Search of human proteins with 189011550

Search of human proteins with 189011550

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189011550 N-acylsphingosine amidohydrolase 1 isoform c [Homo
sapiens]
         (389 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189011550 N-acylsphingosine amidohydrolase 1 isoform c [Homo ...   811   0.0  
gi|189011546 N-acylsphingosine amidohydrolase 1 isoform b [Homo ...   776   0.0  
gi|189011548 N-acylsphingosine amidohydrolase 1 isoform a prepro...   693   0.0  
gi|109148550 N-acylethanolamine acid amidase isoform 1 precursor...   183   2e-46
gi|109148548 N-acylethanolamine acid amidase isoform 2 precursor...   163   3e-40
gi|4559408 colony stimulating factor 2 receptor, beta precursor ...    29   8.3  
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]         29   8.3  

>gi|189011550 N-acylsphingosine amidohydrolase 1 isoform c [Homo
           sapiens]
          Length = 389

 Score =  811 bits (2095), Expect = 0.0
 Identities = 389/389 (100%), Positives = 389/389 (100%)

Query: 1   MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTVF 60
           MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTVF
Sbjct: 1   MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTVF 60

Query: 61  PAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIP 120
           PAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIP
Sbjct: 61  PAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPVPGLLGNFPGPFEEEMKGIAAVTDIP 120

Query: 121 LGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLT 180
           LGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLT
Sbjct: 121 LGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLT 180

Query: 181 VNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV 240
           VNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV
Sbjct: 181 VNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV 240

Query: 241 MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYE 300
           MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYE
Sbjct: 241 MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYE 300

Query: 301 LDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNK 360
           LDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNK
Sbjct: 301 LDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNK 360

Query: 361 LTVYTTLIDVTKGQFETYLRDCPDPCIGW 389
           LTVYTTLIDVTKGQFETYLRDCPDPCIGW
Sbjct: 361 LTVYTTLIDVTKGQFETYLRDCPDPCIGW 389


>gi|189011546 N-acylsphingosine amidohydrolase 1 isoform b [Homo
           sapiens]
          Length = 411

 Score =  776 bits (2003), Expect = 0.0
 Identities = 382/418 (91%), Positives = 382/418 (91%), Gaps = 36/418 (8%)

Query: 1   MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTVF 60
           MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPT  
Sbjct: 1   MNCCIGLGEKARGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPT-- 58

Query: 61  PAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPV------------------------- 95
                YRGAVPWYTINLDLPPYKRWHELMLDKAPV                         
Sbjct: 59  -----YRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVV 113

Query: 96  ----PGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIH 151
               PGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIH
Sbjct: 114 DEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIH 173

Query: 152 GRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPG 211
           GRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPG
Sbjct: 174 GRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPG 233

Query: 212 LFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILA 271
           LFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILA
Sbjct: 234 LFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILA 293

Query: 272 PAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPA 331
           PAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPA
Sbjct: 294 PAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPA 353

Query: 332 KMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW 389
           KMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
Sbjct: 354 KMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW 411


>gi|189011548 N-acylsphingosine amidohydrolase 1 isoform a
           preproprotein [Homo sapiens]
          Length = 395

 Score =  693 bits (1788), Expect = 0.0
 Identities = 340/376 (90%), Positives = 340/376 (90%), Gaps = 36/376 (9%)

Query: 43  WTEDCRKSTYPPSGPTVFPAVIRYRGAVPWYTINLDLPPYKRWHELMLDKAPV------- 95
           WTEDCRKSTYPPSGPT       YRGAVPWYTINLDLPPYKRWHELMLDKAPV       
Sbjct: 27  WTEDCRKSTYPPSGPT-------YRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNS 79

Query: 96  ----------------------PGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYEL 133
                                 PGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYEL
Sbjct: 80  LKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYEL 139

Query: 134 FTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVF 193
           FTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVF
Sbjct: 140 FTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVF 199

Query: 194 KASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLEN 253
           KASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLEN
Sbjct: 200 KASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLEN 259

Query: 254 STSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQT 313
           STSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQT
Sbjct: 260 STSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQT 319

Query: 314 NYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKG 373
           NYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKG
Sbjct: 320 NYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKG 379

Query: 374 QFETYLRDCPDPCIGW 389
           QFETYLRDCPDPCIGW
Sbjct: 380 QFETYLRDCPDPCIGW 395


>gi|109148550 N-acylethanolamine acid amidase isoform 1 precursor
           [Homo sapiens]
          Length = 359

 Score =  183 bits (465), Expect = 2e-46
 Identities = 112/343 (32%), Positives = 175/343 (51%), Gaps = 44/343 (12%)

Query: 69  AVPWYTINLDLPPYKRW------HELMLDKAPVPGLLGN--------------------F 102
           A P + ++LD  P  RW      ++L L +A +  ++G+                     
Sbjct: 32  AAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFL 91

Query: 103 PGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLG 162
           P PF  E++G+    ++ L + +  N+ YE    CTSIVA+D +GH+ HGRN+D+     
Sbjct: 92  PQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYP---- 147

Query: 163 WNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFS 222
                        L+ LTV++ F +N +  F  ++F GYVG+ TG  P  F+++ +ER  
Sbjct: 148 ---------FGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDK 198

Query: 223 INGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQS 282
             G +       L ++ +  + +L R  L  S ++E A   L KT ++A  Y+I+GG   
Sbjct: 199 --GWWWENAIAALFRRHIP-VSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSP 255

Query: 283 GEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQEN 342
            EG VITR+R    D++ LD   G W+ V+TNYD WK     DDRRT A   LN T Q N
Sbjct: 256 REGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQAN 315

Query: 343 ISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDP 385
           +S E ++ +LS  PV N  T+YTT+  ++ G  + Y+    +P
Sbjct: 316 LSLEALFQILSVVPVYNNFTIYTTV--MSAGSPDKYMTRIRNP 356


>gi|109148548 N-acylethanolamine acid amidase isoform 2 precursor
           [Homo sapiens]
          Length = 323

 Score =  163 bits (412), Expect = 3e-40
 Identities = 100/307 (32%), Positives = 155/307 (50%), Gaps = 42/307 (13%)

Query: 69  AVPWYTINLDLPPYKRW------HELMLDKAPVPGLLGN--------------------F 102
           A P + ++LD  P  RW      ++L L +A +  ++G+                     
Sbjct: 32  AAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFL 91

Query: 103 PGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLG 162
           P PF  E++G+    ++ L + +  N+ YE    CTSIVA+D +GH+ HGRN+D+     
Sbjct: 92  PQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYP---- 147

Query: 163 WNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFS 222
                        L+ LTV++ F +N +  F  ++F GYVG+ TG  P  F+++ +ER  
Sbjct: 148 ---------FGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDK 198

Query: 223 INGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQS 282
             G +       L ++ +  + +L R  L  S ++E A   L KT ++A  Y+I+GG   
Sbjct: 199 --GWWWENAIAALFRRHIP-VSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSP 255

Query: 283 GEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQEN 342
            EG VITR+R    D++ LD   G W+ V+TNYD WK     DDRRT A   LN T Q N
Sbjct: 256 REGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQAN 315

Query: 343 ISFETMY 349
           +S E ++
Sbjct: 316 LSLEALF 322


>gi|4559408 colony stimulating factor 2 receptor, beta precursor
           [Homo sapiens]
          Length = 897

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 4/51 (7%)

Query: 12  RGSHRASYPSLSALFTEASILGFGSFAVKAQWTEDCRKSTYPPSGPTVFPA 62
           +G   + +P L  +F     +GFG   V     ED +    PPSGP   PA
Sbjct: 511 QGPWGSRFPELEGVFP----VGFGDSEVSPLTIEDPKHVCDPPSGPDTTPA 557


>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
          Length = 277

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 17/49 (34%), Positives = 30/49 (61%), Gaps = 1/49 (2%)

Query: 258 EEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQG 306
           EEAKNL+++  I A  +  LG   + + CVI++++ + L  Y +  K+G
Sbjct: 192 EEAKNLVSEA-IAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKG 239


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,287,646
Number of Sequences: 37866
Number of extensions: 686996
Number of successful extensions: 1215
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1202
Number of HSP's gapped (non-prelim): 7
length of query: 389
length of database: 18,247,518
effective HSP length: 104
effective length of query: 285
effective length of database: 14,309,454
effective search space: 4078194390
effective search space used: 4078194390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.