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Search of human proteins with 194018403
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
(327 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 657 0.0
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 640 0.0
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 205 4e-53
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 157 1e-38
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 96 4e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 91 1e-18
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 90 3e-18
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 89 5e-18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 89 5e-18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 89 5e-18
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 89 7e-18
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 88 9e-18
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 86 6e-17
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 85 8e-17
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 83 3e-16
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 82 8e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 80 2e-15
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 80 3e-15
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 79 4e-15
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 79 4e-15
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 79 4e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 79 4e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 79 4e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 79 4e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 79 4e-15
gi|8051593 GA binding protein transcription factor, beta subunit... 79 4e-15
gi|8051595 GA binding protein transcription factor, beta subunit... 79 4e-15
gi|32483404 GA binding protein transcription factor, beta subuni... 79 4e-15
gi|8051597 GA binding protein transcription factor, beta subunit... 79 4e-15
gi|8051599 GA binding protein transcription factor, beta subunit... 79 4e-15
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 657 bits (1695), Expect = 0.0
Identities = 327/327 (100%), Positives = 327/327 (100%)
Query: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG
Sbjct: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK
Sbjct: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
Query: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT
Sbjct: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
Query: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH 300
NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH
Sbjct: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH 300
Query: 301 PEPGAEHNGLEGPNDSGRETPQPVPAQ 327
PEPGAEHNGLEGPNDSGRETPQPVPAQ
Sbjct: 301 PEPGAEHNGLEGPNDSGRETPQPVPAQ 327
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 640 bits (1651), Expect = 0.0
Identities = 327/360 (90%), Positives = 327/360 (90%), Gaps = 33/360 (9%)
Query: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG
Sbjct: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK
Sbjct: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
Query: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT
Sbjct: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
Query: 241 NVRDK---------------------------------EGDTALHDAVRLNRYKIIKLLL 267
NVRDK EGDTALHDAVRLNRYKIIKLLL
Sbjct: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
Query: 268 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 327
LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
Sbjct: 301 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 360
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 205 bits (522), Expect = 4e-53
Identities = 106/237 (44%), Positives = 152/237 (64%), Gaps = 36/237 (15%)
Query: 92 QERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEET 151
+ ++K L+ R ++ ++ ++ +I+L+K++K +K PEPE IT PVD T
Sbjct: 67 EAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKE---PEPEIITEPVDVPT 123
Query: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
FLKAA+E K+ V+EKFL+D + D CD+++RTALHRA LEGH+ I+EKL++ GA ++F+D
Sbjct: 124 FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHG---------------------------------A 238
L+ TA+HWA RGG+L+V+KLL + G A
Sbjct: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
Query: 239 DTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTR 295
D N +D+EGDT LHDAVRLNRYK+I+LL+++GAD+ KN AGKTP DLV WQ T+
Sbjct: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 300
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 157 bits (397), Expect = 1e-38
Identities = 95/246 (38%), Positives = 130/246 (52%), Gaps = 37/246 (15%)
Query: 87 QKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGP 146
+K K ER T +L ++ ++NL++ RKKR + + P+ + P
Sbjct: 54 EKKKKLERFNSTRFNLD----NLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEP 109
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
V E FLKAA E + +I+K+L DGG + D+ RTALH A L+GH +++ KLL GAT
Sbjct: 110 VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVR----------------------- 243
VD +D LD T + WACRGGHL ++K L + GA N R
Sbjct: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
Query: 244 ----------DKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD 293
DKEGDTALH+AVR YK +KLLLL+GA++ +N A TP L + WQ
Sbjct: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRG 289
Query: 294 TRHALE 299
R AL+
Sbjct: 290 IREALQ 295
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 95.9 bits (237), Expect = 4e-20
Identities = 52/129 (40%), Positives = 71/129 (55%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +K E + + + D+ RTALH A+ GH E+++ LL GA ++ D+ D
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
A+HWA GH+EVVKLL SHGA+ +DK+ T LH A ++K LL G DM
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN 233
Query: 275 TKNLAGKTP 283
N G TP
Sbjct: 234 EPNAYGNTP 242
Score = 70.1 bits (170), Expect = 3e-12
Identities = 41/130 (31%), Positives = 67/130 (51%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+A + ++ L + D+ +T LH A+ ++ E L+ + V+ DR
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
TA+H A GH E+VKLL S GA+ N DK+ A+H A + +++KLL+ HGA++
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Query: 274 MTKNLAGKTP 283
K+ TP
Sbjct: 200 TCKDKKSYTP 209
Score = 69.7 bits (169), Expect = 3e-12
Identities = 42/129 (32%), Positives = 69/129 (53%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++++ L+ G + + D+ R A+H A+ GH+E+++ L+ +GA V +D+
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G + VVK L G D N + G+T LH A + ++ L+ GA +
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 275 TKNLAGKTP 283
KN G TP
Sbjct: 267 QKNEKGFTP 275
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/136 (31%), Positives = 66/136 (48%), Gaps = 4/136 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQF-RRTALHRASLEGHMEILEKLLDNGA---TVDFQ 210
AA +G ++ ++ + G S D +RT +H A+ GH E L L+ N VD Q
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
D T + + GH + V L + GA+ + +DK G TALH + + LL HG
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 271 ADMMTKNLAGKTPTDL 286
A + ++ G+TP L
Sbjct: 710 AKCLLRDSRGRTPIHL 725
Score = 62.8 bits (151), Expect = 4e-10
Identities = 42/136 (30%), Positives = 70/136 (51%), Gaps = 1/136 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++V++ ++ G D+ T LH A+ G + +++ LLD G ++ +
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKI-IKLLLLHGADM 273
T +H AC G VV L GA N ++++G T LH A + ++LL+ +GAD+
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
Query: 274 MTKNLAGKTPTDLVQL 289
K+ GKTP + L
Sbjct: 300 NMKSKDGKTPLHMTAL 315
Score = 62.0 bits (149), Expect = 7e-10
Identities = 37/99 (37%), Positives = 52/99 (52%)
Query: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
LH A+L G + KLL +G +D D T +H A GG+LE + LL + GAD N +D
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 245 KEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
K G + LH A Y+ + L+ GA + + G TP
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTP 474
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/135 (29%), Positives = 64/135 (47%)
Query: 148 DEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
D+ + ++A G + + + D +RT LH A+ G EI+E L+ +GA V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
+ +D T +H A E V++L H AD N RDK T LH A K + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 268 LHGADMMTKNLAGKT 282
+++ + AG+T
Sbjct: 128 PLLSNVNVSDRAGRT 142
Score = 60.5 bits (145), Expect = 2e-09
Identities = 35/100 (35%), Positives = 51/100 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G K L+ G DT D F RT LH A+ G++E L LL+ GA + +D+
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDA 254
+ +H+A + + + L GA N D+ G T LH A
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 60.5 bits (145), Expect = 2e-09
Identities = 48/168 (28%), Positives = 71/168 (42%), Gaps = 38/168 (22%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--- 210
+ AV G + ++ L G D RT +H ++ GH+ +L LL + A++D
Sbjct: 692 RGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAT 751
Query: 211 -DRLDCTAMHWACRGGHLEVVKLL-----------------------QSHGA-----DT- 240
D TA+HWAC GH V+LL + GA DT
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811
Query: 241 -----NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
N D +G T LH A + + ++LLL H A + + + GKTP
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP 859
Score = 58.2 bits (139), Expect = 1e-08
Identities = 42/142 (29%), Positives = 65/142 (45%), Gaps = 4/142 (2%)
Query: 130 LAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS 189
L + P +I + + + + G + L G + D D++ RTALHR +
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGA 694
Query: 190 LEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVV-KLLQSHG---ADTNVRDK 245
+ GH E ++ LL +GA +D T +H + GH+ V+ LLQS A+ D
Sbjct: 695 VTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754
Query: 246 EGDTALHDAVRLNRYKIIKLLL 267
G TALH A ++LLL
Sbjct: 755 HGYTALHWACYNGHETCVELLL 776
Score = 56.6 bits (135), Expect = 3e-08
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 3/122 (2%)
Query: 155 AAVEGKMKVIEKFLADG---GSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
AA G + + + + + D D +T L + L GH + + LL+ GA VD +D
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271
+ TA+H GH E V L HGA +RD G T +H + ++ LL A
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 272 DM 273
M
Sbjct: 744 SM 745
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/119 (31%), Positives = 59/119 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++IE + G + D T LHRA E ++ LL + A V+ +D+
Sbjct: 48 AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW 107
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
T +H A ++ + L ++ NV D+ G TALH A +++KLLL GA++
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/131 (28%), Positives = 61/131 (46%), Gaps = 1/131 (0%)
Query: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
F A+ G + +E + +G + + +T LH +L G + ++ +GA +D +D
Sbjct: 278 FAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271
+ T +H A R GH ++ L + GADT R G LH A + LL G
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 272 DMMTKNLAGKT 282
D+ T + G+T
Sbjct: 397 DIDTPDDFGRT 407
Score = 54.3 bits (129), Expect = 1e-07
Identities = 38/136 (27%), Positives = 60/136 (44%), Gaps = 1/136 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEI-LEKLLDNGATVDFQDRL 213
A G+ V+ + + G + ++ T LH A+ H + LE L+ NGA V+ + +
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
T +H G + + GA + DK G+T LH A R +I L+ GAD
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADT 365
Query: 274 MTKNLAGKTPTDLVQL 289
+ + G P L L
Sbjct: 366 AKRGIHGMFPLHLAAL 381
Score = 49.3 bits (116), Expect = 5e-06
Identities = 31/100 (31%), Positives = 51/100 (51%)
Query: 184 ALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVR 243
+L +A G + + L+ V+FQD T +H A G E+++LL GA N +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 244 DKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
D + T LH AV + +++LL H AD+ ++ +TP
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTP 110
Score = 44.7 bits (104), Expect = 1e-04
Identities = 35/133 (26%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNG-ATVDFQDRL 213
AA ++ ++ L+ ++ D +T L A+ G +E L+ + A + QD
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEG---DTALHDAVRLNRYKIIKLLLLHG 270
TA+H AC GH L+ D N+ + T LH A R +++ LL G
Sbjct: 890 KNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKG 949
Query: 271 ADMMTKNLAGKTP 283
A ++ + G TP
Sbjct: 950 ASVLAVDENGYTP 962
Score = 43.1 bits (100), Expect = 3e-04
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL-QSH 236
D RT LH A+ H+E L+ LL + A V+ D T + A G V++L S
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879
Query: 237 GADTNVRDKEGDTALH 252
A+ ++D +TALH
Sbjct: 880 SAELTLQDNSKNTALH 895
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/145 (24%), Positives = 65/145 (44%), Gaps = 13/145 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASL-EGHMEILEKLLDNGATVDFQDRL 213
AA + + + G S + D+ T LH A+ + + LE LL N A +D+
Sbjct: 445 AAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQ 504
Query: 214 DCTAMHWACRGGHLEVVKLLQSHG-----ADTNVRDKEGD-------TALHDAVRLNRYK 261
A+H++ GH ++L+ S +T+ D D + LH A ++
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ 564
Query: 262 IIKLLLLHGADMMTKNLAGKTPTDL 286
+++L+ D+ +N +G+TP DL
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDL 589
Score = 37.0 bits (84), Expect = 0.024
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 1/95 (1%)
Query: 174 ADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL 233
+D+ ++ + LH A+ GH + LE L+ + +D ++ T + A GH+E V +L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Query: 234 QSHGADTNVRDK-EGDTALHDAVRLNRYKIIKLLL 267
+ GA V+D T +H A + ++LL+
Sbjct: 603 INQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Score = 36.2 bits (82), Expect = 0.041
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 185 LHRASLEGHMEILEKLLDN--GATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
LH A + + E L+D + V+ D T +H A H+E ++LL SH A N
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
D G T L A + +++L+ + +T
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELT 884
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 90.9 bits (224), Expect = 1e-18
Identities = 50/128 (39%), Positives = 73/128 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +K E + S + D+ RTALH A+L GH+E++ LL GA ++ D+ D
Sbjct: 89 AAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD 148
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
A+HWA GHL+VV LL +HGA+ +DK+G T LH A + ++K LL G ++
Sbjct: 149 RRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID 208
Query: 275 TKNLAGKT 282
N+ G T
Sbjct: 209 EINVYGNT 216
Score = 72.4 bits (176), Expect = 5e-13
Identities = 44/128 (34%), Positives = 63/128 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +I G C LH A+L H + KLL +G +D D+
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A GG++E +KLLQS GAD + +DK G T LH A + I+ L+ GA++
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440
Query: 275 TKNLAGKT 282
+ G+T
Sbjct: 441 ETDDWGRT 448
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 73/129 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G ++++ LA G + + D+ R ALH A+ GH++++ L+++GA V +D+
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G + VVK L + G + + + G+TALH A + ++ L+ +GA++
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 275 TKNLAGKTP 283
N G TP
Sbjct: 242 QPNNNGFTP 250
Score = 67.0 bits (162), Expect = 2e-11
Identities = 38/130 (29%), Positives = 67/130 (51%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+A + ++ + + D+ +T LH A+ ++ E ++ ++V+ DR
Sbjct: 55 RAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRG 114
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
TA+H A GH+E+V LL + GA+ N DK+ ALH A + ++ LL+ HGA++
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV 174
Query: 274 MTKNLAGKTP 283
K+ G TP
Sbjct: 175 TCKDKKGYTP 184
Score = 62.8 bits (151), Expect = 4e-10
Identities = 35/100 (35%), Positives = 52/100 (52%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ K L+ G DT D+F RT LH A+ G++E ++ L +GA +D+
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDA 254
T +H+A H ++ L + GA+ N D G TALH A
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 61.2 bits (147), Expect = 1e-09
Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 1/142 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V+ + G D+ T LH A+ G + +++ LL+ G +D +
Sbjct: 155 AAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKI-IKLLLLHGADM 273
TA+H AC G VV L +GA+ N + G T LH A + ++LL+ +GAD+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 274 MTKNLAGKTPTDLVQLWQADTR 295
++ GK+P + + TR
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTR 296
Score = 61.2 bits (147), Expect = 1e-09
Identities = 40/128 (31%), Positives = 57/128 (44%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
AV G+ + + +GG D D+ T LH A+ GH ++ L +GA
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM 348
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+H A H + + L S G + + DK G T LH A + IKLL GAD
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 276 KNLAGKTP 283
K+ G+TP
Sbjct: 409 KDKCGRTP 416
Score = 60.8 bits (146), Expect = 2e-09
Identities = 36/108 (33%), Positives = 56/108 (51%)
Query: 175 DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
+T D +RT LH A+ G EI+E L+ +GA V+ +D + T +H A E V++L
Sbjct: 10 NTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLI 69
Query: 235 SHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
H AD N RDK T LH A K ++++ + + + G+T
Sbjct: 70 KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRT 117
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/133 (29%), Positives = 65/133 (48%), Gaps = 4/133 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQF-RRTALHRASLEGH---MEILEKLLDNGATVDFQ 210
AA +G + +E + G S D +RT LH + + GH + +L ++ DN VD +
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
D T + A GH++ V LL A+ + D G TALH + + +++LL
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 271 ADMMTKNLAGKTP 283
++ K+ G+TP
Sbjct: 702 VSILCKDSRGRTP 714
Score = 54.3 bits (129), Expect = 1e-07
Identities = 44/169 (26%), Positives = 69/169 (40%), Gaps = 34/169 (20%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G++ V++ L G D + + TALH A G ++ +L+D GA V+ +
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 215 CTAMHWACRGGHLEV-VKLLQSHGADTNVR------------------------------ 243
T +H+A H + ++LL ++GAD N++
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 244 ---DKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQL 289
DK+G+T LH A R +I L GAD + P L L
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Score = 51.6 bits (122), Expect = 9e-07
Identities = 36/134 (26%), Positives = 60/134 (44%), Gaps = 5/134 (3%)
Query: 138 PEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEIL 197
PE ++ + + A G + + L + DT D TALHR + GH E +
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHL----EVVKLLQSHGADTNVRDKEGDTALHD 253
+ LL+ ++ +D T +H+A GH E++++ S D +D +G T LH
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE-EDCCFKDNQGYTPLHW 753
Query: 254 AVRLNRYKIIKLLL 267
A I++LL
Sbjct: 754 ACYNGNENCIEVLL 767
Score = 50.4 bits (119), Expect = 2e-06
Identities = 40/120 (33%), Positives = 52/120 (43%), Gaps = 4/120 (3%)
Query: 168 LADGGSA-DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGH 226
+AD A D D +T L A GH++ + LL+ A VD D L CTA+H GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 227 LEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL---LHGADMMTKNLAGKTP 283
E V++L +D G T LH A + LL L D K+ G TP
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Score = 49.7 bits (117), Expect = 4e-06
Identities = 43/136 (31%), Positives = 66/136 (48%), Gaps = 8/136 (5%)
Query: 155 AAVEGKMKVIEKFL--ADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
AA G + +E L + G ++ ++ LH A+ GH + LE LL + +D +D
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDK-EGDTALHDAVRLNRYKIIKLLLLHGA 271
TA+ A GH E V+ L + GA V+D T LH +V +N + + LLL A
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASV-INGHTLCLRLLLEIA 632
Query: 272 D----MMTKNLAGKTP 283
D + K+ G+TP
Sbjct: 633 DNPEAVDVKDAKGQTP 648
Score = 45.1 bits (105), Expect = 9e-05
Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 28/160 (17%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++ I+ + G D+ RT LH A+ H +E L+ GA V+ D
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 446
Query: 215 CTAMHWAC----------------------RGGHLE------VVKLLQSHGADTNVRDKE 246
TA+H+A R L+ ++ L + A+ ++RDKE
Sbjct: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKE 506
Query: 247 GDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 286
G ++H A + ++LLL ++ +G T + L
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPL 546
Score = 43.9 bits (102), Expect = 2e-04
Identities = 32/91 (35%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL-QSH 236
D RT L A+ H+E L+ LL + A V+ D TA+ A G V +L S
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 237 GADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
AD V+DK+ +T LH A K L+L
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Score = 40.8 bits (94), Expect = 0.002
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 3/78 (3%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKL 265
T+D + R T +H A G E+++LL GA N +D T LH AV + +++
Sbjct: 11 TLDSEKR---TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 266 LLLHGADMMTKNLAGKTP 283
L+ H AD+ ++ +TP
Sbjct: 68 LIKHSADVNARDKNWQTP 85
Score = 36.2 bits (82), Expect = 0.041
Identities = 31/107 (28%), Positives = 45/107 (42%), Gaps = 3/107 (2%)
Query: 183 TALHRASLEGHMEILEKLLD--NGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
T LH A + H LL + + V +D T + A H+E ++LL H A
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHG-ADMMTKNLAGKTPTDL 286
N D G TAL A + + +L+ AD+ K+ TP L
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887
Score = 33.5 bits (75), Expect = 0.26
Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 5/88 (5%)
Query: 239 DTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHAL 298
D N D E T LH A L +II+LL+L GA + K+ TP L +A +
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTP-----LHRAVASRSE 62
Query: 299 EHPEPGAEHNGLEGPNDSGRETPQPVPA 326
E + +H+ D +TP V A
Sbjct: 63 EAVQVLIKHSADVNARDKNWQTPLHVAA 90
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 89.7 bits (221), Expect = 3e-18
Identities = 48/134 (35%), Positives = 75/134 (55%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +I L G +A + + LH A +GH ++++ LLD+ A + +D
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + +AC GGH E+V LL HGA N + +G+TALH+AV +++LLLLHGA +
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
Query: 275 TKNLAGKTPTDLVQ 288
N +T D +
Sbjct: 871 VLNKRQRTAVDCAE 884
Score = 65.5 bits (158), Expect = 6e-11
Identities = 41/132 (31%), Positives = 67/132 (50%), Gaps = 3/132 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AAV G+ +I+ ++ G + D T LH A +G+ + LL A+ + QD
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADT---NVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271
T +H AC GH + VK L + ++ ++ +++GDT LH A R +I+ LL +GA
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 272 DMMTKNLAGKTP 283
+N +TP
Sbjct: 590 STEIQNRLKETP 601
Score = 55.5 bits (132), Expect = 7e-08
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 3/116 (2%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHG 237
D T LH A++ G +++ L+ GA V+ D T +H AC+ G+ V LL +
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
Query: 238 ADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD---MMTKNLAGKTPTDLVQLW 290
A V+D G+T LH A +K L+ + + + N G TP + W
Sbjct: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
Score = 44.7 bits (104), Expect = 1e-04
Identities = 25/87 (28%), Positives = 44/87 (50%)
Query: 197 LEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVR 256
L K+ +G V+ + + +H A G +++ LL HGA+ R+ + LH A +
Sbjct: 727 LAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQ 786
Query: 257 LNRYKIIKLLLLHGADMMTKNLAGKTP 283
++++K LL A K+L+G TP
Sbjct: 787 QGHFQVVKCLLDSNAKPNKKDLSGNTP 813
Score = 37.0 bits (84), Expect = 0.024
Identities = 51/208 (24%), Positives = 79/208 (37%), Gaps = 31/208 (14%)
Query: 92 QERVRKTSLD--LRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDE 149
Q R+++T L L +I+ V L +R+QK +A P P+ + +
Sbjct: 594 QNRLKETPLKCALNSKILSV---MEAYHLSFERRQKSSEA------PVQSPQRSVDSISQ 644
Query: 150 ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTA-LHRASLEGHMEILEKLL------- 201
E+ + A +T +R L RA +G +E++ LL
Sbjct: 645 ESSTSS--------FSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDL 696
Query: 202 -DNGATVDFQDRLDCTAMHWA--CRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLN 258
D TV D C + C + K+ S G NV ++G + LH A
Sbjct: 697 EDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPAS-GLGVNVTSQDGSSPLHVAALHG 755
Query: 259 RYKIIKLLLLHGADMMTKNLAGKTPTDL 286
R +I LLL HGA+ +N P L
Sbjct: 756 RADLIPLLLKHGANAGARNADQAVPLHL 783
Score = 33.9 bits (76), Expect = 0.20
Identities = 18/49 (36%), Positives = 28/49 (57%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVK 231
T LH A+ G+ ++E LL NGA+ + Q+RL T + A L V++
Sbjct: 567 TPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 89.0 bits (219), Expect = 5e-18
Identities = 49/133 (36%), Positives = 77/133 (57%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVVK+L GA+ N + + G T L+ A + N ++K LL +G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 271 ADMMTKNLAGKTP 283
A+ T G TP
Sbjct: 133 ANQSTATEDGFTP 145
Score = 79.0 bits (193), Expect = 5e-15
Identities = 54/155 (34%), Positives = 79/155 (50%), Gaps = 3/155 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A R G +EVV+ L +GA + R +E T LH A RL + +I++LLL H A
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 275 TKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 308
G TP + + Q D L E GA H+
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 536
Score = 70.1 bits (170), Expect = 3e-12
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R G E+V+LL H A + G T LH + R + + +LL GA
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 537 LATKKGFTP 545
Score = 70.1 bits (170), Expect = 3e-12
Identities = 41/129 (31%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T++H A + + V +L HGAD + K G T L A K++ LL GA++
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734
Query: 275 TKNLAGKTP 283
K G TP
Sbjct: 735 AKTKNGYTP 743
Score = 69.3 bits (168), Expect = 4e-12
Identities = 41/125 (32%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD----TRHAL 298
+ ++G T LH A R ++++LLL GA ++ + G +P + Q D +H L
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA--QGDHVECVKHLL 331
Query: 299 EHPEP 303
+H P
Sbjct: 332 QHKAP 336
Score = 67.4 bits (163), Expect = 2e-11
Identities = 36/113 (31%), Positives = 65/113 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + ++++ L G S D+ + TALH ASL G E+++ L+ GA ++ Q +
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
T ++ A + H++VVK L +GA+ + ++G T L A++ + + +LL
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 66.6 bits (161), Expect = 3e-11
Identities = 42/129 (32%), Positives = 65/129 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G +++ L GG D + T LH A+ GH +++E LL+ GA + + +
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G H+E VK L H A + + TALH A Y++ KLLL A+
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371
Query: 275 TKNLAGKTP 283
+ L G TP
Sbjct: 372 ARALNGFTP 380
Score = 66.6 bits (161), Expect = 3e-11
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V+E L G + + LH A+ H+E ++ LL + A VD
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 344
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A GH V KLL A+ N R G T LH A + NR K+++LL+ +GA +
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404
Query: 275 TKNLAGKTP 283
+G TP
Sbjct: 405 AITESGLTP 413
Score = 65.9 bits (159), Expect = 5e-11
Identities = 48/146 (32%), Positives = 65/146 (44%), Gaps = 11/146 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VV+LL GA R K G + LH A + + + +K LL H
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH----- 333
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEH 300
K P D V L H H
Sbjct: 334 ------KAPVDDVTLDYLTALHVAAH 353
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/129 (31%), Positives = 61/129 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA KV L G S + T LH A+ + M+I LL+ GA + +
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 641
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++V LL GA+ ++ K G T+LH A + ++ + +L HGAD
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 702 AHTKLGYTP 710
Score = 63.5 bits (153), Expect = 2e-10
Identities = 39/128 (30%), Positives = 60/128 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + AC G++++V L GA+ N + K G T LH A + II +LL HGA
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 275 TKNLAGKT 282
G T
Sbjct: 768 ATTANGNT 775
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 14/146 (9%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP---------TDLVQLWQAD 293
+ G+TALH A R + ++++ LL +GA + + +TP T++VQL
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL---- 494
Query: 294 TRHALEHPEPGAEHNGLEGPNDSGRE 319
+ HP+ A NG + S RE
Sbjct: 495 LLQHMAHPD-AATTNGYTPLHISARE 519
Score = 57.8 bits (138), Expect = 1e-08
Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G L+V KLL A + K G T LH A + K+ LL
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 267 LLHGADMMTKNLAGKTP 283
L GA G TP
Sbjct: 595 LEKGASPHATAKNGYTP 611
Score = 56.6 bits (135), Expect = 3e-08
Identities = 33/100 (33%), Positives = 52/100 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
+ G T +H A + I+ LLL +GA N+ G+T
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
Score = 55.5 bits (132), Expect = 7e-08
Identities = 39/132 (29%), Positives = 59/132 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +V LL GA + K G T LH A + N+ +I LL +GA+
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635
Query: 275 TKNLAGKTPTDL 286
G TP L
Sbjct: 636 IVTKQGVTPLHL 647
Score = 55.5 bits (132), Expect = 7e-08
Identities = 37/132 (28%), Positives = 65/132 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +++ L ++GA+TN+ K+G T LH A + ++ LLL GA++
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 275 TKNLAGKTPTDL 286
+G T L
Sbjct: 669 MSTKSGLTSLHL 680
Score = 55.1 bits (131), Expect = 9e-08
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E K+ V + G D + T L A G+++++ LL GA V+ + +
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 740
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++ +L HGA N G+TAL A RL ++ L + ++
Sbjct: 741 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 800
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEHPEPGAE 306
T T T + + +H L PE E
Sbjct: 801 T------TTTTITE------KHKLNVPETMTE 820
Score = 51.2 bits (121), Expect = 1e-06
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 6/130 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 83 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLL--HGAD 272
T + A + GH + V +L + + + K ALH A R + K LLL H AD
Sbjct: 143 FTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 198
Query: 273 MMTKNLAGKT 282
+ +K + +T
Sbjct: 199 VQSKMMVNRT 208
Score = 40.8 bits (94), Expect = 0.002
Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 12/137 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E + V++ L +G + T + T L A +GH + + LL+N D + ++
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVR 171
Query: 215 CTAMHWACRGGHLEVVKLL--QSHGADT------NVRDKEGDTALHDAVRLNRYKIIKLL 266
A+H A R + LL H AD N + G T LH A + LL
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
Query: 267 LLHGADMMTKNLAGKTP 283
L GA + G TP
Sbjct: 232 LNRGAAVDFTARNGITP 248
Score = 30.0 bits (66), Expect = 2.9
Identities = 19/69 (27%), Positives = 31/69 (44%)
Query: 221 ACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 280
A R G+L+ V G D N ++ G ALH A + +++ LL G+ + + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 281 KTPTDLVQL 289
T + L
Sbjct: 77 NTALHIASL 85
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 89.0 bits (219), Expect = 5e-18
Identities = 49/133 (36%), Positives = 77/133 (57%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVVK+L GA+ N + + G T L+ A + N ++K LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 271 ADMMTKNLAGKTP 283
A+ T G TP
Sbjct: 154 ANQSTATEDGFTP 166
Score = 79.0 bits (193), Expect = 5e-15
Identities = 54/155 (34%), Positives = 79/155 (50%), Gaps = 3/155 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A R G +EVV+ L +GA + R +E T LH A RL + +I++LLL H A
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 275 TKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 308
G TP + + Q D L E GA H+
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 557
Score = 70.1 bits (170), Expect = 3e-12
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R G E+V+LL H A + G T LH + R + + +LL GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 558 LATKKGFTP 566
Score = 70.1 bits (170), Expect = 3e-12
Identities = 41/129 (31%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T++H A + + V +L HGAD + K G T L A K++ LL GA++
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 275 TKNLAGKTP 283
K G TP
Sbjct: 756 AKTKNGYTP 764
Score = 69.3 bits (168), Expect = 4e-12
Identities = 41/125 (32%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD----TRHAL 298
+ ++G T LH A R ++++LLL GA ++ + G +P + Q D +H L
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA--QGDHVECVKHLL 352
Query: 299 EHPEP 303
+H P
Sbjct: 353 QHKAP 357
Score = 67.4 bits (163), Expect = 2e-11
Identities = 36/113 (31%), Positives = 65/113 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + ++++ L G S D+ + TALH ASL G E+++ L+ GA ++ Q +
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
T ++ A + H++VVK L +GA+ + ++G T L A++ + + +LL
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 66.6 bits (161), Expect = 3e-11
Identities = 42/129 (32%), Positives = 65/129 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G +++ L GG D + T LH A+ GH +++E LL+ GA + + +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G H+E VK L H A + + TALH A Y++ KLLL A+
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 275 TKNLAGKTP 283
+ L G TP
Sbjct: 393 ARALNGFTP 401
Score = 66.6 bits (161), Expect = 3e-11
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V+E L G + + LH A+ H+E ++ LL + A VD
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A GH V KLL A+ N R G T LH A + NR K+++LL+ +GA +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 275 TKNLAGKTP 283
+G TP
Sbjct: 426 AITESGLTP 434
Score = 65.9 bits (159), Expect = 5e-11
Identities = 48/146 (32%), Positives = 65/146 (44%), Gaps = 11/146 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VV+LL GA R K G + LH A + + + +K LL H
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH----- 354
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEH 300
K P D V L H H
Sbjct: 355 ------KAPVDDVTLDYLTALHVAAH 374
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/129 (31%), Positives = 61/129 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA KV L G S + T LH A+ + M+I LL+ GA + +
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++V LL GA+ ++ K G T+LH A + ++ + +L HGAD
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 723 AHTKLGYTP 731
Score = 63.5 bits (153), Expect = 2e-10
Identities = 39/128 (30%), Positives = 60/128 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + AC G++++V L GA+ N + K G T LH A + II +LL HGA
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 275 TKNLAGKT 282
G T
Sbjct: 789 ATTANGNT 796
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 14/146 (9%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP---------TDLVQLWQAD 293
+ G+TALH A R + ++++ LL +GA + + +TP T++VQL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL---- 515
Query: 294 TRHALEHPEPGAEHNGLEGPNDSGRE 319
+ HP+ A NG + S RE
Sbjct: 516 LLQHMAHPD-AATTNGYTPLHISARE 540
Score = 57.8 bits (138), Expect = 1e-08
Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G L+V KLL A + K G T LH A + K+ LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 267 LLHGADMMTKNLAGKTP 283
L GA G TP
Sbjct: 616 LEKGASPHATAKNGYTP 632
Score = 56.6 bits (135), Expect = 3e-08
Identities = 33/100 (33%), Positives = 52/100 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
+ G T +H A + I+ LLL +GA N+ G+T
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Score = 55.5 bits (132), Expect = 7e-08
Identities = 39/132 (29%), Positives = 59/132 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +V LL GA + K G T LH A + N+ +I LL +GA+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 275 TKNLAGKTPTDL 286
G TP L
Sbjct: 657 IVTKQGVTPLHL 668
Score = 55.5 bits (132), Expect = 7e-08
Identities = 37/132 (28%), Positives = 65/132 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +++ L ++GA+TN+ K+G T LH A + ++ LLL GA++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 275 TKNLAGKTPTDL 286
+G T L
Sbjct: 690 MSTKSGLTSLHL 701
Score = 55.1 bits (131), Expect = 9e-08
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E K+ V + G D + T L A G+++++ LL GA V+ + +
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++ +L HGA N G+TAL A RL ++ L + ++
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEHPEPGAE 306
T T T + + +H L PE E
Sbjct: 822 T------TTTTITE------KHKLNVPETMTE 841
Score = 51.2 bits (121), Expect = 1e-06
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 6/130 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLL--HGAD 272
T + A + GH + V +L + + + K ALH A R + K LLL H AD
Sbjct: 164 FTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219
Query: 273 MMTKNLAGKT 282
+ +K + +T
Sbjct: 220 VQSKMMVNRT 229
Score = 40.8 bits (94), Expect = 0.002
Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 12/137 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E + V++ L +G + T + T L A +GH + + LL+N D + ++
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVR 192
Query: 215 CTAMHWACRGGHLEVVKLL--QSHGADT------NVRDKEGDTALHDAVRLNRYKIIKLL 266
A+H A R + LL H AD N + G T LH A + LL
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 267 LLHGADMMTKNLAGKTP 283
L GA + G TP
Sbjct: 253 LNRGAAVDFTARNGITP 269
Score = 30.0 bits (66), Expect = 2.9
Identities = 19/69 (27%), Positives = 31/69 (44%)
Query: 221 ACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 280
A R G+L+ V G D N ++ G ALH A + +++ LL G+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 281 KTPTDLVQL 289
T + L
Sbjct: 98 NTALHIASL 106
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 89.0 bits (219), Expect = 5e-18
Identities = 49/133 (36%), Positives = 77/133 (57%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVVK+L GA+ N + + G T L+ A + N ++K LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 271 ADMMTKNLAGKTP 283
A+ T G TP
Sbjct: 154 ANQSTATEDGFTP 166
Score = 79.0 bits (193), Expect = 5e-15
Identities = 54/155 (34%), Positives = 79/155 (50%), Gaps = 3/155 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A R G +EVV+ L +GA + R +E T LH A RL + +I++LLL H A
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 275 TKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 308
G TP + + Q D L E GA H+
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 557
Score = 70.1 bits (170), Expect = 3e-12
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R G E+V+LL H A + G T LH + R + + +LL GA
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 558 LATKKGFTP 566
Score = 70.1 bits (170), Expect = 3e-12
Identities = 41/129 (31%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T++H A + + V +L HGAD + K G T L A K++ LL GA++
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 275 TKNLAGKTP 283
K G TP
Sbjct: 756 AKTKNGYTP 764
Score = 69.3 bits (168), Expect = 4e-12
Identities = 41/125 (32%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD----TRHAL 298
+ ++G T LH A R ++++LLL GA ++ + G +P + Q D +H L
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA--QGDHVECVKHLL 352
Query: 299 EHPEP 303
+H P
Sbjct: 353 QHKAP 357
Score = 67.4 bits (163), Expect = 2e-11
Identities = 36/113 (31%), Positives = 65/113 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + ++++ L G S D+ + TALH ASL G E+++ L+ GA ++ Q +
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
T ++ A + H++VVK L +GA+ + ++G T L A++ + + +LL
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 66.6 bits (161), Expect = 3e-11
Identities = 42/129 (32%), Positives = 65/129 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G +++ L GG D + T LH A+ GH +++E LL+ GA + + +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G H+E VK L H A + + TALH A Y++ KLLL A+
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392
Query: 275 TKNLAGKTP 283
+ L G TP
Sbjct: 393 ARALNGFTP 401
Score = 66.6 bits (161), Expect = 3e-11
Identities = 45/129 (34%), Positives = 64/129 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V+E L G + + LH A+ H+E ++ LL + A VD
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A GH V KLL A+ N R G T LH A + NR K+++LL+ +GA +
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 275 TKNLAGKTP 283
+G TP
Sbjct: 426 AITESGLTP 434
Score = 65.9 bits (159), Expect = 5e-11
Identities = 48/146 (32%), Positives = 65/146 (44%), Gaps = 11/146 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VV+LL GA R K G + LH A + + + +K LL H
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH----- 354
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEH 300
K P D V L H H
Sbjct: 355 ------KAPVDDVTLDYLTALHVAAH 374
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/129 (31%), Positives = 61/129 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA KV L G S + T LH A+ + M+I LL+ GA + +
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG 662
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++V LL GA+ ++ K G T+LH A + ++ + +L HGAD
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 723 AHTKLGYTP 731
Score = 63.5 bits (153), Expect = 2e-10
Identities = 39/128 (30%), Positives = 60/128 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + AC G++++V L GA+ N + K G T LH A + II +LL HGA
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 275 TKNLAGKT 282
G T
Sbjct: 789 ATTANGNT 796
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 14/146 (9%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP---------TDLVQLWQAD 293
+ G+TALH A R + ++++ LL +GA + + +TP T++VQL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL---- 515
Query: 294 TRHALEHPEPGAEHNGLEGPNDSGRE 319
+ HP+ A NG + S RE
Sbjct: 516 LLQHMAHPD-AATTNGYTPLHISARE 540
Score = 57.8 bits (138), Expect = 1e-08
Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G L+V KLL A + K G T LH A + K+ LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 267 LLHGADMMTKNLAGKTP 283
L GA G TP
Sbjct: 616 LEKGASPHATAKNGYTP 632
Score = 56.6 bits (135), Expect = 3e-08
Identities = 33/100 (33%), Positives = 52/100 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
+ G T +H A + I+ LLL +GA N+ G+T
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Score = 55.5 bits (132), Expect = 7e-08
Identities = 39/132 (29%), Positives = 59/132 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +V LL GA + K G T LH A + N+ +I LL +GA+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 275 TKNLAGKTPTDL 286
G TP L
Sbjct: 657 IVTKQGVTPLHL 668
Score = 55.5 bits (132), Expect = 7e-08
Identities = 37/132 (28%), Positives = 65/132 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +++ L ++GA+TN+ K+G T LH A + ++ LLL GA++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 275 TKNLAGKTPTDL 286
+G T L
Sbjct: 690 MSTKSGLTSLHL 701
Score = 55.1 bits (131), Expect = 9e-08
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E K+ V + G D + T L A G+++++ LL GA V+ + +
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNG 761
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++ +L HGA N G+TAL A RL ++ L + ++
Sbjct: 762 YTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVT 821
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEHPEPGAE 306
T T T + + +H L PE E
Sbjct: 822 T------TTTTITE------KHKLNVPETMTE 841
Score = 51.2 bits (121), Expect = 1e-06
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 6/130 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLL--HGAD 272
T + A + GH + V +L + + + K ALH A R + K LLL H AD
Sbjct: 164 FTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219
Query: 273 MMTKNLAGKT 282
+ +K + +T
Sbjct: 220 VQSKMMVNRT 229
Score = 40.8 bits (94), Expect = 0.002
Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 12/137 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E + V++ L +G + T + T L A +GH + + LL+N D + ++
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVR 192
Query: 215 CTAMHWACRGGHLEVVKLL--QSHGADT------NVRDKEGDTALHDAVRLNRYKIIKLL 266
A+H A R + LL H AD N + G T LH A + LL
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 267 LLHGADMMTKNLAGKTP 283
L GA + G TP
Sbjct: 253 LNRGAAVDFTARNGITP 269
Score = 30.0 bits (66), Expect = 2.9
Identities = 19/69 (27%), Positives = 31/69 (44%)
Query: 221 ACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 280
A R G+L+ V G D N ++ G ALH A + +++ LL G+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 281 KTPTDLVQL 289
T + L
Sbjct: 98 NTALHIASL 106
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 88.6 bits (218), Expect = 7e-18
Identities = 55/151 (36%), Positives = 78/151 (51%), Gaps = 1/151 (0%)
Query: 149 EETFLKAAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
+ L+AA G ++ ++K + + + T LH A+ + ++E LL +GA V
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
+D+ +H AC GH EV +LL HGA NV D T LH+A +Y+I KLLL
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 268 LHGADMMTKNLAGKTPTDLVQLWQADTRHAL 298
HGAD KN G TP DLV+ D + L
Sbjct: 613 QHGADPTKKNRDGNTPLDLVKDGDTDIQDLL 643
Score = 80.9 bits (198), Expect = 1e-15
Identities = 53/147 (36%), Positives = 75/147 (51%), Gaps = 4/147 (2%)
Query: 142 EITGPVDEETFLKAAVEGKMKVIEKFLADG--GSADTCDQFRRTALHRASLEGHMEILEK 199
E P E F +A G ++ +++ + S DT + + T LH A+ G +++E
Sbjct: 19 EAVEPAARELF-EACRNGDVERVKRLVTPEKVNSRDTAGR-KSTPLHFAAGFGRKDVVEY 76
Query: 200 LLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNR 259
LL NGA V +D +H AC GH EVV LL HGAD N RD T LH+A +
Sbjct: 77 LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGK 136
Query: 260 YKIIKLLLLHGADMMTKNLAGKTPTDL 286
+ +LL HGA+ +N G+T DL
Sbjct: 137 IDVCIVLLQHGAEPTIRNTDGRTALDL 163
Score = 79.7 bits (195), Expect = 3e-15
Identities = 54/164 (32%), Positives = 78/164 (47%), Gaps = 1/164 (0%)
Query: 137 PPEPEEITGPVDEETFLKAAVEGKMKVIEKFLAD-GGSADTCDQFRRTALHRASLEGHME 195
P +TG ++ L++A G + + L + D + T LH A+ ++
Sbjct: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225
Query: 196 ILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAV 255
I++ LL +GA V +D+ D +H AC GH EV +LL HGA N D T LH+A
Sbjct: 226 IVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285
Query: 256 RLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALE 299
NR ++ LLL +GAD N K+ DL Q R A E
Sbjct: 286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYE 329
Score = 79.3 bits (194), Expect = 4e-15
Identities = 50/140 (35%), Positives = 73/140 (52%), Gaps = 1/140 (0%)
Query: 149 EETFLKAAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
+ L AA +G + ++K + D + T LH A+ ++E+ E LL +GA V
Sbjct: 646 DAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADV 705
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
+ QD+ +H A GH++V LL + A N DK T LH+A + R ++ LLL
Sbjct: 706 NAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLL 765
Query: 268 LHGADMMTKNLAGKTPTDLV 287
HGAD KN G+TP DLV
Sbjct: 766 AHGADPTLKNQEGQTPLDLV 785
Score = 56.6 bits (135), Expect = 3e-08
Identities = 48/183 (26%), Positives = 65/183 (35%), Gaps = 54/183 (29%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA ++ V+E L G D+ LH A GH E+ E L+ +GA V+ D
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592
Query: 215 CTAMHWACRGGHLEVVKLLQSHGAD----------------------------------- 239
T +H A G E+ KLL HGAD
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652
Query: 240 -----------------TNVRDKEG--DTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 280
N RD +G T LH A N ++ + LL HGAD+ ++ G
Sbjct: 653 AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGG 712
Query: 281 KTP 283
P
Sbjct: 713 LIP 715
Score = 55.1 bits (131), Expect = 9e-08
Identities = 44/149 (29%), Positives = 67/149 (44%), Gaps = 3/149 (2%)
Query: 137 PPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH--- 193
P E + + L+AA E + I+K L+ Q TALH A+ +
Sbjct: 320 PQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKR 379
Query: 194 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHD 253
+I E LL GA ++ + + T +H A H +VV+++ H A N D G T+LH
Sbjct: 380 KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHR 439
Query: 254 AVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
A + +LLL +G D +L G T
Sbjct: 440 AAYCGHLQTCRLLLSYGCDPNIISLQGFT 468
Score = 54.3 bits (129), Expect = 1e-07
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 146 PVDEETFLKAAVEG----KMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL 201
P ET L A + ++ E L G + + + T LH AS + H +++E ++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420
Query: 202 DNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTAL 251
+ A V+ D L T++H A GHL+ +LL S+G D N+ +G TAL
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
Score = 53.5 bits (127), Expect = 2e-07
Identities = 50/184 (27%), Positives = 76/184 (41%), Gaps = 26/184 (14%)
Query: 159 GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAM 218
G +V+ L G + D + T LH A+++G +++ LL +GA ++ TA+
Sbjct: 102 GHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTAL 161
Query: 219 HWA--------------------CRGGHLE-VVKLLQSHGADTNVRDKEGDTALHDAVRL 257
A R G+ E ++ LL + + D T LH A
Sbjct: 162 DLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGY 221
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSG 317
NR KI++LLL HGAD+ K+ DLV L A + E E +H D
Sbjct: 222 NRVKIVQLLLQHGADVHAKDKG-----DLVPLHNACSYGHYEVTELLVKHGACVNAMDLW 276
Query: 318 RETP 321
+ TP
Sbjct: 277 QFTP 280
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 88.2 bits (217), Expect = 9e-18
Identities = 71/235 (30%), Positives = 111/235 (47%), Gaps = 14/235 (5%)
Query: 72 VLEDEKHHGAQSAALQKVKGQERVRKTSL----DLRREIIDVGGIQNLIELRK-KRKQKK 126
V+E HGA+ AL + GQ + + +L R ++ G ++I L+ Q
Sbjct: 573 VMEVLHKHGAKMNALDTL-GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG 631
Query: 127 RDALAA--SHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGG-SADTCDQFRRT 183
+A+ S P ++ + L+A+ G ++ +++ + + + T
Sbjct: 632 NEAVQQILSESTPIRTSDV-----DYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHST 686
Query: 184 ALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVR 243
LH A+ + ++E LL +GA V +D+ +H AC GH EV +LL HGA NV
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746
Query: 244 DKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHAL 298
D T LH+A +Y+I KLLL HGAD KN G TP DLV+ D + L
Sbjct: 747 DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL 801
Score = 80.1 bits (196), Expect = 2e-15
Identities = 51/151 (33%), Positives = 73/151 (48%), Gaps = 1/151 (0%)
Query: 137 PPEPEEITGPVDEETFLKAAVEGKMKVIEKFLAD-GGSADTCDQFRRTALHRASLEGHME 195
P +TG ++ L+AA G + + L + D + T LH A+ +
Sbjct: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVR 383
Query: 196 ILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAV 255
I++ LL +GA V +D+ +H AC GH EV +LL HGA N D T LH+A
Sbjct: 384 IVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA 443
Query: 256 RLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 286
NR ++ LLL HGAD N GK+ D+
Sbjct: 444 SKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474
Score = 76.3 bits (186), Expect = 4e-14
Identities = 48/139 (34%), Positives = 71/139 (51%), Gaps = 1/139 (0%)
Query: 149 EETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEILEKLLDNGATV 207
+ L AA +G + ++K Q R T LH A+ ++E+ E LL++GA V
Sbjct: 804 DAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADV 863
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
+ QD+ +H A GH+++ LL + N DK T LH+A + R ++ LLL
Sbjct: 864 NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLL 923
Query: 268 LHGADMMTKNLAGKTPTDL 286
HGAD KN G+TP DL
Sbjct: 924 AHGADPTMKNQEGQTPLDL 942
Score = 74.3 bits (181), Expect = 1e-13
Identities = 49/136 (36%), Positives = 69/136 (50%), Gaps = 3/136 (2%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTA--LHRASLEGHMEILEKLLDNGATVDFQ 210
L+A G + +++ L D + + D R + LH A+ G +++E LL GA V +
Sbjct: 187 LEACRNGDVSRVKR-LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
D +H AC GH EVV LL GAD N RD T LH+A + + +LL HG
Sbjct: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Query: 271 ADMMTKNLAGKTPTDL 286
AD +N GK+ DL
Sbjct: 306 ADPNIRNTDGKSALDL 321
Score = 65.5 bits (158), Expect = 6e-11
Identities = 51/160 (31%), Positives = 74/160 (46%), Gaps = 4/160 (2%)
Query: 131 AASHEPPPE-PEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS 189
A P PE E +T + L+AA E + ++K LA Q TALH A
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 190 LEGH---MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKE 246
H ++ E LL GA V+ +++ T +H A H +V+++L HGA N D
Sbjct: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
Query: 247 GDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 286
G TALH A + +LLL +G+D +L G T +
Sbjct: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM 630
Score = 56.2 bits (134), Expect = 4e-08
Identities = 47/183 (25%), Positives = 68/183 (37%), Gaps = 54/183 (29%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA ++ V+E L G D+ LH A GH E+ E L+ +GA+V+ D
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRD----------KEGDTALHDAVR-------- 256
T +H A G E+ KLL HGAD ++ KEGDT + D +R
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810
Query: 257 ------------------------------------LNRYKIIKLLLLHGADMMTKNLAG 280
N ++ + LL HGAD+ ++ G
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
Query: 281 KTP 283
P
Sbjct: 871 LIP 873
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 85.5 bits (210), Expect = 6e-17
Identities = 55/167 (32%), Positives = 87/167 (52%), Gaps = 11/167 (6%)
Query: 117 ELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADT 176
E KKRK +KR S + + + ++L+AA G ++ ++ +G +
Sbjct: 21 EPEKKRKHRKR-----SRDRKKKSDA------NASYLRAARAGHLEKALDYIKNGVDINI 69
Query: 177 CDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSH 236
C+Q ALH AS EGH+E++ +LL A VD + TA+H A G EVVK+L ++
Sbjct: 70 CNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 237 GADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA+ N + + G T L+ A + N +++K LL +GA G TP
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Score = 75.1 bits (183), Expect = 8e-14
Identities = 43/132 (32%), Positives = 67/132 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E L G S + T +H A+ GH+ I+ +L+ +GA+ + +
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+H A R G EVV+ L GA + K+ T LH + RL + I++ LL GA
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 275 TKNLAGKTPTDL 286
+G TP L
Sbjct: 527 AATTSGYTPLHL 538
Score = 70.5 bits (171), Expect = 2e-12
Identities = 39/128 (30%), Positives = 63/128 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + ++ L + + ++ T LH A+ E + + E L++ GA VD Q ++
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H C G++++V L H A N + K G T LH A + II +LL + A
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 275 TKNLAGKT 282
+ G T
Sbjct: 791 ELTVNGNT 798
Score = 70.1 bits (170), Expect = 3e-12
Identities = 39/113 (34%), Positives = 65/113 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++V+ + L + D + TALH ASL G E+++ L+ NGA V+ Q +
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLL 267
T ++ A + HLEVVK L +GA ++ ++G T L A++ +++ LLL
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Score = 69.3 bits (168), Expect = 4e-12
Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L + GK ++++ L G S + T LH ++ EGH ++ LLD+GA+
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ + T +H A + G LEV LL A + K G T LH A + K+ LL
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 267 LLHGADMMTKNLAGKTP 283
L GA G TP
Sbjct: 618 LDQGASPHAAAKNGYTP 634
Score = 68.9 bits (167), Expect = 6e-12
Identities = 40/129 (31%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ + + G S +T + TALH A+ G E++ L+ +GA V+ + + D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + R G ++V+ L GA N G T LH + R + LL HGA +
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 560 ITTKKGFTP 568
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 3/150 (2%)
Query: 134 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 193
H P + G E AA G+ +V+ + DG + + +T LH ++ G
Sbjct: 455 HGASPNTTNVRG---ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 194 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHD 253
+I+++LL GA+ + T +H + R GH +V L HGA ++ K+G T LH
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571
Query: 254 AVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
A + + ++ LLL A +G TP
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
Score = 66.6 bits (161), Expect = 3e-11
Identities = 40/129 (31%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + K L + +AD + T LH A+ G++ + LL+ A VDF R D
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + G+ +VKLL GA + + ++G T LH R +++++LL A ++
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 275 TKNLAGKTP 283
+K G +P
Sbjct: 329 SKTKNGLSP 337
Score = 65.1 bits (157), Expect = 8e-11
Identities = 37/129 (28%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M + L G A+ + ++H A+ EGH++++ LL A V+ ++
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + + V ++L + GA + + K G T LH KI+ LL H A +
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
Query: 275 TKNLAGKTP 283
K G TP
Sbjct: 758 AKTKNGYTP 766
Score = 64.7 bits (156), Expect = 1e-10
Identities = 40/129 (31%), Positives = 61/129 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G +++ L G D + T LH + GH +++E LLD A + + +
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL V+LL H + + TALH A YK+ K+LL A+
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Query: 275 TKNLAGKTP 283
K L G TP
Sbjct: 395 AKALNGFTP 403
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/128 (32%), Positives = 62/128 (48%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A G +V+E L + + + LH A+ H+ ++ LL + VD
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
TA+H A GH +V K+L A+ N + G T LH A + NR K+++LLL HGA +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 276 KNLAGKTP 283
+G TP
Sbjct: 429 VTESGLTP 436
Score = 63.9 bits (154), Expect = 2e-10
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 1/112 (0%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E LL +GA++ T +H A GH+ +V L HGA N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL-VQLWQAD 293
+ G+TALH A R + ++++ L+ GA + K +TP + +L +AD
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Score = 62.4 bits (150), Expect = 5e-10
Identities = 40/129 (31%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA KV L G S + T LH A+ + M+I LL+ GA + R
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
++H A + GH+++V LL A+ N+ +K G T LH A + +R + ++L+ GA +
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 725 AQTKMGYTP 733
Score = 61.2 bits (147), Expect = 1e-09
Identities = 34/100 (34%), Positives = 53/100 (53%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH ++ + LLD A + + T +H AC+ ++V++LL HGA
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
+ G T +H A + I+ L+ HGA T N+ G+T
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
Score = 58.9 bits (141), Expect = 6e-09
Identities = 37/132 (28%), Positives = 62/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V L S D + T LH A+ + ++ LLD GA+ +
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +++ L +GAD N ++G ++H A + ++ LLL A++
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 275 TKNLAGKTPTDL 286
N +G TP L
Sbjct: 692 LSNKSGLTPLHL 703
Score = 58.2 bits (139), Expect = 1e-08
Identities = 37/115 (32%), Positives = 56/115 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L + D + T LH AS G+ +++ LLD GA +D + R
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLH 269
T +H R GH +VV++L A + K G + LH A + + ++LLL H
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 67/129 (51%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A++ G+ +V++ + +G + + Q T L+ A+ E H+E+++ LLDNGA+
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH +VV LL + + + K ALH A R + K LLL + +
Sbjct: 174 FTPLAVALQQGHDQVVSLL----LENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229
Query: 275 TKNLAGKTP 283
++ +G TP
Sbjct: 230 VESKSGFTP 238
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/121 (28%), Positives = 57/121 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA E ++ V E + G D + T LH G+++I+ LL + A V+ + +
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH ++ +L + A N G+TAL A RL ++ L + + M
Sbjct: 764 YTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETM 823
Query: 275 T 275
T
Sbjct: 824 T 824
Score = 49.7 bits (117), Expect = 4e-06
Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 7/138 (5%)
Query: 149 EETFLKAAV---EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGA 205
E+ F AV +G +V+ L + DT + R ALH A+ + + LL N
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDN 226
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKL 265
D + + T +H A G++ V LL + A + + T LH A + ++KL
Sbjct: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 266 LLLHGADMMTKNLAGKTP 283
LL GA + K G TP
Sbjct: 287 LLDRGAKIDAKTRDGLTP 304
Score = 33.5 bits (75), Expect = 0.26
Identities = 20/69 (28%), Positives = 31/69 (44%)
Query: 221 ACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 280
A R GHLE +G D N+ ++ G ALH A + +++ LL A++ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 281 KTPTDLVQL 289
T + L
Sbjct: 108 NTALHIASL 116
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 85.1 bits (209), Expect = 8e-17
Identities = 55/163 (33%), Positives = 81/163 (49%), Gaps = 4/163 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA K E S + D+ R+ALH A GH+E + LL+ GA+++ D+ +
Sbjct: 114 AAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+HWA GHLEV+KLL + GAD +D++G LH A + +++K LL GA++
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSG 317
N G T + + A+E GA N PND G
Sbjct: 234 EPNAFGNTALH-IACYLGQDAVAIELVNAGANVN---QPNDKG 272
Score = 72.4 bits (176), Expect = 5e-13
Identities = 44/129 (34%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A G ++ + L G S + CD+ R LH A+ GH+E+L+ L+ GA + +DR
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+H A G +EVVK L GA+ + + G+TALH A L + + L+ GA++
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 275 TKNLAGKTP 283
N G TP
Sbjct: 267 QPNDKGFTP 275
Score = 68.2 bits (165), Expect = 1e-11
Identities = 43/127 (33%), Positives = 64/127 (50%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+AA KV+ LA + D+ +T LH A+ + E L ++++ DR
Sbjct: 80 RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
+A+H A GHLE V LL + GA NV DK+ LH A L +++KLL+ GAD+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 274 MTKNLAG 280
K+ G
Sbjct: 200 GCKDRKG 206
Score = 65.1 bits (157), Expect = 8e-11
Identities = 43/136 (31%), Positives = 64/136 (47%), Gaps = 4/136 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEILEKLLDNGATVDFQDRL 213
A G + +E A G SA ++ R+ T LH A+ GH + L L+D+G D D +
Sbjct: 625 ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM 684
Query: 214 DC---TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
D T + A GH++ V LL G+ + D G TALH + LL H
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744
Query: 271 ADMMTKNLAGKTPTDL 286
A ++ ++ G+TP L
Sbjct: 745 AFVLCRDFKGRTPIHL 760
Score = 64.7 bits (156), Expect = 1e-10
Identities = 38/107 (35%), Positives = 58/107 (54%)
Query: 148 DEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
D+ ++A ++ + L+ + + DQ RRT LH A+ G + IL+ LL +GA V
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDA 254
+ +D L T +H A + +V+ LL +H AD N RDK T LH A
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA 114
Score = 63.2 bits (152), Expect = 3e-10
Identities = 45/142 (31%), Positives = 73/142 (51%), Gaps = 1/142 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++V++ +A G D+ LH A+ G +E+++ LL GA +D +
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALH-DAVRLNRYKIIKLLLLHGADM 273
TA+H AC G V L + GA+ N + +G T LH AV N ++LL+ +GAD+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 274 MTKNLAGKTPTDLVQLWQADTR 295
++ GK+P + + TR
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTR 321
Score = 57.4 bits (137), Expect = 2e-08
Identities = 44/147 (29%), Positives = 63/147 (42%), Gaps = 18/147 (12%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ + + +G D D+F T LH A+ GH ++ L+ NGA + D
Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHD 372
Query: 215 CTAMHWA--------CR-----GGHLEVVKLLQ-----SHGADTNVRDKEGDTALHDAVR 256
+H A CR G +V L S G D N D G T LH A
Sbjct: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAAS 432
Query: 257 LNRYKIIKLLLLHGADMMTKNLAGKTP 283
+ + LLL GAD+ ++ G+TP
Sbjct: 433 GGNVECLNLLLSSGADLRRRDKFGRTP 459
Score = 57.0 bits (136), Expect = 2e-08
Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 22/223 (9%)
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
+A + L L+ L+ H G + L +G E++ G LI+ RK
Sbjct: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECV--------EVLTAHGASALIKERK 650
Query: 121 KRKQKKRDALAASHEPP-------PEPEEITGPVD---EETFLKAAVEGKMKVIEKFLAD 170
++ A A+ H E +IT +D + + A + G + + L
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 171 GGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVV 230
G +AD D RTALHR ++ G + L LLD+ A V +D T +H A GH V+
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
Query: 231 KLLQSHGADTNVRDK----EGDTALHDAVRLNRYKIIKLLLLH 269
+ L T+ D G + +H A ++LLL H
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 55.8 bits (133), Expect = 5e-08
Identities = 43/170 (25%), Positives = 70/170 (41%), Gaps = 34/170 (20%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEI------------------ 196
AA G+++V++ L G D + F TALH A G +
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 197 ----------------LEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
LE L++NGA V++Q + + +H A G ++L +G++
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
Query: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLW 290
+ DK G+T LH A R +I L+ +GAD + + P L L+
Sbjct: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Score = 54.7 bits (130), Expect = 1e-07
Identities = 32/97 (32%), Positives = 49/97 (50%)
Query: 165 EKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRG 224
E L+ G +T D RT LH A+ G++E L LL +GA + +D+ T +H+A
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 225 GHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYK 261
G + L + GA N D +G + LH A + Y+
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
Score = 52.8 bits (125), Expect = 4e-07
Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 7/148 (4%)
Query: 131 AASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASL 190
A H P E P+ E +A +E L +G D+ TA+H A+
Sbjct: 505 AEPHTPSSHDAEEDEPLKESRRKEAFF-----CLEFLLDNGADPSLRDRQGYTAVHYAAA 559
Query: 191 EGHMEILEKLLDNGATV--DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGD 248
G+ + LE LL+ D + + + +H A GH E +K L + +VRD +G
Sbjct: 560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619
Query: 249 TALHDAVRLNRYKIIKLLLLHGADMMTK 276
TAL A + +++L HGA + K
Sbjct: 620 TALFLATERGSTECVEVLTAHGASALIK 647
Score = 47.4 bits (111), Expect = 2e-05
Identities = 34/128 (26%), Positives = 59/128 (46%), Gaps = 5/128 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++ + L+ G D+F RT LH A+ G + L+ GA V+ D
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
C+ +H+A + + + H ++ D E D L ++ R + ++ LL +GAD
Sbjct: 490 CSPLHYAAAS---DTYRRAEPHTPSSH--DAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 275 TKNLAGKT 282
++ G T
Sbjct: 545 LRDRQGYT 552
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/99 (29%), Positives = 48/99 (48%)
Query: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
L +A +E + LL ++ D+ T +H A G + +++LL GA+ N +D
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 245 KEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
T LH A K++ LLL H AD+ ++ +TP
Sbjct: 72 TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTP 110
Score = 46.6 bits (109), Expect = 3e-05
Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 4/146 (2%)
Query: 141 EEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKL 200
E++ + AA G + ++ + D D RTAL A+ G E +E L
Sbjct: 578 EDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
Query: 201 LDNGATVDFQDR-LDCTAMHWACRGGHLEVVKLLQSHG--AD-TNVRDKEGDTALHDAVR 256
+GA+ ++R T +H A GH + + LL G AD T+V D G T L A+
Sbjct: 638 TAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIM 697
Query: 257 LNRYKIIKLLLLHGADMMTKNLAGKT 282
+ LLL G+ +L G+T
Sbjct: 698 NGHVDCVHLLLEKGSTADAADLRGRT 723
Score = 46.2 bits (108), Expect = 4e-05
Identities = 37/133 (27%), Positives = 55/133 (41%), Gaps = 4/133 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNG-ATVDFQDRL 213
AA + + L + D RTAL A+ G +E LL G A + D
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADT---NVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
TA+H AC GH + ++ + D N + LH A R +++ LL HG
Sbjct: 925 KNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
Query: 271 ADMMTKNLAGKTP 283
A ++ + G TP
Sbjct: 985 ATVLAVDEEGHTP 997
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/133 (29%), Positives = 60/133 (45%), Gaps = 5/133 (3%)
Query: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
LH A+ GH E L+ L + +D +D TA+ A G E V++L +HGA +++
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 245 KEGD-TALHDAVRLNRYKIIKLLLLHG--ADMM-TKNLAGKTPTDL-VQLWQADTRHALE 299
++ T LH A + LL+ G AD+ + G+TP L + D H L
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 300 HPEPGAEHNGLEG 312
A+ L G
Sbjct: 709 EKGSTADAADLRG 721
Score = 43.9 bits (102), Expect = 2e-04
Identities = 37/105 (35%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSAD--TCDQFRRTALHRASLEGH----MEILEKLLDNG 204
T L A E +FL G AD D+ + TALH A +GH + IL + D G
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLG 952
Query: 205 ATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDT 249
L +H A R G VV+ L SHGA D+EG T
Sbjct: 953 LINATNSALQMP-LHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
Score = 42.0 bits (97), Expect = 7e-04
Identities = 39/130 (30%), Positives = 52/130 (40%), Gaps = 16/130 (12%)
Query: 182 RTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHG-ADT 240
RT LH A+ ++ L LL + A V+ D TA+ A G V+ L G AD
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADL 918
Query: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH 300
V D+ +TALH A K ++L D+ N T AL+
Sbjct: 919 TVLDENKNTALHLACSKGHEKCALMILAETQDLGLINA---------------TNSALQM 963
Query: 301 PEPGAEHNGL 310
P A NGL
Sbjct: 964 PLHIAARNGL 973
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 83.2 bits (204), Expect = 3e-16
Identities = 40/101 (39%), Positives = 60/101 (59%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LHRA++ G +++L+ GA V+ +D TA+H AC G+ +V K L + GA+ N
Sbjct: 170 TRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNT 229
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
+ + DT LHDA YK++KLLL +G + N G+TP
Sbjct: 230 KGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETP 270
Score = 62.0 bits (149), Expect = 7e-10
Identities = 38/117 (32%), Positives = 64/117 (54%), Gaps = 3/117 (2%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+AA+ G + I++ +++G + D TALH A G+ ++ ++LL GA V+ +
Sbjct: 174 RAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLD 233
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
D T +H A GH +VVKLL +G + +++G+T L A N ++ LLL G
Sbjct: 234 DDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA---NSPTMVNLLLGKG 287
Score = 31.6 bits (70), Expect = 1.0
Identities = 17/42 (40%), Positives = 24/42 (57%)
Query: 241 NVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 282
N R++ G+T LH A + IK L+ GAD+ K+ AG T
Sbjct: 162 NKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWT 203
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 81.6 bits (200), Expect = 8e-16
Identities = 46/134 (34%), Positives = 73/134 (54%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G+ ++++ L G + +Q T LH A+ + EI LL+ GA D +D +
Sbjct: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TAMH A G+L+++ +L + A TN++D EG+T LH A R + KLL+ GA +
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
Query: 275 TKNLAGKTPTDLVQ 288
+N KTP + +
Sbjct: 200 IENKEEKTPLQVAK 213
Score = 74.7 bits (182), Expect = 1e-13
Identities = 49/123 (39%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Query: 156 AVEGKMKVI-EKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A GK++ + E LAD A DQ RTALH A GH EI+E LL G V+ +D
Sbjct: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A G E+VK L GA N ++ G T LH A NR++I +LL GA+
Sbjct: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
Query: 275 TKN 277
K+
Sbjct: 134 AKD 136
Score = 61.6 bits (148), Expect = 9e-10
Identities = 39/132 (29%), Positives = 63/132 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A G +++E L G + D + LH A+ G EI++ LL GA V+ ++
Sbjct: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
CT +H+A E+ +L GA+ + +D TA+H A K+I +LL + A
Sbjct: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166
Query: 275 TKNLAGKTPTDL 286
++ G TP L
Sbjct: 167 IQDTEGNTPLHL 178
Score = 59.7 bits (143), Expect = 3e-09
Identities = 33/89 (37%), Positives = 46/89 (51%)
Query: 195 EILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDA 254
E+ E +L + + D+ TA+HWAC GH E+V+ L G N +D G + LH A
Sbjct: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
Query: 255 VRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
R +I+K LL GA + N G TP
Sbjct: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTP 109
Score = 30.4 bits (67), Expect = 2.2
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+AA +G +K+I L S + D T LH A E +E + L+ GA++ +++
Sbjct: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
Query: 214 DCTAMHWACRGG 225
+ T + A +GG
Sbjct: 205 EKTPLQVA-KGG 215
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 80.1 bits (196), Expect = 2e-15
Identities = 49/135 (36%), Positives = 72/135 (53%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +G KV+ + G + + DQ TAL A+ GH E++ LL G VD D
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+ A GGH ++V L HGA+ N D EG TAL A + +I++ LL HGA++
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 704
Query: 275 TKNLAGKTPTDLVQL 289
+++ G+T + L
Sbjct: 705 HEDVDGRTALSVAAL 719
Score = 79.0 bits (193), Expect = 5e-15
Identities = 40/117 (34%), Positives = 71/117 (60%)
Query: 158 EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTA 217
+G M++++ +A + D +R+AL A+ +GH+++++ L+++GA VD TA
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 218 MHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ A + GH++VV++L HGAD N D+ G TA+ A + +IIKLL +GA +
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
Score = 77.8 bits (190), Expect = 1e-14
Identities = 41/117 (35%), Positives = 65/117 (55%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+EG ++E + G + D R L+ +LE + + E L+NGA V+ D
Sbjct: 920 AALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEG 979
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271
TA+H +C GH+E+V++L ++ AD N D E +AL A K+++LL+ HGA
Sbjct: 980 RTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036
Score = 74.3 bits (181), Expect = 1e-13
Identities = 44/127 (34%), Positives = 72/127 (56%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A+E ++ + E FL +G + + D RTALH + +GHME+++ L+ A V+ D
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+A+ A GH++VV+LL HGA + +G TAL A + ++++LL HGAD
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
Query: 276 KNLAGKT 282
+ G+T
Sbjct: 1074 ADQFGRT 1080
Score = 70.5 bits (171), Expect = 2e-12
Identities = 51/142 (35%), Positives = 70/142 (49%), Gaps = 6/142 (4%)
Query: 148 DEETFLKAAVEGKMK-VIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D T L+AA G + ++ L G + D RTAL A+ GH EI+E LLD+GA
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702
Query: 207 VDFQD-----RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYK 261
V+ +D L A+ GH VV LL GA+ + DK+G T L A
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 262 IIKLLLLHGADMMTKNLAGKTP 283
++ LLL GAD+ + G+TP
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTP 784
Score = 68.2 bits (165), Expect = 1e-11
Identities = 42/137 (30%), Positives = 67/137 (48%), Gaps = 1/137 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + E + G + D R AS EGH + ++ LL+N + +D +
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
A+ A GH ++V+LL SHGAD N +D +G L+ N+ + + L +GA++
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973
Query: 275 TKNLAGKTPTDLVQLWQ 291
+ G+T V WQ
Sbjct: 974 ASDAEGRTALH-VSCWQ 989
Score = 67.4 bits (163), Expect = 2e-11
Identities = 43/128 (33%), Positives = 62/128 (48%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A +G V+ + G D CD+ T L A+ EGH+++++ LL+ GA VD D
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
T + A GH VV L GA + D EG T L A ++++ LL G D
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 276 KNLAGKTP 283
++ AG TP
Sbjct: 843 RDDAGWTP 850
Score = 64.7 bits (156), Expect = 1e-10
Identities = 53/163 (32%), Positives = 70/163 (42%), Gaps = 1/163 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L AA EG + V++ L G D D RT L A+ GH ++ LL GA VD D
Sbjct: 753 LVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 812
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
T + A G++EVV+ L G D N RD G T LH A I + L+ GA
Sbjct: 813 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
Query: 273 MMTKNLAGKTPTDLV-QLWQADTRHALEHPEPGAEHNGLEGPN 314
+ G+ P L Q D L + + G +G N
Sbjct: 873 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN 915
Score = 63.2 bits (152), Expect = 3e-10
Identities = 47/155 (30%), Positives = 72/155 (46%), Gaps = 3/155 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V+ ++ G + D T L A+ +GH +++ L+ GA ++ D+
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+ A GGH EVV L G + D + TAL A I+ LL HGA++
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 275 TKNLAGKTPTDLVQLWQADTRHALEH-PEPGAEHN 308
+ G+T L+ R +EH + GAE N
Sbjct: 672 KADNEGRTA--LIAAAYMGHREIVEHLLDHGAEVN 704
Score = 62.0 bits (149), Expect = 7e-10
Identities = 33/87 (37%), Positives = 56/87 (64%), Gaps = 2/87 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSAD-TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
AA +G +KV++ + G D TC+Q TAL A+ EGH+++++ LL++GA + D+
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQ-GATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADT 240
TAM A + GH +++KLL+ +GA +
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASS 1104
Score = 60.5 bits (145), Expect = 2e-09
Identities = 35/107 (32%), Positives = 54/107 (50%)
Query: 164 IEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACR 223
I L +G S + CD RT L A+ G ++++ L+ GA ++ +D T + A R
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 224 GGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
GH +VV L GA+ N D++G TAL A +++ LL G
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Score = 59.3 bits (142), Expect = 5e-09
Identities = 38/127 (29%), Positives = 62/127 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ +G ++V+ L G + D T LH A+ EGH I E L++ GA + D
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
A + GH + V++L + ++ + R +G AL A I++LL HGAD+
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 275 TKNLAGK 281
K+ G+
Sbjct: 941 CKDADGR 947
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 160 KMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMH 219
K + + + L G+ + R + + R +LE + + LLDNGA+V+ D T +
Sbjct: 492 KEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE-DSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 220 WACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADM 273
A G L+VV LL S GAD + D G T L A R K++ L+ GA++
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 4/93 (4%)
Query: 195 EILEKLLDNGATVDFQD-RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHD 253
E+L+ L+ GA V+ +D R C R + ++ L +GA N D G T L +
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE---DSIRTLLDNGASVNQCDSNGRTLLAN 551
Query: 254 AVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 286
A ++ LL+ GAD+ ++ G TP L
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 79.7 bits (195), Expect = 3e-15
Identities = 43/128 (33%), Positives = 69/128 (53%)
Query: 158 EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTA 217
+G ++++ L G + D+ RT L A+ EGH+ ++ LL GA++ D+ TA
Sbjct: 1077 QGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTA 1136
Query: 218 MHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 277
+ WAC GHL VV+ L +GA T+ DK G T L A ++++ L+ HGA + +
Sbjct: 1137 LSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD 1196
Query: 278 LAGKTPTD 285
+G P D
Sbjct: 1197 YSGMRPLD 1204
Score = 65.1 bits (157), Expect = 8e-11
Identities = 45/142 (31%), Positives = 68/142 (47%), Gaps = 1/142 (0%)
Query: 150 ETFLKAAV-EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVD 208
ET L AA GK++V L G + ++ L +GH +I++ LL +GA V+
Sbjct: 1035 ETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN 1094
Query: 209 FQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLL 268
D+ T + A GHL V L + GA + DKEG TAL A +++ L+
Sbjct: 1095 MADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVD 1154
Query: 269 HGADMMTKNLAGKTPTDLVQLW 290
+GA + G+TP DL +
Sbjct: 1155 NGAATDHADKNGRTPLDLAAFY 1176
Score = 65.1 bits (157), Expect = 8e-11
Identities = 42/119 (35%), Positives = 57/119 (47%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
+ AA EG + ++ LA G S D+ TAL A L+GH+ ++ L+DNGA D D+
Sbjct: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271
T + A G EVV+ L HGA D G L AV ++ LL GA
Sbjct: 1165 NGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/76 (31%), Positives = 37/76 (48%)
Query: 192 GHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTAL 251
G+ E++ LL+ GA VD T + +A G+L +V LL A + DK G AL
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
Query: 252 HDAVRLNRYKIIKLLL 267
A +++K L+
Sbjct: 956 VHAALRGHLEVVKFLI 971
Score = 37.0 bits (84), Expect = 0.024
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 159 GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL-DCTA 217
G +++ L G + D + T L A+ G++ I+ L A VD D+ C
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
Query: 218 MHWACRGGHLEVVKLL 233
+H A RG HLEVVK L
Sbjct: 956 VHAALRG-HLEVVKFL 970
Score = 36.2 bits (82), Expect = 0.041
Identities = 37/150 (24%), Positives = 60/150 (40%), Gaps = 25/150 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ D D+ + AL A+L GH+E+++ L+ T+ Q +
Sbjct: 925 AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984
Query: 215 CTAMHW-------ACRGGHLEVVKLLQSHGADTNVRDKE--------------GDTALHD 253
H A G+ E+V L D +D+E G+TAL
Sbjct: 985 FKKSHAIQQALIAAASMGYTEIVSYL----LDLPEKDEEEVERAQINSFDSLWGETALTA 1040
Query: 254 AVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
A + ++ +LLL GA + N G P
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVP 1070
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 79.3 bits (194), Expect = 4e-15
Identities = 42/103 (40%), Positives = 58/103 (56%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH AS++G + +E LL NG+ + +D T +H AC GHL+VV+LL H A N
Sbjct: 430 TLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNT 489
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTD 285
+ D+ LHDA + I+KLLL +GA N+ G P D
Sbjct: 490 TGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD 532
Score = 57.8 bits (138), Expect = 1e-08
Identities = 32/93 (34%), Positives = 53/93 (56%), Gaps = 1/93 (1%)
Query: 150 ETFLK-AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVD 208
ET L A+++G + +E L +G + D T LH A GH++++E LL + A V+
Sbjct: 429 ETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVN 488
Query: 209 FQDRLDCTAMHWACRGGHLEVVKLLQSHGADTN 241
+ + +H A + GH+++VKLL S+GA N
Sbjct: 489 TTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRN 521
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 79.3 bits (194), Expect = 4e-15
Identities = 57/184 (30%), Positives = 82/184 (44%), Gaps = 39/184 (21%)
Query: 148 DEET-FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNG-A 205
D+ T ++AA ++ ++ + G D D T LH A+ +GH E+++ LL NG
Sbjct: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKE------------------- 246
V+ QD T M WA H+++VKLL S G+D N+RD E
Sbjct: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 924
Query: 247 --------------GDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV----Q 288
GD+ LH A R NRY + L L +D+ KN G+TP Q
Sbjct: 925 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 984
Query: 289 LWQA 292
+W A
Sbjct: 985 VWSA 988
Score = 66.2 bits (160), Expect = 4e-11
Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 7/145 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTC--DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
+A +G+++ + L DG + Q +R+ LH A+ GH++I L+ GA +D
Sbjct: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG-A 271
T + A HLE VK L GA + +D EG T LH A + Y++++ LL +G
Sbjct: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
Query: 272 DMMTKNLAGKTPTDLVQLWQADTRH 296
D+ ++ G TP +W + +H
Sbjct: 865 DVNCQDDGGWTP----MIWATEYKH 885
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/129 (35%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH EV K L + A N + K+ T LH A R+ ++KLLL + A+
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 275 TKNLAGKTP 283
AG TP
Sbjct: 531 LATTAGHTP 539
Score = 75.5 bits (184), Expect = 6e-14
Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 6/168 (3%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
++ +K++++ R S + + + T +FL+AA G + L +G +
Sbjct: 19 LQEQKEKEESNRKRRNRSRDRKKKADAAT------SFLRAARSGNLDKALDHLRNGVDIN 72
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
TC+Q LH AS EGH++++ +LL ++ + TA+H A G EVV+ L +
Sbjct: 73 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 132
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
+GA+ N + ++G T L+ A + N +++K LL +GA+ G TP
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G++++VK L H AD N + K G + LH A + I+ LLL +GA
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 795 EVSSDGTTP 803
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + GH+ V +L HG + + G T LH A K++K LL H AD+
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 275 TKNLAGKTP 283
K G +P
Sbjct: 762 AKTKLGYSP 770
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/129 (32%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VKLL + A+ N+ G T LH A R + + LL A
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 564 CMTKKGFTP 572
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + + +
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL+ V+LL + A+ + + T LH A +++ K+LL GA
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 275 TKNLAGKTP 283
++ L G TP
Sbjct: 399 SRALNGFTP 407
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 3/168 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 266
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
HGA + K G + +H A + + ++LLL + A++ L TP
Sbjct: 327 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374
Score = 65.1 bits (157), Expect = 8e-11
Identities = 38/116 (32%), Positives = 66/116 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
T ++ A + HLEVVK L +GA+ NV ++G T L A++ ++ L+ +G
Sbjct: 145 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/146 (32%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 363 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRL 257
E LL GA++D T +H A GHL +VK L GA NV + + +T LH A R
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTP 283
++ K LL + A + K +TP
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTP 506
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G + V +LL A N K G T LH AV N I+KLL
Sbjct: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Query: 267 LLHGADMMTKNLAGKTP 283
L G + G TP
Sbjct: 622 LPRGGSPHSPAWNGYTP 638
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/129 (27%), Positives = 59/129 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH E+V LL S A+ N+ +K G T LH + + +L+ HG +
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 729 ATTRMGYTP 737
Score = 56.6 bits (135), Expect = 3e-08
Identities = 40/147 (27%), Positives = 65/147 (44%), Gaps = 14/147 (9%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A EG + V + + G D + T LH AS G++++++ LL + A V+ + +L
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+ +H A + GH ++V LL +GA N +G T L A RL + +L
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--------- 819
Query: 276 KNLAGKTPTDLVQLWQADTRHALEHPE 302
K TD +H + PE
Sbjct: 820 -----KVVTDETSFVLVSDKHRMSFPE 841
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 58/129 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V + L + + + +T LH A+ GH +++ LL+N A +
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH+E V L A K+G T LH A + + ++ +LLL A
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 597 AAGKNGLTP 605
Score = 53.9 bits (128), Expect = 2e-07
Identities = 37/132 (28%), Positives = 61/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A +L++VKLL G + G T LH A + N+ ++ + LL +G
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 275 TKNLAGKTPTDL 286
+++ G TP L
Sbjct: 663 AESVQGVTPLHL 674
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/133 (28%), Positives = 60/133 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V E L + + T LH A +++I++ LL G +
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +EV + L +G N +G T LH A + +++ LLL A+
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 275 TKNLAGKTPTDLV 287
N +G TP LV
Sbjct: 696 LGNKSGLTPLHLV 708
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/108 (32%), Positives = 47/108 (43%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA N + G T LH A R +++LLL GA + TK TP
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +V+ + + G + + Q T L+ A+ E H+E+++ LL+NGA +
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH VV L ++G VR ALH A R + + +LL + +
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 233
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 234 VLSKTGFTP 242
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/129 (35%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH EV K L + A N + K+ T LH A R+ ++KLLL + A+
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 TKNLAGKTP 283
AG TP
Sbjct: 498 LATTAGHTP 506
Score = 75.1 bits (183), Expect = 8e-14
Identities = 44/133 (33%), Positives = 73/133 (54%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVV+ L ++GA+ N + ++G T L+ A + N +++K LL +G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 ADMMTKNLAGKTP 283
A+ G TP
Sbjct: 135 ANQNVATEDGFTP 147
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G++++VK L H AD N + K G + LH A + I+ LLL +GA
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 762 EVSSDGTTP 770
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + GH+ V +L HG + + G T LH A K++K LL H AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 TKNLAGKTP 283
K G +P
Sbjct: 729 AKTKLGYSP 737
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/129 (32%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VKLL + A+ N+ G T LH A R + + LL A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 531 CMTKKGFTP 539
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL+ V+LL + A+ + + T LH A +++ K+LL GA
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 275 TKNLAGKTP 283
++ L G TP
Sbjct: 366 SRALNGFTP 374
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 3/168 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
HGA + K G + +H A + + ++LLL + A++ L TP
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Score = 65.1 bits (157), Expect = 8e-11
Identities = 38/116 (32%), Positives = 66/116 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
T ++ A + HLEVVK L +GA+ NV ++G T L A++ ++ L+ +G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/146 (32%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRL 257
E LL GA++D T +H A GHL +VK L GA NV + + +T LH A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTP 283
++ K LL + A + K +TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G + V +LL A N K G T LH AV N I+KLL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LLHGADMMTKNLAGKTP 283
L G + G TP
Sbjct: 589 LPRGGSPHSPAWNGYTP 605
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/129 (27%), Positives = 59/129 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH E+V LL S A+ N+ +K G T LH + + +L+ HG +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 696 ATTRMGYTP 704
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A EG + V + + G D + T LH AS G++++++ LL + A V+ + +L
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+ +H A + GH ++V LL +GA N +G T L A RL + +L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--------- 786
Query: 276 KNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 319
K TD +H + PE E L+ D G E
Sbjct: 787 -----KVVTDETSFVLVSDKHRMSFPETVDEI--LDVSEDEGEE 823
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 58/129 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V + L + + + +T LH A+ GH +++ LL+N A +
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH+E V L A K+G T LH A + + ++ +LLL A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 564 AAGKNGLTP 572
Score = 53.9 bits (128), Expect = 2e-07
Identities = 37/132 (28%), Positives = 61/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A +L++VKLL G + G T LH A + N+ ++ + LL +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 TKNLAGKTPTDL 286
+++ G TP L
Sbjct: 630 AESVQGVTPLHL 641
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/133 (28%), Positives = 60/133 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V E L + + T LH A +++I++ LL G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +EV + L +G N +G T LH A + +++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 275 TKNLAGKTPTDLV 287
N +G TP LV
Sbjct: 663 LGNKSGLTPLHLV 675
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/108 (32%), Positives = 47/108 (43%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA N + G T LH A R +++LLL GA + TK TP
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +V+ + + G + + Q T L+ A+ E H+E+++ LL+NGA +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH VV L ++G VR ALH A R + + +LL + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 201 VLSKTGFTP 209
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/101 (25%), Positives = 53/101 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
K+G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/129 (35%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH EV K L + A N + K+ T LH A R+ ++KLLL + A+
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 TKNLAGKTP 283
AG TP
Sbjct: 498 LATTAGHTP 506
Score = 75.1 bits (183), Expect = 8e-14
Identities = 44/133 (33%), Positives = 73/133 (54%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVV+ L ++GA+ N + ++G T L+ A + N +++K LL +G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 ADMMTKNLAGKTP 283
A+ G TP
Sbjct: 135 ANQNVATEDGFTP 147
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G++++VK L H AD N + K G + LH A + I+ LLL +GA
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 762 EVSSDGTTP 770
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + GH+ V +L HG + + G T LH A K++K LL H AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 TKNLAGKTP 283
K G +P
Sbjct: 729 AKTKLGYSP 737
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/129 (32%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VKLL + A+ N+ G T LH A R + + LL A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 531 CMTKKGFTP 539
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL+ V+LL + A+ + + T LH A +++ K+LL GA
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 275 TKNLAGKTP 283
++ L G TP
Sbjct: 366 SRALNGFTP 374
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 3/168 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
HGA + K G + +H A + + ++LLL + A++ L TP
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Score = 65.1 bits (157), Expect = 8e-11
Identities = 38/116 (32%), Positives = 66/116 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
T ++ A + HLEVVK L +GA+ NV ++G T L A++ ++ L+ +G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/146 (32%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRL 257
E LL GA++D T +H A GHL +VK L GA NV + + +T LH A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTP 283
++ K LL + A + K +TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G + V +LL A N K G T LH AV N I+KLL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LLHGADMMTKNLAGKTP 283
L G + G TP
Sbjct: 589 LPRGGSPHSPAWNGYTP 605
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/129 (27%), Positives = 59/129 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH E+V LL S A+ N+ +K G T LH + + +L+ HG +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 696 ATTRMGYTP 704
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A EG + V + + G D + T LH AS G++++++ LL + A V+ + +L
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+ +H A + GH ++V LL +GA N +G T L A RL + +L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--------- 786
Query: 276 KNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 319
K TD +H + PE E L+ D G E
Sbjct: 787 -----KVVTDETSFVLVSDKHRMSFPETVDEI--LDVSEDEGEE 823
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 58/129 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V + L + + + +T LH A+ GH +++ LL+N A +
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH+E V L A K+G T LH A + + ++ +LLL A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 564 AAGKNGLTP 572
Score = 53.9 bits (128), Expect = 2e-07
Identities = 37/132 (28%), Positives = 61/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A +L++VKLL G + G T LH A + N+ ++ + LL +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 TKNLAGKTPTDL 286
+++ G TP L
Sbjct: 630 AESVQGVTPLHL 641
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/133 (28%), Positives = 60/133 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V E L + + T LH A +++I++ LL G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +EV + L +G N +G T LH A + +++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 275 TKNLAGKTPTDLV 287
N +G TP LV
Sbjct: 663 LGNKSGLTPLHLV 675
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/108 (32%), Positives = 47/108 (43%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA N + G T LH A R +++LLL GA + TK TP
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +V+ + + G + + Q T L+ A+ E H+E+++ LL+NGA +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH VV L ++G VR ALH A R + + +LL + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 201 VLSKTGFTP 209
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/101 (25%), Positives = 53/101 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
K+G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/129 (35%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH EV K L + A N + K+ T LH A R+ ++KLLL + A+
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 TKNLAGKTP 283
AG TP
Sbjct: 498 LATTAGHTP 506
Score = 75.1 bits (183), Expect = 8e-14
Identities = 44/133 (33%), Positives = 73/133 (54%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVV+ L ++GA+ N + ++G T L+ A + N +++K LL +G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 ADMMTKNLAGKTP 283
A+ G TP
Sbjct: 135 ANQNVATEDGFTP 147
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G++++VK L H AD N + K G + LH A + I+ LLL +GA
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 762 EVSSDGTTP 770
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + GH+ V +L HG + + G T LH A K++K LL H AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 TKNLAGKTP 283
K G +P
Sbjct: 729 AKTKLGYSP 737
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/129 (32%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VKLL + A+ N+ G T LH A R + + LL A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 531 CMTKKGFTP 539
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL+ V+LL + A+ + + T LH A +++ K+LL GA
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 275 TKNLAGKTP 283
++ L G TP
Sbjct: 366 SRALNGFTP 374
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 3/168 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
HGA + K G + +H A + + ++LLL + A++ L TP
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Score = 65.1 bits (157), Expect = 8e-11
Identities = 38/116 (32%), Positives = 66/116 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
T ++ A + HLEVVK L +GA+ NV ++G T L A++ ++ L+ +G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/146 (32%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRL 257
E LL GA++D T +H A GHL +VK L GA NV + + +T LH A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTP 283
++ K LL + A + K +TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G + V +LL A N K G T LH AV N I+KLL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LLHGADMMTKNLAGKTP 283
L G + G TP
Sbjct: 589 LPRGGSPHSPAWNGYTP 605
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/129 (27%), Positives = 59/129 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH E+V LL S A+ N+ +K G T LH + + +L+ HG +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 696 ATTRMGYTP 704
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A EG + V + + G D + T LH AS G++++++ LL + A V+ + +L
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+ +H A + GH ++V LL +GA N +G T L A RL + +L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--------- 786
Query: 276 KNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 319
K TD +H + PE E L+ D G E
Sbjct: 787 -----KVVTDETSFVLVSDKHRMSFPETVDEI--LDVSEDEGEE 823
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 58/129 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V + L + + + +T LH A+ GH +++ LL+N A +
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH+E V L A K+G T LH A + + ++ +LLL A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 564 AAGKNGLTP 572
Score = 53.9 bits (128), Expect = 2e-07
Identities = 37/132 (28%), Positives = 61/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A +L++VKLL G + G T LH A + N+ ++ + LL +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 TKNLAGKTPTDL 286
+++ G TP L
Sbjct: 630 AESVQGVTPLHL 641
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/133 (28%), Positives = 60/133 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V E L + + T LH A +++I++ LL G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +EV + L +G N +G T LH A + +++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 275 TKNLAGKTPTDLV 287
N +G TP LV
Sbjct: 663 LGNKSGLTPLHLV 675
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/108 (32%), Positives = 47/108 (43%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA N + G T LH A R +++LLL GA + TK TP
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +V+ + + G + + Q T L+ A+ E H+E+++ LL+NGA +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH VV L ++G VR ALH A R + + +LL + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 201 VLSKTGFTP 209
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/101 (25%), Positives = 53/101 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
K+G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/129 (35%), Positives = 66/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH EV K L + A N + K+ T LH A R+ ++KLLL + A+
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 TKNLAGKTP 283
AG TP
Sbjct: 498 LATTAGHTP 506
Score = 75.1 bits (183), Expect = 8e-14
Identities = 44/133 (33%), Positives = 73/133 (54%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
+ TA+H A G EVV+ L ++GA+ N + ++G T L+ A + N +++K LL +G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 ADMMTKNLAGKTP 283
A+ G TP
Sbjct: 135 ANQNVATEDGFTP 147
Score = 72.0 bits (175), Expect = 7e-13
Identities = 41/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A G++++VK L H AD N + K G + LH A + I+ LLL +GA
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 762 EVSSDGTTP 770
Score = 70.5 bits (171), Expect = 2e-12
Identities = 42/129 (32%), Positives = 63/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H + GH+ V +L HG + + G T LH A K++K LL H AD+
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 TKNLAGKTP 283
K G +P
Sbjct: 729 AKTKLGYSP 737
Score = 67.8 bits (164), Expect = 1e-11
Identities = 42/129 (32%), Positives = 62/129 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH +VKLL + A+ N+ G T LH A R + + LL A
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 531 CMTKKGFTP 539
Score = 66.2 bits (160), Expect = 4e-11
Identities = 40/129 (31%), Positives = 67/129 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
+ +H A +G HL+ V+LL + A+ + + T LH A +++ K+LL GA
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 275 TKNLAGKTP 283
++ L G TP
Sbjct: 366 SRALNGFTP 374
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/168 (26%), Positives = 79/168 (47%), Gaps = 3/168 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
HGA + K G + +H A + + ++LLL + A++ L TP
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Score = 65.1 bits (157), Expect = 8e-11
Identities = 38/116 (32%), Positives = 66/116 (56%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHG 270
T ++ A + HLEVVK L +GA+ NV ++G T L A++ ++ L+ +G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/146 (32%), Positives = 68/146 (46%), Gaps = 3/146 (2%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRL 257
E LL GA++D T +H A GHL +VK L GA NV + + +T LH A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 NRYKIIKLLLLHGADMMTKNLAGKTP 283
++ K LL + A + K +TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 62.0 bits (149), Expect = 7e-10
Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLL 266
+ T +H A + G + V +LL A N K G T LH AV N I+KLL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LLHGADMMTKNLAGKTP 283
L G + G TP
Sbjct: 589 LPRGGSPHSPAWNGYTP 605
Score = 57.4 bits (137), Expect = 2e-08
Identities = 36/129 (27%), Positives = 59/129 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + GH E+V LL S A+ N+ +K G T LH + + +L+ HG +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 696 ATTRMGYTP 704
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 16/164 (9%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A EG + V + + G D + T LH AS G++++++ LL + A V+ + +L
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMT 275
+ +H A + GH ++V LL +GA N +G T L A RL + +L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL--------- 786
Query: 276 KNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 319
K TD +H + PE E L+ D G E
Sbjct: 787 -----KVVTDETSFVLVSDKHRMSFPETVDEI--LDVSEDEGEE 823
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/129 (29%), Positives = 58/129 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V + L + + + +T LH A+ GH +++ LL+N A +
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A R GH+E V L A K+G T LH A + + ++ +LLL A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 275 TKNLAGKTP 283
G TP
Sbjct: 564 AAGKNGLTP 572
Score = 53.9 bits (128), Expect = 2e-07
Identities = 37/132 (28%), Positives = 61/132 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A +L++VKLL G + G T LH A + N+ ++ + LL +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 TKNLAGKTPTDL 286
+++ G TP L
Sbjct: 630 AESVQGVTPLHL 641
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/133 (28%), Positives = 60/133 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V E L + + T LH A +++I++ LL G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T +H A + +EV + L +G N +G T LH A + +++ LLL A+
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 275 TKNLAGKTPTDLV 287
N +G TP LV
Sbjct: 663 LGNKSGLTPLHLV 675
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/108 (32%), Positives = 47/108 (43%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
GA N + G T LH A R +++LLL GA + TK TP
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +V+ + + G + + Q T L+ A+ E H+E+++ LL+NGA +
Sbjct: 85 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
T + A + GH VV L ++G VR ALH A R + + +LL + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARNDDTRTAAVLLQNDPNPD 200
Query: 275 TKNLAGKTP 283
+ G TP
Sbjct: 201 VLSKTGFTP 209
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/101 (25%), Positives = 53/101 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 283
K+G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 273 MMTKNLAGKTPTDL 286
+ T++ KT D+
Sbjct: 130 VHTQSKFCKTAFDI 143
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
Query: 275 TKN 277
N
Sbjct: 165 NTN 167
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
V Q + TA + G+ ++ ++LQ
Sbjct: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 273 MMTKNLAGKTPTDL 286
+ T++ KT D+
Sbjct: 130 VHTQSKFCKTAFDI 143
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
Query: 275 TKN 277
N
Sbjct: 165 NTN 167
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
V Q + TA + G+ ++ ++LQ
Sbjct: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 273 MMTKNLAGKTPTDL 286
+ T++ KT D+
Sbjct: 130 VHTQSKFCKTAFDI 143
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
Query: 275 TKN 277
N
Sbjct: 165 NTN 167
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
V Q + TA + G+ ++ ++LQ
Sbjct: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
>gi|8051597 GA binding protein transcription factor, beta subunit 1
isoform gamma 1 [Homo sapiens]
Length = 360
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 273 MMTKNLAGKTPTDL 286
+ T++ KT D+
Sbjct: 130 VHTQSKFCKTAFDI 143
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
Query: 275 TKN 277
N
Sbjct: 165 NTN 167
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
V Q + TA + G+ ++ ++LQ
Sbjct: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
>gi|8051599 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 79.3 bits (194), Expect = 4e-15
Identities = 47/134 (35%), Positives = 73/134 (54%), Gaps = 1/134 (0%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L+AA G+ + +A+G T D + LH A+ GH E LL G + D + +
Sbjct: 11 LEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTK 69
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGAD 272
+D T +H A GH +V++L HGAD N +D TALH A N ++++LL+ +GAD
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 273 MMTKNLAGKTPTDL 286
+ T++ KT D+
Sbjct: 130 VHTQSKFCKTAFDI 143
Score = 73.2 bits (178), Expect = 3e-13
Identities = 44/123 (35%), Positives = 63/123 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G E L G S D + RT LH A+ EGH I+E LL +GA V+ +D L
Sbjct: 45 AAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLK 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMM 274
TA+HWA H EVV+LL +GAD + + K TA ++ + ++L + + +
Sbjct: 105 MTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQI 164
Query: 275 TKN 277
N
Sbjct: 165 NTN 167
Score = 49.7 bits (117), Expect = 4e-06
Identities = 28/88 (31%), Positives = 43/88 (48%)
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
VD AA EG ++E L G + D + TALH A+ H E++E L+ GA
Sbjct: 70 VDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGAD 129
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
V Q + TA + G+ ++ ++LQ
Sbjct: 130 VHTQSKFCKTAFDISIDNGNEDLAEILQ 157
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,486,548
Number of Sequences: 37866
Number of extensions: 623470
Number of successful extensions: 4911
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 2288
Number of HSP's gapped (non-prelim): 1879
length of query: 327
length of database: 18,247,518
effective HSP length: 103
effective length of query: 224
effective length of database: 14,347,320
effective search space: 3213799680
effective search space used: 3213799680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.