 WEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEV---RLRQQEEKMQEHQEHLEA 666
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 65.5 bits (158), Expect = 1e-10
Identities = 96/465 (20%), Positives = 204/465 (43%), Gaps = 72/465 (15%)
Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 69
SPED H +E L ++ E + +L +K EL QH ++ Q E
Sbjct: 106 SPEDEQKASHQHQEAL----RRELEAQVHTIRILTCQKTELQMALYYSQHAVK----QLE 157
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
E +L L D E E L + + R +E+ K ++ L+L + T
Sbjct: 158 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 213
Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 181
+E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H
Sbjct: 214 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRN-----QNK 235
+++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + K
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 236 IKELTKNLHHTQELLYESTK------DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQC 289
I+E + + +E+++E + + + + E +++ M EK+ K+++
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMM 386
Query: 290 KKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEE 349
+KE+KI ++ MHE + + K +++ ++E++ QEQ + + +IRE+E
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQE 443
Query: 350 GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA 409
E +++ KM ++ + + E+ +I E E + ++ RQ+ K EQ
Sbjct: 444 ----EKIREQEKKMWRQEE------KIHEQEKIREEEKRQEQEEMWRQEEKIHEQE---- 489
Query: 410 TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
E+ + H+ + +++ + KV+ E ++R
Sbjct: 490 --------------EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/388 (20%), Positives = 179/388 (46%), Gaps = 42/388 (10%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQREEEIAELQKALSDM 82
+E + ++KM E E E K+ E K E + + E + ++EE+I E ++ + +
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 83 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142
+ ++++ E + +++ +IRE E+K++ Q E + +E H+ +
Sbjct: 450 EKKMWRQEEKI------HEQEKIRE-EEKRQEQ-----------EEMWRQEEKIHEQEEI 491
Query: 143 QKTIQAVGECEQS----ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198
+ + + E E+ E ++ + KI R + +E E R + + Q E +
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKI--REQEEKIREQEEKMWRQEEKIREQEEMWRE 549
Query: 199 Q--LGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQ---RNQNKIKELTKNLHHTQELLYE 252
+ + EQ K+ E+ ED+ EE I+ Q + R + KI+E + +E +++
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609
Query: 253 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312
+ + + Q +E+ +++ KI++ +++E+K+G+ M E E
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEE----KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 313 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTK 372
+++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K
Sbjct: 666 QEETMWR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 373 RYEALERRRILEVEGFKTDIKVLRQKLK 400
E E+ R E + ++ ++++ +Q+ K
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/333 (18%), Positives = 160/333 (48%), Gaps = 28/333 (8%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
++K+ E E + + KK+ +E Q K+ + +++E+E Q+ Q +++++
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150
E +++ + +++R +E + ++ + + E +E K+ ++ I+
Sbjct: 496 E---KMHEQEEKIRKQEEKVWRQEEKIR--------EQEEKIREQEEKMWRQEEKIREQE 544
Query: 151 ECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ 210
E + E + + KI + +E+++ + I+ +V + ++ EQ + +EQ
Sbjct: 545 EMWREEEKMHEQE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 211 IEGLI-EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEK 269
E + ++ +I +E ++Q Q + KI+E + + +E+ E + + + E +++
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQ--EEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMCEQE 660
Query: 270 SWMLEKDNLM----SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325
M E++ M KI++ + +++E+KI + +M E Q E + ++K+ +++
Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE----QEEKMWEQEEKMCEQE 716
Query: 326 KLSNMYQEQCISLEEEL----ARIREEEGMRRE 354
+ +E+ EE++ R+R++E +E
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/416 (22%), Positives = 194/416 (46%), Gaps = 55/416 (13%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
+++ AKL +E L+ + + +E + ++L +KLE + KL QQ + E
Sbjct: 281 KEKNAKL---QEKLQLVESEKSEIQLNVKELKRKLE--------RAKLLLPQQQLQAEAD 329
Query: 74 ELQKALSDMQVCL---FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTY 130
L K L + L +E E RL + + R+ E KIQ + ++
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKI-- 384
Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190
+E K+ ++ ++ E + + ++ + + R++ ++++ +
Sbjct: 385 --REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK--- 439
Query: 191 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHT 246
+ L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + +
Sbjct: 440 --IRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 247 QELLY---ESTKDFLQLRSENQNKEKSWML---EKDNLMSKIKQYRVQCKKKEDKIGKVL 300
+E ++ E + ++R E + +E+ M EK +I + + + ++E+KI K
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 301 PVM---HESHHAQSEYIKSLKDKLV-QEKKLSNMYQEQCISLEEELARIREEEGMRREIF 356
M E H Q E I+ ++K+ QE+K+ QE+ I +EE +IRE+E M +E
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE--QEEKIREQEE--KIREQEEMTQE-- 610
Query: 357 KDRTNKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQML 406
+ KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+
Sbjct: 611 --QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664
Score = 64.7 bits (156), Expect = 2e-10
Identities = 75/387 (19%), Positives = 178/387 (45%), Gaps = 41/387 (10%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 74
K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 75 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
++ + + ++++ E + L + +++ +IRE E+K++ +
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 464
Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
K+ +K + + + E + + KI ++ R+E H Q I+ +
Sbjct: 465 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520
Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
E Q ++ Q + REQ E + +IH +E +++ Q + K+ + +H +E + E
Sbjct: 521 E--QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ--EEKMWRQEEKMHDQEEKIREQ 576
Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313
+ R E + +E+ + + KI++ +++E+K+G+ M E E
Sbjct: 577 EEKVW--RQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632
Query: 314 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKR 373
+ ++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K
Sbjct: 633 EEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685
Query: 374 YEALERRRILEVEGFKTDIKVLRQKLK 400
E E+ R E + ++ ++++ +Q+ K
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Score = 48.9 bits (115), Expect = 9e-06
Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 55/288 (19%)
Query: 171 PSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR---------EQIEGLIED--RR 219
P E+K S +H + + L QV ++ ++T+L +Q+EG D R
Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227
Query: 220 IH------------LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK 267
+H L + Q ++ I+ELTK LY +T +L+ +N
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 287
Query: 268 EKSWML---EKDNLMSKIKQYR------------VQCKKKEDKIGKVLPVMHESHHAQSE 312
++ L EK + +K+ + Q + + D +GK L + AQ E
Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347
Query: 313 YIKSLKDKLVQEKKLSNMYQEQCI-----SLEEELARIRE--------EEGMRR--EIFK 357
L ++L Q+++ QE+ I ++E+ +IRE EE MRR E+
Sbjct: 348 E-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 406
Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQM 405
++ KM ++ ++M ++ E + R+ + E + I+ L +K+ + E++
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKI 453
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.5 bits (158), Expect = 1e-10
Identities = 94/437 (21%), Positives = 193/437 (44%), Gaps = 46/437 (10%)
Query: 19 KLHPSKELLEYYQKKMAECEA-------ENEDLLKKLELYKEACEGQHKLECDLQQREEE 71
KL ++ E Y+ ++ E E+ EN++ K L ++ EA + +H E + E+
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV-EKH 612
Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 131
EL+ +L Q L+ E+ VL+ + + ++RE +++K L +
Sbjct: 613 KTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 132 CKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKIS---------KRRPSRERKESSEH 181
++ K+ + Q ++++ E + + K + ++S K+ + E H
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-------IQVQHQRNQN 234
+Q+ + ++I + E + + K Q+E L+++R HL+E ++ +R++
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 235 KIKELTKNL---HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ--- 288
++++ + L Q +E TK + + ++ Q K E+ L ++ + Q
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 289 -CKKKEDKIGKVLPVMHESHHAQSEYIKSLKD-KLVQEKKL--SNMYQEQC--ISLEEEL 342
C + + +V +M + SE + +K V E KL N QEQ I +E+E
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 343 ARIREEEGMRREIFKDRTNKMGKR---LQIMTKRYEALERRRILEVEGFKTDIK----VL 395
++ EG ++EI + T K+ + + I+ + YE + + ++E K K L
Sbjct: 912 MILQMREGQKKEI-EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970
Query: 396 RQKLKDLEQMLYKATVN 412
++KL D E L K N
Sbjct: 971 KKKLLDQEAKLKKELEN 987
Score = 62.4 bits (150), Expect = 8e-10
Identities = 100/466 (21%), Positives = 192/466 (41%), Gaps = 66/466 (14%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE----LYKEACEGQ-HKLECD 64
L + EDRL +K L E +K + A + LL ++E YK+ E +L
Sbjct: 1622 LKALEDRLESESAAK-LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
Query: 65 LQQREEEIAELQKAL-----SDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA 119
LQ+RE E+ L++ L S + + + Y+E + + K + +
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKES 178
L +T +K +Q VG E E++ SS F+ + +R E E+
Sbjct: 1741 L---------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 179 SEHYQRDI-------------QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEI 225
+H + + + ++ + ++ + G+ +++ +E + +D + L+E
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 226 QVQHQRNQNKIKEL------TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLM 279
++ Q + KIKEL K +H + S + LQ + + K L ++N
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905
Query: 280 SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339
K K + VQ K+L M H+ L+ KL ++ ++ + L+
Sbjct: 1906 EKSKSHLVQ--------PKLLSNMEAQHN-------DLEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 340 EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQK 398
++L +R+E EI K ++ +R + + + E LE + ++ + L QK
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQ--EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 399 LKDLEQMLYKATVNARANQDLALL-CEVRDSNRRAHKIQGELKNLK 443
++LE M K T+N + LL ++N+ KI + +LK
Sbjct: 2009 EQELE-MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Score = 57.0 bits (136), Expect = 3e-08
Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 60/501 (11%)
Query: 2 ADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAE----NEDLLKKLELYKEACEG 57
+ S ES S + L +L + + EAE N D L K +L +
Sbjct: 87 SSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM 146
Query: 58 QHKLECDLQQREEEIAE---LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI 114
+ L + E + LQ+ +Q L Q ++ LR +E + + KK +
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 115 QN-----------LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE---QSESSAF 160
Q ++++ T + + P V +L+ Q + E + E+
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266
Query: 161 KADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLS--REQIEGLIEDR 218
+P + + + + +R L E +Q+ + T L+ +E ++ +++R
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326
Query: 219 RIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-- 276
LE+I+ H + K+ ++ + E L E K + ++ Q E M E++
Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-EQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 277 NLMSKIKQY-------RVQCKKKE----DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 325
L S+IKQ R Q +K E +++ K L ++ A+ + +K+ D+ Q K
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK-LKAEMDE--QIK 442
Query: 326 KLSNMYQEQCISLEEELARIREE---------EGMRREIFKDRTNKMGKRLQIMTKRYEA 376
+ +E+ ISL++EL+R+++E E ++ K ++ ++ Q +TK+ +
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 377 LERRRILEVEGFKTDIKVLRQKLKD--LEQMLYKATVNARANQDLALLCE--VRDSNRRA 432
ER F+ +KV +K + L+ K + A ++L L + + +S +
Sbjct: 503 RERE-------FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555
Query: 433 HKIQGELKNLKSKVFGLENEL 453
+Q E + ++++ LE+ L
Sbjct: 556 RDLQQEAETYRTRILELESSL 576
Score = 54.7 bits (130), Expect = 2e-07
Identities = 95/468 (20%), Positives = 197/468 (42%), Gaps = 64/468 (13%)
Query: 49 ELYKEACEGQHKLECDLQQREEEIAELQK----------------------------ALS 80
+L ++A E Q E LQ++E+E+AEL++ L+
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109
Query: 81 DMQVCLFQEREHVLRLYSENDRLR--IRELE-DKKKIQNLLALVGTDAGEVTYFCKEPPH 137
++Q L Q+ HV L + +L+ + +LE D K + E+ +E
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
Query: 138 KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEA-L 196
KV+ L ++ E QS S+ + K S S E K+ SE + + EA L
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
Query: 197 QAQLGEQTKLSREQIEGLI------EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250
+A+ E +S + ++ + R ++E + ++++ + L Q L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 251 YESTKDFLQLRSENQNKEKSW-------MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
S + E +N+ KS + EK+ L + + +KE I ++ +
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR--REIFKDRTN 361
E+ +A + + LK+K V+ LS + + L+ ++ +E + R+ + +
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
Query: 362 KMGKRLQIMTKRYEALERRRIL---EVEGFKTDIKVLRQK-----------LKDLE-QML 406
++ ++Q ++ + + L + +I +V+ + ++K +K+L+ Q+
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 407 YKATVNARANQDLALLCEVRD-SNRRAHKIQGELKNLKSKVFGLENEL 453
K+ ++ + LL E D N+R ++GE+++ KSK+ E+ L
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Score = 45.8 bits (107), Expect = 8e-05
Identities = 91/486 (18%), Positives = 195/486 (40%), Gaps = 69/486 (14%)
Query: 14 EDRLAKLHPSKELLEYYQ----KKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQR 68
E++LA+L LE + K++AE EA+ +D+ +L+ +K + + +LE +
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 69 EEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGE 127
E+++ L + +E+E ++ E + + ++ E KK+I+ L +
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
Query: 128 VTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRDI 186
+ +E K +K ++ V + + K + + +E + ++ E Q++
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 187 QTLILQVEALQAQ-LGEQTKLSR------EQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
Q +E QA G +SR EQIE L E R L ++ ++ N+ E
Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
+ +H Q + EK+ ++++KQ + +++++ K
Sbjct: 1058 LQEIHEIQ------------------------LQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR------------- 346
+ + E Q + L+++L Q+ N + L+ L ++
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 347 ----EEEGMRREIFKDRTNKMGKRLQIMTKRYEALE---RRRILEVEGFKTDIKVLRQKL 399
E M E K + +++ +L+ + +++L+ + +E + K L ++L
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 400 --------KDLEQMLYKAT---VNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 448
K E +L T +N +++ A+L + R K++ L V
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 449 LENELR 454
LE +LR
Sbjct: 1274 LEAQLR 1279
Score = 41.2 bits (95), Expect = 0.002
Identities = 69/313 (22%), Positives = 135/313 (43%), Gaps = 45/313 (14%)
Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQ 233
E++ + + DI++L+ + EALQ + G Q + + E+ E I + L E N
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSE-------NI 1352
Query: 234 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------------EKSWMLEKDNLMS 280
N + + + L + + +K L + QN K + EK L+
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 281 KIK--QYRVQCKKKEDKIGKVLPVMHESH-------HAQSEY------IKSLKDKLVQEK 325
+++ ++V KE KI + V S+ AQS + +K L+ +L +
Sbjct: 1413 QVQDLSFKVDTLSKE-KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 326 KLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEV 385
K + EQ L+EEL + + + +D +KM K+ + ++ + RI+E+
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS-QTARIMEL 1530
Query: 386 EGFKT----DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-RDSNRRAHKIQGELK 440
E T +I+ L + LK+ Q K + Q L E+ + + R + + ++
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQ--KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 441 NLKSKVFGLENEL 453
L+++V+ ++ EL
Sbjct: 1589 TLENQVYSMKAEL 1601
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 65.1 bits (157), Expect = 1e-10
Identities = 105/504 (20%), Positives = 215/504 (42%), Gaps = 88/504 (17%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENE-------DLLKKLELYKEACEGQHKLECDLQ 66
E ++A+ +E L + +AE E E E +L K+ E+ K A E L DL+
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE---LLSLDLK 1466
Query: 67 QREEEIAELQKALSDMQVC---------LFQEREHVLRLYSENDRLRIRELE-DKKKIQN 116
+R +E+ Q+ + +++ C QERE L + E +IRELE D++ +N
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE----QIRELEKDRETQRN 1522
Query: 117 LLA-----------LVGTDAGEV--------TYFC-----KEPPHKVTILQKTIQAVGEC 152
+L ++ + G+V T C +E HK+ QK I+ +
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 153 EQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIE 212
+++ A + R + +SS+ + + + +L E + ++ K REQIE
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIE 1640
Query: 213 GLIEDRR--------------IHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE------ 252
L + + E IQV + + K L ++L + L E
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 253 STKDFLQLRSEN---QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 309
+ + +Q R+E +K + LE L+ + K+ V+C+++ + + E
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH------IHELQELKDQ 1754
Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369
+ ++ L K+ + L + +++ + L+++L RE+ ++ + + + ++ + L
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814
Query: 370 MTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429
+ EAL++ + + +G + +K +K L+ L +A + + E++D
Sbjct: 1815 RDQELEALQQEQ-QQAQGQEERVK---EKADALQGALEQAHMTLKERHG-----ELQDHK 1865
Query: 430 RRAHKIQGELKNLKSKVFGLENEL 453
+A +++ EL +V LE L
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVL 1889
Score = 57.0 bits (136), Expect = 3e-08
Identities = 94/486 (19%), Positives = 212/486 (43%), Gaps = 54/486 (11%)
Query: 18 AKLHPSKELLEYYQKKMAECEAENEDLLKK---LELY-KEACEGQHKLECDLQQREEEIA 73
+++ +++ Q +AE E E L +K LE ++A E +L+ DL+ +EE
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690
Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAG-EVTYFC 132
E+QK LS+ + Q+ +L + + +E + +Q ALV A EV
Sbjct: 691 EIQKKLSESR---HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 133 KEPPHKVTILQKTIQAVGECEQS-ESSAFKADPKISKRRPSRERKE--------SSEHYQ 183
E + L + +Q + ++ ESS F+A + S ++ + E + E Q
Sbjct: 748 VERDRQD--LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL--TK 241
+++ L L+++ ++Q ++ + Q+ ++ + LE+ + H++ N+++E +
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865
Query: 242 NLHHTQELL-----YESTKDFLQLRSENQNKEKSWML-----EKDNLMSKIKQYRVQCKK 291
H QEL E K L++R + Q E + E+ S + Q +++ +K
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925
Query: 292 KEDKIGKVLPVMHESHHAQSEYIKSLKDKL----VQEKKLSNMYQEQCISLEEELARIRE 347
+ + + L + S+ ++ L+ + ++E++ + + Q Q + EL
Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL-------- 399
+ ++ ++ + + + K+ E L+ + + + + + + +++KL
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 400 --KDLEQMLYKATVNARANQDLALLCEVRDSNRR---------AHKIQGELKNLKSKVFG 448
K+LE+ T++ + L+ + DS R+ + QGE K L +++
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 449 LENELR 454
L E++
Sbjct: 1106 LRQEVK 1111
Score = 47.4 bits (111), Expect = 3e-05
Identities = 87/447 (19%), Positives = 187/447 (41%), Gaps = 53/447 (11%)
Query: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQH 59
M + E PS R + H +L+ ++K EC+ E+ L++L + ++ +G H
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEH--MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH 1763
Query: 60 KLECD----LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQ 115
+ + L QRE+EI LQ+ L + + + L+ S +L + ++ Q
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAR------EQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 116 NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER 175
L AL + + + +K G EQ+ + + ++ ++
Sbjct: 1818 ELEALQQEQQ-------QAQGQEERVKEKADALQGALEQAHMTLKERHGEL------QDH 1864
Query: 176 KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNK 235
KE + + ++ +V+AL+ LG+ SREQ + L+ + ++ Q Q ++ +
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ----QQCAEQAQEHEVE 1920
Query: 236 IKELTKNLHHTQELLYESTKDFLQLRSENQ---NKEKSWMLEKDNLMSKIKQYRVQCKKK 292
+ L + Q +L E ++ LR+E+Q ++E++ + L + + + K
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 293 EDKIGKVLPVMH----------------ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336
E + + + ++H Q E +++ +Q++ L YQE
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--RYQEDVQ 2038
Query: 337 SLEEELARIREEEGMRREIFKDRTNKMGKRLQ--IMTKRYEALERRRILEVEGFKTDIKV 394
L++ LA+ EE ++E + + +R+Q ++ ++ + R E+ G ++
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE 2098
Query: 395 LRQKLKDLEQMLYKATVNARANQDLAL 421
L+ L EQ + + + N AL
Sbjct: 2099 LQLTLAQKEQEILELRETQQRNNLEAL 2125
Score = 46.6 bits (109), Expect = 5e-05
Identities = 107/523 (20%), Positives = 214/523 (40%), Gaps = 83/523 (15%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQH-----------KLE 62
E++ +LH + E Q+ + EA+ + L +L +EA E H ++
Sbjct: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
Query: 63 CDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI-----QNL 117
L + E+ IAEL + + ++ + R ++L + N+ L + ++ +++ +N
Sbjct: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
Query: 118 LALVGTDAGEVTY------FCKEPPHKVTILQKTIQAVGECEQSESSA--FKADPK-ISK 168
+A E + + + +K + +++E + +AD + I +
Sbjct: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQE 687
Query: 169 RRPSRERKESSEHYQRDIQTLIL---------QVEALQAQLGEQTKLSRE------QIEG 213
+ ++K S +Q++ T L Q E L + E+ L RE +++
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 214 LIEDRRIHLEEIQ------------VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ-- 259
+ DR+ E++Q + + QN + E+TK Q K+ +Q
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807
Query: 260 ---LRSENQNKEKSWMLEKDNLMSKIKQYR-------VQCKKKEDKIGKVLPVMHESHHA 309
L+ E + E+D ++ Q Q K +K L E +
Sbjct: 808 VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
Query: 310 --QSEYIKSL----KDKLVQEKKLSNMYQE-QCISLEEELARIREEEG---MRREIFKDR 359
Q E K+L ++K+ E +L E + I + E R + E M+ E K+R
Sbjct: 868 WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927
Query: 360 TNKMGKRLQIMTKRYEA---LER-RRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNA 413
+ + LQ + +A LER R+ ++V+ K +L+ +L++ ++ L +A
Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 414 RANQDLALLCEVRDS-NRRAHKIQGELKNLKSKVFGLENELRL 455
R DLA L E S + +Q ++++LKS++ ++ RL
Sbjct: 988 R--DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Score = 42.7 bits (99), Expect = 7e-04
Identities = 71/328 (21%), Positives = 135/328 (41%), Gaps = 32/328 (9%)
Query: 29 YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 88
++Q+++A+ E +K+EL E Q ++E QREEE + + AL MQ+
Sbjct: 868 WHQQELAKALESLER--EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL---- 921
Query: 89 EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 148
E ++ R+ LE + Q LA DA + ++ + ++
Sbjct: 922 ----------ETEKERVSLLETLLQTQKELA----DASQQLERLRQDMKVQKLKEQETTG 967
Query: 149 VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 208
+ + + E+ + R +E S +D L QVE L++QL Q R
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL---QLRSENQ 265
+ + E R E ++Q + + K + Q LL D + +L + Q
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 266 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKI----GKVLPVMHESHHAQSEYIKSLKDKL 321
+ +++ E+ L ++++ R + K+KE ++L + SH + + SL
Sbjct: 1088 DMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL---W 1143
Query: 322 VQEKKLSNMYQEQCISLEEELARIREEE 349
QE K + + Q + S E +L + E+
Sbjct: 1144 AQEAKAAQL-QLRLRSTESQLEALAAEQ 1170
Score = 41.6 bits (96), Expect = 0.002
Identities = 101/515 (19%), Positives = 209/515 (40%), Gaps = 93/515 (18%)
Query: 10 LPSPEDRLAKLHPSKEL----LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
L E RL L + + L ++ M E + E ++L ++EL ++ + + E D
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK---EADF 1117
Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
+E A+L + L + Q R + ++ +L++R + +++ L A
Sbjct: 1118 LAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA--EQQP 1172
Query: 126 GEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185
G + + LQ+ + +V E S + P + P + S ++R
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL--FKRG 1230
Query: 186 IQTLILQVEALQAQLG---------EQTK-LSREQIEGL--------IEDRRIH--LEEI 225
L EA+ + L +QT+ + R+Q++ L E ++H L+++
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 226 QVQHQRNQ----------NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275
Q Q +NQ N ++ LH T L + R E Q + + K
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 276 DNLMSKIKQYR---VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 332
+NL ++++ + V+ + + G ++ E +K +++ E++ + Q
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 333 E-------QCISLEEELARI------REEE-----GMRREIFKDR-------------TN 361
E Q +L+E LA + REEE G +E+ K R
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 362 KMGKRLQIMTKRYEALER-RRILE-----VEGFKTDIKVLRQKLKDLEQMLYKATVNARA 415
K + + + ++ + LE+ R +LE V+ + + V R+++++LE+ + N
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLE 1525
Query: 416 NQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
+Q L E+ ++ +G++++LK ++ LE
Sbjct: 1526 HQ----LLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Score = 35.0 bits (79), Expect = 0.14
Identities = 87/464 (18%), Positives = 173/464 (37%), Gaps = 75/464 (16%)
Query: 38 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97
E ++LL +LE ++ CE ++ L+ E+ + KAL RE V +L
Sbjct: 93 EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL----------REDVEKLT 142
Query: 98 SE----NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPP----HKVTILQKT---- 145
+ D L +E + + + + + + G + +E H + + T
Sbjct: 143 VDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDL 202
Query: 146 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 205
++ E + S +++ SRE S R+ L+L + Q E +
Sbjct: 203 MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHE 262
Query: 206 LSREQIE---------GLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKD 256
S+E I+ ++DR L + Q Q+ +++ K L T E+L + +
Sbjct: 263 RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322
Query: 257 FLQLRSENQNKEKSWMLEKDNLMSKIKQYRV-------QCKKKEDKI------------- 296
++ + + L ++ I Q V Q E+ +
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ 382
Query: 297 --GKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGM--- 351
K L ++ + + ++ L+ +L ++ N+ Q+Q EEE +R+
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411
R+ +T + + ++K E L++ R + LRQ+L+ LEQ ++
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAR-----------EELRQQLEVLEQEAWRL-- 489
Query: 412 NARANQDLAL-----LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
R N +L L + + H E + L+ + GLE
Sbjct: 490 -RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/346 (18%), Positives = 161/346 (46%), Gaps = 26/346 (7%)
Query: 40 ENEDLLKKLELYKEACEGQ-HKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYS 98
E E +++ E EGQ + E ++++E ++ E + + + + Q RE ++
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG---QVREQEGQVRE 168
Query: 99 ENDRLRIRE---LEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS 155
+ ++R +E E + +++ +G G++ ++ + +QK + +GE E+
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 156 ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI 215
+ E++E + + +Q Q+ + Q+ EQ + REQ E ++
Sbjct: 229 MRK---------QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 216 EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 275
+ + +E Q Q Q ++E + + +E + E + + + E K++ M E+
Sbjct: 280 KQKEQTEQEEQTGEQEEQ--MREQEEQMREQEEQMREQEEQMRE-QEEQMGKQEEQMWEQ 336
Query: 276 DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
M + K+ Q K+E+++G+ E Q E ++ ++++ ++++ +EQ
Sbjct: 337 KEQMWEQKE---QMWKQEEQMGE----QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 336 ISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRR 381
EE++ +E+ G ++E +++ +MG++ + M K+ E + ++
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 37.4 bits (85), Expect = 0.028
Identities = 40/213 (18%), Positives = 99/213 (46%), Gaps = 11/213 (5%)
Query: 169 RRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIEGLIEDRRIHLEEIQV 227
R + E KE + Q ++Q + + +Q + E + KL ++I L ++ ++ +E QV
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIP-LPQEGQVREQEGQV 61
Query: 228 QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287
+ Q Q ++E + + + E + E Q +E+ + + ++++
Sbjct: 62 REQEGQ--VREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQE--GQVREQEG 115
Query: 288 QCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
Q +++E ++ + + E E ++++ Q ++ +EQ + E+ ++RE
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175
Query: 348 EEGMRRE---IFKDRTNKMGKRLQIMTKRYEAL 377
+EG RE +++ +MG++ M ++ E +
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.9 bits (154), Expect = 3e-10
Identities = 101/479 (21%), Positives = 206/479 (43%), Gaps = 67/479 (13%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
+ ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132
EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y
Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 133 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
+ ++ LQKT+ Q E + E + + + S +R E E +
Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873
Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294
+ ES +L EN+ K ++ +++L+S K +Q +K
Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 295 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
++ K+ ++H+ K L+ KL K S +E+ I+ E AR+ E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 988
Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393
+++ ++ L+ + K YEAL++R+ E E +T +
Sbjct: 989 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040
Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
+L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ +
Sbjct: 1041 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Score = 63.5 bits (153), Expect = 4e-10
Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
+E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139
+R+ + L EN L E+ K+ + L L G + ++ T E P H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454
Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175
L Q + V E + S KI K +R
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231
K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573
Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270
+Q + K++ ++L+ES K+ Q++ E ++ KEK
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
LEK+N L KI ++ C+K E + + + + LK L K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685
Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
+ Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733
Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
E K +++L+ K E++ NQ L E +SN++ +++ EL++L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791
Query: 445 KVFGLENEL 453
+ L+ L
Sbjct: 792 ENQTLQKNL 800
Score = 63.5 bits (153), Expect = 4e-10
Identities = 97/449 (21%), Positives = 197/449 (43%), Gaps = 57/449 (12%)
Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
E + L EN L + KK + + K ++ L+K
Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694
Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
+ E E E K + + ++ + E+ E + + + L +E L+A ++T
Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751
Query: 205 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258
+ +GL IE++R+ LE + Q+ ++++++L + L E L S+K
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318
QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+
Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 319 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365
+ K +Y+E C+ L+E EL + I+ +R ++ + +T +M
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 366 RLQIMTKRYE--ALERRRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNARANQDLAL 421
L+ +T E L + R+L E D K+L KL + K ++ + + AL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL----ESTLKKSLEIKEEKIAAL 979
Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFGLE 450
+ +S +++ ELK +K L+
Sbjct: 980 EARLEESTNYNQQLRQELKTVKKNYEALK 1008
Score = 47.0 bits (110), Expect = 4e-05
Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)
Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
E+ E ++ + E EN+ L K +E + + + + E+E L K + ++
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
+ QE++ + + QNL K+ + L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540
Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
TI+ + E + + + + + + S R+ S Q + + +E L E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596
Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650
Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321
EK LE++N S++++ + KK D K L ES ++ + +L
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707
Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
V+ K ++M Q +EL +E+ E+ K + K +RL++ + + +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766
Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438
R +E I+ L +L+DLE NQ L L E++ S++R +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816
Query: 439 LKNLKSKVFGLENE 452
K+L+ + LE +
Sbjct: 817 NKSLEQETSQLEKD 830
Score = 41.2 bits (95), Expect = 0.002
Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)
Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
E L S D L K H ELL Q +E E L+ K K A + DL
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1198
Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
+ R ++ + + L D++ L E+E +L LE+K T A
Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1237
Query: 126 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182
E C E H + L K + + + + + + K+ + R E + E Y
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296
Query: 183 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+
Sbjct: 1297 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1339
Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302
L +N + + +E+ + K+ + R Q +K E+KI
Sbjct: 1340 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383
Query: 303 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
S + +I KL++ KK N +++ ++L
Sbjct: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1420
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 63.9 bits (154), Expect = 3e-10
Identities = 97/448 (21%), Positives = 197/448 (43%), Gaps = 56/448 (12%)
Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
E + L EN L + KK + + K ++ L+K
Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694
Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
+ E E E K + + ++ + E+ E + + + L +E L+A ++T
Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751
Query: 205 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 258
+ +GL IE++R+ LE + Q+ ++++++L + L E L S+K
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 318
QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+
Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 319 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 365
+ K +Y+E C+ L+E EL + I+ +R ++ + +T +M
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 366 RLQIMTKRYE--ALERRRILEVEGFKTD-IKVLRQKLKDLEQMLYKATVNARANQDLALL 422
L+ +T E L + R+L E D K+L KL + K ++ + + AL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL----ESTLKKSLEIKEEKIAALE 979
Query: 423 CEVRDSNRRAHKIQGELKNLKSKVFGLE 450
+ +S +++ ELK +K L+
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALK 1007
Score = 63.5 bits (153), Expect = 4e-10
Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 86
+E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 139
+R+ + L EN L E+ K+ + L L G + ++ T E P H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454
Query: 140 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 175
L Q + V E + S KI K +R
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 176 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 231
K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573
Query: 232 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 270
+Q + K++ ++L+ES K+ Q++ E ++ KEK
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 271 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
LEK+N L KI ++ C+K E + + + + LK L K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685
Query: 328 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
+ Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733
Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
E K +++L+ K E++ NQ L E +SN++ +++ EL++L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791
Query: 445 KVFGLENEL 453
+ L+ L
Sbjct: 792 ENQTLQKNL 800
Score = 63.2 bits (152), Expect = 5e-10
Identities = 102/479 (21%), Positives = 207/479 (43%), Gaps = 68/479 (14%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
+ ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 132
EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y
Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 133 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
+ ++ LQKT+ Q E + E + + + S +R E E +
Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873
Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 294
+ ES +L EN+ K ++ +++L+S K +Q +K
Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 295 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
++ K+ ++H+ Y K L+ KL K S +E+ I+ E AR+ E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 987
Query: 351 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 393
+++ ++ L+ + K YEAL++R+ E E +T +
Sbjct: 988 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
+L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ +
Sbjct: 1040 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
Score = 47.0 bits (110), Expect = 4e-05
Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)
Query: 25 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 84
E+ E ++ + E EN+ L K +E + + + + E+E L K + ++
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 85 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 144
+ QE++ + + QNL K+ + L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540
Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 204
TI+ + E + + + + + + S R+ S Q + + +E L E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596
Query: 205 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650
Query: 265 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 321
EK LE++N S++++ + KK D K L ES ++ + +L
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707
Query: 322 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
V+ K ++M Q +EL +E+ E+ K + K +RL++ + + +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766
Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 438
R +E I+ L +L+DLE NQ L L E++ S++R +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816
Query: 439 LKNLKSKVFGLENE 452
K+L+ + LE +
Sbjct: 817 NKSLEQETSQLEKD 830
Score = 41.2 bits (95), Expect = 0.002
Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)
Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
E L S D L K H ELL Q +E E L+ K K A + DL
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1197
Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
+ R ++ + + L D++ L E+E +L LE+K T A
Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1236
Query: 126 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 182
E C E H + L K + + + + + + K+ + R E + E Y
Sbjct: 1237 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1295
Query: 183 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+
Sbjct: 1296 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1338
Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 302
L +N + + +E+ + K+ + R Q +K E+KI
Sbjct: 1339 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1382
Query: 303 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
S + +I KL++ KK N +++ ++L
Sbjct: 1383 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1419
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 63.5 bits (153), Expect = 4e-10
Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)
Query: 23 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71
S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3275
Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128
E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3334
Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181
PP L K +Q E + S E+ +K D ++++ ++R+ +
Sbjct: 3335 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390
Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K
Sbjct: 3391 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3445
Query: 242 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++
Sbjct: 3446 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3500
Query: 302 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355
M+ + ++ ++ KL KL + Q+ L+ E A + ++ I
Sbjct: 3501 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3559
Query: 356 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409
+ T + G+ +++ +L R + + I L ++ DL M+ K
Sbjct: 3560 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619
Query: 410 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
++N AN + + E NR +Q LK +++V+ L+ E
Sbjct: 3620 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679
Query: 453 LR 454
LR
Sbjct: 3680 LR 3681
Score = 57.0 bits (136), Expect = 3e-08
Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79
+E QK+ + D+++++E + Q + E D +Q ++E I + +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460
Query: 80 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122
+M+ E E+ LR YS D++++ +L+D K+K++ L L+
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520
Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173
+ + ++ +++ +Q+ Q + E E + A K+ D K S
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222
RKE ++ ++ +++E L+ + E E +E R L
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281
E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691
Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
Q ++ K +D ++ K + ++ + + + +++ ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383
+ L +E+ L+E+ A++ E I KD + L+I T + R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804
Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416
++ K+ +I++L ++ +DL+Q + A N N
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
++ A L +V+D + K + EL+ KSK+ L EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902
Score = 55.1 bits (131), Expect = 1e-07
Identities = 81/458 (17%), Positives = 193/458 (42%), Gaps = 38/458 (8%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69
+ + KL +++ +Q E E L L+ + C + +L+ D+Q+R
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
EEI +L+ + +++ L + ++ DR +E K ++ +L + + +
Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKV---EDRKHFGAVEAKPEL-SLEVQLQAERDAID 2199
Query: 130 YFCKEPPHKVTILQKTIQAVG---ECEQSESSAFKADPKISKRRPS---RERKESSEHYQ 183
KE +T L++ ++ E + E +I K+ + +E ++ ++ ++
Sbjct: 2200 RKEKE----ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN- 242
D++ L L ++ A + + + +I+++ + ++++ Q + Q ++K T N
Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
Query: 243 -LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
+ EL+ + L S+ + K N +I+Q +K + ++ +
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQELANIGQ 2368
Query: 302 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD--- 358
+ H+ SE SLK +L ++ + ++LE+++ EE + + K+
Sbjct: 2369 KTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
Query: 359 RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQD 418
+ N++ + L + + E++E+ + + I L + +LE +L + + + NQ
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT 2481
Query: 419 LALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
E + ++ L L+S V + EL C
Sbjct: 2482 YFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2518
Score = 52.8 bits (125), Expect = 7e-07
Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74
+L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333
Query: 75 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113
L K L ++Q + Q+ + + + E + +E + ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157
I+ L+ V + V +E K+ L+ + Q + + +Q
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197
A + K R E + + Y +Q Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513
Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251
+LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
E + R E + K + +++ Y+++ + E + VL M ES A+
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370
E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425
+ L + + ILE+ KLKDL+Q L + Q L E+
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454
R + ++ E++ L+ K LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Score = 51.6 bits (122), Expect = 1e-06
Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
+ LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M
Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3143
Query: 84 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135
++R L+ ++++ + EL + K +++ L E+ F K+
Sbjct: 3144 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
Query: 136 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191
+V +L T+ E ++S + + + +K S ER KE E + +++ L
Sbjct: 3200 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257
Query: 192 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244
Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
+EL QL+S + + L ++L+ +++ K+ E+K +++ +++
Sbjct: 3318 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3364
Query: 305 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351
E+ + + +++ KD+ V K L + + S E+L R EE+
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422
Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
R++++K + G+RLQ + + ++ E LE E + ++L Q L +
Sbjct: 3423 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3466
Score = 44.7 bits (104), Expect = 2e-04
Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)
Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71
PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E
Sbjct: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399
Query: 72 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119
+ ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459
Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156
L T+ + +LQ+ I+ GE ++S
Sbjct: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517
Query: 157 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208
+S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S
Sbjct: 3518 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3577
Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
G + +R + Q+ I +LT+ + + ++ + + R ++
Sbjct: 3578 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
Query: 269 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
S + +L + +KE + L + A++E K LK +L + L
Sbjct: 3632 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3686
Query: 329 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382
Q +S + E ++ G +R E F+ K L ++ ++ E +
Sbjct: 3687 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3741
Query: 383 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440
+ + TD++V+ + K + V+ ++ L+ RR H++ G +
Sbjct: 3742 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3794
Query: 441 NLKSKVFGL 449
N+ FGL
Sbjct: 3795 NINRDGFGL 3803
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)
Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
L+ P + E L PS+ + QK++ ++E DL ++E + + D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 65 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119
Q RE E KAL + + +F + E + L E ++ +E D+ K +LL
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 120 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175
L + E +YF + ++L + +CE + + IS+ ++
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 176 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214
+ + +Q ++ TL+ +V LQ +L G+QT L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 215 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271
I + +LE+I V H+ + +++L K Q ES L QL+ QN E
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365
Query: 272 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316
+ L + + + V D + V+ ES ++ Y S
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 317 --LKDKLVQEKKLSNMYQEQCISLEEELARI 345
+K++ K L YQEQ LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447
Score = 40.8 bits (94), Expect = 0.003
Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)
Query: 58 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117
+ +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2646
Query: 118 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172
L+ G + + K P V +L+ T + E+S E A +A+ ++ +
Sbjct: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2705
Query: 173 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229
KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2760
Query: 230 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281
+ + L L + + T L++ S NQ + +L K+ NL S+
Sbjct: 2761 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2814
Query: 282 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
I Q+ + +K ++ + M H +++E +K VQ + +E+C
Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2868
Query: 336 ISLEEELARIREEEG 350
+L+ + +R +EG
Sbjct: 2869 GTLKAVIQCLRSKEG 2883
Score = 36.2 bits (82), Expect = 0.063
Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)
Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243
+E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264
+ E+ ++FL+L ++
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303
Q K++ + ++ L KIK Y ++ KK + K ++ +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
+ + + LKDKL KL QEQ + +E+ ++ + K + +
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390
Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421
+ ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q +
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446
Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454
+++ R H Q ++ +K++ G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476
Score = 30.0 bits (66), Expect = 4.5
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)
Query: 42 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
E + K EL YKE E KL+ +L +E + LQK LS Q R+H L
Sbjct: 2697 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2743
Query: 100 NDRLRIRELEDKKKIQ 115
++L I E ED+ ++Q
Sbjct: 2744 KEKLSILEKEDETEVQ 2759
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 63.5 bits (153), Expect = 4e-10
Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)
Query: 23 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 71
S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3267
Query: 72 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 128
E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3326
Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 181
PP L K +Q E + S E+ +K D ++++ ++R+ +
Sbjct: 3327 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382
Query: 182 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K
Sbjct: 3383 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3437
Query: 242 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 301
QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++
Sbjct: 3438 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3492
Query: 302 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 355
M+ + ++ ++ KL KL + Q+ L+ E A + ++ I
Sbjct: 3493 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3551
Query: 356 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 409
+ T + G+ +++ +L R + + I L ++ DL M+ K
Sbjct: 3552 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611
Query: 410 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
++N AN + + E NR +Q LK +++V+ L+ E
Sbjct: 3612 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3671
Query: 453 LR 454
LR
Sbjct: 3672 LR 3673
Score = 57.4 bits (137), Expect = 3e-08
Identities = 86/465 (18%), Positives = 197/465 (42%), Gaps = 60/465 (12%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 69
+ + KL +++ +Q E E L L+ + C + +L+ D+Q+R
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
Query: 70 EEIAELQKALSDM-QVCLFQEREHV------------LRLYSENDRLRIRELEDKKKIQN 116
EEI +L+ + ++ Q L ++R+H ++L +E D + +E K+I N
Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----KEITN 2199
Query: 117 LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERK 176
L ++ F +E +K +Q+ + E ++ ES+ +E +
Sbjct: 2200 L-------EEQLEQFREELENKNEEVQQLHMQL-EIQKKESTT-----------RLQELE 2240
Query: 177 ESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKI 236
+ ++ ++ D++ L L ++ A + + + +I+++ + ++++ Q + Q ++
Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300
Query: 237 KELTKN--LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKED 294
K T N + EL+ + L S+ + K N +I+Q +K +
Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQ 2353
Query: 295 KIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354
++ + + H+ SE SLK +L ++ + ++LE+++ EE +
Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKN 2406
Query: 355 IFKD---RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 411
+ K+ + N++ + L + + E++E+ + + I L + +LE +L + +
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466
Query: 412 NARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
+ NQ E + ++ L L+S V + EL C
Sbjct: 2467 KSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2510
Score = 57.0 bits (136), Expect = 3e-08
Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)
Query: 27 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 79
+E QK+ + D+++++E + Q + E D +Q ++E I + +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460
Query: 80 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 122
+M+ E E+ LR YS D++++ +L+D K+K++ L L+
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520
Query: 123 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 173
+ + ++ +++ +Q+ Q + E E + A K+ D K S
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 222
RKE ++ ++ +++E L+ + E E +E R L
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 223 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 281
E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691
Query: 282 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
Q ++ K +D ++ K + ++ + + + +++ ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 383
+ L +E+ L+E+ A++ E I KD + L+I T + R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804
Query: 384 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 416
++ K+ +I++L ++ +DL+Q + A N N
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 417 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
++ A L +V+D + K + EL+ KSK+ L EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902
Score = 52.8 bits (125), Expect = 7e-07
Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 74
+L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333
Query: 75 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 113
L K L ++Q + Q+ + + + E + +E + ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 114 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 157
I+ L+ V + V +E K+ L+ + Q + + +Q
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 158 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 197
A + K R E + + Y +Q Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513
Query: 198 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 251
+LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 252 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
E + R E + K + +++ Y+++ + E + VL M ES A+
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 370
E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 371 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 425
+ L + + ILE+ KLKDL+Q L + Q L E+
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 426 -RDSNRRAHKIQGELKNLKSKVFGLENELR 454
R + ++ E++ L+ K LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Score = 51.6 bits (122), Expect = 1e-06
Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
+ LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M
Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3135
Query: 84 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 135
++R L+ ++++ + EL + K +++ L E+ F K+
Sbjct: 3136 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191
Query: 136 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 191
+V +L T+ E ++S + + + +K S ER KE E + +++ L
Sbjct: 3192 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3249
Query: 192 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 244
Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
+EL QL+S + + L ++L+ +++ K+ E+K +++ +++
Sbjct: 3310 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3356
Query: 305 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 351
E+ + + +++ KD+ V K L + + S E+L R EE+
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3414
Query: 352 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
R++++K + G+RLQ + + ++ E LE E + ++L Q L +
Sbjct: 3415 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3458
Score = 44.7 bits (104), Expect = 2e-04
Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)
Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 71
PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E
Sbjct: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391
Query: 72 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 119
+ ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3451
Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 156
L T+ + +LQ+ I+ GE ++S
Sbjct: 3452 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509
Query: 157 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 208
+S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S
Sbjct: 3510 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3569
Query: 209 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
G + +R + Q+ I +LT+ + + ++ + + R ++
Sbjct: 3570 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623
Query: 269 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 328
S + +L + +KE + L + A++E K LK +L + L
Sbjct: 3624 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3678
Query: 329 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 382
Q +S + E ++ G +R E F+ K L ++ ++ E +
Sbjct: 3679 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3733
Query: 383 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 440
+ + TD++V+ + K + V+ ++ L+ RR H++ G +
Sbjct: 3734 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3786
Query: 441 NLKSKVFGL 449
N+ FGL
Sbjct: 3787 NINRDGFGL 3795
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)
Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
L+ P + E L PS+ + QK++ ++E DL ++E + + D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 65 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 119
Q RE E KAL + + +F + E + L E ++ +E D+ K +LL
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 120 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 175
L + E +YF + ++L + +CE + + IS+ ++
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 176 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 214
+ + +Q ++ TL+ +V LQ +L G+QT L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 215 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 271
I + +LE+I V H+ + +++L K Q ES L QL+ QN E
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365
Query: 272 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 316
+ L + + + V D + V+ ES ++ Y S
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 317 --LKDKLVQEKKLSNMYQEQCISLEEELARI 345
+K++ K L YQEQ LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447
Score = 40.8 bits (94), Expect = 0.003
Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)
Query: 58 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 117
+ +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2638
Query: 118 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 172
L+ G + + K P V +L+ T + E+S E A +A+ ++ +
Sbjct: 2639 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2697
Query: 173 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 229
KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2752
Query: 230 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 281
+ + L L + + T L++ S NQ + +L K+ NL S+
Sbjct: 2753 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2806
Query: 282 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 335
I Q+ + +K ++ + M H +++E +K VQ + +E+C
Sbjct: 2807 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2860
Query: 336 ISLEEELARIREEEG 350
+L+ + +R +EG
Sbjct: 2861 GTLKAVIQCLRSKEG 2875
Score = 36.2 bits (82), Expect = 0.063
Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)
Query: 193 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 243
+E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 244 HHTQELLYESTKDFLQLRSEN--------------------------------------- 264
+ E+ ++FL+L ++
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 265 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 303
Q K++ + ++ L KIK Y ++ KK + K ++ +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
+ + + LKDKL KL QEQ + +E+ ++ + K + +
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390
Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 421
+ ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q +
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446
Query: 422 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 454
+++ R H Q ++ +K++ G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476
Score = 30.0 bits (66), Expect = 4.5
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)
Query: 42 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
E + K EL YKE E KL+ +L +E + LQK LS Q R+H L
Sbjct: 2689 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2735
Query: 100 NDRLRIRELEDKKKIQ 115
++L I E ED+ ++Q
Sbjct: 2736 KEKLSILEKEDETEVQ 2751
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 63.5 bits (153), Expect = 4e-10
Identities = 93/456 (20%), Positives = 205/456 (44%), Gaps = 61/456 (13%)
Query: 20 LHPSKELLEYYQKKMAECEAENEDLLKKLEL-YKEACEGQHKLECDLQQREEEIAELQKA 78
L + L+ K++ E E+ LK KE E ++L +L ++E EI+ +QK
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 79 LSDMQVCLFQEREHVLRLYSENDRLRIREL--------------EDKKKIQNLLALVGTD 124
L + L + + +Y + ++ I+++ E +K + L + +
Sbjct: 1514 LEAINDKL---QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 125 AGEVTYFCKEPPHKVTIL---QKTIQAVGECEQSESSAFKADPK--ISKRRPSRERKESS 179
E+T +E ++ I+ ++ ++ V E Q E K + K ++K + S+E++
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE--- 1627
Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
YQ T + + + ++ E ++ E ++++LE I+ ++ R L
Sbjct: 1628 --YQFLKMTAVNETQEKMCEI--------EHLKEQFETQKLNLENIETENIR-------L 1670
Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
T+ LH E + TK+ R + ++ E++ +E+D L +++ + +K+++
Sbjct: 1671 TQILHENLEEMRSVTKE----RDDLRSVEETLKVERDQLKENLRETITRDLEKQEE---- 1722
Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEK--KLSNMYQE---QCISLEEELARIREEEGMRRE 354
L ++H E I L+ +V EK ++SNM ++ +L+ + +I+EE +
Sbjct: 1723 LKIVHMHLKEHQETIDKLRG-IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781
Query: 355 IFKDRTNKMGKRLQIMTKRYEALER-RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVN- 412
K++ + K I++++ + L ++ LE K K+ K + + + K VN
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841
Query: 413 --ARANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446
+ ++ L +++D + K++ E NL K+
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Score = 60.8 bits (146), Expect = 2e-09
Identities = 102/495 (20%), Positives = 210/495 (42%), Gaps = 76/495 (15%)
Query: 5 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 64
L+ T + ++++ ++ KE E + + E EN L + L E K D
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 65 LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALV 121
L+ EE + + L + RE + R + + L+I + E ++ I L +V
Sbjct: 1691 LRSVEETLKVERDQLKE------NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 122 GTDAGEVTYFCKEPPHKVTILQ-KTIQAVGECEQSESSAFKADPKISKRRP-SRERKESS 179
E++ K+ H L+ + ++ E + + I K R E+ +
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804
Query: 180 EHYQRD-------IQTLILQVEALQAQL--------GEQTKLSR-EQIEGLIEDRRIHLE 223
+ Q+D +Q I +++A + QL Q K+S EQ++ I+D+ + L
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1864
Query: 224 EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL----- 278
+++++ N N ++L +NL E K ++ R + E++ LE+D L
Sbjct: 1865 KLEIE---NLNLAQKLHENL--------EEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 279 ---------MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL-KDKLVQEKKLS 328
++K R+ K+ ++ + K+ + E S+ K L K K +KK+
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973
Query: 329 NMYQE--QCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRL---QIMTKRYEALER 379
+ ++ Q + ++E++ +I E E ++++ + R+ Q+ K +E+LE
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 380 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGEL 439
RI+ E + +++ +++ LK +Q +A L E+ +R+ H+++ E
Sbjct: 2034 IRIVAKE--RDELRRIKESLK------------MERDQFIATLREMIARDRQNHQVKPEK 2079
Query: 440 KNLKSKVFGLENELR 454
+ L L LR
Sbjct: 2080 RLLSDGQQHLTESLR 2094
Score = 58.9 bits (141), Expect = 9e-09
Identities = 98/506 (19%), Positives = 205/506 (40%), Gaps = 80/506 (15%)
Query: 25 ELLEYYQKKMAECEAENE--DLLKKLELYKEACEGQHKLECDLQ-QREEEIAELQKALSD 81
E++E +K + + +NE +L+ + KE + K ++ + +EE+ L L
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
Query: 82 MQVCLFQEREHVLRLYSENDRL--RIRELEDKKK---------------IQNLLALVGTD 124
Q + QE+ H ++ E R R+ E+E+K K +Q ++ +
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156
Query: 125 AGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 184
E+ E +K L+ E Q + ++ I+K R + + S +R
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1216
Query: 185 D-IQTLILQVEALQAQLGEQTKLS----REQIEGLIEDRR---------IHLEEIQVQHQ 230
D ++ I ++EA Q E+ K++ +E E + E RR I+ ++++ H
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276
Query: 231 RNQNKIKEL---------TKNLHHTQELLYE--------STKDFLQLR------------ 261
+ Q +I L K + TQE + E +TKD L
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336
Query: 262 -SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK-- 318
E+Q + KS E+DNL + + V+ + ++ I + L + ES Q + + +
Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD 1396
Query: 319 ---DKLVQEKKLSNMYQEQCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRLQIMT 371
K+V E + + +E E+ R++E + + K++ + + + +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456
Query: 372 KRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 429
+ + E + + + +T ++KV LK+ E+ + + VN + E+
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE-----TEISTIQ 1511
Query: 430 RRAHKIQGELKNLKSKVFGLENELRL 455
++ I +L+N +++ E + +
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNI 1537
Score = 48.5 bits (114), Expect = 1e-05
Identities = 97/502 (19%), Positives = 199/502 (39%), Gaps = 101/502 (20%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI------------------ 72
++KM E + + ++LY+ E + K++ DL++ +
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 73 ----AELQKALSDMQVCLFQE-------REHVL------RLYSENDRLRIRELEDKKKIQ 115
EL+ ++D+Q L +E RE V+ L SE +RLR +E++DK +
Sbjct: 712 LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR-KEIQDKSEEL 770
Query: 116 NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ----SESSAFKADPKISKRRP 171
+++ E E HK + +Q ++ +G+ + ++S+ D + +
Sbjct: 771 HII------TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 172 SR---ERK-----ESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIE-----GLIED 217
E+K E +E ++I L + + + LG +T+LS + E +++
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 218 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL---YESTKDFLQLRSENQNKEKSWMLE 274
R +E+++ Q + + ++ + + E L E K Q + + + ++S +E
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 275 KDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQ 334
+D L S I ++++ L ES E I +LK K+ +E +
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNAL----ESLKQHQETINTLKSKISEEVSRN------ 994
Query: 335 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT---KRYEALERRR---------- 381
+ +EE ++E + + + K Q +T K E +E++R
Sbjct: 995 -LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 382 ---------ILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRA 432
I E E KTD+K + + ++ L + Q++ V A
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI-----VAQEKNHA 1108
Query: 433 HKIQGELKNLKSKVFGLENELR 454
K +GEL ++ +E +L+
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLK 1130
Score = 45.1 bits (105), Expect = 1e-04
Identities = 76/411 (18%), Positives = 180/411 (43%), Gaps = 36/411 (8%)
Query: 19 KLHPSKELLEYYQKKMAECEAEN----EDLLKKLELYKEACEGQHKLECDLQQREEEIAE 74
++ P K LL Q+ + E E ++LLK+ + E ++L DL++ E E
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133
Query: 75 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134
L + + + +H+ +L++ N R + KK++ +L+ V KE
Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK--------IKE 2185
Query: 135 PPHKVTILQKTIQAVGECEQSESSAFKADP-KISKRRPSRERKESSEHYQRDIQTLILQV 193
H+ +I + + + E E+ + K + PSRE ++ + D+ +
Sbjct: 2186 EQHE-SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 194 EALQAQLG------EQTKLSREQIEGLIED---RRIHLEEIQVQHQRNQNKIKELTKNLH 244
+ +++ +Q +R+++ +E+ R +E+++ Q+ ++I ++ +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304
Query: 245 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
+ + + +F + RS +KE W + +L K ++ + + + V
Sbjct: 2305 NRIIAIMNESTEF-EERSATISKE--WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP 2361
Query: 305 ESHHAQSEYIKSLKDKLVQEK--KLSNMY---QEQCISLEEELARIREEEGMRREI---F 356
+ ++ ++ S +L EK +L N +E + E ++ ++++E + +I
Sbjct: 2362 TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
Query: 357 KDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK--DLEQM 405
+ + ++ K L+ + + L+ + L + +K +I+ L+ KL DLE+M
Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472
Score = 44.7 bits (104), Expect = 2e-04
Identities = 69/386 (17%), Positives = 165/386 (42%), Gaps = 43/386 (11%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKALSDM 82
K L Y +++ E E ++ L ++E KE E + +++ + I E LQ+ L ++
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 83 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 142
+ L QE++ + +L + L+I + K I + + + +
Sbjct: 925 KT-LTQEKDDLKQL---QESLQIERDQLKSDIHDTVNM-----------------NIDTQ 963
Query: 143 QKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQAQLG 201
++ A+ +Q + + KIS+ + +E++ + + Q ++ ++ Q
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023
Query: 202 EQTKLSREQIEG--LIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259
+ T+ ++ +IE +R IQ +N+++++ +++ +E L K+ ++
Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQ-----EKNELQQMLESVIAEKEQLKTDLKENIE 1078
Query: 260 LRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKD 319
+ ENQ + + E + Q + KKE ++ + + E E + L++
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 320 KLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 379
K Q+Q ++++EE++ ++++ + + NK + T+R E ++
Sbjct: 1139 K-----------QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 380 --RRILEVEGFKTDIKVLRQKLKDLE 403
EV+ + KVL++ K E
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFE 1213
Score = 39.7 bits (91), Expect = 0.006
Identities = 84/439 (19%), Positives = 185/439 (42%), Gaps = 52/439 (11%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI- 72
++RL ++ KE LE + E E + +KL+ E + + + DL+Q +E +
Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 132
E + SD+ + + +L + + L+ + ++ I L + + + +
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLK----QHQETINTLKSKISEEVSRNLHME 998
Query: 133 KEPPHKVTILQKTIQAVG---ECEQSESSAFKADPK----ISKRRPSRERKESSEHYQRD 185
+ Q+ + + + E + AD K I ++R + Q+
Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058
Query: 186 IQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHH 245
++++I + E L+ L +E IE IE NQ +++ L L
Sbjct: 1059 LESVIAEKEQLKTDL-------KENIEMTIE---------------NQEELRLLGDELKK 1096
Query: 246 TQELLYESTKDFLQLRSE-NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 304
QE++ + ++ E ++ ++ +E+ K+K+ Q ++K+ ++ V M
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEE-----KLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 305 ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMG 364
E +E I++LK++L ++ + + + L ++L EE + I K+R K+
Sbjct: 1152 EMQKKINE-IENLKNELKNKELTLEHMETERLELAQKLNENYEEV---KSITKER--KVL 1205
Query: 365 KRLQ--IMTKRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLA 420
K LQ T+R R +E G +T ++K+ LK+ ++ + + + ++ A
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE--LRRSVSEKTA 1263
Query: 421 LLCEVRDSNRRAHKIQGEL 439
+ +D + K+Q E+
Sbjct: 1264 QIINTQDLEKSHTKLQEEI 1282
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 63.5 bits (153), Expect = 4e-10
Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 57/409 (13%)
Query: 35 AECEAENEDLLKKLELYKEACEGQHKLECDLQQRE---EEIAELQKALSDMQVCLFQERE 91
A C E+ + + E + +GQ EC+ + + +E+ L +AL+ + E
Sbjct: 99 AYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLST----PEE 154
Query: 92 HVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE 151
+ L + L LE+ + +Q + ++ ++ KE H + K I A +
Sbjct: 155 KLAALCKKYADL----LEESRSVQKQMKILQKKQAQIV---KEKVHLQSEHSKAILARSK 207
Query: 152 CE------QSESSAFKADPKISKRRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202
E Q + K + R RKE++ H+Q +IQ + Q + A+L +
Sbjct: 208 LESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQ 267
Query: 203 QTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRS 262
+ E+++ LIE + E I +R + + + + L T +L+ E+
Sbjct: 268 ENIELGEKLKKLIEQYALREEHIDKVFKRKELQQQLVDAKLQQTTQLIKEA--------D 319
Query: 263 ENQNKEKSWML----EKDNLMSKIKQYRVQCKKK----EDKIGKVLPVMHESHHAQSEYI 314
E +E+ ++L E + ++KQ VQ K++ DK + M +S+ + +
Sbjct: 320 EKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFR 379
Query: 315 KSLKDKLVQEKKLSN---MYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
+ ++ + KKL +++ + + + L ++ EE+ +R +K K LQI
Sbjct: 380 QEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVR--------DKEYKALQIKL 431
Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
+R E L R E ++VL+ EQ+ KA + A AN+DLA
Sbjct: 432 ERLEKLCRALQTERNELNEKVEVLK------EQVSIKAAIKA-ANRDLA 473
Score = 35.8 bits (81), Expect = 0.083
Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 29/240 (12%)
Query: 204 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 263
T+ SRE+I G + R + Q + N+NK K L K + + L +T + +
Sbjct: 102 TQESREEIPG--GEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQAL--NTLSTPEEKLA 157
Query: 264 NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ 323
K+ + +LE+ + K Q ++ KK+ ++ E H QSE+ K++ +
Sbjct: 158 ALCKKYADLLEESRSVQK--QMKILQKKQAQ-------IVKEKVHLQSEHSKAILARSKL 208
Query: 324 EKKLSNMYQEQCISLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERR 380
E + + EE + + REEE R+E F+ +++ +L+ L +
Sbjct: 209 ESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQE 268
Query: 381 RILEVEGFKTDIK--VLRQ-------KLKDLEQMLYKATVNARANQDLALLCEVRDSNRR 431
I E K I+ LR+ K K+L+Q L V+A+ Q L+ E + ++R
Sbjct: 269 NIELGEKLKKLIEQYALREEHIDKVFKRKELQQQL----VDAKLQQTTQLIKEADEKHQR 324
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 63.2 bits (152), Expect = 5e-10
Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83
++K E EA + K+ ++E + LE DL+++E EIA + KA+ +
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
Query: 84 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
+ L + + V L SE ++L + RE K + Q G++ E KE
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381
Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190
Q ++ E + S K ++S + RER E E R+ I+ L
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242
+VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293
L Q+ Y + L+LRSE EK + K+ S + +Q KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617
Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
E ++ D+T+ + LE +VE F + L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664
Score = 43.1 bits (100), Expect = 5e-04
Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)
Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224
+ R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++
Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144
Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271
++ ++ ++++L K++ Q L ++ T+ L+LR E++ E
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204
Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307
M E D M+ K K+ +QC KE+K P + S
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263
Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364
+ E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317
Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419
K +Q +T ++ E++ VE ++I+ L + L KA T + ++D
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373
Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452
AL +R N H+++ +K + ++ L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
Score = 34.3 bits (77), Expect = 0.24
Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)
Query: 310 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
K + RY++L V+ ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 63.2 bits (152), Expect = 5e-10
Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 83
++K E EA + K+ ++E + LE DL+++E EIA + KA+ +
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
Query: 84 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
+ L + + V L SE ++L + RE K + Q G++ E KE
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381
Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 190
Q ++ E + S K ++S + RER E E R+ I+ L
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 191 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 242
+VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 243 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 293
L Q+ Y + L+LRSE EK + K+ S + +Q KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
Query: 294 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 347
I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617
Query: 348 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
E ++ D+T+ + LE +VE F + L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664
Score = 43.1 bits (100), Expect = 5e-04
Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)
Query: 168 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 224
+ R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++
Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144
Query: 225 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 271
++ ++ ++++L K++ Q L ++ T+ L+LR E++ E
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204
Query: 272 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 307
M E D M+ K K+ +QC KE+K P + S
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263
Query: 308 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 364
+ E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317
Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 419
K +Q +T ++ E++ VE ++I+ L + L KA T + ++D
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373
Query: 420 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 452
AL +R N H+++ +K + ++ L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
Score = 37.7 bits (86), Expect = 0.022
Identities = 39/151 (25%), Positives = 75/151 (49%), Gaps = 18/151 (11%)
Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLALV 121
+ +++E +L+++LS V L EH+ R Y+ EN+RL+ E ++ Q L+ V
Sbjct: 1471 RDKQKENDKLRESLSRKTVSL----EHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526
Query: 122 GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEH 181
E++ +E V + Q+ + + QS KA K+ + R R+ S E
Sbjct: 1527 RCSGQELSRVQEE----VKLRQQLLSQNDKLLQSLRVELKAYEKLDEEH-RRLREASGEG 1581
Query: 182 YQ-----RDIQTLILQVEALQAQLGEQTKLS 207
++ RD+ +L+++++AL+ QL + S
Sbjct: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSIETS 1612
Score = 34.3 bits (77), Expect = 0.24
Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)
Query: 310 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
Query: 364 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
K + RY++L V+ ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 62.4 bits (150), Expect = 8e-10
Identities = 91/429 (21%), Positives = 183/429 (42%), Gaps = 70/429 (16%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE--LYKEACEGQH------KLECDL 65
EDR+A+ + E K +A+ + ++E ++ LE L +E + Q KLE D
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 66 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 125
++IAELQ ++++++ L ++ E ++Q LA V +A
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEE---------------------ELQAALARVEEEA 1096
Query: 126 GEVTYFCKEPPHKVTILQKTIQAVGECEQSE-SSAFKADPKISKRRPSRERKESSEHYQR 184
+ K K+ L+ I + E +SE +S KA+ ++R E E+ +
Sbjct: 1097 AQKNMALK----KIRELESQISELQEDLESERASRNKAE---KQKRDLGEELEALKTELE 1149
Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
D + L+++ ++ + ++ +E E+ + H +IQ Q++ ++EL + L
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLE---EEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 245 HTQEL-----------------LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 287
T+ + L K LQ + ++++K K + L K +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 288 QCKKKEDKIGK-------VLPVMHESHHAQSEYIK---SLKDKLVQEKKLSNMYQEQCIS 337
+ DK+ K V ++ +S S+ K +L+ +L ++L Q +S
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 338 LEEELARIREEE-GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE--VEGFKTDIKV 394
L +L ++ +E+ R ++ ++ K QI T + + ++ +E V +T +V
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 395 LRQKLKDLE 403
R+ KDLE
Sbjct: 1387 KRKLQKDLE 1395
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/292 (21%), Positives = 136/292 (46%), Gaps = 24/292 (8%)
Query: 173 RERKESSEHYQRDIQTLILQVEA----LQAQLGEQTKL--SREQIEGLIEDRRIHLEEIQ 226
RE++ ++E+ +++TL Q+ A LQ QL +T+L E++ + ++ LEEI
Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917
Query: 227 VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYR 286
+ + +E ++L ++ + ++ ++ + E ++ + LEK +K+K+
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 287 VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK---KLSNMYQEQCISLEEELA 343
+ ED+ K+ +E+ +L ++ + K KL N ++ LEE
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE--- 1034
Query: 344 RIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQKLKDL 402
R+R EE R+E+ K R G + +I E++ ++K+ L +K ++L
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSD---------QIAELQAQIAELKMQLAKKEEEL 1085
Query: 403 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
+ L A V A Q L ++R+ + ++Q +L++ ++ E + R
Sbjct: 1086 QAAL--ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Score = 53.5 bits (127), Expect = 4e-07
Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 71/473 (15%)
Query: 31 QKKMAECEAENEDL--LKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDM--QVCL 86
++ AE EA ++ L +EA E + +LE +Q E+ +L + D+ V
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 87 FQEREHVLRLYSENDRLRIRELEDKKK------------IQNLLALVGTDAGEVTYFCKE 134
++ + L E + ++ ELED+ + +Q + A D +E
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 135 PPHKVTILQKTIQAVGECEQSESS-AFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
++ + ++A E E+ + S A A K+ E S + RD I Q+
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQL 1640
Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
LQAQ+ + RE ++D R EEI Q + N+ K+K + + QE L +
Sbjct: 1641 RKLQAQMKD---CMRE-----LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 254 TKDFLQLRSE----------NQNKEKSWMLEKDNLMSKIKQYRVQCKKKE-------DKI 296
+ Q + E + K + EK L ++I Q + ++++ D++
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 297 GKV--------LPVMHESHHAQ---------SEYIKSLKDKLVQ-EKKLSNMYQEQCISL 338
K + E HAQ K LK KL + E + + Y+ +L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 339 EEELARIREE---EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVL 395
E ++A++ E+ E R+ + + K+L+ + + + ERR E +K
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-ERR---NAEQYKDQADKA 1868
Query: 396 RQKLKDLEQMLYKATVNA-RANQD-LALLCEVRDSNRRAHKIQGELKNLKSKV 446
+LK L++ L +A A RAN L E+ D+ A + E+ +LK+K+
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 50.4 bits (119), Expect = 3e-06
Identities = 99/467 (21%), Positives = 203/467 (43%), Gaps = 65/467 (13%)
Query: 23 SKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-------- 74
++EL K E E DL ++E +E C+ + +QQ +E+ E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 75 -----LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
L+K ++ ++ +E + +L +N +L ++KK +++ +A E T
Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILE--DQNCKL----AKEKKLLEDRIA-------EFT 1005
Query: 130 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKE---SSEHYQRDI 186
E K L K +++ A D + RR ++R+E + + D
Sbjct: 1006 TNLTEEEEKSKSLAKL--------KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 187 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 246
L Q+ LQAQ+ E K+ + E ++ +EE Q KI+EL +
Sbjct: 1058 TDLSDQIAELQAQIAE-LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 247 QELLYESTKDFLQLRSENQNKEKSWMLE------KDNLMSKIKQYRVQCKKKEDK--IGK 298
QE L ++ + ++E Q ++ LE +D L S Q ++ K++++ + K
Sbjct: 1117 QEDL--ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 299 VLPVMHESHHAQ--------SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 350
L ++H AQ S+ ++ L ++L Q K++ ++ +LE E + E
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 351 MRREIFKDRTNKMGK---RLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 407
+ + D +K K +LQ + ++ ER R E+ T ++V +L ++ +L
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVTKLQV---ELDNVTGLLS 1290
Query: 408 KA-TVNARANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
++ + +++ +D AL +++D+ + + +L +K+ +E+E
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 29.3 bits (64), Expect = 7.7
Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 21/126 (16%)
Query: 332 QEQCISLEEELARIREE----EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387
+E+ ++ EEEL ++RE+ E E+ ++ M ++LQ+ E L+ L E
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAEA 899
Query: 388 FKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVF 447
+ + L K ++LE++ + L V + R +Q E K ++ +
Sbjct: 900 EELRAR-LTAKKQELEEICHD------------LEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 448 GLENEL 453
LE +L
Sbjct: 947 ELEEQL 952
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 62.4 bits (150), Expect = 8e-10
Identities = 90/440 (20%), Positives = 181/440 (41%), Gaps = 54/440 (12%)
Query: 14 EDRLAKLHPSKELL-EYYQKKMAECEAENEDL------LKKLELYKEACEG--------- 57
++ +AKL K+ L E +Q+ + + +AE + + KLE + EG
Sbjct: 989 DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR 1048
Query: 58 ------QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK 111
+ KLE DL+ +E +++ + L ++ + L S+ + + E++ +
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108
Query: 112 KKIQNLLALV---GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK 168
KKI+ L A + G + + + + L + ++ + E + A A +++K
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168
Query: 169 RRPSRERKESSEHYQRDIQTLILQVEAL-----------QAQLGEQTKLSREQIEGLIED 217
+R + +K +RD++ LQ EA+ A+LGEQ + ++++ +E
Sbjct: 1169 KREAEFQK-----LRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-NLQRVKQKLEK 1222
Query: 218 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDN 277
+ L+ N I + NL L + + E Q ++
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282
Query: 278 LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCIS 337
L ++ +Y Q +K+ + + + S A ++ I+ LK +L +E K N S
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338
Query: 338 LEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 394
+ +R EEE + + +K + +YE +R E+E K K
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK---KK 1395
Query: 395 LRQKLKDLEQMLYKATVNAR 414
L Q+L++ E+ + VNA+
Sbjct: 1396 LAQRLQEAEE--HVEAVNAK 1413
Score = 53.5 bits (127), Expect = 4e-07
Identities = 92/462 (19%), Positives = 191/462 (41%), Gaps = 65/462 (14%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQ---HKLECDLQQREEEIAE 74
+L K + E ++ EN++L +++ +L ++ EG H+LE +Q E+E E
Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542
Query: 75 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 134
+Q AL + + L E +LR+ E ++++ EV E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVK---------------------SEVDRKIAE 1581
Query: 135 PPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 194
++ L++ V E QS D +I R + K+ E D+ + +Q+
Sbjct: 1582 KDEEIDQLKRNHTRVVETMQS-----TLDAEIRSRNDALRVKKKME---GDLNEMEIQLN 1633
Query: 195 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
+L ++ + +G++++ ++HL++ R Q +KE + LL
Sbjct: 1634 HAN-RLAAESLRNYRNTQGILKETQLHLDDA----LRGQEDLKEQLAIVERRANLLQAEI 1688
Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ-------CKKKEDKI----GKVLPVM 303
++ + + K E + +++ Q KK E+ + +V V+
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Query: 304 HESHHAQSEYIKSLKD------KLVQEKKLSNMYQEQCISLEEELA----RIREEEGMRR 353
ES +A+ + K++ D +L +E+ S + +LE+ + R+ E E +
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808
Query: 354 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413
+ K + K+ R++ + E ++R V+G + +++K+L + N
Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH----ERRVKELTYQTEEDRKNV 1864
Query: 414 RANQDLA--LLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 453
QDL L +V+ R+A + + + SK L++EL
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906
Score = 52.0 bits (123), Expect = 1e-06
Identities = 98/453 (21%), Positives = 190/453 (41%), Gaps = 50/453 (11%)
Query: 17 LAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-L 75
++K+ + + QKK+ E +A E+L +++E + + K DL + EEI+E L
Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153
Query: 76 QKA--LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLL--ALVGTDAGEVTYF 131
++A + QV L ++RE +E +LR R+LE+ + AL A +
Sbjct: 1154 EEAGGATSAQVELNKKRE------AEFQKLR-RDLEEATLQHEAMVAALRKKHADSMAEL 1206
Query: 132 CKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER------------KESS 179
++ + + QK + E + ISK + + E+ K
Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266
Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 239
E QR I L Q LQ + GE ++ E+ + L+ + Q + +++++E
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEK-DALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 240 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 299
TK + L S D LR E +E+ E +SK Q + K
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLR-EQYEEEQEGKAELQRALSKANSEVAQWRTK------- 1377
Query: 300 LPVMHESHHAQ-SEYIKSLKDKLVQEKKLSNMYQE----QCISLEEELARIREE-EGMRR 353
+E+ Q +E ++ K KL Q + + + E +C SLE+ R++ E E +
Sbjct: 1378 ----YETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 354 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 413
++ +R+N L + ++ + + E + +++ +++ + L L+K V
Sbjct: 1434 DV--ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK--VKN 1489
Query: 414 RANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 446
+ L L +R N+ +Q E+ +L ++
Sbjct: 1490 VYEESLDQLETLRRENK---NLQQEISDLTEQI 1519
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/421 (19%), Positives = 181/421 (42%), Gaps = 44/421 (10%)
Query: 33 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREH 92
K AE E E + ++ + K+ K E ++ EE++ L K +D+Q
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELA---KSEAKRKELEEKMVTLLKEKNDLQ--------- 891
Query: 93 VLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH-KVTILQKTIQAVGE 151
L++ SE D L E ++ I+N + L EVT +E + K + E
Sbjct: 892 -LQVQSEADSLADAEERCEQLIKNKIQL-EAKIKEVTERAEEEEEINAELTAKKRKLEDE 949
Query: 152 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211
C + + + ++K + K ++E+ +++ + ++ A+L ++ K +E
Sbjct: 950 CSELKKDIDDLELTLAK---VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006
Query: 212 EGLIEDRRIHLEEIQV---QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 268
+ ++D + +++ + + + ++ +L +L ++L + + +L + + +
Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066
Query: 269 KSWM-LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 327
+S M +E D +Q + +KKE +I S I ++D+ E +L
Sbjct: 1067 ESTMDMENDK-----QQLDEKLEKKEFEI--------------SNLISKIEDEQAVEIQL 1107
Query: 328 SNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 387
+E +EE I E R + K R++ + + L+ +++R E +VE
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVEL 1166
Query: 388 FKTDIKVLRQKLKDLEQ--MLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSK 445
K ++ +DLE+ + ++A V A + + E+ + +++ +L+ KS+
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 446 V 446
+
Sbjct: 1227 L 1227
Score = 45.8 bits (107), Expect = 8e-05
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 54/340 (15%)
Query: 152 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 211
CEQ + + + KI + ER E E ++ ++E E ++L ++
Sbjct: 908 CEQLIKNKIQLEAKIKE---VTERAEEEEEINAELTAKKRKLE------DECSELKKD-- 956
Query: 212 EGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW 271
I+D + L +++ + +NK+K LT+ + E + + +K+ L+ +Q
Sbjct: 957 ---IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 272 MLEKD--NLMSKI------------------KQYRVQCKKKEDKIGKVLPVMHESHHAQS 311
E+D N+++K K+ R+ ++ + K+ L + ES
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073
Query: 312 EYIKSLKDKLVQEKK-------LSNMYQEQCISLE-----EELARIREEEGMRREIFKDR 359
+ L +KL EKK +S + EQ + ++ +EL EE G E +
Sbjct: 1074 NDKQQLDEKL--EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131
Query: 360 TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
K K+ +++ E + R LE G T +V K ++ E + + Q
Sbjct: 1132 RAKAEKQRSDLSRELEEISER--LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 420 ALLCEVRDSNRRAHKIQGE----LKNLKSKVFGLENELRL 455
A++ +R + + GE L+ +K K+ ++EL++
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/429 (21%), Positives = 193/429 (44%), Gaps = 46/429 (10%)
Query: 35 AECEAENEDLLKKLELYKEAC----EGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
A+ E + +DL LE K+ + KLE DL+ +E I +L+ ++ L ++
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE 1088
Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV----TYFCKEPPHKVTILQKTI 146
+ +L ++ D ++ L+ +KKI+ L A + E+ T K + + L + +
Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR-SDLAREL 1147
Query: 147 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 206
+ + E + S A A +++K+R + +K +RD++ LQ EA A L ++
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQK-----MRRDLEEATLQHEATAATLRKKQAD 1202
Query: 207 S----REQIEGLIE-DRRIHLE--EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 259
S EQI+ L +++ E E++++ + I+ L+K+ + + F +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262
Query: 260 LRSENQNKEK---SWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS 316
++++++ + + ++K L ++ + + ++KE I + + +S A ++ ++
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ----LTKSKQALTQQLEE 1318
Query: 317 LKDKLVQEKKLSNMYQEQCISLEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKR 373
LK ++ +E K N S + +R EEE + + +K + +
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Query: 374 YEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAH 433
YE +R E+E K K L Q+L++ E+ AN A L +
Sbjct: 1379 YETDAIQRTEELEEAK---KKLAQRLQEAEEN------TETANSKCASL------EKTKQ 1423
Query: 434 KIQGELKNL 442
++QGE+++L
Sbjct: 1424 RLQGEVEDL 1432
Score = 53.1 bits (126), Expect = 5e-07
Identities = 82/446 (18%), Positives = 187/446 (41%), Gaps = 60/446 (13%)
Query: 6 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 65
E+ L E+R L SK LLE K++ E E E++ +L K
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK------------- 944
Query: 66 QQREEEIAELQKALSDMQVCL--FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGT 123
+ E++ + L++ + D+++ L ++ +H +EN K++NL +
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHA----TEN------------KVKNLSEEMTA 988
Query: 124 DAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183
++ KE Q+T+ + E + K + K+ ++ E E
Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE--- 1045
Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243
+ L +E + +L K+S+E I L D+ ++I+ + ++ + ++ +L +
Sbjct: 1046 ---KKLRADLERAKRKLEGDLKMSQESIMDLENDK----QQIEEKLKKKEFELSQLQAKI 1098
Query: 244 HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
Q + K +L++ + E+ E L +KI++ R ++ ++I + L
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERL--- 1154
Query: 304 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
E+ A S I+ K + + +K+ +E + E A +R+++ D ++
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA-------DSVAEL 1207
Query: 364 GKRLQIMTKRYEALERRRI---LEVEGFKTDIKVLRQKLKDLEQMLYK-----ATVNARA 415
G+++ + + + LE+ + +E++ ++I+ L + ++E+ + + A+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 416 NQDLALLCEVRDSNRRAHKIQGELKN 441
Q L+ ++ R GEL +
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSH 1293
Score = 52.4 bits (124), Expect = 9e-07
Identities = 79/397 (19%), Positives = 166/397 (41%), Gaps = 38/397 (9%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78
KL S+ LE QK E + + +L K Y+E + L + + +EEI++L +
Sbjct: 1463 KLDESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 79 LSDMQVCLFQEREHVLRLYSEND---RLRIRELE-----DKKKIQNLLALVGTDAGEVTY 130
+++ L QE E +L + ++ + E+E ++ KI + + E+
Sbjct: 1520 IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578
Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 190
E ++ L++ Q E QS D +I R + K+ E D+ +
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQS-----VLDAEIRSRNDALRLKKKME---GDLNEME 1630
Query: 191 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 250
+Q+ Q+ E K R ++G ++D ++HL++ R+ +KE + LL
Sbjct: 1631 IQLGHSNRQMAETQKHLR-TVQGQLKDSQLHLDDA----LRSNEDLKEQLAIVERRNGLL 1685
Query: 251 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310
E + +++ + E++ L + L+ + ++ + I + + Q
Sbjct: 1686 LEELE---EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742
Query: 311 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370
+E S+++ E+K + + EE +++E+ + +M K L+
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHL-----ERMKKNLEQT 1793
Query: 371 TKRYE-ALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
K + L+ L ++G K I+ L ++++LE L
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Score = 48.5 bits (114), Expect = 1e-05
Identities = 98/477 (20%), Positives = 190/477 (39%), Gaps = 68/477 (14%)
Query: 30 YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKA--LSDMQVCL 86
+QKK+ E +A E+L +++E K DL + EEI+E L++A + Q+ +
Sbjct: 1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167
Query: 87 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLA--LVGTDAGEVTYFCKEPPHKVTILQK 144
++RE +E ++R R+LE+ A L A V ++ + + QK
Sbjct: 1168 NKKRE------AEFQKMR-RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 145 TIQAVGECEQSESSAFKADPKISKRRPSRER------------KESSEHYQRDIQTLILQ 192
+ E + +SK + + ER K E + I L +Q
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 193 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE 252
LQ Q GE + E+ E LI + + Q + + +++E TK + L
Sbjct: 1281 KARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 253 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 312
S D LR E +E+ E +SK Q + K + + E A+
Sbjct: 1340 SRHDCDLLR-EQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK-- 1394
Query: 313 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR-EEEGMRREI---------------- 355
K L +L + ++ + +C SLE+ R++ E E + R++
Sbjct: 1395 --KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452
Query: 356 -------FKDRTNKMGKRLQIMTKRYEALE----------RRRILEVEGFKTDIKVLRQK 398
+K + ++ L+ K +L + ++E + + K L+++
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512
Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRA--HKIQGELKNLKSKVFGLENEL 453
+ DL + + + N + + L E S+ + +++G L++ +SK+ ++ EL
Sbjct: 1513 ISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Score = 41.2 bits (95), Expect = 0.002
Identities = 68/346 (19%), Positives = 149/346 (43%), Gaps = 61/346 (17%)
Query: 161 KADPKISKRRPSRERKESSEHYQRDIQTLIL---QVEALQAQLGEQTKLSRE-------- 209
K D ++ + + ++ E + I++ IL +V+ L +L E+ +++ E
Sbjct: 888 KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
Query: 210 -----QIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 264
++ I+D + L +++ + +NK+K L++ + +E + + TK+ L+ +
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH 1007
Query: 265 QNKEKSWMLEKDNL--------------------MSKIKQYRVQCKKKEDKIGKVLPVMH 304
Q +E+D + + + K+ R ++ + K+ L +
Sbjct: 1008 QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067
Query: 305 ES----HHAQSEYIKSLKDKLVQEKKL-SNMYQEQCISLE------EELARIRE------ 347
ES + + + + LK K + +L + + EQ SL+ E ARI E
Sbjct: 1068 ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127
Query: 348 -EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 406
E +R +I K R++ + + L+ +++R E ++E K ++ +DLE+
Sbjct: 1128 AEHTLRAKIEKQRSD-LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 407 YK-----ATVNARANQDLALLCEVRDSNRRA-HKIQGELKNLKSKV 446
+ AT+ + +A L E D+ +R K++ E LK ++
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Score = 38.9 bits (89), Expect = 0.010
Identities = 59/294 (20%), Positives = 118/294 (40%), Gaps = 56/294 (19%)
Query: 160 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219
FK P + +E E ++R + L + EA + +L E++ L++++
Sbjct: 838 FKIKPLLKSAEAEKEMATMKEDFERTKEELA-RSEARRKEL-------EEKMVSLLQEKN 889
Query: 220 IHLEEIQVQHQ-RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL 278
++QVQ + N +E + L ++ LL K+ + E + + +K NL
Sbjct: 890 DL--QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
Query: 279 MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 338
K K+ D + L + + HA +K+L +++ +L
Sbjct: 948 EDKCSSL----KRDIDDLELTLTKVEKEKHATENKVKNLSEEMT--------------AL 989
Query: 339 EEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQK 398
EE ++++ +E+ +E + + LQ+ + L K + K L Q+
Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDD----LQVEEDKVNGL----------IKINAK-LEQQ 1034
Query: 399 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 452
DLE L Q+ L ++ + R K++G+LK + + LEN+
Sbjct: 1035 TDDLEGSL---------EQEKKLRADLERAKR---KLEGDLKMSQESIMDLEND 1076
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/504 (18%), Positives = 208/504 (41%), Gaps = 68/504 (13%)
Query: 14 EDRLAKLHPSKELLEY----YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
E ++++ K LL++ YQ+K + + ++ ++ K+ E K+ + Q
Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRI---------RELEDKKKI------ 114
E++++LQK L + L E + +RL + + REL+++ +I
Sbjct: 538 EKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKS 597
Query: 115 ---------QNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE-CEQSESSAFKADP 164
Q +L D G + + ++T LQ+ ++ + E+ E +A
Sbjct: 598 QTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQD 657
Query: 165 KISKRRPSRERKESSEHYQ-RDIQTLILQV-------------------EALQAQLGEQT 204
++ + E +Y+ + +Q + Q EA + E
Sbjct: 658 MLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEME 717
Query: 205 KLSREQIEGL--IEDRRIHLEE----IQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258
K +E+ E E+R + +E+ + V +++Q K++ LT N ++ + T L
Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT---L 774
Query: 259 QLRSEN------QNKEKSWMLEKDNLMSKIKQYRVQCK---KKEDKIGKVLPVMHESHHA 309
QL E+ QN+ K+ E DNL KQ + + + + + L + + +
Sbjct: 775 QLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRG 834
Query: 310 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 369
++ L+D+L E+ S +Y+ Q L+EE+ E + + ++ + +L +
Sbjct: 835 NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDL 894
Query: 370 MTKRYEALE-RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDS 428
+ E+ + R +LE + F+ + + ++ +++ K +R + ++L + +
Sbjct: 895 AETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEI 954
Query: 429 NRRAHKIQGELKNLKSKVFGLENE 452
RR ++ E + + LE E
Sbjct: 955 LRRENEELTEKMKKAEEEYKLEKE 978
Score = 45.4 bits (106), Expect = 1e-04
Identities = 57/248 (22%), Positives = 101/248 (40%), Gaps = 34/248 (13%)
Query: 229 HQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ 288
++ + N K L ++L T L E + +QL+ E + K ++ ++ D +M ++ + Q
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473
Query: 289 CKKKEDKIGKVLPVMHESHHAQSEY-----------------IKSLKDKLVQEKKLSNMY 331
+ E + ++ H +EY + +LKD+L KK+S
Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533
Query: 332 Q---EQCISLEEELAR----IREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE 384
Q E+ L+++L +R E + K T Q+ + E ER RILE
Sbjct: 534 QLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILE 593
Query: 385 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 444
+TD KD Q+ +A + A + D R +Q E+K+LK
Sbjct: 594 NSKSQTD--------KDYYQL--QAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKH 643
Query: 445 KVFGLENE 452
+ +E E
Sbjct: 644 NLEKVEGE 651
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 61.6 bits (148), Expect = 1e-09
Identities = 104/477 (21%), Positives = 199/477 (41%), Gaps = 68/477 (14%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
E+R +L S+E E Q+++ + E + K E +E E + K E + ++RE+E+A
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 74 ELQKALSDMQVCLFQEREHV--------LRLYSENDR------LRIRELEDKKKIQNLLA 119
E ++ Q RE + +L SE D R R+ E +++ Q
Sbjct: 687 EEEQE---------QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 120 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS 179
E+ + +E H+ ++ + Q+E + + ++S R P RE++E
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER- 796
Query: 180 EHYQRDIQTLILQVEALQAQLGEQTKL-SREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE 238
Q+ A + Q EQ L E+ E RR +E+Q + Q + +E
Sbjct: 797 ------------QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 239 LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK 298
+ L ++ L E D + RS+ Q +++ W + + + + ++++ K
Sbjct: 845 RAQQLQEEEDGLQE---DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901
Query: 299 VLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD 358
++ E + + + QE++ Y+E+ +EE +REE RR ++
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQ----YREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 359 RTNKMGKRLQIMTKRY--EALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR-- 414
R + K+LQ ++ E E+RR E E + + L+Q + EQ+L + R
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ---EEEQLLREEREKRRRQ 1014
Query: 415 ------------ANQDLALLCEVRDSNR-----RAHKIQGELKNLKSKVFGLENELR 454
++ LL E R+ R R ++ + EL+ + ++ G E E R
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Score = 59.7 bits (143), Expect = 5e-09
Identities = 104/476 (21%), Positives = 199/476 (41%), Gaps = 88/476 (18%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 69
L E++L P K + +KK E E E ++ +L +E E + + E + Q R+
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 70 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALVGTDAG 126
++ ELQ QE E +LR E RL+ RE E+++ Q L+G +
Sbjct: 1023 KD--ELQ-----------QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE-- 1067
Query: 127 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER--KESSEHYQR 184
+ L++ + E +Q E + +P+ +RR RER +E E Q
Sbjct: 1068 -------RETRRRQELERQYRKEEELQQEEEQLLREEPE-KRRRQERERQCREEEELQQE 1119
Query: 185 DIQTLILQVE-----ALQAQLGEQTKLSREQIEGL----------------IEDRRIHLE 223
+ Q L + E L+ Q E+ ++ +E+ + L E+ + E
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 224 EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIK 283
E Q+ + + + +E + +EL + K + R E+Q + W E + + ++
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQ--RYRDEDQRSDLKWQWEPEK-ENAVR 1236
Query: 284 QYRVQCKKKEDKIGKVLPVM----HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 339
+V CK +E++ + L +S + +++ ++++ +++ E
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 340 EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL 399
E+L R ++E RR DR ++ K+L R E E+RR E + +K
Sbjct: 1297 EQLEREEQKEAKRR----DRKSQEEKQL----LREEREEKRRRQETD----------RKF 1338
Query: 400 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 455
++ EQ+L + ++ L + RD R +++ + + K LE E RL
Sbjct: 1339 REEEQLL-------QEREEQPLRRQERDRKFREEELRHQEQGRKF----LEEEQRL 1383
Score = 53.1 bits (126), Expect = 5e-07
Identities = 81/379 (21%), Positives = 160/379 (42%), Gaps = 38/379 (10%)
Query: 105 IRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ-SESSAFKAD 163
+R D K + +L L+ D+ F + + Q A+G+ E + D
Sbjct: 45 LRRPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCD 104
Query: 164 PKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE------- 216
K S + R+ ++ RD Q L+ E Q + ++ + RE EG +
Sbjct: 105 GKESLLQDRRQEEDQRRFEPRDRQ---LEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161
Query: 217 ---DRRIHLEEIQVQHQRNQNKIKELTKNL-------HHTQELLYEST---KDFLQLRSE 263
DR+ EE+ Q Q Q + + + H T+E E ++ L+LR +
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221
Query: 264 NQNKEKSWMLEKDNLM---SKIKQYRVQ---CKKKEDKIGKVLPVMHESHHAQSEYIKSL 317
+ +++ E+ + + + K++R + +K+E+K+ + P + E ++ L
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 318 KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEAL 377
+ + ++ ++ Q+Q + E++L R +EEE RRE ++R + +R Q +R + L
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEE--RREQQEERREQQERREQQEERREQQL 339
Query: 378 ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN--RRAHKI 435
R E E + Q+ + EQ L + R Q L ++R RR ++
Sbjct: 340 RR----EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 436 QGELKNLKSKVFGLENELR 454
+ E + + + E +LR
Sbjct: 396 RREQQLRREQQLRREQQLR 414
Score = 53.1 bits (126), Expect = 5e-07
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 53/440 (12%)
Query: 10 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL------ELYKEACEGQHKLEC 63
L E++L KL + E +++ + E L++ E +E E Q + E
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 64 DLQQREEEIAELQKALSDMQVCLFQE---REHVLRLYSENDRL--RIRELEDKKKIQNL- 117
++RE+++ Q+ + Q+ QE RE LR E +R ++R + ++ Q L
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 118 ----LALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR 173
L E ++ + L++ Q E E+ E K + + ++R R
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE-ERHEQKHEQERREQRLKR 449
Query: 174 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ--IEGLIEDRRIHLEEIQVQHQR 231
E++E + +R+ +T + E + QL + R + ++ E+RR E + Q +R
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 232 NQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------EKSWMLEKDNLMSKIK- 283
Q + +E +E L + + QLR E + + E+ LE++ ++K
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 284 ---QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEE 340
+ R Q K+E++ + E + L+ +L +E ++ + QE+ E+
Sbjct: 570 EQEERRDQLLKREEE--------RRQQRLKREQEERLEQRLKRE-EVERLEQEE--RREQ 618
Query: 341 ELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK 400
L R EE R+++ K + ++ Q+ ++ E E+R E E +
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE------------E 666
Query: 401 DLEQMLYKATVNARANQDLA 420
LEQ L + R Q+LA
Sbjct: 667 RLEQRLKREHEEERREQELA 686
Score = 52.8 bits (125), Expect = 7e-07
Identities = 87/440 (19%), Positives = 187/440 (42%), Gaps = 60/440 (13%)
Query: 40 ENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 99
E E +++ E ++ E + +L Q+R + E ++ L + + +E + E
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLR---QERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 100 NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA 159
+LR +E + K + Q L + +EP K ++ + +Q +
Sbjct: 1491 EQQLRRQERDRKFREQELRS-------------QEPERKFLEEEQQLHR----QQRQRKF 1533
Query: 160 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 219
+ + ++ ++ ++R++ + R+ + L Q E+ +LSR++ DR+
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQL--------RQEREEQQLSRQE-----RDRK 1580
Query: 220 IHLEEIQVQHQRNQNKIKELTKNLHHT---QELLYESTKDF------LQLRSENQ----N 266
LEE +V+ Q + K E + L Q+L E + F LQ R E Q
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 267 KEKSWMLEKDNL--MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ- 323
+++ ++ E+ L + +Q R +K + ++L E + E + +++ Q
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 324 ---EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER- 379
E++ + +EQ + +E + REEE +R+E +++ + + +I+ + ER
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 380 ----RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKI 435
RR F+ + + LRQ+ + EQ L + + ++ L E + R +
Sbjct: 1761 EQQLRRQERDRKFREE-EQLRQERE--EQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 436 QGELKNLKSKVFGLENELRL 455
G+ + + ++ E E RL
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRL 1837
Score = 51.6 bits (122), Expect = 1e-06
Identities = 101/446 (22%), Positives = 187/446 (41%), Gaps = 52/446 (11%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
+ R + P +E E +++ E E E + L ++ +L + Q LQ+ E+ +
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ------LQEEEDGLQ 857
Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE-LEDKKKIQNLLA----LVGTDAGEV 128
E Q+ + Q R+ R E +R R R L K +Q L L+ + E+
Sbjct: 858 EDQERRRSQE----QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 129 TYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQT 188
+E + Q+ E Q E + + +RR RER+ Y++D +
Sbjct: 914 QREEREKRRRQE--QERQYREEEQLQQEEEQLLREEREKRRRQERERQ-----YRKD-KK 965
Query: 189 LILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQE 248
L + E L LGE+ + R Q E + + EE ++Q + Q +E K E
Sbjct: 966 LQQKEEQL---LGEEPEKRRRQ-----EREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 249 LLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ---CKKKEDKIGKVLPVMH- 304
Y KD LQ E +E+ EK L + +QYR + +++E +G+
Sbjct: 1018 RQYRK-KDELQQEEEQLLREER---EKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 305 ---ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN 361
E + + E ++ +++L++E+ QE+ EE +EEE + RE +R
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE---EREK 1130
Query: 362 KMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
+ + L+ + E + E ++L E K + L ++ ++ E++ + R Q+
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE- 1189
Query: 420 ALLCEVRDSNRRAHKIQGELKNLKSK 445
+ R R ++ + EL+ K K
Sbjct: 1190 ----KRRQERERQYREEEELQRQKRK 1211
Score = 48.9 bits (115), Expect = 9e-06
Identities = 70/341 (20%), Positives = 141/341 (41%), Gaps = 63/341 (18%)
Query: 14 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 73
E L P ++ LE Q+ + + + + L ++ +L ++ Q + + D + REEE
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQ-QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-- 1561
Query: 74 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 133
+L++ + Q+ QER+ RL + ++R E ++K + G+ +
Sbjct: 1562 QLRQEREEQQLSR-QERDRKFRLEEQ----KVRRQEQERKFMEDEQQLRRQEGQ-QQLRQ 1615
Query: 134 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 193
E K ++ Q + E E+ + + D K + P R+E + + D +
Sbjct: 1616 ERDRK---FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 194 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 253
E L Q GE+ +L R++ DR+ EE Q++ Q + K + + L + L
Sbjct: 1673 EQL-LQEGEEQQLRRQE-----RDRKFREEEQQLRRQERERKFLQEEQQLRRQE--LERK 1724
Query: 254 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 313
++ QLR E + ++ + + ++YR
Sbjct: 1725 FREEEQLRQETEQEQ----------LRRQERYR--------------------------- 1747
Query: 314 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 354
K+++E++L +EQ + +E + REEE +R+E
Sbjct: 1748 ------KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Score = 47.8 bits (112), Expect = 2e-05
Identities = 86/434 (19%), Positives = 182/434 (41%), Gaps = 49/434 (11%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
+E E ++ E E + L ++ +L +E Q + E L+ RE+++ Q+ + Q
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQ---QLRREQQLR-REQQLRREQQLRREQQ 412
Query: 84 VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 143
+ Q+ +L E + R + ++++ + L + + + +E + +
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD--WLKREEETERHEQE 470
Query: 144 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESS---EHYQRDIQTLILQVEA--LQA 198
+ Q + ++ E + +RR +ER+E E +R Q L Q E LQ
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 199 QLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQNKIKELTKNLHHTQELLYEST 254
+L + +L REQ E+RR L EE +++ +R + ++K E
Sbjct: 531 RLRSEQQLRREQ-----EERREQLLKREEEKRLEQERREQRLKREQ-----------EER 574
Query: 255 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYI 314
+D L R E + +++ +++ L ++K+ V+ ++E++ + L + + +
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 315 KSLKDKLVQEKKLSNMYQEQCIS----------LEEELARIREEEGMRREIFKDRTNKMG 364
KS + + ++++L QE+ LE+ L R EEE +E+ ++ +
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 365 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCE 424
+R++ +++ LE E KV + K Q + R ++ L +
Sbjct: 695 ERIKSRIPKWQWQ-----LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 425 VRDSNRRAHKIQGE 438
RAH+ Q E
Sbjct: 750 ---EEERAHRQQQE 760
Score = 46.2 bits (108), Expect = 6e-05
Identities = 100/460 (21%), Positives = 193/460 (41%), Gaps = 63/460 (13%)
Query: 22 PSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD---------LQQREEEI 72
P +E LE ++K A+ K+L L +E E + + E D LQ+REE+
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQL-LREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 73 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK--KKIQNLLALVGTDAGEVTY 130
Q+ + + +E + E RLR +E E K K+ Q L
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR------------ 1400
Query: 131 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ-R 184
C+E + L++ E+ + S + D K + RR RERK E Q R
Sbjct: 1401 -CQEREQQ---LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456
Query: 185 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 244
+ + E Q E+ +L R++ DR+ EE Q++ Q K +E
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQE-----RDRKFLEEEQQLRRQERDRKFRE------ 1505
Query: 245 HTQEL-LYESTKDFLQLRSE--NQNKEKSWMLEKDNLMSKIKQYRVQCKK--KEDKIGKV 299
QEL E + FL+ + Q +++ ++ E+ L +Q R Q ++ ++ K +
Sbjct: 1506 --QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR---RQERGQQRRQDRDRKFREE 1560
Query: 300 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDR 359
+ E Q + + ++E+K+ QE+ +E+ ++R +EG ++++ ++R
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ--QLRRQEG-QQQLRQER 1617
Query: 360 TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK-----DLEQMLYKATVNAR 414
K + Q++ +R E R+ + + + + ++ RQ+ + D ++ + +
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677
Query: 415 ANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
++ L + RD R + Q + + K E +LR
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Score = 44.7 bits (104), Expect = 2e-04
Identities = 84/422 (19%), Positives = 185/422 (43%), Gaps = 43/422 (10%)
Query: 38 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 97
E +E+ L++ EL + +G+ + + ++R++ + + ++ +++RE VLR
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE------WRKRETVLR-- 254
Query: 98 SENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE 156
E ++L+ E + ++++Q L + E+ +E + L++ Q + E+
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 157 SSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 216
+ + +RR +E + + + + Q+ Q + + +L REQ E
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ----EE 370
Query: 217 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD 276
+RR + Q +R Q +E + L Q+L E QLR E Q + + + +
Sbjct: 371 ERREQQLRREQQLRREQQLRRE--QQLRREQQLRREQ-----QLRREQQLRREQQLRREQ 423
Query: 277 NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCI 336
L + ++ R + K ++++ + L E +D L +E++ QE+
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEER----------RDWLKREEETERHEQER-- 471
Query: 337 SLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIK 393
+++L R +EEE R + ++R + +R Q + + E +R+ E + +
Sbjct: 472 -RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE----EEE 526
Query: 394 VLRQKLKDLEQMLYKATVNARANQDLALLCEVR-DSNRRAHKIQGELKNLKSKVFGLENE 452
L+Q+L+ +Q+ + R Q L E R + RR +++ E + + ++ E E
Sbjct: 527 RLQQRLRSEQQL--RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 453 LR 454
R
Sbjct: 585 RR 586
Score = 42.4 bits (98), Expect = 9e-04
Identities = 61/341 (17%), Positives = 144/341 (42%), Gaps = 43/341 (12%)
Query: 31 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 90
++K+ E E + + + +L ++ EGQ +L Q+R+ + E ++ L + + +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQ--EGQQQLR---QERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 91 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 150
E + E +LR +E E + + + ++ Q +
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHD----------------------RDRKFREEEQLLQ 1677
Query: 151 ECEQSESSAFKADPKISK-----RRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 202
E E+ + + D K + RR RERK E Q ++++ + E L+ + +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Query: 203 QTKLSREQIEGLIEDRRIH--LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQL 260
+ +E+ ++E+ ++ EE Q++ Q K +E + +E S + +
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 261 RSENQ----NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH--ESHHAQSEYI 314
R E Q +E+ ++ + + ++ ++Q +++E ++ + + E A E
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 315 KSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREI 355
+ + +L QE++ + + EE + R ++EE R++
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898
Score = 38.5 bits (88), Expect = 0.013
Identities = 73/378 (19%), Positives = 154/378 (40%), Gaps = 39/378 (10%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 83
+E E K+ E E + L + +L +E E + +L L++ EE+ E ++ ++
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL---LKREEEKRLEQERREQRLK 568
Query: 84 VCLFQEREHVLRLYSENDRLRIRE-----LEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
+ R+ +L+ E + R++ LE + K + + L + E +EP
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE- 627
Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSR-ERKESSEHYQRDIQTLILQVEALQ 197
++ Q + EQ E + + +RR R +R+E E ++ ++ + Q
Sbjct: 628 ----ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 198 AQLGEQTKLSREQIEGLIEDRRIHLEE----------IQVQHQRNQNKIKELTKNLHHTQ 247
E+ + +RE+I+ I + LE + + Q Q + +E + +
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Query: 248 ELLY--ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 305
L E + Q + E Q ++ +W + + + +Q R+ + P + E
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ-RLSAR----------PPLRE 792
Query: 306 SHHAQ--SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 363
Q +E + + + + E++ + Q E+EL + EEE ++R + +
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 364 GKRLQIMTKRYEALERRR 381
LQ +R + E+RR
Sbjct: 853 EDGLQEDQERRRSQEQRR 870
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 61.6 bits (148), Expect = 1e-09
Identities = 104/453 (22%), Positives = 194/453 (42%), Gaps = 67/453 (14%)
Query: 33 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL--FQER 90
K+++ E E L + LE KE E KLE +LQ+ +EE L + ++ ++ +
Sbjct: 605 KLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEAL 664
Query: 91 EHVLR-LYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAV 149
EH + L EN LR + L+ + + L + D ++ E V ++ T +
Sbjct: 665 EHESQGLQLENRTLR-KSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723
Query: 150 GECEQSES-------------SAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVE 194
+ E+ KA K S+R + S+E+ Q+ +++ + +
Sbjct: 724 AQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQ 783
Query: 195 ALQAQLG-------------EQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 241
L+++LG E +L+ Q+EG +DR+ LE+ Q ++++ +++ K
Sbjct: 784 TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKA-LEQEVAQLEKDKKLLEKEAK 842
Query: 242 NLHHTQEL----LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIG 297
L EL L +ST + E++ +K +D K+K + +K +
Sbjct: 843 RLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRD-AAGKLK----ELEKDNRDLT 897
Query: 298 KVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFK 357
K + V HA++ + +L++ LV EK S + L +EL E+ G+ RE+
Sbjct: 898 KQVTV-----HART--LTTLREDLVLEKLKSQQLSSELDKLSQEL----EKVGLNRELLL 946
Query: 358 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLE-QMLYKATVNARAN 416
+ +Y+ LE R KT + + +K+ LE QM KA++N +
Sbjct: 947 QEDDSGS------DTKYKILEGR---NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLE 997
Query: 417 QDLALL---CE-VRDSNRRAHKIQGELKNLKSK 445
+L +L CE +R + +Q K+ K
Sbjct: 998 SELQMLKKECETLRQNQGEGQHLQNSFKHPAGK 1030
Score = 58.2 bits (139), Expect = 2e-08
Identities = 110/473 (23%), Positives = 199/473 (42%), Gaps = 82/473 (17%)
Query: 12 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEE 71
S + + L + +LE K E E EN L KK+E + E + + DL+ EE
Sbjct: 474 SLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEE 533
Query: 72 -IAELQKALSDMQVC----------LFQEREHVLR-LYSENDRLRI---RELEDKKKIQN 116
I E ++ SDM+ L QE++H+ R ++S +R ++ ++D +K
Sbjct: 534 LIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENK 593
Query: 117 LLALVGTDA-GEVTYF-------------CKEPPHKVTILQKTIQAVGECEQSESSAFKA 162
L T+A G+++ KE + L++ +Q + Q E+ +
Sbjct: 594 ALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL----QEENG--RL 647
Query: 163 DPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL 222
K++ + E+ E+ EH + +Q L+ L+ L +S Q+EGL D +
Sbjct: 648 ARKVTSLETATEKVEALEHESQGLQ---LENRTLRKSLDTLQNVSL-QLEGLERDNK--- 700
Query: 223 EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKI 282
Q +++ L + + T STK Q+ ENQ E+ EK+ L +
Sbjct: 701 -----QLDAENLELRRLVETMRFT------STK-LAQMERENQQLER----EKEELRKNV 744
Query: 283 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 342
+ KK E L + ++S S ++ +Q+ S+ ++ Q +LE EL
Sbjct: 745 DLLKALGKKSER-----LELSYQS--------VSAENLRLQQSLESSSHKTQ--TLESEL 789
Query: 343 ARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 401
+ E + +RR++ + +L+ K +ALE+ EV + D K+L ++ K
Sbjct: 790 GELEAERQALRRDL--EALRLANAQLEGAEKDRKALEQ----EVAQLEKDKKLLEKEAKR 843
Query: 402 LEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 454
L Q + +A + A L V +R K ++ K+ LE + R
Sbjct: 844 LWQQV--ELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894
Score = 55.8 bits (133), Expect = 8e-08
Identities = 87/408 (21%), Positives = 168/408 (41%), Gaps = 50/408 (12%)
Query: 19 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 78
KLH +++Y+ +M E +N L++ + +E + + E+E +L+
Sbjct: 338 KLHD----VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393
Query: 79 LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 138
L D+++ +++ + L EN L I + + + +L E+ K
Sbjct: 394 LHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL-------GWELEQLSKNADLS 446
Query: 139 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 198
+ + + EC A +I K + +S+ RD +L+L+ L+
Sbjct: 447 DASRKSFVFELNEC---------ASSRILKLEKENQSLQSTIQGLRD-ASLVLEESGLKC 496
Query: 199 QLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL 258
GE K Q+ IE + LE + Q NQ+ ++ L++ L +E L D
Sbjct: 497 --GELEK-ENHQLSKKIEKLQTQLER---EKQSNQD-LETLSEELIREKEQL---QSDME 546
Query: 259 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK-------KKEDKIGKVLPVMHESHHAQS 311
L+++ + K EKD+L + R + + K +K K L + +
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKL 606
Query: 312 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 371
++ K +L ++ + + E+ LE EL R++EE G R + L+ T
Sbjct: 607 SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG--------RLARKVTSLETAT 658
Query: 372 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 419
++ EALE E +G + + + LR+ L L+ + + R N+ L
Sbjct: 659 EKVEALEH----ESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQL 702
Score = 42.0 bits (97), Expect = 0.001
Identities = 71/344 (20%), Positives = 135/344 (39%), Gaps = 39/344 (11%)
Query: 24 KELLEYYQKKMAECEAENEDLLKKLELYKEACE--------GQHKLECDLQQREEEIAEL 75
+E + + +M E + N L +L++ K+ CE GQH + A
Sbjct: 976 EEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASH 1035
Query: 76 Q------KALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 129
Q + + L + ++ + L N L+ + K+++Q+L T + ++
Sbjct: 1036 QGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQIL 1095
Query: 130 YFCKEPP----HKVTILQKT--IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 183
K+ H T+ +T +Q S+S+A A + + + + E+ E Q
Sbjct: 1096 TLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETEN-ESLQ 1154
Query: 184 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 243
R + L EAL E + L E + E + QH + +K L +NL
Sbjct: 1155 RQQEQLTAAYEALLQD--------HEHLGTLHERQSAEYEALIRQH----SCLKTLHRNL 1202
Query: 244 HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 303
+ L E D L+ ++E + +EK E++ L + + + + + G++ V
Sbjct: 1203 ELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVN 1262
Query: 304 HESHHAQSEY------IKSLKDKLVQEKKLSNMYQEQCISLEEE 341
H + EY K LK L + N +Q + L+E+
Sbjct: 1263 FLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQ 1306
Score = 33.9 bits (76), Expect = 0.31
Identities = 62/349 (17%), Positives = 145/349 (41%), Gaps = 22/349 (6%)
Query: 20 LHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQ--K 77
L S + + ++ E EAE + L + LE + A E D + E+E+A+L+ K
Sbjct: 775 LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDK 834
Query: 78 ALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGEVTYFCKEP- 135
L + + ++ + ++ ++ +E + + + LA AG++ K+
Sbjct: 835 KLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNR 894
Query: 136 --PHKVTILQKTIQAVGE--------CEQSESSAFKADPKISKRRPSRERKESSEHYQRD 185
+VT+ +T+ + E +Q S K ++ K +RE + D
Sbjct: 895 DLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSD 954
Query: 186 IQTLILQVEALQAQLGEQTKLSREQI---EGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 242
+ IL+ ++ L + E+I E +E++ +++ + Q + + + L +N
Sbjct: 955 TKYKILEGRN-ESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQN 1013
Query: 243 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS--KIKQYRVQCKKKEDKIGKVL 300
Q L + + +Q KE K+ M ++K ++ ++ +
Sbjct: 1014 QGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEK 1073
Query: 301 PVMHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREE 348
++ E H +++ + + +++ +K S QE +L+ + A+++ E
Sbjct: 1074 QLLKEQLQHLETQNV-TFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVE 1121
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,202,688
Number of Sequences: 37866
Number of extensions: 741422
Number of successful extensions: 6849
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 763
Number of HSP's that attempted gapping in prelim test: 3951
Number of HSP's gapped (non-prelim): 2378
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.