Search of human proteins with 193083125

Search of human proteins with 193083125

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083125 MAP/microtubule affinity-regulating kinase 3
isoform a [Homo sapiens]
         (753 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...  1497   0.0  
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...  1472   0.0  
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...  1434   0.0  
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...  1397   0.0  
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...  1035   0.0  
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor...   942   0.0  
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   920   0.0  
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   915   0.0  
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   909   0.0  
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   908   0.0  
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   876   0.0  
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   807   0.0  
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        381   e-105
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         354   2e-97
gi|116256471 SNF1-like kinase [Homo sapiens]                          350   2e-96
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               286   4e-77
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              281   1e-75
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    278   1e-74
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   269   6e-72
gi|156105707 SNF related kinase [Homo sapiens]                        268   1e-71
gi|156105705 SNF related kinase [Homo sapiens]                        268   1e-71
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   266   7e-71
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               261   2e-69
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           256   4e-68
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   256   7e-68
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       256   7e-68
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   222   9e-58
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            189   1e-47
gi|16418343 testis-specific serine kinase 3 [Homo sapiens]            188   2e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens]           184   3e-46

>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score = 1497 bits (3876), Expect = 0.0
 Identities = 753/753 (100%), Positives = 753/753 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480
           HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480

Query: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540
           ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
Sbjct: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540

Query: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600
           THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
Sbjct: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600

Query: 601 STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 660
           STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF
Sbjct: 601 STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 660

Query: 661 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 720
           TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
Sbjct: 661 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 720

Query: 721 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 721 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score = 1472 bits (3810), Expect = 0.0
 Identities = 744/753 (98%), Positives = 744/753 (98%), Gaps = 9/753 (1%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480
           HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480

Query: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540
           ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
Sbjct: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540

Query: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600
           THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
Sbjct: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600

Query: 601 STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 660
           STNLFSKLTSKLTR         RLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF
Sbjct: 601 STNLFSKLTSKLTR---------RLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 651

Query: 661 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 720
           TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
Sbjct: 652 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 711

Query: 721 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 712 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 744


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score = 1434 bits (3713), Expect = 0.0
 Identities = 729/753 (96%), Positives = 729/753 (96%), Gaps = 24/753 (3%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD
Sbjct: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480
           HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
Sbjct: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480

Query: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540
           ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
Sbjct: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540

Query: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600
           THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
Sbjct: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600

Query: 601 STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 660
           STNLFSKLTSKLTR                        SRNVSAEQKDENKEAKPRSLRF
Sbjct: 601 STNLFSKLTSKLTR------------------------SRNVSAEQKDENKEAKPRSLRF 636

Query: 661 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 720
           TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
Sbjct: 637 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 696

Query: 721 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 697 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 729


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score = 1397 bits (3615), Expect = 0.0
 Identities = 713/753 (94%), Positives = 713/753 (94%), Gaps = 40/753 (5%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ
Sbjct: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT
Sbjct: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLGRKSSE                VRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD
Sbjct: 361 YLLLGRKSSE----------------VRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 404

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 480
           HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK
Sbjct: 405 HAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNK 464

Query: 481 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 540
           ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS
Sbjct: 465 ADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVAS 524

Query: 541 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 600
           THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG
Sbjct: 525 THSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRG 584

Query: 601 STNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRF 660
           STNLFSKLTSKLTR                        SRNVSAEQKDENKEAKPRSLRF
Sbjct: 585 STNLFSKLTSKLTR------------------------SRNVSAEQKDENKEAKPRSLRF 620

Query: 661 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 720
           TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL
Sbjct: 621 TWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKL 680

Query: 721 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           PRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 681 PRLSLNGVRFKRISGTSIAFKNIASKIANELKL 713


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score = 1035 bits (2677), Expect = 0.0
 Identities = 564/822 (68%), Positives = 630/822 (76%), Gaps = 96/822 (11%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGAR-----CRNSIASCADEQPHIGN 55
           MS RTPLPTVNERDTENHTS  DG  E   + ++S +R     CRNSI S  DEQPHIGN
Sbjct: 1   MSARTPLPTVNERDTENHTSV-DGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGN 59

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           YRL KTIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNPTSLQKLFREVRIMKILNHPNI
Sbjct: 60  YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
           VKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IV
Sbjct: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIV 179

Query: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVD 235
           HRDLKAENLLLD DMNIKIADFGFSNEFTVG KLDTFCGSPPYAAPELFQGKKYDGPEVD
Sbjct: 180 HRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD 239

Query: 236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR 295
           VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+ LVLNPIKR
Sbjct: 240 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR 299

Query: 296 GTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYD 355
           G+LEQIMKDRW+N GHEE+ELKP+ EP+ D +D KRIDIMV MG++++EI ++L   KYD
Sbjct: 300 GSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYD 359

Query: 356 EITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHH-KVQRSVFSSQK 414
           E+ ATY+LLGRK  E +  +S SS NL   + RPSSDLNNST QSP H KVQRS+ ++QK
Sbjct: 360 EVMATYILLGRKPPEFEGGESLSSGNL-CQRSRPSSDLNNSTLQSPAHLKVQRSISANQK 418

Query: 415 QRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKE--DGISSRKSSGSAVGGKGIAPASPML 472
           QRR+SDHAGP+IP  V+Y KR Q ++ +S+ KE  D   +RK   + VG K    ASP++
Sbjct: 419 QRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLV 478

Query: 473 GNASNPNKADIPERKKSSTVPSSNTASGG-MTRRNTYVCSERTTADRHSVIQNGKENS-- 529
           G          PERKKSST+PS+N  SGG M RRNTYVC ERTT DR+  +QNGK++S  
Sbjct: 479 G----------PERKKSSTIPSNNVYSGGSMARRNTYVC-ERTT-DRYVALQNGKDSSLT 526

Query: 530 -----------------------------------------TIPD----------QRTPV 538
                                                    TI D          QR P 
Sbjct: 527 EMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPA 586

Query: 539 A--STHSISSAATPDRIRFPRGTASRSTFHG-QPRERRTATYNGPPASPSLSHEATPLSQ 595
           A  S HSIS+ ATPDR RFPRG++SRSTFHG Q RERR+  YNGPPASP  SHE    + 
Sbjct: 587 ASPSAHSIST-ATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASP--SHETGAFAH 643

Query: 596 TRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAE----QKDENK 651
            R   ST + SK+TSK         F++R P+E E +GR + +SR+ S E     K+E K
Sbjct: 644 ARRGTSTGIISKITSK---------FVRRDPSEGEASGRTD-TSRSTSGEPKERDKEEGK 693

Query: 652 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLV 711
           ++KPRSLRFTWSMKTTSSMDP DMMREIRKVLDANNCDYEQ+ERFLLFCVHGD   ++LV
Sbjct: 694 DSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLV 753

Query: 712 QWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           QWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Sbjct: 754 QWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 795


>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
           [Homo sapiens]
          Length = 659

 Score =  942 bits (2436), Expect = 0.0
 Identities = 481/498 (96%), Positives = 483/498 (96%), Gaps = 15/498 (3%)

Query: 256 QNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 315
           ++LKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE
Sbjct: 177 RDLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 236

Query: 316 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 375
           LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD
Sbjct: 237 LKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASD 296

Query: 376 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 435
           SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR
Sbjct: 297 SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKR 356

Query: 436 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 495
           SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS
Sbjct: 357 SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSS 416

Query: 496 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 555
           NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF
Sbjct: 417 NTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRF 476

Query: 556 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 615
           PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR
Sbjct: 477 PRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 536

Query: 616 NMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 675
           NMSFRFIK               SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM
Sbjct: 537 NMSFRFIK---------------SRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDM 581

Query: 676 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 735
           MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG
Sbjct: 582 MREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISG 641

Query: 736 TSIAFKNIASKIANELKL 753
           TSIAFKNIASKIANELKL
Sbjct: 642 TSIAFKNIASKIANELKL 659



 Score =  360 bits (924), Expect = 3e-99
 Identities = 180/180 (100%), Positives = 180/180 (100%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK
Sbjct: 1   MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE
Sbjct: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  920 bits (2378), Expect = 0.0
 Identities = 511/763 (66%), Positives = 584/763 (76%), Gaps = 57/763 (7%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410

Query: 421 H-AGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNP 478
             AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G     
Sbjct: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG----- 460

Query: 479 NKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTP 537
                 ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR P
Sbjct: 461 -----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVP 512

Query: 538 VA--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEA 590
           VA  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H  
Sbjct: 513 VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-- 569

Query: 591 TPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDEN 650
              SQ R   S ++FSK TSK  RRN+SFRF +R            GS  N   ++K+E 
Sbjct: 570 ---SQGRRGASGSIFSKFTSKFVRRNLSFRFARR--------PHVVGSGGN--DKEKEEF 616

Query: 651 KEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENL 710
           +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ 
Sbjct: 617 REAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDF 676

Query: 711 VQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 677 VQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 719


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  915 bits (2364), Expect = 0.0
 Identities = 508/767 (66%), Positives = 583/767 (76%), Gaps = 60/767 (7%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN 479
            AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G      
Sbjct: 411 QAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG------ 459

Query: 480 KADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPV 538
                ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PV
Sbjct: 460 ----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPV 512

Query: 539 A--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591
           A  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 568

Query: 592 PLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNV-----SAEQ 646
             SQ R   S ++FSK TSK  RRN++         E E   R E    +V     + ++
Sbjct: 569 --SQGRRGASGSIFSKFTSKFVRRNLN---------EPESKDRVETLRPHVVGSGGNDKE 617

Query: 647 KDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGH 706
           K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG   
Sbjct: 618 KEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPG 677

Query: 707 AENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
            E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 678 HEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 724


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  909 bits (2349), Expect = 0.0
 Identities = 512/820 (62%), Positives = 589/820 (71%), Gaps = 102/820 (12%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410

Query: 421 HA-GPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNP 478
            A GPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G     
Sbjct: 411 QAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPGL---- 461

Query: 479 NKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPD---- 533
                 ERKK++  PS+N+     T R+      ER +  + S IQNGK++ T+P     
Sbjct: 462 ------ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKDSLTMPGSRAS 514

Query: 534 ------------------------------------------------QRTPVAS--THS 543
                                                           QR PVAS   H+
Sbjct: 515 TASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHN 574

Query: 544 ISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEATPLSQTRS 598
           ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H     SQ R 
Sbjct: 575 ISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH-----SQGRR 628

Query: 599 RGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNV-----SAEQKDENKEA 653
             S ++FSK TSK  RRN+SFRF +R   E E   R E    +V     + ++K+E +EA
Sbjct: 629 GASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREA 688

Query: 654 KPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQW 713
           KPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ VQW
Sbjct: 689 KPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQW 748

Query: 714 EMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           EMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 749 EMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 788


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  908 bits (2346), Expect = 0.0
 Identities = 505/762 (66%), Positives = 576/762 (75%), Gaps = 65/762 (8%)

Query: 2   STRTPLPTVNERDTENHT-SHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLK 60
           S RTPLPT+NERDTE  T  H D +    S   R     RNS A+ ADEQPHIGNYRLLK
Sbjct: 3   SARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRG----RNS-ATSADEQPHIGNYRLLK 57

Query: 61  TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
           TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SLQKLFREVRIMK+LNHPNIVKLFE
Sbjct: 58  TIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117

Query: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
           VIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+KFRQIVSAVQYCHQK IVHRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 181 AENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 240
           AENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLG 237

Query: 241 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQ 300
           VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK+FL+LNP KRGTLEQ
Sbjct: 238 VILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297

Query: 301 IMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITAT 360
           IMKDRW+N GHE+DELKP+VEP  D  D +R ++MV MGY++EEIQ+SL   +Y+E+ AT
Sbjct: 298 IMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMAT 357

Query: 361 YLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSD 420
           YLLLG KSSEL+    +        K RPS+DL NS+  SP HKVQRSV ++ KQRR+SD
Sbjct: 358 YLLLGYKSSELEGDTIT-------LKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSD 410

Query: 421 HAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSSGSAVGGKGIAPASPMLGNASNPN 479
            AGPAIP+  +Y K++Q++ A++   +ED  S RK+S +A       PASP+ G      
Sbjct: 411 QAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAK-----VPASPLPG------ 459

Query: 480 KADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTTADRHSVIQNGKENSTIPDQRTPV 538
                ERKK++  PS+N+     T R+      ER +  + S IQNGK+ ST P QR PV
Sbjct: 460 ----LERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQAS-IQNGKD-STAP-QRVPV 512

Query: 539 A--STHSISSA-ATPDRIRFPRGTASRSTFHG----QPRERRTATYNGPPASPSLSHEAT 591
           A  S H+ISS+   PDR  FPRG +SRSTFH     Q R+++   Y   PASPS  H   
Sbjct: 513 ASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPS-GH--- 568

Query: 592 PLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENK 651
             SQ R   S ++FSK TSK  RR                     GS  N   ++K+E +
Sbjct: 569 --SQGRRGASGSIFSKFTSKFVRR-----------------PHVVGSGGN--DKEKEEFR 607

Query: 652 EAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLV 711
           EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E  E+++L C+HG    E+ V
Sbjct: 608 EAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFV 667

Query: 712 QWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
           QWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANELKL
Sbjct: 668 QWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 709


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  876 bits (2263), Expect = 0.0
 Identities = 490/782 (62%), Positives = 565/782 (72%), Gaps = 105/782 (13%)

Query: 38  RCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL 97
           R RNS A+ ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN +SL
Sbjct: 3   RGRNS-ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61

Query: 98  QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARS 157
           QKLFREVRIMK+LNHPNIVKLFEVIETEKTLYL+MEYASGGEVFDYLVAHGRMKEKEAR+
Sbjct: 62  QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121

Query: 158 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217
           KFRQIVSAVQYCHQK IVHRDLKAENLLLDADMNIKIADFGFSNEFT G KLDTFCGSPP
Sbjct: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181

Query: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
           YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS
Sbjct: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241

Query: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVG 337
           TDCENLLK+FL+LNP KRGTLEQIMKDRW+N GHE+DELKP+VEP  D  D +R ++MV 
Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301

Query: 338 MGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNST 397
           MGY++EEIQ+SL   +Y+E+ ATYLLLG KSSEL+    +        K RPS+DL NS+
Sbjct: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTIT-------LKPRPSADLTNSS 354

Query: 398 GQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDL-KEDGISSRKSS 456
             SP HKVQRSV ++ KQRR+SD AGPAIP+  +Y K++Q++ A++   +ED  S RK+S
Sbjct: 355 APSPSHKVQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS 414

Query: 457 GSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRN-TYVCSERTT 515
            +A       PASP+ G           ERKK++  PS+N+     T R+      ER +
Sbjct: 415 STAK-----VPASPLPGL----------ERKKTTPTPSTNSVLSTSTNRSRNSPLLERAS 459

Query: 516 ADRHSVIQNGKENSTIPD------------------------------------------ 533
             + S IQNGK++ T+P                                           
Sbjct: 460 LGQAS-IQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESN 518

Query: 534 ----------QRTPVAS--THSISSAA-TPDRIRFPRGTASRSTFHG----QPRERRTAT 576
                     QR PVAS   H+ISS+   PDR  FPRG +SRSTFH     Q R+++   
Sbjct: 519 CEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLP 578

Query: 577 YNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYE 636
           Y   PASPS  H     SQ R   S ++FSK TSK  RRN++         E E   R E
Sbjct: 579 YGVTPASPS-GH-----SQGRRGASGSIFSKFTSKFVRRNLN---------EPESKDRVE 623

Query: 637 GSSRNV-----SAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYE 691
               +V     + ++K+E +EAKPRSLRFTWSMKTTSSM+P +MMREIRKVLDAN+C  E
Sbjct: 624 TLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSE 683

Query: 692 QRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANEL 751
             E+++L C+HG    E+ VQWEMEVCKLPRLSLNGVRFKRISGTS+AFKNIASKIANEL
Sbjct: 684 LHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANEL 743

Query: 752 KL 753
           KL
Sbjct: 744 KL 745


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  807 bits (2084), Expect = 0.0
 Identities = 429/632 (67%), Positives = 499/632 (78%), Gaps = 23/632 (3%)

Query: 1   MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
           MS+RT L   N+R+++ H + G GR   +  S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1   MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60

Query: 58  LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
           LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 61  LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120

Query: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
           LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180

Query: 178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
           DLKAENLLLDA+ NIKIADFGFSNEFT+G KLDTFCGSPPYAAPELFQGKKYDGPEVD+W
Sbjct: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240

Query: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
           SLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR T
Sbjct: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300

Query: 298 LEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
           LEQIMKD+WIN G+E +ELKP+ EPE D  D KRI++MVGMGY++EEI+ESL+  KY+E+
Sbjct: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360

Query: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-Q 413
           TATYLLLGRK+ E        +  L+LA+VR  SD  N T  S    H K QRS  S+  
Sbjct: 361 TATYLLLGRKTEE---GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417

Query: 414 KQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPM 471
           +QRR+SD  GP+      +PKRS TST +++LKE+ +  RK+S S    G +G+ P+SPM
Sbjct: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPM 475

Query: 472 LGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531
           + +A NPNKA+IPER+K ST   +N     MTRRNTYVC+ER  A+R S++ NGKENS+ 
Sbjct: 476 VSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS- 534

Query: 532 PDQRTPVASTHSISSA-ATPDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPAS 583
              R P AS  S S A  + +R R  RG+  RSTFH GQ R+RR          NGPPAS
Sbjct: 535 GTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPAS 594

Query: 584 PSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 615
           P+L+HEA PL   R R +TNLF+KLTSKLTRR
Sbjct: 595 PTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRR 626


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  381 bits (978), Expect = e-105
 Identities = 186/320 (58%), Positives = 245/320 (76%), Gaps = 8/320 (2%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           IG Y + +TIGKGNFA VK A H++T  +VAIKIIDKTQL+  +L+K+FREV+IMK+L H
Sbjct: 5   IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 65  PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124

Query: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
            IVHRDLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184

Query: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
           +VD+WSLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST+CE+L++  LVL+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244

Query: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID--------IMVGMGYSQEE 344
            KR ++EQI K +W+  G  +      +     + +++++D         M  MG  +E+
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304

Query: 345 IQESLSKMKYDEITATYLLL 364
             +SL    YD  +A Y LL
Sbjct: 305 TLQSLRSDAYDHYSAIYSLL 324


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  354 bits (908), Expect = 2e-97
 Identities = 174/317 (54%), Positives = 235/317 (74%), Gaps = 5/317 (1%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           +G Y +  T+GKGNFA VKL RH +T  EVAIKIIDK+QL+  +L+K++REV+IMK+L+H
Sbjct: 17  VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I+KL++V+ET+  LYL+ EYA  GE+FDYL  HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77  PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136

Query: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
           +IVHRDLKAENLLLD +MNIKIADFGF N F  G  L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196

Query: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
           ++D+WS+GV+LY LV G+LPFDG  L  LR+RVL G++RIP++MS DCE+L++R LVL+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256

Query: 293 IKRGTLEQIMKDRW--INAGHEEDELKPFV---EPELDISDQKRIDIMVGMGYSQEEIQE 347
            KR T+ QI + +W  I    +   L P     EP +   +++ + +M  +G  Q++  E
Sbjct: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316

Query: 348 SLSKMKYDEITATYLLL 364
           SL    Y+   A Y LL
Sbjct: 317 SLQNKSYNHFAAIYFLL 333


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  350 bits (899), Expect = 2e-96
 Identities = 172/327 (52%), Positives = 237/327 (72%), Gaps = 12/327 (3%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           +G Y + +T+GKGNFA VKLARH +T  +VAIKIIDKT+L+ ++L+K++REV++MK+LNH
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           P+I+KL++V+ET+  LY++ E+A  GE+FDYL ++G + E EAR KF QI+SAV+YCH  
Sbjct: 84  PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143

Query: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
            IVHRDLK ENLLLD +M+IK+ADFGF N +  G  L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203

Query: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
           ++D+WSLGV+LY LV GSLPFDG NL  LR+RVL G++RIPF+MS DCE+L++R LV++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263

Query: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEP---------ELDISDQKRIDIMVGMGYSQE 343
            +R T+ QI + RW+ A   E  L     P          L   D++ + IM  +G  ++
Sbjct: 264 ARRITIAQIRQHRWMRA---EPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320

Query: 344 EIQESLSKMKYDEITATYLLLGRKSSE 370
              ESL    Y+   A Y LL  +  E
Sbjct: 321 RTVESLQNSSYNHFAAIYYLLLERLKE 347


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  286 bits (733), Expect = 4e-77
 Identities = 204/588 (34%), Positives = 300/588 (51%), Gaps = 64/588 (10%)

Query: 52  HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN 111
           ++G YRL KT+GKG    VKL  H +TG++VAIKI+++ +L+ + L K+ RE+ I+K++ 
Sbjct: 30  YVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIE 89

Query: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171
           HP+++KL +V E +K LYL++E+ SGGE+FDYLV  GR+  KEAR  FRQIVSA+ +CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
             I HRDLK ENLLLD   NI+IADFG ++       L+T CGSP YA PE+ +G+KYDG
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
              D+WS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+  + + 
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 292 PIKRGTLEQIMKDRWINAG-HEEDELKPFVEP---------------ELDISDQKRIDIM 335
           P KR +LEQI K  W   G HE D   P +EP               ELD  D       
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPD---PCLEPAPGRRVAMRSLPSNGELD-PDVLESMAS 325

Query: 336 VGMGYSQEEIQESL-SKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLN 394
           +G    +E +   L S+ +  E    YLLL RK       D           + P +D++
Sbjct: 326 LGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQD---------LPPRNDVD 376

Query: 395 NSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS-DLKEDGISSR 453
                 P  +V   + S   +RR    +   +    A    S   T  + ++ +    SR
Sbjct: 377 -----PPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSR 431

Query: 454 KSSGSAVGGKG---IAPASPMLGNASNPNKADIPE-----RKKSSTVPSSNTASGGM--- 502
             SG++ G       +P SP+   +  P   D          K+ T+PS     GG    
Sbjct: 432 SVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQ 491

Query: 503 ----TRRNTYV----CSERTTADR--HSVIQNGKENST-IPDQRTPVASTHSISSAATPD 551
               + R+T +     S R++     HS +   + + T  P    P +    +  AA   
Sbjct: 492 PPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRS 551

Query: 552 RIRFPRGTASRSTFHGQPR-ERRTATYNGPPASPSLSHEATPLSQTRS 598
           R+      + R++F G PR  RR           SL+ E++P    RS
Sbjct: 552 RL-----NSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRS 594


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  281 bits (720), Expect = 1e-75
 Identities = 167/454 (36%), Positives = 253/454 (55%), Gaps = 31/454 (6%)

Query: 47  ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 106
           A    ++G YRL KT+GKG    VKL  H +T ++VAIKI+++ +L+ + L K+ RE+ I
Sbjct: 10  AQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 69

Query: 107 MKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAV 166
           +K++ HP+++KL +V E +K LYL++E+ SGGE+FDYLV  GR+  KEAR  FRQI+SA+
Sbjct: 70  LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129

Query: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQG 226
            +CH   I HRDLK ENLLLD   NI+IADFG ++       L+T CGSP YA PE+ +G
Sbjct: 130 DFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189

Query: 227 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKR 286
           +KYDG + DVWS GVIL+ L+ G+LPFD  NL++L E+V RG + +P ++  DC++LL+ 
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249

Query: 287 FLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE--------PELDISDQKRIDIMVGM 338
            + ++  +R TLE I K  W   G  E E +  +         P L+  D   +D M  +
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSL 309

Query: 339 GYSQEE---IQESLSKMKYDEITATYLLLGRKS--SELDASDSSSSSNLSLAKVRPSSDL 393
           G  ++    +Q+ LS+ +  E    +LLL RK      +  D    + +   + R  S +
Sbjct: 310 GCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPM 369

Query: 394 NNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSR 453
            N  G+    +    V S           G  +P+  A            ++ + G  SR
Sbjct: 370 LNRHGKRRPERKSMEVLS-------VTDGGSPVPARRAI-----------EMAQHGQRSR 411

Query: 454 KSSGSAVGGKGIAPASPMLGNASNPNKADIPERK 487
             SG++ G      +SP +    +P  + +P  K
Sbjct: 412 SISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPK 445


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  278 bits (712), Expect = 1e-74
 Identities = 212/708 (29%), Positives = 339/708 (47%), Gaps = 77/708 (10%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
           Y L +TIG G FAKVKLA HILTG  VAIKI+DK  L  + L ++  E+  +K L H +I
Sbjct: 11  YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69

Query: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIV 175
            +L+ V+ET   +++++EY  GGE+FDY+++  R+ E+E R  FRQIVSAV Y H +   
Sbjct: 70  CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129

Query: 176 HRDLKAENLLLDADMNIKIADFGFSNEFTVGGK---LDTFCGSPPYAAPELFQGKKYDGP 232
           HRDLK ENLL D    +K+ DFG   +   G K   L T CGS  YAAPEL QGK Y G 
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188

Query: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
           E DVWS+G++LY L+ G LPFD  N+  L ++++RGKY +P ++S     LL++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248

Query: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKM 352
            KR +++ ++   WI   +          P + + D    ++ V    +++ +++ +S  
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLW 308

Query: 353 KYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFS 411
           +YD +TATY LLL +K+         SS +   A   P +D+ ++               
Sbjct: 309 QYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNW------------- 355

Query: 412 SQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISS-----RKSSGSAVGGKGIA 466
                        ++  V A  K       D D  ED +S+     R S  +    +   
Sbjct: 356 -------------SLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNG 402

Query: 467 PASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGK 526
             S  L  A     A+  + K++   P S      +     ++  E  T    +  Q+ +
Sbjct: 403 VESKSLTPALCRTPANKLKNKENVYTPKS-----AVKNEEYFMFPEPKTPVNKN--QHKR 455

Query: 527 ENSTIPDQRTPVASTHSISSAATPDRIRF-PRGTASRSTFHGQPRERRTATYNGPPASPS 585
           E  T P++ T  +   +     TP +I     GT    T    P ERR         S  
Sbjct: 456 EILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISP-ERRC-------RSVE 507

Query: 586 LSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAE 645
           L      + +T  R    +F  L           R + ++ T   R+ R +GS+R+    
Sbjct: 508 LDLNQAHMEETPKRKGAKVFGSLE----------RGLDKVITVLTRSKR-KGSARD---- 552

Query: 646 QKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDG 705
                    PR L+  +++ TT  ++P  ++ EI  +L   + D+ Q+  + L C     
Sbjct: 553 --------GPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQK-GYTLKCQTQSD 603

Query: 706 HAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 753
             +  +Q+E+EVC+L +  + G+R +R+ G +  +K +   I +  K+
Sbjct: 604 FGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV 651


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  269 bits (688), Expect = 6e-72
 Identities = 155/403 (38%), Positives = 232/403 (57%), Gaps = 20/403 (4%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121

Query: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181

Query: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241

Query: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 334
             LL   L ++P+KR T++ I +  W      + +L  ++ PE    D   ID      +
Sbjct: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296

Query: 335 MVGMGYSQEEIQESL-SKMKYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392
                 ++ E+  SL S    D++   Y L++  +     AS+   +S+         S 
Sbjct: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSA 356

Query: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 434
           ++   G  PH  ++   +  S K R   D      P  +A  K
Sbjct: 357 MHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKK 399


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  268 bits (685), Expect = 1e-71
 Identities = 148/350 (42%), Positives = 218/350 (62%), Gaps = 14/350 (4%)

Query: 54  GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
           G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+  +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
           NIV+L+EVI+T+  LYLI+E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ R L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
           P +R +LE+I    W+         K   P V  + ++S+++   I    ++G    ++ 
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312

Query: 345 IQESLSKMKYDEITATYLLLG----RKSSELDASDSSSSSNLSLAKVRPS 390
           I E+L   +Y+ ITATY LL     R+  E +    S+S +   A+ R S
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  268 bits (685), Expect = 1e-71
 Identities = 148/350 (42%), Positives = 218/350 (62%), Gaps = 14/350 (4%)

Query: 54  GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
           G Y L KT+G+G+FA VKLARH+ TG +VA+K+IDKT+L+  +   LF+EVR MK++ HP
Sbjct: 14  GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

Query: 114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCHQK 172
           NIV+L+EVI+T+  LYLI+E   GG++FDY++ H   + E  A+  F QIV A+ YCH+ 
Sbjct: 74  NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133

Query: 173 RIVHRDLKAENLL-LDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
            +VHRDLK EN++  +    +K+ DFGFSN+F  G KL T CGS  Y+APE+  G +YD 
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193

Query: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291
           P VD+WSLGVIL+ LV G  PF   N  E    ++  KY +P ++S +C++L+ R L  +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253

Query: 292 PIKRGTLEQIMKDRWINAGHEEDELK---PFVEPELDISDQKRIDI----MVGMGYSQEE 344
           P +R +LE+I    W+         K   P V  + ++S+++   I    ++G    ++ 
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYK-NLSEEEHNSIIQRMVLGDIADRDA 312

Query: 345 IQESLSKMKYDEITATYLLLG----RKSSELDASDSSSSSNLSLAKVRPS 390
           I E+L   +Y+ ITATY LL     R+  E +    S+S +   A+ R S
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQS 362


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  266 bits (679), Expect = 7e-71
 Identities = 151/393 (38%), Positives = 230/393 (58%), Gaps = 26/393 (6%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR+ EKE+R  F+
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132

Query: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220
           QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192

Query: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++  G +  P Y++   
Sbjct: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252

Query: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE------LDISDQKRIDI 334
            +LLK  L ++P+KR T++ I +  W      + +L  ++ PE        I D+   ++
Sbjct: 253 ISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDPSYSSTMIDDEALKEV 307

Query: 335 MVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392
                 S+EE+   L    + +    A +L++  +    +A D        LA   P S 
Sbjct: 308 CEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD------FYLATSPPDSF 361

Query: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424
           L++     PH  +V   V  + + R   D   P
Sbjct: 362 LDDHHLTRPHPERVPFLVAETPRARHTLDELNP 394


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  261 bits (666), Expect = 2e-69
 Identities = 179/554 (32%), Positives = 270/554 (48%), Gaps = 58/554 (10%)

Query: 8   PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNF 67
           P   +R      + G  R+ V   T+    R  + +     +      Y L +T+GKG +
Sbjct: 7   PVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTY 66

Query: 68  AKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFEVIETEK 126
            KVK A    +GR VAIK I K ++ +   +  + RE+ IM  LNHP+I+ ++EV E + 
Sbjct: 67  GKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKD 126

Query: 127 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 186
            + +IMEYAS GE++DY+    R+ E+E R  FRQIVSAV YCH+  +VHRDLK EN+LL
Sbjct: 127 KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILL 186

Query: 187 DADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 246
           D + NIKIADFG SN +     L TFCGSP YA+PE+  G+ Y GPEVD W+LGV+LYTL
Sbjct: 187 DDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTL 246

Query: 247 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW 306
           V G++PFDG + K L  ++  G+YR P   S D   L++  L++NP +R T+E I    W
Sbjct: 247 VYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWW 305

Query: 307 INAGHE---------EDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
           +N G++          D   P +   +D   +       G+    E   + L+K    E+
Sbjct: 306 VNWGYKSSVCDCDALHDSESPLLARIIDWHHRS-----TGLQADTEAKMKGLAKPTTSEV 360

Query: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRR 417
               +L  ++S +    ++  + +   A     S L++   +    K   S   S     
Sbjct: 361 ----MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGF 416

Query: 418 YSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASN 477
                GPA+PS         T   + DL   G+              + P+SP       
Sbjct: 417 IEGVVGPALPS---------TFKMEQDLCRTGV--------------LLPSSP------- 446

Query: 478 PNKADIPER---KKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 534
             +A++P +   K+S+T+P          R + Y  S   +     +  N    S+IP  
Sbjct: 447 --EAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSP 504

Query: 535 RTP---VASTHSIS 545
             P     ++HS+S
Sbjct: 505 SPPDPARVTSHSLS 518


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  256 bits (655), Expect = 4e-68
 Identities = 132/257 (51%), Positives = 175/257 (68%), Gaps = 3/257 (1%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114
           Y  L+T+GKG + KVK AR   +GR VAIK I K ++ +   L  + RE+ IM  LNHP+
Sbjct: 53  YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111

Query: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174
           I+ + EV E    + ++MEYAS G+++DY+    ++ E+EAR  FRQIVSAV YCHQ R+
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171

Query: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 234
           VHRDLK EN+LLDA+ NIKIADFG SN +  G  L TFCGSP YA+PE+  GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231

Query: 235 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294
           D WSLGV+LY LV G++PFDG + K L +++  G YR P   S  C  L++  L++NP +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290

Query: 295 RGTLEQIMKDRWINAGH 311
           R TLE +    W+N G+
Sbjct: 291 RATLEDVASHWWVNWGY 307


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  256 bits (653), Expect = 7e-68
 Identities = 151/408 (37%), Positives = 230/408 (56%), Gaps = 41/408 (10%)

Query: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100
           A++Q H     IG+Y L  T+G G F KVK+ +H LTG +VA+KI+++ ++    +  K+
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR----------- 149
            RE++ +K+  HP+I+KL++VI T   ++++MEY SGGE+FDY+  +GR           
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132

Query: 150 ----MKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTV 205
               + EKE+R  F+QI+S V YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + 
Sbjct: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192

Query: 206 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 265
           G  L T CGSP YAAPE+  G+ Y GPEVD+WS GVILY L+ G+LPFD  ++  L +++
Sbjct: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252

Query: 266 LRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-- 323
             G +  P Y++    +LLK  L ++P+KR T++ I +  W      + +L  ++ PE  
Sbjct: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF-----KQDLPKYLFPEDP 307

Query: 324 ----LDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE--ITATYLLLGRKSSELDASDSS 377
                 I D+   ++      S+EE+   L    + +    A +L++  +    +A D  
Sbjct: 308 SYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKD-- 365

Query: 378 SSSNLSLAKVRPSSDLNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGP 424
                 LA   P S L++     PH  +V   V  + + R   D   P
Sbjct: 366 ----FYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP 409


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  256 bits (653), Expect = 7e-68
 Identities = 131/332 (39%), Positives = 205/332 (61%), Gaps = 8/332 (2%)

Query: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
           IG YR+   IG GNF++VKL  H LT  +VAIKI+DKT+L+  + + L RE+  M+ L+H
Sbjct: 71  IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130

Query: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
           PNI++L+EV+ET   L+L+MEYA GGE+F  +   G++ E E++  F QIVSAV++ H+ 
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190

Query: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
           +I+HRDLKAEN+   ++  +K+ DFGFS     G  L+TFCGSPPYAAPELF+ + Y G 
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250

Query: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
            VD+W+LGV+LY +V+G++PF  + + +L++ +L G Y +P ++S  C  L++  L   P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310

Query: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRI--------DIMVGMGYSQEE 344
            +R  ++ IM D W+        L+PF      +S+   +          +  +G ++E 
Sbjct: 311 TERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEEH 370

Query: 345 IQESLSKMKYDEITATYLLLGRKSSELDASDS 376
           I+ +  +     IT  Y ++  +     A +S
Sbjct: 371 IRNNQGRDARSSITGVYRIILHRVQRKKALES 402


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  222 bits (566), Expect = 9e-58
 Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)

Query: 48  DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
           D Q H  +GNY +  + +G+G+FAKV+   H+LTG +VAIK+IDK +    +   + L R
Sbjct: 51  DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110

Query: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
           E +I +++ HPNI +L +++ETE + YL+ME   GG +   +    R++E EAR   RQ+
Sbjct: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170

Query: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219
           +SAV++ H+  +VHRDLK ENLLLD D NIK+ DFG SN   + G  D F   CGSP YA
Sbjct: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230

Query: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276
           APEL   KKY GP++DVWS+GV +Y +++G+LPF  +  +L+ L ++++  +   +P  +
Sbjct: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289

Query: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332
           ST   + L+  L  +P+KR  ++Q + +RW+N  +          P      D+S    +
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349

Query: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376
            +   +GY   ++  ++   +   I A Y LL +K     S + D  DS
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  189 bits (479), Expect = 1e-47
 Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
           Y L   +G+G++AKVK A        VAIKIID+ +     L+K   RE+ I+ +LNH +
Sbjct: 12  YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71

Query: 115 IVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
           I+K +E+ ET    +Y++ME A  G++ + +   G + E EAR KF Q+  A++YCH   
Sbjct: 72  IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131

Query: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKK 228
           +VHRDLK +NLLLD D NIK++DF FS        G++    TFCGSP YAAPE+ QG  
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191

Query: 229 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 284
           Y     D+WSLGVILY +V GS+P+D  N+K++    ++ ++R+ F    +++ +C++L+
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249

Query: 285 KRFLVLNPIKRGTLEQIMKDRWI 307
              L  +  +R  +++I+   W+
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272


>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
          Length = 268

 Score =  188 bits (477), Expect = 2e-47
 Identities = 103/257 (40%), Positives = 163/257 (63%), Gaps = 6/257 (2%)

Query: 56  YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
           Y+L KTIG+G ++KVK A      R+VAIK+IDK       +Q+   RE++I++ L+H N
Sbjct: 10  YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69

Query: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
           I++++E++E+ +  + L+ME A GG+VFD ++  G + E  A++ FRQ+V A++YCH   
Sbjct: 70  IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129

Query: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK--LDTFCGSPPYAAPELFQGKKYDG 231
           + HRDLK EN LL    N+K+ DFGF+       +    TFCGS  YAAPE+ QG  +D 
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188

Query: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
            + DVWS+GV+LY ++  SLPFD  ++ ++  +  +G  +     +S DC++LLKR L  
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248

Query: 291 NPIKRGTLEQIMKDRWI 307
           + I R ++E++    W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265


>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
          Length = 358

 Score =  184 bits (467), Expect = 3e-46
 Identities = 103/258 (39%), Positives = 160/258 (62%), Gaps = 15/258 (5%)

Query: 62  IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF--REVRIMKILNHPNIVKLF 119
           +GKG++AKVK A        VA+KIID+ +  PT   + F  RE+ I+  +NH +I+K +
Sbjct: 18  LGKGSYAKVKSAYSERLKFNVAVKIIDRKK-TPTDFVERFLPREMDILATVNHGSIIKTY 76

Query: 120 EVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
           E+ ET +  +Y+IME    G++ +++   G + E  AR  FRQ+ SAV+YCH   IVHRD
Sbjct: 77  EIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRD 136

Query: 179 LKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKKYDGPE 233
           LK ENLLLD D NIK++DFGFS        G++    TFCGS  YAAPE+ Q   Y    
Sbjct: 137 LKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKV 196

Query: 234 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLLKRFLV 289
            D+WSLGVILY +V GS+P+D  +++++    ++ ++R+ F     ++ +C++L+ R L 
Sbjct: 197 YDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQ 254

Query: 290 LNPIKRGTLEQIMKDRWI 307
            +  +R  +++I+   W+
Sbjct: 255 PDVSQRLHIDEILSHSWL 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,992,388
Number of Sequences: 37866
Number of extensions: 1278246
Number of successful extensions: 6789
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 745
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 3563
Number of HSP's gapped (non-prelim): 1516
length of query: 753
length of database: 18,247,518
effective HSP length: 110
effective length of query: 643
effective length of database: 14,082,258
effective search space: 9054891894
effective search space used: 9054891894
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.