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Search of human proteins with 194097365
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097365 FtsJ homolog 3 [Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097365 FtsJ homolog 3 [Homo sapiens] 1669 0.0
gi|29029591 FtsJ homolog 1 isoform b [Homo sapiens] 161 3e-39
gi|29029589 FtsJ homolog 1 isoform b [Homo sapiens] 161 3e-39
gi|7110661 FtsJ homolog 1 isoform a [Homo sapiens] 158 2e-38
gi|7019377 FtsJ homolog 2 [Homo sapiens] 102 1e-21
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 63 1e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 2e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 2e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 2e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 2e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 2e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 2e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 2e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 2e-07
gi|148746195 trichohyalin [Homo sapiens] 55 3e-07
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 50 1e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 49 2e-05
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 49 2e-05
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 48 3e-05
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 48 3e-05
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 48 3e-05
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 48 4e-05
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 48 4e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 47 6e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 47 6e-05
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 47 6e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 46 1e-04
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 46 1e-04
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 46 1e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 46 1e-04
>gi|194097365 FtsJ homolog 3 [Homo sapiens]
Length = 847
Score = 1669 bits (4322), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQ 60
MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQ
Sbjct: 1 MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQ 60
Query: 61 VAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAP 120
VAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAP
Sbjct: 61 VAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAP 120
Query: 121 NVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQA 180
NVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQA
Sbjct: 121 NVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQA 180
Query: 181 TKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEG 240
TKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEG
Sbjct: 181 TKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEG 240
Query: 241 YAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVL 300
YAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVL
Sbjct: 241 YAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVL 300
Query: 301 GRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEE 360
GRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEE
Sbjct: 301 GRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEE 360
Query: 361 EEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGM 420
EEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGM
Sbjct: 361 EEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGM 420
Query: 421 FSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAG 480
FSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAG
Sbjct: 421 FSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAG 480
Query: 481 VRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIED 540
VRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIED
Sbjct: 481 VRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIED 540
Query: 541 DADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSG 600
DADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSG
Sbjct: 541 DADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSG 600
Query: 601 TEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKH 660
TEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKH
Sbjct: 601 TEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKH 660
Query: 661 RILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVG 720
RILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVG
Sbjct: 661 RILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVG 720
Query: 721 KKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVA 780
KKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVA
Sbjct: 721 KKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVA 780
Query: 781 QLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQ 840
QLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQ
Sbjct: 781 QLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQ 840
Query: 841 KKKHKRK 847
KKKHKRK
Sbjct: 841 KKKHKRK 847
>gi|29029591 FtsJ homolog 1 isoform b [Homo sapiens]
Length = 327
Score = 161 bits (407), Expect = 3e-39
Identities = 92/234 (39%), Positives = 128/234 (54%), Gaps = 6/234 (2%)
Query: 5 GKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAK 64
G+ K +RD +Y LAKE G+R+RSAFKL+QL++ FQ Q +DLCAAPG W QV ++
Sbjct: 2 GRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQ 61
Query: 65 FM--PVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAPNV 122
+ S +V VDL + PLP VV +Q DIT + + + K D+V+ DGAP+V
Sbjct: 62 KIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDV 121
Query: 123 GASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATK 182
D Y QA L L AL +A L GG F+ K+FR RD L Q F V K
Sbjct: 122 TGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAK 181
Query: 183 PQASRHESAEIFVVCQGFLAPD----KVDSKFFDPKFAFKEVEVQAKTVTELVT 232
P++SR+ S E F VCQG+ P+ + D + F +++ + + VT
Sbjct: 182 PRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDFNQLDGPTRIIVPFVT 235
>gi|29029589 FtsJ homolog 1 isoform b [Homo sapiens]
Length = 327
Score = 161 bits (407), Expect = 3e-39
Identities = 92/234 (39%), Positives = 128/234 (54%), Gaps = 6/234 (2%)
Query: 5 GKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAK 64
G+ K +RD +Y LAKE G+R+RSAFKL+QL++ FQ Q +DLCAAPG W QV ++
Sbjct: 2 GRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQ 61
Query: 65 FM--PVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAPNV 122
+ S +V VDL + PLP VV +Q DIT + + + K D+V+ DGAP+V
Sbjct: 62 KIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDV 121
Query: 123 GASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATK 182
D Y QA L L AL +A L GG F+ K+FR RD L Q F V K
Sbjct: 122 TGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAK 181
Query: 183 PQASRHESAEIFVVCQGFLAPD----KVDSKFFDPKFAFKEVEVQAKTVTELVT 232
P++SR+ S E F VCQG+ P+ + D + F +++ + + VT
Sbjct: 182 PRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDFNQLDGPTRIIVPFVT 235
>gi|7110661 FtsJ homolog 1 isoform a [Homo sapiens]
Length = 329
Score = 158 bits (399), Expect = 2e-38
Identities = 88/202 (43%), Positives = 117/202 (57%), Gaps = 2/202 (0%)
Query: 5 GKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAK 64
G+ K +RD +Y LAKE G+R+RSAFKL+QL++ FQ Q +DLCAAPG W QV ++
Sbjct: 2 GRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLSQ 61
Query: 65 FM--PVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQALRKELKTWKVDVVLNDGAPNV 122
+ S +V VDL + PLP VV +Q DIT + + + K D+V+ DGAP+V
Sbjct: 62 KIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPDV 121
Query: 123 GASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATK 182
D Y QA L L AL +A L GG F+ K+FR RD L Q F V K
Sbjct: 122 TGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCAK 181
Query: 183 PQASRHESAEIFVVCQGFLAPD 204
P++SR+ S E F VCQG+ P+
Sbjct: 182 PRSSRNSSIEAFAVCQGYDPPE 203
>gi|7019377 FtsJ homolog 2 [Homo sapiens]
Length = 246
Score = 102 bits (254), Expect = 1e-21
Identities = 68/192 (35%), Positives = 97/192 (50%), Gaps = 9/192 (4%)
Query: 12 RDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKFMPVS-- 69
RD F AK YR RSAFKL+++N R Q L+ +LD AAPG W QVA + + +
Sbjct: 40 RDPFVKAAKVESYRCRSAFKLLEVNERHQILRPGLRVLDCGAAPGAWSQVAVQKVNAAGT 99
Query: 70 ------SLIVGVDLVPIKPLPNVVTL-QQDITTERCRQALRKELKTWKVDVVLNDGAPNV 122
++GVDL+ I PL L D+T R Q + + L + DV+L+D APN
Sbjct: 100 DPSSPVGFVLGVDLLHIFPLEGATFLCPADVTDPRTSQRILEVLPGRRADVILSDMAPNA 159
Query: 123 GASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFRSRDYQPLLWIFQQLFRRVQATK 182
D L L L + D L GG+F+ K + + L + F+ V+ K
Sbjct: 160 TGFRDLDHDRLISLCLTLLSVTPDILQPGGTFLCKTWAGSQSRRLQRRLTEEFQNVRIIK 219
Query: 183 PQASRHESAEIF 194
P+ASR ES+E++
Sbjct: 220 PEASRKESSEVY 231
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 63.2 bits (152), Expect = 1e-09
Identities = 79/355 (22%), Positives = 149/355 (41%), Gaps = 54/355 (15%)
Query: 310 NWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLN 369
N+ K +Y K K+ AK S + ED D + + K K++++++ ++
Sbjct: 275 NYSLKYTKYTKKDTKKNAKK---SSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTE 331
Query: 370 QTLAEM--KAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIR 427
T AE E + K+ KKKL ++ +K+ + P + + G+ +
Sbjct: 332 STDAESGDSKDERKDTKKDKKKLKKDDKKKDTK-----KYPESTDTESGD----AKDARN 382
Query: 428 GHQLLEEVTQGDMSAAD----TFLSDLPRDDIYVSDVEDD----------------GDDT 467
+ L++ ++ D D TF +D + +D+ D+
Sbjct: 383 DSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEE 442
Query: 468 SLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQAN 527
S D+D +P+ +G +D+K+ + +DDK+++ ++N +E L++++ +
Sbjct: 443 STDADSEPKG----DSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH 498
Query: 528 LWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLY 587
KGS I+ DA + E + A+ E+ + G + K + TE LY
Sbjct: 499 SKEKKGSKKDIKKDARKDTESTDAE-FDESSKTGFKTSTKIKGSD-------TESEESLY 550
Query: 588 QDEAPKGTEASSGTEAATGLEG-EEKDGISDSDSSTSSEEEESWEPLRGKKRSRG 641
+ A K + S GT A + +EG E K G S T+ E +G+K S G
Sbjct: 551 KPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNE-------KGEKASTG 598
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1731 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1783
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1842 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1896
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1897 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1536
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1597 QEE-----HVAVAQLREEAERRAQQQAEAER 1622
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1623
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1624 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1675 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1783
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1784 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1881 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2235
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2288
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2407
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTL 2434
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2308
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2419
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2420 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2475
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2476 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2522
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 567 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 618
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 619 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 673
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 674 ELQNAGDRLLREDHPARPTVE 694
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1555 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1735 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1787
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1846 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1900
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1901 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1540
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1601 QEE-----HVAVAQLREEAERRAQQQAEAER 1626
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1627
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1628 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1679 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1728
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1787
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1788 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1892
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1885 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2239
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2292
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2352
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2411
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTLVQTL 2438
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2312
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2423
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2424 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2479
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2480 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2526
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 571 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 622
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 623 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 677
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 678 ELQNAGDRLLREDHPARPTVE 698
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1731 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1783
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1842 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1896
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1897 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1536
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1597 QEE-----HVAVAQLREEAERRAQQQAEAER 1622
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1623
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1624 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1675 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1783
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1784 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1881 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2235
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2288
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2407
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTL 2434
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2308
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2419
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2420 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2475
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2476 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2522
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 567 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 618
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 619 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 673
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 674 ELQNAGDRLLREDHPARPTVE 694
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1519 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1699 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1751
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1810 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1864
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1865 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1504
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1565 QEE-----HVAVAQLREEAERRAQQQAEAER 1590
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1591
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1592 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1643 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1692
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1751
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1752 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1856
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1849 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2203
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2256
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2316
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2375
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTLVQTL 2402
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2276
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2387
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2388 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2443
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2444 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2490
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 535 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 586
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 587 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 641
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 642 ELQNAGDRLLREDHPARPTVE 662
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1688 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1868 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1920
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1979 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 2033
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 2034 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1673
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1734 QEE-----HVAVAQLREEAERRAQQQAEAER 1759
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1760
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1761 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1812 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1861
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1920
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1921 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 2025
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 2018 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2372
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2425
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2485
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2544
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTL 2571
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2445
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2556
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2557 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2612
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2613 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2659
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 704 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 755
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 756 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 810
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 811 ELQNAGDRLLREDHPARPTVE 831
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1529 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1709 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1761
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1820 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1874
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1875 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1514
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1575 QEE-----HVAVAQLREEAERRAQQQAEAER 1600
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1601
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1602 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1653 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1702
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1761
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1762 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1866
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1859 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2213
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2266
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2326
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2385
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2386 KQAEEIGEKLHRTELATQEKVTLVQTL 2412
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2286
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2287 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2397
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2398 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2453
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2454 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2500
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 545 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 596
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 597 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 651
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 652 ELQNAGDRLLREDHPARPTVE 672
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1537 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1717 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1769
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1828 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1882
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1883 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1522
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1583 QEE-----HVAVAQLREEAERRAQQQAEAER 1608
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1609
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1610 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1661 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1710
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1769
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1770 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1874
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1867 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2221
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2274
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2275 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2334
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2393
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2394 KQAEEIGEKLHRTELATQEKVTLVQTL 2420
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2294
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2295 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2405
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2406 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2461
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2462 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2508
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 553 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 604
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 605 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 659
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 660 ELQNAGDRLLREDHPARPTVE 680
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.5 bits (132), Expect = 2e-07
Identities = 109/527 (20%), Positives = 215/527 (40%), Gaps = 50/527 (9%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ ++ ++ AL+ + S E + + S A T Q + +EE + A
Sbjct: 1578 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
Query: 374 EMKAQEVAELKRKKKKLLRE----QRKQRERVELKMDLPGV----SIA--------DEGE 417
E +AQ+ AE +R +++ RE Q K E + L++ V S+A +E E
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 418 -----TGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
G +R +L E+ + A+ + + + + +
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
L EELA ++ QKR L E + K E E V L KA +EE + S+
Sbjct: 1758 LLEEELARLQREAAAATQKRQEL-EAELAKVRAEME----VLLASKARAEEESRST--SE 1810
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP 592
S +E +A E+++ R + ++++QL + + + E L + A
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 593 KGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIV 652
G TEA L+ +E ++++ E+E+++ R ++++ K+D + +
Sbjct: 1869 IGEATRLKTEAEIALKEKE----AENERLRRLAEDEAFQRRRLEEQAAQHKADIEE-RLA 1923
Query: 653 PIEDPAKHRILDPEGLALGAVIASSKKAKRDL--IDNSFNRYTFNEDEGELPEWFVQEEK 710
+ + + +GL + + ++ + ++ + SF + + E EL ++
Sbjct: 1924 QLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982
Query: 711 QHRIRQLPVGKKEVEHYR-------KRWREINARPIKKVA--EAKARKKRRMLKRLEQTR 761
+ +R + E R +R RE R K +A E AR+++ L+ +E+ +
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042
Query: 762 KKAEAVVNTVDISEREKVAQL---RSLYKKAGLGKEKRHVTYVVAKK 805
K E + +E+E QL + +K +EK H V K+
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 16/151 (10%)
Query: 697 DEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREIN-ARPIKKVAEAKARKKRRMLK 755
+E E + QEE + RQ+ + E RKR E+ A +K AEA AR+K+R L+
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVELASRVKAEAEA-AREKQRALQ 1563
Query: 756 RLEQTRKKAEAVVNTVDISEREKVAQ----LRSLYKKAGLGKEKRHVTYVVAKKGVGRKV 811
LE+ R +AE + +E E+ Q L + + A + + ++ + R +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 812 RRPAGVRGHFKVVDSRMKKDQRAQQRKEQKK 842
+ H V R + ++RAQQ+ E ++
Sbjct: 1624 QEE-----HVAVAQLREEAERRAQQQAEAER 1649
Score = 40.0 bits (92), Expect = 0.009
Identities = 108/586 (18%), Positives = 223/586 (38%), Gaps = 100/586 (17%)
Query: 328 KALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK--- 384
K + +L EE+E E A ++ ++ E E++ QL + A+ KAQ E K
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421
Query: 385 -RKKKKLLREQR----KQRERVELKMDLPGVSIADEGE-------------TGMFSLSTI 426
R +++++R + Q+++ ++ +L + + E E + + I
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 427 RGHQLLEEVTQGDMSAADTFLSDL---------------PRDDIYVSDVEDDGD-----D 466
R +L E T+ A+ L L + V+D+ +
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 467 TSLDSDLDPEELAGVRGHQGLR--DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEE 524
L S + E A + L+ ++ R++ E + + E E V + + +
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601
Query: 525 QANLWFSKGSFAGIEDDADEALE---ISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTE 581
+A L + SFA + +L+ ++ AQL E R+ +QQ + ++
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA----------- 1650
Query: 582 IMSPLYQDEAPKGTE---ASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKR 638
++EA + E + L+ EE ++ S +E E+ E + R
Sbjct: 1651 ------REEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 639 SRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE 698
RG E + R L + L +A +R + R ++
Sbjct: 1702 RRGKAE----------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1751
Query: 699 GELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLE 758
GE ++EE R+ ++ + ++ A ++ + +KAR + E
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE-MEVLLASKARAEEESRSTSE 1810
Query: 759 QTRKKAEAVVNTVDISEREKVAQLRSLYKKA---------GLGKEKRHVTYVVAKK---- 805
+++++ EA E+ A+LR+L ++A +++ V+A+K
Sbjct: 1811 KSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 806 GVGRKVRRPAGVRGHFKVVDS----RMKKDQRAQQRK--EQKKKHK 845
G +++ A + K ++ R+ +D+ Q+R+ EQ +HK
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1915
Score = 35.8 bits (81), Expect = 0.17
Identities = 115/567 (20%), Positives = 229/567 (40%), Gaps = 71/567 (12%)
Query: 277 DEELAQHPATTEDIRVCCQDIRVLGRKEL---RSLLNWRTKLRRYVAKKLK------EQA 327
+E+ AQH A DI +R EL + L+ + RR V +++ E+A
Sbjct: 1908 EEQAAQHKA---DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 328 KA----LDISL----SSGEEDEGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLA-- 373
A L++ L S+ E+ +E + +Q EEE E EE++ ++LA
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024
Query: 374 -----EMKA--QEVAELKRK--KKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLS 424
+ KA +EV LK K + + LRE+ +Q +L++ + E + +
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 425 TIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVED---DGDDTSLDSDLDPEELAGV 481
+ Q L++ Q + S D + + E+ + + S EE +
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144
Query: 482 RGHQGLRDQKRMRLTEVQDD-KEEEEEENPLLVPLEEKAVLQEEQANLWFSK-GSFA--G 537
+ + Q R + + ++E E+E E+ A+ Q++ A+ K FA
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Query: 538 IEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGT 595
+ A E++ +L E + +K ++ Q+L + S + ++
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR--SQVEEELFSVRV 2262
Query: 596 EASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIE 655
+ ++ +E E + I +T +E E ++ S V +
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS-------VAAQ 2315
Query: 656 DPAKHRILDPEGLALGAVIASSK-KAKRDLIDNSFN---RYTFNEDEGELPE---WFVQE 708
+ A+ R L E LA +A K K + + + + EL + +QE
Sbjct: 2316 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2375
Query: 709 EKQHRIRQLPVG----KKEVEHYRKRWREINARPIK---KVAEAKARKKRRMLKRLEQTR 761
+K+ +QL ++ +E R+R E++A + +VAE +R + R + ++ R
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFR 2434
Query: 762 KKAEAV---VNTVDISEREKVAQLRSL 785
K+AE + ++ +++ +EKV +++L
Sbjct: 2435 KQAEEIGEKLHRTELATQEKVTLVQTL 2461
Score = 34.7 bits (78), Expect = 0.38
Identities = 104/522 (19%), Positives = 208/522 (39%), Gaps = 64/522 (12%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDS---TAGTTKQPSKEEEE--------E 362
KLR+ ++ +A+A +L + + + E T +Q ++ E+E E
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Query: 363 EEEEQ---LNQTLAEMKAQ--EVAELKRKKKKLLREQRKQRE-----RVELKMDLPGVSI 412
E + Q L++ L +KA+ E A + + ++ L R Q E + ++ + + +
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 413 ADEGETGMFSLSTI-RGHQLLEEVTQGDMSAADTF-LSDLPRDDIYVSDVEDDGDDTSLD 470
D+ T F + Q+ EE + ++A + L L +D+ +L
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL--------AQQRALA 2335
Query: 471 SDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF 530
+ E++ V+ L+ + + +Q KE +E+ L +E+ Q + F
Sbjct: 2336 EKMLKEKMQAVQEATRLKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391
Query: 531 SKGSFAGIEDDADEALEISQAQLLFE--NRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQ 588
+ A + + + E + +L +R + R ++ Q+ + EI L++
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHR 2446
Query: 589 DEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDG 648
E T+ ++ ++ D ++ +E E E L+ + + KS++
Sbjct: 2447 TEL--ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE-- 2502
Query: 649 FEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQE 708
++ + ++L E AL S K D+ R F E E E Q+
Sbjct: 2503 -----MQTVQQEQLLQ-ETQALQQSFLSEK-------DSLLQRERFIEQEKAKLEQLFQD 2549
Query: 709 E--KQHRIR---QLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKK 763
E K ++R Q + E E R AR + AE R+K+ L++LEQ R++
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 764 AEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
E ++ + RE++ L ++ A E+ + V A K
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Score = 30.4 bits (67), Expect = 7.2
Identities = 37/141 (26%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 265 DFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR--SLLNW-RTKLRRYVAK 321
+F +K D+ +L+ PAT R C LGR +L+ LLN + +LR +
Sbjct: 594 EFRAKIERARSDEGQLS--PATRGAYRDC------LGRLDLQYAKLLNSSKARLRSLESL 645
Query: 322 KLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVA 381
A ++ + +E+E D + T +K+E +L E+K +++
Sbjct: 646 HSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMREL-----ELKEKKIK 700
Query: 382 ELKRKKKKLLREQRKQRERVE 402
EL+ +LLRE R VE
Sbjct: 701 ELQNAGDRLLREDHPARPTVE 721
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 55.1 bits (131), Expect = 3e-07
Identities = 114/614 (18%), Positives = 250/614 (40%), Gaps = 73/614 (11%)
Query: 267 LSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQ 326
L K E + ++E Q E+ + +R L R+ELR R ++ ++Q
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEE-----EQLRKLERQELR---------RERQEEEQQQQ 298
Query: 327 AKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV---AEL 383
+ L +E+E E+ +Q +E++EE E+QL + E + Q++ E
Sbjct: 299 RLRREQQLRRKQEEERREQQEER-REQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 384 KRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAA 443
+R++++L REQ ++R +L+ + E + +R Q L Q
Sbjct: 358 ERREQQLRREQEEERREQQLRREQ-----QLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 444 DTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAG---------VRGHQGLRDQKRMR 494
L R+ + E++ + + + + L R + R ++ R
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 495 LTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLL 554
+++ D+EEE E L + EE+ QE + + E+ ++ L+ + +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ-----EERREQRLKRQEEEER 527
Query: 555 FENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDG 614
+ R + QQ +++Q + LK E L Q+ + + L+ EE+
Sbjct: 528 LQQRLRSEQQLRREQ-EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE-- 584
Query: 615 ISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHR---ILDPEGLALG 671
E+EE E ++ + ++ + + E+P + R +L E
Sbjct: 585 --RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE----E 638
Query: 672 AVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKR- 730
++ +R+ + R E+E L + +E ++ R R+ + ++E E R+R
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER-REQELAEEEQEQARERI 697
Query: 731 ------WR-----EINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDIS----E 775
W+ E +AR K + + ++ +R + E+ R++ E+ + + +
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757
Query: 776 REKVAQLRSL------YKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMK 829
+++ Q R +K+ G+++ + ++ R++R + + + +
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR-ERQLRAEERQQREQRFLPEEEE 816
Query: 830 KDQRAQQRKEQKKK 843
K+QR +QR+E++K+
Sbjct: 817 KEQRRRQRREREKE 830
Score = 54.3 bits (129), Expect = 5e-07
Identities = 121/587 (20%), Positives = 237/587 (40%), Gaps = 84/587 (14%)
Query: 284 PATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKL---KEQAKALDISLSSGEED 340
PA E +R ++ ++L +E R K RR ++ +EQ + + L E +
Sbjct: 893 PALQEQLR---KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 341 EGDEEDSTAGTTKQPSKEEEEE----EEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRK 396
+ ++ K +++EE EE E+ + E K +E EL++++++LLRE+R+
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 397 QRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIY 456
+R R E + R ++ +E+ Q + L R++
Sbjct: 1010 KRRRQEWE----------------------RQYRKKDELQQEE--------EQLLREERE 1039
Query: 457 VSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEE--EEENPLLVP 514
+++ + +L EE + G + R+ +R + E Q KEEE +EE LL
Sbjct: 1040 KRRLQERERQYREEEELQQEE-EQLLGEE--RETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 515 LEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQ------QKQ 568
EK QE + +E L+ + QLL E R K R+Q+ +++
Sbjct: 1097 EPEKRRRQERERQC------------REEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 569 QLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEE 628
++ Q L+ E E + E L+ EE+ + + E E
Sbjct: 1145 EVQQEEEQLLREE-------PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 629 SW---EPLRGKKRSRGPKSDDDGFEIVPIEDPAK-HRILDPEGLALGAVIASSKKAKRDL 684
+ E L+ +KR + + +D ++ +P K + + D + G ++ +
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 685 IDNSFNRYTFNEDEGELPEWFVQEEK---QHRIRQLPVGKKEVEHYRKRWREINARPIKK 741
+ + ++ GE E ++E+ Q R R P +E + R+ +E R K
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP---EEEQLEREEQKEAKRRDRKS 1314
Query: 742 VAEAK-ARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTY 800
E + R++R +R ++T +K + ERE+ R + +E RH
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQL--LQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 801 VVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
+++RR R K + +++ +R QQ ++ + + R+
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLK-EEQQLRCQEREQQLRQDRDRKFRE 1418
Score = 49.7 bits (117), Expect = 1e-05
Identities = 121/617 (19%), Positives = 249/617 (40%), Gaps = 96/617 (15%)
Query: 269 KASEIMVDDEELAQHPATT---EDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKE 325
K E+ ++E+L + ++ C++ L ++E + L R K RR ++L+
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELER 1138
Query: 326 QAKALDISLSSGEE--DEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAEL 383
Q + + E+ E E+ +Q +EEE ++EEEQL + E + QE
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 384 KRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAA 443
R++++L R++RKQR R DE + R + + + +
Sbjct: 1199 YREEEELQRQKRKQRYR-------------DEDQ---------RSDLKWQWEPEKENAVR 1236
Query: 444 DTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKE 503
D + R++ +E D+ L ++L + G Q RD+++ R Q D+
Sbjct: 1237 DNKVYCKGRENEQFRQLE----DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 504 EEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQ 563
EEE + +EEQ E + + QLL E R + R+
Sbjct: 1293 FPEEEQ----------LEREEQK------------EAKRRDRKSQEEKQLLREEREEKRR 1330
Query: 564 QQQKQQLPQTPPSCLKTEIMSPLYQDEAP---KGTEASSGTEAATGLEGEEKDGISDSDS 620
+Q+ + + L+ PL + E + E + LE E++ + +
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 621 STSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKA 680
EE++ LR ++R + + D D + E + D + + ++
Sbjct: 1391 KFLKEEQQ----LRCQEREQQLRQDRDR-KFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 681 KRDLIDNSFNRY----TFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINA 736
++ L + R F E+E L E +E++ HR + +E + R++ R+
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQE--REEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 737 R--------PIKKVAEA-----KARKKRRMLKRLEQTRKKAEAVVNTVDISER-EKVAQL 782
R P +K E + +++R+ L+ +Q R++ D + + QL
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 783 RSLYKKAGLGKEKRHVTYVVAKKGVGR------------KVRRPAGVRGHFKVVDSRMKK 830
R ++ L +++R + + ++ V R ++RR G + + D + ++
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 831 DQRAQQRKEQKKKHKRK 847
D++ Q +E+++ H+++
Sbjct: 1624 DEQLLQEREEQQLHRQE 1640
Score = 49.3 bits (116), Expect = 2e-05
Identities = 121/618 (19%), Positives = 248/618 (40%), Gaps = 80/618 (12%)
Query: 247 TLYHRTSVTDFLRAANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELR 306
TLY + ++ + LR + + E+ ++ E + R + L ++E +
Sbjct: 888 TLYAKPALQEQLRKEQQL-LQEEEEELQREEREKRRRQEQERQYR----EEEQLQQEEEQ 942
Query: 307 SLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEE--- 363
L R K RR + +E+ D L EE EE ++ K EEEE
Sbjct: 943 LLREEREKRRR----QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 364 EEEQLNQTLAEMKAQE--------VAELKRKKKKLLREQRKQRERVELKMDL-PGVSIAD 414
EEEQL + E + ++ EL++++++LLRE+R++R E + +
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 415 EGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLD 474
E E + R Q LE + + L R++ ++ + +L
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQE-EEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 475 PEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGS 534
EE Q LR+++ R + + + EEEE V EE+ +L+EE +
Sbjct: 1118 QEE------EQLLREEREKRRRQELERQYREEEE----VQQEEEQLLREEPEK---RRRQ 1164
Query: 535 FAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKG 594
+ +E L+ + QLL E + K RQ++++Q + L+ + Y+DE +
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE---LQRQKRKQRYRDEDQR- 1220
Query: 595 TEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKK-RSRGPKSDDDGFEIVP 653
++ E E+++ + D+ E E + L + R R + D
Sbjct: 1221 ------SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD-------- 1266
Query: 654 IEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHR 713
L ++ ++ R+ + + + E E E Q+E + R
Sbjct: 1267 ----------------LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 714 IRQLPVGKK--EVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTV 771
R+ K+ E KR R+ R ++ + ++ + L+R E+ RK E +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 772 DISER--EKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMK 829
+ + E+ +LR ++ KE++ + ++ + + R F+ + ++
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR------KFREEEQQLS 1424
Query: 830 KDQRAQQRKEQKKKHKRK 847
+ +R ++ +E++++ +R+
Sbjct: 1425 RQERDRKFREEEQQVRRQ 1442
Score = 44.7 bits (104), Expect = 4e-04
Identities = 98/523 (18%), Positives = 199/523 (38%), Gaps = 71/523 (13%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEE-- 359
R+ S L W+ + R + ++ +EQ + + E+ E + +A + +E
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 360 --EEEEEEEQLNQTLAEMKAQEVAELKRKKKKLL----REQRKQRERVE-LKMDLPGVSI 412
EE ++ EQ E K Q + + ++K+L EQ ++RER + L+ + G+
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 413 ADEGETGMFSLSTIRGHQLLEEVTQG---DMSAADTFLSDLPRDDIYVSDVEDDGDDTSL 469
E + LEE + + A L ++ + + E++
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 470 DSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLW 529
+ E+ R + L+ ++ L E ++ + +E E ++K + Q+E+ L
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR---KDKKLQQKEEQLLG 975
Query: 530 FSKGSFAGIEDDA----DEALEISQAQLLFENRRKGRQQQ------QKQQLPQTPPSCLK 579
E + +E L+ + QLL E R K R+Q+ +K +L Q L+
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 580 TEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRS 639
E Q+ + E + L GEE++ + +EE +
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE----- 1090
Query: 640 RGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEG 699
E + E+P K R + E ++ + + E+
Sbjct: 1091 ----------EQLLREEPEKRRRQERE-----------RQCREE------------EELQ 1117
Query: 700 ELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQ 759
+ E ++EE++ R RQ E+E + E+ + + E +++R+ L+R +
Sbjct: 1118 QEEEQLLREEREKRRRQ------ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 760 TRKKAEAVVNTVDISEREKVAQ--LRSLYKKAGLGKEKRHVTY 800
++ + + E+EK Q R ++ L ++KR Y
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Score = 43.9 bits (102), Expect = 6e-04
Identities = 94/575 (16%), Positives = 225/575 (39%), Gaps = 57/575 (9%)
Query: 306 RSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQ------PSKEE 359
R LL R K R +K +++ + D EE E + ++ ++ P ++
Sbjct: 213 RELLELRRKGRE---EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 360 EEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETG 419
E +EEEEQL + + +E E ++++++L REQ+ +R++ E + + E +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ--EERREQQER 327
Query: 420 MFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELA 479
R QL E + + R+ + E++ + L +
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 480 GVRGHQGLRDQKRMRLTEV--------------------QDDKEEEEEENPLLVPLEEKA 519
+R Q LR ++++R + ++ +EE E+ E++
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 520 VLQEEQANLWFSKGSFAGIEDDADEALEISQAQ---------LLFENRRKGRQQQQKQQL 570
++E+ W + + ++ + Q L E R+ +Q++++QQL
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 571 PQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESW 630
+ + L + E + + +E E EE+ + EEE+
Sbjct: 508 RREQEERREQR----LKRQEEEERLQQRLRSEQQLRREQEER-----REQLLKREEEKRL 558
Query: 631 EPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFN 690
E R ++R + + + + E+ + R+ + L + + + + +
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 691 RYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKK 750
R E E E + ++ E+Q RQ + +++ E +R +K+ E + ++
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR--------LKREEEEERLEQ 670
Query: 751 RRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRK 810
R + E+ R++ A ER K + ++ ++ Y +K G++
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 811 VRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHK 845
R+ + + + + ++++RA ++++++++ +
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Score = 42.7 bits (99), Expect = 0.001
Identities = 104/539 (19%), Positives = 221/539 (41%), Gaps = 61/539 (11%)
Query: 338 EEDEGDEEDSTAGTTKQPSKEEEEEEE---EEQLNQTLAEMKAQEVAELKRKKKKLLREQ 394
EE+ EE+ G ++ + +E E + EE+L Q +E L+ + +K R++
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ-------EEEQLLREEPEKRRRQE 1105
Query: 395 RKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDD 454
R+++ R E ++ + E R ++ EEV Q + L R++
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE--------EQLLREE 1157
Query: 455 IYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRL----TEVQDDK-----EEE 505
++ + +L EE +R Q R Q+R R E+Q K +E
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 506 EEENPL---LVPLEEKAVLQEEQANLWFSKGSFAGIEDD--ADEALEISQAQLLFENRRK 560
++ + L P +E AV + F +ED D + LL E + +
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 561 GRQQQQK--QQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDS 618
R+Q+++ QQ + P + E + Q EA + S + E EEK ++
Sbjct: 1278 DREQERRRWQQRDRHFP---EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 619 DSSTSSEE----EESWEPLRGKKRSRGPKSD-----DDGFEIVPIEDPAKHRILDPEGLA 669
D EE E +PLR ++R R + + + G + + E + + + + L
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 670 LGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRK 729
+ ++ ++ D F E+E +L ++E+ + R+ + E RK
Sbjct: 1395 EEQQLRCQEREQQLRQDRD---RKFREEEQQLS----RQERDRKFREEEQQVRRQERERK 1447
Query: 730 RWREINARPIKKVAEAKARKKRRML-KRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKK 788
E + +++ K R++ ++L +R EQ + E ++ ++ + + +++
Sbjct: 1448 FLEE--EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 789 AGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
L ++ ++ ++ + R+ R + F + ++++ +R QQR++ + + R+
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQR-----QRKFLQEEQQLRRQERGQQRRQDRDRKFRE 1559
Score = 42.4 bits (98), Expect = 0.002
Identities = 109/560 (19%), Positives = 207/560 (36%), Gaps = 115/560 (20%)
Query: 314 KLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA 373
+LR+ +K +E+ + LS E D E+ ++ +E + EEE+QL Q
Sbjct: 1407 QLRQDRDRKFREEEQ----QLSRQERDRKFREEEQQ--VRRQERERKFLEEEQQLRQERH 1460
Query: 374 EMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQ--- 430
+E L+ ++++ L Q + R+ +E + L + F +R +
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL-----RRQERDRKFREQELRSQEPER 1515
Query: 431 -LLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRD 489
LEE Q L R ++ + + L +E RG Q +D
Sbjct: 1516 KFLEEEQQ---------LHRQQRQRKFLQE----------EQQLRRQE----RGQQRRQD 1552
Query: 490 QKRMRLTEVQDDKEEEEE-----ENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADE 544
+ R E Q +E EE+ E LEE+ V ++EQ + +ED+
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF--------MEDEQQL 1604
Query: 545 ALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAA 604
+ Q QL E RK R+ +Q Q + L + + +E P+
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQ--EREEQQLHRQERDRKFLEEEPQ----------- 1651
Query: 605 TGLEGEEKDGISDSDSSTSSEEEESW------EPLRGKKRSRGPKSDDDGFEIVPIEDPA 658
L +E++ D EEE + LR ++R R + ++
Sbjct: 1652 --LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR----RQER 1705
Query: 659 KHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLP 718
+ + L E ++ +R ++ F E QE +Q ++R+
Sbjct: 1706 ERKFLQEE-----------QQLRRQELERKFRE----------EEQLRQETEQEQLRRQ- 1743
Query: 719 VGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISERE- 777
E YRK E RP ++ + + +++ R + EQ R++ E S+R+
Sbjct: 1744 ------ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 778 ----------KVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSR 827
+ QLR + E+ + ++ + ++ R F +
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 828 MKKDQRAQQRKEQKKKHKRK 847
+++Q Q +EQK++ +R+
Sbjct: 1858 RREEQELWQEEEQKRRQERE 1877
Score = 40.4 bits (93), Expect = 0.007
Identities = 102/589 (17%), Positives = 239/589 (40%), Gaps = 40/589 (6%)
Query: 283 HPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYV------AKKLKEQAKALDISLSS 336
H T D+ + D+ GR + L + K+ + A L E+ +A S
Sbjct: 49 HDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKES 108
Query: 337 GEEDEGDEEDSTAGTTKQPSKEEE--------EEEEEEQLNQTLAEMKAQEVAELK---R 385
+D EED + EEE +E+E +L + + + QE E + R
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 386 KKKKLLREQRKQRERVELKMDLPGVSIADEGETGMF-SLSTIRGHQLLEEVTQGDMSAAD 444
+ ++L R++++ +ER E + + + ET F +R +LLE +G
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 445 TFLSDLPRDDIYVSDVEDD--GDDTSL---DSDLDPEELAGVRGHQGLRDQ-KRMRLTEV 498
+D ++ + E + +T L + L EE R Q +Q +++ E+
Sbjct: 229 QRRE--RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 499 QDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENR 558
+ +++EEE++ L ++ QEE+ + ++ ++ E + QL E
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERR--EQQEERREQQERREQQEERREQQLRREQE 344
Query: 559 RKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDS 618
+ QQ +++Q + L+ E + + + + + + + +
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 619 DSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSK 678
++ + LR +++ R + ++ + E + + L E + +
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQRLKREQEERRDWLKREE 462
Query: 679 KAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARP 738
+ +R + + +++E W EE++ R +Q ++ + R+ E +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ----ERREQQLRREQEERREQR 518
Query: 739 IKKVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHV 798
+K+ E + ++R L+ +Q R++ E + +RE+ +L ++ L +E+
Sbjct: 519 LKRQEEEERLQQR--LRSEQQLRREQEE--RREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 799 TYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
+ K+ R+ +R R + ++ R+K+++ + +E++++ + K
Sbjct: 575 RDQLLKREEERRQQRLK--REQEERLEQRLKREEVERLEQEERREQRLK 621
Score = 37.7 bits (86), Expect = 0.045
Identities = 109/591 (18%), Positives = 231/591 (39%), Gaps = 99/591 (16%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKA------LDISLSSGEEDEGDEEDSTAGTTKQP 355
++E R L + R+ ++ K+Q K + L EE+ ++++ ++
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 356 SKEEEEE-----EEEEQLNQTL-------AEMKAQEVAELKRKKKKLL----REQRKQRE 399
+E E+ EEEE+L Q L E + + LKR+++K L REQR +RE
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 400 RVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSD 459
+ E + L + E E L + +L + + + ++ + + + +
Sbjct: 571 QEERRDQL----LKREEERRQQRLKREQEERLEQRLKREEVERLEQ--EERREQRLKREE 624
Query: 460 VEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKA 519
E++ L S+ E R Q R+Q+ R ++ ++EEE E L EE+
Sbjct: 625 PEEERRQQLLKSEEQEER----RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 520 VLQE----------EQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQ 569
QE E+ K + +E +AD ++ ++ RK Q+++Q+
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQ-LESEAD-----ARQSKVYSRPRKQEGQRRRQE 734
Query: 570 LPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEES 629
Q+E + E+ + ++++ D + + EE
Sbjct: 735 ------------------QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 630 WEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSF 689
E R + +R P + ++ E + + PE K+ +R
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE--------EEEKEQRRRQRRERE 828
Query: 690 NRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKK----VAEA 745
F E+E +L +++ R +QL + ++ ++R R R +K + E
Sbjct: 829 KELQFLEEEEQL-------QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 746 KARKK---------RRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKR 796
+ R++ + L++ +Q ++ E + + +R + Q R ++ L +E+
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 797 HVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
+ + K RR R + K + K++Q + E++++ +R+
Sbjct: 942 QLL-----REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Score = 37.4 bits (85), Expect = 0.059
Identities = 61/306 (19%), Positives = 116/306 (37%), Gaps = 25/306 (8%)
Query: 269 KASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAK 328
+ E + + E Q D + ++ +V +++ R + +LRR ++ Q +
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 329 ALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEE------EEEEQLNQTLAEMKAQEVAE 382
D E+ + E+ ++ K EEE E E+QL +E
Sbjct: 1618 --DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Query: 383 LKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSA 442
L+ +++ LR Q + R+ E + L + + +R +L + + +
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRR---QERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 443 ADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDK 502
+T L R + Y +E+ E+L R Q LR Q+R R ++
Sbjct: 1733 QETEQEQLRRQERYRKILEE-------------EQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 503 EEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGR 562
+E EE L ++ +EEQ + + D E Q Q L E ++ R
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ-LEEQEQRLR 1838
Query: 563 QQQQKQ 568
Q++ +Q
Sbjct: 1839 QERDRQ 1844
Score = 32.0 bits (71), Expect = 2.5
Identities = 89/448 (19%), Positives = 171/448 (38%), Gaps = 63/448 (14%)
Query: 363 EEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQ----RERVELKMDLPGVSIADEGET 418
+EE+QL + + ++ + K ++++ LR++R++ R+ + K L + + +
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 419 GMF-----SLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDL 473
F L G Q L + + L + R++ + E D + L
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE--REEQQLHRQERDRKFLEEEPQL 1652
Query: 474 DPEELAGVRGH----------QGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQE 523
+E H Q L++ + +L + D++ EEE L E+ LQE
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 524 EQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQL--PQTPPSCLKTE 581
EQ L + + F + RQ+ +++QL + L+ E
Sbjct: 1713 EQ-------------------QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 582 IMSPLYQDEAPKGTEASSGTEAATGLEGE-EKDGISDSDSSTSSEEEESWEPLRGKKRSR 640
+ P +++ + E L E E+ + +S EEE R +++ R
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813
Query: 641 GPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGE 700
P + K+R + E L L + +RD + ++ E
Sbjct: 1814 ------------PQQRDGKYR-WEEEQLQLEEQ-EQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 701 LPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQ- 759
+ QEE+Q R RQ K EH R++ +E ++V E K+++ + + LE
Sbjct: 1860 EEQELWQEEEQKR-RQERERKLREEHIRRQQKEEQRH--RQVGEIKSQEGKGHGRLLEPG 1916
Query: 760 TRKKAEAVVNTVDISEREKVAQLRSLYK 787
T + A V + + E + + RS Y+
Sbjct: 1917 THQFASVPVRSSPL--YEYIQEQRSQYR 1942
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 4/138 (2%)
Query: 295 QDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQ 354
+ +++ +E + L K + AKK KE+ K L E E E+D KQ
Sbjct: 346 KQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEK----ELKEKERREKREKDEKEKAEKQ 401
Query: 355 PSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIAD 414
KEE +E +E L L E + +E + R+++K ++ ++ + R K P
Sbjct: 402 RLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTL 461
Query: 415 EGETGMFSLSTIRGHQLL 432
G G F+ I+ H +L
Sbjct: 462 AGSCGKFAPFEIKEHMVL 479
Score = 32.0 bits (71), Expect = 2.5
Identities = 28/106 (26%), Positives = 53/106 (50%), Gaps = 13/106 (12%)
Query: 313 TKLRRYVAKKLKEQAKALDISLSSGEEDEG---------DEEDSTAGTTKQPSKE--EEE 361
T LRR K +K + + L +E G +E++ K+ +E +++
Sbjct: 316 TPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKK 375
Query: 362 EEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQR-ERVELKMD 406
EEE+E + E + ++ E K +K++L E+RK+R E +E K++
Sbjct: 376 EEEKELKEKERREKREKDEKE-KAEKQRLKEERRKERQEALEAKLE 420
Score = 30.4 bits (67), Expect = 7.2
Identities = 22/115 (19%), Positives = 50/115 (43%)
Query: 707 QEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAEA 766
+EEK+ + K+E + ++ +E+ + ++ E ++K + E+ RK+ +
Sbjct: 354 REEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQE 413
Query: 767 VVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRGHF 821
+ +R+K + R ++ + EK +T K + + AG G F
Sbjct: 414 ALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKF 468
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 48.9 bits (115), Expect = 2e-05
Identities = 69/341 (20%), Positives = 139/341 (40%), Gaps = 28/341 (8%)
Query: 311 WRTKLRRYVAKKLKEQAKAL-DISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLN 369
W + KK++EQ K D EE+ E + ++ +E+EE+ ++++ N
Sbjct: 420 WEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 370 QTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGH 429
E K + L +K+KL +++ Q + E K+ I D+ E R
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ--EEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 430 QLLEEVTQGDMSAADTFLSDLPR------DDIYVSDVEDDGDDTSLDSDLDPEELAGVRG 483
++ E+ Q M + + D + + + E + + + EE R
Sbjct: 538 KMREQEDQ--MWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 484 HQGLRDQKRMRLTE--VQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDD 541
+ +++ MR E +Q+ +E+ +E+ + EEK +QE++ +W + E+
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEK--MQEQEEKMWEQEEKMWEQEEK 653
Query: 542 ADEALEI-SQAQLLFENRRKGRQQ----------QQKQQLPQTPPSCLKTEIMSPLYQDE 590
E + Q + L+E+ + Q+ +Q++ +T KT + ++E
Sbjct: 654 MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEE 713
Query: 591 APKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWE 631
+ + E E E EEK + + + +EEE WE
Sbjct: 714 SMREREKKMREEEEMMREQEEK--MQEQEEKMQEQEEEMWE 752
Score = 39.3 bits (90), Expect = 0.016
Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 311 WRTKLR-RYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEE------- 362
WR + R R K+L+EQ K L E++E +E ++ E+EE
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376
Query: 363 ---EEEEQLNQTLAEMKAQEVA-----ELKRKKKKLLREQRKQRERVE 402
E+E+Q+ + +M+ QE E R+K++ +REQ K E+VE
Sbjct: 377 RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Score = 38.5 bits (88), Expect = 0.026
Identities = 67/355 (18%), Positives = 133/355 (37%), Gaps = 40/355 (11%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEE 361
RK+ + +LR K +++ K E+++ E ++ +E+EE
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEE 348
Query: 362 EEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMF 421
+ +E++ E K +E E ++++ L EQ KQ E KM + ++ E
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 408
Query: 422 SLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGV 481
+R + + E + R++ + + E D + + EE
Sbjct: 409 KEERMREQEKMWEQV------------EKMREEKKMQEQEKKTRDQ--EEKMQEEERIRE 454
Query: 482 RGHQGLRDQKRMRLTEVQDDK-------EEEEEENPLLVP-----LEEKAVLQEEQANLW 529
R + +++ MR E + K +EE+E +P L E+ +QE++ +W
Sbjct: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 514
Query: 530 FSKGSFAGIEDDADEALEI-------SQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEI 582
+ E+ + ++ Q ++E K R Q+QK Q KT+
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK-MWDQEERMEKKTQE 573
Query: 583 MSPLYQDEAPKGTEASSGTEAATGLEGEE------KDGISDSDSSTSSEEEESWE 631
D+ K E E + EE ++ + + + +EE+ WE
Sbjct: 574 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE 628
Score = 38.1 bits (87), Expect = 0.035
Identities = 62/291 (21%), Positives = 121/291 (41%), Gaps = 36/291 (12%)
Query: 487 LRDQKRMRLTEVQDDKEEEE--EENPLLVPLEEKAVLQEEQANLWFSKGSFAGIED---D 541
LR+QK +R E Q ++EE+ E+ + EEK QEE+ LW + E D
Sbjct: 337 LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER--LWEQEKQMREQEQKMRD 394
Query: 542 ADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGT 601
+E + Q + L E + R+Q++ + + K + +D+ K E
Sbjct: 395 QEERM-WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 602 EAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGK-KRSRGPKSDDDGFEIVPIED---- 656
E + EE++ + + + +EE WE + ++ R P+ + +E +++
Sbjct: 454 EREKKMR-EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512
Query: 657 --PAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQHRI 714
+ +I D E + ++ R+ D + + D+ + + + QEE+
Sbjct: 513 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ--KMWDQEERME-- 568
Query: 715 RQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQTRKKAE 765
KK E +K W + E K R++ RM +R ++ R++ E
Sbjct: 569 ------KKTQEQEKKTWDQ----------EEKMREEERMREREKKMREEEE 603
Score = 35.8 bits (81), Expect = 0.17
Identities = 104/518 (20%), Positives = 210/518 (40%), Gaps = 70/518 (13%)
Query: 321 KKLKEQAKAL--DISLSSGEEDEGDEEDSTAGTTKQPSKEEEEE-EEEEQLNQTLAEMKA 377
K+ E+AK L + ++ +E+ +E+ K+ K+EE+ +EE+L + +M+
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 378 QEVAELKRKKK-----KLLREQRKQ-RERVELKMDLPGVSIADEGETGMFSLSTIRGHQ- 430
QE +++K+ K LREQ K+ RE+ EL+ + E E M+ Q
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQM---QEQEEKMWEQEEKMREQE 368
Query: 431 ---------LLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGV 481
L E+ Q M + + D + + ++ + + E++ +
Sbjct: 369 EKMWRQEERLWEQEKQ--MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 482 RGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDD 541
R + +++Q++ T Q++K +EEE + EK + +EE+ +
Sbjct: 427 REEKKMQEQEKK--TRDQEEKMQEEER----IREREKKMREEEET------------MRE 468
Query: 542 ADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSP-----LYQDEAPKGTE 596
+E ++ Q + ++E K + Q+Q+LP+ + E M Q+E + E
Sbjct: 469 QEEKMQ-KQEENMWEQEEK---EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524
Query: 597 ASSGTEAATGLE---GEEKDGISDSDSSTSSEEEESW--EPLRGKKRSRGPKSDDDGFEI 651
G E + E++D + + + +E++ W E KK K D E
Sbjct: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Query: 652 VPIEDPAKHRIL----DPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEW--- 704
+ E+ + R + E + ++ K + E E W
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 705 ---FVQEEKQHRIRQLPVGKKEV-EHYRKRWREINARPIKKVAEAKARKKR---RMLKRL 757
+ QEEK ++LP K+++ EH + + +E +K+ E + +K+ + K
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 758 EQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEK 795
+Q + + E + + RE+ +R +K +EK
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/83 (25%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
KK +EQ K + ++++ EE+S K+ +EEE E+E+ Q E ++
Sbjct: 694 KKTQEQEK------KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
Query: 381 AELKRKKKKLLREQRKQRERVEL 403
E+ +++K+ ++ K E+ L
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRL 770
Score = 31.6 bits (70), Expect = 3.2
Identities = 25/123 (20%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 278 EELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSG 337
E+L +H E ++ Q+ ++ ++++ + K + + +K++E+ +
Sbjct: 665 EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK-KTWDQEKMREEESMREREKKMR 723
Query: 338 EEDEG-DEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRK 396
EE+E E++ ++ +E+EEE E++ E K E L +K+KL ++
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783
Query: 397 QRE 399
Q +
Sbjct: 784 QEQ 786
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 11/144 (7%)
Query: 700 ELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKRLEQ 759
E+ E ++EE R+ +L V K+ E KR EI +++V EAK ++++L+ LE+
Sbjct: 120 EIEEKLIEEETARRVEEL-VAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELER 178
Query: 760 TRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKKGVGRKVRRPAGVRG 819
R+ A + ER K +L + L + R + AK + V
Sbjct: 179 QRQAELAAQKAREEEERAKREELERI-----LEENNRKIAEAQAKLA----EEQLRIVEE 229
Query: 820 HFKVVDSRMKKDQ-RAQQRKEQKK 842
K+ + RMK +Q R +Q+KE++K
Sbjct: 230 QRKIHEERMKLEQERQRQQKEEQK 253
Score = 36.2 bits (82), Expect = 0.13
Identities = 26/99 (26%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 312 RTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQT 371
+ ++ R V ++++E + ++ L E E A Q ++EEEE + E+L +
Sbjct: 150 KDEIEREVLRRVEEAKRIMEKQLL-----EELERQRQAELAAQKAREEEERAKREELERI 204
Query: 372 LAEMK---AQEVAELKRKKKKLLREQRK-QRERVELKMD 406
L E A+ A+L ++ +++ EQRK ER++L+ +
Sbjct: 205 LEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQE 243
Score = 30.4 bits (67), Expect = 7.2
Identities = 33/157 (21%), Positives = 75/157 (47%), Gaps = 6/157 (3%)
Query: 357 KEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEG 416
K++ EEEE++ + +++ QE+ E +++ R + +RVE +++ I E
Sbjct: 98 KQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREV 157
Query: 417 ETGMFSLSTIRGHQLLEEV---TQGDMSAADTFLSD--LPRDDIYVSDVEDDGDDTSLDS 471
+ I QLLEE+ Q +++A + R+++ E++ +
Sbjct: 158 LRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQA 217
Query: 472 DLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEE 508
L E+L V + + ++ RM+L + + +++EE++
Sbjct: 218 KLAEEQLRIVEEQRKIHEE-RMKLEQERQRQQKEEQK 253
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 48.1 bits (113), Expect = 3e-05
Identities = 86/459 (18%), Positives = 183/459 (39%), Gaps = 51/459 (11%)
Query: 203 PDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAAN 262
P + SK PK +++VQ K V E++ + K + E ++ + + L A
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDE-----------KSEMEEALTAIT 477
Query: 263 PVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKK 322
+S E EE + P E+ + E++ + + ++
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 323 LKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAE 382
+++ D + G E EG E + ++ E E EE E + E K++EVA
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA- 596
Query: 383 LKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSA 442
K++L+ + + ++ + K +P + ++G++ + +EE +G
Sbjct: 597 ---TKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPV-------PKSPVEE--KGKSPV 643
Query: 443 ADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDK 502
+ + + + + S VE+ G S + EE A + ++ + + + ++
Sbjct: 644 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV--EEKAKSPVPKSPVEEAKSKAEVGKGEQ 701
Query: 503 EEEEEENPLLVPLEEKAVLQEEQ-ANLWFSKGSFAGIEDDA-DEALEISQA---QLLFEN 557
+EEEE+ P EEK +EE+ ++ K + + ++++A E + I+++ L E
Sbjct: 702 KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET 761
Query: 558 RRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISD 617
+ +G+ QQ++ + E G S + G +G K+ I+
Sbjct: 762 KEEGKPLQQEK-------------------EKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 802
Query: 618 SDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIED 656
+ EE E +G R +G ++ P ++
Sbjct: 803 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADE 841
Score = 44.7 bits (104), Expect = 4e-04
Identities = 123/591 (20%), Positives = 225/591 (38%), Gaps = 90/591 (15%)
Query: 303 KELRSLLNWRTKLRRYVAK--------KLKEQAKALDISLSSGEEDEGD----------E 344
KE+RS L + + A+ KL E A+ ++ S +E+ + E
Sbjct: 271 KEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIE 330
Query: 345 EDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMK---AQEVAELKRKKKKLLREQRKQRERV 401
+S GT + S E + + EE+ N L+ + Q EL+ K ++ R R+ ++ +
Sbjct: 331 LESVRGTKE--SLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLL 388
Query: 402 ELKMDLPGVSIAD-----EGETGMFSL--STIRGHQLLEEVTQGDMSAADTFLSDLPRDD 454
+KM L + IA EGE FS +I G S + P+
Sbjct: 389 NVKMALD-IEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLK 447
Query: 455 IYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVP 514
+ VE+ ++T ++ + E A + L + E ++KEEE E V
Sbjct: 448 VQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA 507
Query: 515 LEEKAV------LQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQ 568
++ V ++EE+ +G E++ DE + QA+ +G +++
Sbjct: 508 AKKSPVKATAPEVKEEEGEKEEEEGQEE--EEEEDEGAKSDQAE-------EGGSEKEGS 558
Query: 569 QLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEE 628
E +G + TEA EGEE + + SEE
Sbjct: 559 S--------------------EKEEGEQEEGETEAEA--EGEEAEAKEEKKVEEKSEEVA 596
Query: 629 SWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRI----LDPEGLALGAVIASSKKAKRDL 684
+ E L + P+ P+E+ K + ++ +G + +K K +
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 656
Query: 685 IDNSFNRYTFNEDEGELP--EWFVQEEKQHRIRQLPV--GKKEVEHYRKRWREINARPIK 740
+ E++G+ P + V+E+ + + + PV K + E + +E + +K
Sbjct: 657 PKSPV------EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 741 KV-AEAKARKKRRMLKRLEQTRK-----KAEAVVNTVDISEREKVAQLRSLYKKAGLGKE 794
+ E K KK K + + +K K EAV V I++ KV L K+ G +
Sbjct: 711 EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-HLEKETKEEGKPLQ 769
Query: 795 KRHVTYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHK 845
+ +G + G +G K D + + ++ EQ+ K K
Sbjct: 770 QEKEKEKAGGEGGSEEEGSDKGAKGSRK-EDIAVNGEVEGKEEVEQETKEK 819
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 48.1 bits (113), Expect = 3e-05
Identities = 86/459 (18%), Positives = 183/459 (39%), Gaps = 51/459 (11%)
Query: 203 PDKVDSKFFDPKFAFKEVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAAN 262
P + SK PK +++VQ K V E++ + K + E ++ + + L A
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDE-----------KSEMEEALTAIT 101
Query: 263 PVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKK 322
+S E EE + P E+ + E++ + + ++
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 161
Query: 323 LKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAE 382
+++ D + G E EG E + ++ E E EE E + E K++EVA
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA- 220
Query: 383 LKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSA 442
K++L+ + + ++ + K +P + ++G++ + +EE +G
Sbjct: 221 ---TKEELVADAKVEKPE-KAKSPVPKSPVEEKGKSPV-------PKSPVEE--KGKSPV 267
Query: 443 ADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDK 502
+ + + + + S VE+ G S + EE A + ++ + + + ++
Sbjct: 268 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV--EEKAKSPVPKSPVEEAKSKAEVGKGEQ 325
Query: 503 EEEEEENPLLVPLEEKAVLQEEQ-ANLWFSKGSFAGIEDDA-DEALEISQA---QLLFEN 557
+EEEE+ P EEK +EE+ ++ K + + ++++A E + I+++ L E
Sbjct: 326 KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET 385
Query: 558 RRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISD 617
+ +G+ QQ++ + E G S + G +G K+ I+
Sbjct: 386 KEEGKPLQQEK-------------------EKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 426
Query: 618 SDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIED 656
+ EE E +G R +G ++ P ++
Sbjct: 427 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADE 465
Score = 37.7 bits (86), Expect = 0.045
Identities = 83/405 (20%), Positives = 155/405 (38%), Gaps = 66/405 (16%)
Query: 460 VEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEE-----NPLLVP 514
VED+ + EELA ++++K+ E +++ E EEEE +P+
Sbjct: 86 VEDEKSEMEEALTAITEELA-----VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
Query: 515 LEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTP 574
E ++EE+ +G E++ DE + QA+ +G +++
Sbjct: 141 APE---VKEEEGEKEEEEGQEE--EEEEDEGAKSDQAE-------EGGSEKEGSS----- 183
Query: 575 PSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLR 634
E +G + TEA EGEE + + SEE + E L
Sbjct: 184 ---------------EKEEGEQEEGETEAEA--EGEEAEAKEEKKVEEKSEEVATKEELV 226
Query: 635 GKKRSRGPKSDDDGFEIVPIEDPAKHRI----LDPEGLALGAVIASSKKAKRDLIDNSFN 690
+ P+ P+E+ K + ++ +G + +K K + +
Sbjct: 227 ADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV- 285
Query: 691 RYTFNEDEGELP--EWFVQEEKQHRIRQLPV--GKKEVEHYRKRWREINARPIKKV-AEA 745
E++G+ P + V+E+ + + + PV K + E + +E + +K+ E
Sbjct: 286 -----EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE 340
Query: 746 KARKKRRMLKRLEQTRK-----KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTY 800
K KK K + + +K K EAV V I++ KV L K+ G ++
Sbjct: 341 KVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-HLEKETKEEGKPLQQEKEKE 399
Query: 801 VVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHK 845
+G + G +G K D + + ++ EQ+ K K
Sbjct: 400 KAGGEGGSEEEGSDKGAKGSRK-EDIAVNGEVEGKEEVEQETKEK 443
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 48.1 bits (113), Expect = 3e-05
Identities = 106/579 (18%), Positives = 238/579 (41%), Gaps = 73/579 (12%)
Query: 296 DIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQP 355
D+++ + E SL + + + + K++ +AK +++ + EE+E + E TA K
Sbjct: 889 DLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE-LTAKKRKLE 947
Query: 356 SKEEEEEEEEEQLNQTLAEMK-------------AQEVAELKRKKKKLLREQRKQRERVE 402
+ E +++ + L TLA+++ +E+A L KL +E++ +E +
Sbjct: 948 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ 1007
Query: 403 LKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPR------DDIY 456
+D A+E + + + + + Q ++++ +G + DL R D+
Sbjct: 1008 QTLD---DLQAEEDKVNILTKAKTKLEQQVDDL-EGSLEQEKKLRMDLERAKRKLEGDLK 1063
Query: 457 V---SDVEDDGDDTSLDSDLDPEE------LAGVRGHQGLRDQKRMRLTEVQDDKEEEEE 507
+ S ++ + D LD L+ +E ++ + Q + Q + ++ E+Q EE E
Sbjct: 1064 LAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGE 1123
Query: 508 ENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQK 567
E + +A ++++++L I + +EA + AQ+ +R+ Q+ +
Sbjct: 1124 E--IEAERASRAKAEKQRSDL---SRELEEISERLEEAGGATSAQVELNKKREAEFQKLR 1178
Query: 568 QQLPQTPPSCLKTEIMSPLYQDE-----APKGTEASSGTEAATGLEGEEKDGISDSDSST 622
+ L + + L+ E M + + A G + + LE E+ + ++D +
Sbjct: 1179 RDLEE---ATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS 1235
Query: 623 SSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKR 682
S+ E S +G +D E+ E+ + I D A+R
Sbjct: 1236 SNAEAIS--KAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND-------------LTAQR 1280
Query: 683 DLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKV 742
+ Y+ DE + + KQ +Q+ K ++E E A+
Sbjct: 1281 ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE------EETKAKNALAH 1334
Query: 743 AEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVV 802
A +R +L+ + ++ +A + +VAQ R+ Y+ + +R
Sbjct: 1335 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI---QRTEELEE 1391
Query: 803 AKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQK 841
AKK + ++++ H + V+++ ++ +QR + +
Sbjct: 1392 AKKKLAQRLQE---AEEHVEAVNAKCASLEKTKQRLQNE 1427
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/229 (21%), Positives = 102/229 (44%), Gaps = 16/229 (6%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
K LK + ++ S E+D E + G P+KE EE++ E++ ++ +E ++++
Sbjct: 506 KTLKNDCEENGLAKES-EDDLNKESEEEVG----PTKESEEDDSEKESDEDCSEKQSEDG 560
Query: 381 AELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDM 440
+E + ++ L ++ ++ EL ++ + +E ++ ++L+E +G
Sbjct: 561 SEREFEENGLEKDLDEEGSEKELHENVLDKEL-EENDSENSEFEDDGSEKVLDE--EGSE 617
Query: 441 SAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPE---ELAGVRGHQGLRDQKRMRLTE 497
D + ++ V DD D D + E E A + +G D+K L E
Sbjct: 618 REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEK---LFE 674
Query: 498 VQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF--SKGSFAGIEDDADE 544
DDKE+E+ + + +EK ++ F + S + DD+DE
Sbjct: 675 ESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
Score = 32.0 bits (71), Expect = 2.5
Identities = 61/291 (20%), Positives = 113/291 (38%), Gaps = 28/291 (9%)
Query: 358 EEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSI--ADE 415
EE E EE+L A + A E R+ + +R R + P S A E
Sbjct: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
Query: 416 GETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDP 475
TGM I + + G+ F ++ S E + ++ + +
Sbjct: 416 TATGMAFEEPIDEKKFEKTEDGGE------FEEGASENNAKESSPEKEAEEGCPEKE--S 467
Query: 476 EELAGVRGHQGLRDQKR------MRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLW 529
EE RG +G QK +R +E +D ++E ++ L EE + +E + +L
Sbjct: 468 EEGCPKRGFEGSCSQKESEEGNPVRGSE-EDSPKKESKKKTLKNDCEENGLAKESEDDLN 526
Query: 530 FSKGSFAGI-----EDDADEALE--ISQAQLLFENRRKGRQQQQKQQLPQ--TPPSCLKT 580
G EDD+++ + S+ Q + R+ + ++ L + + +
Sbjct: 527 KESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHEN 586
Query: 581 EIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWE 631
+ L ++++ G+E EG E++ D DS EEE+++E
Sbjct: 587 VLDKELEENDSENSEFEDDGSEKVLDEEGSEREF--DEDSDEKEEEEDTYE 635
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/229 (21%), Positives = 102/229 (44%), Gaps = 16/229 (6%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
K LK + ++ S E+D E + G P+KE EE++ E++ ++ +E ++++
Sbjct: 506 KTLKNDCEENGLAKES-EDDLNKESEEEVG----PTKESEEDDSEKESDEDCSEKQSEDG 560
Query: 381 AELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDM 440
+E + ++ L ++ ++ EL ++ + +E ++ ++L+E +G
Sbjct: 561 SEREFEENGLEKDLDEEGSEKELHENVLDKEL-EENDSENSEFEDDGSEKVLDE--EGSE 617
Query: 441 SAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPE---ELAGVRGHQGLRDQKRMRLTE 497
D + ++ V DD D D + E E A + +G D+K L E
Sbjct: 618 REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEK---LFE 674
Query: 498 VQDDKEEEEEENPLLVPLEEKAVLQEEQANLWF--SKGSFAGIEDDADE 544
DDKE+E+ + + +EK ++ F + S + DD+DE
Sbjct: 675 ESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
Score = 32.0 bits (71), Expect = 2.5
Identities = 61/291 (20%), Positives = 113/291 (38%), Gaps = 28/291 (9%)
Query: 358 EEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSI--ADE 415
EE E EE+L A + A E R+ + +R R + P S A E
Sbjct: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
Query: 416 GETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDP 475
TGM I + + G+ F ++ S E + ++ + +
Sbjct: 416 TATGMAFEEPIDEKKFEKTEDGGE------FEEGASENNAKESSPEKEAEEGCPEKE--S 467
Query: 476 EELAGVRGHQGLRDQKR------MRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLW 529
EE RG +G QK +R +E +D ++E ++ L EE + +E + +L
Sbjct: 468 EEGCPKRGFEGSCSQKESEEGNPVRGSE-EDSPKKESKKKTLKNDCEENGLAKESEDDLN 526
Query: 530 FSKGSFAGI-----EDDADEALE--ISQAQLLFENRRKGRQQQQKQQLPQ--TPPSCLKT 580
G EDD+++ + S+ Q + R+ + ++ L + + +
Sbjct: 527 KESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHEN 586
Query: 581 EIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESWE 631
+ L ++++ G+E EG E++ D DS EEE+++E
Sbjct: 587 VLDKELEENDSENSEFEDDGSEKVLDEEGSEREF--DEDSDEKEEEEDTYE 635
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 47.4 bits (111), Expect = 6e-05
Identities = 92/415 (22%), Positives = 170/415 (40%), Gaps = 31/415 (7%)
Query: 301 GRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEE 360
G KEL W+ + +K +EQ + + E +EG EE+ G ++ +EEE
Sbjct: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKE---RNQEMEEGGEEEHGEGEEEEGDREEE 748
Query: 361 EEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGETGM 420
EE+E E E + +EV E +R+K++ +RK+ ER + G D+GE G
Sbjct: 749 EEKEGEGKE----EGEGEEV-EGEREKEE---GERKKEERA--GKEEKGEEEGDQGE-GE 797
Query: 421 FSLSTIRGHQLLE--EVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSDLDPEEL 478
+ RG + E EV G++ + ++ E++G+ + + + EE
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGK---GEREEEEEEGEGEEEEGEGEEEEGEGEEEEG 854
Query: 479 AGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGI 538
G +G + E + + EEEE E E + +EE+ +G G
Sbjct: 855 EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE--GEEEGEGEGEEEEGE---GEGEEEGE 909
Query: 539 EDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAP-KGTEA 597
+ +E E + E +G +++ + + + E ++E +G E
Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
Query: 598 SSGTEAATGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDP 657
G EGEE++G + + EEE E G++ G +++ E +E
Sbjct: 970 GEGEGEEGEGEGEEEEG--EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE---VEGE 1024
Query: 658 AKHRILDPEG-LALGAVIASSKKAKRDLIDNSFNRYTFNEDEGELPEWFVQEEKQ 711
+ + EG G ++ + + +N NR E+EG+ E +E ++
Sbjct: 1025 VEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079
Score = 43.5 bits (101), Expect = 8e-04
Identities = 99/476 (20%), Positives = 178/476 (37%), Gaps = 27/476 (5%)
Query: 338 EEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQ 397
EE E E+D G ++P + E+E E+E E K ++ E ++K+++ ++ +
Sbjct: 672 EEREKGEKDKGRGEMERPGEGEKELAEKE-------EWKKRDGEEQEQKEREQGHQKERN 724
Query: 398 RERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYV 457
+E E + G +EG+ G +E +G+ + + R
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEG----KEEGEGEEVEGEREKEEGERKKEER 780
Query: 458 SDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEE 517
+ E+ G++ + + EE G RG + + + EV++ K E EEE EE
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEG-RGEE-KEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838
Query: 518 KAVLQEEQA----NLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQT 573
+ +EE+ KG G E + +E E + + E +++ + + +
Sbjct: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Query: 574 PPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSSEEEESW--- 630
E ++E +G G E E EE +G + EEE W
Sbjct: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
Query: 631 -EPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSF 689
E G+ G ++G E E+ + + EG G ++ +
Sbjct: 959 EEEGEGEGEEEGEGEGEEG-EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017
Query: 690 NRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEAKARK 749
E EGE E +EE+ + + E E R+ RE K E +
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRN-REEEEEEEGKYQETGEEE 1076
Query: 750 KRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
R + + KK + +V + K Q +S+ G GKE+R V +K+
Sbjct: 1077 NER---QDGEEYKKVSKIKGSVKYG-KHKTYQKKSVTNTQGNGKEQRSKMPVQSKR 1128
Score = 31.6 bits (70), Expect = 3.2
Identities = 64/325 (19%), Positives = 133/325 (40%), Gaps = 45/325 (13%)
Query: 337 GEEDEGD---EEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLRE 393
GEE+EG+ EE+ G ++ +E E E EEE+ E + +E E + ++++ E
Sbjct: 849 GEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE-----GEGEGEEEGEGEGEEEEGEGE 903
Query: 394 QRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRD 453
++ E + + G +EGE G G E+ +G+ + +
Sbjct: 904 GEEEGEGEGEEEEGEGKG-EEEGEEGEGEGEEEEGEGEGED-GEGEGEEEEGEWEGEEEE 961
Query: 454 DIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLV 513
+ E +G+ + + + EE G G + +++ E +++ E E EE
Sbjct: 962 GEGEGEEEGEGEGEEGEGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEE----- 1015
Query: 514 PLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQT 573
EE+ ++ E +G G E++ +E E + + E R+ R+++++++
Sbjct: 1016 --EEEGEVEGEVEG---EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE---- 1066
Query: 574 PPSCLKTEIMSPLYQDEAPKGTEASSGTE--AATGLEGEEKDG-------ISDSDSSTSS 624
YQ+ + E G E + ++G K G S +++ +
Sbjct: 1067 -----------GKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNG 1115
Query: 625 EEEESWEPLRGKKRSRGPKSDDDGF 649
+E+ S P++ K+ + S F
Sbjct: 1116 KEQRSKMPVQSKRLLKNGPSGSKKF 1140
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 47.4 bits (111), Expect = 6e-05
Identities = 67/322 (20%), Positives = 139/322 (43%), Gaps = 28/322 (8%)
Query: 278 EELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSG 337
E L Q E++ C++ +++ L + + L+ + ++L+E K D+ ++
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341
Query: 338 EEDEGDEEDSTAGTTK-QPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKL------ 390
+ D+ + + K E + Q+++TL EMK +E+A+L+ + K++
Sbjct: 342 TKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL-EMKEEEIAQLRSRIKQMTTQGEE 400
Query: 391 LREQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQL--LEEVTQGDMSAADTFLS 448
LREQ+++ ER + +S A + E L Q+ +E+ ++ + + LS
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 449 DLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEE 508
+ ++ + V + L L +ELA +K LT+ +E E +E
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQK-LHEKELA----------RKEQELTKKLQTREREFQE 509
Query: 509 NPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQ 568
+ K L++ Q+ E A E LE+ + +L E+ K R QQ+
Sbjct: 510 -------QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 569 QLPQTPPSCLKTEIMSPLYQDE 590
+ +T L++ + L +++
Sbjct: 563 ETYRTRILELESSLEKSLQENK 584
Score = 33.5 bits (75), Expect = 0.85
Identities = 41/172 (23%), Positives = 78/172 (45%), Gaps = 15/172 (8%)
Query: 245 DLTLYHRTSVTDFLR-AANPVDFLSKASEIMVDDEELAQHPATTEDIRVCCQDIRVLGRK 303
DL + +T + LR A N ++ L + +++ + + H E + + ++I L R
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH----ETLEMKEEEIAQL-RS 389
Query: 304 ELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQ-PSKEEEEE 362
++ + +LR K + + L+ +LS+ ++ E A +Q + E+ E
Sbjct: 390 RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE 449
Query: 363 EEEEQLNQTLAEMKAQEVAELKRK-------KKKLLREQRKQRERVELKMDL 407
EE L Q L+ +K QEV ++ +K K + L E+ R+ EL L
Sbjct: 450 EERISLQQELSRVK-QEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKL 500
Score = 30.0 bits (66), Expect = 9.4
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 37/161 (22%)
Query: 357 KEEEEEEEEEQLNQTLAEMKAQEVAELKRKK--KKLLREQRKQRERVELKMDL---PGVS 411
K+E ++E EE++ Q QE ELK K+L+RE Q + E ++++ ++
Sbjct: 1968 KKEYDQEREEKIKQ------EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Query: 412 IADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDS 471
A E E + +QLL+++ + D DL R ++ D ++
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKKIAEKD--------DDLKRTAKRYEEILDAREE----- 2068
Query: 472 DLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEE--EEEENP 510
E A VR Q +L E+Q ++ E+EENP
Sbjct: 2069 ----EMTAKVRDLQ-------TQLEELQKKYQQKLEQEENP 2098
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 47.4 bits (111), Expect = 6e-05
Identities = 92/416 (22%), Positives = 168/416 (40%), Gaps = 58/416 (13%)
Query: 325 EQAKALDISLSSGEEDEGDE------EDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQ 378
E+ + L++S S EE+E +E E+ ++ +EEEEEEEEE + + +
Sbjct: 1057 ERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKP 1116
Query: 379 EVAELKRKKKKLLREQR-KQRERVELKMDLPGVSIADE----------GETGMFSLSTIR 427
+ +KRK+ +L+++R ++R R+ + +S E E M L
Sbjct: 1117 QSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTC 1176
Query: 428 GHQLLEEVTQGDMSAADTFLSDLPRD---------------DIYVSDVEDDGDDTSLDSD 472
++ E+ + + A R D +++ DD + S
Sbjct: 1177 EIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSK 1236
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEE-----EEENPLLVPLE-EKAVLQEEQA 526
+PE L + Q + L++ + +KE + P P+E ++ V EEQ
Sbjct: 1237 DNPEPL---KCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQK 1293
Query: 527 NLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPP-SCLKTEIMSP 585
K S + I + +E E +A L E R R++ P T P + +++ P
Sbjct: 1294 ETSEGKTSPSPIRIE-EEVKETGEALLPQEENR--REETCAPVSPNTSPGEKPEDDLIKP 1350
Query: 586 LYQDEAPKGTEASSGTEAATGLEGEEKDG----ISDSDSSTSSEEEESWEPLRGKKRSRG 641
++E + E E EGEE++G D D + S E+E EP ++
Sbjct: 1351 EEEEEEEEEEEEEEEEE-----EGEEEEGGGNVEKDPDGAKSQEKE---EPEISTEKEDS 1402
Query: 642 PKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNED 697
+ DD E E+P+ + D + + + S++ K +L SF N++
Sbjct: 1403 ARLDDHEEEEEEDEEPSHNEDHDADD-EDDSHMESAEVEKEELPRESFKEVLENQE 1457
Score = 36.6 bits (83), Expect = 0.10
Identities = 66/339 (19%), Positives = 133/339 (39%), Gaps = 31/339 (9%)
Query: 276 DDEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLS 335
+ +E ++ + IR+ ++++ G L N R + V+ K D +
Sbjct: 1291 EQKETSEGKTSPSPIRIE-EEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIK 1349
Query: 336 SGEEDEGDEEDSTAGTTKQPSKEEEEEEEEE-----QLNQTLAEMKAQEVAELKRKKKKL 390
EE+E +EE+ + +EEEE EEEE + + A+ + +E E+ +K+
Sbjct: 1350 PEEEEEEEEEE-------EEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDS 1402
Query: 391 LR-EQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLS- 448
R + ++ E + + AD+ + + + +L E + + +TFL
Sbjct: 1403 ARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDL 1462
Query: 449 DLPRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRM--RLTEVQDDKEEEE 506
++ + D G D + + +P+ELAG D++ + QD K +E
Sbjct: 1463 NVQPGHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKE 1522
Query: 507 ------EENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRK 560
E NP + ++ + V + S+ +D + E +A +N +
Sbjct: 1523 VDTEFKEGNPATMEIDSETVQAVQSLTQESSEQ-----DDTFQDCAETQEACRSLQNYTR 1577
Query: 561 GRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASS 599
Q Q+ T C +++ SP+ + G S
Sbjct: 1578 A---DQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRS 1613
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEE 361
+ E R LL+ + K ++ + + S EE+E +EE+ G+T + S+EEEE
Sbjct: 244 KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 303
Query: 362 EEEEEQ-----LNQTLAEMKAQEVAE 382
EEEEE+ ++ +E A+EV+E
Sbjct: 304 EEEEEEEETGSNSEEASEQSAEEVSE 329
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 325 EQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK 384
E + A S S EE+E +EE+ T+++ +EEEEEEEEE+ + +E +++ AE
Sbjct: 268 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 327
Query: 385 RKKKKLLREQRKQRERV----ELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGD 439
+++ E+R+ + E + D D GE+ G +T+GD
Sbjct: 328 SEEEMSEDEERENENHLLVVPESRFD------RDSGESEEAEEEVGEGTPQSSALTEGD 380
Score = 36.6 bits (83), Expect = 0.10
Identities = 52/248 (20%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 353 KQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSI 412
K+ + + E+++EQ Q E +A+E + + ++++ R RE
Sbjct: 162 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE-----------DY 210
Query: 413 ADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
+D+ + +S S R + E+ G + + + RD +SD++D D S
Sbjct: 211 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE--RD--LLSDLQDISDSERKTSS 266
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
+ G + E ++++EEEEEE EE+ +EE+
Sbjct: 267 AESSSAESGSGSE-----------EEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---ET 312
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEI-MSPLYQDEA 591
GS +++EA E S ++ E + +++ + L P S + S ++E
Sbjct: 313 GS------NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEV 366
Query: 592 PKGTEASS 599
+GT SS
Sbjct: 367 GEGTPQSS 374
Score = 35.0 bits (79), Expect = 0.29
Identities = 19/69 (27%), Positives = 39/69 (56%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
+K++E+ D+ S E + +S++ + S+EEEEEEEEE+ + +E +E
Sbjct: 243 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 302
Query: 381 AELKRKKKK 389
E + ++++
Sbjct: 303 EEEEEEEEE 311
Score = 31.2 bits (69), Expect = 4.2
Identities = 64/339 (18%), Positives = 135/339 (39%), Gaps = 30/339 (8%)
Query: 489 DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEI 548
++KR R ++++ ++E+ E+ EE+ +E + + + D +A
Sbjct: 160 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 219
Query: 549 SQAQLLFENRR----KGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAA 604
S++ R GR+ +++++ + L +++ + E+SS +
Sbjct: 220 SRSPPRPPRERFELGDGRKPVKEEKMEERD---LLSDLQDISDSERKTSSAESSSAESGS 276
Query: 605 TGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSD---DDGFEIVPIEDPAK-- 659
E EE++ + + STS E EE E ++ G S+ + E V E+ ++
Sbjct: 277 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 336
Query: 660 ------HRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE--GELPEWFVQEEKQ 711
H ++ PE S++A+ ++ + + E + + P E KQ
Sbjct: 337 ERENENHLLVVPES-RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 395
Query: 712 HRIRQLPV--GKKEVEHYR--KRWRE-----INARPIKKVAEAKARKKRRMLKRLEQTRK 762
+ LP G + VE ++ R E + KK E A K+ +M K E
Sbjct: 396 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 455
Query: 763 KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYV 801
+ +NT+ ++ + +R + + + K + YV
Sbjct: 456 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV 494
Score = 30.0 bits (66), Expect = 9.4
Identities = 34/163 (20%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 686 DNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEA 745
++ + R ED GE + + Q R+ V ++ E +++W+ A
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKH---------ARV 114
Query: 746 KARK-KRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAK 804
K R+ +RR R EQ + + E ER+K ++ + + +E+ + + K
Sbjct: 115 KEREHERRKRHREEQDKARREW--------ERQKRREMAREHSR----RERDRLEQLERK 162
Query: 805 KGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
+ RK+R +K+QR Q+ +E++ + +RK
Sbjct: 163 RERERKMRE--------------QQKEQREQKERERRAEERRK 191
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEE 361
+ E R LL+ + K ++ + + S EE+E +EE+ G+T + S+EEEE
Sbjct: 254 KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 313
Query: 362 EEEEEQ-----LNQTLAEMKAQEVAE 382
EEEEE+ ++ +E A+EV+E
Sbjct: 314 EEEEEEEETGSNSEEASEQSAEEVSE 339
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 325 EQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK 384
E + A S S EE+E +EE+ T+++ +EEEEEEEEE+ + +E +++ AE
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 337
Query: 385 RKKKKLLREQRKQRERV----ELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGD 439
+++ E+R+ + E + D D GE+ G +T+GD
Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFD------RDSGESEEAEEEVGEGTPQSSALTEGD 390
Score = 37.7 bits (86), Expect = 0.045
Identities = 80/411 (19%), Positives = 150/411 (36%), Gaps = 69/411 (16%)
Query: 223 QAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLR-AANPVDFLSKASEIMVDDE--- 278
+ KT+ E++ +KK + E + ++ + D R + + EI + +
Sbjct: 9 KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYR 68
Query: 279 -ELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSG 337
E + ED + + + + RKE K+ +K KE+ + S G
Sbjct: 69 REDSMEDRGEEDDSLAIKPPQQMSRKE---------KVHHRKDEKRKEKCRHHSHSAEGG 119
Query: 338 EEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLA------EMKAQEVAELKRKKKKLL 391
+ E + + +++ E E Q + +A E E E KR++++ +
Sbjct: 120 KHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 179
Query: 392 REQRK-QRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDL 450
REQ+K QRE+ E + A+E + + H D A +
Sbjct: 180 REQQKEQREQKERERR------AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 233
Query: 451 PR---------------------DDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRD 489
PR + +SD++D D S + G +
Sbjct: 234 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE---- 289
Query: 490 QKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEIS 549
E ++++EEEEEE EE+ +EE+ GS +++EA E S
Sbjct: 290 -------EEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---ETGS------NSEEASEQS 333
Query: 550 QAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEI-MSPLYQDEAPKGTEASS 599
++ E + +++ + L P S + S ++E +GT SS
Sbjct: 334 AEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSS 384
Score = 31.2 bits (69), Expect = 4.2
Identities = 64/339 (18%), Positives = 135/339 (39%), Gaps = 30/339 (8%)
Query: 489 DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEI 548
++KR R ++++ ++E+ E+ EE+ +E + + + D +A
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 229
Query: 549 SQAQLLFENRR----KGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAA 604
S++ R GR+ +++++ + L +++ + E+SS +
Sbjct: 230 SRSPPRPPRERFELGDGRKPVKEEKMEERD---LLSDLQDISDSERKTSSAESSSAESGS 286
Query: 605 TGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSD---DDGFEIVPIEDPAK-- 659
E EE++ + + STS E EE E ++ G S+ + E V E+ ++
Sbjct: 287 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 346
Query: 660 ------HRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE--GELPEWFVQEEKQ 711
H ++ PE S++A+ ++ + + E + + P E KQ
Sbjct: 347 ERENENHLLVVPES-RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 405
Query: 712 HRIRQLPV--GKKEVEHYR--KRWRE-----INARPIKKVAEAKARKKRRMLKRLEQTRK 762
+ LP G + VE ++ R E + KK E A K+ +M K E
Sbjct: 406 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 465
Query: 763 KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYV 801
+ +NT+ ++ + +R + + + K + YV
Sbjct: 466 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV 504
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEE 361
+ E R LL+ + K ++ + + S EE+E +EE+ G+T + S+EEEE
Sbjct: 245 KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 304
Query: 362 EEEEEQ-----LNQTLAEMKAQEVAE 382
EEEEE+ ++ +E A+EV+E
Sbjct: 305 EEEEEEEETGSNSEEASEQSAEEVSE 330
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 325 EQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK 384
E + A S S EE+E +EE+ T+++ +EEEEEEEEE+ + +E +++ AE
Sbjct: 269 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 328
Query: 385 RKKKKLLREQRKQRERV----ELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGD 439
+++ E+R+ + E + D D GE+ G +T+GD
Sbjct: 329 SEEEMSEDEERENENHLLVVPESRFD------RDSGESEEAEEEVGEGTPQSSALTEGD 381
Score = 36.6 bits (83), Expect = 0.10
Identities = 52/248 (20%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 353 KQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSI 412
K+ + + E+++EQ Q E +A+E + + ++++ R RE
Sbjct: 163 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE-----------DY 211
Query: 413 ADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
+D+ + +S S R + E+ G + + + RD +SD++D D S
Sbjct: 212 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE--RD--LLSDLQDISDSERKTSS 267
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
+ G + E ++++EEEEEE EE+ +EE+
Sbjct: 268 AESSSAESGSGSE-----------EEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---ET 313
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEI-MSPLYQDEA 591
GS +++EA E S ++ E + +++ + L P S + S ++E
Sbjct: 314 GS------NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEV 367
Query: 592 PKGTEASS 599
+GT SS
Sbjct: 368 GEGTPQSS 375
Score = 35.8 bits (81), Expect = 0.17
Identities = 32/150 (21%), Positives = 65/150 (43%), Gaps = 9/150 (6%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
+K++E+ D+ S E + +S++ + S+EEEEEEEEE+ + +E +E
Sbjct: 244 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 303
Query: 381 AELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGET---------GMFSLSTIRGHQL 431
E + ++++ + E+ ++ +S +E E F + +
Sbjct: 304 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 363
Query: 432 LEEVTQGDMSAADTFLSDLPRDDIYVSDVE 461
EEV +G ++ D D +S +E
Sbjct: 364 EEEVGEGTPQSSALTEGDYVPDSPALSPIE 393
Score = 30.4 bits (67), Expect = 7.2
Identities = 64/339 (18%), Positives = 135/339 (39%), Gaps = 30/339 (8%)
Query: 489 DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEI 548
++KR R ++++ ++E+ E+ EE+ +E + + + D +A
Sbjct: 161 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 220
Query: 549 SQAQLLFENRR----KGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAA 604
S++ R GR+ +++++ + L +++ + E+SS +
Sbjct: 221 SRSPPRPPRERFELGDGRKPVKEEKMEERD---LLSDLQDISDSERKTSSAESSSAESGS 277
Query: 605 TGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSD---DDGFEIVPIEDPAK-- 659
E EE++ + + STS E EE E ++ G S+ + E V E+ ++
Sbjct: 278 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 337
Query: 660 ------HRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE--GELPEWFVQEEKQ 711
H ++ PE S++A+ ++ + + E + + P E KQ
Sbjct: 338 ERENENHLLVVPES-RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 396
Query: 712 HRIRQLPV--GKKEVEHYR--KRWRE-----INARPIKKVAEAKARKKRRMLKRLEQTRK 762
+ LP G + VE ++ R E + KK E A K+ +M K E
Sbjct: 397 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 456
Query: 763 KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYV 801
+ +NT+ ++ + +R + + + K + YV
Sbjct: 457 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV 495
Score = 30.0 bits (66), Expect = 9.4
Identities = 33/162 (20%), Positives = 63/162 (38%), Gaps = 33/162 (20%)
Query: 686 DNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIKKVAEA 745
++ + R ED GE + + Q + +KE H+RK E
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQ------MSRKEKVHHRKD-------------EK 104
Query: 746 KARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYVVAKK 805
+ KK +K E+ ++ + D + RE Q R + +E+ + + K+
Sbjct: 105 RKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 164
Query: 806 GVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK 847
RK+R +K+QR Q+ +E++ + +RK
Sbjct: 165 ERERKMR--------------EQQKEQREQKERERRAEERRK 192
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 302 RKELRSLLNWRTKLRRYVAKKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEE 361
+ E R LL+ + K ++ + + S EE+E +EE+ G+T + S+EEEE
Sbjct: 254 KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 313
Query: 362 EEEEEQ-----LNQTLAEMKAQEVAE 382
EEEEE+ ++ +E A+EV+E
Sbjct: 314 EEEEEEEETGSNSEEASEQSAEEVSE 339
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 325 EQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELK 384
E + A S S EE+E +EE+ T+++ +EEEEEEEEE+ + +E +++ AE
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 337
Query: 385 RKKKKLLREQRKQRERV----ELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGD 439
+++ E+R+ + E + D D GE+ G +T+GD
Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFD------RDSGESEEAEEEVGEGTPQSSALTEGD 390
Score = 36.6 bits (83), Expect = 0.10
Identities = 52/248 (20%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 353 KQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQRERVELKMDLPGVSI 412
K+ + + E+++EQ Q E +A+E + + ++++ R RE
Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE-----------DY 220
Query: 413 ADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDLPRDDIYVSDVEDDGDDTSLDSD 472
+D+ + +S S R + E+ G + + + RD +SD++D D S
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE--RD--LLSDLQDISDSERKTSS 276
Query: 473 LDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSK 532
+ G + E ++++EEEEEE EE+ +EE+
Sbjct: 277 AESSSAESGSGSE-----------EEEEEEEEEEEEGSTSEESEEEEEEEEEEEE---ET 322
Query: 533 GSFAGIEDDADEALEISQAQLLFENRRKGRQQQQKQQLPQTPPSCLKTEI-MSPLYQDEA 591
GS +++EA E S ++ E + +++ + L P S + S ++E
Sbjct: 323 GS------NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEV 376
Query: 592 PKGTEASS 599
+GT SS
Sbjct: 377 GEGTPQSS 384
Score = 35.8 bits (81), Expect = 0.17
Identities = 32/150 (21%), Positives = 65/150 (43%), Gaps = 9/150 (6%)
Query: 321 KKLKEQAKALDISLSSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEV 380
+K++E+ D+ S E + +S++ + S+EEEEEEEEE+ + +E +E
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 312
Query: 381 AELKRKKKKLLREQRKQRERVELKMDLPGVSIADEGET---------GMFSLSTIRGHQL 431
E + ++++ + E+ ++ +S +E E F + +
Sbjct: 313 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 372
Query: 432 LEEVTQGDMSAADTFLSDLPRDDIYVSDVE 461
EEV +G ++ D D +S +E
Sbjct: 373 EEEVGEGTPQSSALTEGDYVPDSPALSPIE 402
Score = 30.4 bits (67), Expect = 7.2
Identities = 17/59 (28%), Positives = 31/59 (52%), Gaps = 2/59 (3%)
Query: 339 EDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLREQRKQ 397
ED G+E+DS A K P + +E+ + ++ E K V E +R+ ++ R + +Q
Sbjct: 74 EDRGEEDDSLA--IKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 130
Score = 30.4 bits (67), Expect = 7.2
Identities = 64/339 (18%), Positives = 135/339 (39%), Gaps = 30/339 (8%)
Query: 489 DQKRMRLTEVQDDKEEEEEENPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEI 548
++KR R ++++ ++E+ E+ EE+ +E + + + D +A
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 229
Query: 549 SQAQLLFENRR----KGRQQQQKQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAA 604
S++ R GR+ +++++ + L +++ + E+SS +
Sbjct: 230 SRSPPRPPRERFELGDGRKPVKEEKMEERD---LLSDLQDISDSERKTSSAESSSAESGS 286
Query: 605 TGLEGEEKDGISDSDSSTSSEEEESWEPLRGKKRSRGPKSD---DDGFEIVPIEDPAK-- 659
E EE++ + + STS E EE E ++ G S+ + E V E+ ++
Sbjct: 287 GSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDE 346
Query: 660 ------HRILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEDE--GELPEWFVQEEKQ 711
H ++ PE S++A+ ++ + + E + + P E KQ
Sbjct: 347 ERENENHLLVVPES-RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 405
Query: 712 HRIRQLPV--GKKEVEHYR--KRWRE-----INARPIKKVAEAKARKKRRMLKRLEQTRK 762
+ LP G + VE ++ R E + KK E A K+ +M K E
Sbjct: 406 ELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPI 465
Query: 763 KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHVTYV 801
+ +NT+ ++ + +R + + + K + YV
Sbjct: 466 TSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV 504
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,364,416
Number of Sequences: 37866
Number of extensions: 1601283
Number of successful extensions: 26138
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 696
Number of HSP's that attempted gapping in prelim test: 13893
Number of HSP's gapped (non-prelim): 7616
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.