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Search of human proteins with 194294513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
(358 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 725 0.0
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 481 e-136
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 261 7e-70
gi|14042966 testis-specific serine kinase 6 [Homo sapiens] 240 1e-63
gi|42734401 testis-specific serine kinase 4 [Homo sapiens] 224 1e-58
gi|116256471 SNF1-like kinase [Homo sapiens] 197 2e-50
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 185 5e-47
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 184 1e-46
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 184 1e-46
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 184 1e-46
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 184 1e-46
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 183 2e-46
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 183 2e-46
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 183 2e-46
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 183 2e-46
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 183 2e-46
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 183 2e-46
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 182 3e-46
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 182 3e-46
gi|156105707 SNF related kinase [Homo sapiens] 182 5e-46
gi|156105705 SNF related kinase [Homo sapiens] 182 5e-46
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 175 5e-44
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 172 5e-43
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 167 1e-41
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 165 7e-41
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 161 1e-39
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 160 1e-39
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 160 2e-39
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 157 1e-38
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 156 3e-38
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 725 bits (1871), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE
Sbjct: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
Query: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL
Sbjct: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
Query: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 180
SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA
Sbjct: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 180
Query: 181 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 240
YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN
Sbjct: 181 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 240
Query: 241 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD 300
LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD
Sbjct: 241 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLD 300
Query: 301 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST 358
TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
Sbjct: 301 TKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST 358
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 481 bits (1238), Expect = e-136
Identities = 241/353 (68%), Positives = 281/353 (79%), Gaps = 20/353 (5%)
Query: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
MDDA VL+++GY++GINLG+GSYAKVKSAYSERLKFNVA+KIIDRKK P DF+E+FLPRE
Sbjct: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
Query: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
++ILA +NH SIIKTYEIFETS G++YI+MEL VQGDLLE IK +GALHED ARK F QL
Sbjct: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
Query: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 180
S A+KYCHDLD+VHRDLKC+NLLLDKDFNIKLSDF FSKRCLRD +GR+ LSKTFCGS A
Sbjct: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 180
Query: 181 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 240
YAAPEVLQ IPYQPKVYDIWSLGVILYIMVCGSMPYDDS+I+KMLRIQKEHRV+FPRSK+
Sbjct: 181 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 240
Query: 241 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAE---- 296
LT ECKDLIY MLQPDV++RLHIDEILSH W+Q PK + + S + +EGE E
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQ-PKARGSPSVAINKEGESSRGTEPLWT 299
Query: 297 ----------CKLDTKTGLRPDHRPDHK-----LGAKTQHRLLVVPENENRME 334
KL+ + +P +P+ K + Q +L P + ME
Sbjct: 300 PEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTME 352
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 261 bits (667), Expect = 7e-70
Identities = 125/266 (46%), Positives = 189/266 (71%), Gaps = 5/266 (1%)
Query: 7 LRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILAT 66
L GY +G +G+G+Y+KVK A+S++ + VA+K+ID+ P +F++RFLPRE+ I+ T
Sbjct: 5 LLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRT 64
Query: 67 VNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKY 126
++H +II+ YE+ E++DG+I ++MEL GD+ + + G L E A+ +FRQ+ A++Y
Sbjct: 65 LDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRY 124
Query: 127 CHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
CH + HRDLKCEN LL + FN+KL+DFGF+K + LS+TFCGS AYAAPEV
Sbjct: 125 CHGCGVAHRDLKCENALL-QGFNLKLTDFGFAKVLPKSHRE---LSQTFCGSTAYAAPEV 180
Query: 187 LQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECK 246
LQ IP+ K D+WS+GV+LY+M+C S+P+DD+DI KML Q++ V FP +++ +C+
Sbjct: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKML-WQQQKGVSFPTHLSISADCQ 239
Query: 247 DLIYRMLQPDVSQRLHIDEILSHSWL 272
DL+ R+L+PD+ R I+E+ H WL
Sbjct: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
Length = 273
Score = 240 bits (613), Expect = 1e-63
Identities = 127/274 (46%), Positives = 177/274 (64%), Gaps = 7/274 (2%)
Query: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
M +L + GY +G +G+GSY+KVK A S++ K VA+K++DR++ P DFV +FLPRE
Sbjct: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
Query: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
+ IL V H I+ +E E +G++YI+ME DLL+ ++ G + AR +F Q+
Sbjct: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI 119
Query: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFN-IKLSDFGFSKRCLRDSNGRIILSKTFCGSA 179
+ AV+Y HD +VHRDLKCEN+LL D +KL+DFGF R ++G LS T+CGSA
Sbjct: 120 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 175
Query: 180 AYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSK 239
AYA+PEVL IPY PK YD+WS+GV+LY+MV G MP+DDSDI + R QK V +P
Sbjct: 176 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQK-RGVLYPEGL 234
Query: 240 NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQ 273
L+ CK LI +LQ S R ++ + WL+
Sbjct: 235 ELSERCKALIAELLQFSPSARPSAGQVARNCWLR 268
>gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
Length = 328
Score = 224 bits (570), Expect = 1e-58
Identities = 123/287 (42%), Positives = 179/287 (62%), Gaps = 17/287 (5%)
Query: 5 TVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDIL 64
+++ + GY VG +G GSY V A+ + K VAVKII +KK D++ +FLPRE+ ++
Sbjct: 18 SLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVM 77
Query: 65 ATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAV 124
+ H +I Y E S R+YII+EL GD+LE+I+ GA E +A K F QL+ +
Sbjct: 78 KVLRHKYLINFYRAIE-STSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGI 136
Query: 125 KYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKR-----------CLRDSNGRIILSK 173
Y H IVHRDLK ENLLLDK N+K+SDFGF+K R N LS+
Sbjct: 137 AYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
Query: 174 TFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRV 233
T+CGS AYA PE+L+ +PY P + D WS+GVILY +V +P+DD++++K+LR + + V
Sbjct: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEV 255
Query: 234 DFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWL---QPPKP 277
FP + ++ ECK+LI +ML+ ++R I +I+ SW+ QP +P
Sbjct: 256 TFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWVLKFQPEQP 301
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 197 bits (500), Expect = 2e-50
Identities = 111/267 (41%), Positives = 163/267 (61%), Gaps = 9/267 (3%)
Query: 7 LRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILAT 66
LR Y + LGKG++A VK A K VA+KIID+ + + +E+ RE+ ++
Sbjct: 22 LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKL 80
Query: 67 VNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKY 126
+NH IIK Y++ ET D +YI+ E G++ +++ G L E+ ARK F Q+ SAV+Y
Sbjct: 81 LNHPHIIKLYQVMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139
Query: 127 CHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
CHD IVHRDLK ENLLLD + +IKL+DFGF +G + T+CGS YAAPEV
Sbjct: 140 CHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFY---KSGEPL--STWCGSPPYAAPEV 194
Query: 187 LQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECK 246
+ Y+ DIWSLGV+LY++VCGS+P+D ++ + + E R P ++ +C+
Sbjct: 195 FEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFF--MSQDCE 252
Query: 247 DLIYRMLQPDVSQRLHIDEILSHSWLQ 273
LI RML D ++R+ I +I H W++
Sbjct: 253 SLIRRMLVVDPARRITIAQIRQHRWMR 279
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 185 bits (470), Expect = 5e-47
Identities = 104/261 (39%), Positives = 155/261 (59%), Gaps = 9/261 (3%)
Query: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
Y + LGKG++A VK K VA+KIID+ + +E+ RE+ I+ ++H
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPH 78
Query: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
IIK Y++ ET +Y++ E G++ +++ G L+E AR+ F Q+ SAV YCH
Sbjct: 79 IIKLYQVMETKS-MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
Query: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
IVHRDLK ENLLLD + NIK++DFGF +G ++ T+CGS YAAPEV +
Sbjct: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFF---KSGELL--ATWCGSPPYAAPEVFEGQQ 192
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYR 251
Y+ DIWS+GV+LY++VCG++P+D + + + E R P ++ +C+ LI R
Sbjct: 193 YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYF--MSEDCEHLIRR 250
Query: 252 MLQPDVSQRLHIDEILSHSWL 272
ML D S+RL I +I H W+
Sbjct: 251 MLVLDPSKRLTIAQIKEHKWM 271
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 184 bits (467), Expect = 1e-46
Identities = 103/258 (39%), Positives = 160/258 (62%), Gaps = 15/258 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76
+GKG++AKVK A VA+KIID+ + PT + F RE+ I+ +NH +I+K +
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 119
Query: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136
E+ ET + +Y+IME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD
Sbjct: 120 EVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196
LK ENLLLD D NIK++DFGFS G++ TFCGS YAAPE+ Q Y
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKKYDGPE 233
Query: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ R L
Sbjct: 234 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLV 289
Query: 255 PDVSQRLHIDEILSHSWL 272
+ +R +++I+ W+
Sbjct: 290 LNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 184 bits (467), Expect = 1e-46
Identities = 103/258 (39%), Positives = 160/258 (62%), Gaps = 15/258 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76
+GKG++AKVK A VA+KIID+ + PT + F RE+ I+ +NH +I+K +
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 119
Query: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136
E+ ET + +Y+IME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD
Sbjct: 120 EVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196
LK ENLLLD D NIK++DFGFS G++ TFCGS YAAPE+ Q Y
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKKYDGPE 233
Query: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ R L
Sbjct: 234 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLV 289
Query: 255 PDVSQRLHIDEILSHSWL 272
+ +R +++I+ W+
Sbjct: 290 LNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 184 bits (467), Expect = 1e-46
Identities = 103/258 (39%), Positives = 160/258 (62%), Gaps = 15/258 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76
+GKG++AKVK A VA+KIID+ + PT + F RE+ I+ +NH +I+K +
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 119
Query: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136
E+ ET + +Y+IME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD
Sbjct: 120 EVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196
LK ENLLLD D NIK++DFGFS G++ TFCGS YAAPE+ Q Y
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKKYDGPE 233
Query: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ R L
Sbjct: 234 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLV 289
Query: 255 PDVSQRLHIDEILSHSWL 272
+ +R +++I+ W+
Sbjct: 290 LNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 184 bits (467), Expect = 1e-46
Identities = 103/258 (39%), Positives = 160/258 (62%), Gaps = 15/258 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76
+GKG++AKVK A VA+KIID+ + PT + F RE+ I+ +NH +I+K +
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 119
Query: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136
E+ ET + +Y+IME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD
Sbjct: 120 EVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196
LK ENLLLD D NIK++DFGFS G++ TFCGS YAAPE+ Q Y
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKKYDGPE 233
Query: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ R L
Sbjct: 234 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLV 289
Query: 255 PDVSQRLHIDEILSHSWL 272
+ +R +++I+ W+
Sbjct: 290 LNPIKRGTLEQIMKDRWI 307
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 183 bits (465), Expect = 2e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
Query: 256 DVSQRLHIDEILSHSWL 272
+ S+R +++I+ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 183 bits (465), Expect = 2e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
Query: 256 DVSQRLHIDEILSHSWL 272
+ S+R +++I+ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 183 bits (465), Expect = 2e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
Query: 256 DVSQRLHIDEILSHSWL 272
+ S+R +++I+ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 183 bits (465), Expect = 2e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 117
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 118 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 176
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 177 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 287
Query: 256 DVSQRLHIDEILSHSWL 272
+ S+R +++I+ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 183 bits (465), Expect = 2e-46
Identities = 99/257 (38%), Positives = 159/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VAVKIID+ + + +++ RE+ I+ +NH +I+K +E
Sbjct: 26 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPNIVKLFE 84
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRDL
Sbjct: 85 VIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDL 143
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 144 KAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKKYDGPEV 198
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ + L
Sbjct: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKFLIL 254
Query: 256 DVSQRLHIDEILSHSWL 272
+ S+R +++I+ W+
Sbjct: 255 NPSKRGTLEQIMKDRWM 271
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 183 bits (465), Expect = 2e-46
Identities = 100/264 (37%), Positives = 163/264 (61%), Gaps = 13/264 (4%)
Query: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
Y + +GKG++A VK A K VA+KIID+ + + +++ RE+ I+ + H
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Query: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
II+ Y++ ET + IY++ E G++ + + G + E AR+ F+Q+ +AV +CH +
Sbjct: 67 IIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
Query: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
IVHRDLK ENLLLD + NIK++DFGFS + G+++ KT+CGS YAAPE+ +
Sbjct: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLF---TPGQLL--KTWCGSPPYAAPELFEGKE 180
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLI 249
Y DIWSLGV+LY++VCG++P+D S ++ + + + R+ F ++ EC+ LI
Sbjct: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF----FMSTECEHLI 236
Query: 250 YRMLQPDVSQRLHIDEILSHSWLQ 273
ML D ++RL +++I H W++
Sbjct: 237 RHMLVLDPNKRLSMEQICKHKWMK 260
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 182 bits (463), Expect = 3e-46
Identities = 101/258 (39%), Positives = 159/258 (61%), Gaps = 15/258 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76
+GKG++AKVK A VAVKIID+ + PT + F RE+ I+ +NH +I+K +
Sbjct: 66 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 123
Query: 77 EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136
E+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV+YCH IVHRD
Sbjct: 124 EVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRD 182
Query: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196
LK ENLLLD D NIK++DFGFS + TFCGS YAAPE+ Q Y
Sbjct: 183 LKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQGKKYDGPE 237
Query: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254
D+WSLGVILY +V GS+P+D +++++ ++ ++R+ F ++ +C++L+ ++L
Sbjct: 238 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKKLLV 293
Query: 255 PDVSQRLHIDEILSHSWL 272
+ +R +++I+ W+
Sbjct: 294 LNPIKRGSLEQIMKDRWM 311
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 182 bits (463), Expect = 3e-46
Identities = 99/257 (38%), Positives = 157/257 (61%), Gaps = 13/257 (5%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
+GKG++AKVK A VA+KIID+ + +++ RE+ I+ +NH +I+K +E
Sbjct: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPNIVKLFE 123
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV YCH +IVHRDL
Sbjct: 124 VIET-EKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDL 182
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD + NIK++DFGFS S TFCGS YAAPE+ Q Y
Sbjct: 183 KAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKKYDGPEV 237
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
DIWSLGVILY +V GS+P+D +++++ ++ ++RV F ++ +C+ ++ R L
Sbjct: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----YMSTDCESILRRFLVL 293
Query: 256 DVSQRLHIDEILSHSWL 272
+ ++R +++I+ W+
Sbjct: 294 NPAKRCTLEQIMKDKWI 310
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 182 bits (461), Expect = 5e-46
Identities = 111/279 (39%), Positives = 167/279 (59%), Gaps = 19/279 (6%)
Query: 9 KKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
K+GY I G+ LG+G +A VK A VAVK+ID+ K T L +E
Sbjct: 5 KRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQE 63
Query: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHEDVARKMFRQ 119
+ + V H +I++ YE+ +T ++Y+I+ELG GD+ ++I K + L+ED+A+K F Q
Sbjct: 64 VRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
Query: 120 LSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
+ A+ YCH L +VHRDLK EN++ +K +KL+DFGFS + G+ + T CGS
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGS 177
Query: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRS 238
AY+APE+L Y DIWSLGVIL+++VCG P+ +++ + L + + + P
Sbjct: 178 LAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP-- 235
Query: 239 KNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKP 277
+++ ECKDLI RMLQ D +R ++EI +H WLQ P
Sbjct: 236 SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 274
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 182 bits (461), Expect = 5e-46
Identities = 111/279 (39%), Positives = 167/279 (59%), Gaps = 19/279 (6%)
Query: 9 KKGY---IVGI-----NLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
K+GY I G+ LG+G +A VK A VAVK+ID+ K T L +E
Sbjct: 5 KRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQE 63
Query: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFI-KCQGALHEDVARKMFRQ 119
+ + V H +I++ YE+ +T ++Y+I+ELG GD+ ++I K + L+ED+A+K F Q
Sbjct: 64 VRCMKLVQHPNIVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122
Query: 120 LSSAVKYCHDLDIVHRDLKCENLLL-DKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGS 178
+ A+ YCH L +VHRDLK EN++ +K +KL+DFGFS + G+ + T CGS
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGS 177
Query: 179 AAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRS 238
AY+APE+L Y DIWSLGVIL+++VCG P+ +++ + L + + + P
Sbjct: 178 LAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP-- 235
Query: 239 KNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKP 277
+++ ECKDLI RMLQ D +R ++EI +H WLQ P
Sbjct: 236 SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 274
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 175 bits (444), Expect = 5e-44
Identities = 102/264 (38%), Positives = 150/264 (56%), Gaps = 9/264 (3%)
Query: 9 KKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVN 68
K Y + LGKG+Y KVK A VA+K I + K + + RE++I++++N
Sbjct: 52 KHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN 111
Query: 69 HGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCH 128
H II YE+FE D +I IIME +G+L ++I + L E R FRQ+ SAV YCH
Sbjct: 112 HPHIISIYEVFENKD-KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCH 170
Query: 129 DLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQ 188
+VHRDLK EN+LLD + NIK++DFG S +D +TFCGS YA+PE++
Sbjct: 171 KNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDK-----FLQTFCGSPLYASPEIVN 225
Query: 189 SIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDL 248
PY+ D W+LGV+LY +V G+MP+D D + ++R P + + + L
Sbjct: 226 GRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS---DARGL 282
Query: 249 IYRMLQPDVSQRLHIDEILSHSWL 272
I ML + +R I++I +H W+
Sbjct: 283 IRWMLMVNPDRRATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 172 bits (435), Expect = 5e-43
Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 10/301 (3%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
LGKG+Y KVK A + VA+K I + K + + RE++I++++NH II +E
Sbjct: 59 LGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHE 117
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
+FE S +I I+ME +GDL ++I + L E AR FRQ+ SAV YCH +VHRDL
Sbjct: 118 VFENSS-KIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDL 176
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K EN+LLD + NIK++DFG S G+ + +TFCGS YA+PE++ PY
Sbjct: 177 KLENILLDANGNIKIADFGLSNLY---HQGKFL--QTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDV 257
D WSLGV+LYI+V G+MP+D D + +++ P + C LI +L +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC---GLIRWLLMVNP 288
Query: 258 SQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGA 317
++R ++++ SH W+ EG + LR RP + GA
Sbjct: 289 TRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGA 348
Query: 318 K 318
K
Sbjct: 349 K 349
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 167 bits (424), Expect = 1e-41
Identities = 103/267 (38%), Positives = 146/267 (54%), Gaps = 8/267 (2%)
Query: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
YI+G LG G++ KVK E VAVKI++R+K + V + RE+ L H
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
IIK Y++ T I+++ME G+L ++I G L E +R++F+Q+ S V YCH
Sbjct: 87 IIKLYQVISTPSD-IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
Query: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
+VHRDLK EN+LLD N K++DFG S S+G + +T CGS YAAPEV+
Sbjct: 146 VVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFL--RTSCGSPNYAAPEVISGRL 200
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYR 251
Y DIWS GVILY ++CG++P+DD + + + K F + L L+
Sbjct: 201 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK--KICDGIFYTPQYLNPSVISLLKH 258
Query: 252 MLQPDVSQRLHIDEILSHSWLQPPKPK 278
MLQ D +R I +I H W + PK
Sbjct: 259 MLQVDPMKRATIKDIREHEWFKQDLPK 285
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 165 bits (417), Expect = 7e-41
Identities = 100/266 (37%), Positives = 145/266 (54%), Gaps = 8/266 (3%)
Query: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
Y++G LG G++ KVK + VAVKI++R+K + V + RE+ L H
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75
Query: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
IIK Y++ T +++ME G+L ++I G + E AR++F+Q+ SAV YCH
Sbjct: 76 IIKLYQVISTPTD-FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
Query: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
+VHRDLK EN+LLD N K++DFG S S+G + +T CGS YAAPEV+
Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFL--RTSCGSPNYAAPEVISGRL 189
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYR 251
Y DIWS GVILY ++CG++P+DD + + + K F + L L+
Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK--KIRGGVFYIPEYLNRSVATLLMH 247
Query: 252 MLQPDVSQRLHIDEILSHSWLQPPKP 277
MLQ D +R I +I H W + P
Sbjct: 248 MLQVDPLKRATIKDIREHEWFKQDLP 273
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 161 bits (407), Expect = 1e-39
Identities = 90/254 (35%), Positives = 149/254 (58%), Gaps = 9/254 (3%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
LGKG VK VA+KI++R+K + + + RE+ IL + H ++K ++
Sbjct: 25 LGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHD 83
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
++E +Y+++E G+L +++ +G L ARK FRQ+ SA+ +CH I HRDL
Sbjct: 84 VYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDL 142
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD+ NI+++DFG + + DS L +T CGS YA PEV++ Y +
Sbjct: 143 KPENLLLDEKNNIRIADFGMASLQVGDS-----LLETSCGSPHYACPEVIRGEKYDGRKA 197
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDV 257
D+WS GVIL+ ++ G++P+DD ++R++L +K R F + +C+ L+ M++ D
Sbjct: 198 DVWSCGVILFALLVGALPFDDDNLRQLL--EKVKRGVFHMPHFIPPDCQSLLRGMIEVDA 255
Query: 258 SQRLHIDEILSHSW 271
++RL ++ I H W
Sbjct: 256 ARRLTLEHIQKHIW 269
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 160 bits (406), Expect = 1e-39
Identities = 94/266 (35%), Positives = 149/266 (56%), Gaps = 14/266 (5%)
Query: 10 KGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPR---EMDILAT 66
K Y + +G G +AKVK A VA+KI+D+ +D LPR E++ L
Sbjct: 9 KYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-----LPRIKTEIEALKN 63
Query: 67 VNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKY 126
+ H I + Y + ET++ +I++++E G+L ++I Q L E+ R +FRQ+ SAV Y
Sbjct: 64 LRHQHICQLYHVLETAN-KIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAY 122
Query: 127 CHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEV 186
H HRDLK ENLL D+ +KL DFG C + + +T CGS AYAAPE+
Sbjct: 123 VHSQGYAHRDLKPENLLFDEYHKLKLIDFGL---CAKPKGNKDYHLQTCCGSLAYAAPEL 179
Query: 187 LQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECK 246
+Q Y D+WS+G++LY+++CG +P+DD ++ + + + D P K L+
Sbjct: 180 IQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVP--KWLSPSSI 237
Query: 247 DLIYRMLQPDVSQRLHIDEILSHSWL 272
L+ +MLQ D +R+ + +L+H W+
Sbjct: 238 LLLQQMLQVDPKKRISMKNLLNHPWI 263
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 160 bits (404), Expect = 2e-39
Identities = 89/254 (35%), Positives = 149/254 (58%), Gaps = 9/254 (3%)
Query: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
LGKG VK VA+KI++R+K + + + RE+ IL + H ++K ++
Sbjct: 40 LGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPHVLKLHD 98
Query: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
++E +Y+++E G+L +++ +G L ARK FRQ+ SA+ +CH I HRDL
Sbjct: 99 VYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDL 157
Query: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
K ENLLLD+ NI+++DFG + + DS L +T CGS YA PEV++ Y +
Sbjct: 158 KPENLLLDEKNNIRIADFGMASLQVGDS-----LLETSCGSPHYACPEVIKGEKYDGRRA 212
Query: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDV 257
D+WS GVIL+ ++ G++P+DD ++R++L +K R F + +C+ L+ M++ +
Sbjct: 213 DMWSCGVILFALLVGALPFDDDNLRQLL--EKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
Query: 258 SQRLHIDEILSHSW 271
+RL +++I H W
Sbjct: 271 EKRLSLEQIQKHPW 284
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 157 bits (398), Expect = 1e-38
Identities = 103/282 (36%), Positives = 146/282 (51%), Gaps = 23/282 (8%)
Query: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
YI+G LG G++ KVK E VAVKI++R+K + V + RE+ L H
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGA---------------LHEDVARKM 116
IIK Y++ T I+++ME G+L ++I G L E +R++
Sbjct: 87 IIKLYQVISTPSD-IFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145
Query: 117 FRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFC 176
F+Q+ S V YCH +VHRDLK EN+LLD N K++DFG S S+G + +T C
Sbjct: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFL--RTSC 200
Query: 177 GSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFP 236
GS YAAPEV+ Y DIWS GVILY ++CG++P+DD + + + K F
Sbjct: 201 GSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK--KICDGIFY 258
Query: 237 RSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPK 278
+ L L+ MLQ D +R I +I H W + PK
Sbjct: 259 TPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 300
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 156 bits (394), Expect = 3e-38
Identities = 102/272 (37%), Positives = 155/272 (56%), Gaps = 15/272 (5%)
Query: 8 RKKGYIVGIN-LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTD-FVERFLPREMDILA 65
R Y++G LG+GS+AKV+ VA+K+ID+K+ D +V + L RE I
Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
Query: 66 TVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVK 125
+ H +I + +I ET + Y++MEL G+L+ I + L E AR+ RQL SAV+
Sbjct: 117 MIRHPNITQLLDILETENS-YYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVE 175
Query: 126 YCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTF---CGSAAYA 182
+ H +VHRDLK ENLLLD+D NIKL DFG S + G + S F CGS AYA
Sbjct: 176 HLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLS-----NCAGILGYSDPFSTQCGSPAYA 230
Query: 183 APEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPY--DDSDIRKMLRIQKEHRVDFPRSKN 240
APE+L Y PK+ D+WS+GV +Y M+ G++P+ + +R + + + ++ P
Sbjct: 231 APELLARKKYGPKI-DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMN-PLPTQ 288
Query: 241 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
L+ + +L+PD +R +I + L++ WL
Sbjct: 289 LSTGAISFLRSLLEPDPVKRPNIQQALANRWL 320
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,430,350
Number of Sequences: 37866
Number of extensions: 592720
Number of successful extensions: 3430
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 697
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 1275
Number of HSP's gapped (non-prelim): 939
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.