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Search of human proteins with 194018484
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018484 NLR family, pyrin domain containing 11 [Homo
sapiens]
(1033 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 2077 0.0
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 586 e-167
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 557 e-158
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 515 e-146
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 418 e-116
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 391 e-108
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 382 e-106
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 382 e-106
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 370 e-102
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 366 e-101
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 360 3e-99
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 343 4e-94
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 329 7e-90
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 323 4e-88
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 320 4e-87
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 315 1e-85
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 281 3e-75
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 250 4e-66
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 250 4e-66
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 250 4e-66
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 250 6e-66
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 250 6e-66
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 194 4e-49
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 2077 bits (5381), Expect = 0.0
Identities = 1033/1033 (100%), Positives = 1033/1033 (100%)
Query: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTKEELANVLPISY 60
MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTKEELANVLPISY
Sbjct: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTKEELANVLPISY 60
Query: 61 EGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKF 120
EGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKF
Sbjct: 61 EGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKF 120
Query: 121 FRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMI 180
FRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMI
Sbjct: 121 FRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMI 180
Query: 181 SYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNV 240
SYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNV
Sbjct: 181 SYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNV 240
Query: 241 NESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQL 300
NESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQL
Sbjct: 241 NESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQL 300
Query: 301 SNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQ 360
SNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQ
Sbjct: 301 SNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQ 360
Query: 361 LCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCV 420
LCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCV
Sbjct: 361 LCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCV 420
Query: 421 GFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKE 480
GFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKE
Sbjct: 421 GFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKE 480
Query: 481 KREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT 540
KREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT
Sbjct: 481 KREQYSDFNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT 540
Query: 541 HHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR 600
HHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR
Sbjct: 541 HHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR 600
Query: 601 IFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHS 660
IFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHS
Sbjct: 601 IFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHS 660
Query: 661 SCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQI 720
SCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQI
Sbjct: 661 SCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQI 720
Query: 721 SHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780
SHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL
Sbjct: 721 SHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780
Query: 781 VLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLS 840
VLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLS
Sbjct: 781 VLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLS 840
Query: 841 GCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900
GCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM
Sbjct: 841 GCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900
Query: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT
Sbjct: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
Query: 961 QTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSA 1020
QTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSA
Sbjct: 961 QTQQLLMTVKERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSA 1020
Query: 1021 AMRTSNTASRQPL 1033
AMRTSNTASRQPL
Sbjct: 1021 AMRTSNTASRQPL 1033
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 586 bits (1511), Expect = e-167
Identities = 346/989 (34%), Positives = 538/989 (54%), Gaps = 22/989 (2%)
Query: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLP 57
MA S +DF L+WYLE L +EF+ FK++L + L +L Q P ++ K EELAN+L
Sbjct: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
Query: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFH 117
YE Q WN+ IF M ++DLC K++ R + +A ++KF W S + + H
Sbjct: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
Query: 118 YKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQ 177
F +V + L + + V + G + GKT ++ ++ W ++++
Sbjct: 121 LYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFR 179
Query: 178 NMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFE 237
+ Y + E+ ++ +SLA+LI+++WPD API +I+S P++LLF+++ + ++
Sbjct: 180 DRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGG 239
Query: 238 LNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTT 297
LN +S LC + +K P+ VLL SLL++KM P LI+ +P ++ + +
Sbjct: 240 LNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQP 299
Query: 298 LQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGR 357
+ R +YF FFKD +RA A LV E E L +C++ +LCWI CT LK++M KG+
Sbjct: 300 RGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGK 359
Query: 358 DFQLCCQTPTDLHAHFLADALTSEA--GLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGE 415
D L CQ+ T +++ F+ + T E G T H LK LC LAA G++ T F +
Sbjct: 360 DLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQ--LKALCSLAAEGMWTDTFEFCED 417
Query: 416 DLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAV----PNYLI 471
DLR G +AD+ L ILL + Y F+H+ +QEFC A+ +L+ P+ +
Sbjct: 418 DLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAV 477
Query: 472 PSGSREYKEKREQYSDFNQVFT--FIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYM 529
E+ + +F F+ GLLN ++ L+ FG+QL K +
Sbjct: 478 RCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQ--EIKQQIHQCL 535
Query: 530 KHLDR--DPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDY 587
K L +P+ + +FYCL+E ++ FVK V+ L E ++ + D++VS YCL Y
Sbjct: 536 KSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKY 595
Query: 588 CCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNG 647
C LR L SVQ +F+ ++ +++ SL+ W ICS+ T LREL + D+ L+
Sbjct: 596 CSSLRKLCFSVQNVFKKED---EHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSE 652
Query: 648 ISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
+ L H SC+L+ L ++ VS + L + L L YLS T +S +
Sbjct: 653 STFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIR 712
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
L D L+ P + L+L+ C L +CE +A LL + L L +S N L + G+ +LC
Sbjct: 713 SLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDT-GVPLLC 771
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
+AL P+ L+ L+L FC L+E CC + +LL + ++R LDL N LK+ G+ + L
Sbjct: 772 EALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEAL 831
Query: 828 LFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHP 887
P C L+ L L CF ++ C+ +A + +N+ L+ L+IG N+I D G+QLLC L H
Sbjct: 832 KHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHT 891
Query: 888 NCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCV 947
+C L +GLEEC LTS CC+ LASVLT +KTL++LNL N L + GV L E+L P+C
Sbjct: 892 DCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECA 951
Query: 948 LKVVGLPLTGLNTQTQQLLMTVKERKPSL 976
L+V+GL T + +TQ LL +ER P+L
Sbjct: 952 LQVLGLRKTDFDEETQALLTAEEERNPNL 980
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 557 bits (1435), Expect = e-158
Identities = 339/1005 (33%), Positives = 542/1005 (53%), Gaps = 28/1005 (2%)
Query: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQM---TKEELANVLP 57
MAES +DF LLWYL+ L +EF FK+ L + + F+L P ++ +KE++A +L
Sbjct: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
Query: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFH 117
Y G+ W + ++F + ++DL K + M+ F L WE T
Sbjct: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
Query: 118 YKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQ 177
F+++ + + L AY + +A V L G GKT ++ +L W +G +W+
Sbjct: 121 EHFYKETMKNEYKELNDAYTA----AARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWK 176
Query: 178 NMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFE 237
+ ++V L E+N + +SL EL+++DWP+ I DI S P+++LFI++ + ++F
Sbjct: 177 DRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFN 236
Query: 238 LNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTT 297
L + ++ L + Q+ P+P++L SLL++KM P LI+ L+
Sbjct: 237 LQL-KADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKL 295
Query: 298 LQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGR 357
L S +++ YF+ FF ++ +A V ++ L LC CW+ CT +K+++++G
Sbjct: 296 LGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGE 355
Query: 358 DFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDL 417
D ++ Q T L+A FL + + + + LK LC LAA G++ T FS DL
Sbjct: 356 DLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDL 415
Query: 418 RCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVP----NYLIPS 473
R G +E++ + +L D + F+HL +QEFC A+ +L+ P N I S
Sbjct: 416 RRNGLSESEGVMWVGMRLL---QRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGS 472
Query: 474 GSREYKEKREQYSDF-NQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHL 532
++ + Q QV F+FG+ +LETSFG+ P+ K ++ L
Sbjct: 473 ITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGF--PLSKDLKQEITQCLESL 530
Query: 533 DR---DPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCC 589
+ D E + LF L+E +E+EFV +++ EV +Y+ + + ++++ +CL +C
Sbjct: 531 SQCEADREAIAFQ-ELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQ 589
Query: 590 HLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGIS 649
HL TL++ V+ IF + I + + LVYWRE+CS+F T ++ + L + + L+ S
Sbjct: 590 HLTTLRMCVENIFPDDSGCI---SDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPS 646
Query: 650 ERILSKALEHSSCKLRTLKLSYVSTASGFE-DLLKALARNRSLTYLSINCTSISLNMFSL 708
IL KAL CKLR KL + S G + +L KA+ N L LS+ TS+S +
Sbjct: 647 LAILCKALAQPVCKLR--KLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRH 704
Query: 709 LHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCD 768
L + L P C+I L L KCD+ + CE+IAS+L L+ L+L NPLR +GM +LC+
Sbjct: 705 LCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCE 764
Query: 769 ALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLL 828
AL H +C L L+L++CCLT C ++ VLL S +L LDL N L++ GV + L
Sbjct: 765 ALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALK 824
Query: 829 FPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPN 888
P C + EL L GCF +SD C+ IA V+ N KL++L++G N+I D G++ LC L+HP+
Sbjct: 825 HPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPH 884
Query: 889 CMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVL 948
C L +GL+ C +T ACC +A+ L KTL LNL L D V L E+L PDC L
Sbjct: 885 CKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCAL 944
Query: 949 KVVGLPLTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGV 993
+++GL +G + +TQ++LM+V+E+ P L W +E + GV
Sbjct: 945 QMLGLHKSGFDEETQKILMSVEEKIPHLTISHGPWIDEEYKIRGV 989
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 515 bits (1326), Expect = e-146
Identities = 322/1001 (32%), Positives = 518/1001 (51%), Gaps = 42/1001 (4%)
Query: 1 MAESDST----DFDLLWYLENLSDKEFQSFKKYLARKILDFK--LPQFPLIQMTKEELAN 54
MA+S S+ DF LL YLE L+ +E +FK +L + P + + +E+LAN
Sbjct: 1 MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLAN 60
Query: 55 VLPISYEGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEAC- 96
++ Y G+ W++ IF M +DLC + G +QEA
Sbjct: 61 LMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVL 120
Query: 97 ------KAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVF 150
+ ++ KF + W+ + F ++ +L+ +D A V
Sbjct: 121 GDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVV 180
Query: 151 LMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDG 210
L G GKT ++ A+L W +G ++Q YV +L EINQ+ S A+LI+KDWP
Sbjct: 181 LQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPST 240
Query: 211 QAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPG 270
+ PI +I+ P LLFI++ D + F E ALC + TQ+ P+ L+ SLL++ M P
Sbjct: 241 EGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPE 300
Query: 271 CWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDE 330
L+++R T +K LK L +S RE Y FF+D++ A + +E
Sbjct: 301 ASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNE 360
Query: 331 ILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYH 390
+L +C+V ++CW CT LK+QM+KG D L CQT T L +++ T G + + +
Sbjct: 361 MLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPN 420
Query: 391 LGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIH 450
L+RLC +AA G++ T F E+LR +G T++DVS +NI+ +++ Y F H
Sbjct: 421 QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH 480
Query: 451 LNVQEFCTAIAFLMAVPNYLIPSGSREYKEKRE-----QYSD--FNQVFTFIFGLLNANR 503
L+VQEF A+ +++ + +++ + Y D Q+ F+FGLLN +R
Sbjct: 481 LHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDR 540
Query: 504 RKILETSFGYQLPM-VDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIV 562
K LE +F ++ + + S + + + D P +L + LF+CLYE +++ F+ +
Sbjct: 541 VKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQL-GFLELFHCLYETQDKAFISQAM 599
Query: 563 DALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQN---KEPLIRPTASQMKSL 619
+V + + ++VS +CL +C LRT++LSV +F+ K L T +
Sbjct: 600 RCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRIT 659
Query: 620 VYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFE 679
W+++CS+ +T E LREL ++ ++L+ + IL L H +CKL+ L L +++ G +
Sbjct: 660 HCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQ 719
Query: 680 DLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIA 739
D+ +L N++L +L + + I N L + L P C++ L L C+L C I+
Sbjct: 720 DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNIS 779
Query: 740 SLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVL 799
+ LI SL L LS+N L DG+ +LC+AL HP C L L L C LTE C L L
Sbjct: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
Query: 800 LFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATN 859
+ + L L L N L + GV ++ L C L+ L L C F+S +Y++ + N
Sbjct: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899
Query: 860 EKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTL 919
+ L L++GSN ++D G++LLC RHP+C L ++ L C+LT+ACC LASV+ N L
Sbjct: 900 KSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
Query: 920 ERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
L+L N L +DGV L ++L P+C ++ +GL GL +
Sbjct: 960 RSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
Score = 125 bits (315), Expect = 2e-28
Identities = 83/250 (33%), Positives = 122/250 (48%), Gaps = 2/250 (0%)
Query: 731 RASEC-EEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTE 789
R + C +++ S+L + LR+L L + L MNIL L HPNC L L+L F +
Sbjct: 657 RITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD 716
Query: 790 NCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDIC 849
C + L+ + L LDL + + + GV + L P C+L+ L L C + C
Sbjct: 717 GC-QDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCC 775
Query: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
I+ + ++ L L + +N + D G+QLLC LRHP C L + LE C LT A C L
Sbjct: 776 LNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835
Query: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
+ L +NK L L L N LG+ GV + ++L C LK + L + + + L T
Sbjct: 836 SLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTS 895
Query: 970 KERKPSLIFL 979
SL L
Sbjct: 896 LLHNKSLTHL 905
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 418 bits (1075), Expect = e-116
Identities = 270/867 (31%), Positives = 440/867 (50%), Gaps = 21/867 (2%)
Query: 100 MRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGK 159
M+ + + W++ ++ K H + R+ S D LQ D A + L+G GK
Sbjct: 184 MKAELLETWDNISWPKDHV-YIRNTSKDEHEELQRLLDPNRT-RAQAQTIVLVGRAGVGK 241
Query: 160 TIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILS 219
T + A+L W G ++Q SYV +L+ H+I M ++ AELI+ DWPD API + +S
Sbjct: 242 TTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMS 301
Query: 220 DPKKLLFILEDLDNIRFELNVNES----ALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLI 275
P+KLLFI++ + I + +ES + C++ Q++P+ +L SLLK+++ P LI
Sbjct: 302 QPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLI 361
Query: 276 SSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGL 335
+ + ++K L + +YF F D LQ + ++E L
Sbjct: 362 TIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHS 421
Query: 336 CRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLK 395
C ++CW C+ LK+ + D Q QT T L+A+F ++ ++ A+ G +
Sbjct: 422 CSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWR 481
Query: 396 RLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQE 455
LC LA GL+ F+ ED G + L NIL N F HL+ QE
Sbjct: 482 ALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQE 541
Query: 456 FCTAIAFLMAVPNYLIPSGSREYKEKR-------EQYSDFNQVFTFIFGLLNANRRKILE 508
F A++F++ P P ++ + K ++ + + V F FGLLN N + LE
Sbjct: 542 FFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELE 601
Query: 509 TSFGYQLP---MVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDAL 565
+ ++ M + KW G H + LF+CL+E++EE+F K ++ +
Sbjct: 602 DTLHCKISPRVMEELLKW---GEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRI 658
Query: 566 MEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREI 625
EV + + D+++ S +CL +C L L+LSV ++ I T+ + W I
Sbjct: 659 FEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSI 718
Query: 626 CSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKAL 685
CS T E+L EL + ++ L+ S + L AL++ CK++ L V+ +DL+ AL
Sbjct: 719 CSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIAL 778
Query: 686 ARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISG 745
N LT+L+ + + + + +L + H C + +L L KC+L A+ C+++A L S
Sbjct: 779 QGNSKLTHLNFSSNKLGMTVPLILKALRHS-ACNLKYLCLEKCNLSAASCQDLALFLTSI 837
Query: 746 GSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTL 805
+ +L L N L+ DG+ +LC AL HP C L L L FC L C L LL + +L
Sbjct: 838 QHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSL 897
Query: 806 RQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSL 865
L+L N L++ GV + L P L+ L+LSGC F+ + C +A ++ N ++ L
Sbjct: 898 THLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKIL 957
Query: 866 EIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLL 925
++G N ++D G++LLC L+ P+ L +GL +C LT+ACC+ L SVL+++K+L LNLL
Sbjct: 958 DLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLL 1016
Query: 926 QNHLGNDGVAKLLESLISPDCVLKVVG 952
N L DGV L ++L C L+ +G
Sbjct: 1017 GNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 104 bits (259), Expect = 5e-22
Identities = 99/389 (25%), Positives = 166/389 (42%), Gaps = 52/389 (13%)
Query: 594 LKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLN-GISERI 652
+K+ +Q + +KE YW + F+ + + ++ L+ IS R+
Sbjct: 566 MKMLLQHVLLDKE-------------AYWTPVVLFFFGLLNKNIARELEDTLHCKISPRV 612
Query: 653 LSKAL---------EHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSI------- 696
+ + L E +S + L+L + S ED K + L+I
Sbjct: 613 MEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQ 672
Query: 697 -------NCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLR 749
+C ++ S+ IL + L K D R I S L++ +L
Sbjct: 673 ASSFCLKHCKRLNKLRLSVSSHILER---DLEILETSKFDSRMHAWNSICSTLVTNENLH 729
Query: 750 KLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLD 809
+L LS++ L + + LC AL +P C + L E L L + L L+
Sbjct: 730 ELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCK-SVTPEWVLQDLIIALQGNSKLTHLN 788
Query: 810 LCVNRLKNYGVLHVTFPLLFPT-----CQLEELHLSGCFFSSDICQYIAIVIATNEKLRS 864
N+L +T PL+ C L+ L L C S+ CQ +A+ + + + +
Sbjct: 789 FSSNKLG------MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTR 842
Query: 865 LEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNL 924
L +G N+++D G++LLC L HP C L + L C L + C+ L+ L N++L LNL
Sbjct: 843 LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNL 902
Query: 925 LQNHLGNDGVAKLLESLISPDCVLKVVGL 953
+N L ++GV L E+L PD L+ + L
Sbjct: 903 SKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
Score = 32.3 bits (72), Expect = 2.4
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 12/97 (12%)
Query: 7 TDFDLLWYLENLSDKEFQSFKKYLA-RKILDF-KLPQ--FPLIQMTKEELANVLPISY-- 60
T+ LL YL L + + FK L ++++DF PQ FP I A+ L +S+
Sbjct: 13 TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL 72
Query: 61 -----EGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRN 92
+GQ W ++ IF M LC K+ N
Sbjct: 73 DEHFPKGQ-AWKVVLGIFQTMNLTSLCEKVRAEMKEN 108
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 391 bits (1005), Expect = e-108
Identities = 292/1051 (27%), Positives = 476/1051 (45%), Gaps = 97/1051 (9%)
Query: 14 YLENLSDKEFQSFKKYL--ARKILDFKLPQFPLIQMTKEELANVLPISYEGQYIWNMLFS 71
YLE L E + FK YL A ++ + K+P + + E+A +L + + W + S
Sbjct: 16 YLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
Query: 72 IFSMMRKEDLCRK-----------------------------IIGRRNRNQEACKAVMRR 102
F + ++DL + ++ R QE + +RR
Sbjct: 76 TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRR 135
Query: 103 KFMLQWE-----------SHTF----------------------GKFHYKFFRDVSSDVF 129
KF L + SH + G+ H + +S +
Sbjct: 136 KFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIK 195
Query: 130 YILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAH 189
++ ++ V + G GK+++ + +L W G+++Q Y+ ++
Sbjct: 196 --IETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCR 253
Query: 190 EINQM-TNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSN 248
E+NQ T S+ +LI WP+ AP+ +++ P++LLFI++ D ++ + + C
Sbjct: 254 EMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLC 313
Query: 249 STQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIY 308
+K P +LL SL+++K+ P LI++RPT + L+ L S +R+ Y
Sbjct: 314 WEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEY 373
Query: 309 FNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTD 368
F +F + ++A V ++E L +C V ++CW+ CT L++Q++ G + +T T
Sbjct: 374 FYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTA 433
Query: 369 LHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
++ +L + + G Q + LC LAA GL+ + F +DLR G DVS
Sbjct: 434 VYMLYLLSLMQPKPGAPRLQPPPNQ-RGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVS 492
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLM------AVPNYLIPSGSREYKEKR 482
NI + Y FIHL+ QEF A+ +++ A P+ + EY
Sbjct: 493 AFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSE 552
Query: 483 EQYSDFNQVFTFIFGLLNANRRKILETSFGYQLP---MVDSFKWYSVGYMKHLDRDPEKL 539
+ F+FGLLN R LE S +++ +D +W D L
Sbjct: 553 RSFLALTS--RFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQ----SKAQSDGSTL 606
Query: 540 TH-HMPLFYCLYENREEEFVKTIVDALMEVTVY-LQSDKDMMVSLYCLDYCCHLRTLKLS 597
+ F CLYE +EEEF++ + + V + S + MVS +CL C + L L
Sbjct: 607 QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
Query: 598 VQRIFQNKEPLIRPTASQMKSLV-----------YWREICSLFYTMESLRELHIFDNDLN 646
+ E R +A LV Y + + T +L EL ++ N L
Sbjct: 667 GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALG 726
Query: 647 GISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNM 705
++L + L H +CKL+ L+L ++S EDL AL N++LT + ++ +
Sbjct: 727 SRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPG 786
Query: 706 FSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNI 765
LL + L P C++ + L KC L + C+E+AS+L + L +L L+ N L G+ +
Sbjct: 787 MMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRL 846
Query: 766 LCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTF 825
LC L HP C L +L L C LT C L L + +LR+LDL +N L + GVL +
Sbjct: 847 LCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCE 906
Query: 826 PLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLR 885
L PTC+L+ L L C S C+ +++V+ N LR L++ N + D G+ LL GL+
Sbjct: 907 GLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQ 966
Query: 886 HPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPD 945
HP C L + L+ C LT+ C +L L N+TL L L N LG+ GV L + L P
Sbjct: 967 HPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPG 1026
Query: 946 CVLKVVGLPLTGLNTQTQQLLMTVKERKPSL 976
C L+V+ L LN T L ++ KP L
Sbjct: 1027 CKLRVLWLFGMDLNKMTHSRLAALRVTKPYL 1057
Score = 138 bits (347), Expect = 3e-32
Identities = 89/289 (30%), Positives = 140/289 (48%), Gaps = 1/289 (0%)
Query: 633 ESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGF-EDLLKALARNRSL 691
++L + + N + +L + L H C+L+ ++L SG +++ L N L
Sbjct: 770 KNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHL 829
Query: 692 TYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKL 751
L + ++ LL L P C++ L L C L A+ C+E+AS L SLR+L
Sbjct: 830 VELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLREL 889
Query: 752 TLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLC 811
LS N L G+ +LC+ L HP C L +L L C L C L VL + LR+LDL
Sbjct: 890 DLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
Query: 812 VNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNK 871
N L ++G+ + L P C+L++L L C ++ C+ + + N+ L L + +N
Sbjct: 950 FNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNA 1009
Query: 872 IEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLE 920
+ D G++LLC L HP C L + L L LA++ T L+
Sbjct: 1010 LGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLD 1058
Score = 92.0 bits (227), Expect = 3e-18
Identities = 57/172 (33%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
+++A + TN L L + N + G++LLC GLRHPNC L N+ L+ C ++S+ C L
Sbjct: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
Query: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
++ L NK L R++L N +G G+ L E L P C L+++ L L + Q + +V
Sbjct: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
Query: 970 KERKPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAA 1021
P L+ L T + E ++G+ Q G P L ++ K R++AA
Sbjct: 823 LGTNPHLVELDLTGNALE--DLGLRLLCQ-GLRHPVCRLRTLWLKICRLTAA 871
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 382 bits (982), Expect = e-106
Identities = 267/870 (30%), Positives = 413/870 (47%), Gaps = 61/870 (7%)
Query: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
Query: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
Query: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
Query: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
Query: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
Query: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 621 LQIQPSQLE----LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
Query: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
+L L +E R L + L S
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEG----------------------RHLDMVQCVLPSSSHA 714
Query: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
S L +S T+S L L+ ++SLT L ++ S+ +L +
Sbjct: 715 ACSHGLVNSHL-----------TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCE 763
Query: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
L P C I L L +C L C +I+ +L S L +L LS N L G+ +LC L
Sbjct: 764 TLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823
Query: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
H C L L LV CCLT CC L VL S +L +L + N L + GV + P
Sbjct: 824 HLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ 883
Query: 832 CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891
C L++L L +S C ++ V++TN+ L L + N + D G++LLC GL HP+C L
Sbjct: 884 CNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKL 943
Query: 892 VNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVV 951
+ L+ C LTS CC L+++LT++++L +L+L N LG+ GV E L C+L+ +
Sbjct: 944 QVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNL 1003
Query: 952 GLPLTGLNTQTQQLLMTVKERKPSLIFLSE 981
GL N +T+ L T++E KP L + E
Sbjct: 1004 GLSEMYFNYETKSALETLQEEKPELTVVFE 1033
Score = 163 bits (412), Expect = 9e-40
Identities = 104/300 (34%), Positives = 154/300 (51%), Gaps = 6/300 (2%)
Query: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
L+ L +S C + S+L + SL +L LS N L GM +LC+ L HP C + L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
C L+ CC + VL + L +LDL N L ++G+ + L C L++L L C
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
+S CQ +A V++T+ L L +G N + D+G+ +LC ++P C L +GL LTS
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
CC +L+SVL+TN+ L L L N LG+ G+ L E L+ PDC L+V+ L L +
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 959
Query: 965 LLMTVKERKPSLIFLSETWSLKEGREIGV----TPASQPGSIIPNSNLDYMFFKFPRMSA 1020
L T+ SL LS + ++GV Q ++ N L M+F + SA
Sbjct: 960 DLSTLLTSSQSLRKLS--LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 1017
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 382 bits (982), Expect = e-106
Identities = 267/870 (30%), Positives = 413/870 (47%), Gaps = 61/870 (7%)
Query: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
Query: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
Query: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
Query: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
Query: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
Query: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 621 LQIQPSQLE----LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
Query: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
+L L +E R L + L S
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEG----------------------RHLDMVQCVLPSSSHA 714
Query: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
S L +S T+S L L+ ++SLT L ++ S+ +L +
Sbjct: 715 ACSHGLVNSHL-----------TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCE 763
Query: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
L P C I L L +C L C +I+ +L S L +L LS N L G+ +LC L
Sbjct: 764 TLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823
Query: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
H C L L LV CCLT CC L VL S +L +L + N L + GV + P
Sbjct: 824 HLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ 883
Query: 832 CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891
C L++L L +S C ++ V++TN+ L L + N + D G++LLC GL HP+C L
Sbjct: 884 CNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKL 943
Query: 892 VNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVV 951
+ L+ C LTS CC L+++LT++++L +L+L N LG+ GV E L C+L+ +
Sbjct: 944 QVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNL 1003
Query: 952 GLPLTGLNTQTQQLLMTVKERKPSLIFLSE 981
GL N +T+ L T++E KP L + E
Sbjct: 1004 GLSEMYFNYETKSALETLQEEKPELTVVFE 1033
Score = 163 bits (412), Expect = 9e-40
Identities = 104/300 (34%), Positives = 154/300 (51%), Gaps = 6/300 (2%)
Query: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
L+ L +S C + S+L + SL +L LS N L GM +LC+ L HP C + L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
C L+ CC + VL + L +LDL N L ++G+ + L C L++L L C
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
+S CQ +A V++T+ L L +G N + D+G+ +LC ++P C L +GL LTS
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
CC +L+SVL+TN+ L L L N LG+ G+ L E L+ PDC L+V+ L L +
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 959
Query: 965 LLMTVKERKPSLIFLSETWSLKEGREIGV----TPASQPGSIIPNSNLDYMFFKFPRMSA 1020
L T+ SL LS + ++GV Q ++ N L M+F + SA
Sbjct: 960 DLSTLLTSSQSLRKLS--LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 1017
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 370 bits (949), Expect = e-102
Identities = 245/838 (29%), Positives = 424/838 (50%), Gaps = 25/838 (2%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G+ GK+ + VL W +G ++Q M SYV L E+ + SS+ E I+++WP
Sbjct: 282 VVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWP 341
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
D QAP+ +I+S P++LLFI++ D++ LN N++ LC + +K P L+ SLL++ +
Sbjct: 342 DSQAPVTEIMSRPERLLFIIDGFDDLGSVLN-NDTKLCKDWAEKQPPFTLIRSLLRKVLL 400
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKR-EIYFNSFFKDRQRASAALQLVH 327
P + +++ R +K+ + +S +R + + Q+ +++
Sbjct: 401 PESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMN 460
Query: 328 EDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTA- 386
E+L C+V + + C L+ Q G QT T LHA F+ LT +
Sbjct: 461 NRELL-DQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRC 519
Query: 387 -NQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDR 445
N +LKR C +A G++ F G+DL G E+++ L NILLP + ++
Sbjct: 520 LNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEY 579
Query: 446 YKFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQ---------VFTFIF 496
Y F HL++Q+FC A+ +++ + P+ Y EK ++ + Q + F+F
Sbjct: 580 YTFFHLSLQDFCAALYYVLEGLE-IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLF 638
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLT--HHMPLFYCLYENRE 554
GL++ + R+ LE G +P+ K + ++ L + P T + F+CL+E ++
Sbjct: 639 GLVSEDVRRPLEVLLGCPVPL--GVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQD 696
Query: 555 EEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPL----IR 610
+EFV+ +++ EV + + + D++ S +CL +C +LR +++ V+ IF E +
Sbjct: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVV 756
Query: 611 PTASQMKSLV--YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLK 668
P + K+L+ W + CS+ T LR+L + + L + + L L H +CK++TL
Sbjct: 757 PLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLM 816
Query: 669 LSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKC 728
G + L + + NR+L L++ T + + + L P C + L L C
Sbjct: 817 FRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCC 876
Query: 729 DLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLT 788
L + +I+ +L + SL+ L+L+ N + G+ L DAL C L L+L C +T
Sbjct: 877 GLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGIT 936
Query: 789 ENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDI 848
C +L L+ + +L L L N L N GV + + P C L+ L L+ C +
Sbjct: 937 ATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAG 996
Query: 849 CQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRS 908
C ++A+ + N L L + N +ED G++LLC +R P+C L ++ L +C LT+ACC S
Sbjct: 997 CGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCES 1056
Query: 909 LASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
L+ V++ ++ L+ L+L N LG+ GVA L E L + VL +GL GL + + L
Sbjct: 1057 LSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
Score = 39.3 bits (90), Expect = 0.019
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 3/81 (3%)
Query: 7 TDFDLLWYLENLSDKEFQSFKKYLARKILD---FKLPQFPLIQMTKEELANVLPISYEGQ 63
+ + L W L L +EFQ+FK+ L +K + +PQF + E LA +L Y
Sbjct: 61 SSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGAS 120
Query: 64 YIWNMLFSIFSMMRKEDLCRK 84
W SIF M L K
Sbjct: 121 LAWATSISIFENMNLRTLSEK 141
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 366 bits (940), Expect = e-101
Identities = 267/923 (28%), Positives = 426/923 (46%), Gaps = 55/923 (5%)
Query: 87 GRRNRNQEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANN 146
G++ C+ +++ KF W+S + V ++ + +L + +
Sbjct: 151 GKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQ----VMAERYKMLIPFSNPRVLPGPFS 206
Query: 147 LNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKD 206
V L G GKT + +L W + + Y +L+ E++++ S AEL+ +D
Sbjct: 207 YTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKF-KYAFYLSCRELSRLGPCSFAELVFRD 265
Query: 207 WPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRK 266
WP+ Q I IL+ +K+LF+++ D + +C + +K P+PVLL SLL R
Sbjct: 266 WPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRV 325
Query: 267 MAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLV 326
M P L+++RP +++ +E R YF F D +A A +L+
Sbjct: 326 MLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELM 385
Query: 327 HEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTA 386
+ L L +CWI CT LK QM+KG D C T T L FL A L
Sbjct: 386 RSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR- 444
Query: 387 NQYHLGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRY 446
G L+ L LLAA GL+ T EDL +G E+D+ + +IL K Y
Sbjct: 445 -----GALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCY 499
Query: 447 KFIHLNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYS-------------------D 487
FIHL+ Q+F TA+ + + +E +E R+ ++ D
Sbjct: 500 SFIHLSFQQFLTALFYTL----------EKEEEEDRDGHTWDIGDVQKLLSGVERLRNPD 549
Query: 488 FNQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFY 547
Q + FGL N R K LE +FG + M K + +T L
Sbjct: 550 LIQAGYYSFGLANEKRAKELEATFGCR--MSPDIKQELLRCDISCKGGHSTVTDLQELLG 607
Query: 548 CLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEP 607
CLYE++EEE VK ++ E++++L + D++ S +C+ +C +L+ K+S+Q I +N
Sbjct: 608 CLYESQEEELVKEVMAQFKEISLHLNA-VDVVPSSFCVKHCRNLQ--KMSLQVIKENLPE 664
Query: 608 LIRPTASQMK---------SLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALE 658
+ + S + L +W ++CS+F + + L L I D+ L+ RIL + +
Sbjct: 665 NVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIA 724
Query: 659 HSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTC 718
+C L+ + +S A +L AL ++++TYL++ +MF L ++L P C
Sbjct: 725 SDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQD-DMFPALCEVLRHPEC 783
Query: 719 QISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLI 778
+ +L L+ C + +++ L SL + LS N L +G +L L HP C L
Sbjct: 784 NLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQ 843
Query: 779 SLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELH 838
L L C LTE C L VL+ S L L L N + N GV + L +P C+L+ L
Sbjct: 844 RLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLV 903
Query: 839 LSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEE 898
L C +SD C + ++ L L++G N I GM+ LC LR P C L + L
Sbjct: 904 LWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWG 963
Query: 899 CMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGL 958
C + C L S L+ N++L L+L QN LG+ GV L E+L L+ + L +
Sbjct: 964 CSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
Query: 959 NTQTQQLLMTVKERKPSLIFLSE 981
N + +LL ++E+ P LI +E
Sbjct: 1024 NDELNKLLEEIEEKNPQLIIDTE 1046
Score = 31.2 bits (69), Expect = 5.3
Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLP 57
M S F+L LE LS E FK + L +L + P ++ K ++L +L
Sbjct: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
Query: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRK 103
+ ++ +F M + DL + + + A K+ +RK
Sbjct: 61 THCDSYWVEMASLQVFEKMHRMDLSER--AKDEVREAALKSFNKRK 104
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 360 bits (925), Expect = 3e-99
Identities = 297/1030 (28%), Positives = 464/1030 (45%), Gaps = 71/1030 (6%)
Query: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
Query: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
+I N +I M +LC+ +G + E K +
Sbjct: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
Query: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
K L W++ TF + F D DV Q + + L V L G
Sbjct: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
Query: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
Query: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
Query: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
Query: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
Query: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
Query: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Query: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
Query: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR--------------IFQNKEPLI 609
E++++L + ++M + L +C L+ L L V + F+ L
Sbjct: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT 649
Query: 610 RP--TASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTL 667
P ++SL W + CSLF + +L+ L + + L+ S RIL + S+C L+ +
Sbjct: 650 IPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKV 709
Query: 668 KLSYVSTASGFEDLLKALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLM 726
++ V+ + + D A ++LT+L++ M +L D+L C + +L L
Sbjct: 710 EIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLG 769
Query: 727 KCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCC 786
+ E +L + SL+ L LS+N L +G +L + P L L L C
Sbjct: 770 GHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCR 829
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
LTE C L VL+ S L L L N + + GV + L +P C+L+ L L C +
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
C+Y++ + L +L++ N+I G+ +LC L +PNC L ++ L C L C
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
+ L S L +N+ LE L+L QNHL G+ KL L LK++ L N + ++LL
Sbjct: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLL 1008
Query: 967 MTVKERKPSL 976
VKE+ P L
Sbjct: 1009 EEVKEKNPKL 1018
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 343 bits (881), Expect = 4e-94
Identities = 288/1015 (28%), Positives = 457/1015 (45%), Gaps = 69/1015 (6%)
Query: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
Query: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
+I N +I M +LC+ +G + E K +
Sbjct: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
Query: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
K L W++ TF + F D DV Q + + L V L G
Sbjct: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
Query: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
Query: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
Query: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
Query: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
Query: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
Query: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Query: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
Query: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR-IFQNKEPLIRPTASQMKSLVYW 622
E++++L + ++M + L +C L+ L L V + +F +++ + +
Sbjct: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF-------------LENYMDF 636
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
+ +L+ L + + L+ S RIL + S+C L+ +++ V+ + + D
Sbjct: 637 ELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFC 696
Query: 683 KALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
A ++LT+L++ M +L D+L C + +L L + E +
Sbjct: 697 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 756
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + SL+ L LS+N L +G +L + P L L L C LTE C L VL+
Sbjct: 757 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 816
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
S L L L N + + GV + L +P C+L+ L L C + C+Y++ +
Sbjct: 817 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 876
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L +L++ N+I G+ +LC L +PNC L ++ L C L C+ L S L +N+ LE
Sbjct: 877 LTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLET 935
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSL 976
L+L QNHL G+ KL L LK++ L N + ++LL VKE+ P L
Sbjct: 936 LDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 329 bits (844), Expect = 7e-90
Identities = 234/787 (29%), Positives = 365/787 (46%), Gaps = 61/787 (7%)
Query: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
Query: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
Query: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
Query: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
Query: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
Query: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 621 LQIQPSQLE----LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
Query: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
+L L +E R L + L S
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEG----------------------RHLDMVQCVLPSSSHA 714
Query: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
S L +S T+S L L+ ++SLT L ++ S+ +L +
Sbjct: 715 ACSHGLVNSHL-----------TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCE 763
Query: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
L P C I L L +C L C +I+ +L S L +L LS N L G+ +LC L
Sbjct: 764 TLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823
Query: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
H C L L LV LT CCSAL VL + L L L N L + G+ + LL P
Sbjct: 824 HLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 883
Query: 832 CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891
C+L+ L L C +S C ++ ++ +++ LR L +G+N + D G+ + C L+ +C+L
Sbjct: 884 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 943
Query: 892 VNIGLEE 898
N+GL E
Sbjct: 944 QNLGLSE 950
Score = 162 bits (410), Expect = 2e-39
Identities = 93/257 (36%), Positives = 143/257 (55%)
Query: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
L+ L +S C + S+L + SL +L LS N L GM +LC+ L HP C + L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
C L+ CC + VL + L +LDL N L ++G+ + L C L++L L
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 839
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
+S C ++ V++TN+ L L + N + D G++LLC GL HP+C L + L+ C LTS
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
CC L+++LT++++L +L+L N LG+ GV E L C+L+ +GL N +T+
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 965 LLMTVKERKPSLIFLSE 981
L T++E KP L + E
Sbjct: 960 ALETLQEEKPELTVVFE 976
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/65 (41%), Positives = 40/65 (61%)
Query: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
GL LTS+ CR L SVL+T+++L L+L N LG+ G+ L E+L P C ++ + L
Sbjct: 719 GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLG 778
Query: 955 LTGLN 959
GL+
Sbjct: 779 RCGLS 783
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 323 bits (829), Expect = 4e-88
Identities = 227/787 (28%), Positives = 366/787 (46%), Gaps = 61/787 (7%)
Query: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
Query: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
Query: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
Query: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
Query: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
Query: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 621 LQIQPSQLE----LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
Query: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
+L L +E + + C L + + S
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDMVQ-----CVLPSSSHA------------ACSHG 719
Query: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
+ L H C D+ L+ N+ L L ++ ++ LL
Sbjct: 720 LGRCGLSHECCF----------------DISLVLSSNQKLVELDLSDNALGDFGIRLLCV 763
Query: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
L C + L L+ C L ++ C+++AS+L + SL +L + N L G+ ILC+
Sbjct: 764 GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 823
Query: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
+P C L L LV LT CCSAL VL + L L L N L + G+ + LL P
Sbjct: 824 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 883
Query: 832 CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891
C+L+ L L C +S C ++ ++ +++ LR L +G+N + D G+ + C L+ +C+L
Sbjct: 884 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 943
Query: 892 VNIGLEE 898
N+GL E
Sbjct: 944 QNLGLSE 950
Score = 160 bits (404), Expect = 8e-39
Identities = 96/257 (37%), Positives = 141/257 (54%)
Query: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
L +C L C +I+ +L S L +L LS N L G+ +LC L H C L L LV
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
CCLT CC L VL S +L +L + N L + GV + P C L++L L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
+S C ++ V++TN+ L L + N + D G++LLC GL HP+C L + L+ C LTS
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
CC L+++LT++++L +L+L N LG+ GV E L C+L+ +GL N +T+
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 965 LLMTVKERKPSLIFLSE 981
L T++E KP L + E
Sbjct: 960 ALETLQEEKPELTVVFE 976
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/82 (34%), Positives = 40/82 (48%)
Query: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
GL C L+ CC ++ VL++N+ L L+L N LG+ G+ L L C LK + L
Sbjct: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLV 778
Query: 955 LTGLNTQTQQLLMTVKERKPSL 976
L + Q L +V SL
Sbjct: 779 SCCLTSACCQDLASVLSTSHSL 800
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 320 bits (820), Expect = 4e-87
Identities = 255/965 (26%), Positives = 417/965 (43%), Gaps = 97/965 (10%)
Query: 11 LLWYLENLSDKEFQSFKKYLARKILDFKLP-QFPLIQMTK-EELANVLPISYEGQYIWNM 68
++ Y+ N+S +E Q FK+ L ++ +P + ++ E+ ++L + G+ W++
Sbjct: 41 VMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDV 100
Query: 69 LFSIFSMMRKEDLCRKIIGRRNRN--------------------QEACKAVMRR------ 102
+IF++M + +C ++ RR N +E +RR
Sbjct: 101 TSNIFAIMNCDKMC--VVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVM 158
Query: 103 -KFMLQWESHTF-GKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKT 160
KF W+ T+ G F++ V Y+ L V + G GKT
Sbjct: 159 EKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQ-GRQPKTVAIQGAPGIGKT 217
Query: 161 IVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSD 220
I+ + W + + + + + E+NQ T+ S +ELI + WP Q ++ I+S
Sbjct: 218 ILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSK 277
Query: 221 PKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPT 280
P +LL +L+ + + L L + QK+P VLL SLL + M P LI R T
Sbjct: 278 PDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFT 337
Query: 281 RGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAI 340
K LK T + ++ YF +F + L E+ IL +CRV +
Sbjct: 338 SWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPV 397
Query: 341 LCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLL 400
+CW+ C+ LK+QM++G + C T + +++ + A + + H L+ LC L
Sbjct: 398 VCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHL 457
Query: 401 AAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAI 460
AA ++ EDL + V+ +IL +D Y F + QEF A+
Sbjct: 458 AADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAAL 517
Query: 461 AFLMAVP----NYLIPSG---SREYKEKREQYSDFNQVFTFIFGLLNANRRKILETSFGY 513
+++ P N+ + S R R S + + F+FG LN +E SF
Sbjct: 518 FYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQC 577
Query: 514 QLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQ 573
++ + K V + H P + LFYCL+E REE FV ++ +V + +
Sbjct: 578 KVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIG 637
Query: 574 SDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPT-----ASQMKSL-VYWREICS 627
++K++ VS +CL C +L ++L+V F N L + A + L +W+++CS
Sbjct: 638 NNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCS 697
Query: 628 LFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALAR 687
+F T + L L + ++ L + L+ AL H CKL+ L L V++ +DL+ L
Sbjct: 698 VFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTG 757
Query: 688 NRSLTYLSINCTSISLNMFSLLHDILHEPTC----------------------------- 718
N+ L YL I + LL +L P C
Sbjct: 758 NQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGH 817
Query: 719 ----------------------QISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSN 756
Q+ LS+ C+L CE +AS L L L+L+ N
Sbjct: 818 LKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAEN 877
Query: 757 PLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLK 816
L+ +G + +AL H C L LVL C LT NCC + L + TL+ LDL N LK
Sbjct: 878 ALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLK 937
Query: 817 NYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAG 876
+ GV+ + L P C L+ L L C F+S CQ +A ++ N+ LR L++ N I G
Sbjct: 938 DDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYG 997
Query: 877 MQLLC 881
+ LC
Sbjct: 998 ILTLC 1002
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 315 bits (808), Expect = 1e-85
Identities = 267/951 (28%), Positives = 424/951 (44%), Gaps = 71/951 (7%)
Query: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
Query: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
+I N +I M +LC+ +G + E K +
Sbjct: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
Query: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
K L W++ TF + F D DV Q + + L V L G
Sbjct: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
Query: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
Query: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
Query: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
Query: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
Query: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
Query: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Query: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
Query: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR--------------IFQNKEPLI 609
E++++L + ++M + L +C L+ L L V + F+ L
Sbjct: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT 649
Query: 610 RP--TASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTL 667
P ++SL W + CSLF + +L+ L + + L+ S RIL + S+C L+ +
Sbjct: 650 IPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKV 709
Query: 668 KLSYVSTASGFEDLLKALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLM 726
++ V+ + + D A ++LT+L++ M +L D+L C + +L L
Sbjct: 710 EIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLG 769
Query: 727 KCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCC 786
+ E +L + SL+ L LS+N L +G +L + P L L L C
Sbjct: 770 GHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCR 829
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
LTE C L VL+ S L L L N + + GV + L +P C+L+ L L C +
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLE 897
C+Y++ + L +L++ N+I G+ +LC L +PNC L ++ L+
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 281 bits (718), Expect = 3e-75
Identities = 209/734 (28%), Positives = 333/734 (45%), Gaps = 61/734 (8%)
Query: 132 LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191
++L +D +S V G GKTI+ +L W G ++Q+ Y+ ++ E+
Sbjct: 205 MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
Query: 192 NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251
+ +T SL +LI PD PI I+ P ++LF+++ D ++ + + LC++ +
Sbjct: 265 SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
Query: 252 KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311
+LL SL+++K+ P LI++RP ++ L L S KR+ YF
Sbjct: 325 AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
Query: 312 FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371
+F D +A AA L+ E+E+L +C + ++CWI CT LK+QM+ G+ +T T ++
Sbjct: 385 YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 372 HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428
FL+ L G +Q H GL L LC LAA G++ + F DLR G +ADVS
Sbjct: 445 FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
Query: 429 VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480
N+ + Y FIH+ QEF A+ +L+ VP + SR+
Sbjct: 501 AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
Query: 481 KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531
E Y F + V F+FGL+N R LE ++ ++ KW V K
Sbjct: 561 LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
Query: 532 LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591
L P +L LFYCLYE +EE+FV+ +D ++ + L + D MVS +C++ C +
Sbjct: 621 LQIQPSQLE----LFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
Query: 592 RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651
+L L +E + + C L + + S
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDMVQ-----CVLPSSSHA------------ACSHG 719
Query: 652 ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711
+ L H C D+ L+ N+ L L ++ ++ LL
Sbjct: 720 LGRCGLSHECCF----------------DISLVLSSNQKLVELDLSDNALGDFGIRLLCV 763
Query: 712 ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771
L C + L L+ L + C ++S+L + +L L L N L G+ +LC+ LL
Sbjct: 764 GLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 823
Query: 772 HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831
HP+C L L L C LT +CC L +L S +LR+L L N L + GV+ L +
Sbjct: 824 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 883
Query: 832 CQLEELHLSGCFFS 845
C L+ L LS +F+
Sbjct: 884 CLLQNLGLSEMYFN 897
Score = 124 bits (312), Expect = 4e-28
Identities = 70/197 (35%), Positives = 111/197 (56%)
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
C L+ CC + VL + L +LDL N L ++G+ + L C L++L L
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904
+S C ++ V++TN+ L L + N + D G++LLC GL HP+C L + L+ C LTS
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 905 CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964
CC L+++LT++++L +L+L N LG+ GV E L C+L+ +GL N +T+
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902
Query: 965 LLMTVKERKPSLIFLSE 981
L T++E KP L + E
Sbjct: 903 ALETLQEEKPELTVVFE 919
Score = 107 bits (266), Expect = 8e-23
Identities = 63/174 (36%), Positives = 93/174 (53%)
Query: 725 LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784
L +C L C +I+ +L S L +L LS N L G+ +LC L H C L L LV
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 785 CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844
LT CCSAL VL + L L L N L + G+ + LL P C+L+ L L C
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 845 SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEE 898
+S C ++ ++ +++ LR L +G+N + D G+ + C L+ +C+L N+GL E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 99.4 bits (246), Expect = 2e-20
Identities = 65/186 (34%), Positives = 97/186 (52%), Gaps = 6/186 (3%)
Query: 839 LSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEE 898
L C S + C I++V+++N+KL L++ N + D G++LLC GL+H C L + L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 899 CMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGL 958
LTS CC +L+SVL+TN+ L L L N LG+ G+ L E L+ PDC L+V+ L L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 959 NTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGV----TPASQPGSIIPNSNLDYMFFK 1014
+ L T+ SL LS + ++GV Q ++ N L M+F
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLS--LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFN 897
Query: 1015 FPRMSA 1020
+ SA
Sbjct: 898 YETKSA 903
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/85 (32%), Positives = 42/85 (49%)
Query: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
GL C L+ CC ++ VL++N+ L L+L N LG+ G+ L L C LK + L
Sbjct: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLV 778
Query: 955 LTGLNTQTQQLLMTVKERKPSLIFL 979
+GL + L +V +L L
Sbjct: 779 NSGLTSVCCSALSSVLSTNQNLTHL 803
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 250 bits (639), Expect = 4e-66
Identities = 192/652 (29%), Positives = 310/652 (47%), Gaps = 41/652 (6%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
Query: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
Query: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
Query: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
Query: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
Query: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
Query: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L L
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 123 bits (309), Expect = 8e-28
Identities = 72/194 (37%), Positives = 109/194 (56%)
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +GL T L+ + +Q L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 967 MTVKERKPSLIFLS 980
+++ KP L+ S
Sbjct: 972 RALEQEKPQLLIFS 985
Score = 115 bits (289), Expect = 2e-25
Identities = 61/166 (36%), Positives = 93/166 (56%)
Query: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASV 912
+ N ++D G++LLC GLRHP C L+ +GL++ L+ + L ++
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 96.7 bits (239), Expect = 1e-19
Identities = 73/224 (32%), Positives = 104/224 (46%), Gaps = 17/224 (7%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + ++ L L R+L L ++ S+S + L L P C + L L C L A
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
+C+++A L + +L +L LS N L G LC L P+C L L LV C LT +CC
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL SP+L++LDL N L + GV + L P C+L L L S ++
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEM----- 967
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLE 897
++LR+L E QLL R P+ M GL+
Sbjct: 968 -----RQELRAL-------EQEKPQLLIFSRRKPSVMTPTEGLD 999
Score = 38.9 bits (89), Expect = 0.025
Identities = 19/67 (28%), Positives = 36/67 (53%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
+++ S+ SL+EL + N+L+ + R+L + L H +CKL L L + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 683 KALARNR 689
+AL + +
Sbjct: 972 RALEQEK 978
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 250 bits (639), Expect = 4e-66
Identities = 192/652 (29%), Positives = 310/652 (47%), Gaps = 41/652 (6%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
Query: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
Query: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
Query: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
Query: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
Query: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
Query: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L L
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 123 bits (309), Expect = 8e-28
Identities = 72/194 (37%), Positives = 109/194 (56%)
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +GL T L+ + +Q L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 967 MTVKERKPSLIFLS 980
+++ KP L+ S
Sbjct: 972 RALEQEKPQLLIFS 985
Score = 115 bits (289), Expect = 2e-25
Identities = 61/166 (36%), Positives = 93/166 (56%)
Query: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASV 912
+ N ++D G++LLC GLRHP C L+ +GL++ L+ + L ++
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 96.7 bits (239), Expect = 1e-19
Identities = 73/224 (32%), Positives = 104/224 (46%), Gaps = 17/224 (7%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + ++ L L R+L L ++ S+S + L L P C + L L C L A
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
+C+++A L + +L +L LS N L G LC L P+C L L LV C LT +CC
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL SP+L++LDL N L + GV + L P C+L L L S ++
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEM----- 967
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLE 897
++LR+L E QLL R P+ M GL+
Sbjct: 968 -----RQELRAL-------EQEKPQLLIFSRRKPSVMTPTEGLD 999
Score = 38.9 bits (89), Expect = 0.025
Identities = 19/67 (28%), Positives = 36/67 (53%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
+++ S+ SL+EL + N+L+ + R+L + L H +CKL L L + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 683 KALARNR 689
+AL + +
Sbjct: 972 RALEQEK 978
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 250 bits (639), Expect = 4e-66
Identities = 192/652 (29%), Positives = 310/652 (47%), Gaps = 41/652 (6%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
Query: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
Query: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
Query: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
Query: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
Query: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
Query: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L L
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 123 bits (309), Expect = 8e-28
Identities = 72/194 (37%), Positives = 109/194 (56%)
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +GL T L+ + +Q L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 967 MTVKERKPSLIFLS 980
+++ KP L+ S
Sbjct: 972 RALEQEKPQLLIFS 985
Score = 115 bits (289), Expect = 2e-25
Identities = 61/166 (36%), Positives = 93/166 (56%)
Query: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASV 912
+ N ++D G++LLC GLRHP C L+ +GL++ L+ + L ++
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 96.7 bits (239), Expect = 1e-19
Identities = 73/224 (32%), Positives = 104/224 (46%), Gaps = 17/224 (7%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + ++ L L R+L L ++ S+S + L L P C + L L C L A
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
+C+++A L + +L +L LS N L G LC L P+C L L LV C LT +CC
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL SP+L++LDL N L + GV + L P C+L L L S ++
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEM----- 967
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLE 897
++LR+L E QLL R P+ M GL+
Sbjct: 968 -----RQELRAL-------EQEKPQLLIFSRRKPSVMTPTEGLD 999
Score = 38.9 bits (89), Expect = 0.025
Identities = 19/67 (28%), Positives = 36/67 (53%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
+++ S+ SL+EL + N+L+ + R+L + L H +CKL L L + + L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 683 KALARNR 689
+AL + +
Sbjct: 972 RALEQEK 978
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 250 bits (638), Expect = 6e-66
Identities = 191/650 (29%), Positives = 309/650 (47%), Gaps = 41/650 (6%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
Query: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
Query: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
Query: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
Query: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
Query: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
Query: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 111 bits (278), Expect = 3e-24
Identities = 59/154 (38%), Positives = 85/154 (55%)
Query: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900
+ N ++D G++LLC GLRHP C L+ +G M
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVM 962
Score = 109 bits (273), Expect = 1e-23
Identities = 64/168 (38%), Positives = 94/168 (55%)
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +G P
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKP 959
Score = 92.4 bits (228), Expect = 2e-18
Identities = 59/164 (35%), Positives = 83/164 (50%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + ++ L L R+L L ++ S+S + L L P C + L L C L A
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
+C+++A L + +L +L LS N L G LC L P+C L L LV C LT +CC
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEEL 837
L VL SP+L++LDL N L + GV + L P C+L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 70.5 bits (171), Expect = 8e-12
Identities = 42/127 (33%), Positives = 63/127 (49%)
Query: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
Q + V+ L+ L++ N + + ++ LC LR P C+L + L C LT+ C+ L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
A L N+TL L+L N L + G L + L P C L+ + L GL + Q L +V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 970 KERKPSL 976
PSL
Sbjct: 918 LSASPSL 924
Score = 34.7 bits (78), Expect = 0.48
Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKL-RTLKLSYVSTASGFE 679
+++ S+ SL+EL + N+L+ + R+L + L H +CKL R K S ++ G +
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLD 969
Score = 34.3 bits (77), Expect = 0.62
Identities = 20/61 (32%), Positives = 32/61 (52%)
Query: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
+T A + L SVL + L+ L+L N L + V L ++L P C+L+ + L GL
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 961 Q 961
+
Sbjct: 852 E 852
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 250 bits (638), Expect = 6e-66
Identities = 191/650 (29%), Positives = 309/650 (47%), Gaps = 41/650 (6%)
Query: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
Query: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
Query: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
Query: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
Query: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
Query: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
Query: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
Query: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
Query: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
Query: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
Query: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 111 bits (278), Expect = 3e-24
Identities = 59/154 (38%), Positives = 85/154 (55%)
Query: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900
+ N ++D G++LLC GLRHP C L+ +G M
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVM 962
Score = 109 bits (273), Expect = 1e-23
Identities = 64/168 (38%), Positives = 94/168 (55%)
Query: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +G P
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKP 959
Score = 92.4 bits (228), Expect = 2e-18
Identities = 59/164 (35%), Positives = 83/164 (50%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + ++ L L R+L L ++ S+S + L L P C + L L C L A
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
+C+++A L + +L +L LS N L G LC L P+C L L LV C LT +CC
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEEL 837
L VL SP+L++LDL N L + GV + L P C+L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 70.5 bits (171), Expect = 8e-12
Identities = 42/127 (33%), Positives = 63/127 (49%)
Query: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
Q + V+ L+ L++ N + + ++ LC LR P C+L + L C LT+ C+ L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
A L N+TL L+L N L + G L + L P C L+ + L GL + Q L +V
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 970 KERKPSL 976
PSL
Sbjct: 918 LSASPSL 924
Score = 34.7 bits (78), Expect = 0.48
Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKL-RTLKLSYVSTASGFE 679
+++ S+ SL+EL + N+L+ + R+L + L H +CKL R K S ++ G +
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLD 969
Score = 34.3 bits (77), Expect = 0.62
Identities = 20/61 (32%), Positives = 32/61 (52%)
Query: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
+T A + L SVL + L+ L+L N L + V L ++L P C+L+ + L GL
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 961 Q 961
+
Sbjct: 852 E 852
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 194 bits (493), Expect = 4e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
Score = 161 bits (407), Expect = 3e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
Query: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
Query: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
Score = 160 bits (404), Expect = 8e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
L + N L + GV +L + L P VL+V+ L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 142 bits (357), Expect = 2e-33
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
Query: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
Query: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
Score = 112 bits (281), Expect = 1e-24
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
Query: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
C L LKL + + R++C + + SLREL + N L +
Sbjct: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
Query: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 828 LFPTCQLEELHLSGCFFSSDI 848
P C LE+L L ++S ++
Sbjct: 423 RQPGCLLEQLVLYDIYWSEEM 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,517,094
Number of Sequences: 37866
Number of extensions: 1557559
Number of successful extensions: 5215
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 4533
Number of HSP's gapped (non-prelim): 271
length of query: 1033
length of database: 18,247,518
effective HSP length: 112
effective length of query: 921
effective length of database: 14,006,526
effective search space: 12900010446
effective search space used: 12900010446
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.